RGD Reference Report - Combined large cell neuroendocrine and endometrioid carcinoma of the endometrium. - Rat Genome Database

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Combined large cell neuroendocrine and endometrioid carcinoma of the endometrium.

Authors: Mulvany, NJ  Allen, DG 
Citation: Mulvany NJ and Allen DG, Int J Gynecol Pathol. 2008 Jan;27(1):49-57.
RGD ID: 2293737
Pubmed: (View Article at PubMed) PMID:18156975
DOI: Full-text: DOI:10.1097/pgp.0b013e31806219c5

We present the surgical and pathological findings and follow-up of 5 women diagnosed with combined endometrioid and high-grade neuroendocrine carcinoma of large cell type (LCNEC) arising in the endometrium. The mean age of the women was 75 years (range, 50-88 years). Of the 5 tumors, 4 formed polypoid endometrial masses associated with extensive lymphovascular involvement of the myometrium by neoplastic cells. A single endometrial tumor was formed by LCNEC alone, and 4 tumors were composite with varying proportions formed by endometrioid (4/5) and small cell neuroendocrine carcinoma (1/5). In all 5 LCNEC tumor components, an insular growth pattern was noted, whereas a diffuse (solid) pattern was found in 4 tumors, a trabecular in 2, and rosettes/pseudorosettes in another 2. In all 5 tumors, the LCNEC tumor components were labeled with neuron-specific enolase (NSE). Four tumors were reactive for chromogranin A, CAM 5.2, and p53. Three tumors were labeled for AE1/AE3, CD56 (NCAM), p16, and cytokeratin 7. Synaptophysin was reactive in 2 tumors, and CD117 was found in only a single tumor. Of the 3 endometrioid tumor components examined, all were reactive for NSE. Two tumors were reactive for p16 and p53, 1 for CD56, but none for synaptophysin orchromogranin A. We conclude that LCNEC of the endometrium is a distinct clinicopathological entity with a poor prognosis irrespective of stage. The gross and histomorphological features are often suggestive, but confirmation requires immunoperoxidases, including NSE, synaptophysin, chromogranin A, p16, and p53. Combined endometrioid and high-grade LCNEC possess more characteristics of a type II than a type I endometrial carcinoma.

Annotation

Disease Annotations    

Objects Annotated

Genes (Rattus norvegicus)
Eno2  (enolase 2)

Genes (Mus musculus)
Eno2  (enolase 2, gamma neuronal)

Genes (Homo sapiens)
ENO2  (enolase 2)


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