TARS1 (threonyl-tRNA synthetase 1) - Rat Genome Database

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Gene: TARS1 (threonyl-tRNA synthetase 1) Homo sapiens
Analyze
Symbol: TARS1
Name: threonyl-tRNA synthetase 1
RGD ID: 1347839
HGNC Page HGNC:11572
Description: Enables several functions, including ATP binding activity; threonine-tRNA ligase activity; and zinc ion binding activity. Involved in threonyl-tRNA aminoacylation. Located in extracellular exosome. Implicated in nonphotosensitive trichothiodystrophy 7.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: MGC9344; TARS; threonine tRNA ligase 1, cytoplasmic; threonine--tRNA ligase; threonine--tRNA ligase 1, cytoplasmic; threonine--tRNA ligase, cytoplasmic; threonyl-tRNA synthetase; threonyl-tRNA synthetase, cytoplasmic; ThrRS; TTD7
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38533,440,696 - 33,468,091 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl533,440,696 - 33,468,091 (+)EnsemblGRCh38hg38GRCh38
GRCh37533,440,802 - 33,468,196 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36533,476,655 - 33,503,953 (+)NCBINCBI36hg18NCBI36
Build 34533,476,654 - 33,503,953NCBI
Celera533,321,918 - 33,349,216 (+)NCBI
Cytogenetic Map5p13.3NCBI
HuRef533,409,576 - 33,436,969 (+)NCBIHuRef
CHM1_1533,442,410 - 33,469,806 (+)NCBICHM1_1
T2T-CHM13v2.0533,555,295 - 33,582,692 (+)NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (ISO)
1,2-dimethylhydrazine  (ISO)
1-chloro-2,4-dinitrobenzene  (EXP)
1-nitropyrene  (EXP)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-17-methylestra-4,9,11-trien-3-one  (EXP)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2-amino-14,16-dimethyloctadecan-3-ol  (EXP)
3-chloropropane-1,2-diol  (ISO)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (EXP)
acetamide  (ISO)
acrolein  (EXP)
acrylamide  (EXP)
afimoxifene  (EXP)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (EXP)
alpha-pinene  (EXP)
ampicillin  (ISO)
aristolochic acid  (EXP)
benzo[a]pyrene  (ISO)
bisphenol A  (EXP,ISO)
borrelidin  (EXP)
buspirone  (ISO)
cadmium dichloride  (EXP,ISO)
cannabidiol  (EXP)
carbon nanotube  (ISO)
chloroacetaldehyde  (EXP)
chloropicrin  (EXP)
chromium(6+)  (ISO)
cidofovir anhydrous  (EXP)
cisplatin  (EXP,ISO)
clodronic acid  (EXP)
cocaine  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (EXP)
Cuprizon  (EXP)
cyclosporin A  (EXP)
decabromodiphenyl ether  (EXP)
dibenz[a,h]anthracene  (ISO)
dibutyl phthalate  (ISO)
dicrotophos  (EXP)
dioxygen  (EXP,ISO)
dorsomorphin  (EXP)
doxorubicin  (EXP)
entinostat  (EXP)
enzyme inhibitor  (EXP)
fenofibrate  (ISO)
flutamide  (ISO)
fulvestrant  (EXP)
gentamycin  (ISO)
glafenine  (ISO)
hydrogen peroxide  (EXP)
ifosfamide  (EXP)
indole-3-methanol  (ISO)
L-ascorbic acid  (EXP)
lead diacetate  (ISO)
leflunomide  (EXP)
lithium chloride  (EXP)
mercury dichloride  (ISO)
methylmercury chloride  (EXP)
metronidazole  (ISO)
neomycin  (ISO)
ochratoxin A  (EXP)
oxycodone  (ISO)
ozone  (EXP)
panobinostat  (EXP)
paracetamol  (ISO)
paraquat  (ISO)
parathion  (ISO)
perfluorononanoic acid  (EXP)
perfluorooctanoic acid  (EXP)
phenobarbital  (EXP,ISO)
pirinixic acid  (ISO)
potassium dichromate  (EXP)
raloxifene  (EXP)
resveratrol  (EXP)
rotenone  (ISO)
SB 431542  (EXP)
sirolimus  (ISO)
sodium arsenite  (EXP)
sunitinib  (EXP)
tamoxifen  (ISO)
tetrachloromethane  (ISO)
thapsigargin  (EXP)
thioacetamide  (ISO)
trichostatin A  (EXP)
trimellitic anhydride  (ISO)
tunicamycin  (EXP)
valproic acid  (EXP)
vancomycin  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Human Phenotype
Abnormal pyramidal sign  (IAGP)
Abnormality of prenatal development or birth  (IAGP)
Absence of subcutaneous fat  (IAGP)
Alopecia of scalp  (IAGP)
Anemia  (IAGP)
Aplasia/Hypoplasia of the nails  (IAGP)
Astigmatism  (IAGP)
Autosomal recessive inheritance  (IAGP)
Bilateral microphthalmos  (IAGP)
Bilateral sensorineural hearing impairment  (IAGP)
Bird-like facies  (IAGP)
Brittle hair  (IAGP)
Bronchospasm  (IAGP)
Cardiomyopathy  (IAGP)
Carious teeth  (IAGP)
Cerebral cortical atrophy  (IAGP)
Cerebral dysmyelination  (IAGP)
Clubbing  (IAGP)
Coarse facial features  (IAGP)
Concave nail  (IAGP)
Congenital exfoliative erythroderma  (IAGP)
Congenital nonbullous ichthyosiform erythroderma  (IAGP)
Craniosynostosis  (IAGP)
Cryptorchidism  (IAGP)
Cutaneous photosensitivity  (IAGP)
Defective DNA repair after ultraviolet radiation damage  (IAGP)
Delayed skeletal maturation  (IAGP)
Developmental cataract  (IAGP)
Diffuse cerebellar atrophy  (IAGP)
Dry skin  (IAGP)
Dysarthria  (IAGP)
Dysphonia  (IAGP)
Dystrophic fingernails  (IAGP)
Ectropion  (IAGP)
Eczema  (IAGP)
Enamel hypoplasia  (IAGP)
Epicanthus  (IAGP)
Esotropia  (IAGP)
Follicular hyperkeratosis  (IAGP)
Fragile nails  (IAGP)
Gait ataxia  (IAGP)
Generalized hyperreflexia  (IAGP)
Generalized hypotonia  (IAGP)
Generalized-onset seizure  (IAGP)
Global developmental delay  (IAGP)
Gonadal dysgenesis  (IAGP)
High, narrow palate  (IAGP)
Hypertelorism  (IAGP)
Hypoplasia of mandible relative to maxilla  (IAGP)
Hyporeflexia  (IAGP)
Hypotelorism  (IAGP)
Ichthyosis  (IAGP)
Impaired social reciprocity  (IAGP)
Increased bone mineral density  (IAGP)
Increased mean corpuscular hemoglobin concentration  (IAGP)
Intention tremor  (IAGP)
Intrauterine growth retardation  (IAGP)
Joint dislocation  (IAGP)
Keratoconjunctivitis sicca  (IAGP)
Low-set nipples  (IAGP)
Macular degeneration  (IAGP)
Microcephaly  (IAGP)
Microcornea  (IAGP)
Multiple joint contractures  (IAGP)
Myopia  (IAGP)
Neutropenia  (IAGP)
Numerous pigmented freckles  (IAGP)
Nystagmus  (IAGP)
Osteopenia  (IAGP)
Panhypogammaglobulinemia  (IAGP)
Paraplegia/paraparesis  (IAGP)
Partial agenesis of the corpus callosum  (IAGP)
Peripheral neuropathy  (IAGP)
Periventricular leukomalacia  (IAGP)
Photophobia  (IAGP)
Prematurely aged appearance  (IAGP)
Protruding ear  (IAGP)
Psychomotor retardation  (IAGP)
Recurrent bronchopulmonary infections  (IAGP)
Retrognathia  (IAGP)
Ridged nail  (IAGP)
Sparse scalp hair  (IAGP)
Spasticity  (IAGP)
Split nail  (IAGP)
Squamous cell carcinoma  (IAGP)
Thoracic kyphosis  (IAGP)
Tiger tail banding  (IAGP)
Umbilical hernia  (IAGP)
Ventricular septal defect  (IAGP)
Ventriculomegaly  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. GOAs Human GO annotations GOA_HUMAN data from the GO Consortium
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:2033077   PMID:2747635   PMID:3464105   PMID:7118399   PMID:7118437   PMID:7626230   PMID:8049265   PMID:8125298   PMID:11329013   PMID:12477932   PMID:14702039   PMID:15489334  
PMID:16009940   PMID:16139798   PMID:17203973   PMID:17220478   PMID:17353931   PMID:18029348   PMID:19738201   PMID:20458337   PMID:20562859   PMID:21081666   PMID:21145461   PMID:21319273  
PMID:21873635   PMID:22190034   PMID:22623428   PMID:22863883   PMID:22939629   PMID:22990118   PMID:23375620   PMID:23425968   PMID:24457600   PMID:24711643   PMID:24778252   PMID:24797263  
PMID:25147182   PMID:25163878   PMID:25277244   PMID:25416956   PMID:25824639   PMID:25921289   PMID:25963833   PMID:26344197   PMID:26496610   PMID:26511642   PMID:26831064   PMID:26972000  
PMID:27576135   PMID:27684187   PMID:28302793   PMID:28514442   PMID:28515276   PMID:29053956   PMID:29117863   PMID:29229926   PMID:29328069   PMID:29346117   PMID:29467282   PMID:29507755  
PMID:29564676   PMID:30575818   PMID:30619736   PMID:30737378   PMID:30809309   PMID:30902983   PMID:30948266   PMID:31046837   PMID:31073040   PMID:31091453   PMID:31239290   PMID:31374204  
PMID:31501420   PMID:31519766   PMID:31586073   PMID:31995728   PMID:32129710   PMID:32296183   PMID:32416067   PMID:32529326   PMID:32572027   PMID:32807901   PMID:32814053   PMID:32929329  
PMID:33144569   PMID:33957083   PMID:33961781   PMID:34079125   PMID:34159625   PMID:34373451   PMID:34709727   PMID:34711951   PMID:34795231   PMID:35271311  


Genomics

Comparative Map Data
TARS1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38533,440,696 - 33,468,091 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl533,440,696 - 33,468,091 (+)EnsemblGRCh38hg38GRCh38
GRCh37533,440,802 - 33,468,196 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36533,476,655 - 33,503,953 (+)NCBINCBI36hg18NCBI36
Build 34533,476,654 - 33,503,953NCBI
Celera533,321,918 - 33,349,216 (+)NCBI
Cytogenetic Map5p13.3NCBI
HuRef533,409,576 - 33,436,969 (+)NCBIHuRef
CHM1_1533,442,410 - 33,469,806 (+)NCBICHM1_1
T2T-CHM13v2.0533,555,295 - 33,582,692 (+)NCBI
Tars
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391511,383,749 - 11,399,744 (-)NCBIGRCm39mm39
GRCm39 Ensembl1511,382,387 - 11,399,751 (-)Ensembl
GRCm381511,383,663 - 11,399,658 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1511,382,301 - 11,399,665 (-)EnsemblGRCm38mm10GRCm38
MGSCv371511,313,418 - 11,329,413 (-)NCBIGRCm37mm9NCBIm37
MGSCv361511,328,388 - 11,344,383 (-)NCBImm8
Celera1511,167,393 - 11,183,912 (-)NCBICelera
Cytogenetic Map15A1NCBI
cM Map155.6NCBI
Tars1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2260,368,251 - 60,387,733 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl260,367,796 - 60,387,717 (-)Ensembl
Rnor_6.0261,394,632 - 61,414,115 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl261,394,770 - 61,414,102 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0283,279,708 - 83,299,254 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4260,765,899 - 60,784,665 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1260,694,140 - 60,712,898 (-)NCBI
Celera258,303,445 - 58,322,211 (+)NCBICelera
Cytogenetic Map2q16NCBI
Tars1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542619,087,389 - 19,110,609 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495542619,086,817 - 19,110,609 (+)NCBIChiLan1.0ChiLan1.0
TARS1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1582,258,960 - 82,286,179 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl582,256,706 - 82,286,179 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0576,874,096 - 76,901,208 (-)NCBIMhudiblu_PPA_v0panPan3
TARS1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1474,213,475 - 74,239,056 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl474,213,772 - 74,238,971 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha473,838,693 - 73,864,242 (-)NCBI
ROS_Cfam_1.0474,724,661 - 74,750,271 (-)NCBI
ROS_Cfam_1.0 Ensembl474,724,664 - 74,750,266 (-)Ensembl
UMICH_Zoey_3.1474,470,041 - 74,495,641 (-)NCBI
UNSW_CanFamBas_1.0474,598,119 - 74,623,709 (-)NCBI
UU_Cfam_GSD_1.0475,128,157 - 75,153,735 (-)NCBI
Tars1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213223,835,129 - 223,859,335 (+)NCBI
SpeTri2.0NW_0049365187,512,498 - 7,536,854 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TARS1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1619,455,092 - 19,486,732 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11619,455,294 - 19,486,735 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21620,336,784 - 20,350,362 (+)NCBISscrofa10.2Sscrofa10.2susScr3
TARS1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1432,670,020 - 32,697,608 (+)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl432,670,203 - 32,699,168 (+)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366607122,947,080 - 22,976,025 (+)NCBIVero_WHO_p1.0
Tars1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475921,132,116 - 21,154,620 (-)EnsemblHetGla_female_1.0hetGla2
HetGla 1.0NW_00462475921,132,104 - 21,154,533 (-)NCBIHetGla_female_1.0hetGla2

Position Markers
G62112  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37533,467,838 - 33,467,965UniSTSGRCh37
Build 36533,503,595 - 33,503,722RGDNCBI36
Celera533,348,858 - 33,348,985RGD
Cytogenetic Map5p13.2UniSTS
HuRef533,436,611 - 33,436,738UniSTS
RH35850  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37533,467,944 - 33,468,075UniSTSGRCh37
Build 36533,503,701 - 33,503,832RGDNCBI36
Celera533,348,964 - 33,349,095RGD
Cytogenetic Map5p13.2UniSTS
HuRef533,436,717 - 33,436,848UniSTS
GeneMap99-GB4 RH Map5121.61UniSTS
TARS__5192  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37533,467,672 - 33,468,208UniSTSGRCh37
Build 36533,503,429 - 33,503,965RGDNCBI36
Celera533,348,692 - 33,349,228RGD
HuRef533,436,445 - 33,436,981UniSTS
STS-T80838  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37533,466,365 - 33,466,485UniSTSGRCh37
Build 36533,502,122 - 33,502,242RGDNCBI36
Celera533,347,385 - 33,347,505RGD
Cytogenetic Map5p13.2UniSTS
HuRef533,435,140 - 33,435,260UniSTS
GeneMap99-GB4 RH Map5121.98UniSTS
G19676  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37533,467,864 - 33,468,048UniSTSGRCh37
Build 36533,503,621 - 33,503,805RGDNCBI36
Celera533,348,884 - 33,349,068RGD
Cytogenetic Map5p13.2UniSTS
HuRef533,436,637 - 33,436,821UniSTS
A001V01  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37533,467,864 - 33,468,048UniSTSGRCh37
Build 36533,503,621 - 33,503,805RGDNCBI36
Celera533,348,884 - 33,349,068RGD
Cytogenetic Map5p13.2UniSTS
HuRef533,436,637 - 33,436,821UniSTS
GeneMap99-GB4 RH Map5121.98UniSTS
EST23E6  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37533,455,072 - 33,455,172UniSTSGRCh37
Build 36533,490,829 - 33,490,929RGDNCBI36
Celera533,336,092 - 33,336,192RGD
HuRef533,423,847 - 33,423,947UniSTS

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:4312
Count of miRNA genes:1111
Interacting mature miRNAs:1378
Transcripts:ENST00000265112, ENST00000414361, ENST00000455217, ENST00000502508, ENST00000502553, ENST00000503422, ENST00000504698, ENST00000505012, ENST00000506040, ENST00000507716, ENST00000508361, ENST00000509410, ENST00000509731, ENST00000513066, ENST00000514259, ENST00000541634
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component pharyngeal arch
High
Medium 2378 1979 1642 552 1257 394 3886 1688 2172 357 1410 1606 174 1 1193 2448 6 2
Low 61 1012 84 72 694 71 471 509 1562 62 50 7 1 11 340
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001258437 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001258438 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_152295 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_047676 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_047677 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_047678 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC025441 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC034231 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK095852 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK222804 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK292346 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK293620 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK296783 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK308342 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK311361 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK315713 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AW246273 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC000517 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC003699 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC010578 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC088355 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BF028586 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BG183397 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471118 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068273 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KF510921 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M63180 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000265112   ⟹   ENSP00000265112
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl533,440,965 - 33,468,086 (+)Ensembl
RefSeq Acc Id: ENST00000455217   ⟹   ENSP00000387710
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl533,440,965 - 33,467,838 (+)Ensembl
RefSeq Acc Id: ENST00000502508
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl533,440,805 - 33,446,197 (+)Ensembl
RefSeq Acc Id: ENST00000502553   ⟹   ENSP00000424387
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl533,440,696 - 33,467,933 (+)Ensembl
RefSeq Acc Id: ENST00000503422
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl533,466,758 - 33,468,091 (+)Ensembl
RefSeq Acc Id: ENST00000504698
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl533,456,034 - 33,459,969 (+)Ensembl
RefSeq Acc Id: ENST00000505012   ⟹   ENSP00000422291
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl533,440,995 - 33,455,012 (+)Ensembl
RefSeq Acc Id: ENST00000506040   ⟹   ENSP00000422598
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl533,441,381 - 33,448,730 (+)Ensembl
RefSeq Acc Id: ENST00000507716   ⟹   ENSP00000420893
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl533,440,977 - 33,468,062 (+)Ensembl
RefSeq Acc Id: ENST00000508361   ⟹   ENSP00000427627
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl533,440,964 - 33,468,085 (+)Ensembl
RefSeq Acc Id: ENST00000509410
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl533,461,008 - 33,466,216 (+)Ensembl
RefSeq Acc Id: ENST00000509731   ⟹   ENSP00000427304
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl533,440,993 - 33,466,917 (+)Ensembl
RefSeq Acc Id: ENST00000513066   ⟹   ENSP00000425524
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl533,440,996 - 33,453,366 (+)Ensembl
RefSeq Acc Id: ENST00000514259   ⟹   ENSP00000422130
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl533,440,739 - 33,453,346 (+)Ensembl
RefSeq Acc Id: ENST00000626210   ⟹   ENSP00000486893
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl533,441,087 - 33,446,669 (+)Ensembl
RefSeq Acc Id: ENST00000627006   ⟹   ENSP00000486068
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl533,441,087 - 33,453,321 (+)Ensembl
RefSeq Acc Id: NM_001258437   ⟹   NP_001245366
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38533,440,696 - 33,468,091 (+)NCBI
HuRef533,409,576 - 33,436,969 (+)NCBI
CHM1_1533,442,410 - 33,469,806 (+)NCBI
T2T-CHM13v2.0533,555,295 - 33,582,692 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001258438   ⟹   NP_001245367
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38533,440,965 - 33,468,086 (+)NCBI
GRCh37533,440,802 - 33,468,196 (+)NCBI
HuRef533,409,576 - 33,436,969 (+)NCBI
CHM1_1533,442,490 - 33,469,806 (+)NCBI
T2T-CHM13v2.0533,555,564 - 33,582,687 (+)NCBI
Sequence:
RefSeq Acc Id: NM_152295   ⟹   NP_689508
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38533,440,965 - 33,468,086 (+)NCBI
GRCh37533,440,802 - 33,468,196 (+)NCBI
Build 36533,476,655 - 33,503,953 (+)NCBI Archive
HuRef533,409,576 - 33,436,969 (+)NCBI
CHM1_1533,442,490 - 33,469,806 (+)NCBI
T2T-CHM13v2.0533,555,564 - 33,582,687 (+)NCBI
Sequence:
RefSeq Acc Id: NR_047676
RefSeq Status: REVIEWED
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38533,440,965 - 33,468,086 (+)NCBI
GRCh37533,440,802 - 33,468,196 (+)NCBI
HuRef533,409,576 - 33,436,969 (+)NCBI
CHM1_1533,442,490 - 33,469,806 (+)NCBI
T2T-CHM13v2.0533,555,564 - 33,582,687 (+)NCBI
Sequence:
RefSeq Acc Id: NR_047677
RefSeq Status: REVIEWED
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38533,440,965 - 33,468,086 (+)NCBI
GRCh37533,440,802 - 33,468,196 (+)NCBI
HuRef533,409,576 - 33,436,969 (+)NCBI
CHM1_1533,442,490 - 33,469,806 (+)NCBI
T2T-CHM13v2.0533,555,564 - 33,582,687 (+)NCBI
Sequence:
RefSeq Acc Id: NR_047678
RefSeq Status: REVIEWED
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38533,440,965 - 33,468,086 (+)NCBI
GRCh37533,440,802 - 33,468,196 (+)NCBI
HuRef533,409,576 - 33,436,969 (+)NCBI
CHM1_1533,442,490 - 33,469,806 (+)NCBI
T2T-CHM13v2.0533,555,564 - 33,582,687 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_689508   ⟸   NM_152295
- Peptide Label: isoform 1
- UniProtKB: P26639 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001245366   ⟸   NM_001258437
- Peptide Label: isoform 1
- UniProtKB: P26639 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001245367   ⟸   NM_001258438
- Peptide Label: isoform 2
- UniProtKB: P26639 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSP00000424387   ⟸   ENST00000502553
RefSeq Acc Id: ENSP00000422291   ⟸   ENST00000505012
RefSeq Acc Id: ENSP00000422598   ⟸   ENST00000506040
RefSeq Acc Id: ENSP00000420893   ⟸   ENST00000507716
RefSeq Acc Id: ENSP00000427627   ⟸   ENST00000508361
RefSeq Acc Id: ENSP00000387710   ⟸   ENST00000455217
RefSeq Acc Id: ENSP00000486893   ⟸   ENST00000626210
RefSeq Acc Id: ENSP00000486068   ⟸   ENST00000627006
RefSeq Acc Id: ENSP00000427304   ⟸   ENST00000509731
RefSeq Acc Id: ENSP00000425524   ⟸   ENST00000513066
RefSeq Acc Id: ENSP00000422130   ⟸   ENST00000514259
RefSeq Acc Id: ENSP00000265112   ⟸   ENST00000265112
Protein Domains
TGS

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P26639-F1-model_v2 AlphaFold P26639 1-723 view protein structure

Promoters
RGD ID:6869334
Promoter ID:EPDNEW_H7832
Type:initiation region
Name:TARS_1
Description:threonyl-tRNA synthetase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh38533,440,993 - 33,441,053EPDNEW
RGD ID:6803592
Promoter ID:HG_KWN:49919
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   CD4+TCell_2Hour,   HeLa_S3,   Jurkat,   K562,   Lymphoblastoid,   NB4
Transcripts:OTTHUMT00000207367,   UC003JHZ.1,   UC010IUP.1
Position:
Human AssemblyChrPosition (strand)Source
Build 36533,475,886 - 33,477,062 (+)MPROMDB
RGD ID:6851752
Promoter ID:EP73623
Type:initiation region
Name:HS_TARS
Description:Threonyl-tRNA synthetase.
SO ACC ID:SO:0000170
Source:EPD (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:NEDO full length human cDNA sequencing project.; Oligo-capping
Position:
Human AssemblyChrPosition (strand)Source
Build 36533,476,856 - 33,476,916EPD

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 5p15.33-13.2(chr5:54839-35680845)x3 copy number gain See cases [RCV000051811] Chr5:54839..35680845 [GRCh38]
Chr5:54954..35680947 [GRCh37]
Chr5:107954..35716704 [NCBI36]
Chr5:5p15.33-13.2
pathogenic
GRCh38/hg38 5p14.1-q11.1(chr5:26593632-50288555)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000051834]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000051834]|See cases [RCV000051834] Chr5:26593632..50288555 [GRCh38]
Chr5:26593741..49584389 [GRCh37]
Chr5:26629498..49620146 [NCBI36]
Chr5:5p14.1-q11.1
pathogenic
GRCh38/hg38 5p15.33-12(chr5:54839-45649861)x3 copy number gain See cases [RCV000051810] Chr5:54839..45649861 [GRCh38]
Chr5:54954..45649963 [GRCh37]
Chr5:107954..45685720 [NCBI36]
Chr5:5p15.33-12
pathogenic
GRCh38/hg38 5p13.3-13.2(chr5:30149035-35213678)x1 copy number loss See cases [RCV000053449] Chr5:30149035..35213678 [GRCh38]
Chr5:30149142..35213780 [GRCh37]
Chr5:30184899..35249537 [NCBI36]
Chr5:5p13.3-13.2
pathogenic
GRCh38/hg38 5p13.3-13.2(chr5:30961310-36143306)x1 copy number loss See cases [RCV000135667] Chr5:30961310..36143306 [GRCh38]
Chr5:30961417..36143408 [GRCh37]
Chr5:30997174..36179165 [NCBI36]
Chr5:5p13.3-13.2
likely pathogenic
GRCh38/hg38 5p15.33-11(chr5:49978-46114984)x3 copy number gain See cases [RCV000135453] Chr5:49978..46114984 [GRCh38]
Chr5:50093..46115086 [GRCh37]
Chr5:103093..46150843 [NCBI36]
Chr5:5p15.33-11
pathogenic
GRCh38/hg38 5p15.33-13.2(chr5:22149-35831538)x1 copy number loss See cases [RCV000138888] Chr5:22149..35831538 [GRCh38]
Chr5:22149..35831640 [GRCh37]
Chr5:75149..35867397 [NCBI36]
Chr5:5p15.33-13.2
pathogenic
GRCh38/hg38 5p15.32-13.2(chr5:4849498-36818719)x3 copy number gain See cases [RCV000141246] Chr5:4849498..36818719 [GRCh38]
Chr5:4849611..36818821 [GRCh37]
Chr5:4902611..36854578 [NCBI36]
Chr5:5p15.32-13.2
pathogenic
GRCh38/hg38 5p15.33-13.2(chr5:113461-33998289)x1 copy number loss See cases [RCV000141844] Chr5:113461..33998289 [GRCh38]
Chr5:113576..33998394 [GRCh37]
Chr5:166576..34034151 [NCBI36]
Chr5:5p15.33-13.2
pathogenic
GRCh37/hg19 5p15.2-12(chr5:13461664-46098927)x3 copy number gain See cases [RCV000239779] Chr5:13461664..46098927 [GRCh37]
Chr5:5p15.2-12
pathogenic
GRCh38/hg38 5p15.33-q13.3(chr5:22149-74412725)x3 copy number gain See cases [RCV000138780] Chr5:22149..74412725 [GRCh38]
Chr5:22149..73708550 [GRCh37]
Chr5:75149..73744306 [NCBI36]
Chr5:5p15.33-q13.3
pathogenic
GRCh37/hg19 5p15.33-13.3(chr5:113576-33493797)x1 copy number loss See cases [RCV000449075] Chr5:113576..33493797 [GRCh37]
Chr5:5p15.33-13.3
pathogenic
GRCh37/hg19 5p15.33-13.2(chr5:22149-34041255)x3 copy number gain See cases [RCV000240016] Chr5:22149..34041255 [GRCh37]
Chr5:5p15.33-13.2
pathogenic
GRCh37/hg19 5p15.33-13.2(chr5:113576-34372083)x1 copy number loss See cases [RCV000446974] Chr5:113576..34372083 [GRCh37]
Chr5:5p15.33-13.2
pathogenic
GRCh37/hg19 5p15.33-13.2(chr5:22149-34041196)x1 copy number loss See cases [RCV000448019] Chr5:22149..34041196 [GRCh37]
Chr5:5p15.33-13.2
pathogenic
GRCh37/hg19 5p15.1-q35.2(chr5:17628741-176575720)x1 copy number loss See cases [RCV000511978] Chr5:17628741..176575720 [GRCh37]
Chr5:5p15.1-q35.2
pathogenic
GRCh37/hg19 5p15.33-q35.3(chr5:113577-180719789)x3 copy number gain See cases [RCV000512039] Chr5:113577..180719789 [GRCh37]
Chr5:5p15.33-q35.3
pathogenic
GRCh37/hg19 5p14.2-11(chr5:24281195-46389339)x3 copy number gain See cases [RCV000512120] Chr5:24281195..46389339 [GRCh37]
Chr5:5p14.2-11
likely pathogenic
GRCh37/hg19 5p15.33-q35.3(chr5:113577-180719789) copy number gain See cases [RCV000510723] Chr5:113577..180719789 [GRCh37]
Chr5:5p15.33-q35.3
pathogenic
GRCh37/hg19 5p15.33-13.2(chr5:113576-35739404)x3 copy number gain not provided [RCV000682516] Chr5:113576..35739404 [GRCh37]
Chr5:5p15.33-13.2
pathogenic
GRCh37/hg19 5p14.1-12(chr5:27227243-45685844)x3 copy number gain not provided [RCV000682542] Chr5:27227243..45685844 [GRCh37]
Chr5:5p14.1-12
pathogenic
GRCh37/hg19 5p13.3(chr5:32427829-33458399)x3 copy number gain not provided [RCV000682544] Chr5:32427829..33458399 [GRCh37]
Chr5:5p13.3
uncertain significance
NM_152295.5(TARS1):c.826A>G (p.Lys276Glu) single nucleotide variant Trichothiodystrophy 7, nonphotosensitive [RCV000850112] Chr5:33456216 [GRCh38]
Chr5:33456321 [GRCh37]
Chr5:5p13.3
pathogenic
NM_152295.5(TARS1):c.680T>C (p.Leu227Pro) single nucleotide variant Trichothiodystrophy 7, nonphotosensitive [RCV000850113] Chr5:33455691 [GRCh38]
Chr5:33455796 [GRCh37]
Chr5:5p13.3
pathogenic
GRCh37/hg19 5p15.33-q35.3(chr5:25328-180693344)x3 copy number gain not provided [RCV000744323] Chr5:25328..180693344 [GRCh37]
Chr5:5p15.33-q35.3
pathogenic
GRCh37/hg19 5p15.33-q35.3(chr5:13648-180905029)x3 copy number gain not provided [RCV000744317] Chr5:13648..180905029 [GRCh37]
Chr5:5p15.33-q35.3
pathogenic
NM_152295.5(TARS1):c.62G>A (p.Gly21Asp) single nucleotide variant not provided [RCV000963842] Chr5:33445328 [GRCh38]
Chr5:33445434 [GRCh37]
Chr5:5p13.3
benign
NM_152295.5(TARS1):c.231A>C (p.Glu77Asp) single nucleotide variant not provided [RCV000950677] Chr5:33448633 [GRCh38]
Chr5:33448739 [GRCh37]
Chr5:5p13.3
benign
NM_152295.5(TARS1):c.525C>T (p.Tyr175=) single nucleotide variant not provided [RCV000950678] Chr5:33455016 [GRCh38]
Chr5:33455121 [GRCh37]
Chr5:5p13.3
benign
NM_152295.5(TARS1):c.1739G>A (p.Gly580Asp) single nucleotide variant not provided [RCV000948291] Chr5:33462107 [GRCh38]
Chr5:33462212 [GRCh37]
Chr5:5p13.3
benign
GRCh37/hg19 5p13.3-13.2(chr5:29720391-34124081)x1 copy number loss not provided [RCV001005668] Chr5:29720391..34124081 [GRCh37]
Chr5:5p13.3-13.2
uncertain significance
NM_152295.5(TARS1):c.352G>A (p.Val118Ile) single nucleotide variant not provided [RCV000889531] Chr5:33453311 [GRCh38]
Chr5:33453416 [GRCh37]
Chr5:5p13.3
benign
NM_152295.5(TARS1):c.985-35G>A single nucleotide variant Trichothiodystrophy 7, nonphotosensitive [RCV001815647] Chr5:33458531 [GRCh38]
Chr5:33458636 [GRCh37]
Chr5:5p13.3
benign
NM_152295.5(TARS1):c.984+27T>A single nucleotide variant Trichothiodystrophy 7, nonphotosensitive [RCV001816032] Chr5:33457430 [GRCh38]
Chr5:33457535 [GRCh37]
Chr5:5p13.3
benign
NM_152295.5(TARS1):c.1653G>A (p.Ala551=) single nucleotide variant Trichothiodystrophy 7, nonphotosensitive [RCV001816033] Chr5:33461929 [GRCh38]
Chr5:33462034 [GRCh37]
Chr5:5p13.3
benign
GRCh37/hg19 5p14.1-11(chr5:26382110-46389339) copy number gain not specified [RCV002053485] Chr5:26382110..46389339 [GRCh37]
Chr5:5p14.1-11
pathogenic
GRCh37/hg19 5p13.3-12(chr5:29081195-45294031)x3 copy number gain See cases [RCV001310288] Chr5:29081195..45294031 [GRCh37]
Chr5:5p13.3-12
pathogenic
GRCh37/hg19 5p13.3-12(chr5:31351588-43480111)x3 copy number gain not provided [RCV000744593] Chr5:31351588..43480111 [GRCh37]
Chr5:5p13.3-12
pathogenic
Single allele deletion Neurodevelopmental disorder [RCV000787436] Chr5:14685137..149511942 [GRCh37]
Chr5:5p15.2-q32
uncertain significance
NM_152295.5(TARS1):c.1912C>T (p.Arg638Ter) single nucleotide variant Trichothiodystrophy 7, nonphotosensitive [RCV000850111] Chr5:33466874 [GRCh38]
Chr5:33466979 [GRCh37]
Chr5:5p13.3
pathogenic
GRCh37/hg19 5p13.3(chr5:33318611-33493797)x1 copy number loss not provided [RCV001258682] Chr5:33318611..33493797 [GRCh37]
Chr5:5p13.3
uncertain significance
GRCh37/hg19 5p13.3(chr5:33255507-33768313)x3 copy number gain not provided [RCV001258681] Chr5:33255507..33768313 [GRCh37]
Chr5:5p13.3
likely benign

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:11572 AgrOrtholog
COSMIC TARS1 COSMIC
Ensembl Genes ENSG00000113407 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSP00000265112 ENTREZGENE
  ENSP00000265112.3 UniProtKB/Swiss-Prot
  ENSP00000387710 ENTREZGENE
  ENSP00000387710.2 UniProtKB/Swiss-Prot
  ENSP00000420893.1 UniProtKB/TrEMBL
  ENSP00000422130.1 UniProtKB/TrEMBL
  ENSP00000422291.1 UniProtKB/TrEMBL
  ENSP00000422598.1 UniProtKB/TrEMBL
  ENSP00000424387 ENTREZGENE
  ENSP00000424387.1 UniProtKB/Swiss-Prot
  ENSP00000425524.1 UniProtKB/TrEMBL
  ENSP00000427304.1 UniProtKB/TrEMBL
  ENSP00000427627.1 UniProtKB/TrEMBL
  ENSP00000486068.1 UniProtKB/TrEMBL
  ENSP00000486893.1 UniProtKB/TrEMBL
Ensembl Transcript ENST00000265112 ENTREZGENE
  ENST00000265112.8 UniProtKB/Swiss-Prot
  ENST00000455217 ENTREZGENE
  ENST00000455217.6 UniProtKB/Swiss-Prot
  ENST00000502553 ENTREZGENE
  ENST00000502553.5 UniProtKB/Swiss-Prot
  ENST00000505012.5 UniProtKB/TrEMBL
  ENST00000506040.1 UniProtKB/TrEMBL
  ENST00000507716 ENTREZGENE
  ENST00000507716.5 UniProtKB/TrEMBL
  ENST00000508361 ENTREZGENE
  ENST00000508361.5 UniProtKB/TrEMBL
  ENST00000509731.5 UniProtKB/TrEMBL
  ENST00000513066.3 UniProtKB/TrEMBL
  ENST00000514259.5 UniProtKB/TrEMBL
  ENST00000626210.1 UniProtKB/TrEMBL
  ENST00000627006.2 UniProtKB/TrEMBL
Gene3D-CATH 3.10.20.30 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.30.930.10 UniProtKB/Swiss-Prot
  3.40.50.800 UniProtKB/Swiss-Prot
GTEx ENSG00000113407 GTEx
HGNC ID HGNC:11572 ENTREZGENE
Human Proteome Map TARS1 Human Proteome Map
InterPro aa-tRNA-synt_IIb UniProtKB/Swiss-Prot
  aa-tRNA-synth_II UniProtKB/Swiss-Prot
  aa-tRNA-synth_II/BPL/LPL UniProtKB/Swiss-Prot
  Anticodon-bd UniProtKB/Swiss-Prot
  Anticodon-bd_dom_sf UniProtKB/Swiss-Prot
  Beta-grasp_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TGS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TGS-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Thr-tRNA-ligase_IIa UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Thr/Ala-tRNA-synth_IIc_edit UniProtKB/Swiss-Prot
  ThrRS_core UniProtKB/Swiss-Prot
  tRNA_SAD UniProtKB/Swiss-Prot
KEGG Report hsa:6897 UniProtKB/Swiss-Prot
NCBI Gene 6897 ENTREZGENE
OMIM 187790 OMIM
  618546 OMIM
PANTHER PTHR11451 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam HGTP_anticodon UniProtKB/Swiss-Prot
  TGS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  tRNA-synt_2b UniProtKB/Swiss-Prot
  tRNA_SAD UniProtKB/Swiss-Prot
PharmGKB PA36337 PharmGKB
PRINTS TRNASYNTHTHR UniProtKB/Swiss-Prot
PROSITE AA_TRNA_LIGASE_II UniProtKB/Swiss-Prot
  TGS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART tRNA_SAD UniProtKB/Swiss-Prot
Superfamily-SCOP SSF55186 UniProtKB/Swiss-Prot
  SSF55681 UniProtKB/Swiss-Prot
  SSF81271 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGRFAMs thrS UniProtKB/Swiss-Prot
UniProt D6R9F8_HUMAN UniProtKB/TrEMBL
  D6RBR8_HUMAN UniProtKB/TrEMBL
  D6RCA5_HUMAN UniProtKB/TrEMBL
  D6RCS6_HUMAN UniProtKB/TrEMBL
  D6RDJ6_HUMAN UniProtKB/TrEMBL
  D6RHV7_HUMAN UniProtKB/TrEMBL
  D6RJ97_HUMAN UniProtKB/TrEMBL
  P26639 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary A8K8I1 UniProtKB/Swiss-Prot
  B4DEG8 UniProtKB/Swiss-Prot
  Q96FP5 UniProtKB/Swiss-Prot
  Q9BWA6 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-07-23 TARS1  threonyl-tRNA synthetase 1  TARS  threonyl-tRNA synthetase  Symbol and/or name change 5135510 APPROVED