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Gene: USP5 (ubiquitin specific peptidase 5) Homo sapiens
Symbol: USP5
Name: ubiquitin specific peptidase 5
RGD ID: 1318206
Description: Exhibits thiol-dependent ubiquitin-specific protease activity and ubiquitin binding activity. Involved in positive regulation of proteasomal ubiquitin-dependent protein catabolic process and protein K48-linked deubiquitination. Predicted to localize to cytosol and nucleus.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: deubiquitinating enzyme 5; isopeptidase T; ISOT; testicular tissue protein Li 218; ubiquitin carboxyl-terminal hydrolase 5; ubiquitin isopeptidase T; ubiquitin specific peptidase 5 (isopeptidase T); ubiquitin specific protease 5 (isopeptidase T); ubiquitin thioesterase 5; ubiquitin thiolesterase 5; ubiquitin-specific protease-5 (ubiquitin isopeptidase T); ubiquitin-specific-processing protease 5
Mus musculus (house mouse) : Usp5 (ubiquitin specific peptidase 5 (isopeptidase T))  MGI  Alliance
Rattus norvegicus (Norway rat) : Usp5 (ubiquitin specific peptidase 5)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Usp5 (ubiquitin specific peptidase 5)
Pan paniscus (bonobo/pygmy chimpanzee) : USP5 (ubiquitin specific peptidase 5)
Canis lupus familiaris (dog) : USP5 (ubiquitin specific peptidase 5)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Usp5 (ubiquitin specific peptidase 5)
Sus scrofa (pig) : USP5 (ubiquitin specific peptidase 5)
Chlorocebus sabaeus (African green monkey) : USP5 (ubiquitin specific peptidase 5)
Heterocephalus glaber (naked mole-rat) : Usp5 (ubiquitin specific peptidase 5)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 Ensembl126,852,128 - 6,866,632 (+)EnsemblGRCh38hg38GRCh38
GRCh38126,852,150 - 6,866,632 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37126,961,285 - 6,975,796 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36126,831,546 - 6,846,057 (+)NCBINCBI36hg18NCBI36
Build 34126,831,583 - 6,846,054NCBI
Celera128,578,571 - 8,593,082 (+)NCBI
Cytogenetic Map12p13.31NCBI
HuRef126,815,013 - 6,829,524 (+)NCBIHuRef
CHM1_1126,960,283 - 6,974,794 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on USP5
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1318206
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2020-09-16
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.