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Gene: CLU (clusterin) Homo sapiens
Symbol: CLU
Name: clusterin
Description: Exhibits several functions, including amyloid-beta binding activity; low-density lipoprotein particle receptor binding activity; and misfolded protein binding activity. Involved in several processes, including positive regulation of cellular component organization; regulation of intrinsic apoptotic signaling pathway; and regulation of protein metabolic process. Localizes to several cellular components, including the neurofibrillary tangle; perinuclear endoplasmic reticulum lumen; and spherical high-density lipoprotein particle. Colocalizes with the cell periphery; cytoskeleton; and membrane. Implicated in artery disease (multiple); breast cancer; diabetic retinopathy; exfoliation syndrome; and muscular disease (multiple). Biomarker of several diseases, including Kawasaki disease; Stevens-Johnson syndrome; cicatricial pemphigoid; eye disease (multiple); and rheumatic disease (multiple).
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: AAG4; aging-associated protein 4; APO-J; APOJ; apolipoprotein J; CLI; CLU1; CLU2; complement cytolysis inhibitor; complement lysis inhibitor; complement-associated protein SP-40,40; ku70-binding protein 1; KUB1; MGC24903; NA1/NA2; SGP-2; SGP2; SP-40; sulfated glycoprotein 2; testosterone-repressed prostate message 2; TRPM-2; TRPM2
Mus musculus (house mouse) : Clu (clusterin)  MGI  Alliance
Rattus norvegicus (Norway rat) : Clu (clusterin)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Clu (clusterin)
Pan paniscus (bonobo/pygmy chimpanzee) : CLU (clusterin)
Canis lupus familiaris (dog) : CLU (clusterin)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Clu (clusterin)
Sus scrofa (pig) : CLU (clusterin)
Chlorocebus sabaeus (green monkey) : CLU (clusterin)
Heterocephalus glaber (naked mole-rat) : Clu (clusterin)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl827,596,917 - 27,614,700 (-)Ensembl
GRCh38827,596,917 - 27,615,031 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37827,454,434 - 27,472,328 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36827,510,368 - 27,528,244 (-)NCBINCBI36hg18NCBI36
Build 34827,510,367 - 27,524,855NCBI
Celera826,414,541 - 26,432,416 (-)NCBI
Cytogenetic Map8p21.1NCBI
HuRef825,999,468 - 26,017,387 (-)NCBIHuRef
CHM1_1827,656,307 - 27,674,217 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
More on CLU
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 68978
Created: 2001-11-06
Species: Homo sapiens
Last Modified: 2020-02-11
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.