PABPC1 (poly(A) binding protein cytoplasmic 1) - Rat Genome Database

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Gene: PABPC1 (poly(A) binding protein cytoplasmic 1) Homo sapiens
Analyze
Symbol: PABPC1
Name: poly(A) binding protein cytoplasmic 1
RGD ID: 1349848
HGNC Page HGNC
Description: Exhibits RNA binding activity and protein C-terminus binding activity. Involved in negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay and positive regulation of viral genome replication. Localizes to several cellular components, including catalytic step 2 spliceosome; cell leading edge; and cytoplasmic stress granule.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: PAB1; PABP; PABP-1; PABP1; PABPC2; PABPL1; poly(A) binding protein, cytoplasmic 1; poly(A) binding protein, cytoplasmic 2; poly(A)-binding protein 1; polyadenylate-binding protein 1
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Related Pseudogenes: PABPC1P1   PABPC1P10   PABPC1P11   PABPC1P12   PABPC1P13   PABPC1P2   PABPC1P3   PABPC1P4   PABPC1P5   PABPC1P6   PABPC1P7   PABPC1P8   PABPC1P9  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl8100,685,816 - 100,722,809 (-)EnsemblGRCh38hg38GRCh38
GRCh388100,702,916 - 100,722,088 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh378101,715,144 - 101,734,316 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 368101,784,320 - 101,803,491 (-)NCBINCBI36hg18NCBI36
Build 348101,784,319 - 101,803,491NCBI
Celera897,900,528 - 97,919,706 (-)NCBI
Cytogenetic Map8q22.3NCBI
HuRef896,913,861 - 96,933,038 (-)NCBIHuRef
CHM1_18101,755,929 - 101,775,103 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (EXP)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-hydroxy-17-methylestra-4,9,11-trien-3-one  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,4-dinitrotoluene  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-chloropropane-1,2-diol  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (EXP)
4,4'-sulfonyldiphenol  (EXP)
4-hydroxyphenyl retinamide  (ISO)
4-vinylcyclohexene dioxide  (ISO)
7,12-dimethyltetraphene  (ISO)
aconitine  (ISO)
acrolein  (EXP)
alpha-pinene  (EXP)
amino acid  (EXP,ISO)
aristolochic acid  (ISO)
Aroclor 1254  (ISO)
arsane  (EXP)
arsenic atom  (EXP)
benzo[a]pyrene  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP)
bleomycin A2  (ISO)
carbon nanotube  (ISO)
chloropicrin  (EXP)
chloroprene  (ISO)
choline  (ISO)
cisplatin  (EXP,ISO)
clobetasol  (ISO)
clofibric acid  (ISO)
cocaine  (ISO)
cyclosporin A  (ISO)
dexamethasone  (EXP)
dibutyl phthalate  (ISO)
disodium selenite  (EXP)
doxorubicin  (EXP)
enzyme inhibitor  (EXP)
ethanol  (ISO)
etoposide  (ISO)
flavonoids  (ISO)
folic acid  (ISO)
gentamycin  (ISO)
indometacin  (EXP)
isoflavones  (ISO)
L-methionine  (ISO)
lead(0)  (EXP)
lead(2+)  (EXP)
menadione  (EXP)
methoxychlor  (ISO)
N-nitrosodiethylamine  (ISO)
ozone  (EXP)
paracetamol  (ISO)
perfluorooctanoic acid  (ISO)
potassium chromate  (EXP)
pregnenolone 16alpha-carbonitrile  (ISO)
silicon dioxide  (ISO)
sirolimus  (EXP)
sodium arsenate  (ISO)
sodium arsenite  (EXP)
Soman  (ISO)
sunitinib  (EXP)
tetrachloromethane  (ISO)
torin 1  (EXP)
tungsten  (ISO)
valproic acid  (EXP,ISO)
vitamin E  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

Additional References at PubMed
PMID:2885805   PMID:7908267   PMID:8057425   PMID:8657127   PMID:9548260   PMID:9582337   PMID:9857202   PMID:9880551   PMID:10205060   PMID:10358005   PMID:10373504   PMID:10499800  
PMID:10543404   PMID:11051545   PMID:11172725   PMID:11274152   PMID:11287654   PMID:11328870   PMID:11438674   PMID:11591653   PMID:11704675   PMID:11850402   PMID:11991638   PMID:11997512  
PMID:12086624   PMID:12388589   PMID:12477932   PMID:12489690   PMID:12565831   PMID:12588972   PMID:12723973   PMID:12844354   PMID:14559993   PMID:14583602   PMID:14685257   PMID:14702039  
PMID:14739600   PMID:14744259   PMID:15082755   PMID:15121898   PMID:15303970   PMID:15314026   PMID:15324660   PMID:15489334   PMID:15567442   PMID:15592455   PMID:15630022   PMID:15663938  
PMID:15782174   PMID:15831480   PMID:16055720   PMID:16126846   PMID:16293633   PMID:16332685   PMID:16356927   PMID:16452507   PMID:16465428   PMID:16522924   PMID:16556936   PMID:16594896  
PMID:16601676   PMID:16703665   PMID:16716377   PMID:16772376   PMID:16782705   PMID:16804161   PMID:16869712   PMID:16902409   PMID:17150895   PMID:17212783   PMID:17220478   PMID:17267499  
PMID:17289661   PMID:17353931   PMID:17392519   PMID:17595167   PMID:17620599   PMID:17643375   PMID:17785442   PMID:17932509   PMID:18029348   PMID:18056425   PMID:18230761   PMID:18256688  
PMID:18305028   PMID:18321554   PMID:18447585   PMID:18467502   PMID:18596238   PMID:18632855   PMID:18642007   PMID:18729074   PMID:18779327   PMID:18799579   PMID:18957126   PMID:19135240  
PMID:19193790   PMID:19322201   PMID:19369421   PMID:19417104   PMID:19454010   PMID:19515850   PMID:19531213   PMID:19542561   PMID:19716330   PMID:19738201   PMID:19805454   PMID:19934229  
PMID:19946888   PMID:19956697   PMID:20000738   PMID:20009508   PMID:20020773   PMID:20085707   PMID:20096703   PMID:20098421   PMID:20181956   PMID:20221403   PMID:20360068   PMID:20371770  
PMID:20418951   PMID:20430826   PMID:20544796   PMID:20573819   PMID:20595389   PMID:20595394   PMID:20696395   PMID:20890123   PMID:20930030   PMID:20980505   PMID:21063388   PMID:21078877  
PMID:21081503   PMID:21081666   PMID:21098120   PMID:21145460   PMID:21145461   PMID:21182205   PMID:21423176   PMID:21521633   PMID:21539808   PMID:21642987   PMID:21873635   PMID:21883093  
PMID:21940797   PMID:21981923   PMID:21984184   PMID:21984185   PMID:21984414   PMID:21989405   PMID:22004688   PMID:22022268   PMID:22174317   PMID:22268729   PMID:22365833   PMID:22431630  
PMID:22446626   PMID:22586326   PMID:22623428   PMID:22658674   PMID:22681889   PMID:22751105   PMID:22837200   PMID:22863883   PMID:22872150   PMID:22907758   PMID:22939629   PMID:23041282  
PMID:23077296   PMID:23125361   PMID:23125841   PMID:23151878   PMID:23172285   PMID:23230274   PMID:23246001   PMID:23279204   PMID:23340509   PMID:23398456   PMID:23443559   PMID:23463506  
PMID:23533145   PMID:23535375   PMID:23602568   PMID:23665581   PMID:23711718   PMID:23741361   PMID:23770097   PMID:23788676   PMID:23805307   PMID:23824909   PMID:23964095   PMID:23966414  
PMID:24189637   PMID:24332808   PMID:24336168   PMID:24396066   PMID:24532714   PMID:24550385   PMID:24625528   PMID:24711643   PMID:24965446   PMID:25065644   PMID:25111021   PMID:25144556  
PMID:25225333   PMID:25263594   PMID:25266661   PMID:25324306   PMID:25437307   PMID:25496916   PMID:25503397   PMID:25515538   PMID:25665578   PMID:25670202   PMID:25756610   PMID:25921289  
PMID:25940091   PMID:25959826   PMID:25963833   PMID:26097561   PMID:26176602   PMID:26188282   PMID:26209609   PMID:26217791   PMID:26265008   PMID:26269332   PMID:26344197   PMID:26460568  
PMID:26496610   PMID:26527279   PMID:26618866   PMID:26641092   PMID:26673895   PMID:26735137   PMID:26816005   PMID:26831064   PMID:26843391   PMID:26912148   PMID:26936655   PMID:26979993  
PMID:27022092   PMID:27025967   PMID:27158335   PMID:27381497   PMID:27418677   PMID:27503909   PMID:27545878   PMID:27573237   PMID:27591049   PMID:27609421   PMID:27684187   PMID:27871484  
PMID:27976729   PMID:28302793   PMID:28443643   PMID:28514442   PMID:28515276   PMID:28533407   PMID:28611064   PMID:28653618   PMID:28733330   PMID:28756945   PMID:28757607   PMID:28877994  
PMID:28900035   PMID:28902428   PMID:28931820   PMID:28977666   PMID:28982131   PMID:28986522   PMID:29117863   PMID:29128334   PMID:29142127   PMID:29162697   PMID:29228324   PMID:29229926  
PMID:29331416   PMID:29362417   PMID:29395067   PMID:29449217   PMID:29467282   PMID:29507755   PMID:29511261   PMID:29511296   PMID:29567855   PMID:29669786   PMID:29735542   PMID:29777862  
PMID:29782795   PMID:29791485   PMID:29802200   PMID:29845934   PMID:29872149   PMID:29884807   PMID:30021884   PMID:30063126   PMID:30196744   PMID:30320910   PMID:30320934   PMID:30344098  
PMID:30349055   PMID:30367120   PMID:30442662   PMID:30463901   PMID:30575818   PMID:30629181   PMID:30711629   PMID:30737378   PMID:30809309   PMID:30820564   PMID:30890647   PMID:30940648  
PMID:30948266   PMID:30997501   PMID:31010829   PMID:31048545   PMID:31059266   PMID:31091453   PMID:31104843   PMID:31114027   PMID:31180492   PMID:31239290   PMID:31253590   PMID:31300519  
PMID:31365120   PMID:31501420   PMID:31586073   PMID:31640799   PMID:31751430   PMID:31797689   PMID:31980649   PMID:31995728   PMID:32015336   PMID:32041737   PMID:32129710   PMID:32353859  
PMID:32529326   PMID:32780723   PMID:32788342   PMID:32811821   PMID:32814053   PMID:32960270   PMID:33060197   PMID:33080414   PMID:33172261   PMID:33332560  


Genomics

Comparative Map Data
PABPC1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl8100,685,816 - 100,722,809 (-)EnsemblGRCh38hg38GRCh38
GRCh388100,702,916 - 100,722,088 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh378101,715,144 - 101,734,316 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 368101,784,320 - 101,803,491 (-)NCBINCBI36hg18NCBI36
Build 348101,784,319 - 101,803,491NCBI
Celera897,900,528 - 97,919,706 (-)NCBI
Cytogenetic Map8q22.3NCBI
HuRef896,913,861 - 96,933,038 (-)NCBIHuRef
CHM1_18101,755,929 - 101,775,103 (-)NCBICHM1_1
Pabpc1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391536,595,902 - 36,609,825 (-)NCBIGRCm39mm39
GRCm39 Ensembl1536,595,905 - 36,609,912 (-)Ensembl
GRCm381536,595,658 - 36,609,581 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1536,595,661 - 36,609,668 (-)EnsemblGRCm38mm10GRCm38
MGSCv371536,525,413 - 36,538,728 (-)NCBIGRCm37mm9NCBIm37
MGSCv361536,540,252 - 36,553,551 (-)NCBImm8
Celera1537,216,852 - 37,230,173 (-)NCBICelera
Cytogenetic Map15B3.1NCBI
Pabpc1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2767,777,438 - 67,789,731 (-)NCBI
Rnor_6.0 Ensembl775,409,581 - 75,422,268 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0775,409,581 - 75,421,874 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0775,557,634 - 75,569,927 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4772,116,140 - 72,128,433 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1772,136,510 - 72,149,407 (-)NCBI
Celera764,857,404 - 64,869,695 (-)NCBICelera
Cytogenetic Map7q22NCBI
Pabpc1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541715,868,934 - 15,885,247 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541715,872,906 - 15,885,246 (-)NCBIChiLan1.0ChiLan1.0
PABPC1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1899,518,347 - 99,534,284 (-)NCBIpanpan1.1PanPan1.1panPan2
Mhudiblu_PPA_v0897,346,433 - 97,365,628 (-)NCBIMhudiblu_PPA_v0panPan3
PABPC1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1132,563,698 - 2,580,610 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl132,564,065 - 2,580,368 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha132,560,662 - 2,577,627 (-)NCBI
ROS_Cfam_1.0132,717,070 - 2,734,072 (-)NCBI
UMICH_Zoey_3.1132,561,235 - 2,578,211 (-)NCBI
UNSW_CanFamBas_1.0132,672,912 - 2,689,894 (-)NCBI
UU_Cfam_GSD_1.0132,690,335 - 2,707,304 (-)NCBI
Pabpc1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530335,202,647 - 35,244,212 (+)NCBI
SpeTri2.0NW_00493647042,628,890 - 42,670,311 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PABPC1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl436,137,639 - 36,227,690 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1436,137,644 - 36,228,075 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2439,133,409 - 39,152,542 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PABPC1
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1895,560,551 - 95,578,627 (-)NCBI
ChlSab1.1 Ensembl895,561,930 - 95,578,633 (-)Ensembl
Pabpc1
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247637,552,541 - 7,568,047 (-)NCBI

Position Markers
RH68348  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh378101,731,709 - 101,731,858UniSTSGRCh37
Build 368101,800,885 - 101,801,034RGDNCBI36
Celera897,917,100 - 97,917,249RGD
Cytogenetic Map8q22.2-q23UniSTS
HuRef896,930,432 - 96,930,581UniSTS
GeneMap99-GB4 RH Map8439.42UniSTS
NCBI RH Map81107.9UniSTS
G49185  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh378101,718,974 - 101,719,197UniSTSGRCh37
Build 368101,788,150 - 101,788,373RGDNCBI36
Celera897,904,358 - 97,904,581RGD
Cytogenetic Map8q22.2-q23UniSTS
HuRef896,917,688 - 96,917,911UniSTS
GDB:568589  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh378101,715,235 - 101,715,457UniSTSGRCh37
Build 368101,784,411 - 101,784,633RGDNCBI36
Celera897,900,619 - 97,900,841RGD
Cytogenetic Map8q22.2-q23UniSTS
HuRef896,913,952 - 96,914,174UniSTS
STS-R77214  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh378101,715,766 - 101,715,957UniSTSGRCh37
Build 368101,784,942 - 101,785,133RGDNCBI36
Celera897,901,150 - 97,901,341RGD
Cytogenetic Map8q22.2-q23UniSTS
HuRef896,914,483 - 96,914,674UniSTS
GeneMap99-GB4 RH Map8439.22UniSTS
NCBI RH Map81107.9UniSTS
SHGC-30876  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371325,670,908 - 25,671,014UniSTSGRCh37
Build 361324,568,908 - 24,569,014RGDNCBI36
Celera136,734,464 - 6,734,570RGD
Cytogenetic Map8q22.2-q23UniSTS
Cytogenetic Map13q12-q13UniSTS
HuRef136,484,480 - 6,484,586UniSTS
MARC_1283-1284:991931128:1  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh378101,724,622 - 101,724,974UniSTSGRCh37
Build 368101,793,798 - 101,794,150RGDNCBI36
Celera897,910,010 - 97,910,362RGD
HuRef896,923,340 - 96,923,692UniSTS
UniSTS:265534   No map positions available.
D13S1095E  
Human AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic MapXq13-q21UniSTS
Cytogenetic Map8q22.2-q23UniSTS
Cytogenetic Map13q12-q13UniSTS

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:3121
Count of miRNA genes:1070
Interacting mature miRNAs:1331
Transcripts:ENST00000318607, ENST00000517403, ENST00000517921, ENST00000517990, ENST00000518196, ENST00000518293, ENST00000518716, ENST00000519004, ENST00000519100, ENST00000519363, ENST00000519596, ENST00000519622, ENST00000519848, ENST00000520142, ENST00000520804, ENST00000520868, ENST00000521067, ENST00000521865, ENST00000522387, ENST00000522658, ENST00000522720, ENST00000523555, ENST00000523636
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component pharyngeal arch
High 146 16 28 29 657 24 234 41 36 52 224 181 16 1 4
Medium 2286 2960 1695 593 1291 440 4121 2144 3667 366 1224 1427 155 1203 2784 4
Low 5 11 2 2 2 1 1 10 12 5 4 3 1 2
Below cutoff 2 16 1 6 1 1 1

Sequence

Nucleotide Sequences
RefSeq Transcripts NG_027520 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_002568 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_005250861 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AH007272 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK095194 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK130523 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK298990 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK303120 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL135187 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AP001205 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC015958 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC023217 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC023520 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC041863 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471060 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HI179042 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KT584582 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  Y00345 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  Z48501 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000318607   ⟹   ENSP00000313007
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl8100,702,916 - 100,722,088 (-)Ensembl
RefSeq Acc Id: ENST00000517403   ⟹   ENSP00000428190
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl8100,706,651 - 100,712,761 (-)Ensembl
RefSeq Acc Id: ENST00000517921
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl8100,713,138 - 100,721,583 (-)Ensembl
RefSeq Acc Id: ENST00000517990   ⟹   ENSP00000428030
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl8100,703,285 - 100,706,779 (-)Ensembl
RefSeq Acc Id: ENST00000518196   ⟹   ENSP00000430159
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl8100,717,817 - 100,722,036 (-)Ensembl
RefSeq Acc Id: ENST00000518293   ⟹   ENSP00000430716
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl8100,685,816 - 100,704,960 (-)Ensembl
RefSeq Acc Id: ENST00000518716
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl8100,706,703 - 100,709,847 (-)Ensembl
RefSeq Acc Id: ENST00000519004   ⟹   ENSP00000429594
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl8100,703,099 - 100,722,087 (-)Ensembl
RefSeq Acc Id: ENST00000519100   ⟹   ENSP00000427914
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl8100,709,459 - 100,717,890 (-)Ensembl
RefSeq Acc Id: ENST00000519363   ⟹   ENSP00000429032
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl8100,721,469 - 100,722,087 (-)Ensembl
RefSeq Acc Id: ENST00000519596
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl8100,706,694 - 100,715,601 (-)Ensembl
RefSeq Acc Id: ENST00000519622   ⟹   ENSP00000427805
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl8100,709,136 - 100,715,496 (-)Ensembl
RefSeq Acc Id: ENST00000519848
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl8100,704,926 - 100,707,191 (-)Ensembl
RefSeq Acc Id: ENST00000520142   ⟹   ENSP00000430012
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl8100,718,120 - 100,722,092 (-)Ensembl
RefSeq Acc Id: ENST00000520804   ⟹   ENSP00000428749
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl8100,721,453 - 100,722,753 (-)Ensembl
RefSeq Acc Id: ENST00000520868   ⟹   ENSP00000428021
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl8100,702,916 - 100,706,931 (-)Ensembl
RefSeq Acc Id: ENST00000521067   ⟹   ENSP00000428937
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl8100,721,401 - 100,722,809 (-)Ensembl
RefSeq Acc Id: ENST00000521865   ⟹   ENSP00000429119
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl8100,718,087 - 100,722,749 (-)Ensembl
RefSeq Acc Id: ENST00000522387   ⟹   ENSP00000429395
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl8100,703,161 - 100,721,992 (-)Ensembl
RefSeq Acc Id: ENST00000522658   ⟹   ENSP00000428840
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl8100,704,114 - 100,706,974 (-)Ensembl
RefSeq Acc Id: ENST00000522720   ⟹   ENSP00000429790
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl8100,718,249 - 100,722,762 (-)Ensembl
RefSeq Acc Id: ENST00000523555   ⟹   ENSP00000429892
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl8100,713,142 - 100,721,566 (-)Ensembl
RefSeq Acc Id: ENST00000523636   ⟹   ENSP00000428948
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl8100,703,259 - 100,712,404 (-)Ensembl
RefSeq Acc Id: ENST00000610907   ⟹   ENSP00000478108
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl8100,704,298 - 100,721,508 (-)Ensembl
RefSeq Acc Id: ENST00000676655
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl8100,702,795 - 100,719,663 (-)Ensembl
RefSeq Acc Id: ENST00000676662   ⟹   ENSP00000503686
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl8100,702,051 - 100,721,323 (-)Ensembl
RefSeq Acc Id: ENST00000676976
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl8100,702,795 - 100,718,994 (-)Ensembl
RefSeq Acc Id: ENST00000677140   ⟹   ENSP00000503044
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl8100,702,051 - 100,721,645 (-)Ensembl
RefSeq Acc Id: ENST00000677285
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl8100,703,138 - 100,705,695 (-)Ensembl
RefSeq Acc Id: ENST00000677380   ⟹   ENSP00000503421
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl8100,702,795 - 100,722,174 (-)Ensembl
RefSeq Acc Id: ENST00000677478   ⟹   ENSP00000504369
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl8100,702,795 - 100,722,185 (-)Ensembl
RefSeq Acc Id: ENST00000677765   ⟹   ENSP00000503838
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl8100,702,051 - 100,721,169 (-)Ensembl
RefSeq Acc Id: ENST00000677775
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl8100,702,795 - 100,722,087 (-)Ensembl
RefSeq Acc Id: ENST00000677787   ⟹   ENSP00000504835
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl8100,702,051 - 100,721,645 (-)Ensembl
RefSeq Acc Id: ENST00000677892
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl8100,702,051 - 100,716,312 (-)Ensembl
RefSeq Acc Id: ENST00000678290
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl8100,702,795 - 100,713,803 (-)Ensembl
RefSeq Acc Id: ENST00000678709
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl8100,702,051 - 100,721,559 (-)Ensembl
RefSeq Acc Id: ENST00000678822
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl8100,704,055 - 100,721,851 (-)Ensembl
RefSeq Acc Id: ENST00000678954   ⟹   ENSP00000503455
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl8100,702,795 - 100,721,904 (-)Ensembl
RefSeq Acc Id: ENST00000679197   ⟹   ENSP00000503058
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl8100,702,960 - 100,721,645 (-)Ensembl
RefSeq Acc Id: NM_002568   ⟹   NP_002559
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh388100,702,916 - 100,722,088 (-)NCBI
GRCh378101,715,144 - 101,734,969 (-)NCBI
Build 368101,784,320 - 101,803,491 (-)NCBI Archive
HuRef896,913,861 - 96,933,038 (-)ENTREZGENE
CHM1_18101,755,929 - 101,775,103 (-)NCBI
Sequence:
RefSeq Acc Id: XM_005250861   ⟹   XP_005250918
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh388100,702,916 - 100,722,087 (-)NCBI
GRCh378101,715,144 - 101,734,969 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_002559   ⟸   NM_002568
- UniProtKB: P11940 (UniProtKB/Swiss-Prot),   A0A024R9C1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005250918   ⟸   XM_005250861
- Peptide Label: isoform X1
- UniProtKB: P11940 (UniProtKB/Swiss-Prot),   A0A024R9C1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSP00000428190   ⟸   ENST00000517403
RefSeq Acc Id: ENSP00000428030   ⟸   ENST00000517990
RefSeq Acc Id: ENSP00000430159   ⟸   ENST00000518196
RefSeq Acc Id: ENSP00000430716   ⟸   ENST00000518293
RefSeq Acc Id: ENSP00000429594   ⟸   ENST00000519004
RefSeq Acc Id: ENSP00000429032   ⟸   ENST00000519363
RefSeq Acc Id: ENSP00000427914   ⟸   ENST00000519100
RefSeq Acc Id: ENSP00000427805   ⟸   ENST00000519622
RefSeq Acc Id: ENSP00000478108   ⟸   ENST00000610907
RefSeq Acc Id: ENSP00000430012   ⟸   ENST00000520142
RefSeq Acc Id: ENSP00000428021   ⟸   ENST00000520868
RefSeq Acc Id: ENSP00000428749   ⟸   ENST00000520804
RefSeq Acc Id: ENSP00000428937   ⟸   ENST00000521067
RefSeq Acc Id: ENSP00000429119   ⟸   ENST00000521865
RefSeq Acc Id: ENSP00000428840   ⟸   ENST00000522658
RefSeq Acc Id: ENSP00000429395   ⟸   ENST00000522387
RefSeq Acc Id: ENSP00000429790   ⟸   ENST00000522720
RefSeq Acc Id: ENSP00000429892   ⟸   ENST00000523555
RefSeq Acc Id: ENSP00000428948   ⟸   ENST00000523636
RefSeq Acc Id: ENSP00000313007   ⟸   ENST00000318607
RefSeq Acc Id: ENSP00000503686   ⟸   ENST00000676662
RefSeq Acc Id: ENSP00000503044   ⟸   ENST00000677140
RefSeq Acc Id: ENSP00000504369   ⟸   ENST00000677478
RefSeq Acc Id: ENSP00000503421   ⟸   ENST00000677380
RefSeq Acc Id: ENSP00000503838   ⟸   ENST00000677765
RefSeq Acc Id: ENSP00000504835   ⟸   ENST00000677787
RefSeq Acc Id: ENSP00000503455   ⟸   ENST00000678954
RefSeq Acc Id: ENSP00000503058   ⟸   ENST00000679197
Protein Domains
PABC   RRM

Promoters
RGD ID:7213899
Promoter ID:EPDNEW_H12695
Type:initiation region
Name:PABPC1_1
Description:poly binding protein cytoplasmic 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh388100,722,087 - 100,722,147EPDNEW
RGD ID:6813475
Promoter ID:HG_ACW:78174
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Lymphoblastoid
Transcripts:PABPC1.HAPR07,   PABPC1.IAPR07
Position:
Human AssemblyChrPosition (strand)Source
Build 368101,787,946 - 101,788,446 (-)MPROMDB
RGD ID:6806633
Promoter ID:HG_KWN:61811
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   CD4+TCell_2Hour,   HeLa_S3,   Jurkat,   K562,   Lymphoblastoid,   NB4
Transcripts:ENST00000347137,   NM_002568,   UC003YJT.1,   UC003YJU.1
Position:
Human AssemblyChrPosition (strand)Source
Build 368101,802,881 - 101,804,112 (-)MPROMDB

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 8q22.2-22.3(chr8:100023254-101190270)x3 copy number gain See cases [RCV000050759] Chr8:100023254..101190270 [GRCh38]
Chr8:101035482..102202498 [GRCh37]
Chr8:101104658..102271674 [NCBI36]
Chr8:8q22.2-22.3
pathogenic
GRCh38/hg38 8p23.3-q24.3(chr8:241530-145049449)x3 copy number gain See cases [RCV000051206] Chr8:241530..145049449 [GRCh38]
Chr8:191530..146274835 [GRCh37]
Chr8:181530..146245639 [NCBI36]
Chr8:8p23.3-q24.3
pathogenic
GRCh38/hg38 8q22.1-24.3(chr8:95606052-145054775)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053677]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053677]|See cases [RCV000053677] Chr8:95606052..145054775 [GRCh38]
Chr8:96618280..146280161 [GRCh37]
Chr8:96687456..146250965 [NCBI36]
Chr8:8q22.1-24.3
pathogenic
GRCh38/hg38 8p23.3-q24.3(chr8:244417-145054775)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053604]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053604]|See cases [RCV000053604] Chr8:244417..145054775 [GRCh38]
Chr8:194417..146280161 [GRCh37]
Chr8:184417..146250965 [NCBI36]
Chr8:8p23.3-q24.3
pathogenic
GRCh38/hg38 8p23.3-q24.3(chr8:241530-145054634)x3 copy number gain See cases [RCV000053602] Chr8:241530..145054634 [GRCh38]
Chr8:191530..146280020 [GRCh37]
Chr8:181530..146250824 [NCBI36]
Chr8:8p23.3-q24.3
pathogenic
NM_002568.3(PABPC1):c.1033G>T (p.Glu345Ter) single nucleotide variant Malignant melanoma [RCV000068052] Chr8:100709671 [GRCh38]
Chr8:101721899 [GRCh37]
Chr8:101791075 [NCBI36]
Chr8:8q22.3
not provided
GRCh37/hg19 8p12-q24.3(chr8:31936551-146295771)x3 copy number gain not provided [RCV000848192] Chr8:31936551..146295771 [GRCh37]
Chr8:8p12-q24.3
pathogenic
GRCh38/hg38 8q22.1-24.3(chr8:94682154-145068656)x3 copy number gain See cases [RCV000134353] Chr8:94682154..145068656 [GRCh38]
Chr8:95694382..146294042 [GRCh37]
Chr8:95763558..146264846 [NCBI36]
Chr8:8q22.1-24.3
pathogenic
GRCh38/hg38 8q21.3-24.23(chr8:86300584-137022587)x3 copy number gain See cases [RCV000135621] Chr8:86300584..137022587 [GRCh38]
Chr8:87312813..138034830 [GRCh37]
Chr8:87381929..138104012 [NCBI36]
Chr8:8q21.3-24.23
pathogenic|likely pathogenic
GRCh38/hg38 8q22.2-22.3(chr8:99580206-101547228)x1 copy number loss See cases [RCV000137322] Chr8:99580206..101547228 [GRCh38]
Chr8:100592434..102559456 [GRCh37]
Chr8:100661610..102628632 [NCBI36]
Chr8:8q22.2-22.3
likely pathogenic
GRCh38/hg38 8p23.3-q24.3(chr8:241605-145054781)x3 copy number gain See cases [RCV000138643] Chr8:241605..145054781 [GRCh38]
Chr8:191605..146280167 [GRCh37]
Chr8:181605..146250971 [NCBI36]
Chr8:8p23.3-q24.3
pathogenic
GRCh38/hg38 8q21.3-24.3(chr8:87931152-145068712)x3 copy number gain See cases [RCV000138551] Chr8:87931152..145068712 [GRCh38]
Chr8:88943380..146294098 [GRCh37]
Chr8:89012496..146264902 [NCBI36]
Chr8:8q21.3-24.3
pathogenic
GRCh38/hg38 8q21.13-24.3(chr8:77480050-145068712)x3 copy number gain See cases [RCV000139036] Chr8:77480050..145068712 [GRCh38]
Chr8:78392286..146294098 [GRCh37]
Chr8:78554841..146264902 [NCBI36]
Chr8:8q21.13-24.3
pathogenic
GRCh38/hg38 8q22.1-24.3(chr8:97382873-145070385)x3 copy number gain See cases [RCV000140447] Chr8:97382873..145070385 [GRCh38]
Chr8:98395101..146295771 [GRCh37]
Chr8:98464277..146266575 [NCBI36]
Chr8:8q22.1-24.3
pathogenic
GRCh38/hg38 8q11.1-24.3(chr8:46031340-139285494)x3 copy number gain See cases [RCV000139539] Chr8:46031340..139285494 [GRCh38]
Chr8:46942962..140297737 [GRCh37]
Chr8:47062127..140366919 [NCBI36]
Chr8:8q11.1-24.3
pathogenic
GRCh38/hg38 8q22.2-23.1(chr8:100179408-106524667)x1 copy number loss See cases [RCV000141697] Chr8:100179408..106524667 [GRCh38]
Chr8:101191636..107536895 [GRCh37]
Chr8:101260812..107606071 [NCBI36]
Chr8:8q22.2-23.1
pathogenic
GRCh38/hg38 8p23.3-q24.3(chr8:208048-145070385)x3 copy number gain See cases [RCV000141808] Chr8:208048..145070385 [GRCh38]
Chr8:158048..146295771 [GRCh37]
Chr8:148048..146266575 [NCBI36]
Chr8:8p23.3-q24.3
pathogenic
GRCh38/hg38 8p21.3-q24.3(chr8:21291522-145070385)x3 copy number gain See cases [RCV000142021] Chr8:21291522..145070385 [GRCh38]
Chr8:21149033..146295771 [GRCh37]
Chr8:21193313..146266575 [NCBI36]
Chr8:8p21.3-q24.3
pathogenic
GRCh38/hg38 8p23.3-q24.3(chr8:226452-145068712)x3 copy number gain See cases [RCV000142858] Chr8:226452..145068712 [GRCh38]
Chr8:176452..146294098 [GRCh37]
Chr8:166452..146264902 [NCBI36]
Chr8:8p23.3-q24.3
pathogenic
GRCh38/hg38 8q21.13-24.3(chr8:78614077-145054634)x3 copy number gain See cases [RCV000142597] Chr8:78614077..145054634 [GRCh38]
Chr8:79526312..146280020 [GRCh37]
Chr8:79688867..146250824 [NCBI36]
Chr8:8q21.13-24.3
pathogenic
GRCh38/hg38 8p23.3-q24.3(chr8:241530-145054634)x3 copy number gain See cases [RCV000148092] Chr8:241530..145054634 [GRCh38]
Chr8:191530..146280020 [GRCh37]
Chr8:181530..146250824 [NCBI36]
Chr8:8p23.3-q24.3
pathogenic
GRCh38/hg38 8q21.2-24.3(chr8:85765999-145070385)x3 copy number gain See cases [RCV000143659] Chr8:85765999..145070385 [GRCh38]
Chr8:86778228..146295771 [GRCh37]
Chr8:86863079..146266575 [NCBI36]
Chr8:8q21.2-24.3
pathogenic
GRCh37/hg19 8p23.3-q24.3(chr8:158991-146280828)x3 copy number gain See cases [RCV000447507] Chr8:158991..146280828 [GRCh37]
Chr8:8p23.3-q24.3
pathogenic
GRCh37/hg19 8q22.1-24.3(chr8:98432250-146222672)x4 copy number gain See cases [RCV000448954] Chr8:98432250..146222672 [GRCh37]
Chr8:8q22.1-24.3
pathogenic
GRCh37/hg19 8p23.3-q24.3(chr8:158049-146295771) copy number gain See cases [RCV000510234] Chr8:158049..146295771 [GRCh37]
Chr8:8p23.3-q24.3
pathogenic
GRCh37/hg19 8q21.3-24.3(chr8:93047482-141355635)x3 copy number gain See cases [RCV000511761] Chr8:93047482..141355635 [GRCh37]
Chr8:8q21.3-24.3
pathogenic
GRCh37/hg19 8p23.3-q24.3(chr8:158049-146295771)x3 copy number gain See cases [RCV000511095] Chr8:158049..146295771 [GRCh37]
Chr8:8p23.3-q24.3
pathogenic
GRCh37/hg19 8q21.2-24.3(chr8:86841154-146295771)x3 copy number gain See cases [RCV000511002] Chr8:86841154..146295771 [GRCh37]
Chr8:8q21.2-24.3
pathogenic
GRCh37/hg19 8q21.2-24.3(chr8:86841228-142689874)x3 copy number gain See cases [RCV000510854] Chr8:86841228..142689874 [GRCh37]
Chr8:8q21.2-24.3
pathogenic
GRCh37/hg19 8p23.1-q24.3(chr8:12490999-146295771)x3 copy number gain See cases [RCV000512169] Chr8:12490999..146295771 [GRCh37]
Chr8:8p23.1-q24.3
pathogenic
GRCh37/hg19 8q22.2-22.3(chr8:100551211-103676738)x1 copy number loss not provided [RCV000683023] Chr8:100551211..103676738 [GRCh37]
Chr8:8q22.2-22.3
pathogenic
GRCh37/hg19 8q21.2-23.3(chr8:86841154-116518125)x3 copy number gain not provided [RCV000683045] Chr8:86841154..116518125 [GRCh37]
Chr8:8q21.2-23.3
pathogenic
GRCh37/hg19 8p23.3-q24.3(chr8:164984-146293414)x3 copy number gain not provided [RCV000747254] Chr8:164984..146293414 [GRCh37]
Chr8:8p23.3-q24.3
pathogenic
GRCh37/hg19 8p23.3-q24.3(chr8:10213-146293414)x3 copy number gain not provided [RCV000747248] Chr8:10213..146293414 [GRCh37]
Chr8:8p23.3-q24.3
pathogenic
GRCh37/hg19 8q22.3(chr8:101717182-101730110)x3 copy number gain not provided [RCV000747738] Chr8:101717182..101730110 [GRCh37]
Chr8:8q22.3
benign
GRCh37/hg19 8q22.3(chr8:101721727-101730110)x3 copy number gain not provided [RCV000747739] Chr8:101721727..101730110 [GRCh37]
Chr8:8q22.3
benign
GRCh37/hg19 8q22.3(chr8:101724606-101730110)x3 copy number gain not provided [RCV000747740] Chr8:101724606..101730110 [GRCh37]
Chr8:8q22.3
benign
NM_002568.4(PABPC1):c.*2-1_*2insCCACTGGTGTTCCAACTGTTTAAA insertion CIC-DUX Sarcoma [RCV000993823] Chr8:100703359..100703360 [GRCh38]
Chr8:101715587..101715588 [GRCh37]
Chr8:8q22.3
not provided
NM_002568.4(PABPC1):c.739-18dup duplication not provided [RCV000949322] Chr8:100712798..100712799 [GRCh38]
Chr8:101725026..101725027 [GRCh37]
Chr8:8q22.3
benign
NM_002568.4(PABPC1):c.1688-8G>A single nucleotide variant not provided [RCV000958611] Chr8:100705064 [GRCh38]
Chr8:101717292 [GRCh37]
Chr8:8q22.3
benign
NM_002568.4(PABPC1):c.388-4C>T single nucleotide variant not provided [RCV000906538] Chr8:100717892 [GRCh38]
Chr8:101730120 [GRCh37]
Chr8:8q22.3
benign
NM_002568.4(PABPC1):c.1290A>G (p.Gln430=) single nucleotide variant not provided [RCV000929940] Chr8:100709179 [GRCh38]
Chr8:101721407 [GRCh37]
Chr8:8q22.3
benign
GRCh37/hg19 8p23.3-q24.3(chr8:158048-146295771)x3 copy number gain not provided [RCV000848478] Chr8:158048..146295771 [GRCh37]
Chr8:8p23.3-q24.3
pathogenic

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:8554 AgrOrtholog
COSMIC PABPC1 COSMIC
Ensembl Genes ENSG00000070756 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSP00000313007 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000427805 UniProtKB/TrEMBL
  ENSP00000427914 UniProtKB/TrEMBL
  ENSP00000428021 UniProtKB/TrEMBL
  ENSP00000428030 UniProtKB/TrEMBL
  ENSP00000428190 UniProtKB/TrEMBL
  ENSP00000428749 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSP00000428840 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSP00000428937 UniProtKB/TrEMBL
  ENSP00000428948 UniProtKB/TrEMBL
  ENSP00000429032 UniProtKB/TrEMBL
  ENSP00000429119 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSP00000429395 UniProtKB/TrEMBL
  ENSP00000429594 UniProtKB/TrEMBL
  ENSP00000429790 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSP00000429892 ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSP00000430012 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSP00000430159 UniProtKB/TrEMBL
  ENSP00000430716 UniProtKB/TrEMBL
  ENSP00000478108 UniProtKB/TrEMBL
  ENSP00000503044 UniProtKB/TrEMBL
  ENSP00000503058 UniProtKB/TrEMBL
  ENSP00000503421 UniProtKB/TrEMBL
  ENSP00000503455 UniProtKB/TrEMBL
  ENSP00000503686 UniProtKB/TrEMBL
  ENSP00000503838 UniProtKB/TrEMBL
  ENSP00000504369 UniProtKB/TrEMBL
  ENSP00000504835 UniProtKB/TrEMBL
Ensembl Transcript ENST00000318607 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000517403 UniProtKB/TrEMBL
  ENST00000517990 UniProtKB/TrEMBL
  ENST00000518196 UniProtKB/TrEMBL
  ENST00000518293 UniProtKB/TrEMBL
  ENST00000519004 UniProtKB/TrEMBL
  ENST00000519100 UniProtKB/TrEMBL
  ENST00000519363 UniProtKB/TrEMBL
  ENST00000519622 UniProtKB/TrEMBL
  ENST00000520142 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENST00000520804 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENST00000520868 UniProtKB/TrEMBL
  ENST00000521067 UniProtKB/TrEMBL
  ENST00000521865 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENST00000522387 UniProtKB/TrEMBL
  ENST00000522658 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENST00000522720 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENST00000523555 ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENST00000523636 UniProtKB/TrEMBL
  ENST00000610907 UniProtKB/TrEMBL
  ENST00000676662 UniProtKB/TrEMBL
  ENST00000677140 UniProtKB/TrEMBL
  ENST00000677380 UniProtKB/TrEMBL
  ENST00000677478 UniProtKB/TrEMBL
  ENST00000677765 UniProtKB/TrEMBL
  ENST00000677787 UniProtKB/TrEMBL
  ENST00000678954 UniProtKB/TrEMBL
  ENST00000679197 UniProtKB/TrEMBL
Gene3D-CATH 3.30.70.330 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000070756 GTEx
HGNC ID HGNC:8554 ENTREZGENE
Human Proteome Map PABPC1 Human Proteome Map
InterPro Nucleotide-bd_a/b_plait_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PABP-dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PABP_1234 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PABP_HYD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RBD_domain_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RRM_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RRM_dom_euk UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:26986 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 26986 ENTREZGENE
OMIM 604679 OMIM
Pfam PABP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RRM_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA32880 PharmGKB
PROSITE PABC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RRM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART PolyA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RRM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RRM_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF54928 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF63570 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGRFAMs PABP-1234 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A024R9C1 ENTREZGENE, UniProtKB/TrEMBL
  A0A024R9E2_HUMAN UniProtKB/TrEMBL
  A0A087WTT1_HUMAN UniProtKB/TrEMBL
  A0A7I2V3J9_HUMAN UniProtKB/TrEMBL
  A0A7I2V4N4_HUMAN UniProtKB/TrEMBL
  A0A7I2V649_HUMAN UniProtKB/TrEMBL
  A0A7I2YQ88_HUMAN UniProtKB/TrEMBL
  A0A7I2YQ90_HUMAN UniProtKB/TrEMBL
  A0A7I2YQE4_HUMAN UniProtKB/TrEMBL
  E5RFD8_HUMAN UniProtKB/TrEMBL
  E5RGC4_HUMAN UniProtKB/TrEMBL
  E5RGH3_HUMAN UniProtKB/TrEMBL
  E5RH24_HUMAN UniProtKB/TrEMBL
  E5RHG7_HUMAN UniProtKB/TrEMBL
  E5RJB9_HUMAN UniProtKB/TrEMBL
  E5RJM8_HUMAN UniProtKB/TrEMBL
  E7EQV3_HUMAN UniProtKB/TrEMBL
  E7ERJ7_HUMAN UniProtKB/TrEMBL
  H0YAP2_HUMAN UniProtKB/TrEMBL
  H0YAR2_HUMAN UniProtKB/TrEMBL
  H0YAS6_HUMAN UniProtKB/TrEMBL
  H0YAS7_HUMAN UniProtKB/TrEMBL
  H0YAW6_HUMAN UniProtKB/TrEMBL
  H0YB75_HUMAN UniProtKB/TrEMBL
  H0YB86_HUMAN UniProtKB/TrEMBL
  H0YBN4_HUMAN UniProtKB/TrEMBL
  H0YC10_HUMAN UniProtKB/TrEMBL
  P11940 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary Q15097 UniProtKB/Swiss-Prot
  Q93004 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-04-04 PABPC1  poly(A) binding protein cytoplasmic 1    poly(A) binding protein, cytoplasmic 1  Symbol and/or name change 5135510 APPROVED