STK39 (serine/threonine kinase 39) - Rat Genome Database

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Gene: STK39 (serine/threonine kinase 39) Homo sapiens
Analyze
Symbol: STK39
Name: serine/threonine kinase 39
RGD ID: 734214
HGNC Page HGNC
Description: Enables protein serine/threonine kinase activity. Involved in several processes, including negative regulation of ion transmembrane transporter activity; positive regulation of T cell chemotaxis; and protein phosphorylation. Located in cytosol and nucleoplasm.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: DCHT; DKFZp686K05124; PASK; proline-alanine-rich STE20-related kinase; serine threonine kinase 39 (STE20/SPS1 homolog, yeast); serine/threonine-protein kinase 39; small intestine SPAK-like kinase; SPAK; ste-20-related kinase; Ste20-like protein kinase; STE20/SPS1 homolog; STE20/SPS1-related proline-alanine-rich protein kinase
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl2167,954,020 - 168,247,595 (-)EnsemblGRCh38hg38GRCh38
GRCh382167,954,020 - 168,247,595 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh372168,810,532 - 169,104,105 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362168,518,776 - 168,812,351 (-)NCBINCBI36hg18NCBI36
Build 342168,636,037 - 168,929,612NCBI
Celera2162,419,314 - 162,712,878 (-)NCBI
Cytogenetic Map2q24.3NCBI
HuRef2160,690,590 - 160,918,691 (-)NCBIHuRef
CHM1_12168,816,415 - 169,109,972 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,1-dichloroethene  (ISO)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (EXP)
17beta-hydroxy-17-methylestra-4,9,11-trien-3-one  (EXP)
17beta-hydroxy-5alpha-androstan-3-one  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (ISO)
acetamide  (ISO)
aflatoxin B1  (EXP,ISO)
ammonium chloride  (ISO)
amphetamine  (ISO)
antirheumatic drug  (EXP)
aristolochic acid  (EXP)
Aroclor 1254  (ISO)
arsane  (EXP)
arsenic atom  (EXP)
benzo[a]pyrene  (EXP,ISO)
benzo[e]pyrene  (EXP)
bisphenol A  (EXP,ISO)
calcitriol  (EXP)
carbon nanotube  (ISO)
carboplatin  (ISO)
choline  (ISO)
cisplatin  (EXP,ISO)
cobalt dichloride  (EXP)
copper(II) sulfate  (EXP)
cyclophosphamide  (EXP)
cyclosporin A  (EXP)
dactolisib  (ISO)
daidzein  (EXP)
dorsomorphin  (EXP)
doxorubicin  (EXP)
enzyme inhibitor  (EXP)
eplerenone  (ISO)
equol  (EXP)
ethanol  (ISO)
flavonoids  (ISO)
folic acid  (EXP,ISO)
fulvestrant  (EXP)
furan  (ISO)
genistein  (EXP)
gentamycin  (ISO)
hydrogen peroxide  (EXP)
ivermectin  (EXP)
L-methionine  (ISO)
methapyrilene  (EXP)
methoxyacetic acid  (ISO)
N,N-diethyl-m-toluamide  (ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (EXP)
N-nitrosomorpholine  (ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
PCB138  (ISO)
permethrin  (ISO)
phenylmercury acetate  (EXP)
pirinixic acid  (EXP,ISO)
piroxicam  (EXP)
pregnenolone 16alpha-carbonitrile  (ISO)
Rebamipide  (ISO)
resveratrol  (EXP)
rifampicin  (EXP)
Salinomycin  (EXP)
SB 431542  (EXP)
sodium arsenite  (EXP)
sodium fluoride  (ISO)
temozolomide  (EXP)
tetrachloromethane  (ISO)
thioacetamide  (ISO)
trimellitic anhydride  (ISO)
urethane  (EXP)
valproic acid  (EXP,ISO)
venlafaxine hydrochloride  (ISO)
zinc atom  (EXP)
zinc(0)  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

Additional References at PubMed
PMID:11514053   PMID:12386165   PMID:12740379   PMID:14563843   PMID:14702039   PMID:15930150   PMID:16263722   PMID:16530727   PMID:16669787   PMID:16950202   PMID:16964243   PMID:17081983  
PMID:17321610   PMID:18270262   PMID:18348195   PMID:18550547   PMID:18787102   PMID:19114657   PMID:19343169   PMID:19414679   PMID:19470686   PMID:19717643   PMID:20003416   PMID:20379614  
PMID:20442269   PMID:20555294   PMID:20889219   PMID:21178783   PMID:21292315   PMID:21317537   PMID:21321328   PMID:21423148   PMID:21442361   PMID:21705622   PMID:21873635   PMID:22779921  
PMID:22863883   PMID:23034389   PMID:23151749   PMID:23235358   PMID:23527223   PMID:23759979   PMID:23894895   PMID:24133122   PMID:24191005   PMID:24312176   PMID:24393035   PMID:24631562  
PMID:24655550   PMID:24722188   PMID:24873805   PMID:25064009   PMID:25164821   PMID:25323061   PMID:25362046   PMID:25515571   PMID:25531585   PMID:25963833   PMID:25994507   PMID:26112741  
PMID:26186194   PMID:26233565   PMID:26416847   PMID:26469904   PMID:26496610   PMID:26506223   PMID:26584301   PMID:26662444   PMID:26673921   PMID:26911228   PMID:26914237   PMID:27082544  
PMID:27122160   PMID:27142475   PMID:27320910   PMID:27337956   PMID:27400149   PMID:27432908   PMID:27542260   PMID:28380382   PMID:28514442   PMID:28945285   PMID:29367247   PMID:29564728  
PMID:30021884   PMID:30060950   PMID:31091453   PMID:31614064   PMID:31678930   PMID:31753913   PMID:31980649   PMID:32020227   PMID:32109341   PMID:32828531   PMID:34335956  


Genomics

Comparative Map Data
STK39
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl2167,954,020 - 168,247,595 (-)EnsemblGRCh38hg38GRCh38
GRCh382167,954,020 - 168,247,595 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh372168,810,532 - 169,104,105 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362168,518,776 - 168,812,351 (-)NCBINCBI36hg18NCBI36
Build 342168,636,037 - 168,929,612NCBI
Celera2162,419,314 - 162,712,878 (-)NCBI
Cytogenetic Map2q24.3NCBI
HuRef2160,690,590 - 160,918,691 (-)NCBIHuRef
CHM1_12168,816,415 - 169,109,972 (-)NCBICHM1_1
Stk39
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39268,040,789 - 68,302,625 (-)NCBIGRCm39mm39
GRCm39 Ensembl268,040,789 - 68,302,612 (-)Ensembl
GRCm38268,210,445 - 68,472,108 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl268,210,445 - 68,472,268 (-)EnsemblGRCm38mm10GRCm38
MGSCv37268,048,504 - 68,310,038 (-)NCBIGRCm37mm9NCBIm37
MGSCv36268,011,286 - 68,272,820 (-)NCBImm8
Celera269,878,607 - 70,140,879 (-)NCBICelera
Cytogenetic Map2C1.3NCBI
Stk39
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2352,913,583 - 53,179,060 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl352,913,585 - 53,179,060 (-)Ensembl
Rnor_6.0354,359,449 - 54,625,702 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl354,359,451 - 54,625,414 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0360,973,443 - 61,244,306 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4350,249,626 - 50,517,085 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1350,297,966 - 50,413,457 (-)NCBI
Celera352,482,845 - 52,746,814 (-)NCBICelera
Cytogenetic Map3q21NCBI
Stk39
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554496,167,752 - 6,390,736 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554496,112,726 - 6,387,925 (+)NCBIChiLan1.0ChiLan1.0
STK39
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.12B172,674,514 - 172,904,723 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B172,674,514 - 172,970,063 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v02B55,204,203 - 55,501,033 (-)NCBIMhudiblu_PPA_v0panPan3
STK39
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13612,866,867 - 13,118,736 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3612,867,188 - 13,183,160 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3612,875,995 - 13,167,194 (-)NCBI
ROS_Cfam_1.03612,983,192 - 13,273,757 (-)NCBI
UMICH_Zoey_3.13613,068,051 - 13,358,464 (-)NCBI
UNSW_CanFamBas_1.03613,054,289 - 13,344,871 (-)NCBI
UU_Cfam_GSD_1.03613,165,580 - 13,457,184 (-)NCBI
Stk39
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303130,101,476 - 130,374,107 (-)NCBI
SpeTri2.0NW_00493646911,274,398 - 11,516,244 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
STK39
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1574,408,273 - 74,758,122 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11574,441,019 - 74,757,851 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21583,412,068 - 83,666,888 (-)NCBISscrofa10.2Sscrofa10.2susScr3
STK39
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11053,451,035 - 53,747,847 (-)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl1053,450,891 - 53,682,993 (-)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666040145,776,885 - 146,078,123 (+)NCBIVero_WHO_p1.0
Stk39
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247875,682,023 - 5,966,770 (-)NCBIHetGla_female_1.0hetGla2

Position Markers
SHGC-32064  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh372168,815,964 - 168,816,108UniSTSGRCh37
Build 362168,524,210 - 168,524,354RGDNCBI36
Celera2162,424,748 - 162,424,892RGD
Cytogenetic Map2q24.3UniSTS
HuRef2160,696,021 - 160,696,165UniSTS
GeneMap99-GB4 RH Map2554.87UniSTS
Whitehead-RH Map2889.7UniSTS
NCBI RH Map21278.1UniSTS
GeneMap99-G3 RH Map27702.0UniSTS
RH99072  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh372168,810,781 - 168,810,949UniSTSGRCh37
Build 362168,519,027 - 168,519,195RGDNCBI36
Celera2162,419,565 - 162,419,733RGD
Cytogenetic Map2q24.3UniSTS
HuRef2160,690,841 - 160,691,009UniSTS
GeneMap99-GB4 RH Map2555.09UniSTS
SHGC-104962  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh372168,848,725 - 168,849,051UniSTSGRCh37
Build 362168,556,971 - 168,557,297RGDNCBI36
Celera2162,457,519 - 162,457,845RGD
Cytogenetic Map2q24.3UniSTS
HuRef2160,728,780 - 160,729,106UniSTS
TNG Radiation Hybrid Map2124636.0UniSTS
SHGC-149406  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh372168,846,072 - 168,846,350UniSTSGRCh37
Build 362168,554,318 - 168,554,596RGDNCBI36
Celera2162,454,841 - 162,455,119RGD
Cytogenetic Map2q24.3UniSTS
HuRef2160,726,127 - 160,726,405UniSTS
TNG Radiation Hybrid Map2124621.0UniSTS
SHGC-144147  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh372168,906,488 - 168,906,768UniSTSGRCh37
Build 362168,614,734 - 168,615,014RGDNCBI36
Celera2162,515,280 - 162,515,560RGD
Cytogenetic Map2q24.3UniSTS
HuRef2160,786,540 - 160,786,820UniSTS
TNG Radiation Hybrid Map2124604.0UniSTS
SHGC-145855  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh372169,044,142 - 169,044,413UniSTSGRCh37
Build 362168,752,388 - 168,752,659RGDNCBI36
Celera2162,652,938 - 162,653,209RGD
Cytogenetic Map2q24.3UniSTS
HuRef2160,924,231 - 160,924,502UniSTS
TNG Radiation Hybrid Map2124713.0UniSTS
SHGC-70162  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh372168,833,581 - 168,833,872UniSTSGRCh37
Build 362168,541,827 - 168,542,118RGDNCBI36
Celera2162,442,364 - 162,442,655RGD
Cytogenetic Map2q24.3UniSTS
HuRef2160,713,639 - 160,713,930UniSTS
TNG Radiation Hybrid Map2124621.0UniSTS
26  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh372169,086,895 - 169,087,021UniSTSGRCh37
Build 362168,795,141 - 168,795,267RGDNCBI36
Celera2162,695,694 - 162,695,820RGD
Cytogenetic Map2q24.3UniSTS
HuRef2160,966,898 - 160,967,024UniSTS
GeneMap99-GB4 RH Map2553.29UniSTS
RH68427  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh372168,811,852 - 168,812,007UniSTSGRCh37
Build 362168,520,098 - 168,520,253RGDNCBI36
Celera2162,420,636 - 162,420,791RGD
Cytogenetic Map2q24.3UniSTS
HuRef2160,691,912 - 160,692,067UniSTS
GeneMap99-GB4 RH Map2550.37UniSTS
RH69463  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh372169,094,388 - 169,094,536UniSTSGRCh37
Build 362168,802,634 - 168,802,782RGDNCBI36
Celera2162,703,186 - 162,703,334RGD
Cytogenetic Map2q24.3UniSTS
HuRef2160,974,390 - 160,974,538UniSTS
GeneMap99-GB4 RH Map2550.37UniSTS
NCBI RH Map21319.4UniSTS
RH11654  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh372168,816,110 - 168,816,298UniSTSGRCh37
Build 362168,524,356 - 168,524,544RGDNCBI36
Celera2162,424,894 - 162,425,082RGD
Cytogenetic Map2q24.3UniSTS
HuRef2160,696,167 - 160,696,355UniSTS
GeneMap99-GB4 RH Map2554.98UniSTS
NCBI RH Map21275.8UniSTS
D16S325  
Human AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map9q34.13UniSTS
Cytogenetic Map9q22.33UniSTS
Cytogenetic Map20p13UniSTS
Cytogenetic Map4q21.1UniSTS
Cytogenetic Map6q25.3UniSTS
Cytogenetic Map2q32.3UniSTS
Cytogenetic Map6q22UniSTS
Cytogenetic Map12q24.31UniSTS
Cytogenetic Map17q21.2-q21.3UniSTS
Cytogenetic Map13q14.3UniSTS
Cytogenetic Map17q11.2UniSTS
Cytogenetic Map2q33.3UniSTS
Cytogenetic Map20q13.32UniSTS
Cytogenetic Map1p21.2UniSTS
Cytogenetic Map1p35.1UniSTS
Cytogenetic Map12q13.2UniSTS
Cytogenetic Map17q12UniSTS
Cytogenetic Map19p13.12UniSTS
Cytogenetic Map12p13.32UniSTS
Cytogenetic Map19p13.3UniSTS
Cytogenetic Map17p13.2UniSTS
Cytogenetic Map8q22.3UniSTS
Cytogenetic Map5q35.3UniSTS
Cytogenetic Map1p13.1UniSTS
Cytogenetic Map7q22.1UniSTS
Cytogenetic Map4q25UniSTS
Cytogenetic Map19q13.32UniSTS
Cytogenetic Map7p22.2UniSTS
Cytogenetic Map7q33UniSTS
Cytogenetic Map1p31.3UniSTS
Cytogenetic Map16q24.1UniSTS
Cytogenetic Map6q13UniSTS
Cytogenetic Map4p16.3UniSTS
Cytogenetic Map2q35UniSTS
Cytogenetic Map10q11.2UniSTS
Cytogenetic Map7q11.23UniSTS
Cytogenetic Map3q13.32UniSTS
Cytogenetic Map19p12UniSTS
Cytogenetic Map19p13.11UniSTS
Cytogenetic Map19q13.41UniSTS
Cytogenetic Map6p22.3UniSTS
Cytogenetic Map12q22UniSTS
Cytogenetic Map21q22.3UniSTS
Cytogenetic Map3q22.1UniSTS
Cytogenetic Map19p13.2UniSTS
Cytogenetic Map6q25.2-q25.3UniSTS
Cytogenetic Map1p36.1UniSTS
Cytogenetic Map22q11.2UniSTS
Cytogenetic Map3q26.31UniSTS
Cytogenetic Map7p12.3UniSTS
Cytogenetic Map4q12UniSTS
Cytogenetic Map5p12UniSTS
Cytogenetic Map9q21.13UniSTS
Cytogenetic Map17q21.33UniSTS
Cytogenetic Map20p12.3-p11.21UniSTS
Cytogenetic Map11q13UniSTS
Cytogenetic Map2p13-p12UniSTS
Cytogenetic Map1q32UniSTS
Cytogenetic Map7p13UniSTS
Cytogenetic Map4q22.1UniSTS
Cytogenetic Map3q25.33UniSTS
Cytogenetic Map2q33.2UniSTS
Cytogenetic Map7p11.2UniSTS
Cytogenetic Map8q21.13UniSTS
Cytogenetic Map7q32.1UniSTS
Cytogenetic Map8p21.3UniSTS
Cytogenetic Map17q22UniSTS
Cytogenetic Map3p24.2UniSTS
Cytogenetic Map8q24.3UniSTS
Cytogenetic Map14q32UniSTS
Cytogenetic MapXp22.33UniSTS
Cytogenetic MapYp11.32UniSTS
Cytogenetic Map10q24.31UniSTS
Cytogenetic Map4q34.3UniSTS
Cytogenetic Map10p11.23UniSTS
Cytogenetic Map10p15.1UniSTS
Cytogenetic Map14q21.2UniSTS
Cytogenetic Map6p21.31UniSTS
Cytogenetic Map9p24.1-p23UniSTS
Cytogenetic Map15q15.3UniSTS
Cytogenetic Map12q12UniSTS
Cytogenetic Map5q32UniSTS
Cytogenetic Map10pter-q25.3UniSTS
Cytogenetic Map6q25.2-q27UniSTS
Cytogenetic Map15q26.3UniSTS
Cytogenetic Map15q14UniSTS
Cytogenetic Map2p23.3UniSTS
Cytogenetic Map19q13.12UniSTS
Cytogenetic Map3q23UniSTS
Cytogenetic Map1q21.2UniSTS
Cytogenetic Map1q21.3UniSTS
Cytogenetic Map11p11.2UniSTS
Cytogenetic Map17q21.32UniSTS
Cytogenetic Map11p15.5UniSTS
Cytogenetic Map7p15.3UniSTS
Cytogenetic Map7p21.1UniSTS
Cytogenetic Map17q23.2UniSTS
Cytogenetic Map11q13.2UniSTS
Cytogenetic Map1p36.3-p34.3UniSTS
Cytogenetic Map1p13.3UniSTS
Cytogenetic Map4p15.2UniSTS
Cytogenetic Map3p25.3UniSTS
Cytogenetic Map2p11.2UniSTS
Cytogenetic Map2q24.3UniSTS
Cytogenetic Map1q25.2UniSTS
Cytogenetic Map6q27UniSTS
Cytogenetic Map12q14.3UniSTS
Cytogenetic Map19q13.3UniSTS
Cytogenetic Map22q13.1UniSTS
Cytogenetic Map6p21.1UniSTS
Cytogenetic Map17p11.2UniSTS
Cytogenetic Map3q27.1UniSTS
Cytogenetic Map15q11.2UniSTS
Cytogenetic Map6p21.33UniSTS
Cytogenetic Map20q11.23UniSTS
Cytogenetic Map2q12.2UniSTS
Cytogenetic Map11q13.4UniSTS
Cytogenetic Map3p26UniSTS
Cytogenetic MapXq28UniSTS
Cytogenetic Map3p14.3UniSTS
Cytogenetic Map17q25.1UniSTS
Cytogenetic Map10q21-q22UniSTS
Cytogenetic Map5q22UniSTS
Cytogenetic Map19q13.43UniSTS
Cytogenetic Map10q22.2UniSTS
Cytogenetic Map8p22UniSTS
Cytogenetic Map22q11.23UniSTS
Cytogenetic Map16q22.1UniSTS
Cytogenetic Map12q14.2UniSTS
Cytogenetic Map11q22.3UniSTS
Cytogenetic Map10q26.11UniSTS
Cytogenetic Map10q25.3UniSTS
Cytogenetic Map6q22.32UniSTS
Cytogenetic Map20q13.12UniSTS
Cytogenetic Map1q21.1UniSTS
Cytogenetic Map19q13.31UniSTS
Cytogenetic Map17p13.1UniSTS
Cytogenetic Map12q23.3UniSTS
Cytogenetic Map3q21UniSTS
Cytogenetic Map3q21.3UniSTS
Cytogenetic Map17q21.31UniSTS
Cytogenetic Map13q14.11UniSTS
Cytogenetic Map7q36UniSTS
Cytogenetic Map4q26UniSTS
Cytogenetic Map19qterUniSTS
Cytogenetic Map7p13-p12UniSTS
Cytogenetic Map2p22UniSTS
Cytogenetic Map2q14.3UniSTS
Cytogenetic Map19q13.4UniSTS

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:760
Count of miRNA genes:573
Interacting mature miRNAs:633
Transcripts:ENST00000355999, ENST00000461000, ENST00000487143
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component
High
Medium 2329 1516 781 236 628 79 3140 1049 3407 299 1186 949 170 1143 1853
Low 102 1461 874 318 1149 317 1211 1142 305 119 263 661 2 1 61 931 3
Below cutoff 5 10 68 68 162 69 4 4 8 1 4 1 4

Sequence

Nucleotide Sequences
RefSeq Transcripts NG_052783 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_013233 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_005246465 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017003813 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017003814 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017003815 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017003816 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017003817 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC016723 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC017069 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC067940 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF017635 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF030403 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF099989 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK126343 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC146813 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BF516344 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BX647113 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BX648046 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471058 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ537524 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KJ534948 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KJ534949 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KJ534950 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KJ534951 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KJ534999 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KJ535059 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000355999   ⟹   ENSP00000348278
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl2167,954,022 - 168,247,595 (-)Ensembl
RefSeq Acc Id: ENST00000461000
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl2167,964,308 - 168,012,661 (-)Ensembl
RefSeq Acc Id: ENST00000487143
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl2167,954,020 - 168,113,106 (-)Ensembl
RefSeq Acc Id: NM_013233   ⟹   NP_037365
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh382167,954,022 - 168,247,595 (-)NCBI
GRCh372168,810,530 - 169,104,105 (-)ENTREZGENE
GRCh372168,810,530 - 169,104,105 (-)NCBI
Build 362168,518,776 - 168,812,351 (-)NCBI Archive
HuRef2160,690,590 - 160,918,691 (-)ENTREZGENE
CHM1_12168,816,415 - 169,109,972 (-)NCBI
Sequence:
RefSeq Acc Id: XM_005246465   ⟹   XP_005246522
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh382167,954,020 - 168,247,541 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017003813   ⟹   XP_016859302
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh382167,959,292 - 168,247,541 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017003814   ⟹   XP_016859303
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh382168,035,412 - 168,247,541 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017003815   ⟹   XP_016859304
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh382167,954,980 - 168,224,021 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017003816   ⟹   XP_016859305
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh382168,110,503 - 168,247,541 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017003817   ⟹   XP_016859306
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh382167,954,980 - 168,163,732 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_037365   ⟸   NM_013233
- UniProtKB: Q9UEW8 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_005246522   ⟸   XM_005246465
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_016859304   ⟸   XM_017003815
- Peptide Label: isoform X4
- Sequence:
RefSeq Acc Id: XP_016859306   ⟸   XM_017003817
- Peptide Label: isoform X6
- Sequence:
RefSeq Acc Id: XP_016859302   ⟸   XM_017003813
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_016859303   ⟸   XM_017003814
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_016859305   ⟸   XM_017003816
- Peptide Label: isoform X5
- Sequence:
RefSeq Acc Id: ENSP00000348278   ⟸   ENST00000355999
Protein Domains
Protein kinase

Promoters
RGD ID:6861934
Promoter ID:EPDNEW_H4132
Type:initiation region
Name:STK39_1
Description:serine/threonine kinase 39
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh382168,247,595 - 168,247,655EPDNEW
RGD ID:6798292
Promoter ID:HG_KWN:35758
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   HeLa_S3,   Jurkat,   NB4
Transcripts:OTTHUMT00000258112,   OTTHUMT00000333228
Position:
Human AssemblyChrPosition (strand)Source
Build 362168,812,249 - 168,812,749 (-)MPROMDB

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 2q24.3-31.1(chr2:164850117-175559190)x1 copy number loss See cases [RCV000051201] Chr2:164850117..175559190 [GRCh38]
Chr2:165706627..176423918 [GRCh37]
Chr2:165414873..176132164 [NCBI36]
Chr2:2q24.3-31.1
pathogenic
GRCh38/hg38 2q24.3-32.1(chr2:163965382-182195062)x1 copy number loss See cases [RCV000054122] Chr2:163965382..182195062 [GRCh38]
Chr2:164821892..183059789 [GRCh37]
Chr2:164530138..182768034 [NCBI36]
Chr2:2q24.3-32.1
pathogenic
GRCh38/hg38 2q24.3-31.1(chr2:164066038-172097886)x1 copy number loss See cases [RCV000054123] Chr2:164066038..172097886 [GRCh38]
Chr2:164922548..172962614 [GRCh37]
Chr2:164630794..172670860 [NCBI36]
Chr2:2q24.3-31.1
pathogenic
GRCh38/hg38 2q24.3-31.1(chr2:165209651-169567892)x1 copy number loss Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000054124]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000054124]|See cases [RCV000054124] Chr2:165209651..169567892 [GRCh38]
Chr2:166066161..170424402 [GRCh37]
Chr2:165774407..170132648 [NCBI36]
Chr2:2q24.3-31.1
pathogenic
NM_013233.2(STK39):c.1376+17482A>G single nucleotide variant Lung cancer [RCV000091650] Chr2:168046018 [GRCh38]
Chr2:168902528 [GRCh37]
Chr2:2q24.3
uncertain significance
NM_013233.2(STK39):c.1376+11161A>G single nucleotide variant Lung cancer [RCV000091651] Chr2:168052339 [GRCh38]
Chr2:168908849 [GRCh37]
Chr2:2q24.3
uncertain significance
NM_013233.2(STK39):c.1090-14704T>C single nucleotide variant Lung cancer [RCV000091652] Chr2:168089935 [GRCh38]
Chr2:168946445 [GRCh37]
Chr2:2q24.3
uncertain significance
NM_013233.2(STK39):c.975-2584G>T single nucleotide variant Lung cancer [RCV000091653] Chr2:168132342 [GRCh38]
Chr2:168988852 [GRCh37]
Chr2:2q24.3
uncertain significance
NM_013233.2(STK39):c.841-535C>T single nucleotide variant Lung cancer [RCV000091654] Chr2:168138756 [GRCh38]
Chr2:168995266 [GRCh37]
Chr2:2q24.3
uncertain significance
GRCh38/hg38 2q24.1-31.1(chr2:154294042-175989372)x3 copy number gain See cases [RCV000142286] Chr2:154294042..175989372 [GRCh38]
Chr2:155150555..176854100 [GRCh37]
Chr2:154858801..176562346 [NCBI36]
Chr2:2q24.1-31.1
pathogenic
GRCh38/hg38 2q24.3(chr2:167995450-168840081)x3 copy number gain See cases [RCV000142874] Chr2:167995450..168840081 [GRCh38]
Chr2:168851960..169696591 [GRCh37]
Chr2:168560206..169404837 [NCBI36]
Chr2:2q24.3
likely benign
GRCh37/hg19 2q24.3-31.1(chr2:167996718-170671886)x1 copy number loss See cases [RCV000167568] Chr2:167996718..170671886 [GRCh37]
Chr2:2q24.3-31.1
likely pathogenic
GRCh37/hg19 2q24.1-31.3(chr2:156489430-182921298)x3 copy number gain See cases [RCV000239848] Chr2:156489430..182921298 [GRCh37]
Chr2:2q24.1-31.3
pathogenic
NM_013233.3(STK39):c.54_69del (p.Pro19fs) deletion not provided [RCV000332811] Chr2:168247367..168247382 [GRCh38]
Chr2:169103877..169103892 [GRCh37]
Chr2:2q24.3
uncertain significance
GRCh37/hg19 2q24.3-31.1(chr2:165173620-169779326)x1 copy number loss not provided [RCV000585557] Chr2:165173620..169779326 [GRCh37]
Chr2:2q24.3-31.1
likely pathogenic
GRCh37/hg19 2p25.3-q37.3(chr2:12771-242783384) copy number gain See cases [RCV000512056] Chr2:12771..242783384 [GRCh37]
Chr2:2p25.3-q37.3
pathogenic
GRCh37/hg19 2q24.3(chr2:166374955-169671203)x1 copy number loss See cases [RCV000511973] Chr2:166374955..169671203 [GRCh37]
Chr2:2q24.3
pathogenic
GRCh37/hg19 2q24.3(chr2:164366067-169069454)x1 copy number loss See cases [RCV000511424] Chr2:164366067..169069454 [GRCh37]
Chr2:2q24.3
pathogenic
GRCh37/hg19 2p25.3-q37.3(chr2:12771-242783384)x3 copy number gain See cases [RCV000511212] Chr2:12771..242783384 [GRCh37]
Chr2:2p25.3-q37.3
pathogenic
GRCh37/hg19 2q24.1-24.3(chr2:157970774-169270675)x1 copy number loss See cases [RCV000512264] Chr2:157970774..169270675 [GRCh37]
Chr2:2q24.1-24.3
pathogenic
GRCh37/hg19 2p25.3-q37.3(chr2:14238-243048760)x3 copy number gain not provided [RCV000752802] Chr2:14238..243048760 [GRCh37]
Chr2:2p25.3-q37.3
pathogenic
GRCh37/hg19 2p25.3-q37.3(chr2:15672-243101834)x3 copy number gain not provided [RCV000752804] Chr2:15672..243101834 [GRCh37]
Chr2:2p25.3-q37.3
pathogenic
GRCh37/hg19 2q23.3-31.2(chr2:152409978-179325736)x3 copy number gain not provided [RCV000740654] Chr2:152409978..179325736 [GRCh37]
Chr2:2q23.3-31.2
pathogenic
NM_013233.3(STK39):c.87G>C (p.Ala29=) single nucleotide variant not provided [RCV000968548] Chr2:168247349 [GRCh38]
Chr2:169103859 [GRCh37]
Chr2:2q24.3
likely benign
NM_013233.3(STK39):c.126CCCGGC[5] (p.43PA[5]) microsatellite not provided [RCV000948248] Chr2:168247286..168247287 [GRCh38]
Chr2:169103796..169103797 [GRCh37]
Chr2:2q24.3
benign
GRCh37/hg19 2q24.3(chr2:168900871-168981256)x1 copy number loss not provided [RCV000845943] Chr2:168900871..168981256 [GRCh37]
Chr2:2q24.3
uncertain significance
GRCh37/hg19 2q24.3(chr2:168768007-168982598)x1 copy number loss not provided [RCV000848535] Chr2:168768007..168982598 [GRCh37]
Chr2:2q24.3
uncertain significance
GRCh37/hg19 2q24.3(chr2:168720194-168815511)x3 copy number gain not provided [RCV000846761] Chr2:168720194..168815511 [GRCh37]
Chr2:2q24.3
uncertain significance
GRCh37/hg19 2q24.3-32.3(chr2:167329586-192756373)x1 copy number loss not provided [RCV000848216] Chr2:167329586..192756373 [GRCh37]
Chr2:2q24.3-32.3
pathogenic
GRCh37/hg19 2q24.2-34(chr2:163233162-211927188)x3 copy number gain not provided [RCV001005349] Chr2:163233162..211927188 [GRCh37]
Chr2:2q24.2-34
pathogenic
GRCh37/hg19 2q24.2-31.3(chr2:163078055-182119617)x1 copy number loss 2q24 microdeletion syndrome [RCV001263223] Chr2:163078055..182119617 [GRCh37]
Chr2:2q24.2-31.3
pathogenic
GRCh37/hg19 2q24.3(chr2:168619461-168857853)x3 copy number gain not provided [RCV001258558] Chr2:168619461..168857853 [GRCh37]
Chr2:2q24.3
uncertain significance

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:17717 AgrOrtholog
COSMIC STK39 COSMIC
Ensembl Genes ENSG00000198648 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSP00000348278 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000355999 ENTREZGENE, UniProtKB/Swiss-Prot
GTEx ENSG00000198648 GTEx
HGNC ID HGNC:17717 ENTREZGENE
Human Proteome Map STK39 Human Proteome Map
InterPro Kinase-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kinase_OSR1/WNK_CCT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:27347 UniProtKB/Swiss-Prot
NCBI Gene 27347 ENTREZGENE
OMIM 607648 OMIM
Pfam OSR1_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pkinase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA38243 PharmGKB
PROSITE PROTEIN_KINASE_ATP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART S_TKc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF56112 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt Q9UEW8 ENTREZGENE, UniProtKB/Swiss-Prot
  X5D2U3_HUMAN UniProtKB/TrEMBL
  X5D2Y0_HUMAN UniProtKB/TrEMBL
  X5D7P8_HUMAN UniProtKB/TrEMBL
  X5D9L8_HUMAN UniProtKB/TrEMBL
  X5DP03_HUMAN UniProtKB/TrEMBL
UniProt Secondary O14774 UniProtKB/Swiss-Prot
  Q53S90 UniProtKB/Swiss-Prot
  Q53SL7 UniProtKB/Swiss-Prot
  Q53SS1 UniProtKB/Swiss-Prot
  Q9UER4 UniProtKB/Swiss-Prot
  X5D9C8 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-11-24 STK39  serine/threonine kinase 39    serine threonine kinase 39  Symbol and/or name change 5135510 APPROVED
2011-08-17 STK39  serine threonine kinase 39  STK39  serine threonine kinase 39  Symbol and/or name change 5135510 APPROVED
2011-07-27 STK39  serine threonine kinase 39  STK39  serine threonine kinase 39 (STE20/SPS1 homolog, yeast)  Symbol and/or name change 5135510 APPROVED