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Gene: GLUL (glutamate-ammonia ligase) Homo sapiens
Symbol: GLUL
Name: glutamate-ammonia ligase
Description: Exhibits glutamate-ammonia ligase activity; identical protein binding activity; and protein-cysteine S-palmitoyltransferase activity. Involved in several processes, including protein palmitoylation; regulation of endothelial cell migration; and regulation of protein localization to nucleolus. Localizes to cytosol; mitochondrion; and plasma membrane. Implicated in Alzheimer's disease and Huntington's disease. Biomarker of Alzheimer's disease; schizophrenia; and temporal lobe epilepsy.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: cell proliferation-inducing protein 59; GLNS; glutamate decarboxylase; glutamate--ammonia ligase; glutamate-ammonia ligase (glutamine synthase); glutamine synthase; glutamine synthetase; GS; palmitoyltransferase GLUL; PIG43; PIG59; proliferation-inducing protein 43
Mus musculus (house mouse) : Glul (glutamate-ammonia ligase (glutamine synthetase))  MGI  Alliance
Rattus norvegicus (Norway rat) : Glul (glutamate-ammonia ligase)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Glul (glutamate-ammonia ligase)
Pan paniscus (bonobo/pygmy chimpanzee) : GLUL (glutamate-ammonia ligase)
Canis lupus familiaris (dog) : GLUL (glutamate-ammonia ligase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Glul (glutamate-ammonia ligase)
Sus scrofa (pig) : GLUL (glutamate-ammonia ligase)
Chlorocebus sabaeus (African green monkey) : GLUL (glutamate-ammonia ligase)
Heterocephalus glaber (naked mole-rat) : Glul (glutamate-ammonia ligase)
more info ...
Related Pseudogenes: GLULP1   GLULP2   GLULP3   GLULP4   GLULP5   GLULP6  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 Ensembl1182,378,098 - 182,392,206 (-)EnsemblGRCh38hg38GRCh38
GRCh38.p13 Ensembl1182,381,704 - 182,392,206 (-)EnsemblGRCh38hg38GRCh38
GRCh381182,378,098 - 182,391,790 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371182,350,839 - 182,361,341 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361180,618,292 - 180,627,573 (-)NCBINCBI36hg18NCBI36
Build 341179,083,688 - 179,092,561NCBI
Celera1155,461,927 - 155,472,429 (-)NCBI
Cytogenetic Map1q25.3NCBI
HuRef1153,587,169 - 153,597,671 (-)NCBIHuRef
CHM1_11183,770,327 - 183,784,435 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on GLUL
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 730955
Created: 2003-12-10
Species: Homo sapiens
Last Modified: 2020-09-08
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.