USP5 (ubiquitin specific peptidase 5) - Rat Genome Database

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Gene: USP5 (ubiquitin specific peptidase 5) Homo sapiens
Analyze
Symbol: USP5
Name: ubiquitin specific peptidase 5
RGD ID: 1318206
HGNC Page HGNC:12628
Description: Enables cysteine-type deubiquitinase activity and ubiquitin binding activity. Involved in negative regulation of ubiquitin-dependent protein catabolic process; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; and protein K48-linked deubiquitination. Predicted to be located in lysosome. Predicted to be active in cytosol and nucleus.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: deubiquitinating enzyme 5; isopeptidase T; ISOT; testicular tissue protein Li 218; ubiquitin carboxyl-terminal hydrolase 5; ubiquitin isopeptidase T; ubiquitin specific peptidase 5 (isopeptidase T); ubiquitin specific protease 5 (isopeptidase T); ubiquitin thioesterase 5; ubiquitin thiolesterase 5; ubiquitin-specific protease-5 (ubiquitin isopeptidase T); ubiquitin-specific-processing protease 5
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38126,852,150 - 6,866,632 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl126,852,148 - 6,866,632 (+)EnsemblGRCh38hg38GRCh38
GRCh37126,961,314 - 6,975,796 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36126,831,546 - 6,846,057 (+)NCBINCBI36Build 36hg18NCBI36
Build 34126,831,583 - 6,846,054NCBI
Celera128,578,571 - 8,593,082 (+)NCBICelera
Cytogenetic Map12p13.31NCBI
HuRef126,815,013 - 6,829,524 (+)NCBIHuRef
CHM1_1126,960,283 - 6,974,794 (+)NCBICHM1_1
T2T-CHM13v2.0126,861,449 - 6,875,929 (+)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
USP5Humandevelopmental and epileptic encephalopathy 21  IAGP (Homo sapiens)8554872ClinVar Annotator: match by term: Developmental and epileptic encephalopathy and 21ClinVarPMID:28492532
USP5HumanHyperphosphatemic Familial Tumoral Calcinosis 1  IAGP (Homo sapiens)8554872ClinVar Annotator: match by term: Tumoral calcinosis more ...ClinVarPMID:25378588 and PMID:29389098
USP5HumanKlippel-Feil syndrome 3  IAGP (Homo sapiens)8554872ClinVar Annotator: match by term: Klippel-Feil syndrome 3 and autosomal dominantClinVarPMID:28492532
USP5Humanlymphoproliferative syndrome 2  IAGP (Homo sapiens)8554872ClinVar Annotator: match by term: Lymphoproliferative syndrome 2ClinVarPMID:28492532
USP5Humanperoxisome biogenesis disorder 2B  IAGP (Homo sapiens)8554872ClinVar Annotator: match by term: Peroxisome biogenesis disorder 2BClinVarPMID:28492532
USP5HumanTemtamy syndrome  IAGP (Homo sapiens) more ...8554872ClinVar Annotator: match by term: Temtamy syndromeClinVarPMID:28492532
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
USP5HumanChemical and Drug Induced Liver Injury  EXP 11554173CTD Direct Evidence: marker/mechanismCTDPMID:25231249

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Object Symbol
Species
Term
Qualifier
Evidence
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Reference
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Source
Original Reference(s)
USP5Human(-)-epigallocatechin 3-gallate decreases expressionEXP 6480464epigallocatechin gallate results in decreased expression of USP5 mRNACTDPMID:18851785
USP5Human1,2-dimethylhydrazine increases expressionISOUsp5 (Mus musculus)64804641 and 2-Dimethylhydrazine results in increased expression of USP5 mRNACTDPMID:22206623
USP5Human1,2-dimethylhydrazine multiple interactionsISOUsp5 (Mus musculus)6480464[1 and 2-Dimethylhydrazine co-treated with Folic Acid] results in increased expression of USP5 mRNACTDPMID:22206623
USP5Human17beta-estradiol increases expressionISOUsp5 (Mus musculus)6480464Estradiol results in increased expression of USP5 mRNACTDPMID:39298647
USP5Human17beta-hydroxy-17-methylestra-4,9,11-trien-3-one affects localizationEXP 6480464Metribolone affects the localization of USP5 proteinCTDPMID:17440980
USP5Human2,2',4,4'-Tetrabromodiphenyl ether decreases expressionEXP 64804642 more ...CTDPMID:31675489
USP5Human2,3,7,8-tetrachlorodibenzodioxine decreases expressionISOUsp5 (Rattus norvegicus)6480464Tetrachlorodibenzodioxin results in decreased expression of USP5 mRNACTDPMID:33387578
USP5Human2,3,7,8-Tetrachlorodibenzofuran decreases expressionISOUsp5 (Rattus norvegicus)64804642 more ...CTDPMID:32109520
USP5Human2,4-dinitrotoluene affects expressionISOUsp5 (Rattus norvegicus)64804642 and 4-dinitrotoluene affects the expression of USP5 mRNACTDPMID:21346803
USP5Human2,6-dimethoxyphenol multiple interactionsEXP 6480464[pyrogallol 1 more ...CTDPMID:38598786
USP5Human2-bromohexadecanoic acid multiple interactionsEXP 64804642-bromopalmitate inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased palmitoylation of USP5 protein]CTDPMID:38195004
USP5Human2-hydroxypropanoic acid decreases expressionEXP 6480464Lactic Acid results in decreased expression of USP5 mRNACTDPMID:30851411
USP5Human3,4-methylenedioxymethamphetamine increases expressionISOUsp5 (Mus musculus)6480464N-Methyl-3 and 4-methylenedioxyamphetamine results in increased expression of USP5 mRNACTDPMID:20188158
USP5Human3-cyanoalanine multiple interactionsISOUsp5 (Mus musculus)64804643-cyanoalanine inhibits the reaction [[N more ...CTDPMID:29129814
USP5Human4,4'-sulfonyldiphenol increases expressionISOUsp5 (Mus musculus)6480464bisphenol S results in increased expression of USP5 mRNACTDPMID:39298647
USP5Human4,4'-sulfonyldiphenol multiple interactionsISOUsp5 (Rattus norvegicus)6480464[bisphenol A co-treated with bisphenol F co-treated with bisphenol S] results in increased expression of USP5 mRNACTDPMID:36041667
USP5Human4,4'-sulfonyldiphenol decreases methylationISOUsp5 (Mus musculus)6480464bisphenol S results in decreased methylation of USP5 promoterCTDPMID:33297965
USP5Humanacetamide decreases expressionISOUsp5 (Rattus norvegicus)6480464acetamide results in decreased expression of USP5 mRNACTDPMID:31881176
USP5Humanacrylamide increases expressionISOUsp5 (Rattus norvegicus)6480464Acrylamide results in increased expression of USP5 mRNACTDPMID:28959563
USP5Humanactinomycin D multiple interactionsEXP 6480464[Dactinomycin co-treated with nutlin 3] results in increased secretion of USP5 proteinCTDPMID:38460933

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Biological Process
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Object Symbol
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Reference
Notes
Source
Original Reference(s)
USP5Humannegative regulation of proteasomal ubiquitin-dependent protein catabolic process involved_inIDA 150520179 PMID:37534934UniProtPMID:37534934
USP5Humannegative regulation of T cell mediated immune response to tumor cell involved_inIDA 150520179 PMID:37208329UniProtPMID:37208329
USP5Humannegative regulation of ubiquitin-dependent protein catabolic process involved_inIDA 150520179 PMID:24424410ParkinsonsUK-UCLPMID:24424410
USP5Humanpositive regulation of proteasomal ubiquitin-dependent protein catabolic process involved_inIMP 150520179 PMID:19098288UniProtPMID:19098288
USP5Humanprotein deubiquitination involved_inIEAInterPro:IPR001394 and InterPro:IPR016652150520179 InterProGO_REF:0000002
USP5Humanprotein deubiquitination involved_inIEAARBA:ARBA00027879150520179 UniProtGO_REF:0000117
USP5Humanprotein deubiquitination involved_inTAS 150520179 ReactomeReactome:R-HSA-5688426
USP5Humanprotein K48-linked deubiquitination involved_inIMP 150520179 PMID:19098288UniProtPMID:19098288
USP5Humanprotein ubiquitination involved_inTAS 150520179 ReactomeReactome:R-HSA-8866652
USP5Humanproteolysis involved_inIEAUniProtKB-KW:KW-0645150520179 UniProtGO_REF:0000043
USP5Humanregulation of protein stability involved_inIBAFB:FBgn0016756 more ...150520179 GO_CentralGO_REF:0000033
USP5Humanregulation protein catabolic process at presynapse involved_inIEAUniProtKB:P56399 and ensembl:ENSMUSP00000041299150520179 EnsemblGO_REF:0000107
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Cellular Component

  
Object Symbol
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Term
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Reference
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Original Reference(s)
USP5Humancytoplasm is_active_inIDA 150520179 PMID:37208329UniProtPMID:37208329
USP5Humancytosol located_inTAS 150520179 ReactomeReactome:R-HSA-5690152 more ...
USP5Humancytosol is_active_inIBAFB:FBgn0016756 more ...150520179 GO_CentralGO_REF:0000033
USP5Humanlysosome located_inTAS 150520179 PMID:9827704PINCPMID:9827704
USP5Humannucleus is_active_inIBAFB:FBgn0016756 more ...150520179 GO_CentralGO_REF:0000033
USP5Humanpresynapse located_inIEAGO:0140251150520179 GOCGO_REF:0000108

Molecular Function
1 to 20 of 23 rows

  
Object Symbol
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Original Reference(s)
USP5Humancysteine-type deubiquitinase activity enablesIDA 150520179 PMID:24424410ParkinsonsUK-UCLPMID:24424410
USP5Humancysteine-type deubiquitinase activity enablesIEAARBA:ARBA00026880150520179 UniProtGO_REF:0000117
USP5Humancysteine-type deubiquitinase activity enablesIBAFB:FBgn0005632 more ...150520179 GO_CentralGO_REF:0000033
USP5Humancysteine-type deubiquitinase activity enablesIEAUniRule:UR000859761 and UniRule:UR000880756150520179 UniProtGO_REF:0000104
USP5Humancysteine-type deubiquitinase activity enablesEXP 150520179 PMID:26235645ReactomePMID:26235645
USP5Humancysteine-type deubiquitinase activity enablesTAS 150520179 ReactomeReactome:R-HSA-5690152
USP5Humancysteine-type deubiquitinase activity enablesIEAInterPro:IPR001394 more ...150520179 InterProGO_REF:0000002
USP5Humancysteine-type deubiquitinase activity enablesIEAEC:3.4.19.12150520179 UniProtGO_REF:0000003
USP5Humancysteine-type endopeptidase activity enablesTAS 150520179 PMID:7578059PINCPMID:7578059
USP5Humancysteine-type peptidase activity enablesIEAUniProtKB-KW:KW-0788150520179 UniProtGO_REF:0000043
USP5Humandeubiquitinase activity enablesIDA 150520179 PMID:26917723 and PMID:37534934FlyBasePMID:26917723 and PMID:37534934
USP5Humanhydrolase activity enablesIEAUniProtKB-KW:KW-0378150520179 UniProtGO_REF:0000043
USP5Humanmetal ion binding enablesIEAUniProtKB-KW:KW-0479150520179 UniProtGO_REF:0000043
USP5Humanpeptidase activity enablesIEAUniProtKB-KW:KW-0645150520179 UniProtGO_REF:0000043
USP5Humanprotein binding enablesIPIUniProtKB:O14773 and UniProtKB:P0CG47150520179 PMID:32814053IntActPMID:32814053
USP5Humanprotein binding enablesIPIUniProtKB:Q8N0X7 more ...150520179 PMID:32296183IntActPMID:32296183
USP5Humanprotein binding enablesIPIUniProtKB:O75528150520179 PMID:16189514IntActPMID:16189514
USP5Humanprotein binding enablesIPIUniProtKB:Q15038 and UniProtKB:Q8WW34150520179 PMID:25416956IntActPMID:25416956
USP5Humanprotein binding enablesIPIUniProtKB:P54727150520179 PMID:16712842IntActPMID:16712842
USP5Humanubiquitin binding enablesIDA 150520179 PMID:24424410ParkinsonsUK-UCLPMID:24424410
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#
Reference Title
Reference Citation
1. GOAs Human GO annotations GOA_HUMAN data from the GO Consortium
2. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
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PMID:7498549   PMID:7578059   PMID:7851534   PMID:8723724   PMID:8841133   PMID:9074930   PMID:9827704   PMID:11337467   PMID:11771738   PMID:12427038   PMID:12435595   PMID:12477932  
PMID:12838346   PMID:14718574   PMID:15096053   PMID:15146197   PMID:15231748   PMID:15489334   PMID:16007098   PMID:16189514   PMID:16564012   PMID:16712842   PMID:16964243   PMID:17148452  
PMID:17550899   PMID:17692280   PMID:17980597   PMID:18029348   PMID:18482987   PMID:18601651   PMID:19013454   PMID:19098288   PMID:19156909   PMID:19285159   PMID:19373254   PMID:19615732  
PMID:20622874   PMID:20804422   PMID:21832049   PMID:21873635   PMID:21976412   PMID:22079093   PMID:22118674   PMID:22216260   PMID:22283393   PMID:22428841   PMID:22451720   PMID:22586326  
PMID:22626734   PMID:22658674   PMID:22863883   PMID:22878415   PMID:22939629   PMID:23105109   PMID:23287719   PMID:23314748   PMID:23375434   PMID:23563141   PMID:23720098   PMID:23751493  
PMID:24424410   PMID:24454762   PMID:24681967   PMID:25207809   PMID:25416956   PMID:25641936   PMID:25889575   PMID:25921289   PMID:25970461   PMID:26142280   PMID:26235645   PMID:26344197  
PMID:26414014   PMID:26508657   PMID:26638075   PMID:26777405   PMID:26876099   PMID:26912724   PMID:26917723   PMID:27066941   PMID:27130589   PMID:27133717   PMID:27613037   PMID:27848959  
PMID:28190767   PMID:28380382   PMID:28515276   PMID:28675297   PMID:28807830   PMID:28846114   PMID:28933784   PMID:29117863   PMID:29467282   PMID:29567855   PMID:29576527   PMID:30110629  
PMID:30196744   PMID:30575818   PMID:30809294   PMID:30833792   PMID:30884312   PMID:31048545   PMID:31067491   PMID:31073040   PMID:31091453   PMID:31197245   PMID:31281542   PMID:31300459  
PMID:31343991   PMID:31371702   PMID:31410188   PMID:31455361   PMID:31541095   PMID:31586073   PMID:31663737   PMID:31699778   PMID:31727867   PMID:31732153   PMID:31839598   PMID:31871319  
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USP5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38126,852,150 - 6,866,632 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl126,852,148 - 6,866,632 (+)EnsemblGRCh38hg38GRCh38
GRCh37126,961,314 - 6,975,796 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36126,831,546 - 6,846,057 (+)NCBINCBI36Build 36hg18NCBI36
Build 34126,831,583 - 6,846,054NCBI
Celera128,578,571 - 8,593,082 (+)NCBICelera
Cytogenetic Map12p13.31NCBI
HuRef126,815,013 - 6,829,524 (+)NCBIHuRef
CHM1_1126,960,283 - 6,974,794 (+)NCBICHM1_1
T2T-CHM13v2.0126,861,449 - 6,875,929 (+)NCBIT2T-CHM13v2.0
Usp5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm396124,791,982 - 124,806,404 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl6124,791,982 - 124,806,447 (-)EnsemblGRCm39 Ensembl
GRCm386124,815,019 - 124,829,484 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl6124,815,019 - 124,829,484 (-)EnsemblGRCm38mm10GRCm38
MGSCv376124,765,037 - 124,779,465 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv366124,780,638 - 124,795,066 (-)NCBIMGSCv36mm8
Celera6126,491,148 - 126,505,576 (-)NCBICelera
Cytogenetic Map6F2NCBI
cM Map659.17NCBI
Usp5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84159,305,927 - 159,321,345 (-)NCBIGRCr8
mRatBN7.24157,619,663 - 157,634,681 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4157,619,643 - 157,634,711 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4163,847,808 - 163,862,942 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04159,630,718 - 159,645,852 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04158,266,340 - 158,281,358 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.04157,332,735 - 157,347,803 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4157,332,740 - 157,347,803 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04224,350,331 - 224,365,479 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44160,937,706 - 160,952,769 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera4146,357,626 - 146,372,628 (-)NCBICelera
Cytogenetic Map4q42NCBI
Usp5
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554134,451,622 - 4,466,832 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554134,451,530 - 4,466,832 (+)NCBIChiLan1.0ChiLan1.0
USP5
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21012,414,488 - 12,429,794 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11212,411,246 - 12,426,552 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0126,983,941 - 6,998,469 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1126,895,416 - 6,909,936 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl126,895,416 - 6,909,936 (+)Ensemblpanpan1.1panPan2
USP5
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12738,158,850 - 38,172,689 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2738,158,834 - 38,172,071 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha278,444,116 - 8,457,897 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02738,511,741 - 38,525,542 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2738,511,746 - 38,524,959 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12738,385,805 - 38,399,013 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02738,426,829 - 38,440,619 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0277,922,848 - 7,936,630 (+)NCBIUU_Cfam_GSD_1.0
Usp5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404945102,284,676 - 102,298,641 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936709952,182 - 966,498 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936709952,225 - 966,429 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
USP5
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl563,843,745 - 63,858,716 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1563,843,742 - 63,858,835 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2566,279,250 - 66,294,259 (-)NCBISscrofa10.2Sscrofa10.2susScr3
USP5
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1116,885,401 - 6,899,983 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl116,885,311 - 6,898,442 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660631,323,576 - 1,338,147 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Usp5
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248603,519,113 - 3,532,687 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248603,519,106 - 3,532,690 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in USP5
52 total Variants

Predicted Target Of
Summary Value
Count of predictions:2573
Count of miRNA genes:777
Interacting mature miRNAs:947
Transcripts:ENST00000229268, ENST00000389231, ENST00000535080, ENST00000537267, ENST00000541969, ENST00000542087, ENST00000542371
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
597241387GWAS1337461_Hcystatin C measurement QTL GWAS1337461 (human)4e-122cystatin C measurementblood cystatin C level (CMO:0002777)1268595776859578Human
597139722GWAS1235796_Hgamma-enolase measurement QTL GWAS1235796 (human)3e-11gamma-enolase measurement1268626416862642Human
597121656GWAS1217730_Hblood protein measurement QTL GWAS1217730 (human)5e-17blood protein amount (VT:0005416)blood protein measurement (CMO:0000028)1268560306856031Human

RH48309  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37126,967,724 - 6,967,853UniSTSGRCh37
Build 36126,837,985 - 6,838,114RGDNCBI36
Celera128,585,010 - 8,585,139RGD
Cytogenetic Map12p13UniSTS
HuRef126,821,452 - 6,821,581UniSTS
GeneMap99-GB4 RH Map1243.35UniSTS
NCBI RH Map1294.1UniSTS
RH78311  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37126,975,611 - 6,975,762UniSTSGRCh37
Build 36126,845,872 - 6,846,023RGDNCBI36
Celera128,592,897 - 8,593,048RGD
Cytogenetic Map12p13UniSTS
HuRef126,829,339 - 6,829,490UniSTS
GeneMap99-GB4 RH Map1243.35UniSTS
NCBI RH Map1294.1UniSTS
SHGC-32489  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37126,975,636 - 6,975,783UniSTSGRCh37
Build 36126,845,897 - 6,846,044RGDNCBI36
Celera128,592,922 - 8,593,069RGD
Cytogenetic Map12p13UniSTS
HuRef126,829,364 - 6,829,511UniSTS
GeneMap99-GB4 RH Map1243.69UniSTS
Whitehead-RH Map1275.3UniSTS
GeneMap99-G3 RH Map12439.0UniSTS
MARC_7181-7182:996687603:1  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37126,973,227 - 6,973,962UniSTSGRCh37
Build 36126,843,488 - 6,844,223RGDNCBI36
Celera128,590,513 - 8,591,248RGD
HuRef126,826,955 - 6,827,690UniSTS
USP5__5052  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37126,975,154 - 6,975,797UniSTSGRCh37
Build 36126,845,415 - 6,846,058RGDNCBI36
Celera128,592,440 - 8,593,083RGD
HuRef126,828,882 - 6,829,525UniSTS




adipose tissue
alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
entire extraembryonic component
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
pharyngeal arch
renal system
reproductive system
respiratory system
sensory system
visual system
1204 2439 2788 2253 4974 1726 2351 6 624 1951 465 2270 7306 6472 53 3734 1 852 1744 1617 175 1


1 to 29 of 29 rows
RefSeq Transcripts NM_001098536 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001382588 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001382589 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001382590 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001382591 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_003481 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_168449 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_168450 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_168451 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_168452 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_168454 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_168455 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_168456 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_168457 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_168458 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AI289395 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK308021 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AU099996 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC004889 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC005139 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471116 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CN276110 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068266 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM005531 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KC877513 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U35116 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U47924 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U47927 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X91349 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
1 to 29 of 29 rows

Ensembl Acc Id: ENST00000229268   ⟹   ENSP00000229268
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl126,852,150 - 6,866,632 (+)Ensembl
Ensembl Acc Id: ENST00000389231   ⟹   ENSP00000373883
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl126,852,148 - 6,866,620 (+)Ensembl
Ensembl Acc Id: ENST00000535080
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl126,856,856 - 6,858,826 (+)Ensembl
Ensembl Acc Id: ENST00000537267
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl126,857,401 - 6,866,632 (+)Ensembl
Ensembl Acc Id: ENST00000541969
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl126,860,464 - 6,863,916 (+)Ensembl
Ensembl Acc Id: ENST00000542087   ⟹   ENSP00000444668
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl126,852,153 - 6,861,090 (+)Ensembl
Ensembl Acc Id: ENST00000542371
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl126,863,336 - 6,866,104 (+)Ensembl
RefSeq Acc Id: NM_001098536   ⟹   NP_001092006
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38126,852,150 - 6,866,632 (+)NCBI
GRCh37126,961,285 - 6,975,796 (+)ENTREZGENE
Build 36126,831,546 - 6,846,057 (+)NCBI Archive
HuRef126,815,013 - 6,829,524 (+)ENTREZGENE
CHM1_1126,960,283 - 6,974,794 (+)NCBI
T2T-CHM13v2.0126,861,449 - 6,875,929 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001382588   ⟹   NP_001369517
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38126,852,150 - 6,866,632 (+)NCBI
T2T-CHM13v2.0126,861,449 - 6,875,929 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001382589   ⟹   NP_001369518
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38126,852,150 - 6,866,632 (+)NCBI
T2T-CHM13v2.0126,861,449 - 6,875,929 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001382590   ⟹   NP_001369519
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38126,852,150 - 6,866,632 (+)NCBI
T2T-CHM13v2.0126,861,449 - 6,875,929 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001382591   ⟹   NP_001369520
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38126,852,150 - 6,866,632 (+)NCBI
T2T-CHM13v2.0126,861,449 - 6,875,929 (+)NCBI
Sequence:
RefSeq Acc Id: NM_003481   ⟹   NP_003472
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38126,852,150 - 6,866,632 (+)NCBI
GRCh37126,961,285 - 6,975,796 (+)ENTREZGENE
Build 36126,831,552 - 6,846,057 (+)NCBI Archive
HuRef126,815,013 - 6,829,524 (+)ENTREZGENE
CHM1_1126,960,289 - 6,974,794 (+)NCBI
T2T-CHM13v2.0126,861,449 - 6,875,929 (+)NCBI
Sequence:
RefSeq Acc Id: NR_168449
RefSeq Status: VALIDATED
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38126,852,150 - 6,866,632 (+)NCBI
T2T-CHM13v2.0126,861,449 - 6,875,929 (+)NCBI
Sequence:
RefSeq Acc Id: NR_168450
RefSeq Status: VALIDATED
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38126,852,150 - 6,866,632 (+)NCBI
T2T-CHM13v2.0126,861,449 - 6,875,929 (+)NCBI
Sequence:
RefSeq Acc Id: NR_168451
RefSeq Status: VALIDATED
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38126,852,150 - 6,866,632 (+)NCBI
T2T-CHM13v2.0126,861,449 - 6,875,929 (+)NCBI
Sequence:
RefSeq Acc Id: NR_168452
RefSeq Status: VALIDATED
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38126,852,150 - 6,866,632 (+)NCBI
T2T-CHM13v2.0126,861,449 - 6,875,929 (+)NCBI
Sequence:
RefSeq Acc Id: NR_168454
RefSeq Status: VALIDATED
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38126,852,150 - 6,866,632 (+)NCBI
T2T-CHM13v2.0126,861,449 - 6,875,929 (+)NCBI
Sequence:
RefSeq Acc Id: NR_168455
RefSeq Status: VALIDATED
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38126,852,150 - 6,866,632 (+)NCBI
T2T-CHM13v2.0126,861,449 - 6,875,929 (+)NCBI
Sequence:
RefSeq Acc Id: NR_168456
RefSeq Status: VALIDATED
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38126,852,150 - 6,866,632 (+)NCBI
T2T-CHM13v2.0126,861,449 - 6,875,929 (+)NCBI
Sequence:
RefSeq Acc Id: NR_168457
RefSeq Status: VALIDATED
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38126,852,150 - 6,866,632 (+)NCBI
T2T-CHM13v2.0126,861,449 - 6,875,929 (+)NCBI
Sequence:
RefSeq Acc Id: NR_168458
RefSeq Status: VALIDATED
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38126,852,150 - 6,866,632 (+)NCBI
T2T-CHM13v2.0126,861,449 - 6,875,929 (+)NCBI
Sequence:
RefSeq Acc Id: NP_001092006   ⟸   NM_001098536
- Peptide Label: isoform 1
- UniProtKB: D3DUS8 (UniProtKB/Swiss-Prot),   D3DUS7 (UniProtKB/Swiss-Prot),   Q96J22 (UniProtKB/Swiss-Prot),   P45974 (UniProtKB/Swiss-Prot),   A0A140VJZ1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_003472   ⟸   NM_003481
- Peptide Label: isoform 2
- UniProtKB: P45974 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001369519   ⟸   NM_001382590
- Peptide Label: isoform 5
RefSeq Acc Id: NP_001369520   ⟸   NM_001382591
- Peptide Label: isoform 6
RefSeq Acc Id: NP_001369517   ⟸   NM_001382588
- Peptide Label: isoform 3
Name Modeler Protein Id AA Range Protein Structure
AF-P45974-F1-model_v2 AlphaFold P45974 1-858 view protein structure

RGD ID:6790653
Promoter ID:HG_KWN:14855
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   CD4+TCell_2Hour,   HeLa_S3,   Jurkat,   K562,   Lymphoblastoid,   NB4
Transcripts:NM_001098536,   UC001QRH.2
Position:
Human AssemblyChrPosition (strand)Source
Build 36126,830,841 - 6,831,787 (+)MPROMDB
RGD ID:6853036
Promoter ID:EP74339
Type:initiation region
Name:HS_USP5
Description:Ubiquitin specific protease 5 (isopeptidase T).
SO ACC ID:SO:0000170
Source:EPD (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Mammalian gene collection (MGC) full-length cDNA cloning
Position:
Human AssemblyChrPosition (strand)Source
Build 36126,831,557 - 6,831,617EPD
RGD ID:7222963
Promoter ID:EPDNEW_H17227
Type:initiation region
Name:USP5_1
Description:ubiquitin specific peptidase 5
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh38126,852,150 - 6,852,210EPDNEW


1 to 40 of 55 rows
Database
Acc Id
Source(s)
COSMIC USP5 COSMIC
Ensembl Genes ENSG00000111667 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000229268 ENTREZGENE
  ENST00000229268.13 UniProtKB/Swiss-Prot
  ENST00000389231 ENTREZGENE
  ENST00000389231.9 UniProtKB/Swiss-Prot
Gene3D-CATH 3.30.40.10 UniProtKB/Swiss-Prot
  Cysteine proteinases UniProtKB/Swiss-Prot
  DNA helicase RuvA subunit, C-terminal domain UniProtKB/Swiss-Prot
GTEx ENSG00000111667 GTEx
HGNC ID HGNC:12628 ENTREZGENE
Human Proteome Map USP5 Human Proteome Map
InterPro Papain-like_cys_pep_sf UniProtKB/Swiss-Prot
  Peptidase_C19_UCH UniProtKB/Swiss-Prot
  Ub_carboxyl-term_hydrolase UniProtKB/Swiss-Prot
  UBA UniProtKB/Swiss-Prot
  UBA-like_sf UniProtKB/Swiss-Prot
  Ubiquitinyl_hydrolase UniProtKB/Swiss-Prot
  UBP13_Znf-UBP_var UniProtKB/Swiss-Prot
  UBP5_UBA1 UniProtKB/Swiss-Prot
  USP_CS UniProtKB/Swiss-Prot
  USP_dom UniProtKB/Swiss-Prot
  Znf_RING/FYVE/PHD UniProtKB/Swiss-Prot
  Znf_UBP UniProtKB/Swiss-Prot
KEGG Report hsa:8078 UniProtKB/Swiss-Prot
NCBI Gene 8078 ENTREZGENE
OMIM 601447 OMIM
PANTHER UBIQUITIN CARBOXYL-TERMINAL HYDROLASE UniProtKB/Swiss-Prot
  UBIQUITIN CARBOXYL-TERMINAL HYDROLASE UniProtKB/Swiss-Prot
Pfam UBA_7 UniProtKB/Swiss-Prot
  UCH UniProtKB/Swiss-Prot
  zf-UBP UniProtKB/Swiss-Prot
  zf-UBP_var UniProtKB/Swiss-Prot
PharmGKB PA37253 PharmGKB
PIRSF UBP UniProtKB/Swiss-Prot
PROSITE UBA UniProtKB/Swiss-Prot
  USP_1 UniProtKB/Swiss-Prot
  USP_2 UniProtKB/Swiss-Prot
  USP_3 UniProtKB/Swiss-Prot
  ZF_UBP UniProtKB/Swiss-Prot
1 to 40 of 55 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-04-12 USP5  ubiquitin specific peptidase 5    ubiquitin specific peptidase 5 (isopeptidase T)  Symbol and/or name change 5135510 APPROVED