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Gene: ENO2 (enolase 2) Homo sapiens
Symbol: ENO2
Name: enolase 2
RGD ID: 733932
Description: Predicted to have enzyme binding activity and phosphopyruvate hydratase activity. Predicted to be involved in glycolytic process; negative regulation of neuron death; and regulation of vacuole fusion, non-autophagic. Localizes to cytosol and plasma membrane. Implicated in prostate cancer. Biomarker of several diseases, including breast carcinoma; hypertension; migraine without aura; neuroendocrine carcinoma; and urinary bladder cancer.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: 2-phospho-D-glycerate hydro-lyase; 2-phospho-D-glycerate hydrolyase; enolase 2 (gamma, neuronal); enolase 2, gamma; epididymis secretory protein Li 279; gamma-enolase; HEL-S-279; neural enolase; neuron specific gamma enolase; neuron-specific enolase; neuronal enriched enolase; neurone-specific enolase; NSE
Mus musculus (house mouse) : Eno2 (enolase 2, gamma neuronal)  MGI  Alliance
Rattus norvegicus (Norway rat) : Eno2 (enolase 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Eno2 (enolase 2)
Pan paniscus (bonobo/pygmy chimpanzee) : ENO2 (enolase 2)
Canis lupus familiaris (dog) : ENO2 (enolase 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Eno2 (enolase 2)
Sus scrofa (pig) : ENO2 (enolase 2)
Chlorocebus sabaeus (African green monkey) : ENO2 (enolase 2)
Heterocephalus glaber (naked mole-rat) : Eno2 (enolase 2)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 Ensembl126,913,745 - 6,923,698 (+)EnsemblGRCh38hg38GRCh38
GRCh38126,914,580 - 6,923,697 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37127,023,614 - 7,032,860 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36126,893,875 - 6,903,120 (+)NCBINCBI36hg18NCBI36
Build 34126,893,874 - 6,903,120NCBI
Celera128,642,227 - 8,651,475 (+)NCBI
Cytogenetic Map12p13.31NCBI
HuRef126,879,463 - 6,888,873 (+)NCBIHuRef
CHM1_1127,022,496 - 7,031,732 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on ENO2
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 733932
Created: 2004-01-12
Species: Homo sapiens
Last Modified: 2020-09-16
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.