PA2G4 (proliferation-associated 2G4) - Rat Genome Database

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Gene: PA2G4 (proliferation-associated 2G4) Homo sapiens
Analyze
Symbol: PA2G4
Name: proliferation-associated 2G4
RGD ID: 1354307
HGNC Page HGNC:8550
Description: Enables nucleic acid binding activity; transcription corepressor activity; and ubiquitin protein ligase binding activity. Acts upstream of or within negative regulation of DNA-templated transcription. Located in cytoplasm and nucleolus.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: cell cycle protein p38-2G4 homolog; EBP1; ErbB-3 binding protein 1; erbB3-binding protein 1; ErbB3-binding protein Ebp1; HG4-1; IRES-specific cellular transacting factor 45; ITAF45; p38-2G4; proliferation-associated 2G4, 38kD; proliferation-associated 2G4, 38kDa; proliferation-associated protein 2G4
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Related Pseudogenes: PA2G4P1   PA2G4P2   PA2G4P3   PA2G4P4   PA2G4P5   PA2G4P6  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381256,104,559 - 56,113,910 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1256,104,537 - 56,113,910 (+)EnsemblGRCh38hg38GRCh38
GRCh371256,498,343 - 56,507,694 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361254,784,370 - 54,793,961 (+)NCBINCBI36Build 36hg18NCBI36
Build 341254,784,691 - 54,793,353NCBI
Celera1256,150,290 - 56,159,843 (+)NCBICelera
Cytogenetic Map12q13.2NCBI
HuRef1253,537,242 - 53,546,835 (+)NCBIHuRef
CHM1_11256,465,468 - 56,475,059 (+)NCBICHM1_1
T2T-CHM13v2.01256,072,163 - 56,081,516 (+)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (ISO)
(-)-epigallocatechin 3-gallate  (EXP)
1,2-dichloroethane  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP)
17beta-hydroxy-17-methylestra-4,9,11-trien-3-one  (EXP)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,4-dinitrotoluene  (ISO)
2,6-dinitrotoluene  (ISO)
2-amino-14,16-dimethyloctadecan-3-ol  (EXP)
2-hydroxypropanoic acid  (EXP)
3,3',4,4'-tetrachlorobiphenyl  (ISO)
4,4'-sulfonyldiphenol  (EXP)
4-amino-2,6-dinitrotoluene  (ISO)
4-hydroxynon-2-enal  (ISO)
6-propyl-2-thiouracil  (ISO)
aflatoxin B1  (EXP)
all-trans-retinoic acid  (EXP)
ampicillin  (EXP)
aristolochic acid A  (EXP)
arsenite(3-)  (EXP)
belinostat  (EXP)
benzatropine  (EXP)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
bicalutamide  (EXP)
bisphenol A  (EXP,ISO)
Bisphenol B  (EXP)
bisphenol F  (EXP)
cadmium dichloride  (ISO)
caffeine  (EXP)
carbon nanotube  (EXP,ISO)
CGP 52608  (EXP)
chloropicrin  (EXP)
chlorpyrifos  (ISO)
choline  (ISO)
chromium(6+)  (ISO)
chrysene  (ISO)
cisplatin  (EXP,ISO)
clofibric acid  (ISO)
cobalt dichloride  (EXP)
cocaine  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
Cuprizon  (EXP)
cycloheximide  (EXP)
cyclosporin A  (EXP,ISO)
cyproterone acetate  (EXP)
dibutyl phthalate  (ISO)
diethylstilbestrol  (EXP)
dioxygen  (ISO)
doxorubicin  (ISO)
elemental selenium  (EXP)
enzyme inhibitor  (EXP)
fenthion  (ISO)
finasteride  (ISO)
flutamide  (ISO)
folic acid  (EXP,ISO)
FR900359  (EXP)
fulvestrant  (EXP)
genistein  (EXP)
gentamycin  (ISO)
geraniol  (EXP)
glafenine  (ISO)
graphite  (EXP)
hydrogen peroxide  (EXP)
hydroquinone  (EXP)
ivermectin  (EXP)
L-methionine  (ISO)
lead diacetate  (ISO)
lovastatin  (ISO)
methidathion  (ISO)
miconazole  (ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (ISO)
N-nitrosodiethylamine  (ISO)
nefazodone  (ISO)
nimesulide  (ISO)
oxaliplatin  (ISO)
ozone  (ISO)
paraquat  (ISO)
phenobarbital  (ISO)
piroxicam  (EXP)
quercetin  (EXP)
rac-lactic acid  (EXP)
selenium atom  (EXP)
silicon dioxide  (EXP)
sodium arsenite  (EXP)
sodium dichromate  (ISO)
sunitinib  (EXP)
T-2 toxin  (ISO)
tamoxifen  (EXP,ISO)
tanespimycin  (EXP)
tetrachloromethane  (ISO)
tetraphene  (ISO)
thioacetamide  (ISO)
topotecan  (ISO)
trimellitic anhydride  (ISO)
valproic acid  (ISO)
vitamin E  (EXP)
warfarin  (ISO)
zinc sulfate  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Human Phenotype
References

References - curated
# Reference Title Reference Citation
1. GOAs Human GO annotations GOA_HUMAN data from the GO Consortium
2. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
4. The long non-coding RNA H19 promotes cardiomyocyte apoptosis in dilated cardiomyopathy. Zhang Y, etal., Oncotarget. 2017 Apr 25;8(17):28588-28594. doi: 10.18632/oncotarget.15544.
Additional References at PubMed
PMID:7556453   PMID:8889548   PMID:9345902   PMID:9565586   PMID:10608806   PMID:10682683   PMID:10797306   PMID:11268000   PMID:11325528   PMID:11708806   PMID:11790298   PMID:12165860  
PMID:12429849   PMID:12477932   PMID:12682367   PMID:15064750   PMID:15073182   PMID:15231747   PMID:15489334   PMID:15583694   PMID:15635413   PMID:15896331   PMID:15994225   PMID:16236267  
PMID:16254079   PMID:16396631   PMID:16631606   PMID:16642037   PMID:16832058   PMID:16964243   PMID:17081983   PMID:17295834   PMID:17316401   PMID:17353931   PMID:17641068   PMID:17765895  
PMID:17768350   PMID:17951246   PMID:18029348   PMID:18337751   PMID:18355957   PMID:18850631   PMID:18852121   PMID:19037095   PMID:19615732   PMID:19738201   PMID:19946338   PMID:19946888  
PMID:20048076   PMID:20211142   PMID:20348541   PMID:20360068   PMID:20379846   PMID:20458337   PMID:20562859   PMID:21044950   PMID:21081666   PMID:21085677   PMID:21098709   PMID:21145366  
PMID:21319273   PMID:21794029   PMID:21873635   PMID:21930127   PMID:21965718   PMID:22623428   PMID:22658674   PMID:22863883   PMID:22939629   PMID:22944692   PMID:22951725   PMID:22990118  
PMID:23110497   PMID:23242156   PMID:23246001   PMID:23283744   PMID:23472066   PMID:23707440   PMID:23828502   PMID:24583282   PMID:24651434   PMID:24711643   PMID:24798454   PMID:24981860  
PMID:25154617   PMID:25437307   PMID:25609649   PMID:25691158   PMID:25796446   PMID:25917452   PMID:25921289   PMID:25940091   PMID:25959826   PMID:25963833   PMID:26081906   PMID:26186194  
PMID:26256794   PMID:26269332   PMID:26343856   PMID:26344197   PMID:26436510   PMID:26496610   PMID:26549023   PMID:26638075   PMID:26641092   PMID:26813358   PMID:26831064   PMID:27025967  
PMID:27082860   PMID:27118868   PMID:27173435   PMID:27432908   PMID:27464702   PMID:27684187   PMID:28209614   PMID:28302793   PMID:28330616   PMID:28514442   PMID:28515276   PMID:28869606  
PMID:29298432   PMID:29467282   PMID:29509190   PMID:29872149   PMID:29955894   PMID:30021884   PMID:30076717   PMID:30196744   PMID:30224479   PMID:30320910   PMID:30425250   PMID:30463901  
PMID:30793766   PMID:30833792   PMID:30890647   PMID:30948266   PMID:30997501   PMID:31046837   PMID:31048545   PMID:31059266   PMID:31073040   PMID:31300519   PMID:31363146   PMID:31501192  
PMID:31527615   PMID:31586073   PMID:31828582   PMID:32034140   PMID:32049412   PMID:32051553   PMID:32086588   PMID:32129710   PMID:32203420   PMID:32269044   PMID:32416067   PMID:32529326  
PMID:32683582   PMID:32687490   PMID:32707033   PMID:32780723   PMID:32807901   PMID:32941674   PMID:32952126   PMID:32963011   PMID:32994395   PMID:33150374   PMID:33194618   PMID:33220287  
PMID:33306668   PMID:33397691   PMID:33529238   PMID:33605574   PMID:33634940   PMID:33691908   PMID:33742100   PMID:33916271   PMID:33957083   PMID:33961781   PMID:34079125   PMID:34091597  
PMID:34133714   PMID:34185411   PMID:34428256   PMID:34591612   PMID:34709727   PMID:34728620   PMID:34901782   PMID:35013556   PMID:35253629   PMID:35256949   PMID:35271311   PMID:35446349  
PMID:35509820   PMID:35676659   PMID:35681168   PMID:35831314   PMID:35906200   PMID:35944360   PMID:36065190   PMID:36215168   PMID:36244648   PMID:36273042   PMID:36373674   PMID:36423778  
PMID:36517590   PMID:36526897   PMID:36606322   PMID:36762613   PMID:37774976   PMID:37827155   PMID:38113892  


Genomics

Comparative Map Data
PA2G4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381256,104,559 - 56,113,910 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1256,104,537 - 56,113,910 (+)EnsemblGRCh38hg38GRCh38
GRCh371256,498,343 - 56,507,694 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361254,784,370 - 54,793,961 (+)NCBINCBI36Build 36hg18NCBI36
Build 341254,784,691 - 54,793,353NCBI
Celera1256,150,290 - 56,159,843 (+)NCBICelera
Cytogenetic Map12q13.2NCBI
HuRef1253,537,242 - 53,546,835 (+)NCBIHuRef
CHM1_11256,465,468 - 56,475,059 (+)NCBICHM1_1
T2T-CHM13v2.01256,072,163 - 56,081,516 (+)NCBIT2T-CHM13v2.0
Pa2g4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3910128,393,635 - 128,401,803 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl10128,393,635 - 128,401,856 (-)EnsemblGRCm39 Ensembl
GRCm3810128,557,766 - 128,565,934 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl10128,557,766 - 128,565,987 (-)EnsemblGRCm38mm10GRCm38
MGSCv3710127,994,822 - 128,002,990 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3610127,961,592 - 127,968,897 (-)NCBIMGSCv36mm8
Celera10130,949,754 - 130,957,922 (-)NCBICelera
Cytogenetic Map10D3NCBI
cM Map1077.09NCBI
Pa2g4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr871,569,326 - 1,576,794 (-)NCBIGRCr8
mRatBN7.27984,795 - 992,264 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7983,971 - 992,331 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx73,746,905 - 3,754,373 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.075,622,896 - 5,630,363 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.075,920,502 - 5,927,971 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.072,979,587 - 2,987,055 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl72,979,588 - 2,987,055 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.072,952,383 - 2,960,679 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.471,846,628 - 1,854,096 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.171,846,628 - 1,854,096 (-)NCBI
Celera7855,183 - 862,626 (-)NCBICelera
Cytogenetic Map7q11NCBI
Pa2g4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554583,705,704 - 3,717,403 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554583,705,704 - 3,715,782 (+)NCBIChiLan1.0ChiLan1.0
PA2G4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21038,218,516 - 38,227,001 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11238,214,527 - 38,224,146 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01232,801,085 - 32,810,441 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11233,051,672 - 33,061,262 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1233,051,672 - 33,061,262 (-)Ensemblpanpan1.1panPan2
PA2G4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.110426,074 - 437,044 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl10426,069 - 434,767 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha10487,811 - 499,123 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.010432,937 - 444,249 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl10432,930 - 441,669 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.110410,400 - 421,711 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.010653,296 - 664,836 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.010777,521 - 788,835 (+)NCBIUU_Cfam_GSD_1.0
Pa2g4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494558,345,893 - 58,353,962 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936646516,265 - 524,481 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936646516,273 - 523,572 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PA2G4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1521,495,997 - 21,503,297 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2523,103,723 - 23,106,699 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PA2G4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11152,044,845 - 52,054,545 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666037193,930,133 - 193,940,436 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pa2g4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462480211,896,285 - 11,904,756 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462480211,896,285 - 11,904,989 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in PA2G4
1 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
NM_001982.3(ERBB3):c.3145A>G (p.Ser1049Gly) single nucleotide variant Malignant melanoma [RCV000062558] Chr12:56100189 [GRCh38]
Chr12:56493973 [GRCh37]
Chr12:54780240 [NCBI36]
Chr12:12q13.2		 not provided
GRCh38/hg38 12p13.33-q24.33(chr12:121271-133196807)x3 copy number gain See cases [RCV000139555] Chr12:121271..133196807 [GRCh38]
Chr12:282465..133773393 [GRCh37]
Chr12:100698..132283466 [NCBI36]
Chr12:12p13.33-q24.33		 pathogenic
GRCh38/hg38 12q13.13-13.3(chr12:53420606-56202942)x3 copy number gain See cases [RCV000141435] Chr12:53420606..56202942 [GRCh38]
Chr12:53814390..56596726 [GRCh37]
Chr12:52100657..54882993 [NCBI36]
Chr12:12q13.13-13.3		 pathogenic
GRCh37/hg19 12p13.33-q24.33(chr12:1-133851895)x3 copy number gain See cases [RCV000258805] Chr12:1..133851895 [GRCh37]
Chr12:12p13.33-q24.33		 pathogenic|likely pathogenic
GRCh37/hg19 12q13.2(chr12:55975308-56593032)x3 copy number gain See cases [RCV000446219] Chr12:55975308..56593032 [GRCh37]
Chr12:12q13.2		 uncertain significance
GRCh37/hg19 12p13.33-q24.33(chr12:173787-133777902)x3 copy number gain See cases [RCV000510482] Chr12:173787..133777902 [GRCh37]
Chr12:12p13.33-q24.33		 pathogenic
GRCh37/hg19 12p13.33-q24.33(chr12:173787-133777902) copy number gain See cases [RCV000511643] Chr12:173787..133777902 [GRCh37]
Chr12:12p13.33-q24.33		 pathogenic
GRCh37/hg19 12p13.33-q24.33(chr12:191619-133777645)x3 copy number gain not provided [RCV000750246] Chr12:191619..133777645 [GRCh37]
Chr12:12p13.33-q24.33		 pathogenic
GRCh37/hg19 12p13.33-q24.33(chr12:621220-133779118)x3 copy number gain not provided [RCV000750253] Chr12:621220..133779118 [GRCh37]
Chr12:12p13.33-q24.33		 pathogenic
GRCh37/hg19 12q13.2-14.1(chr12:55552371-62126304)x3 copy number gain not provided [RCV001006505] Chr12:55552371..62126304 [GRCh37]
Chr12:12q13.2-14.1		 pathogenic
GRCh37/hg19 12q13.2(chr12:56333246-56558418)x3 copy number gain not provided [RCV001259615] Chr12:56333246..56558418 [GRCh37]
Chr12:12q13.2		 uncertain significance
GRCh37/hg19 12q13.2-13.3(chr12:56333262-57010442) copy number gain not specified [RCV002052997] Chr12:56333262..57010442 [GRCh37]
Chr12:12q13.2-13.3		 uncertain significance
GRCh37/hg19 12q13.2(chr12:55975308-56593032) copy number gain not specified [RCV002052996] Chr12:55975308..56593032 [GRCh37]
Chr12:12q13.2		 uncertain significance
NC_000012.11:g.(?_56396006)_(56750355_?)dup duplication Sulfite oxidase deficiency [RCV001913847] Chr12:56396006..56750355 [GRCh37]
Chr12:12q13.2-13.3		 uncertain significance
Single allele duplication not specified [RCV002286382] Chr12:55986511..56885590 [GRCh38]
Chr12:12q13.2-13.3		 uncertain significance
NM_006191.3(PA2G4):c.617C>T (p.Thr206Ile) single nucleotide variant not specified [RCV004170674] Chr12:56109923 [GRCh38]
Chr12:56503707 [GRCh37]
Chr12:12q13.2		 uncertain significance
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1526
Count of miRNA genes:819
Interacting mature miRNAs:931
Transcripts:ENST00000303305, ENST00000550166, ENST00000551061, ENST00000552266, ENST00000552528, ENST00000552766, ENST00000553057
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Markers in Region
WI-16415  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371256,497,128 - 56,497,252UniSTSGRCh37
Build 361254,783,395 - 54,783,519RGDNCBI36
Celera1256,149,315 - 56,149,439RGD
Cytogenetic Map12q13UniSTS
Cytogenetic Map12q13.2UniSTS
HuRef1253,536,267 - 53,536,391UniSTS
GeneMap99-GB4 RH Map12246.43UniSTS
Whitehead-RH Map12345.3UniSTS
NCBI RH Map12458.1UniSTS
RH80204  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371256,507,853 - 56,508,031UniSTSGRCh37
Build 361254,794,120 - 54,794,298RGDNCBI36
Celera1256,160,002 - 56,160,180RGD
Cytogenetic Map12q13.2UniSTS
HuRef1253,546,994 - 53,547,172UniSTS
GeneMap99-GB4 RH Map12247.2UniSTS
RH79880  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh372012,361,497 - 12,361,785UniSTSGRCh37
GRCh373156,527,445 - 156,527,733UniSTSGRCh37
Build 363158,010,139 - 158,010,427RGDNCBI36
Celera2012,431,690 - 12,431,978UniSTS
Celera3154,951,022 - 154,951,310RGD
Cytogenetic Map20p12.1UniSTS
Cytogenetic Map12q13.2UniSTS
Cytogenetic Map3q25.31UniSTS
HuRef2012,313,337 - 12,313,625UniSTS
HuRef3153,923,982 - 153,924,270UniSTS
RH48706  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh372012,360,692 - 12,360,818UniSTSGRCh37
GRCh373156,528,411 - 156,528,533UniSTSGRCh37
Build 363158,011,105 - 158,011,227RGDNCBI36
Celera2012,430,885 - 12,431,011UniSTS
Celera3154,951,988 - 154,952,110RGD
Cytogenetic Map20p12.1UniSTS
Cytogenetic Map12q13.2UniSTS
Cytogenetic Map3q25.31UniSTS
HuRef2012,312,532 - 12,312,658UniSTS
HuRef3153,924,948 - 153,925,070UniSTS
D12S1388E  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371256,497,076 - 56,497,181UniSTSGRCh37
Build 361254,783,343 - 54,783,448RGDNCBI36
Celera1256,149,263 - 56,149,368RGD
Cytogenetic Map12q13UniSTS
Cytogenetic Map12q13.2UniSTS
HuRef1253,536,215 - 53,536,320UniSTS
MARC_9801-9802:996688619:1  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh373156,527,615 - 156,527,949UniSTSGRCh37
GRCh371256,503,663 - 56,504,812UniSTSGRCh37
Build 363158,010,309 - 158,010,643RGDNCBI36
Celera1256,155,849 - 56,156,998UniSTS
Celera3154,951,192 - 154,951,526RGD
HuRef3153,924,152 - 153,924,486UniSTS
HuRef1253,542,802 - 53,543,951UniSTS
STS-R87726  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371256,507,498 - 56,507,624UniSTSGRCh37
Build 361254,793,765 - 54,793,891RGDNCBI36
Celera1256,159,647 - 56,159,773RGD
Cytogenetic Map12q13.2UniSTS
HuRef1253,546,639 - 53,546,765UniSTS
GeneMap99-GB4 RH Map12247.48UniSTS
NCBI RH Map12455.8UniSTS
RK1196_1197  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371256,496,194 - 56,496,477UniSTSGRCh37
Build 361254,782,461 - 54,782,744RGDNCBI36
Celera1256,148,379 - 56,148,662RGD
Cytogenetic Map12q13UniSTS
Cytogenetic Map12q13.2UniSTS
HuRef1253,535,330 - 53,535,613UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component pharyngeal arch
High 2
Medium 2439 2929 1721 619 1946 460 4357 2137 3682 418 1458 1613 175 1 1204 2788 6 2
Low 62 5 5 5 5 60 52 1
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_006191 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC034102 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH007267 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK291796 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC001951 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC007561 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC019222 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC032111 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC069786 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC072007 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BU683753 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471054 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068266 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KT584810 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U50137 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U59435 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U87954 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000303305   ⟹   ENSP00000302886
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1256,104,559 - 56,113,910 (+)Ensembl
RefSeq Acc Id: ENST00000550166
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1256,106,693 - 56,109,928 (+)Ensembl
RefSeq Acc Id: ENST00000551061   ⟹   ENSP00000447389
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1256,106,162 - 56,107,219 (+)Ensembl
RefSeq Acc Id: ENST00000552266
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1256,110,565 - 56,111,509 (+)Ensembl
RefSeq Acc Id: ENST00000552528
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1256,109,869 - 56,110,620 (+)Ensembl
RefSeq Acc Id: ENST00000552766   ⟹   ENSP00000448557
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1256,104,537 - 56,113,907 (+)Ensembl
RefSeq Acc Id: ENST00000553057   ⟹   ENSP00000447615
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1256,104,919 - 56,109,901 (+)Ensembl
RefSeq Acc Id: NM_006191   ⟹   NP_006182
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381256,104,559 - 56,113,910 (+)NCBI
GRCh371256,498,103 - 56,507,694 (+)ENTREZGENE
Build 361254,784,370 - 54,793,961 (+)NCBI Archive
HuRef1253,537,242 - 53,546,835 (+)ENTREZGENE
CHM1_11256,465,468 - 56,475,059 (+)NCBI
T2T-CHM13v2.01256,072,163 - 56,081,516 (+)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_006182   ⟸   NM_006191
- UniProtKB: O43846 (UniProtKB/Swiss-Prot),   Q9UM59 (UniProtKB/Swiss-Prot),   Q9UQ80 (UniProtKB/Swiss-Prot),   A8K6Y1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSP00000447389   ⟸   ENST00000551061
RefSeq Acc Id: ENSP00000448557   ⟸   ENST00000552766
RefSeq Acc Id: ENSP00000447615   ⟸   ENST00000553057
RefSeq Acc Id: ENSP00000302886   ⟸   ENST00000303305
Protein Domains
Peptidase M24

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9UQ80-F1-model_v2 AlphaFold Q9UQ80 1-394 view protein structure

Promoters
RGD ID:6790343
Promoter ID:HG_KWN:15883
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   CD4+TCell_2Hour,   HeLa_S3,   Jurkat,   K562,   Lymphoblastoid,   NB4
Transcripts:NM_006191,   UC009ZOL.1,   UC009ZOM.1
Position:
Human AssemblyChrPosition (strand)Source
Build 361254,784,186 - 54,784,707 (+)MPROMDB
RGD ID:7224367
Promoter ID:EPDNEW_H17929
Type:initiation region
Name:PA2G4_2
Description:proliferation-associated 2G4
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H17930  EPDNEW_H17931  EPDNEW_H17932  EPDNEW_H17933  EPDNEW_H17934  
Experiment Methods:Single-end sequencing.; Paired-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381256,104,291 - 56,104,351EPDNEW
RGD ID:7224369
Promoter ID:EPDNEW_H17930
Type:initiation region
Name:PA2G4_1
Description:proliferation-associated 2G4
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H17929  EPDNEW_H17931  EPDNEW_H17932  EPDNEW_H17933  EPDNEW_H17934  
Experiment Methods:Single-end sequencing.; Paired-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381256,104,566 - 56,104,626EPDNEW
RGD ID:7224371
Promoter ID:EPDNEW_H17931
Type:initiation region
Name:PA2G4_5
Description:proliferation-associated 2G4
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H17929  EPDNEW_H17930  EPDNEW_H17932  EPDNEW_H17933  EPDNEW_H17934  
Experiment Methods:Single-end sequencing.; Paired-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381256,106,682 - 56,106,742EPDNEW
RGD ID:7224373
Promoter ID:EPDNEW_H17932
Type:initiation region
Name:PA2G4_3
Description:proliferation-associated 2G4
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H17929  EPDNEW_H17930  EPDNEW_H17931  EPDNEW_H17933  EPDNEW_H17934  
Experiment Methods:Single-end sequencing.; Paired-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381256,107,056 - 56,107,116EPDNEW
RGD ID:7224375
Promoter ID:EPDNEW_H17933
Type:initiation region
Name:PA2G4_4
Description:proliferation-associated 2G4
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H17929  EPDNEW_H17930  EPDNEW_H17931  EPDNEW_H17932  EPDNEW_H17934  
Experiment Methods:Single-end sequencing.; Paired-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381256,107,576 - 56,107,636EPDNEW
RGD ID:7224377
Promoter ID:EPDNEW_H17934
Type:initiation region
Name:PA2G4_6
Description:proliferation-associated 2G4
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H17929  EPDNEW_H17930  EPDNEW_H17931  EPDNEW_H17932  EPDNEW_H17933  
Experiment Methods:Single-end sequencing.; Paired-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381256,109,254 - 56,109,314EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:8550 AgrOrtholog
COSMIC PA2G4 COSMIC
Ensembl Genes ENSG00000170515 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENST00000303305 ENTREZGENE
  ENST00000303305.11 UniProtKB/Swiss-Prot
  ENST00000551061.1 UniProtKB/TrEMBL
  ENST00000552766.5 UniProtKB/TrEMBL
  ENST00000553057.5 UniProtKB/TrEMBL
Gene3D-CATH 1.10.10.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.90.230.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000170515 GTEx
HGNC ID HGNC:8550 ENTREZGENE
Human Proteome Map PA2G4 Human Proteome Map
InterPro Creatinase/aminopeptidase-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PA2G4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PA2G4/ARX1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pept_M24 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pept_M24A_MAP2_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WH-like_DNA-bd_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WH_DNA-bd_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:5036 UniProtKB/Swiss-Prot
NCBI Gene 5036 ENTREZGENE
OMIM 602145 OMIM
PANTHER PROLIFERATION-ASSOCIATED PROTEIN 2G4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROLIFERATION-ASSOCIATED PROTEIN 2G4 UniProtKB/TrEMBL
  PROTEASE FAMILY M24 METHIONYL AMINOPEPTIDASE, AMINOPEPTIDASE P UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Peptidase_M24 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA32877 PharmGKB
PROSITE MAP_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF46785 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF55920 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A8K6Y1 ENTREZGENE, UniProtKB/TrEMBL
  F8VR77_HUMAN UniProtKB/TrEMBL
  F8VZ69_HUMAN UniProtKB/TrEMBL
  F8W0A3_HUMAN UniProtKB/TrEMBL
  O43846 ENTREZGENE
  PA2G4_HUMAN UniProtKB/Swiss-Prot
  Q05D08_HUMAN UniProtKB/TrEMBL
  Q6PIN5_HUMAN UniProtKB/TrEMBL
  Q9UM59 ENTREZGENE
  Q9UQ80 ENTREZGENE
UniProt Secondary O43846 UniProtKB/Swiss-Prot
  Q9UM59 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-11-17 PA2G4  proliferation-associated 2G4  PA2G4  proliferation-associated 2G4, 38kDa  Symbol and/or name change 5135510 APPROVED