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Gene: CSNK1A1 (casein kinase 1 alpha 1) Homo sapiens
Symbol: CSNK1A1
Name: casein kinase 1 alpha 1
Description: Exhibits protein serine/threonine kinase activity. Involved in several processes, including negative regulation of canonical Wnt signaling pathway; peptidyl-serine phosphorylation; and positive regulation of proteasomal ubiquitin-dependent protein catabolic process. Localizes to several cellular components, including beta-catenin destruction complex; centrosome; and nuclear speck. Colocalizes with keratin filament and mRNA cleavage and polyadenylation specificity factor complex. Biomarker of Alzheimer's disease and inclusion body myositis; PARTICIPATES IN Hedgehog signaling pathway; p53 signaling pathway; Wnt signaling, non-canonical pathway; INTERACTS WITH (-)-demecolcine; 17beta-hydroxy-17-methylestra-4,9,11-trien-3-one; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: casein kinase 1, alpha 1; casein kinase I isoform alpha; CK1; CK1a; CK1alpha; CKI-alpha; CKIa; CKIalpha; clock regulator kinase; down-regulated in lung cancer; epididymis secretory sperm binding protein Li 77p; HEL-S-77p; HLCDGP1; PRO2975
Mus musculus (house mouse) : Csnk1a1 (casein kinase 1, alpha 1)  MGI  Alliance
Rattus norvegicus (Norway rat) : Csnk1a1 (casein kinase 1, alpha 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Csnk1a1 (casein kinase 1 alpha 1)
Pan paniscus (bonobo/pygmy chimpanzee) : CSNK1A1 (casein kinase 1 alpha 1)
Canis lupus familiaris (dog) : CSNK1A1 (casein kinase 1 alpha 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Csnk1a1 (casein kinase 1 alpha 1)
Sus scrofa (pig) : CSNK1A1 (casein kinase 1 alpha 1)
Chlorocebus sabaeus (African green monkey) : CSNK1A1 (casein kinase 1 alpha 1)
Heterocephalus glaber (naked mole-rat) : Csnk1a1 (casein kinase 1 alpha 1)
more info ...
Related Pseudogenes: CSNK1A1P1   CSNK1A1P2   CSNK1A1P3  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl5149,492,982 - 149,551,471 (-)EnsemblGRCh38hg38GRCh38
GRCh385149,492,982 - 149,551,439 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh375148,873,896 - 148,931,115 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 365148,855,038 - 148,911,200 (-)NCBINCBI36hg18NCBI36
Build 345148,855,741 - 148,910,850NCBI
Celera5144,956,788 - 145,012,931 (-)NCBI
Cytogenetic Map5q32NCBI
HuRef5144,021,796 - 144,077,664 (-)NCBIHuRef
CHM1_15148,307,871 - 148,363,537 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on CSNK1A1
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 736167
Created: 2004-02-06
Species: Homo sapiens
Last Modified: 2020-05-26
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.