RGD Reference Report - Large cell and small cell neuroendocrine bladder carcinoma: immunohistochemical and outcome study in a single institution. - Rat Genome Database

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Large cell and small cell neuroendocrine bladder carcinoma: immunohistochemical and outcome study in a single institution.

Authors: Alijo Serrano, F  Sanchez-Mora, N  Angel Arranz, J  Hernandez, C  Alvarez-Fernandez, E 
Citation: Alijo Serrano F, etal., Am J Clin Pathol. 2007 Nov;128(5):733-9.
RGD ID: 2293738
Pubmed: PMID:17951193   (View Abstract at PubMed)
DOI: DOI:10.1309/HTREM6QYQDYGNWYA   (Journal Full-text)

We studied 44 cases of small cell bladder carcinoma (SCBC) and 2 cases of large cell neuroendocrine bladder carcinoma (LCNBC) to determine the immunohistochemical profile and biologic behavior. Thyroid transcription factor (TTF)-1, cytokeratin (CK)20, chromogranin A (CgA), synaptophysin, neuron-specific enolase (NSE), and Leu-7 studies were performed. TTF-1+ cases were stained for surfactant protein A (SP-A). The immunohistochemical profile for 44 SCBC cases was as follows: TTF-1+, 11 (25%); CK20+, 3 (7%); CgA+, 13 (30%); synaptophysin+, 22 (50%); NSE+, 35 (80%); and Leu-7+, 30 (68%), and for 2 LCNBC cases was as follows: TTF-1+, 2 (100%); CgA+, (50%); synaptophysin+, 1 (50%); NSE+, 2 (100%); and Leu- 7+, 2 (100%). All cases with TTF-1 expression were negative for SP-A, except 1 case. This case was a mixed SCBC with TTF-1 expression in the urothelial component, which also expressed SP-A. Immunohistochemical markers were not associated with survival. The prognosis of SCBC is relatively better than its pulmonary counterpart. LCNBC seems to be a rarely recognized entity. TTF-1 expression is not limited to small cell lung carcinoma.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
ENO2Humanurinary bladder cancer  IEP  RGD 
Eno2Raturinary bladder cancer  ISOENO2 (Homo sapiens) RGD 
Eno2Mouseurinary bladder cancer  ISOENO2 (Homo sapiens) RGD 

Objects Annotated

Genes (Rattus norvegicus)
Eno2  (enolase 2)

Genes (Mus musculus)
Eno2  (enolase 2, gamma neuronal)

Genes (Homo sapiens)
ENO2  (enolase 2)


Additional Information