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Gene: TPX2 (TPX2 microtubule nucleation factor) Homo sapiens
Symbol: TPX2
Name: TPX2 microtubule nucleation factor
Description: Exhibits importin-alpha family protein binding activity and protein kinase binding activity. Involved in activation of protein kinase activity; microtubule cytoskeleton organization; and negative regulation of microtubule depolymerization. Localizes to intercellular bridge; mitotic spindle; and nucleoplasm. Colocalizes with spindle pole; INTERACTS WITH 17beta-estradiol; 17beta-hydroxy-17-methylestra-4,9,11-trien-3-one; 2,3-dimethoxynaphthalene-1,4-dione.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: C20orf1; C20orf2; differentially expressed in cancerous and non-cancerous lung cells 2; differentially expressed in lung cells; DIL-2; DIL2; FLS353; GD:C20orf1; HCA519; HCTP4; hepatocellular carcinoma-associated antigen 519; hepatocellular carcinoma-associated antigen 90; p100; preferentially expressed in colorectal cancer; REPP86; restricted expression proliferation associated protein 100; restricted expression proliferation-associated protein 100; targeting protein for Xklp2; TPX2, microtubule nucleation factor; TPX2, microtubule-associated; TPX2, microtubule-associated protein homolog; tpx2, microtubule-associated protein homolog (xenopus laevis); TPX2, microtubule-associated, homolog
Mus musculus (house mouse) : Tpx2 (TPX2, microtubule-associated)  MGI  Alliance
Rattus norvegicus (Norway rat) : Tpx2 (TPX2, microtubule nucleation factor)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Tpx2 (TPX2 microtubule nucleation factor)
Pan paniscus (bonobo/pygmy chimpanzee) : TPX2 (TPX2 microtubule nucleation factor)
Canis lupus familiaris (dog) : TPX2 (TPX2 microtubule nucleation factor)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Tpx2 (TPX2 microtubule nucleation factor)
Sus scrofa (pig) : TPX2 (TPX2 microtubule nucleation factor)
Chlorocebus sabaeus (African green monkey) : TPX2 (TPX2 microtubule nucleation factor)
Heterocephalus glaber (naked mole-rat) : Tpx2 (TPX2 microtubule nucleation factor)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 Ensembl2031,739,271 - 31,801,805 (+)EnsemblGRCh38hg38GRCh38
GRCh382031,739,248 - 31,801,802 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh372030,326,904 - 30,389,605 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362029,790,565 - 29,853,264 (+)NCBINCBI36hg18NCBI36
Build 342029,790,564 - 29,853,264NCBI
Celera2027,083,256 - 27,145,950 (+)NCBI
Cytogenetic Map20q11.21NCBI
HuRef2027,115,888 - 27,178,524 (+)NCBIHuRef
CHM1_12030,230,786 - 30,293,470 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on TPX2
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1323589
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2020-07-28
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.