CLU (clusterin) - Rat Genome Database

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Gene: CLU (clusterin) Homo sapiens
Analyze
Symbol: CLU
Name: clusterin
RGD ID: 68978
HGNC Page HGNC
Description: Exhibits several functions, including amyloid-beta binding activity; low-density lipoprotein particle receptor binding activity; and misfolded protein binding activity. Involved in several processes, including positive regulation of cellular component organization; regulation of intrinsic apoptotic signaling pathway; and regulation of protein metabolic process. Localizes to several cellular components, including neurofibrillary tangle; perinuclear endoplasmic reticulum lumen; and spherical high-density lipoprotein particle. Colocalizes with cell periphery; cytoskeleton; and membrane. Implicated in artery disease (multiple); breast cancer; diabetic retinopathy; exfoliation syndrome; and muscular disease (multiple). Biomarker of several diseases, including Kawasaki disease; Stevens-Johnson syndrome; autoimmune disease of musculoskeletal system (multiple); eye disease (multiple); and invasive ductal carcinoma.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: AAG4; aging-associated protein 4; APO-J; APOJ; apolipoprotein J; CLI; CLU1; CLU2; complement cytolysis inhibitor; complement lysis inhibitor; complement-associated protein SP-40,40; ku70-binding protein 1; KUB1; MGC24903; NA1/NA2; SGP-2; SGP2; SP-40; sulfated glycoprotein 2; testosterone-repressed prostate message 2; TRPM-2; TRPM2
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl827,596,917 - 27,614,700 (-)EnsemblGRCh38hg38GRCh38
GRCh38827,596,917 - 27,614,700 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37827,454,434 - 27,472,217 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36827,510,368 - 27,528,244 (-)NCBINCBI36hg18NCBI36
Build 34827,510,367 - 27,524,855NCBI
Celera826,414,541 - 26,432,416 (-)NCBI
Cytogenetic Map8p21.1NCBI
HuRef825,999,468 - 26,017,387 (-)NCBIHuRef
CHM1_1827,656,307 - 27,674,217 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
acute kidney failure  (EXP,ISO)
Alzheimer's disease  (EXP,IAGP,IEP)
amyotrophic lateral sclerosis type 1  (EXP)
anti-basement membrane glomerulonephritis  (ISO)
atherosclerosis  (IDA)
Atrophy  (EXP)
brain ischemia  (ISO)
breast cancer  (IAGP)
Breast Neoplasms  (IEP,IMP)
Chemical and Drug Induced Liver Injury  (EXP)
Chronic Allograft Nephropathy  (ISO)
chronic kidney disease  (ISO)
cicatricial pemphigoid  (IEP)
Cognitive Dysfunction  (EXP)
conjunctival disease  (IEP)
coronary artery disease  (IEP)
Diabetic Nephropathies  (ISO)
diabetic retinopathy  (IDA)
Drug-Related Side Effects and Adverse Reactions  (EXP)
exfoliation syndrome  (IAGP,IEP)
Experimental Diabetes Mellitus  (ISO)
Fuchs' endothelial dystrophy  (IEP,ISO)
gelatinous drop-like corneal dystrophy  (IEP)
Hyperplasia  (IEP)
hypertension  (IAGP)
inclusion body myositis  (IDA)
invasive ductal carcinoma  (IEP)
iron metabolism disease  (ISO)
juvenile rheumatoid arthritis  (EXP)
Kawasaki disease  (IEP)
kidney disease  (EXP)
lupus nephritis  (ISO)
Lymphatic Metastasis  (IAGP)
macular retinal edema  (IEP)
Mammary Neoplasms, Experimental  (IMP)
melanoma  (EXP)
muscular disease  (IDA)
mycosis fungoides  (IEP)
myocardial infarction  (IDA)
nasal cavity adenocarcinoma  (IEP)
Neointima  (ISO)
Neoplasm Metastasis  (IMP)
Neovascularization, Pathologic  (EXP)
Optic Nerve Injuries  (ISO)
osteoarthritis  (EXP)
Pituitary Neoplasms  (ISO)
pre-eclampsia  (IAGP)
prostate adenocarcinoma  (ISO)
prostatic hypertrophy  (ISO)
Prostatic Neoplasms  (EXP)
proteinuria  (ISO)
psoriasis  (IEP)
pulmonary hypertension  (ISO)
renal fibrosis  (ISO)
Retina Reperfusion Injury  (ISO)
retinal degeneration  (ISO)
skin papilloma  (ISO)
squamous cell carcinoma  (ISO)
Stevens-Johnson syndrome  (IEP)
systemic lupus erythematosus  (EXP,IEP)
systemic scleroderma  (IEP)
visual epilepsy  (EXP)
vitiligo  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(S)-ropivacaine  (EXP)
1,1'-azobis(N,N-dimethylformamide)  (EXP)
1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane  (ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (ISO)
1-nitropyrene  (EXP)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (ISO)
17beta-hydroxy-17-methylestra-4,9,11-trien-3-one  (EXP)
17beta-hydroxy-5alpha-androstan-3-one  (EXP)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,2,2-tetramine  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3-dimethoxynaphthalene-1,4-dione  (EXP)
2,5-hexanedione  (ISO)
2-(3,4-dimethoxyphenyl)-5-\{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino\}-2-(propan-2-yl)pentanenitrile  (EXP)
2-acetamidofluorene  (ISO)
2-hydroxypropanoic acid  (EXP)
2-methoxyethanol  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,3',4,4'-tetrachlorobiphenyl  (ISO)
3,3',5-triiodo-L-thyronine  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-Dichlorobenzophenone  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-tert-Octylphenol  (ISO)
5-aza-2'-deoxycytidine  (EXP)
6-propyl-2-thiouracil  (ISO)
acrylamide  (EXP)
aflatoxin B1  (EXP,ISO)
aflatoxin B2  (EXP)
all-trans-retinoic acid  (EXP,ISO)
allethrin  (ISO)
aluminium oxide  (ISO)
ammonia  (ISO)
ammonium chloride  (EXP,ISO)
amphotericin B  (ISO)
antirheumatic drug  (EXP)
arsenous acid  (EXP)
bacitracin  (ISO)
bathocuproine disulfonic acid  (EXP)
belinostat  (EXP)
benzene  (EXP)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (EXP)
bicalutamide  (EXP)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bortezomib  (EXP)
cadmium atom  (EXP,ISO)
cadmium dichloride  (ISO)
calcitriol  (EXP)
carbendazim  (ISO)
carbon nanotube  (ISO)
carboplatin  (ISO)
chloroform  (ISO)
chloroquine  (ISO)
cisplatin  (EXP,ISO)
clofibrate  (ISO)
cobalt dichloride  (EXP)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) chloride  (EXP,ISO)
copper(II) sulfate  (EXP)
coumestrol  (EXP)
crocidolite asbestos  (ISO)
CU-O LINKAGE  (EXP)
cumene  (ISO)
cyanuric acid  (ISO)
cyclosporin A  (EXP,ISO)
cyhalothrin  (ISO)
cypermethrin  (ISO)
D-penicillamine  (EXP)
dacarbazine  (EXP)
daidzein  (ISO)
DDE  (EXP,ISO)
DDT  (ISO)
deferasirox  (ISO)
depsipeptide  (EXP)
dexamethasone  (EXP,ISO)
diarsenic trioxide  (EXP)
dibenzoylmethane  (ISO)
dibutyl phthalate  (ISO)
dichlorine  (ISO)
diclofenac  (ISO)
diethylstilbestrol  (EXP,ISO)
dimethylarsinous acid  (EXP)
dioxygen  (EXP)
dobutamine  (ISO)
dorsomorphin  (EXP)
doxorubicin  (EXP,ISO)
elemental selenium  (EXP)
enalapril  (ISO)
Enterolactone  (EXP)
entinostat  (EXP)
ethanol  (EXP,ISO)
fenvalerate  (ISO)
flutamide  (ISO)
folic acid  (ISO)
formaldehyde  (EXP)
fulvestrant  (EXP,ISO)
fumonisin B1  (ISO)
furan  (ISO)
gamma-hexachlorocyclohexane  (ISO)
gemcitabine  (EXP)
genistein  (ISO)
gentamycin  (ISO)
glutathione  (ISO)
graphite  (ISO)
Hexachloro-1,3-butadiene  (ISO)
hydrogen peroxide  (EXP)
ibuprofen  (EXP)
isocyanuric acid  (ISO)
isoflavones  (ISO)
isoprenaline  (ISO)
ketamine  (ISO)
ketoconazole  (ISO)
kojic acid  (ISO)
L-ascorbic acid  (ISO)
lead(0)  (EXP)
lead(2+)  (EXP)
levamisole  (EXP)
linsidomine  (ISO)
lipopolysaccharide  (ISO)
m-xylene  (ISO)
maneb  (ISO)
Meclizine  (EXP)
megestrol  (EXP)
melamine  (ISO)
mercury dichloride  (ISO)
metaproterenol  (ISO)
Methazolamide  (EXP)
methoxyacetic acid  (ISO)
methoxychlor  (ISO)
methylisothiazolinone  (EXP)
methylseleninic acid  (EXP)
mitoxantrone  (EXP)
N-(3-methyl-5-sulfamoyl-1,3,4-thiadiazol-2-ylidene)acetamide  (EXP)
N-methyl-N-nitrosourea  (ISO)
N-nitrosodiethylamine  (ISO)
naphthalene  (ISO)
Natamycin  (ISO)
nickel atom  (EXP,ISO)
nifedipine  (ISO)
nimodipine  (ISO)
nitroglycerin  (ISO)
Nonylphenol  (ISO)
nystatin  (ISO)
ochratoxin A  (ISO)
okadaic acid  (EXP)
olanzapine  (EXP)
omega-conotoxin GVIA  (ISO)
orciprenaline  (ISO)
oxaliplatin  (ISO)
ozone  (ISO)
p-chloromercuribenzoic acid  (EXP)
p-menthan-3-ol  (EXP)
p-tert-Amylphenol  (ISO)
paclitaxel  (EXP)
panobinostat  (EXP)
paracetamol  (EXP,ISO)
paraquat  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP)
phenethyl isothiocyanate  (EXP)
phenobarbital  (ISO)
phenylephrine  (ISO)
phenylmercury acetate  (EXP)
pirinixic acid  (ISO)
potassium bromate  (ISO)
potassium chromate  (EXP)
potassium dichromate  (EXP)
pregnenolone 16alpha-carbonitrile  (ISO)
procymidone  (ISO)
progesterone  (ISO)
rac-lactic acid  (EXP)
raloxifene  (EXP,ISO)
razoxane  (ISO)
resveratrol  (EXP,ISO)
rofecoxib  (EXP)
rotenone  (ISO)
sarin  (EXP)
SB 431542  (EXP)
selenium atom  (EXP)
silicon dioxide  (EXP)
silver atom  (EXP,ISO)
silver(0)  (EXP,ISO)
sodium arsenite  (EXP)
sodium fluoride  (ISO)
streptozocin  (ISO)
styrene  (ISO)
succimer  (ISO)
sulfasalazine  (ISO)
sulforaphane  (ISO)
sulindac  (EXP)
sunitinib  (EXP)
T-2 toxin  (EXP)
tacrolimus hydrate  (ISO)
tamoxifen  (ISO)
Tanshinone I  (EXP)
tert-butyl hydroperoxide  (EXP)
testosterone  (ISO)
Testosterone propionate  (ISO)
tetrachloromethane  (ISO)
tetracycline  (ISO)
tetramethylpyrazine  (ISO)
theophylline  (ISO)
thimerosal  (EXP)
titanium dioxide  (EXP,ISO)
topotecan  (ISO)
triazines  (ISO)
trichostatin A  (EXP)
Triptolide  (ISO)
tris(2-butoxyethyl) phosphate  (EXP)
troglitazone  (ISO)
valproic acid  (EXP)
vanadium atom  (EXP)
vanadium(0)  (EXP)
vancomycin  (ISO)
verapamil  (EXP)
vinclozolin  (ISO)
vitamin E  (EXP,ISO)
wortmannin  (ISO)
zinc atom  (EXP,ISO)
zinc(0)  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
aging  (ISO)
antimicrobial humoral response  (TAS)
cell morphogenesis  (IDA)
cellular response to growth factor stimulus  (ISO)
central nervous system myelin maintenance  (IMP)
chaperone-mediated protein complex assembly  (IDA)
chaperone-mediated protein folding  (IDA)
complement activation  (TAS)
complement activation, classical pathway  (IEA)
endocrine pancreas development  (ISO)
estrous cycle  (ISO)
immune complex clearance  (ISS)
innate immune response  (IEA)
intrinsic apoptotic signaling pathway  (IDA)
lipid metabolic process  (NAS)
microglial cell activation  (IDA)
microglial cell proliferation  (IDA)
negative regulation of amyloid fibril formation  (IDA,TAS)
negative regulation of amyloid-beta formation  (IDA)
negative regulation of apoptotic process  (ISO)
negative regulation of cell death  (IMP,TAS)
negative regulation of cellular response to thapsigargin  (IMP)
negative regulation of cellular response to tunicamycin  (IMP)
negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage  (IMP)
negative regulation of protein-containing complex assembly  (IDA,IMP)
negative regulation of release of cytochrome c from mitochondria  (TAS)
negative regulation of response to endoplasmic reticulum stress  (IMP)
neuron projection morphogenesis  (ISO)
platelet degranulation  (TAS)
positive regulation of amyloid fibril formation  (TAS)
positive regulation of amyloid-beta formation  (ISS)
positive regulation of apoptotic process  (IMP,ISS)
positive regulation of cell differentiation  (ISO)
positive regulation of cell population proliferation  (ISO)
positive regulation of gene expression  (ISS)
positive regulation of intrinsic apoptotic signaling pathway  (IMP)
positive regulation of neurofibrillary tangle assembly  (IMP)
positive regulation of neuron death  (IDA,IMP,ISS)
positive regulation of NF-kappaB transcription factor activity  (IMP)
positive regulation of nitric oxide biosynthetic process  (IDA)
positive regulation of proteasomal ubiquitin-dependent protein catabolic process  (IBA,IMP)
positive regulation of protein-containing complex assembly  (IDA)
positive regulation of receptor-mediated endocytosis  (IGI,ISS)
positive regulation of tau-protein kinase activity  (IMP)
positive regulation of tumor necrosis factor production  (IDA)
positive regulation of ubiquitin-dependent protein catabolic process  (IMP)
protein import  (IDA)
protein stabilization  (IDA)
protein targeting to lysosome involved in chaperone-mediated autophagy  (IDA)
regulation of amyloid-beta clearance  (IDA)
regulation of apoptotic process  (IBA)
regulation of cell population proliferation  (IMP)
regulation of complement activation  (TAS)
regulation of neuron death  (IDA,IMP)
regulation of neuronal signal transduction  (IMP)
release of cytochrome c from mitochondria  (IC)
response to light stimulus  (ISO)
response to misfolded protein  (IDA)
response to potassium ion  (ISO)
response to virus  (IEP)
response to wounding  (ISO)
reverse cholesterol transport  (TAS)

Phenotype Annotations     Click to see Annotation Detail View

Human Phenotype
References

References - curated
1. Burdon KP, etal., Mol Vis. 2008 Sep 22;14:1727-36.
2. Carlson ES, etal., Brain Res. 2008 Aug 7.
3. Chen M, etal., Gynecol Obstet Invest. 2005;60(3):133-8. Epub 2005 May 27.
4. Chesnokova V, etal., Mol Endocrinol. 2012 Dec;26(12):2092-103. doi: 10.1210/me.2012-1158. Epub 2012 Oct 9.
5. Ferrer I, etal., Brain Pathol. 2005 Apr;15(2):101-8.
6. Fink TM, etal., Genomics 1993 May;16(2):526-8.
7. Flanagan L, etal., BMC Cancer. 2010 Mar 22;10:107. doi: 10.1186/1471-2407-10-107.
8. Franquesa M, etal., Stem Cells Dev. 2012 Nov 20;21(17):3125-35. doi: 10.1089/scd.2012.0096. Epub 2012 May 18.
9. Garcia-Rodriguez S, etal., Actas Dermosifiliogr. 2013 Jul-Aug;104(6):497-503. doi: 10.1016/j.ad.2012.11.019. Epub 2013 Mar 21.
10. Giannakopoulos P, etal., Acta Neuropathol. 1998 Apr;95(4):387-94.
11. GOA_HUMAN data from the GO Consortium
12. Gwon JS, etal., Glia. 2004 Jul;47(1):35-45.
13. Hernandez C, etal., Diabetes Metab Res Rev. 2013 Sep;29(6):499-506. doi: 10.1002/dmrr.2419.
14. Jung GS, etal., J Am Soc Nephrol. 2012 Jan;23(1):73-85. doi: 10.1681/ASN.2011010048. Epub 2011 Nov 3.
15. Jurkunas UV, etal., Invest Ophthalmol Vis Sci. 2008 Jul;49(7):2946-55. doi: 10.1167/iovs.07-1405. Epub 2008 Mar 31.
16. Kalka K, etal., Cancer Res. 2000 Nov 1;60(21):5984-7.
17. Kaya-Dagistanli F and Ozturk M, Acta Histochem. 2013 Jul;115(6):577-86. doi: 10.1016/j.acthis.2012.12.007. Epub 2013 Jan 23.
18. Kim HJ, etal., Arterioscler Thromb Vasc Biol. 2009 Oct;29(10):1558-64. doi: 10.1161/ATVBAHA.109.190058. Epub 2009 Aug 20.
19. Kim J, etal., Endocrinology. 2009 Aug;150(8):3576-83. doi: 10.1210/en.2008-1782. Epub 2009 May 14.
20. Kim JH, etal., Invest Ophthalmol Vis Sci. 2010 Mar;51(3):1659-65. doi: 10.1167/iovs.09-3615. Epub 2009 Oct 29.
21. Kim YS, etal., Brain Res. 2003 Jun 20;976(1):53-9.
22. Kruger S, etal., Neoplasma. 2007;54(1):46-50.
23. Krumbiegel M, etal., Invest Ophthalmol Vis Sci. 2009 Jun;50(6):2796-801. doi: 10.1167/iovs.08-2339. Epub 2009 Jan 31.
24. Li J, etal., J Int Med Res. 2012;40(2):545-55.
25. Liu X, etal., Acta Physiol (Oxf). 2014 Jul 29. doi: 10.1111/apha.12352.
26. Matthaei M, etal., Invest Ophthalmol Vis Sci. 2012 Sep 28;53(10):6718-27.
27. Moll S, etal., Am J Pathol. 1998 Apr;152(4):953-62.
28. Nakamura T, etal., Invest Ophthalmol Vis Sci. 2002 Jun;43(6):1702-7.
29. Nakamura T, Nippon Ganka Gakkai Zasshi. 2004 Nov;108(11):654-64.
30. Navab M, etal., Arterioscler Thromb Vasc Biol. 2005 Sep;25(9):1932-7. Epub 2005 Jun 16.
31. Newkirk MM, etal., J Rheumatol. 1999 Mar;26(3):597-603.
32. Nishida K, etal., Br J Ophthalmol. 1999 Oct;83(10):1178-82.
33. Niu Z, etal., Acta Biochim Biophys Sin (Shanghai). 2012 Dec;44(12):991-8. doi: 10.1093/abbs/gms091. Epub 2012 Oct 25.
34. Ohlsson M, etal., J Neurotrauma. 2003 Sep;20(9):895-904.
35. Ou-Yang MC, etal., ScientificWorldJournal. 2013 Jul 15;2013:382523. doi: 10.1155/2013/382523. eCollection 2013.
36. Padhy B, etal., Exp Eye Res. 2014 Jul 21;127C:69-76. doi: 10.1016/j.exer.2014.07.005.
37. Park CH, etal., Curr Eye Res. 2007 Dec;32(12):1055-63.
38. Redondo M, etal., Am J Pathol. 2000 Aug;157(2):393-9.
39. RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
40. RGD automated import pipeline for gene-chemical interactions
41. Shi H, etal., Breast Cancer Res Treat. 2012 Feb;131(3):1039-47. doi: 10.1007/s10549-011-1826-2. Epub 2011 Oct 26.
42. Shirasawa T, etal., J Atheroscler Thromb. 2009;16(6):772-81. Epub 2009 Dec 22.
43. Smith SB, etal., Invest Ophthalmol Vis Sci. 1995 Oct;36(11):2193-201.
44. Suzuki S, etal., Cancer Sci. 2013 Dec;104(12):1711-7. doi: 10.1111/cas.12292. Epub 2013 Oct 28.
45. Takase O, etal., Clin Exp Nephrol. 2008 Jun;12(3):181-8. doi: 10.1007/s10157-008-0038-5. Epub 2008 Feb 15.
46. Thomas-Tikhonenko A, etal., Cancer Res. 2004 May 1;64(9):3126-36.
47. Tobisawa S, etal., J Dermatol Sci. 2013 Sep;71(3):160-6. doi: 10.1016/j.jdermsci.2013.04.020. Epub 2013 May 2.
48. Togashi Y, etal., Exp Toxicol Pathol. 2013 Nov;65(7-8):1137-43. doi: 10.1016/j.etp.2013.05.005. Epub 2013 Jun 21.
49. Tripodi D, etal., BMC Med Genomics. 2009 Nov 10;2:65. doi: 10.1186/1755-8794-2-65.
50. Tuncdemir M and Ozturk M, J Mol Histol. 2008 Dec;39(6):605-16. doi: 10.1007/s10735-008-9201-2. Epub 2008 Oct 24.
51. Van Dijk A, etal., Eur J Clin Invest. 2010 Oct;40(10):893-902. doi: 10.1111/j.1365-2362.2010.02345.x.
52. Vinken P, etal., Toxicol Pathol. 2012 Oct;40(7):1049-62. Epub 2012 May 11.
53. Wiggins AK, etal., Brain Res Mol Brain Res 2003 May 26;114(1):20-30.
54. Yanaba K, etal., Arch Dermatol Res. 2012 Aug;304(6):459-63. doi: 10.1007/s00403-012-1219-3. Epub 2012 Feb 17.
55. Yu HR, etal., Pediatr Cardiol. 2010 Nov;31(8):1151-6. doi: 10.1007/s00246-010-9769-7. Epub 2010 Aug 15.
56. Zenkel M, etal., Invest Ophthalmol Vis Sci. 2006 May;47(5):1982-90.
57. Zhang Q, etal., Biomark Med. 2014 Jan;8(1):85-94. doi: 10.2217/bmm.13.106.
Additional References at PubMed
PMID:1424805   PMID:1491011   PMID:1551440   PMID:1585460   PMID:1903064   PMID:1924317   PMID:1974459   PMID:2185274   PMID:2387851   PMID:2454950   PMID:2601725   PMID:2721499  
PMID:2780565   PMID:2780570   PMID:3154963   PMID:3167096   PMID:7615015   PMID:7626703   PMID:7768901   PMID:7802646   PMID:8181474   PMID:8292612   PMID:8328966   PMID:8345200  
PMID:8387101   PMID:8555189   PMID:8634259   PMID:8752142   PMID:8759347   PMID:8843912   PMID:8889548   PMID:9228033   PMID:9336835   PMID:9537999   PMID:10066740   PMID:10219089  
PMID:10329371   PMID:10694874   PMID:11123922   PMID:11186422   PMID:11570883   PMID:11714447   PMID:11795992   PMID:11813210   PMID:11892985   PMID:11904161   PMID:11906815   PMID:12047389  
PMID:12082621   PMID:12172907   PMID:12176985   PMID:12200037   PMID:12393179   PMID:12427144   PMID:12429802   PMID:12470829   PMID:12477932   PMID:12551933   PMID:12679903   PMID:12754519  
PMID:12824284   PMID:12860995   PMID:12867999   PMID:12882985   PMID:14618611   PMID:14630798   PMID:14702039   PMID:14718574   PMID:14760718   PMID:15033782   PMID:15133840   PMID:15146195  
PMID:15158456   PMID:15174051   PMID:15247015   PMID:15252304   PMID:15304052   PMID:15342556   PMID:15389725   PMID:15480429   PMID:15489334   PMID:15492264   PMID:15499376   PMID:15538973  
PMID:15591223   PMID:15649646   PMID:15689620   PMID:15791650   PMID:15809754   PMID:15857407   PMID:15883054   PMID:15897157   PMID:15929184   PMID:15955107   PMID:16113678   PMID:16179938  
PMID:16263699   PMID:16331665   PMID:16335952   PMID:16421571   PMID:16464517   PMID:16490286   PMID:16502470   PMID:16548883   PMID:16675913   PMID:16682745   PMID:16709604   PMID:16709934  
PMID:16740002   PMID:16775601   PMID:16806233   PMID:16955214   PMID:17043677   PMID:17048076   PMID:17056579   PMID:17080454   PMID:17148459   PMID:17170699   PMID:17224269   PMID:17260971  
PMID:17322305   PMID:17407782   PMID:17412999   PMID:17420006   PMID:17451556   PMID:17512083   PMID:17534116   PMID:17535098   PMID:17567961   PMID:17689225   PMID:17855704   PMID:17872975  
PMID:17974975   PMID:18079682   PMID:18082619   PMID:18097679   PMID:18239862   PMID:18458059   PMID:18514801   PMID:18542050   PMID:18612545   PMID:18624398   PMID:18649357   PMID:18709641  
PMID:18712185   PMID:18714397   PMID:18786636   PMID:18813793   PMID:18842294   PMID:19056867   PMID:19118032   PMID:19137541   PMID:19165232   PMID:19166932   PMID:19177010   PMID:19199708  
PMID:19220628   PMID:19264665   PMID:19289586   PMID:19344414   PMID:19353783   PMID:19357365   PMID:19391138   PMID:19413638   PMID:19446882   PMID:19535339   PMID:19542874   PMID:19651157  
PMID:19664600   PMID:19734902   PMID:19734903   PMID:19757199   PMID:19793084   PMID:19814590   PMID:19878569   PMID:19878770   PMID:19878774   PMID:19879420   PMID:19879421   PMID:19879422  
PMID:19879423   PMID:19903745   PMID:19935703   PMID:19940549   PMID:19996109   PMID:20000738   PMID:20005821   PMID:20007348   PMID:20009887   PMID:20019877   PMID:20028970   PMID:20057494  
PMID:20058210   PMID:20068069   PMID:20096688   PMID:20195357   PMID:20209083   PMID:20353268   PMID:20360068   PMID:20410100   PMID:20460622   PMID:20497247   PMID:20534741   PMID:20551380  
PMID:20554627   PMID:20570404   PMID:20599866   PMID:20603455   PMID:20614220   PMID:20674675   PMID:20697030   PMID:20738160   PMID:20739100   PMID:20842452   PMID:20847305   PMID:20850846  
PMID:20855565   PMID:20873220   PMID:20930273   PMID:21042904   PMID:21043527   PMID:21059989   PMID:21135756   PMID:21163940   PMID:21224044   PMID:21240462   PMID:21242307   PMID:21280673  
PMID:21300948   PMID:21347408   PMID:21349332   PMID:21379329   PMID:21397462   PMID:21420681   PMID:21422520   PMID:21447104   PMID:21460841   PMID:21460853   PMID:21467232   PMID:21467285  
PMID:21505792   PMID:21508640   PMID:21525168   PMID:21527247   PMID:21543606   PMID:21567405   PMID:21573492   PMID:21627779   PMID:21630085   PMID:21633299   PMID:21732348   PMID:21761117  
PMID:21803450   PMID:21824521   PMID:21873635   PMID:21892414   PMID:21899841   PMID:21900379   PMID:21912625   PMID:21953030   PMID:21953454   PMID:21980627   PMID:21987172   PMID:21988832  
PMID:21998749   PMID:22012253   PMID:22013110   PMID:22015308   PMID:22016805   PMID:22068036   PMID:22082661   PMID:22122982   PMID:22130675   PMID:22145905   PMID:22159129   PMID:22166956  
PMID:22179788   PMID:22232000   PMID:22234156   PMID:22236192   PMID:22248099   PMID:22258514   PMID:22266332   PMID:22268729   PMID:22274961   PMID:22296908   PMID:22391565   PMID:22402018  
PMID:22465014   PMID:22506010   PMID:22516433   PMID:22528093   PMID:22532874   PMID:22539578   PMID:22545109   PMID:22569264   PMID:22617144   PMID:22647452   PMID:22689054   PMID:22701550  
PMID:22795969   PMID:22810586   PMID:22863883   PMID:22889670   PMID:22896337   PMID:22898364   PMID:22902018   PMID:22906254   PMID:22949882   PMID:22952074   PMID:22975582   PMID:22981431  
PMID:22990118   PMID:23010347   PMID:23106396   PMID:23164821   PMID:23174100   PMID:23201481   PMID:23208459   PMID:23209684   PMID:23276503   PMID:23279642   PMID:23376485   PMID:23411014  
PMID:23416242   PMID:23457489   PMID:23521156   PMID:23533145   PMID:23538443   PMID:23573206   PMID:23589125   PMID:23602568   PMID:23621580   PMID:23643458   PMID:23650005   PMID:23658023  
PMID:23673647   PMID:23769013   PMID:23770713   PMID:23786771   PMID:23805218   PMID:23816822   PMID:23892938   PMID:23896217   PMID:24008723   PMID:24073260   PMID:24085287   PMID:24117116  
PMID:24162737   PMID:24217652   PMID:24244428   PMID:24327270   PMID:24334140   PMID:24378367   PMID:24388797   PMID:24407433   PMID:24428970   PMID:24446231   PMID:24477687   PMID:24491388  
PMID:24578178   PMID:24599003   PMID:24660791   PMID:24696417   PMID:24743338   PMID:24758255   PMID:24797263   PMID:24806679   PMID:24937130   PMID:24947876   PMID:24958191   PMID:24967550  
PMID:24996046   PMID:25051234   PMID:25056061   PMID:25071085   PMID:25076422   PMID:25083615   PMID:25343293   PMID:25402950   PMID:25451228   PMID:25464035   PMID:25478940   PMID:25496871  
PMID:25503391   PMID:25574066   PMID:25600802   PMID:25609201   PMID:25633098   PMID:25703218   PMID:25849827   PMID:25855029   PMID:25884309   PMID:25884382   PMID:25917404   PMID:25934174  
PMID:25940137   PMID:25963833   PMID:26062444   PMID:26081122   PMID:26159041   PMID:26167880   PMID:26179372   PMID:26186194   PMID:26264614   PMID:26293319   PMID:26343804   PMID:26352072  
PMID:26368530   PMID:26399194   PMID:26434199   PMID:26449541   PMID:26482819   PMID:26488311   PMID:26496610   PMID:26545630   PMID:26661731   PMID:26673020   PMID:26683597   PMID:26716898  
PMID:26738351   PMID:26757186   PMID:26781643   PMID:26795031   PMID:26810527   PMID:26826245   PMID:26884339   PMID:26899953   PMID:26939938   PMID:26988917   PMID:27017968   PMID:27068509  
PMID:27070750   PMID:27071964   PMID:27076484   PMID:27079858   PMID:27143425   PMID:27148688   PMID:27197790   PMID:27221710   PMID:27229352   PMID:27233433   PMID:27248362   PMID:27365216  
PMID:27378688   PMID:27396407   PMID:27477018   PMID:27543695   PMID:27559042   PMID:27576135   PMID:27684187   PMID:27773727   PMID:27781389   PMID:27806672   PMID:27928700   PMID:27983983  
PMID:28064403   PMID:28120874   PMID:28168383   PMID:28233427   PMID:28391884   PMID:28411179   PMID:28428074   PMID:28514442   PMID:28558900   PMID:28631188   PMID:28803177   PMID:28843803  
PMID:28849249   PMID:28887769   PMID:28887822   PMID:28890185   PMID:28902428   PMID:28954633   PMID:28958138   PMID:28972394   PMID:28973302   PMID:28986164   PMID:29133960   PMID:29169407  
PMID:29200898   PMID:29253572   PMID:29279586   PMID:29324756   PMID:29396813   PMID:29400663   PMID:29436591   PMID:29463595   PMID:29504051   PMID:29507755   PMID:29509190   PMID:29509794  
PMID:29511261   PMID:29511890   PMID:29628342   PMID:29665645   PMID:29717106   PMID:29970704   PMID:30002194   PMID:30038359   PMID:30053814   PMID:30097533   PMID:30465328   PMID:30560405  
PMID:30565691   PMID:30659075   PMID:30659732   PMID:30669930   PMID:30691533   PMID:30833792   PMID:30952532   PMID:30967152   PMID:31029938   PMID:31077261   PMID:31180492   PMID:31270237  
PMID:31273033   PMID:31343316   PMID:31343317   PMID:31406108   PMID:31413325   PMID:31489966   PMID:31586073   PMID:31614179   PMID:31739636   PMID:31753913   PMID:31833103   PMID:32062451  
PMID:32332780   PMID:32457219   PMID:32516132   PMID:32764517   PMID:32814053   PMID:32913257   PMID:32991610   PMID:32992916   PMID:33003328   PMID:33060605   PMID:33141553   PMID:33152068  
PMID:33160989   PMID:33184463  


Genomics

Comparative Map Data
CLU
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl827,596,917 - 27,614,700 (-)EnsemblGRCh38hg38GRCh38
GRCh38827,596,917 - 27,614,700 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37827,454,434 - 27,472,217 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36827,510,368 - 27,528,244 (-)NCBINCBI36hg18NCBI36
Build 34827,510,367 - 27,524,855NCBI
Celera826,414,541 - 26,432,416 (-)NCBI
Cytogenetic Map8p21.1NCBI
HuRef825,999,468 - 26,017,387 (-)NCBIHuRef
CHM1_1827,656,307 - 27,674,217 (-)NCBICHM1_1
Clu
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391466,205,932 - 66,218,997 (+)NCBIGRCm39mm39
GRCm39 Ensembl1466,205,932 - 66,218,996 (+)Ensembl
GRCm381465,968,483 - 65,981,548 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1465,968,483 - 65,981,547 (+)EnsemblGRCm38mm10GRCm38
MGSCv371466,587,320 - 66,600,382 (+)NCBIGRCm37mm9NCBIm37
MGSCv361464,922,735 - 64,935,658 (+)NCBImm8
Celera1451,264,543 - 51,272,775 (-)NCBICelera
Cytogenetic Map14D1NCBI
cM Map1434.36NCBI
Clu
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21540,161,068 - 40,200,315 (+)NCBI
Rnor_6.0 Ensembl1542,640,146 - 42,665,857 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01542,626,612 - 42,665,858 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01548,926,511 - 48,965,757 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41545,365,779 - 45,405,314 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11545,381,558 - 45,421,094 (+)NCBI
Celera1539,832,711 - 39,871,901 (+)NCBICelera
Cytogenetic Map15p12NCBI
Clu
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540350,160,598 - 50,175,876 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540350,160,598 - 50,175,876 (-)NCBIChiLan1.0ChiLan1.0
CLU
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1824,070,053 - 24,086,934 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl824,070,053 - 24,083,523 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0826,867,973 - 26,884,838 (-)NCBIMhudiblu_PPA_v0panPan3
CLU
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12529,982,811 - 29,999,565 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2529,982,811 - 29,999,563 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2530,569,577 - 30,586,344 (+)NCBI
ROS_Cfam_1.02530,173,217 - 30,190,014 (+)NCBI
UMICH_Zoey_3.12530,103,442 - 30,120,185 (+)NCBI
UNSW_CanFamBas_1.02529,984,486 - 30,001,273 (+)NCBI
UU_Cfam_GSD_1.02530,150,889 - 30,167,668 (+)NCBI
Clu
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244049438,072,565 - 8,086,406 (+)NCBI
SpeTri2.0NW_004936675499,745 - 513,515 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CLU
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1411,336,590 - 11,352,475 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11411,336,585 - 11,352,569 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21412,516,644 - 12,527,851 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CLU
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1825,704,441 - 25,721,789 (-)NCBI
ChlSab1.1 Ensembl825,703,257 - 25,721,789 (-)Ensembl
Vero_WHO_p1.0NW_02366605216,420,009 - 16,437,520 (+)NCBI
Clu
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462475822,431,331 - 22,444,185 (-)NCBI

Position Markers
RH27907  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37827,455,543 - 27,455,673UniSTSGRCh37
Build 36827,511,460 - 27,511,590RGDNCBI36
Celera826,415,633 - 26,415,763RGD
Cytogenetic Map8p21-p12UniSTS
HuRef826,000,577 - 26,000,707UniSTS
PMC310777P3  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37827,455,614 - 27,456,150UniSTSGRCh37
Build 36827,511,531 - 27,512,067RGDNCBI36
Celera826,415,704 - 26,416,240RGD
Cytogenetic Map8p21-p12UniSTS
HuRef826,000,648 - 26,001,184UniSTS
RH11712  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37827,456,005 - 27,456,110UniSTSGRCh37
Build 36827,511,922 - 27,512,027RGDNCBI36
Celera826,416,095 - 26,416,200RGD
Cytogenetic Map8p21-p12UniSTS
HuRef826,001,039 - 26,001,144UniSTS
GeneMap99-GB4 RH Map8108.79UniSTS
NCBI RH Map8339.8UniSTS
STS-J02908  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37827,456,012 - 27,456,150UniSTSGRCh37
Build 36827,511,929 - 27,512,067RGDNCBI36
Celera826,416,102 - 26,416,240RGD
Cytogenetic Map8p21-p12UniSTS
HuRef826,001,046 - 26,001,184UniSTS
GeneMap99-GB4 RH Map8108.09UniSTS

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:6301
Count of miRNA genes:1166
Interacting mature miRNAs:1450
Transcripts:ENST00000316403, ENST00000405140, ENST00000518050, ENST00000519472, ENST00000519742, ENST00000520491, ENST00000520796, ENST00000521770, ENST00000522098, ENST00000522238, ENST00000522299, ENST00000522413, ENST00000522502, ENST00000523396, ENST00000523500, ENST00000523589, ENST00000546343, ENST00000560366, ENST00000560566
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component pharyngeal arch
High 59 993 668 183 7 174 714 34 1792 51 336 337 10 2 713
Medium 2301 1908 1046 439 1288 287 3187 1716 1913 355 1091 1189 161 1202 1695 2
Low 68 86 7 2 288 4 437 443 27 13 29 65 3 1 380 2 2
Below cutoff 5 3 3 263 15 2 2 2 19 1 1

Sequence

Nucleotide Sequences
RefSeq Transcripts NG_027845 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001831 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_038335 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_045494 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide A21577 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB839016 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF311103 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH003641 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK093399 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK301324 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK313870 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY172563 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY184486 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY341244 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY513288 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC010514 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC013221 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC019588 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC029972 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BF528374 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BG819541 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BG914262 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BM682289 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BM723283 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BP193735 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BQ181025 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BQ181739 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BX418836 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BX459023 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BX648414 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DN990822 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ004564 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ006268 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ012938 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EB385800 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  GQ891391 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HI179162 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HI179164 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  J02908 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L00974 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M25915 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M26639 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M64722 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M74816 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X14723 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000316403   ⟹   ENSP00000315130
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl827,596,917 - 27,614,700 (-)Ensembl
RefSeq Acc Id: ENST00000405140   ⟹   ENSP00000385419
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl827,597,808 - 27,611,431 (-)Ensembl
RefSeq Acc Id: ENST00000518050
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl827,608,541 - 27,614,700 (-)Ensembl
RefSeq Acc Id: ENST00000519472   ⟹   ENSP00000427868
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl827,608,937 - 27,614,681 (-)Ensembl
RefSeq Acc Id: ENST00000519742   ⟹   ENSP00000431026
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl827,606,354 - 27,611,966 (-)Ensembl
RefSeq Acc Id: ENST00000520491   ⟹   ENSP00000429881
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl827,606,364 - 27,611,218 (-)Ensembl
RefSeq Acc Id: ENST00000520796   ⟹   ENSP00000429336
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl827,605,141 - 27,611,205 (-)Ensembl
RefSeq Acc Id: ENST00000521770   ⟹   ENSP00000428033
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl827,598,143 - 27,600,015 (-)Ensembl
RefSeq Acc Id: ENST00000522098   ⟹   ENSP00000430821
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl827,598,537 - 27,605,339 (-)Ensembl
RefSeq Acc Id: ENST00000522238   ⟹   ENSP00000429087
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl827,610,476 - 27,614,243 (-)Ensembl
RefSeq Acc Id: ENST00000522299
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl827,597,996 - 27,614,693 (-)Ensembl
RefSeq Acc Id: ENST00000522413   ⟹   ENSP00000428779
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl827,606,382 - 27,614,692 (-)Ensembl
RefSeq Acc Id: ENST00000522502
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl827,604,218 - 27,605,339 (-)Ensembl
RefSeq Acc Id: ENST00000523396   ⟹   ENSP00000428526
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl827,608,937 - 27,614,698 (-)Ensembl
RefSeq Acc Id: ENST00000523500   ⟹   ENSP00000429620
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl827,597,996 - 27,611,357 (-)Ensembl
RefSeq Acc Id: ENST00000523589   ⟹   ENSP00000431070
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl827,604,310 - 27,614,690 (-)Ensembl
RefSeq Acc Id: ENST00000560566   ⟹   ENSP00000453247
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl827,604,366 - 27,611,751 (-)Ensembl
RefSeq Acc Id: NM_001831   ⟹   NP_001822
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38827,596,917 - 27,614,700 (-)NCBI
Build 36827,510,368 - 27,528,244 (-)NCBI Archive
HuRef825,999,468 - 26,017,387 (-)NCBI
CHM1_1827,656,307 - 27,674,217 (-)NCBI
Sequence:
RefSeq Acc Id: NR_038335
RefSeq Status: REVIEWED
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38827,596,917 - 27,611,371 (-)NCBI
GRCh37827,454,434 - 27,472,328 (-)ENTREZGENE
HuRef825,999,468 - 26,017,387 (-)ENTREZGENE
CHM1_1827,656,307 - 27,670,835 (-)NCBI
Sequence:
RefSeq Acc Id: NR_045494
RefSeq Status: REVIEWED
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38827,596,917 - 27,611,751 (-)NCBI
GRCh37827,454,434 - 27,472,328 (-)NCBI
HuRef825,999,468 - 26,017,387 (-)NCBI
CHM1_1827,656,307 - 27,671,149 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_001822   ⟸   NM_001831
- Peptide Label: preproprotein
- UniProtKB: P10909 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSP00000427868   ⟸   ENST00000519472
RefSeq Acc Id: ENSP00000431026   ⟸   ENST00000519742
RefSeq Acc Id: ENSP00000429881   ⟸   ENST00000520491
RefSeq Acc Id: ENSP00000429336   ⟸   ENST00000520796
RefSeq Acc Id: ENSP00000453247   ⟸   ENST00000560566
RefSeq Acc Id: ENSP00000428033   ⟸   ENST00000521770
RefSeq Acc Id: ENSP00000429087   ⟸   ENST00000522238
RefSeq Acc Id: ENSP00000430821   ⟸   ENST00000522098
RefSeq Acc Id: ENSP00000428779   ⟸   ENST00000522413
RefSeq Acc Id: ENSP00000385419   ⟸   ENST00000405140
RefSeq Acc Id: ENSP00000429620   ⟸   ENST00000523500
RefSeq Acc Id: ENSP00000431070   ⟸   ENST00000523589
RefSeq Acc Id: ENSP00000428526   ⟸   ENST00000523396
RefSeq Acc Id: ENSP00000315130   ⟸   ENST00000316403
Protein Domains
CLa   CLb

Promoters
RGD ID:6806474
Promoter ID:HG_KWN:60998
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:HeLa_S3
Transcripts:UC003XFW.1,   UC010LUX.1
Position:
Human AssemblyChrPosition (strand)Source
Build 36827,523,726 - 27,524,226 (-)MPROMDB
RGD ID:6806570
Promoter ID:HG_KWN:60999
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:HeLa_S3
Transcripts:ENST00000405140,   NM_203339,   UC003XFY.1
Position:
Human AssemblyChrPosition (strand)Source
Build 36827,524,626 - 27,525,527 (-)MPROMDB
RGD ID:6806646
Promoter ID:HG_KWN:61000
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   HeLa_S3,   Lymphoblastoid,   NB4
Transcripts:ENST00000316403,   OTTHUMT00000219953
Position:
Human AssemblyChrPosition (strand)Source
Build 36827,527,751 - 27,528,251 (-)MPROMDB
RGD ID:6850782
Promoter ID:EP73185
Type:single initiation site
Name:HS_CLU
Description:Clusterin (complement lysis inhibitor, SP-40,40, sulfatedglycoprotein 2, testosterone-repressed prostate message 2,apolipoprotein J).
SO ACC ID:SO:0000170
Source:EPD (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:NEDO full length human cDNA sequencing project.; Oligo-capping
Position:
Human AssemblyChrPosition (strand)Source
Build 36827,528,136 - 27,528,196EPD
RGD ID:7212957
Promoter ID:EPDNEW_H12224
Type:initiation region
Name:CLU_1
Description:clusterin
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh38827,614,700 - 27,614,760EPDNEW

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 8p23.1-11.21(chr8:12609975-42085703)x3 copy number gain See cases [RCV000050294] Chr8:12609975..42085703 [GRCh38]
Chr8:12467484..41943221 [GRCh37]
Chr8:12511855..42062378 [NCBI36]
Chr8:8p23.1-11.21
pathogenic
GRCh38/hg38 8p21.2-q11.21(chr8:25832130-48521849)x3 copy number gain See cases [RCV000050904] Chr8:25832130..48521849 [GRCh38]
Chr8:25689646..49434409 [GRCh37]
Chr8:25745563..49596962 [NCBI36]
Chr8:8p21.2-q11.21
pathogenic
GRCh38/hg38 8p23.1-11.1(chr8:12728904-43673207)x3 copy number gain See cases [RCV000050912] Chr8:12728904..43673207 [GRCh38]
Chr8:12586413..43528350 [GRCh37]
Chr8:12630784..43647507 [NCBI36]
Chr8:8p23.1-11.1
pathogenic
GRCh38/hg38 8p23.1-12(chr8:12383584-36370018)x3 copy number gain See cases [RCV000051145] Chr8:12383584..36370018 [GRCh38]
Chr8:12241093..36227536 [GRCh37]
Chr8:12285464..36347088 [NCBI36]
Chr8:8p23.1-12
pathogenic
GRCh38/hg38 8p23.3-q24.3(chr8:241530-145049449)x3 copy number gain See cases [RCV000051206] Chr8:241530..145049449 [GRCh38]
Chr8:191530..146274835 [GRCh37]
Chr8:181530..146245639 [NCBI36]
Chr8:8p23.3-q24.3
pathogenic
GRCh38/hg38 8p23.1-11.21(chr8:12728904-41928741)x3 copy number gain See cases [RCV000051110] Chr8:12728904..41928741 [GRCh38]
Chr8:12586413..41786259 [GRCh37]
Chr8:12630784..41905416 [NCBI36]
Chr8:8p23.1-11.21
pathogenic
GRCh38/hg38 8p23.1-11.1(chr8:12609975-43336172)x3 copy number gain See cases [RCV000053630] Chr8:12609975..43336172 [GRCh38]
Chr8:12467484..43191315 [GRCh37]
Chr8:12511855..43310472 [NCBI36]
Chr8:8p23.1-11.1
pathogenic
GRCh38/hg38 8p23.1-11.1(chr8:12609975-43255410)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053631]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053631]|See cases [RCV000053631] Chr8:12609975..43255410 [GRCh38]
Chr8:12467484..43110553 [GRCh37]
Chr8:12511855..43229710 [NCBI36]
Chr8:8p23.1-11.1
pathogenic
GRCh38/hg38 8p23.1-11.1(chr8:12750796-43532444)x3 copy number gain See cases [RCV000053632] Chr8:12750796..43532444 [GRCh38]
Chr8:12608305..43387587 [GRCh37]
Chr8:12652676..43506744 [NCBI36]
Chr8:8p23.1-11.1
pathogenic
GRCh38/hg38 8p23.1-12(chr8:12750796-29445409)x3 copy number gain See cases [RCV000053633] Chr8:12750796..29445409 [GRCh38]
Chr8:12608305..29302926 [GRCh37]
Chr8:12652676..29358845 [NCBI36]
Chr8:8p23.1-12
pathogenic
GRCh38/hg38 8p22-q11.21(chr8:14940110-47929925)x3 copy number gain See cases [RCV000053635] Chr8:14940110..47929925 [GRCh38]
Chr8:14797619..48842485 [GRCh37]
Chr8:14841990..49005038 [NCBI36]
Chr8:8p22-q11.21
pathogenic
GRCh38/hg38 8p23.1-11.23(chr8:12609975-37892000)x3 copy number gain See cases [RCV000053629] Chr8:12609975..37892000 [GRCh38]
Chr8:12467484..37749518 [GRCh37]
Chr8:12511855..37868676 [NCBI36]
Chr8:8p23.1-11.23
pathogenic
GRCh38/hg38 8p23.3-q24.3(chr8:241530-145054634)x3 copy number gain See cases [RCV000053602] Chr8:241530..145054634 [GRCh38]
Chr8:191530..146280020 [GRCh37]
Chr8:181530..146250824 [NCBI36]
Chr8:8p23.3-q24.3
pathogenic
GRCh38/hg38 8p23.3-q24.3(chr8:244417-145054775)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053604]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053604]|See cases [RCV000053604] Chr8:244417..145054775 [GRCh38]
Chr8:194417..146280161 [GRCh37]
Chr8:184417..146250965 [NCBI36]
Chr8:8p23.3-q24.3
pathogenic
GRCh38/hg38 8p23.3-12(chr8:96310-30614703)x3 copy number gain See cases [RCV000053599] Chr8:96310..30614703 [GRCh38]
Chr8:46310..30472220 [GRCh37]
Chr8:36310..30591762 [NCBI36]
Chr8:8p23.3-12
pathogenic
GRCh38/hg38 8p21.2-12(chr8:24910364-31210737)x1 copy number loss See cases [RCV000054237] Chr8:24910364..31210737 [GRCh38]
Chr8:24767877..31068253 [GRCh37]
Chr8:24823781..31187795 [NCBI36]
Chr8:8p21.2-12
pathogenic
NM_001831.3(CLU):c.1017G>A (p.Arg339=) single nucleotide variant Malignant melanoma [RCV000068271] Chr8:27599927 [GRCh38]
Chr8:27457444 [GRCh37]
Chr8:27513361 [NCBI36]
Chr8:8p21.1
not provided
GRCh37/hg19 8p23.3-11.1(chr8:176814-43396776) copy number gain Abnormality of the fetal cardiovascular system [RCV001291977] Chr8:176814..43396776 [GRCh37]
Chr8:8p23.3-11.1
pathogenic
GRCh38/hg38 8p23.1-11.1(chr8:12609975-43673207)x3 copy number gain See cases [RCV000135786] Chr8:12609975..43673207 [GRCh38]
Chr8:12467484..43528350 [GRCh37]
Chr8:12511855..43647507 [NCBI36]
Chr8:8p23.1-11.1
pathogenic
GRCh38/hg38 8p23.1-11.1(chr8:12383584-43673207)x3 copy number gain See cases [RCV000135566] Chr8:12383584..43673207 [GRCh38]
Chr8:12241093..43528350 [GRCh37]
Chr8:12285464..43647507 [NCBI36]
Chr8:8p23.1-11.1
pathogenic
GRCh38/hg38 8p23.1-11.21(chr8:12728904-40169194)x3 copy number gain See cases [RCV000136516] Chr8:12728904..40169194 [GRCh38]
Chr8:12586413..40026713 [GRCh37]
Chr8:12630784..40145870 [NCBI36]
Chr8:8p23.1-11.21
pathogenic
GRCh38/hg38 8p21.2-12(chr8:24910364-31196357)x1 copy number loss See cases [RCV000136120] Chr8:24910364..31196357 [GRCh38]
Chr8:24767877..31053873 [GRCh37]
Chr8:24823781..31173415 [NCBI36]
Chr8:8p21.2-12
pathogenic
GRCh38/hg38 8p23.1-12(chr8:12725750-30180521)x3 copy number gain See cases [RCV000136825] Chr8:12725750..30180521 [GRCh38]
Chr8:12583259..30038037 [GRCh37]
Chr8:12627630..30157579 [NCBI36]
Chr8:8p23.1-12
pathogenic
GRCh38/hg38 8p23.1-11.1(chr8:12182421-43673207)x3 copy number gain See cases [RCV000137249] Chr8:12182421..43673207 [GRCh38]
Chr8:12039930..43528350 [GRCh37]
Chr8:12077339..43647507 [NCBI36]
Chr8:8p23.1-11.1
pathogenic
GRCh38/hg38 8p23.1-12(chr8:12698495-35476082)x3 copy number gain See cases [RCV000138058] Chr8:12698495..35476082 [GRCh38]
Chr8:12556004..35333600 [GRCh37]
Chr8:12600375..35453142 [NCBI36]
Chr8:8p23.1-12
pathogenic
GRCh38/hg38 8p21.2-12(chr8:25171103-31750600)x1 copy number loss See cases [RCV000138081] Chr8:25171103..31750600 [GRCh38]
Chr8:25028618..31608116 [GRCh37]
Chr8:25084535..31727658 [NCBI36]
Chr8:8p21.2-12
pathogenic
GRCh38/hg38 8p23.3-11.23(chr8:226452-38021728)x3 copy number gain See cases [RCV000137807] Chr8:226452..38021728 [GRCh38]
Chr8:176452..37879246 [GRCh37]
Chr8:166452..37998403 [NCBI36]
Chr8:8p23.3-11.23
pathogenic|likely pathogenic
GRCh38/hg38 8p23.3-12(chr8:241605-31091074)x3 copy number gain See cases [RCV000138831] Chr8:241605..31091074 [GRCh38]
Chr8:191605..30948590 [GRCh37]
Chr8:181605..31068132 [NCBI36]
Chr8:8p23.3-12
pathogenic
GRCh38/hg38 8p23.1-21.1(chr8:12382844-28625564)x3 copy number gain See cases [RCV000138244] Chr8:12382844..28625564 [GRCh38]
Chr8:12240353..28483081 [GRCh37]
Chr8:12284724..28539000 [NCBI36]
Chr8:8p23.1-21.1
pathogenic
GRCh38/hg38 8p23.3-q24.3(chr8:241605-145054781)x3 copy number gain See cases [RCV000138643] Chr8:241605..145054781 [GRCh38]
Chr8:191605..146280167 [GRCh37]
Chr8:181605..146250971 [NCBI36]
Chr8:8p23.3-q24.3
pathogenic
GRCh38/hg38 8p23.1-11.22(chr8:7141697-38695546)x3 copy number gain See cases [RCV000139891] Chr8:7141697..38695546 [GRCh38]
Chr8:6999219..38553064 [GRCh37]
Chr8:6986629..38672221 [NCBI36]
Chr8:8p23.1-11.22
pathogenic
GRCh38/hg38 8p23.1-11.22(chr8:12729023-39235934)x3 copy number gain See cases [RCV000139770] Chr8:12729023..39235934 [GRCh38]
Chr8:12586532..39093453 [GRCh37]
Chr8:12630903..39212610 [NCBI36]
Chr8:8p23.1-11.22
pathogenic
GRCh38/hg38 8p23.1-11.1(chr8:12646123-43686843)x3 copy number gain See cases [RCV000139796] Chr8:12646123..43686843 [GRCh38]
Chr8:12503632..43541986 [GRCh37]
Chr8:12548003..43661143 [NCBI36]
Chr8:8p23.1-11.1
pathogenic
GRCh38/hg38 8p23.1-11.23(chr8:11851113-37216333)x3 copy number gain See cases [RCV000139549] Chr8:11851113..37216333 [GRCh38]
Chr8:11708622..37073851 [GRCh37]
Chr8:11746031..37193009 [NCBI36]
Chr8:8p23.1-11.23
pathogenic
GRCh38/hg38 8p23.3-12(chr8:226452-34491890)x3 copy number gain See cases [RCV000141410] Chr8:226452..34491890 [GRCh38]
Chr8:176452..34349408 [GRCh37]
Chr8:166452..34468950 [NCBI36]
Chr8:8p23.3-12
pathogenic
GRCh38/hg38 8p23.3-q24.3(chr8:208048-145070385)x3 copy number gain See cases [RCV000141808] Chr8:208048..145070385 [GRCh38]
Chr8:158048..146295771 [GRCh37]
Chr8:148048..146266575 [NCBI36]
Chr8:8p23.3-q24.3
pathogenic
GRCh38/hg38 8p23.1-12(chr8:12383584-29033946)x1 copy number loss See cases [RCV000142516] Chr8:12383584..29033946 [GRCh38]
Chr8:12241093..28891463 [GRCh37]
Chr8:12285464..28947382 [NCBI36]
Chr8:8p23.1-12
pathogenic
GRCh38/hg38 8p21.3-q24.3(chr8:21291522-145070385)x3 copy number gain See cases [RCV000142021] Chr8:21291522..145070385 [GRCh38]
Chr8:21149033..146295771 [GRCh37]
Chr8:21193313..146266575 [NCBI36]
Chr8:8p21.3-q24.3
pathogenic
GRCh38/hg38 8p23.3-q24.3(chr8:226452-145068712)x3 copy number gain See cases [RCV000142858] Chr8:226452..145068712 [GRCh38]
Chr8:176452..146294098 [GRCh37]
Chr8:166452..146264902 [NCBI36]
Chr8:8p23.3-q24.3
pathogenic
GRCh38/hg38 8p22-12(chr8:18972996-33619264)x1 copy number loss See cases [RCV000142747] Chr8:18972996..33619264 [GRCh38]
Chr8:18830506..33476782 [GRCh37]
Chr8:18874786..33596324 [NCBI36]
Chr8:8p22-12
pathogenic
GRCh38/hg38 8p23.3-q24.3(chr8:241530-145054634)x3 copy number gain See cases [RCV000148092] Chr8:241530..145054634 [GRCh38]
Chr8:191530..146280020 [GRCh37]
Chr8:181530..146250824 [NCBI36]
Chr8:8p23.3-q24.3
pathogenic
GRCh38/hg38 8p23.1-11.21(chr8:12633490-40685533)x3 copy number gain See cases [RCV000143508] Chr8:12633490..40685533 [GRCh38]
Chr8:12490999..40543052 [GRCh37]
Chr8:12535370..40662209 [NCBI36]
Chr8:8p23.1-11.21
pathogenic
GRCh38/hg38 8p23.1-11.1(chr8:12728904-43673207)x3 copy number gain See cases [RCV000148237] Chr8:12728904..43673207 [GRCh38]
Chr8:12586413..43528350 [GRCh37]
Chr8:12630784..43647507 [NCBI36]
Chr8:8p23.1-11.1
pathogenic
GRCh38/hg38 8p23.1-11.21(chr8:12609975-42085703)x3 copy number gain See cases [RCV000148249] Chr8:12609975..42085703 [GRCh38]
Chr8:12467484..41943221 [GRCh37]
Chr8:12511855..42062378 [NCBI36]
Chr8:8p23.1-11.21
pathogenic
GRCh37/hg19 8p21.3-12(chr8:20478546-28986438)x3 copy number gain See cases [RCV000203434] Chr8:20478546..28986438 [GRCh37]
Chr8:8p21.3-12
pathogenic
GRCh37/hg19 8p23.1-11.22(chr8:12528482-39593802)x3 copy number gain See cases [RCV000511325] Chr8:12528482..39593802 [GRCh37]
Chr8:8p23.1-11.22
pathogenic
GRCh37/hg19 8p23.3-12(chr8:158048-30262760)x3 copy number gain See cases [RCV000449225] Chr8:158048..30262760 [GRCh37]
Chr8:8p23.3-12
pathogenic
GRCh37/hg19 8p21.2-q12.1(chr8:24772064-24813176)x3 copy number gain See cases [RCV000446588] Chr8:24772064..24813176 [GRCh37]
Chr8:8p21.2-q12.1
uncertain significance
GRCh37/hg19 8p23.3-q24.3(chr8:158991-146280828)x3 copy number gain See cases [RCV000447507] Chr8:158991..146280828 [GRCh37]
Chr8:8p23.3-q24.3
pathogenic
GRCh37/hg19 8p23.3-11.1(chr8:158048-43786723)x3 copy number gain See cases [RCV000447909] Chr8:158048..43786723 [GRCh37]
Chr8:8p23.3-11.1
pathogenic
GRCh37/hg19 8p23.1-11.1(chr8:12580132-43388233)x3 copy number gain See cases [RCV000447913] Chr8:12580132..43388233 [GRCh37]
Chr8:8p23.1-11.1
pathogenic
GRCh37/hg19 8p21.2-12(chr8:24514488-34808438) copy number gain See cases [RCV000448582] Chr8:24514488..34808438 [GRCh37]
Chr8:8p21.2-12
pathogenic
GRCh37/hg19 8p22-12(chr8:16992973-32612724)x1 copy number loss not provided [RCV000509389] Chr8:16992973..32612724 [GRCh37]
Chr8:8p22-12
not provided
GRCh37/hg19 8p23.3-q24.3(chr8:158049-146295771) copy number gain See cases [RCV000510234] Chr8:158049..146295771 [GRCh37]
Chr8:8p23.3-q24.3
pathogenic
GRCh37/hg19 8p23.1-12(chr8:12528482-33684786)x3 copy number gain See cases [RCV000510571] Chr8:12528482..33684786 [GRCh37]
Chr8:8p23.1-12
pathogenic
GRCh37/hg19 8p23.1-11.1(chr8:11935023-43824035)x3 copy number gain See cases [RCV000511028] Chr8:11935023..43824035 [GRCh37]
Chr8:8p23.1-11.1
pathogenic
GRCh37/hg19 8p23.1-12(chr8:11945855-34875355)x3 copy number gain See cases [RCV000510899] Chr8:11945855..34875355 [GRCh37]
Chr8:8p23.1-12
pathogenic
GRCh37/hg19 8p23.3-q24.3(chr8:158049-146295771)x3 copy number gain See cases [RCV000511095] Chr8:158049..146295771 [GRCh37]
Chr8:8p23.3-q24.3
pathogenic
NM_001831.4(CLU):c.608C>T (p.Thr203Ile) single nucleotide variant Alzheimer disease [RCV000590968]|not provided [RCV000955185] Chr8:27605145 [GRCh38]
Chr8:27462662 [GRCh37]
Chr8:8p21.1
likely benign
GRCh37/hg19 8p23.1-q24.3(chr8:12490999-146295771)x3 copy number gain See cases [RCV000512169] Chr8:12490999..146295771 [GRCh37]
Chr8:8p23.1-q24.3
pathogenic
GRCh37/hg19 8p23.1-12(chr8:12552775-35935825)x3 copy number gain not provided [RCV000683043] Chr8:12552775..35935825 [GRCh37]
Chr8:8p23.1-12
pathogenic
GRCh37/hg19 8p23.3-q24.3(chr8:164984-146293414)x3 copy number gain not provided [RCV000747254] Chr8:164984..146293414 [GRCh37]
Chr8:8p23.3-q24.3
pathogenic
GRCh37/hg19 8p23.3-q24.3(chr8:10213-146293414)x3 copy number gain not provided [RCV000747248] Chr8:10213..146293414 [GRCh37]
Chr8:8p23.3-q24.3
pathogenic
GRCh37/hg19 8p23.1-12(chr8:12556004-34374150)x3 copy number gain not provided [RCV000762735] Chr8:12556004..34374150 [GRCh37]
Chr8:8p23.1-12
likely pathogenic
NM_001831.4(CLU):c.756C>T (p.His252=) single nucleotide variant not provided [RCV000904406] Chr8:27604997 [GRCh38]
Chr8:27462514 [GRCh37]
Chr8:8p21.1
likely benign
NM_001831.4(CLU):c.382G>A (p.Val128Ile) single nucleotide variant not provided [RCV000901031] Chr8:27606389 [GRCh38]
Chr8:27463906 [GRCh37]
Chr8:8p21.1
benign
NM_001831.4(CLU):c.705C>T (p.Tyr235=) single nucleotide variant not provided [RCV000983110] Chr8:27605048 [GRCh38]
Chr8:27462565 [GRCh37]
Chr8:8p21.1
likely benign
NM_001831.4(CLU):c.984C>T (p.Asp328=) single nucleotide variant not provided [RCV000971373] Chr8:27599960 [GRCh38]
Chr8:27457477 [GRCh37]
Chr8:8p21.1
benign
GRCh37/hg19 8p21.2-21.1(chr8:24305969-28673405)x1 copy number loss not provided [RCV001006090] Chr8:24305969..28673405 [GRCh37]
Chr8:8p21.2-21.1
pathogenic
Single allele duplication not provided [RCV000768452] Chr8:12546855..35816855 [GRCh37]
Chr8:8p23.1-12
likely pathogenic
NM_001831.4(CLU):c.417+8G>C single nucleotide variant not provided [RCV000925508] Chr8:27606346 [GRCh38]
Chr8:27463863 [GRCh37]
Chr8:8p21.1
benign
NM_001831.4(CLU):c.564C>T (p.Asp188=) single nucleotide variant not provided [RCV000922206] Chr8:27605189 [GRCh38]
Chr8:27462706 [GRCh37]
Chr8:8p21.1
likely benign
NM_001831.4(CLU):c.999C>T (p.Val333=) single nucleotide variant not provided [RCV000915760] Chr8:27599945 [GRCh38]
Chr8:27457462 [GRCh37]
Chr8:8p21.1
likely benign
GRCh37/hg19 8p23.3-q24.3(chr8:158048-146295771)x3 copy number gain not provided [RCV000848478] Chr8:158048..146295771 [GRCh37]
Chr8:8p23.3-q24.3
pathogenic
NM_001831.4(CLU):c.1314G>T (p.Ala438=) single nucleotide variant not provided [RCV000885211] Chr8:27598486 [GRCh38]
Chr8:27456003 [GRCh37]
Chr8:8p21.1
likely benign
NM_001831.4(CLU):c.1187C>T (p.Ser396Leu) single nucleotide variant not provided [RCV000888734] Chr8:27598613 [GRCh38]
Chr8:27456130 [GRCh37]
Chr8:8p21.1
benign
NM_001831.4(CLU):c.123C>T (p.Tyr41=) single nucleotide variant not provided [RCV000888113] Chr8:27609061 [GRCh38]
Chr8:27466578 [GRCh37]
Chr8:8p21.1
benign
NM_001831.4(CLU):c.75G>A (p.Thr25=) single nucleotide variant not provided [RCV000974218] Chr8:27610497 [GRCh38]
Chr8:27468014 [GRCh37]
Chr8:8p21.1
likely benign
NM_001831.4(CLU):c.1191C>T (p.Asp397=) single nucleotide variant not provided [RCV000910373] Chr8:27598609 [GRCh38]
Chr8:27456126 [GRCh37]
Chr8:8p21.1
benign
NM_001831.4(CLU):c.954C>G (p.Pro318=) single nucleotide variant not provided [RCV000956582] Chr8:27599990 [GRCh38]
Chr8:27457507 [GRCh37]
Chr8:8p21.1
benign
NM_001831.4(CLU):c.982G>A (p.Asp328Asn) single nucleotide variant not provided [RCV000956581] Chr8:27599962 [GRCh38]
Chr8:27457479 [GRCh37]
Chr8:8p21.1
benign
GRCh37/hg19 8p21.1(chr8:27417421-27643275)x3 copy number gain not provided [RCV001259473] Chr8:27417421..27643275 [GRCh37]
Chr8:8p21.1
uncertain significance
GRCh37/hg19 8p23.1-12(chr8:12528482-29886483)x3 copy number gain not provided [RCV001260030] Chr8:12528482..29886483 [GRCh37]
Chr8:8p23.1-12
likely pathogenic

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:2095 AgrOrtholog
COSMIC CLU COSMIC
Ensembl Genes ENSG00000120885 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSP00000315130 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000385419 UniProtKB/Swiss-Prot
  ENSP00000427868 UniProtKB/TrEMBL
  ENSP00000428033 UniProtKB/TrEMBL
  ENSP00000428526 UniProtKB/TrEMBL
  ENSP00000428779 UniProtKB/TrEMBL
  ENSP00000429087 UniProtKB/TrEMBL
  ENSP00000429336 UniProtKB/TrEMBL
  ENSP00000429620 UniProtKB/Swiss-Prot
  ENSP00000429881 UniProtKB/TrEMBL
  ENSP00000430821 UniProtKB/TrEMBL
  ENSP00000431026 UniProtKB/TrEMBL
  ENSP00000431070 UniProtKB/TrEMBL
  ENSP00000453247 UniProtKB/TrEMBL
Ensembl Transcript ENST00000316403 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000405140 UniProtKB/Swiss-Prot
  ENST00000519472 UniProtKB/TrEMBL
  ENST00000519742 UniProtKB/TrEMBL
  ENST00000520491 UniProtKB/TrEMBL
  ENST00000520796 UniProtKB/TrEMBL
  ENST00000521770 UniProtKB/TrEMBL
  ENST00000522098 UniProtKB/TrEMBL
  ENST00000522238 UniProtKB/TrEMBL
  ENST00000522413 UniProtKB/TrEMBL
  ENST00000523396 UniProtKB/TrEMBL
  ENST00000523500 UniProtKB/Swiss-Prot
  ENST00000523589 UniProtKB/TrEMBL
  ENST00000560566 UniProtKB/TrEMBL
GTEx ENSG00000120885 GTEx
HGNC ID HGNC:2095 ENTREZGENE
Human Proteome Map CLU Human Proteome Map
InterPro Clusterin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Clusterin-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Clusterin_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Clusterin_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Clusterin_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:1191 UniProtKB/Swiss-Prot
NCBI Gene 1191 ENTREZGENE
OMIM 185430 OMIM
PANTHER PTHR10970 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR10970:SF1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Clusterin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA26620 PharmGKB
PIRSF Clusterin UniProtKB/Swiss-Prot
PROSITE CLUSTERIN_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CLUSTERIN_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART CLa UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CLb UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt CLUS_HUMAN UniProtKB/Swiss-Prot
  E5RG36_HUMAN UniProtKB/TrEMBL
  E5RGB0_HUMAN UniProtKB/TrEMBL
  E5RH61_HUMAN UniProtKB/TrEMBL
  E5RJD6_HUMAN UniProtKB/TrEMBL
  E5RJZ5_HUMAN UniProtKB/TrEMBL
  E7ERK6_HUMAN UniProtKB/TrEMBL
  E7ETB4_HUMAN UniProtKB/TrEMBL
  H0YAS8_HUMAN UniProtKB/TrEMBL
  H0YC35_HUMAN UniProtKB/TrEMBL
  H0YLK8_HUMAN UniProtKB/TrEMBL
  P10909 ENTREZGENE
  Q8IWM0_HUMAN UniProtKB/TrEMBL
UniProt Secondary B2R9Q1 UniProtKB/Swiss-Prot
  B3KSE6 UniProtKB/Swiss-Prot
  P11380 UniProtKB/Swiss-Prot
  P11381 UniProtKB/Swiss-Prot
  Q2TU75 UniProtKB/Swiss-Prot
  Q5HYC1 UniProtKB/Swiss-Prot
  Q7Z5B9 UniProtKB/Swiss-Prot