| 2542 | Egf | epidermal growth factor | ENCODES a protein that exhibits epidermal growth factor receptor binding; growth factor activity (ortholog); guanyl-nucleotide exchange factor activity (ortholog); INVOLVED IN epidermal growth factor receptor signaling pathway; kidney development; positive regulation of DNA biosynthetic process; PAR TICIPATES IN epidermal growth factor/neuregulin signaling pathway; altered epidermal growth factor/neuregulin signaling pathway; ceramide signaling pathway; ASSOCIATED WITH acute kidney failure; perinatal necrotizing enterocolitis; Wounds and Injuries; FOUND IN extracellular space; extracellular exosome (ortholog); plasma membrane (ortholog); INTERACTS WITH (+)-schisandrin B; (R)-noradrenaline; 1,2-dimethylhydrazine | 2 | 220893660 | 220976331 | Rat | 754 | symbol , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 10510 | Egf | epidermal growth factor | This gene encodes epidermal growth factor (EGF), the founding member of the EGF family of growth factors that are implicated in cell proliferation and differentiation. The encoded protein can localize to the membrane and fun ction in juxtacrine signaling or undergo proteolytic processing to generate a soluble form of the hormone. Mice lacking the encoded protein do not exhibit an abnormal phenotype but transgenic mice overexpressing the encoded protein exhibit hypospermatogenesis. [provided by RefSeq, Jul 2016] | 3 | 129471223 | 129548971 | Mouse | 782 | symbol , old_gene_name , PhenoGen , description | gene, protein-coding, REVIEWED [RefSeq] |
| 736832 | EGF | epidermal growth factor | This gene encodes a member of the epidermal growth factor superfamily. The encoded preproprotein is proteolytically processed to generate the 53-amino acid epidermal growth factor peptide. This protein acts a potent mitogenic factor that plays an important role in the growth, proliferation and diffe rentiation of numerous cell types. This protein acts by binding with high affinity to the cell surface receptor, epidermal growth factor receptor. Defects in this gene are the cause of hypomagnesemia type 4. Dysregulation of this gene has been associated with the growth and progression of certain cancers. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed. [provided by RefSeq, Jan 2016] | 4 | 109912883 | 110013766 | Human | 750 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 8884290 | Egf | epidermal growth factor | ENCODES a protein that exhibits epidermal growth factor receptor binding (ortholog); growth factor activity (ortholog); guanyl-nucleotide exchange factor activity (ortholog); INVOLVED IN angiogenesis (ortholog); branching morphogenesis of an epithelial tube (ortholog); epidermal growth factor recept or signaling pathway (ortholog); PARTICIPATES IN altered epidermal growth factor/neuregulin signaling pathway; ceramide signaling pathway; E-cadherin signaling pathway; ASSOCIATED WITH acute kidney failure (ortholog); adenocarcinoma (ortholog); AIDS-Associated Nephropathy (ortholog); FOUND IN extracellular exosome (ortholog); extracellular space (ortholog); plasma membrane (ortholog) | NW_004955496 | 325954 | 401430 | Chinchilla | 144 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11955338 | EGF | epidermal growth factor | ENCODES a protein that exhibits epidermal growth factor receptor binding (ortholog); INVOLVED IN branching morphogenesis of an epithelial tube (ortholog); epidermal growth factor receptor signaling pathway (ortholog); ERBB2-EGFR signaling pathway (ortholog); PAR TICIPATES IN altered epidermal growth factor/neuregulin signaling pathway; ceramide signaling pathway; E-cadherin signaling pathway; ASSOCIATED WITH acute kidney failure (ortholog); adenocarcinoma (ortholog); AIDS-Associated Nephropathy (ortholog); FOUND IN extracellular space (ortholog) | 4 | 102410724 | 102509691 | Bonobo | 155 | symbol , description | gene, protein-coding, MODEL [RefSeq] |
| 12168776 | EGF | epidermal growth factor | ENCODES a protein that exhibits epidermal growth factor receptor binding (ortholog); INVOLVED IN branching morphogenesis of an epithelial tube (ortholog); epidermal growth factor receptor signaling pathway (ortholog); ERBB2-EGFR signaling pathway (ortholog); PAR TICIPATES IN altered epidermal growth factor/neuregulin signaling pathway; ceramide signaling pathway; E-cadherin signaling pathway; ASSOCIATED WITH acute kidney failure (ortholog); adenocarcinoma (ortholog); AIDS-Associated Nephropathy (ortholog); FOUND IN extracellular space (ortholog) | 32 | 30073541 | 30166904 | Dog | 156 | symbol , description , old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 12723576 | Egf | epidermal growth factor | ENCODES a protein that exhibits epidermal growth factor receptor binding (ortholog); growth factor activity (ortholog); guanyl-nucleotide exchange factor activity (ortholog); INVOLVED IN angiogenesis (ortholog); branching morphogenesis of an epithelial tube (ortholog); epidermal growth factor recept or signaling pathway (ortholog); PARTICIPATES IN altered epidermal growth factor/neuregulin signaling pathway; ceramide signaling pathway; E-cadherin signaling pathway; ASSOCIATED WITH acute kidney failure (ortholog); adenocarcinoma (ortholog); AIDS-Associated Nephropathy (ortholog); FOUND IN extracellular exosome (ortholog); extracellular space (ortholog); plasma membrane (ortholog) | NW_004936563 | 1058803 | 1181393 | Squirrel | 144 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 13916117 | EGF | epidermal growth factor | ENCODES a protein that exhibits epidermal growth factor receptor binding (ortholog); INVOLVED IN branching morphogenesis of an epithelial tube (ortholog); epidermal growth factor receptor signaling pathway (ortholog); ERBB2-EGFR signaling pathway (ortholog); PAR TICIPATES IN altered epidermal growth factor/neuregulin signaling pathway; ceramide signaling pathway; E-cadherin signaling pathway; ASSOCIATED WITH acute kidney failure (ortholog); adenocarcinoma (ortholog); AIDS-Associated Nephropathy (ortholog); FOUND IN extracellular space (ortholog); INTERACTS WITH deoxynivalenol | | | | Pig | 158 | symbol , description | gene, protein-coding, PROVISIONAL [RefSeq] |
| 18687900 | EGF | epidermal growth factor | ENCODES a protein that exhibits epidermal growth factor receptor binding (ortholog); INVOLVED IN branching morphogenesis of an epithelial tube (ortholog); epidermal growth factor receptor signaling pathway (ortholog); ERBB2-EGFR signaling pathway (ortholog); PAR TICIPATES IN altered epidermal growth factor/neuregulin signaling pathway; ceramide signaling pathway; E-cadherin signaling pathway; ASSOCIATED WITH acute kidney failure (ortholog); adenocarcinoma (ortholog); AIDS-Associated Nephropathy (ortholog); FOUND IN extracellular space (ortholog) | | | | Green Monkey | 155 | symbol , description | gene, protein-coding, MODEL [RefSeq] |
| 155245559 | egf | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 626113712 | Egf | epidermal growth factor | ENCODES a protein that exhibits epidermal growth factor receptor binding (ortholog); growth factor activity (ortholog); guanyl-nucleotide exchange factor activity (ortholog); INVOLVED IN angiogenesis (ortholog); branching morphogenesis of an epithelial tube (ortholog); epidermal growth factor recept or signaling pathway (ortholog); PARTICIPATES IN altered epidermal growth factor/neuregulin signaling pathway; ceramide signaling pathway; E-cadherin signaling pathway; ASSOCIATED WITH acute kidney failure (ortholog); adenocarcinoma (ortholog); AIDS-Associated Nephropathy (ortholog); FOUND IN extracellular exosome (ortholog); extracellular space (ortholog); plasma membrane (ortholog) | | | | Black Rat | 144 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155238402 | egf.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 18932057 | LOC106007527 | pro-epidermal growth factor | ENCODES a protein that exhibits calcium ion binding (inferred); growth factor activity (inferred); Wnt receptor activity (inferred); INVOLVED IN canonical Wnt signaling pathway (inferred); epidermal growth factor receptor signaling pathway (inferred); positive regulation of cell population prolifera tion (inferred); FOUND IN plasma membrane (inferred) | | | | Naked Mole-Rat | 9 | old_gene_symbol | gene, protein-coding, MODEL [RefSeq] |
| 2526 | Hbegf | heparin-binding EGF-like growth factor | ENCODES a protein that exhibits epidermal growth factor receptor binding; growth factor activity; heparin binding (ortholog); INVOLVED IN epidermal growth factor receptor signaling pathway; negative regulation of glycoprotein biosynthetic process; positive regulation of cell growth; PARTICIPATES IN epidermal growth factor/neuregulin signaling pathway; gonadotropin-releasing hormone signaling pathway; ASSOCIATED WITH acute kidney failure; Animal Disease Models (ortholog); Cardiotoxicity (ortholog); FOUND IN cell surface (ortholog); extracellular space (ortholog); plasma membrane (ortholog); INTERACTS WITH (+)-schisandrin B; 1,2,4-trimethylbenzene; 17beta-estradiol | 18 | 28380337 | 28390220 | Rat | 413 | symbol , old_gene_name , PhenoGen , name , old_gene_symbol | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1553497 | Adgre1 | adhesion G protein-coupled receptor E1 | Predicted to enable G protein-coupled receptor activity. Predicted to be involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway. Located in external side of plasma membrane. Is expressed in several structures, including cardiovascular system; central nervous system; ge nitourinary system; hemolymphoid system; and intestine. Orthologous to human ADGRE1 (adhesion G protein-coupled receptor E1). [provided by Alliance of Genome Resources, Apr 2025] | 17 | 57665650 | 57790527 | Mouse | 198 | old_gene_name , old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 1550875 | Adgre4 | adhesion G protein-coupled receptor E4 | Predicted to enable G protein-coupled receptor activity. Predicted to be involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway. Predicted to act upstream of or within epidermal growth factor receptor signaling pathway. Located in cell surface. Is expressed in alimenta ry system; gonad; and metanephros. Orthologous to human ADGRE4P (adhesion G protein-coupled receptor E4, pseudogene). [provided by Alliance of Genome Resources, Apr 2025] | 17 | 56056984 | 56160662 | Mouse | 78 | old_gene_name , old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 1332497 | Egfl7 | EGF-like domain 7 | Enables Notch binding activity. Involved in vasculogenesis. Acts upstream of or within negative regulation of smooth muscle cell migration. Located in extracellular space. Is expressed in several structures, including cardiovascular system; early conceptus; embryo mesenchyme; genitourinary system; a nd retina. Orthologous to human EGFL7 (EGF like domain multiple 7). [provided by Alliance of Genome Resources, Jul 2025] | 2 | 26471095 | 26482694 | Mouse | 130 | symbol , old_gene_name , PhenoGen , name , description | gene, protein-coding, VALIDATED [RefSeq] |
| 1615005 | Egfl8 | EGF-like domain 8 | Predicted to enable signaling receptor binding activity. Predicted to be involved in vasculogenesis. Predicted to be active in cell surface and extracellular region. Is expressed in several structures, including diaphragm; genitourinary system; gut; hemolymphoid system gland; and trigeminal nerve. O rthologous to human EGFL8 (EGF like domain multiple 8). [provided by Alliance of Genome Resources, Jul 2025] | 17 | 34832174 | 34835536 | Mouse | 47 | symbol , old_gene_name , PhenoGen , name , description | gene, protein-coding, VALIDATED [RefSeq] |
| 1354247 | EGFL6 | EGF like domain multiple 6 | This gene encodes a member of the epidermal growth factor (EGF) repeat superfamily. Members of this superfamily are characterized by the presence of EGF-like repeats and are often involved in the regulation of cell cycle, pr oliferation, and developmental processes. The gene product contains a signal peptide, suggesting that it is secreted; an EGF repeat region consisting of 4 complete EGF-like repeats and 1 partial EGF-like repeat, 3 of which have a calcium-binding consensus sequence; an arg-gly-asp integrin association motif; and a MAM domain, which is believed to have an adhesive function. This gene is expressed early during development, and its expression has been detected in lung and meningioma tumors. [provided by RefSeq, Jul 2008] | X | 13569601 | 13633575 | Human | 92 | symbol , old_gene_name , COSMIC , name , description , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 8802559 | Egfl6 | EGF like domain multiple 6 | INVOLVED IN extracellular matrix organization (ortholog); positive regulation of cell-substrate adhesion (ortholog); ASSOCIATED WITH bladder exstrophy-epispadias-cloacal exstrophy complex (ortholog); FOUND IN basement membrane (ortholog); extracellular matrix (ortholog) | NW_004955519 | 4557007 | 4616095 | Chinchilla | 6 | symbol , old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 11966703 | EGFL6 | EGF like domain multiple 6 | ENCODES a protein that exhibits calcium ion binding (inferred); integrin binding (inferred); INVOLVED IN extracellular matrix organization (ortholog); positive regulation of cell-substrate adhesion (ortholog); ASSOCIATED WITH bladder exstrophy-epispadias-cloacal exstrophy complex (ortholog); FOUND I N basement membrane (ortholog); extracellular matrix (ortholog) | X | 6177141 | 6240969 | Bonobo | 12 | symbol , name | gene, protein-coding, MODEL [RefSeq] |
| 12065075 | EGFL6 | EGF like domain multiple 6 | ENCODES a protein that exhibits calcium ion binding (inferred); INVOLVED IN extracellular matrix organization (ortholog); positive regulation of cell-substrate adhesion (ortholog); ASSOCIATED WITH bladder exstrophy-epispadias-cloacal exstrophy complex (ortholog); FOUND IN basement membrane (inferred ); extracellular matrix (inferred); membrane (inferred) | X | 9944648 | 10062699 | Dog | 10 | symbol , name | gene, protein-coding, MODEL [RefSeq] |
| 12595709 | Egfl6 | EGF like domain multiple 6 | ENCODES a protein that exhibits calcium ion binding (inferred); INVOLVED IN extracellular matrix organization (ortholog); positive regulation of cell-substrate adhesion (ortholog); ASSOCIATED WITH bladder exstrophy-epispadias-cloacal exstrophy complex (ortholog); FOUND IN basement membrane (inferred ); extracellular matrix (inferred); membrane (inferred) | NW_004936470 | 3156593 | 3215039 | Squirrel | 12 | symbol , name | gene, protein-coding, MODEL [RefSeq] |
| 14085480 | EGFL6 | EGF like domain multiple 6 | ENCODES a protein that exhibits calcium ion binding (inferred); INVOLVED IN extracellular matrix organization (ortholog); positive regulation of cell-substrate adhesion (ortholog); ASSOCIATED WITH bladder exstrophy-epispadias-cloacal exstrophy complex (ortholog); FOUND IN basement membrane (inferred ); extracellular matrix (inferred); membrane (inferred) | | | | Pig | 10 | symbol , name | gene, protein-coding, MODEL [RefSeq] |
| 18723952 | EGFL6 | EGF like domain multiple 6 | ENCODES a protein that exhibits calcium ion binding (inferred); INVOLVED IN extracellular matrix organization (ortholog); positive regulation of cell-substrate adhesion (ortholog); ASSOCIATED WITH bladder exstrophy-epispadias-cloacal exstrophy complex (ortholog); FOUND IN basement membrane (inferred ); extracellular matrix (inferred); membrane (inferred) | | | | Green Monkey | 10 | symbol , name | gene, protein-coding, MODEL [RefSeq] |
| 18910222 | Egfl6 | EGF like domain multiple 6 | ENCODES a protein that exhibits calcium ion binding (inferred); INVOLVED IN extracellular matrix organization (ortholog); positive regulation of cell-substrate adhesion (ortholog); ASSOCIATED WITH bladder exstrophy-epispadias-cloacal exstrophy complex (ortholog); FOUND IN basement membrane (ortholog ); extracellular matrix (ortholog) | | | | Naked Mole-Rat | 12 | symbol , old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 626088237 | Egfl6 | EGF like domain multiple 6 | INVOLVED IN extracellular matrix organization (ortholog); positive regulation of cell-substrate adhesion (ortholog); ASSOCIATED WITH bladder exstrophy-epispadias-cloacal exstrophy complex (ortholog); FOUND IN basement membrane (ortholog); extracellular matrix (ortholog) | | | | Black Rat | 6 | symbol , name | gene, protein-coding, MODEL [RefSeq] |
| 1602888 | EGFL7 | EGF like domain multiple 7 | This gene encodes a secreted endothelial cell protein that contains two epidermal growth factor-like domains. The encoded protein may play a role in regulating vasculogenesis. This protein may be involved in the growth and proliferation of tumor cells. Alternate splicing results in multiple transcri pt variants. [provided by RefSeq, Feb 2012] | 9 | 136658856 | 136672678 | Human | 117 | symbol , old_gene_name , COSMIC , name , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 8754735 | Egfl7 | EGF like domain multiple 7 | ENCODES a protein that exhibits Notch binding (ortholog); INVOLVED IN blood vessel development (ortholog); negative regulation of cell migration (ortholog); negative regulation of Notch signaling pathway (ortholog); ASSOCIATED WITH developmental and epileptic encephalopathy 14 (ortholog); FOUND IN e xtracellular region (ortholog); extracellular space (ortholog) | NW_004955513 | 4145059 | 4154918 | Chinchilla | 11 | symbol , old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 12045710 | EGFL7 | EGF like domain multiple 7 | ENCODES a protein that exhibits Notch binding (ortholog); INVOLVED IN blood vessel development (ortholog); negative regulation of cell migration (ortholog); negative regulation of Notch signaling pathway (ortholog); ASSOCIATED WITH developmental and epileptic encephalopathy 14 (ortholog); FOUND IN e xtracellular space (ortholog) | 9 | 107735192 | 107748729 | Bonobo | 18 | symbol , name | gene, protein-coding, MODEL [RefSeq] |
| 12285246 | EGFL7 | EGF like domain multiple 7 | ENCODES a protein that exhibits Notch binding (ortholog); INVOLVED IN blood vessel development (ortholog); negative regulation of cell migration (ortholog); negative regulation of Notch signaling pathway (ortholog); ASSOCIATED WITH developmental and epileptic encephalopathy 14 (ortholog); FOUND IN e xtracellular space (ortholog) | 9 | 48878075 | 48890002 | Dog | 18 | symbol , name | gene, protein-coding, MODEL [RefSeq] |
| 12486996 | Egfl7 | EGF like domain multiple 7 | ENCODES a protein that exhibits Notch binding (ortholog); INVOLVED IN blood vessel development (ortholog); negative regulation of cell migration (ortholog); negative regulation of Notch signaling pathway (ortholog); ASSOCIATED WITH developmental and epileptic encephalopathy 14 (ortholog); FOUND IN e xtracellular space (ortholog) | NW_004936669 | 1199416 | 1211367 | Squirrel | 17 | symbol , old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 13910089 | EGFL7 | EGF like domain multiple 7 | ENCODES a protein that exhibits Notch binding (ortholog); INVOLVED IN blood vessel development (ortholog); negative regulation of cell migration (ortholog); negative regulation of Notch signaling pathway (ortholog); ASSOCIATED WITH developmental and epileptic encephalopathy 14 (ortholog); FOUND IN e xtracellular space (ortholog); INTERACTS WITH deoxynivalenol | | | | Pig | 19 | symbol , name | gene, protein-coding, MODEL [RefSeq] |
| 18420748 | EGFL7 | EGF like domain multiple 7 | ENCODES a protein that exhibits Notch binding (ortholog); INVOLVED IN blood vessel development (ortholog); negative regulation of cell migration (ortholog); negative regulation of Notch signaling pathway (ortholog); ASSOCIATED WITH developmental and epileptic encephalopathy 14 (ortholog); FOUND IN e xtracellular region (ortholog); extracellular space (ortholog) | | | | Green Monkey | 11 | symbol , name | gene, protein-coding, MODEL [RefSeq] |
| 18907543 | Egfl7 | EGF like domain multiple 7 | ENCODES a protein that exhibits Notch binding (ortholog); INVOLVED IN blood vessel development (ortholog); negative regulation of cell migration (ortholog); negative regulation of Notch signaling pathway (ortholog); ASSOCIATED WITH developmental and epileptic encephalopathy 14 (ortholog); FOUND IN e xtracellular space (ortholog) | | | | Naked Mole-Rat | 18 | symbol , name | gene, protein-coding, MODEL [RefSeq] |
| 626078979 | Egfl7 | EGF like domain multiple 7 | ENCODES a protein that exhibits Notch binding (ortholog); INVOLVED IN blood vessel development (ortholog); negative regulation of cell migration (ortholog); negative regulation of Notch signaling pathway (ortholog); FOUND IN extracellular region (ortholog); extracellular space (ortholog) | | | | Black Rat | 10 | symbol , name | gene, protein-coding, MODEL [RefSeq] |
| 1347289 | EGFL8 | EGF like domain multiple 8 | Predicted to enable signaling receptor binding activity. Predicted to be involved in vasculogenesis. Predicted to be active in cell surface and extracellular region. [provided by Alliance of Genome Resources, Jul 2025] | 6 | 32164595 | 32168281 | Human | 40 | symbol , old_gene_name , COSMIC , name , Human Proteome Map | gene, protein-coding, VALIDATED [RefSeq] |
| 9046756 | Egfl8 | EGF like domain multiple 8 | INVOLVED IN in utero embryonic development (ortholog) | NW_004955437 | 630099 | 633592 | Chinchilla | 2 | symbol , old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 11900369 | EGFL8 | EGF like domain multiple 8 | ENCODES a protein that exhibits calcium ion binding (inferred); signaling receptor binding (inferred); INVOLVED IN in utero embryonic development (ortholog); FOUND IN cell surface (inferred); extracellular region (inferred) | 6 | 31811944 | 31815796 | Bonobo | 7 | symbol , name | gene, protein-coding, MODEL [RefSeq] |
| 12363922 | EGFL8 | EGF like domain multiple 8 | ENCODES a protein that exhibits calcium ion binding (inferred); INVOLVED IN in utero embryonic development (ortholog); FOUND IN extracellular region (inferred) | 12 | 1558069 | 1561566 | Dog | 4 | symbol , name | gene, protein-coding, MODEL [RefSeq] |
| 14117419 | EGFL8 | EGF like domain multiple 8 | ENCODES a protein that exhibits calcium ion binding (inferred); INVOLVED IN in utero embryonic development (ortholog); FOUND IN extracellular region (inferred) | | | | Pig | 8 | symbol , old_gene_name , name | gene, protein-coding, PROVISIONAL [RefSeq] |
| 18711922 | EGFL8 | EGF like domain multiple 8 | ENCODES a protein that exhibits calcium ion binding (inferred); signaling receptor binding (inferred); INVOLVED IN in utero embryonic development (ortholog); FOUND IN cell surface (inferred); extracellular region (inferred) | | | | Green Monkey | 7 | symbol , name | gene, protein-coding, MODEL [RefSeq] |
| 18920960 | Egfl8 | EGF like domain multiple 8 | ENCODES a protein that exhibits calcium ion binding (inferred); signaling receptor binding (inferred); INVOLVED IN in utero embryonic development (ortholog); FOUND IN cell surface (inferred); extracellular region (inferred) | | | | Naked Mole-Rat | 7 | symbol , name | gene, protein-coding, MODEL [RefSeq] |
| 625939650 | Egfl8 | EGF like domain multiple 8 | INVOLVED IN in utero embryonic development (ortholog) | | | | Black Rat | 2 | symbol , name | gene, protein-coding, MODEL [RefSeq] |
| 1557004 | Egfl6 | EGF-like-domain, multiple 6 | Predicted to enable calcium ion binding activity. Acts upstream of or within extracellular matrix organization and positive regulation of cell-substrate adhesion. Located in basement membrane. Is expressed in several structures, including alimentary system; genitourinary system; limb; lung; and skin . Orthologous to human EGFL6 (EGF like domain multiple 6). [provided by Alliance of Genome Resources, Jul 2025] | X | 165306003 | 165368712 | Mouse | 93 | symbol , old_gene_name , PhenoGen , name , description | gene, protein-coding, VALIDATED [RefSeq] |
| 1563321 | Egfl6 | EGF-like-domain, multiple 6 | ENCODES a protein that exhibits calcium ion binding (inferred); INVOLVED IN extracellular matrix organization (ortholog); positive regulation of cell-substrate adhesion (ortholog); ASSOCIATED WITH bladder exstrophy-epispadias-cloacal exstrophy complex (ortholog); FOUND IN basement membrane (ortholog ); extracellular matrix (ortholog); INTERACTS WITH 1-naphthyl isothiocyanate; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine | X | 31515752 | 31573699 | Rat | 91 | symbol , PhenoGen , name | gene, protein-coding, PROVISIONAL [RefSeq] |
| 708507 | Egfl7 | EGF-like-domain, multiple 7 | ENCODES a protein that exhibits Notch binding (ortholog); INVOLVED IN blood vessel development (ortholog); negative regulation of cell migration (ortholog); negative regulation of Notch signaling pathway (ortholog); ASSOCIATED WITH developmental and epileptic encephalopathy 14 (ortholog); FOUND IN e xtracellular region (ortholog); extracellular space (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 3H-1,2-dithiole-3-thione; aflatoxin B1 | 3 | 29802481 | 29814966 | Rat | 119 | symbol , old_gene_name , PhenoGen , name | gene, protein-coding, VALIDATED [RefSeq] |
| 1549706 | Egfl8 | EGF-like-domain, multiple 8 | ENCODES a protein that exhibits calcium ion binding (inferred); INVOLVED IN in utero embryonic development (ortholog); FOUND IN extracellular region (inferred); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,6-dinitrotoluene; 4-amino-2,6-dinitrotoluene | 20 | 4137531 | 4140632 | Rat | 41 | symbol , old_gene_name , PhenoGen , name | gene, protein-coding, VALIDATED [RefSeq] |
| 621188 | Megf6 | multiple EGF-like-domains 6 | ENCODES a protein that exhibits calcium ion binding (inferred); scavenger receptor activity (inferred); INVOLVED IN vesicle-mediated transport (inferred); FOUND IN extracellular region (inferred); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 7,12-dimethyltetraphene; ammonium chloride | 5 | 170020699 | 170121557 | Rat | 110 | symbol , old_gene_name , PhenoGen , name , old_gene_symbol | gene, protein-coding, PROVISIONAL [RefSeq] |
| 736662 | MEGF6 | multiple EGF like domains 6 | Predicted to enable calcium ion binding activity and scavenger receptor activity. Predicted to be involved in vesicle-mediated transport. Predicted to be located in extracellular region. [provided by Alliance of Genome Resources, Jul 2025] | 1 | 3487951 | 3624786 | Human | 110 | symbol , old_gene_name , COSMIC , name , Human Proteome Map , old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 736663 | Megf6 | multiple EGF-like-domains 6 | Predicted to enable calcium ion binding activity and scavenger receptor activity. Predicted to be involved in vesicle-mediated transport. Located in collagen-containing extracellular matrix. Is expressed in several structures, including embryo mesenchyme; head bone; intraembryonic coelom; pharyngo-t ympanic tube; and submandibular gland primordium. Orthologous to human MEGF6 (multiple EGF like domains 6). [provided by Alliance of Genome Resources, Apr 2025] | 4 | 154255156 | 154360178 | Mouse | 117 | symbol , old_gene_name , PhenoGen , name , description , old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 8956975 | Megf6 | multiple EGF like domains 6 | | NW_004955486 | 8029200 | 8103395 | Chinchilla | 1 | symbol , old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 12106647 | MEGF6 | multiple EGF like domains 6 | ENCODES a protein that exhibits calcium ion binding (inferred); scavenger receptor activity (inferred); INVOLVED IN vesicle-mediated transport (inferred); FOUND IN extracellular region (inferred) | 5 | 58058833 | 58145855 | Dog | 7 | symbol , name | gene, protein-coding, MODEL [RefSeq] |
| 12713616 | Megf6 | multiple EGF like domains 6 | | NW_004936737 | 269629 | 364809 | Squirrel | 1 | symbol , name | gene, protein-coding, MODEL [RefSeq] |
| 14203205 | MEGF6 | multiple EGF like domains 6 | ENCODES a protein that exhibits calcium ion binding (inferred); INVOLVED IN vesicle-mediated transport (inferred); FOUND IN extracellular region (inferred); INTERACTS WITH deoxynivalenol | | | | Pig | 7 | symbol , name | gene, protein-coding, MODEL [RefSeq] |
| 18912013 | Megf6 | multiple EGF like domains 6 | ENCODES a protein that exhibits calcium ion binding (inferred); scavenger receptor activity (inferred); INVOLVED IN heterophilic cell-cell adhesion (inferred); vesicle-mediated transport (inferred) | | | | Naked Mole-Rat | 6 | symbol , name | gene, protein-coding, MODEL [RefSeq] |
| 152178121 | MEGF6 | multiple EGF like domains 6 | | | | | Naked Mole-Rat | | symbol , name | gene, protein-coding |
| 625931104 | Megf6 | multiple EGF like domains 6 | | | | | Black Rat | 1 | symbol , name | gene, protein-coding, MODEL [RefSeq] |
| 621190 | Megf8 | multiple EGF-like-domains 8 | ENCODES a protein that exhibits calcium ion binding (inferred); INVOLVED IN aorta development (ortholog); BMP signaling pathway (ortholog); cell migration involved in gastrulation (ortholog); ASSOCIATED WITH Carpenter syndrome (ortholog); Carpenter syndrome 2 (ortholog); craniosynostosis (ortholog); FOUND IN nucleus (ortholog); ubiquitin ligase complex (ortholog); INTERACTS WITH amitrole; ammonium chloride; beta-naphthoflavone | 1 | 90030057 | 90079423 | Rat | 145 | symbol , old_gene_name , PhenoGen , name , old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 737434 | MEGF8 | multiple EGF like domains 8 | The protein encoded by this gene is a single-pass type I membrane protein of unknown function that contains several EGF-like domains, Kelch repeats, and PSI domains. Defects in this gene are a cause of Carpenter syndrome 2. Two transcript variants encoding diffe rent isoforms have been found for this gene. [provided by RefSeq, Dec 2012] | 19 | 42325635 | 42378765 | Human | 294 | symbol , old_gene_name , COSMIC , name , description , Human Proteome Map , old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 737435 | Megf8 | multiple EGF-like-domains 8 | Predicted to enable calcium ion binding activity. Involved in several processes, including BMP signaling pathway; embryonic organ development; and fasciculation of sensory neuron axon. Acts upstream of or within several processes, including circulatory system development; determination of digestive tract left/right asymmetry; and embryonic brain development. Located in nucleus. Part of ubiquitin ligase complex. Is expressed in several structures, including branchial arch; ganglia; heart; limb bud; and telencephalon. Used to study Carpenter syndrome and visceral heterotaxy. Human ortholog(s) of this gene implicated in Carpenter syndrome 2. Orthologous to human MEGF8 (multiple EGF like domains 8). [provided by Alliance of Genome Resources, Jul 2025] | 7 | 25016589 | 25065342 | Mouse | 216 | symbol , old_gene_name , PhenoGen , name , description , old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 8806032 | Megf8 | multiple EGF like domains 8 | INVOLVED IN aorta development (ortholog); BMP signaling pathway (ortholog); cell migration involved in gastrulation (ortholog); ASSOCIATED WITH Carpenter syndrome (ortholog); Carpenter syndrome 2 (ortholog); craniosynostosis (ortholog); FOUND IN nucleus (ortholog); ubiquitin ligase complex (ortholog ) | NW_004955555 | 549921 | 591978 | Chinchilla | 47 | symbol , old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 11946476 | MEGF8 | multiple EGF like domains 8 | ENCODES a protein that exhibits calcium ion binding (inferred); INVOLVED IN aorta development (ortholog); coronary vasculature development (ortholog); determination of digestive tract left/right asymmetry (ortholog); ASSOCIATED WITH Carpenter syndrome (ortholog); Carpenter syndrome 2 (ortholog); cra niosynostosis (ortholog); FOUND IN ubiquitin ligase complex (ortholog) | 19 | 39213339 | 39265391 | Bonobo | 54 | symbol , name | gene, protein-coding, MODEL [RefSeq] |
| 12238168 | MEGF8 | multiple EGF like domains 8 | ENCODES a protein that exhibits calcium ion binding (inferred); INVOLVED IN aorta development (ortholog); BMP signaling pathway (ortholog); cell migration involved in gastrulation (ortholog); ASSOCIATED WITH Carpenter syndrome (ortholog); Carpenter syndrome 2 (ortholog); craniosynostosis (ortholog); FOUND IN nucleus (ortholog); ubiquitin ligase complex (ortholog) | 1 | 112020344 | 112063120 | Dog | 52 | symbol , name | gene, protein-coding, MODEL [RefSeq] |
| 12527184 | Megf8 | multiple EGF like domains 8 | ENCODES a protein that exhibits calcium ion binding (inferred); INVOLVED IN aorta development (ortholog); BMP signaling pathway (ortholog); coronary vasculature development (ortholog); ASSOCIATED WITH Carpenter syndrome (ortholog); Carpenter syndrome 2 (ortholog); craniosynostosis (ortholog); FOUND IN nucleus (ortholog); ubiquitin ligase complex (ortholog) | NW_004936706 | 157167 | 198071 | Squirrel | 66 | symbol , name | gene, protein-coding, MODEL [RefSeq] |
| 14133633 | MEGF8 | multiple EGF like domains 8 | ENCODES a protein that exhibits calcium ion binding (inferred); INVOLVED IN aorta development (ortholog); BMP signaling pathway (ortholog); cell migration involved in gastrulation (ortholog); ASSOCIATED WITH Carpenter syndrome (ortholog); Carpenter syndrome 2 (ortholog); craniosynostosis (ortholog); FOUND IN nucleus (ortholog); ubiquitin ligase complex (ortholog); INTERACTS WITH deoxynivalenol | | | | Pig | 53 | symbol , name | gene, protein-coding, MODEL [RefSeq] |
| 18779444 | MEGF8 | multiple EGF like domains 8 | ENCODES a protein that exhibits calcium ion binding (inferred); INVOLVED IN aorta development (ortholog); coronary vasculature development (ortholog); determination of digestive tract left/right asymmetry (ortholog); ASSOCIATED WITH Carpenter syndrome (ortholog); Carpenter syndrome 2 (ortholog); cra niosynostosis (ortholog); FOUND IN ubiquitin ligase complex (ortholog) | | | | Green Monkey | 54 | symbol , name | gene, protein-coding, MODEL [RefSeq] |
| 18915068 | Megf8 | multiple EGF like domains 8 | ENCODES a protein that exhibits calcium ion binding (inferred); INVOLVED IN aorta development (ortholog); BMP signaling pathway (ortholog); cell migration involved in gastrulation (ortholog); ASSOCIATED WITH Carpenter syndrome (ortholog); Carpenter syndrome 2 (ortholog); craniosynostosis (ortholog); FOUND IN nucleus (ortholog); ubiquitin ligase complex (ortholog) | | | | Naked Mole-Rat | 53 | symbol , name | gene, protein-coding, MODEL [RefSeq] |
| 625847843 | Megf8 | multiple EGF like domains 8 | INVOLVED IN aorta development (ortholog); BMP signaling pathway (ortholog); cell migration involved in gastrulation (ortholog); ASSOCIATED WITH Carpenter syndrome (ortholog); Carpenter syndrome 2 (ortholog); craniosynostosis (ortholog); FOUND IN nucleus (ortholog); ubiquitin ligase complex (ortholog ) | | | | Black Rat | 47 | symbol , name | gene, protein-coding, MODEL [RefSeq] |
| 1308330 | Megf9 | multiple EGF-like-domains 9 | FOUND IN basement membrane (ortholog); INTERACTS WITH 17alpha-ethynylestradiol; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine | 5 | 89008679 | 89120731 | Rat | 86 | symbol , old_gene_name , PhenoGen , name , old_gene_symbol | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1318038 | Megf9 | multiple EGF-like-domains 9 | Predicted to be involved in several processes, including axon guidance; basement membrane assembly; and substrate adhesion-dependent cell spreading. Located in basement membrane. Is expressed in several structures, including eye; gut epithelium; nervous system; olfactory epithelium; and skin. Orthol ogous to human MEGF9 (multiple EGF like domains 9). [provided by Alliance of Genome Resources, Jul 2025] | 4 | 70350164 | 70453165 | Mouse | 85 | symbol , old_gene_name , PhenoGen , name , description , old_gene_symbol | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1342735 | MEGF9 | multiple EGF like domains 9 | Predicted to be located in basement membrane and membrane. [provided by Alliance of Genome Resources, Jul 2025] | 9 | 120600811 | 120714470 | Human | 78 | symbol , old_gene_name , COSMIC , name , Human Proteome Map , old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 9026634 | Megf9 | multiple EGF like domains 9 | FOUND IN basement membrane (ortholog) | NW_004955419 | 7303248 | 7399796 | Chinchilla | 1 | symbol , old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 12004336 | MEGF9 | multiple EGF like domains 9 | ENCODES a protein that exhibits extracellular matrix structural constituent (inferred); INVOLVED IN animal organ morphogenesis (inferred); axon guidance (inferred); blood vessel morphogenesis (inferred); FOUND IN basement membrane (inferred); membrane (inferred) | 9 | 91728219 | 91842056 | Bonobo | 9 | symbol , name | gene, protein-coding, MODEL [RefSeq] |
| 12377963 | MEGF9 | multiple EGF like domains 9 | FOUND IN basement membrane (ortholog) | 11 | 73716395 | 73793072 | Dog | 1 | symbol , name | gene, protein-coding, MODEL [RefSeq] |
| 12737423 | Megf9 | multiple EGF like domains 9 | FOUND IN basement membrane (ortholog) | NW_004936487 | 9095979 | 9203768 | Squirrel | 1 | symbol , name | gene, protein-coding, MODEL [RefSeq] |
| 14147243 | MEGF9 | multiple EGF like domains 9 | FOUND IN basement membrane (inferred); membrane (inferred) | | | | Pig | 9 | symbol , name | gene, protein-coding, MODEL [RefSeq] |
| 18790750 | MEGF9 | multiple EGF like domains 9 | ENCODES a protein that exhibits extracellular matrix structural constituent (inferred); INVOLVED IN animal organ morphogenesis (inferred); axon guidance (inferred); blood vessel morphogenesis (inferred); FOUND IN basement membrane (inferred); membrane (inferred) | | | | Green Monkey | 9 | symbol , name | gene, protein-coding, MODEL [RefSeq] |
| 18932408 | Megf9 | multiple EGF like domains 9 | INVOLVED IN animal organ morphogenesis (inferred); tissue development (inferred); FOUND IN basement membrane (inferred); membrane (inferred) | | | | Naked Mole-Rat | 4 | symbol , name | gene, protein-coding, MODEL [RefSeq] |
| 626154600 | Megf9 | multiple EGF like domains 9 | FOUND IN basement membrane (ortholog) | | | | Black Rat | 1 | symbol , name | gene, protein-coding, MODEL [RefSeq] |
| 735084 | Megf10 | multiple EGF-like domains 10 | ENCODES a protein that exhibits complement component C1q complex binding (ortholog); Notch binding (ortholog); scavenger receptor activity (ortholog); INVOLVED IN apoptotic process involved in development (ortholog); engulfment of apoptotic cell (ortholog); homotypic cell-cell adhesion (ortholog); A SSOCIATED WITH congenital myopathy 10B (ortholog); Deglutition Disorders (ortholog); early-onset myopathy-areflexia-respiratory distress-dysphagia syndrome (ortholog); FOUND IN phagocytic cup (ortholog); plasma membrane (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; ammonium chloride | 18 | 52803292 | 52953431 | Rat | 144 | symbol , PhenoGen , name | gene, protein-coding, VALIDATED [RefSeq] |
| 1558549 | Megf10 | multiple EGF-like-domains 10 | Enables Notch binding activity. Involved in several processes, including myoblast development; positive regulation of myoblast proliferation; and skeletal muscle satellite cell proliferation. Acts upstream of or within apoptotic process involved in development; engulfment of apoptotic cell; and reco gnition of apoptotic cell. Located in phagocytic cup. Is expressed in several structures, including brain; heart; retina layer; skeletal muscle tissue; and testis. Human ortholog(s) of this gene implicated in congenital myopathy 10B and early-onset myopathy-areflexia-respiratory distress-dysphagia syndrome. Orthologous to human MEGF10 (multiple EGF like domains 10). [provided by Alliance of Genome Resources, Jul 2025] | 18 | 57266162 | 57430539 | Mouse | 143 | symbol , old_gene_name , PhenoGen , name , description | gene, protein-coding, VALIDATED [RefSeq] |
| 1601732 | MEGF10 | multiple EGF like domains 10 | This gene encodes a member of the multiple epidermal growth factor-like domains protein family. The encoded protein plays a role in cell adhesion, motility and proliferation, and is a critical mediator of apoptotic cell phagocytosis as well as amyloid-beta peptide uptake in the brain. Expression of this gene may be associated with schizophrenia, and mutations in this gene are a cause of early-onset myopathy, areflexia, respiratory distress, and dysphagia (EMARDD) as well as congenital myopathy with minicores. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Apr 2012] | 5 | 127229300 | 127461222 | Human | 228 | symbol , old_gene_name , COSMIC , name , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 8988044 | Megf10 | multiple EGF like domains 10 | ENCODES a protein that exhibits complement component C1q complex binding (ortholog); Notch binding (ortholog); scavenger receptor activity (ortholog); INVOLVED IN apoptotic process involved in development (ortholog); engulfment of apoptotic cell (ortholog); homotypic cell-cell adhesion (ortholog); A SSOCIATED WITH congenital myopathy 10B (ortholog); Deglutition Disorders (ortholog); early-onset myopathy-areflexia-respiratory distress-dysphagia syndrome (ortholog); FOUND IN phagocytic cup (ortholog); plasma membrane (ortholog) | NW_004955415 | 393642 | 513157 | Chinchilla | 33 | symbol , old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 11674886 | MEGF10 | multiple EGF like domains 10 | ENCODES a protein that exhibits complement component C1q complex binding (inferred); Notch binding (inferred); scavenger receptor activity (inferred); INVOLVED IN apoptotic process involved in development (ortholog); engulfment of apoptotic cell (ortholog); recognition of apoptotic cell (ortholog); ASSOCIATED WITH congenital myopathy 10B (ortholog); Deglutition Disorders (ortholog); early-onset myopathy-areflexia-respiratory distress-dysphagia syndrome (ortholog); FOUND IN membrane (inferred); phagocytic cup (inferred); plasma membrane (inferred) | 5 | 122639155 | 122877324 | Bonobo | 42 | symbol , name | gene, protein-coding, MODEL [RefSeq] |
| 12339532 | MEGF10 | multiple EGF like domains 10 | ENCODES a protein that exhibits complement component C1q complex binding (inferred); Notch binding (inferred); scavenger receptor activity (inferred); INVOLVED IN apoptotic process involved in development (ortholog); engulfment of apoptotic cell (ortholog); recognition of apoptotic cell (ortholog); ASSOCIATED WITH congenital myopathy 10B (ortholog); Deglutition Disorders (ortholog); early-onset myopathy-areflexia-respiratory distress-dysphagia syndrome (ortholog); FOUND IN phagocytic cup (inferred); plasma membrane (inferred) | 11 | 16359648 | 16574882 | Dog | 47 | symbol , name | gene, protein-coding, MODEL [RefSeq] |
| 12567366 | Megf10 | multiple EGF like domains 10 | ENCODES a protein that exhibits complement component C1q complex binding (inferred); Notch binding (inferred); scavenger receptor activity (inferred); INVOLVED IN apoptotic process involved in development (ortholog); engulfment of apoptotic cell (ortholog); recognition of apoptotic cell (ortholog); ASSOCIATED WITH congenital myopathy 10B (ortholog); Deglutition Disorders (ortholog); early-onset myopathy-areflexia-respiratory distress-dysphagia syndrome (ortholog); FOUND IN membrane (inferred); phagocytic cup (inferred); plasma membrane (inferred) | NW_004936504 | 634167 | 753438 | Squirrel | 42 | symbol , old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 13921442 | MEGF10 | multiple EGF like domains 10 | ENCODES a protein that exhibits complement component C1q complex binding (inferred); Notch binding (inferred); scavenger receptor activity (inferred); INVOLVED IN apoptotic process involved in development (ortholog); engulfment of apoptotic cell (ortholog); recognition of apoptotic cell (ortholog); ASSOCIATED WITH congenital myopathy 10B (ortholog); Deglutition Disorders (ortholog); early-onset myopathy-areflexia-respiratory distress-dysphagia syndrome (ortholog); FOUND IN phagocytic cup (inferred); plasma membrane (inferred); INTERACTS WITH deoxynivalenol | | | | Pig | 51 | symbol , name | gene, protein-coding, MODEL [RefSeq] |
| 18788158 | MEGF10 | multiple EGF like domains 10 | ENCODES a protein that exhibits complement component C1q complex binding (inferred); Notch binding (inferred); scavenger receptor activity (inferred); INVOLVED IN apoptotic process involved in development (ortholog); engulfment of apoptotic cell (ortholog); recognition of apoptotic cell (ortholog); ASSOCIATED WITH congenital myopathy 10B (ortholog); Deglutition Disorders (ortholog); early-onset myopathy-areflexia-respiratory distress-dysphagia syndrome (ortholog); FOUND IN membrane (inferred); phagocytic cup (inferred); plasma membrane (inferred) | | | | Green Monkey | 42 | symbol , name | gene, protein-coding, MODEL [RefSeq] |
| 18911993 | Megf10 | multiple EGF like domains 10 | ENCODES a protein that exhibits complement component C1q complex binding (ortholog); scavenger receptor activity (ortholog); INVOLVED IN apoptotic process involved in development (ortholog); engulfment of apoptotic cell (ortholog); homotypic cell-cell adhesion (ortholog); ASSOCIATED WITH congenital myopathy 10B (ortholog); Deglutition Disorders (ortholog); early-onset myopathy-areflexia-respiratory distress-dysphagia syndrome (ortholog); FOUND IN membrane (inferred); phagocytic cup (inferred); plasma membrane (inferred) | | | | Naked Mole-Rat | 35 | symbol , name | gene, protein-coding, MODEL [RefSeq] |
| 626037433 | Megf10 | multiple EGF like domains 10 | ENCODES a protein that exhibits complement component C1q complex binding (ortholog); Notch binding (ortholog); scavenger receptor activity (ortholog); INVOLVED IN apoptotic process involved in development (ortholog); engulfment of apoptotic cell (ortholog); homotypic cell-cell adhesion (ortholog); A SSOCIATED WITH congenital myopathy 10B (ortholog); Deglutition Disorders (ortholog); early-onset myopathy-areflexia-respiratory distress-dysphagia syndrome (ortholog); FOUND IN phagocytic cup (ortholog); plasma membrane (ortholog) | | | | Black Rat | 33 | symbol , name | gene, protein-coding, MODEL [RefSeq] |
| 1557497 | Megf11 | multiple EGF-like-domains 11 | Predicted to enable scavenger receptor activity. Involved in homotypic cell-cell adhesion and retina layer formation. Predicted to be located in basolateral plasma membrane. Is expressed in heart; nervous system; and retina layer. Orthologous to human MEGF11 (mu ltiple EGF like domains 11). [provided by Alliance of Genome Resources, Jul 2025] | 9 | 64291556 | 64618584 | Mouse | 68 | symbol , old_gene_name , PhenoGen , name , description | gene, protein-coding, VALIDATED [RefSeq] |
| 1582797 | Megf11 | multiple EGF-like-domains 11 | ENCODES a protein that exhibits scavenger receptor activity (inferred); INVOLVED IN homotypic cell-cell adhesion (ortholog); retina layer formation (ortholog); FOUND IN plasma membrane (inferred); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; acrylamide | 8 | 73787568 | 74113228 | Rat | 63 | symbol , old_gene_name , PhenoGen , name | gene, protein-coding, VALIDATED [RefSeq] |
| 1603600 | MEGF11 | multiple EGF like domains 11 | Predicted to be involved in homotypic cell-cell adhesion and retina layer formation. Predicted to be located in basolateral plasma membrane. [provided by Alliance of Genome Resources, Jul 2025] | 15 | 65895299 | 66253750 | Human | 64 | symbol , old_gene_name , COSMIC , name , Human Proteome Map | gene, protein-coding, VALIDATED [RefSeq] |
| 8875185 | Megf11 | multiple EGF like domains 11 | INVOLVED IN homotypic cell-cell adhesion (ortholog); retina layer formation (ortholog) | NW_004955450 | 9355134 | 9634747 | Chinchilla | 3 | symbol , old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 11718077 | MEGF11 | multiple EGF like domains 11 | INVOLVED IN homotypic cell-cell adhesion (inferred); retina layer formation (inferred); FOUND IN membrane (inferred); plasma membrane (inferred) | 15 | 44836750 | 45208674 | Bonobo | 5 | symbol , name | gene, protein-coding, MODEL [RefSeq] |
| 12221927 | MEGF11 | multiple EGF like domains 11 | INVOLVED IN homotypic cell-cell adhesion (ortholog); retina layer formation (ortholog); FOUND IN plasma membrane (inferred) | 30 | 30224538 | 30561565 | Dog | 4 | symbol , name | gene, protein-coding, MODEL [RefSeq] |
| 12693284 | Megf11 | multiple EGF like domains 11 | INVOLVED IN homotypic cell-cell adhesion (inferred); retina layer formation (inferred); FOUND IN basolateral plasma membrane (inferred); membrane (inferred); plasma membrane (inferred) | NW_004936471 | 26119146 | 26437057 | Squirrel | 6 | symbol , old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 13991616 | MEGF11 | multiple EGF like domains 11 | INVOLVED IN homotypic cell-cell adhesion (inferred); retina layer formation (inferred); FOUND IN basolateral plasma membrane (inferred); plasma membrane (inferred) | | | | Pig | 9 | symbol , old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 18364186 | MEGF11 | multiple EGF like domains 11 | INVOLVED IN homotypic cell-cell adhesion (ortholog); retina layer formation (ortholog) | | | | Green Monkey | 3 | symbol , name | gene, protein-coding, MODEL [RefSeq] |
| 18906542 | Megf11 | multiple EGF like domains 11 | INVOLVED IN homotypic cell-cell adhesion (ortholog); retina layer formation (ortholog); FOUND IN basolateral plasma membrane (inferred); membrane (inferred); plasma membrane (inferred) | | | | Naked Mole-Rat | 6 | symbol , name | gene, protein-coding, MODEL [RefSeq] |
| 20866954 | MEGF11 | multiple EGF like domains 11 | INVOLVED IN homotypic cell-cell adhesion (inferred); retina layer formation (inferred); FOUND IN membrane (inferred); plasma membrane (inferred) | | | | Green Monkey | 4 | symbol , name | gene, protein-coding |
| 626003445 | Megf11 | multiple EGF like domains 11 | INVOLVED IN homotypic cell-cell adhesion (ortholog); retina layer formation (ortholog) | | | | Black Rat | 3 | symbol , name | gene, protein-coding, MODEL [RefSeq] |
| 1352791 | CRIPTO | cripto, EGF-CFC family member | This gene encodes an epidermal growth factor-related protein that contains a cripto, FRL-1, and cryptic domain. The encoded protein is an extracellular, membrane-bound signaling protein that plays an essential role in embryonic development and tumor growth. Mutations in this gene are associated with forebrain defects. Pseudogenes of this gene are found on chromosomes 2, 3, 6, 8, 19 and X. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010] | 3 | 46574535 | 46582457 | Human | 244 | name | gene, protein-coding, REVIEWED [RefSeq] |
| 1594185 | Cripto | cripto, EGF-CFC family member | ENCODES a protein that exhibits coreceptor activity (ortholog); growth factor activity (ortholog); nodal binding (ortholog); INVOLVED IN anterior/posterior axis specification (ortholog); anterior/posterior axis specification, embryo (ortholog); cardiac muscle cell differentiation (ortholog); PARTICI PATES IN glypican signaling pathway; ASSOCIATED WITH colon cancer (ortholog); congenital heart disease (ortholog); Forebrain Defects (ortholog); FOUND IN apical plasma membrane (ortholog); cell surface (ortholog); cytoplasm (ortholog); INTERACTS WITH trichloroethene; 1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene (ortholog); 2,2',4,4',5,5'-hexachlorobiphenyl (ortholog) | 8 | 119803182 | 119808714 | Rat | 121 | name | gene, protein-coding, VALIDATED [RefSeq] |
| 1617601 | Cripto | cripto, EGF-CFC family member | Enables several functions, including Wnt-protein binding activity; coreceptor activity; and nodal binding activity. Involved in several processes, including morphogenesis of a branching structure; nodal signaling pathway; and positive regulation of cell migration. Acts upstream of or within several processes, including circulatory system development; negative regulation of transforming growth factor beta receptor signaling pathway; and positive regulation of fibroblast proliferation. Located in several cellular components, including Golgi apparatus; cell surface; and perinuclear region of cytoplasm. Is expressed in several structures, including blastocyst; brain; extraembryonic component; gonad; and heart. Human ortholog(s) of this gene implicated in colon cancer and congenital heart disease. Orthologous to several human genes including CRIPTO (cripto, EGF-CFC family member). [provided by Alliance of Genome Resources, Jul 2025] | 9 | 110768676 | 110775226 | Mouse | 194 | name , description | gene, protein-coding, VALIDATED [RefSeq] |
| 8830919 | Cripto | cripto, EGF-CFC family member | ENCODES a protein that exhibits coreceptor activity (ortholog); growth factor activity (ortholog); nodal binding (ortholog); INVOLVED IN anterior/posterior axis specification (ortholog); anterior/posterior axis specification, embryo (ortholog); cardiac muscle cell differentiation (ortholog); PARTICI PATES IN glypican signaling pathway; ASSOCIATED WITH colon cancer (ortholog); congenital heart disease (ortholog); Forebrain Defects (ortholog); FOUND IN apical plasma membrane (ortholog); cell surface (ortholog); cytoplasm (ortholog) | NW_004955420 | 25476975 | 25479969 | Chinchilla | 64 | name | gene, protein-coding, MODEL [RefSeq] |
| 11813099 | CRIPTO | cripto, EGF-CFC family member | ENCODES a protein that exhibits coreceptor activity (ortholog); nodal binding (ortholog); type I activin receptor binding (ortholog); INVOLVED IN anterior/posterior axis specification (ortholog); anterior/posterior axis specification, embryo (ortholog); cardiac muscle cell differentiation (ortholog) ; PARTICIPATES IN glypican signaling pathway; ASSOCIATED WITH colon cancer (ortholog); congenital heart disease (ortholog); Forebrain Defects (ortholog); FOUND IN cytoplasm (ortholog); extracellular region (ortholog); Golgi apparatus (ortholog) | 3 | 46473282 | 46478454 | Bonobo | 66 | name | gene, protein-coding, MODEL [RefSeq] |
| 12151134 | CRIPTO | cripto, EGF-CFC family member | ENCODES a protein that exhibits coreceptor activity (ortholog); growth factor activity (ortholog); signaling receptor binding (ortholog); INVOLVED IN anterior/posterior axis specification (ortholog); anterior/posterior axis specification, embryo (ortholog); cardiac muscle cell differentiation (ortho log); PARTICIPATES IN glypican signaling pathway; ASSOCIATED WITH colon cancer (ortholog); congenital heart disease (ortholog); Forebrain Defects (ortholog); FOUND IN apical plasma membrane (ortholog); cell surface (ortholog); cytoplasm (ortholog) | 20 | 42137939 | 42140590 | Dog | 69 | name | gene, protein-coding, MODEL [RefSeq] |
| 12457587 | Cripto | cripto, EGF-CFC family member | ENCODES a protein that exhibits growth factor activity (ortholog); signaling receptor binding (ortholog); INVOLVED IN anterior/posterior axis specification (ortholog); anterior/posterior axis specification, embryo (ortholog); cardiac muscle cell differentiation (ortholog); PARTICIPATES IN glypican s ignaling pathway; ASSOCIATED WITH colon cancer (ortholog); congenital heart disease (ortholog); Forebrain Defects (ortholog); FOUND IN apical plasma membrane (ortholog); membrane raft (ortholog) | NW_004936596 | 451483 | 453892 | Squirrel | 61 | name | gene, protein-coding, MODEL [RefSeq] |
| 14216004 | CRIPTO | cripto, EGF-CFC family member | ENCODES a protein that exhibits signaling receptor binding (ortholog); INVOLVED IN anterior/posterior axis specification (ortholog); anterior/posterior axis specification, embryo (ortholog); cardiac muscle cell differentiation (ortholog); PARTICIPATES IN glypican signaling pathway; ASSOCIATED WITH c olon cancer (ortholog); congenital heart disease (ortholog); Forebrain Defects (ortholog); FOUND IN apical plasma membrane (ortholog); membrane raft (ortholog) | | | | Pig | 72 | name | gene, protein-coding, MODEL [RefSeq] |
| 18523360 | CRIPTO | cripto, EGF-CFC family member | ENCODES a protein that exhibits signaling receptor binding (ortholog); INVOLVED IN anterior/posterior axis specification (ortholog); anterior/posterior axis specification, embryo (ortholog); cardiac muscle cell differentiation (ortholog); PARTICIPATES IN glypican signaling pathway; ASSOCIATED WITH c olon cancer (ortholog); congenital heart disease (ortholog); Forebrain Defects (ortholog); FOUND IN apical plasma membrane (ortholog); membrane raft (ortholog) | | | | Green Monkey | 63 | name | gene, protein-coding, MODEL [RefSeq] |
| 18923093 | Cripto | cripto, EGF-CFC family member | ENCODES a protein that exhibits coreceptor activity (ortholog); growth factor activity (ortholog); nodal binding (ortholog); INVOLVED IN anterior/posterior axis specification (ortholog); anterior/posterior axis specification, embryo (ortholog); cardiac muscle cell differentiation (ortholog); PARTICI PATES IN glypican signaling pathway; ASSOCIATED WITH colon cancer (ortholog); congenital heart disease (ortholog); Forebrain Defects (ortholog); FOUND IN apical plasma membrane (ortholog); cell surface (ortholog); cytoplasm (ortholog) | | | | Naked Mole-Rat | 64 | name | gene, protein-coding, MODEL [RefSeq] |
| 626096390 | Cripto | cripto, EGF-CFC family member | ENCODES a protein that exhibits coreceptor activity (ortholog); growth factor activity (ortholog); nodal binding (ortholog); INVOLVED IN anterior/posterior axis specification (ortholog); anterior/posterior axis specification, embryo (ortholog); cardiac muscle cell differentiation (ortholog); PARTICI PATES IN glypican signaling pathway; ASSOCIATED WITH colon cancer (ortholog); congenital heart disease (ortholog); Forebrain Defects (ortholog); FOUND IN apical plasma membrane (ortholog); cell surface (ortholog); cytoplasm (ortholog) | | | | Black Rat | 64 | name | gene, protein-coding, MODEL [RefSeq] |
| 1347488 | CRIPTO3 | cripto, EGF-CFC family member 3 | The TDGF3 locus has characteristics of a retrotransposon, including lack of introns and a poly(A) sequence. [provided by RefSeq, Jul 2008] | X | 110520896 | 110523021 | Human | 24 | name | gene, protein-coding, VALIDATED [RefSeq] |
| 11700362 | CRIPTO3 | cripto, EGF-CFC family member 3 | ENCODES a protein that exhibits growth factor activity (inferred); INVOLVED IN signal transduction (inferred); ASSOCIATED WITH autistic disorder (ortholog); FOUND IN plasma membrane (inferred) | X | 99628286 | 99629441 | Bonobo | 5 | name | gene, protein-coding, MODEL [RefSeq] |
| 1353993 | CFC1 | cryptic, EGF-CFC family member 1 | This gene encodes a member of the epidermal growth factor (EGF)- Cripto, Frl-1, and Cryptic (CFC) family, which are involved in signalling during embryonic development. Proteins in this family share a variant EGF-like motif, a conserved cysteine-rich domain, and a C-terminal hydrophobic region. The protein encoded by this gene is necessary for patterning the left-right embryonic axis. Mutations in this gene are associated with defects in organ development, including autosomal visceral heterotaxy and congenital heart disease. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012] | 2 | 130592165 | 130599575 | Human | 56 | name , description | gene, protein-coding, REVIEWED [RefSeq] |
| 1557732 | Cfc1 | cryptic, EGF-CFC family member 1 | Enables activin receptor binding activity. Involved in nodal signaling pathway. Acts upstream of or within several processes, including heart development; left lung morphogenesis; and spleen development. Predicted to be located in plasma membrane. Predicted to be active in cell surface and extracell ular region. Is expressed in several structures, including embryo mesoderm; intermediate mesenchyme; neural ectoderm; and primitive streak. Used to study dextro-looped transposition of the great arteries; double outlet right ventricle; right atrial isomerism; and visceral heterotaxy. Human ortholog(s) of this gene implicated in tetralogy of Fallot; visceral heterotaxy; and visceral heterotaxy 2. Orthologous to several human genes including CFC1B (cryptic, EGF-CFC family member 1B). [provided by Alliance of Genome Resources, Jul 2025] | 1 | 34574729 | 34583392 | Mouse | 111 | name , description | gene, protein-coding, VALIDATED [RefSeq] |
| 1343635 | EDIL3 | EGF like and discoidin domains 3 | The protein encoded by this gene is an integrin ligand. It plays an important role in mediating angiogenesis and may be important in vessel wall remodeling and development. It also influences endothelial cell behavior. [provided by RefSeq, Jul 2008] | 5 | 83940554 | 84384880 | Human | 93 | old_gene_name , name | gene, protein-coding, REVIEWED [RefSeq] |
| 1588887 | Edil3 | EGF like and discoidin domains 3 | ENCODES a protein that exhibits calcium ion binding (inferred); INVOLVED IN positive regulation of cell-substrate adhesion (ortholog); ASSOCIATED WITH osteoarthritis (ortholog); FOUND IN extracellular region (inferred); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofura n; amphetamine | 2 | 21625604 | 22140380 | Rat | 86 | old_gene_name , name | gene, protein-coding, VALIDATED [RefSeq] |
| 9065833 | Edil3 | EGF like and discoidin domains 3 | INVOLVED IN positive regulation of cell-substrate adhesion (ortholog); ASSOCIATED WITH osteoarthritis (ortholog) | NW_004955418 | 26391309 | 26680553 | Chinchilla | 2 | old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 11840542 | EDIL3 | EGF like and discoidin domains 3 | ENCODES a protein that exhibits calcium ion binding (inferred); signaling receptor activity (inferred); INVOLVED IN positive regulation of cell-substrate adhesion (ortholog); ASSOCIATED WITH osteoarthritis (ortholog); FOUND IN extracellular region (inferred); plasma membrane (inferred) | 5 | 30895036 | 31337176 | Bonobo | 7 | old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 18910011 | Edil3 | EGF like and discoidin domains 3 | ENCODES a protein that exhibits calcium ion binding (inferred); signaling receptor activity (inferred); INVOLVED IN positive regulation of cell-substrate adhesion (ortholog); ASSOCIATED WITH osteoarthritis (ortholog); FOUND IN extracellular region (inferred); plasma membrane (inferred) | | | | Naked Mole-Rat | 7 | old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 626112720 | Edil3 | EGF like and discoidin domains 3 | INVOLVED IN positive regulation of cell-substrate adhesion (ortholog); ASSOCIATED WITH osteoarthritis (ortholog) | | | | Black Rat | 2 | old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 2289769 | CFC1B | cryptic, EGF-CFC family member 1B | Predicted to enable activin receptor binding activity and nodal binding activity. Predicted to be involved in circulatory system development; nodal signaling pathway; and regionalization. Predicted to act upstream of or within several processes, including heart development; left lung morphogenesis; and spleen development. Predicted to be active in cell surface and extracellular region. Implicated in tetralogy of Fallot and visceral heterotaxy. [provided by Alliance of Genome Resources, Jul 2025] | 2 | 130521222 | 130528603 | Human | 61 | name | gene, protein-coding, VALIDATED [RefSeq] |
| 11869123 | CFC1B | cryptic, EGF-CFC family member 1B | ENCODES a protein that exhibits activin receptor binding (ortholog); INVOLVED IN anterior/posterior pattern specification (ortholog); atrial septum morphogenesis (ortholog); coronary vasculature development (ortholog); ASSOCIATED WITH dextro-looped transposition of the great arteries (ortholog); dou ble outlet right ventricle (ortholog); right atrial isomerism (ortholog) | 2B | 29354004 | 29362161 | Bonobo | 26 | name | gene, protein-coding, MODEL [RefSeq] |
| 14002734 | CFC1B | cryptic, EGF-CFC family member 1B | INVOLVED IN anterior/posterior pattern specification (ortholog); atrial septum morphogenesis (ortholog); coronary vasculature development (ortholog); ASSOCIATED WITH dextro-looped transposition of the great arteries (ortholog); double outlet right ventricle (ortholog); right atrial isomerism (orthol og) | | | | Pig | 33 | name | gene, protein-coding, MODEL [RefSeq] |
| 1307225 | Egfem1 | EGF-like and EMI domain containing 1 | ENCODES a protein that exhibits calcium ion binding (inferred); FOUND IN extracellular region (inferred); INTERACTS WITH 1,2-dimethylhydrazine; 6-propyl-2-thiouracil; atrazine | 2 | 115601768 | 116253029 | Rat | 8 | symbol , old_gene_name , PhenoGen , name | gene, protein-coding, VALIDATED [RefSeq] |
| 1316291 | Egfem1 | EGF-like and EMI domain containing 1 | Predicted to enable calcium ion binding activity. Orthologous to human EGFEM1P (EGF like and EMI domain containing 1, pseudogene). [provided by Alliance of Genome Resources, Jul 2025] | 3 | 29135695 | 29831923 | Mouse | 38 | symbol , old_gene_name , PhenoGen , name , description | gene, protein-coding, VALIDATED [RefSeq] |
| 14004501 | EGFEM1 | EGF like and EMI domain containing 1 | | | | | Pig | | symbol , name | gene, protein-coding, MODEL [RefSeq] |
| 1551256 | Creld1 | cysteine-rich with EGF-like domains 1 | Predicted to enable calcium ion binding activity and protein disulfide isomerase activity. Predicted to be an extracellular matrix structural constituent. Is active in glutamatergic synapse. Is expressed in branchial arch; heart; and nervous system. Human ortholog(s) of this gene implicated in atrio ventricular septal defect and heart septal defect. Orthologous to human CRELD1 (cysteine rich with EGF like domains 1). [provided by Alliance of Genome Resources, Jul 2025] | 6 | 113460317 | 113470304 | Mouse | 120 | old_gene_name , name , description | gene, protein-coding, VALIDATED [RefSeq] |
| 12202680 | CRELD1 | cysteine rich with EGF like domains 1 | ENCODES a protein that exhibits calcium ion binding (inferred); isomerase activity (inferred); protein disulfide isomerase activity (inferred); ASSOCIATED WITH Atrioventricular Septal Defect 2 (ortholog); Congenital Heart Defects, Multiple Types, 4 (ortholog); congenital heart disease (ortholog); FO UND IN glutamatergic synapse (inferred); membrane (inferred); synapse (inferred) | 20 | 8333911 | 8342429 | Dog | 19 | old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 14159461 | CRELD1 | cysteine rich with EGF like domains 1 | ENCODES a protein that exhibits calcium ion binding (inferred); isomerase activity (inferred); protein disulfide isomerase activity (inferred); ASSOCIATED WITH Atrioventricular Septal Defect 2 (ortholog); Congenital Heart Defects, Multiple Types, 4 (ortholog); congenital heart disease (ortholog); FO UND IN glutamatergic synapse (inferred); membrane (inferred); synapse (inferred); INTERACTS WITH deoxynivalenol | | | | Pig | 22 | old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 1321619 | Creld2 | cysteine-rich with EGF-like domains 2 | Predicted to enable calcium ion binding activity and protein disulfide isomerase activity. Predicted to be an extracellular matrix structural constituent. Located in Golgi apparatus; endoplasmic reticulum; and extracellular space. Is expressed in several structures, including alimentary system; brai n; genitourinary system; long bone; and respiratory system. Orthologous to human CRELD2 (cysteine rich with EGF like domains 2). [provided by Alliance of Genome Resources, Jul 2025] | 15 | 88703849 | 88710884 | Mouse | 166 | old_gene_name , name , description | gene, protein-coding, PROVISIONAL [RefSeq] |
| 12057036 | CRELD2 | cysteine rich with EGF like domains 2 | ENCODES a protein that exhibits calcium ion binding (inferred); isomerase activity (inferred); protein disulfide isomerase activity (inferred); FOUND IN endoplasmic reticulum (inferred); extracellular space (inferred); Golgi apparatus (inferred) | 10 | 17286141 | 17293327 | Dog | 10 | old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 14023286 | CRELD2 | cysteine rich with EGF like domains 2 | ENCODES a protein that exhibits calcium ion binding (inferred); isomerase activity (inferred); protein disulfide isomerase activity (inferred); FOUND IN endoplasmic reticulum (inferred); extracellular space (inferred); Golgi apparatus (inferred); INTERACTS WITH deoxynivalenol | | | | Pig | 12 | old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 1349916 | SNED1 | sushi, nidogen and EGF like domains 1 | Predicted to enable Notch binding activity. Predicted to be involved in cell-matrix adhesion. Located in extracellular matrix. [provided by Alliance of Genome Resources, Jul 2025] | 2 | 240997650 | 241095568 | Human | 88 | old_gene_name , name | gene, protein-coding, VALIDATED [RefSeq] |
| 1558447 | Sned1 | sushi, nidogen and EGF-like domains 1 | Predicted to enable Notch binding activity. Predicted to be involved in cell-matrix adhesion. Located in extracellular matrix. Is expressed in several structures, including alimentary system; central nervous system; embryo mesenchyme; limb interdigital region; and mesothelium. Orthologous to human S NED1 (sushi, nidogen and EGF like domains 1). [provided by Alliance of Genome Resources, Jul 2025] | 1 | 93163563 | 93228787 | Mouse | 91 | old_gene_name , name , description | gene, protein-coding, VALIDATED [RefSeq] |
| 1566079 | Sned1 | sushi, nidogen and EGF-like domains 1 | ENCODES a protein that exhibits calcium ion binding (inferred); INVOLVED IN cell-matrix adhesion (inferred); FOUND IN extracellular matrix (ortholog); INTERACTS WITH (+)-schisandrin B; 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine | 9 | 101221497 | 101281401 | Rat | 89 | old_gene_name , name | gene, protein-coding, VALIDATED [RefSeq] |
| 8864890 | Sned1 | sushi, nidogen and EGF like domains 1 | FOUND IN extracellular matrix (ortholog) | NW_004955542 | 587159 | 628159 | Chinchilla | 2 | old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 11707592 | SNED1 | sushi, nidogen and EGF like domains 1 | ENCODES a protein that exhibits calcium ion binding (inferred); INVOLVED IN cell-matrix adhesion (inferred); FOUND IN extracellular matrix (inferred) | 2B | 128253888 | 128351819 | Bonobo | 4 | old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 12169596 | SNED1 | sushi, nidogen and EGF like domains 1 | ENCODES a protein that exhibits calcium ion binding (inferred); INVOLVED IN cell-matrix adhesion (inferred); FOUND IN extracellular matrix (inferred) | 25 | 51057358 | 51139808 | Dog | 5 | old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 12530050 | Sned1 | sushi, nidogen and EGF like domains 1 | ENCODES a protein that exhibits calcium ion binding (inferred); INVOLVED IN cell-matrix adhesion (inferred); FOUND IN extracellular matrix (inferred) | NW_004936745 | 709446 | 761932 | Squirrel | 4 | old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 14056565 | SNED1 | sushi, nidogen and EGF like domains 1 | ENCODES a protein that exhibits calcium ion binding (inferred); INVOLVED IN cell-matrix adhesion (inferred); FOUND IN extracellular matrix (inferred); INTERACTS WITH deoxynivalenol; zearalenone | | | | Pig | 7 | old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 18402531 | SNED1 | sushi, nidogen and EGF like domains 1 | ENCODES a protein that exhibits calcium ion binding (inferred); Notch binding (inferred); INVOLVED IN cell-matrix adhesion (inferred); Notch signaling pathway (inferred); FOUND IN extracellular matrix (inferred) | | | | Green Monkey | 6 | old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 18912229 | Sned1 | sushi, nidogen and EGF like domains 1 | ENCODES a protein that exhibits calcium ion binding (inferred); Notch binding (inferred); INVOLVED IN cell-matrix adhesion (inferred); establishment or maintenance of epithelial cell apical/basal polarity (inferred); heterophilic cell-cell adhesion (inferred); FOUND IN extracellular matrix (inferred ); plasma membrane (inferred); protein-containing complex (inferred) | | | | Naked Mole-Rat | 9 | old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 625921223 | Sned1 | sushi, nidogen and EGF like domains 1 | FOUND IN extracellular matrix (ortholog) | | | | Black Rat | 2 | old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 1359385 | Dner | delta/notch-like EGF repeat containing | ENCODES a protein that exhibits Notch binding (ortholog); INVOLVED IN central nervous system development (ortholog); glial cell differentiation (ortholog); Notch receptor processing (ortholog); PARTICIPATES IN Notch signaling pathway; FOUND IN dendrite (ortholog); early endosome (ortholog); neuronal cell body (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran; 6-propyl-2-thiouracil | 9 | 93035108 | 93350568 | Rat | 158 | old_gene_name , name | gene, protein-coding, VALIDATED [RefSeq] |
| 1550695 | Dner | delta/notch-like EGF repeat containing | Enables Notch binding activity. Acts upstream of or within Notch receptor processing; glial cell differentiation; and skeletal muscle fiber development. Located in dendrite and neuronal cell body. Is expressed in several structures, including alimentary system; central nervous system; limb; peripher al nervous system ganglion; and sensory organ. Orthologous to human DNER (delta/notch like EGF repeat containing). [provided by Alliance of Genome Resources, Jul 2025] | 1 | 84347560 | 84673942 | Mouse | 171 | old_gene_name , name , description | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1605895 | DNER | delta/notch like EGF repeat containing | Predicted to enable Notch binding activity. Involved in central nervous system development. Located in dendrite; early endosome; and plasma membrane. [provided by Alliance of Genome Resources, Jul 2025] | 2 | 229357629 | 229714555 | Human | 159 | old_gene_name , name | gene, protein-coding, VALIDATED [RefSeq] |
| 8964101 | Dner | delta/notch like EGF repeat containing | ENCODES a protein that exhibits Notch binding (ortholog); INVOLVED IN central nervous system development (ortholog); glial cell differentiation (ortholog); Notch receptor processing (ortholog); PARTICIPATES IN Notch signaling pathway; FOUND IN dendrite (ortholog); early endosome (ortholog); neuronal cell body (ortholog) | NW_004955453 | 5307256 | 5615550 | Chinchilla | 14 | old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 11898051 | DNER | delta/notch like EGF repeat containing | ENCODES a protein that exhibits calcium ion binding (inferred); Notch binding (inferred); INVOLVED IN glial cell differentiation (ortholog); Notch receptor processing (ortholog); skeletal muscle fiber development (ortholog); PARTICIPATES IN Notch signaling pathway; FOUND IN dendrite (inferred); earl y endosome (inferred); neuronal cell body (inferred) | 2B | 116604193 | 116963026 | Bonobo | 18 | name | gene, protein-coding, MODEL [RefSeq] |
| 12128207 | DNER | delta/notch like EGF repeat containing | ENCODES a protein that exhibits calcium ion binding (inferred); Notch binding (inferred); INVOLVED IN glial cell differentiation (ortholog); Notch receptor processing (ortholog); skeletal muscle fiber development (ortholog); PARTICIPATES IN Notch signaling pathway; FOUND IN cell periphery (inferred) ; dendrite (inferred); early endosome (inferred) | 25 | 41709570 | 41887705 | Dog | 26 | name | gene, protein-coding, MODEL [RefSeq] |
| 12492362 | Dner | delta/notch like EGF repeat containing | ENCODES a protein that exhibits calcium ion binding (inferred); Notch binding (inferred); INVOLVED IN glial cell differentiation (ortholog); Notch receptor processing (ortholog); skeletal muscle fiber development (ortholog); PARTICIPATES IN Notch signaling pathway; FOUND IN dendrite (inferred); earl y endosome (inferred); neuronal cell body (inferred) | NW_004936525 | 6734924 | 7037947 | Squirrel | 23 | name | gene, protein-coding, MODEL [RefSeq] |
| 13849718 | DNER | delta/notch like EGF repeat containing | ENCODES a protein that exhibits calcium ion binding (inferred); Notch binding (inferred); INVOLVED IN glial cell differentiation (ortholog); Notch receptor processing (ortholog); skeletal muscle fiber development (ortholog); PARTICIPATES IN Notch signaling pathway; FOUND IN cell periphery (inferred) ; dendrite (inferred); early endosome (inferred); INTERACTS WITH deoxynivalenol | | | | Pig | 24 | name | gene, protein-coding, MODEL [RefSeq] |
| 18793710 | DNER | delta/notch like EGF repeat containing | ENCODES a protein that exhibits calcium ion binding (inferred); Notch binding (inferred); INVOLVED IN glial cell differentiation (ortholog); Notch receptor processing (ortholog); skeletal muscle fiber development (ortholog); PARTICIPATES IN Notch signaling pathway; FOUND IN dendrite (inferred); earl y endosome (inferred); neuronal cell body (inferred) | | | | Green Monkey | 18 | name | gene, protein-coding, MODEL [RefSeq] |
| 18936940 | Dner | delta/notch like EGF repeat containing | ENCODES a protein that exhibits Notch binding (ortholog); INVOLVED IN central nervous system development (ortholog); glial cell differentiation (ortholog); Notch receptor processing (ortholog); PARTICIPATES IN Notch signaling pathway; FOUND IN early endosome (ortholog); neuronal cell body (ortholog) | | | | Naked Mole-Rat | 21 | name | gene, protein-coding, MODEL [RefSeq] |
| 625851596 | Dner | delta/notch like EGF repeat containing | ENCODES a protein that exhibits Notch binding (ortholog); INVOLVED IN central nervous system development (ortholog); glial cell differentiation (ortholog); Notch receptor processing (ortholog); PARTICIPATES IN Notch signaling pathway; FOUND IN dendrite (ortholog); early endosome (ortholog); neuronal cell body (ortholog) | | | | Black Rat | 14 | name | gene, protein-coding, MODEL [RefSeq] |
| 1552258 | Hbegf | heparin-binding EGF-like growth factor | Enables epidermal growth factor receptor binding activity; heparin binding activity; and signaling receptor activator activity. Involved in several processes, including ERBB2 signaling pathway; positive regulation of keratinocyte migration; and wound healing, spreading of epidermal cells. Acts upstr eam of or within several processes, including epidermal growth factor receptor signaling pathway; positive regulation of peptidyl-tyrosine phosphorylation; and regulation of heart contraction. Located in extracellular space and plasma membrane. Is expressed in several structures, including alimentary system; branchial arch; heart; submandibular gland primordium; and telencephalon. Human ortholog(s) of this gene implicated in glomerulosclerosis and perinatal necrotizing enterocolitis. Orthologous to human HBEGF (heparin binding EGF like growth factor). [provided by Alliance of Genome Resources, Jul 2025] | 18 | 36637980 | 36648858 | Mouse | 486 | symbol , old_gene_name , PhenoGen , name , description , old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 1605733 | HBEGF | heparin binding EGF like growth factor | Enables growth factor activity; heparin binding activity; and transmembrane receptor protein tyrosine kinase activator activity. Involved in several processes, including epidermal growth factor receptor signaling pathway; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal t ransduction; and positive regulation of wound healing. Located in cell surface. Is active in extracellular space. Implicated in glomerulosclerosis and perinatal necrotizing enterocolitis. [provided by Alliance of Genome Resources, Jul 2025] | 5 | 140332843 | 140346603 | Human | 402 | symbol , old_gene_name , COSMIC , name , Human Proteome Map , old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 8975288 | Hbegf | heparin binding EGF like growth factor | ENCODES a protein that exhibits epidermal growth factor receptor binding (ortholog); growth factor activity (ortholog); heparin binding (ortholog); INVOLVED IN cell chemotaxis (ortholog); cell migration (ortholog); epidermal growth factor receptor signaling pathway (ortholog); PARTICIPATES IN epider mal growth factor/neuregulin signaling pathway; ASSOCIATED WITH acute kidney failure (ortholog); Animal Disease Models (ortholog); Cardiotoxicity (ortholog); FOUND IN cell surface (ortholog); extracellular space (ortholog); plasma membrane (ortholog) | NW_004955418 | 259860 | 321340 | Chinchilla | 58 | symbol , old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 11732924 | HBEGF | heparin binding EGF like growth factor | ENCODES a protein that exhibits epidermal growth factor receptor binding (ortholog); growth factor activity (ortholog); INVOLVED IN epidermal growth factor receptor signaling pathway (ortholog); negative regulation of glycoprotein biosynthetic process (ortholog); positive regulation of cell growth ( ortholog); PARTICIPATES IN epidermal growth factor/neuregulin signaling pathway; ASSOCIATED WITH acute kidney failure (ortholog); Animal Disease Models (ortholog); Cardiotoxicity (ortholog); FOUND IN extracellular space (ortholog) | 5 | 135699553 | 135713366 | Bonobo | 65 | symbol , old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 12242074 | HBEGF | heparin binding EGF like growth factor | ENCODES a protein that exhibits epidermal growth factor receptor binding (ortholog); growth factor activity (ortholog); INVOLVED IN epidermal growth factor receptor signaling pathway (ortholog); negative regulation of glycoprotein biosynthetic process (ortholog); positive regulation of cell growth ( ortholog); PARTICIPATES IN epidermal growth factor/neuregulin signaling pathway; ASSOCIATED WITH acute kidney failure (ortholog); Animal Disease Models (ortholog); Cardiotoxicity (ortholog); FOUND IN cell surface (inferred); extracellular region (inferred); extracellular space (inferred) | 2 | 35551248 | 35563310 | Dog | 62 | symbol , old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 12601187 | Hbegf | heparin binding EGF like growth factor | ENCODES a protein that exhibits epidermal growth factor receptor binding (ortholog); growth factor activity (ortholog); INVOLVED IN epidermal growth factor receptor signaling pathway (ortholog); negative regulation of glycoprotein biosynthetic process (ortholog); positive regulation of cell growth ( ortholog); PARTICIPATES IN epidermal growth factor/neuregulin signaling pathway; ASSOCIATED WITH acute kidney failure (ortholog); Animal Disease Models (ortholog); Cardiotoxicity (ortholog); FOUND IN extracellular space (ortholog) | NW_004936531 | 9332939 | 9345039 | Squirrel | 64 | symbol , old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 13847461 | HBEGF | heparin binding EGF like growth factor | ENCODES a protein that exhibits epidermal growth factor receptor binding (ortholog); growth factor activity (ortholog); INVOLVED IN epidermal growth factor receptor signaling pathway (ortholog); negative regulation of glycoprotein biosynthetic process (ortholog); positive regulation of cell growth ( ortholog); PARTICIPATES IN epidermal growth factor/neuregulin signaling pathway; ASSOCIATED WITH acute kidney failure (ortholog); Animal Disease Models (ortholog); Cardiotoxicity (ortholog); FOUND IN cell surface (inferred); extracellular region (inferred); extracellular space (inferred); INTERACTS WITH bis(2-chloroethyl) sulfide; molybdenum atom; resveratrol | | | | Pig | 66 | symbol , old_gene_name , name | gene, protein-coding, PROVISIONAL [RefSeq] |
| 18578278 | HBEGF | heparin binding EGF like growth factor | ENCODES a protein that exhibits epidermal growth factor receptor binding (ortholog); growth factor activity (ortholog); INVOLVED IN epidermal growth factor receptor signaling pathway (ortholog); negative regulation of glycoprotein biosynthetic process (ortholog); positive regulation of cell growth ( ortholog); PARTICIPATES IN epidermal growth factor/neuregulin signaling pathway; ASSOCIATED WITH acute kidney failure (ortholog); Animal Disease Models (ortholog); Cardiotoxicity (ortholog); FOUND IN extracellular space (ortholog) | | | | Green Monkey | 65 | symbol , old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 18932712 | Hbegf | heparin binding EGF like growth factor | ENCODES a protein that exhibits epidermal growth factor receptor binding (ortholog); growth factor activity (ortholog); transmembrane receptor protein tyrosine kinase activator activity (ortholog); INVOLVED IN cell chemotaxis (ortholog); cell migration (ortholog); epidermal growth factor receptor si gnaling pathway (ortholog); PARTICIPATES IN epidermal growth factor/neuregulin signaling pathway; ASSOCIATED WITH acute kidney failure (ortholog); Animal Disease Models (ortholog); Cardiotoxicity (ortholog); FOUND IN cell surface (ortholog); extracellular space (ortholog) | | | | Naked Mole-Rat | 57 | symbol , old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 625874833 | Hbegf | heparin binding EGF like growth factor | ENCODES a protein that exhibits epidermal growth factor receptor binding (ortholog); growth factor activity (ortholog); heparin binding (ortholog); INVOLVED IN cell chemotaxis (ortholog); cell migration (ortholog); epidermal growth factor receptor signaling pathway (ortholog); PARTICIPATES IN epider mal growth factor/neuregulin signaling pathway; ASSOCIATED WITH acute kidney failure (ortholog); Animal Disease Models (ortholog); Cardiotoxicity (ortholog); FOUND IN cell surface (ortholog); extracellular space (ortholog); plasma membrane (ortholog) | | | | Black Rat | 58 | symbol , old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 1319122 | Scube1 | signal peptide, CUB domain, EGF-like 1 | Predicted to enable identical protein binding activity. Acts upstream of or within positive regulation of smoothened signaling pathway. Predicted to be located in external side of plasma membrane. Predicted to be active in cell surface and extracellular space. Is expressed in several structures, inc luding allantois; embryo ectoderm; embryo mesenchyme; forelimb bud; and genitourinary system. Orthologous to human SCUBE1 (signal peptide, CUB domain and EGF like domain containing 1). [provided by Alliance of Genome Resources, Jul 2025] | 15 | 83486784 | 83609252 | Mouse | 111 | old_gene_name , name , description | gene, protein-coding, VALIDATED [RefSeq] |
| 1617561 | Scube2 | signal peptide, CUB domain, EGF-like 2 | Enables hedgehog family protein binding activity. Acts upstream of or within several processes, including chondrocyte differentiation involved in endochondral bone morphogenesis; positive regulation of chondrocyte proliferation; and positive regulation of osteoblast differentiation. Located in extra cellular space. Is expressed in several structures, including cardiovascular system; central nervous system; neural ectoderm; sensory organ; and skeleton. Orthologous to human SCUBE2 (signal peptide, CUB domain and EGF like domain containing 2). [provided by Alliance of Genome Resources, Jul 2025] | 7 | 109397897 | 109464886 | Mouse | 115 | old_gene_name , name , description , old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 1614840 | Scube3 | signal peptide, CUB domain, EGF-like 3 | Predicted to enable BMP binding activity; BMP receptor binding activity; and identical protein binding activity. Involved in positive regulation of osteoblast differentiation. Acts upstream of or within positive regulation of smoothened signaling pathway. Predicted to be located in plasma membrane. Predicted to be active in cell surface and extracellular space. Is expressed in several structures, including embryo ectoderm; embryo mesenchyme; integumental system; jaw; and sensory organ. Human ortholog(s) of this gene implicated in short stature, facial dysmorphism, and skeletal anomalies with or without cardiac anomalies 2. Orthologous to human SCUBE3 (signal peptide, CUB domain and EGF like domain containing 3). [provided by Alliance of Genome Resources, Jul 2025] | 17 | 28361074 | 28393825 | Mouse | 165 | old_gene_name , name , description , old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 1309910 | Vwce | von Willebrand factor C and EGF domains | ENCODES a protein that exhibits calcium ion binding (inferred); INVOLVED IN cellular response to virus (inferred); ASSOCIATED WITH Dwarfism (ortholog); FOUND IN cytoplasm (ortholog); cytosol (ortholog); nucleoplasm (ortholog); INTERACTS WITH (+)-schisandrin B; 2,3,7,8-tetrachlorodibenzodioxine; 2,4- dinitrotoluene | 1 | 216703742 | 216753284 | Rat | 94 | old_gene_name , name | gene, protein-coding, VALIDATED [RefSeq] |
| 1332003 | Vwce | von Willebrand factor C and EGF domains | Predicted to enable calcium ion binding activity. Predicted to be involved in cellular response to virus. Predicted to be located in extracellular region. Predicted to be active in cytoplasm. Is expressed in left lung; mandible; maxilla; orbito-sphenoid; and right lung. Orthologous to human VWCE (vo n Willebrand factor C and EGF domains). [provided by Alliance of Genome Resources, Jul 2025] | 19 | 10611582 | 10643577 | Mouse | 96 | old_gene_name , name , description | gene, protein-coding, VALIDATED [RefSeq] |
| 1602968 | VWCE | von Willebrand factor C and EGF domains | Predicted to enable calcium ion binding activity. Predicted to be involved in cellular response to virus. Located in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025] | 11 | 61258286 | 61295316 | Human | 92 | old_gene_name , name | gene, protein-coding, VALIDATED [RefSeq] |
| 9062428 | Vwce | von Willebrand factor C and EGF domains | ASSOCIATED WITH Dwarfism (ortholog); FOUND IN cytoplasm (ortholog); cytosol (ortholog); nucleoplasm (ortholog) | NW_004955511 | 6235934 | 6251186 | Chinchilla | 6 | name | gene, protein-coding, MODEL [RefSeq] |
| 12023740 | VWCE | von Willebrand factor C and EGF domains | ENCODES a protein that exhibits calcium ion binding (inferred); INVOLVED IN cellular response to virus (inferred); ASSOCIATED WITH Dwarfism (ortholog); FOUND IN cytoplasm (inferred); cytosol (inferred); extracellular region (inferred) | 11 | 56557167 | 56596311 | Bonobo | 11 | name | gene, protein-coding, MODEL [RefSeq] |
| 12290319 | VWCE | von Willebrand factor C and EGF domains | ENCODES a protein that exhibits calcium ion binding (inferred); INVOLVED IN cellular response to virus (inferred); ASSOCIATED WITH Dwarfism (ortholog); FOUND IN cytoplasm (inferred); cytosol (inferred); extracellular region (inferred) | 18 | 55099193 | 55125412 | Dog | 11 | old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 12495713 | Vwce | von Willebrand factor C and EGF domains | ASSOCIATED WITH Dwarfism (ortholog); FOUND IN cytoplasm (ortholog); cytosol (ortholog); nucleoplasm (ortholog) | NW_004936581 | 1748511 | 1770648 | Squirrel | 6 | name | gene, protein-coding, MODEL [RefSeq] |
| 14050202 | VWCE | von Willebrand factor C and EGF domains | ENCODES a protein that exhibits calcium ion binding (inferred); INVOLVED IN cellular response to virus (inferred); ASSOCIATED WITH Dwarfism (ortholog); FOUND IN cytoplasm (inferred); cytosol (inferred); extracellular region (inferred) | | | | Pig | 11 | old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 18755085 | VWCE | von Willebrand factor C and EGF domains | ENCODES a protein that exhibits calcium ion binding (inferred); INVOLVED IN cellular response to virus (inferred); ASSOCIATED WITH Dwarfism (ortholog); FOUND IN cytoplasm (inferred); cytosol (inferred); extracellular region (inferred) | | | | Green Monkey | 11 | old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 18928571 | Vwce | von Willebrand factor C and EGF domains | ENCODES a protein that exhibits calcium ion binding (inferred); INVOLVED IN cellular response to virus (inferred); ASSOCIATED WITH Dwarfism (ortholog); FOUND IN cytosol (ortholog); nucleoplasm (ortholog) | | | | Naked Mole-Rat | 9 | old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 626055748 | Vwce | von Willebrand factor C and EGF domains | ASSOCIATED WITH Dwarfism (ortholog); FOUND IN cytoplasm (ortholog); cytosol (ortholog); nucleoplasm (ortholog) | | | | Black Rat | 6 | old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 1561223 | Vwde | von Willebrand factor D and EGF domains | ENCODES a protein that exhibits calcium ion binding (inferred); ASSOCIATED WITH optic atrophy 12 (ortholog); INTERACTS WITH bisphenol A; indole-3-methanol; 2,3,7,8-tetrachlorodibenzodioxine (ortholog) | 4 | 42419676 | 42468992 | Rat | 39 | old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 1614921 | Vwde | von Willebrand factor D and EGF domains | Predicted to be located in extracellular region. Is expressed in tooth. Orthologous to human VWDE (von Willebrand factor D and EGF domains). [provided by Alliance of Genome Resources, Jul 2025] | 6 | 13156439 | 13224964 | Mouse | 42 | old_gene_name , name , description | gene, protein-coding, VALIDATED [RefSeq] |
| 2299987 | VWDE | von Willebrand factor D and EGF domains | Predicted to enable signaling receptor binding activity. Predicted to be active in cell surface and extracellular region. [provided by Alliance of Genome Resources, Jul 2025] | 7 | 12330885 | 12403865 | Human | 40 | old_gene_name , name | gene, protein-coding, VALIDATED [RefSeq] |
| 8749502 | Vwde | von Willebrand factor D and EGF domains | ASSOCIATED WITH optic atrophy 12 (ortholog) | NW_004955432 | 18687192 | 18752679 | Chinchilla | 1 | name | gene, protein-coding, MODEL [RefSeq] |
| 11977960 | VWDE | von Willebrand factor D and EGF domains | ASSOCIATED WITH optic atrophy 12 (ortholog) | 7 | 13028161 | 13106766 | Bonobo | 1 | old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 12249177 | VWDE | von Willebrand factor D and EGF domains | ENCODES a protein that exhibits calcium ion binding (inferred); ASSOCIATED WITH optic atrophy 12 (ortholog) | 14 | 27183263 | 27280746 | Dog | 5 | old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 12571416 | Vwde | von Willebrand factor D and EGF domains | ASSOCIATED WITH optic atrophy 12 (ortholog) | NW_004936761 | 1749471 | 1818294 | Squirrel | 1 | name | gene, protein-coding, MODEL [RefSeq] |
| 13883407 | VWDE | von Willebrand factor D and EGF domains | ENCODES a protein that exhibits calcium ion binding (inferred); ASSOCIATED WITH optic atrophy 12 (ortholog); INTERACTS WITH deoxynivalenol | | | | Pig | 6 | old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 18704208 | VWDE | von Willebrand factor D and EGF domains | ENCODES a protein that exhibits signaling receptor binding (inferred); ASSOCIATED WITH optic atrophy 12 (ortholog); FOUND IN cell surface (inferred); extracellular region (inferred) | | | | Green Monkey | 4 | old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 18936709 | Vwde | von Willebrand factor D and EGF domains | ENCODES a protein that exhibits signaling receptor binding (inferred); ASSOCIATED WITH optic atrophy 12 (ortholog); FOUND IN cell surface (inferred); extracellular region (inferred) | | | | Naked Mole-Rat | 4 | old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 626008757 | Vwde | von Willebrand factor D and EGF domains | ASSOCIATED WITH optic atrophy 12 (ortholog) | | | | Black Rat | 1 | old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 12103086 | EDIL3 | EGF like repeats and discoidin domains 3 | ENCODES a protein that exhibits calcium ion binding (inferred); INVOLVED IN positive regulation of cell-substrate adhesion (ortholog); ASSOCIATED WITH osteoarthritis (ortholog); FOUND IN extracellular region (inferred) | 3 | 23417889 | 23811270 | Dog | 7 | old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 12568973 | Edil3 | EGF like repeats and discoidin domains 3 | ENCODES a protein that exhibits calcium ion binding (inferred); signaling receptor activity (inferred); INVOLVED IN positive regulation of cell-substrate adhesion (ortholog); ASSOCIATED WITH osteoarthritis (ortholog); FOUND IN extracellular region (inferred); plasma membrane (inferred) | NW_004936469 | 2998424 | 3391386 | Squirrel | 7 | old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 14035821 | EDIL3 | EGF like repeats and discoidin domains 3 | ENCODES a protein that exhibits calcium ion binding (inferred); INVOLVED IN positive regulation of cell-substrate adhesion (ortholog); ASSOCIATED WITH osteoarthritis (ortholog); FOUND IN extracellular region (inferred) | | | | Pig | 7 | old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 18429562 | EDIL3 | EGF like repeats and discoidin domains 3 | ENCODES a protein that exhibits calcium ion binding (inferred); signaling receptor activity (inferred); INVOLVED IN positive regulation of cell-substrate adhesion (ortholog); ASSOCIATED WITH osteoarthritis (ortholog); FOUND IN extracellular region (inferred); plasma membrane (inferred) | | | | Green Monkey | 7 | old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 40999476 | Egfl7-ps1 | EGF-like-domain, multiple 7, pseudogene 1 | | 18 | 69590200 | 69593256 | Rat | | symbol , PhenoGen , name | gene, pseudo, MODEL [RefSeq] |
| 1343004 | EYS | EGF-like photoreceptor maintenance factor | The product of this gene contains multiple epidermal growth factor (EGF)-like and LamG domains. The protein is expressed in the photoreceptor layer of the retina, and the gene is mutated in autosomal recessive retinitis pigmentosa. Multiple transcript variants e ncoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2008] | 6 | 63719980 | 65707226 | Human | 1253 | old_gene_name , name , description , old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 12414592 | EYS | EGF-like photoreceptor maintenance factor | INVOLVED IN detection of light stimulus involved in visual perception (ortholog); skeletal muscle tissue regeneration (ortholog); PARTICIPATES IN retinitis pigmentosa pathway; ASSOCIATED WITH choroidal sclerosis (ortholog); cone-rod dystrophy (ortholog); Eye Abnormalities (ortholog); FOUND IN centri ole (ortholog) | 12 | 27184500 | 28708705 | Dog | 17 | old_gene_name , name , old_gene_symbol | gene, protein-coding, MODEL [RefSeq] |
| 13850510 | EYS | EGF-like photoreceptor maintenance factor | INVOLVED IN detection of light stimulus involved in visual perception (ortholog); skeletal muscle tissue regeneration (ortholog); PARTICIPATES IN retinitis pigmentosa pathway; ASSOCIATED WITH choroidal sclerosis (ortholog); cone-rod dystrophy (ortholog); Eye Abnormalities (ortholog); FOUND IN centri ole (ortholog) | | | | Pig | 17 | name | gene, protein-coding, MODEL [RefSeq] |
| 1307670 | Ccbe1 | collagen and calcium binding EGF domains 1 | ENCODES a protein that exhibits collagen binding (ortholog); protease binding (ortholog); INVOLVED IN lung development (ortholog); lymph vessel development (ortholog); lymphangiogenesis (ortholog); ASSOCIATED WITH Distal Renal Tubular Acidosis 4 with Hemolytic Anemia (ortholog); Facies (ortholog); g enetic disease (ortholog); FOUND IN extracellular matrix (ortholog); extracellular space (ortholog); INTERACTS WITH bisphenol A; gentamycin; paracetamol | 18 | 61849821 | 62093876 | Rat | 123 | old_gene_name , name | gene, protein-coding, VALIDATED [RefSeq] |
| 1349047 | CCBE1 | collagen and calcium binding EGF domains 1 | This gene is thought to function in extracellular matrix remodeling and migration. It is predominantly expressed in the ovary, but down regulated in ovarian cancer cell lines and primary carcinomas, suggesting its role as a tumour suppressor. Mutations in this gene have been associated with Hennekam lymphangiectasia-lymphedema syndrome, a generalized lymphatic dysplasia in humans. [provided by RefSeq, Mar 2010] | 18 | 59430939 | 59697721 | Human | 242 | old_gene_name , name | gene, protein-coding, REVIEWED [RefSeq] |
| 1551471 | Ccbe1 | collagen and calcium binding EGF domains 1 | Predicted to enable collagen binding activity and protease binding activity. Involved in positive regulation of angiogenesis and positive regulation of lymphangiogenesis. Acts upstream of or within several processes, including lymphangiogenesis; positive regulation of endothelial cell migration; and respiratory system process. Predicted to be located in extracellular matrix and extracellular space. Predicted to be part of collagen trimer. Is expressed in several structures, including anterior cardinal vein; branchial arch; embryo mesenchyme; heart; and intraembryonic coelom. Human ortholog(s) of this gene implicated in Hennekam syndrome. Orthologous to human CCBE1 (collagen and calcium binding EGF domains 1). [provided by Alliance of Genome Resources, Jul 2025] | 18 | 66189926 | 66424909 | Mouse | 163 | old_gene_name , name , description | gene, protein-coding, VALIDATED [RefSeq] |
| 8848247 | Ccbe1 | collagen and calcium binding EGF domains 1 | ENCODES a protein that exhibits collagen binding (ortholog); protease binding (ortholog); INVOLVED IN lung development (ortholog); lymph vessel development (ortholog); lymphangiogenesis (ortholog); ASSOCIATED WITH Distal Renal Tubular Acidosis 4 with Hemolytic Anemia (ortholog); Facies (ortholog); g enetic disease (ortholog); FOUND IN extracellular matrix (ortholog); extracellular space (ortholog) | NW_004955402 | 43551810 | 43819731 | Chinchilla | 28 | old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 11698710 | CCBE1 | collagen and calcium binding EGF domains 1 | ENCODES a protein that exhibits calcium ion binding (inferred); collagen binding (inferred); protease binding (inferred); INVOLVED IN lung development (ortholog); lymph vessel development (ortholog); lymphangiogenesis (ortholog); ASSOCIATED WITH Distal Renal Tubular Acidosis 4 with Hemolytic Anemia (ortholog); Facies (ortholog); genetic disease (ortholog); FOUND IN extracellular matrix (inferred); extracellular space (inferred) | 18 | 52819591 | 53087772 | Bonobo | 29 | old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 12383915 | CCBE1 | collagen and calcium binding EGF domains 1 | ENCODES a protein that exhibits calcium ion binding (inferred); collagen binding (inferred); protease binding (inferred); INVOLVED IN lung development (ortholog); lymph vessel development (ortholog); lymphangiogenesis (ortholog); ASSOCIATED WITH Distal Renal Tubular Acidosis 4 with Hemolytic Anemia (ortholog); Facies (ortholog); genetic disease (ortholog); FOUND IN extracellular matrix (inferred); extracellular space (inferred) | 1 | 16597389 | 16819888 | Dog | 33 | old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 12706962 | Ccbe1 | collagen and calcium binding EGF domains 1 | ENCODES a protein that exhibits calcium ion binding (inferred); collagen binding (inferred); protease binding (inferred); INVOLVED IN lung development (ortholog); lymph vessel development (ortholog); lymphangiogenesis (ortholog); ASSOCIATED WITH Distal Renal Tubular Acidosis 4 with Hemolytic Anemia (ortholog); Facies (ortholog); genetic disease (ortholog); FOUND IN extracellular matrix (inferred); extracellular space (inferred) | NW_004936497 | 5290068 | 5321656 | Squirrel | 29 | old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 14026802 | CCBE1 | collagen and calcium binding EGF domains 1 | ENCODES a protein that exhibits calcium ion binding (inferred); collagen binding (inferred); protease binding (inferred); INVOLVED IN lung development (ortholog); lymph vessel development (ortholog); lymphangiogenesis (ortholog); ASSOCIATED WITH Distal Renal Tubular Acidosis 4 with Hemolytic Anemia (ortholog); Facies (ortholog); genetic disease (ortholog); FOUND IN extracellular matrix (inferred); extracellular space (inferred) | | | | Pig | 32 | old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 18689860 | CCBE1 | collagen and calcium binding EGF domains 1 | ENCODES a protein that exhibits calcium ion binding (inferred); collagen binding (inferred); protease binding (inferred); INVOLVED IN lung development (ortholog); lymph vessel development (ortholog); lymphangiogenesis (ortholog); ASSOCIATED WITH Distal Renal Tubular Acidosis 4 with Hemolytic Anemia (ortholog); Facies (ortholog); genetic disease (ortholog); FOUND IN extracellular matrix (inferred); extracellular space (inferred) | | | | Green Monkey | 29 | old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 18908962 | Ccbe1 | collagen and calcium binding EGF domains 1 | ENCODES a protein that exhibits collagen binding (ortholog); protease binding (ortholog); INVOLVED IN lung development (ortholog); lymph vessel development (ortholog); lymphangiogenesis (ortholog); ASSOCIATED WITH Distal Renal Tubular Acidosis 4 with Hemolytic Anemia (ortholog); Facies (ortholog); g enetic disease (ortholog); FOUND IN extracellular matrix (ortholog); extracellular space (ortholog) | | | | Naked Mole-Rat | 29 | old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 626091826 | Ccbe1 | collagen and calcium binding EGF domains 1 | ENCODES a protein that exhibits collagen binding (ortholog); protease binding (ortholog); INVOLVED IN lung development (ortholog); lymph vessel development (ortholog); lymphangiogenesis (ortholog); ASSOCIATED WITH Distal Renal Tubular Acidosis 4 with Hemolytic Anemia (ortholog); Facies (ortholog); g enetic disease (ortholog); FOUND IN extracellular matrix (ortholog); extracellular space (ortholog) | | | | Black Rat | 28 | old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 18908808 | LOC101724814 | EGF-like and EMI domain-containing protein 1 | ENCODES a protein that exhibits calcium ion binding (inferred) | | | | Naked Mole-Rat | 1 | name | gene, protein-coding, MODEL [RefSeq] |
| 12477734 | LOC101973364 | EGF-like and EMI domain-containing protein 1 | | NW_004936593 | 3437911 | 3667874 | Squirrel | | name | gene, protein-coding, MODEL [RefSeq] |
| 8851182 | LOC102028246 | EGF-like and EMI domain-containing protein 1 | | NW_004955448 | 17881646 | 17965623 | Chinchilla | | name | gene, protein-coding, MODEL [RefSeq] |
| 18791356 | LOC103221287 | EGF-like and EMI domain-containing protein 1 | | | | | Green Monkey | | name | gene, protein-coding, MODEL [RefSeq] |
| 626078121 | LOC116896971 | EGF-like and EMI domain-containing protein 1 | | | | | Black Rat | | name | gene, protein-coding, MODEL [RefSeq] |
| 1354258 | CELSR1 | cadherin EGF LAG seven-pass G-type receptor 1 | The protein encoded by this gene is a member of the flamingo subfamily, part of the cadherin superfamily. The flamingo subfamily consists of nonclassic-type cadherins; a subpopulation that does not interact with catenins. The flamingo cadherins are located at the plasma membrane and have nine cadher in domains, seven epidermal growth factor-like repeats and two laminin A G-type repeats in their ectodomain. They also have seven transmembrane domains, a characteristic unique to this subfamily. It is postulated that these proteins are receptors involved in contact-mediated communication, with cadherin domains acting as homophilic binding regions and the EGF-like domains involved in cell adhesion and receptor-ligand interactions. This particular member is a developmentally regulated, neural-specific gene which plays an unspecified role in early embryogenesis. [provided by RefSeq, Jul 2008] | 22 | 46361174 | 46537620 | Human | 190 | old_gene_name , name , description | gene, protein-coding, REVIEWED [RefSeq] |
| 9052746 | Celsr1 | cadherin EGF LAG seven-pass G-type receptor 1 | INVOLVED IN anterior/posterior pattern specification (ortholog); apical protein localization (ortholog); establishment of body hair planar orientation (ortholog); PARTICIPATES IN Wnt signaling, the planar cell polarity pathway; ASSOCIATED WITH bladder exstrophy-epispadias-cloacal exstrophy complex ( ortholog); long QT syndrome (ortholog); Lymphatic Malformation 9 (ortholog); FOUND IN membrane (ortholog); plasma membrane (ortholog) | NW_004955413 | 30455194 | 30561124 | Chinchilla | 33 | old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 11940008 | CELSR1 | cadherin EGF LAG seven-pass G-type receptor 1 | ENCODES a protein that exhibits calcium ion binding (inferred); G protein-coupled receptor activity (inferred); transmembrane signaling receptor activity (inferred); INVOLVED IN anterior/posterior pattern specification (ortholog); apical protein localization (ortholog); establishment of body hair pl anar orientation (ortholog); PARTICIPATES IN Wnt signaling, the planar cell polarity pathway; ASSOCIATED WITH bladder exstrophy-epispadias-cloacal exstrophy complex (ortholog); long QT syndrome (ortholog); Lymphatic Malformation 9 (ortholog); FOUND IN membrane (inferred); plasma membrane (inferred) | | | | Bonobo | 50 | old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 12361160 | CELSR1 | cadherin EGF LAG seven-pass G-type receptor 1 | ENCODES a protein that exhibits calcium ion binding (inferred); G protein-coupled receptor activity (inferred); transmembrane signaling receptor activity (inferred); INVOLVED IN anterior/posterior pattern specification (ortholog); apical protein localization (ortholog); establishment of body hair pl anar orientation (ortholog); PARTICIPATES IN Wnt signaling, the planar cell polarity pathway; ASSOCIATED WITH bladder exstrophy-epispadias-cloacal exstrophy complex (ortholog); long QT syndrome (ortholog); Lymphatic Malformation 9 (ortholog); FOUND IN membrane (inferred); plasma membrane (inferred) | 10 | 19704104 | 19836886 | Dog | 53 | old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 12475657 | Celsr1 | cadherin EGF LAG seven-pass G-type receptor 1 | ENCODES a protein that exhibits calcium ion binding (inferred); G protein-coupled receptor activity (inferred); transmembrane signaling receptor activity (inferred); INVOLVED IN anterior/posterior pattern specification (ortholog); apical protein localization (ortholog); establishment of body hair pl anar orientation (ortholog); PARTICIPATES IN Wnt signaling, the planar cell polarity pathway; ASSOCIATED WITH bladder exstrophy-epispadias-cloacal exstrophy complex (ortholog); long QT syndrome (ortholog); Lymphatic Malformation 9 (ortholog); FOUND IN membrane (inferred); plasma membrane (inferred) | NW_004936629 | 3453384 | 3570250 | Squirrel | 50 | name | gene, protein-coding, MODEL [RefSeq] |
| 18589088 | CELSR1 | cadherin EGF LAG seven-pass G-type receptor 1 | ENCODES a protein that exhibits calcium ion binding (inferred); G protein-coupled receptor activity (inferred); transmembrane signaling receptor activity (inferred); INVOLVED IN anterior/posterior pattern specification (ortholog); apical protein localization (ortholog); establishment of body hair pl anar orientation (ortholog); PARTICIPATES IN Wnt signaling, the planar cell polarity pathway; ASSOCIATED WITH bladder exstrophy-epispadias-cloacal exstrophy complex (ortholog); long QT syndrome (ortholog); Lymphatic Malformation 9 (ortholog); FOUND IN membrane (inferred); plasma membrane (inferred) | | | | Green Monkey | 50 | name | gene, protein-coding, MODEL [RefSeq] |
| 18922735 | Celsr1 | cadherin EGF LAG seven-pass G-type receptor 1 | ENCODES a protein that exhibits calcium ion binding (inferred); G protein-coupled receptor activity (inferred); transmembrane signaling receptor activity (inferred); INVOLVED IN anterior/posterior pattern specification (ortholog); apical protein localization (ortholog); establishment of body hair pl anar orientation (ortholog); PARTICIPATES IN Wnt signaling, the planar cell polarity pathway; ASSOCIATED WITH bladder exstrophy-epispadias-cloacal exstrophy complex (ortholog); long QT syndrome (ortholog); Lymphatic Malformation 9 (ortholog); FOUND IN membrane (inferred); plasma membrane (inferred) | | | | Naked Mole-Rat | 48 | name | gene, protein-coding, MODEL [RefSeq] |
| 626113261 | Celsr1 | cadherin EGF LAG seven-pass G-type receptor 1 | INVOLVED IN anterior/posterior pattern specification (ortholog); apical protein localization (ortholog); establishment of body hair planar orientation (ortholog); PARTICIPATES IN Wnt signaling, the planar cell polarity pathway; ASSOCIATED WITH bladder exstrophy-epispadias-cloacal exstrophy complex ( ortholog); long QT syndrome (ortholog); Lymphatic Malformation 9 (ortholog); FOUND IN membrane (ortholog); plasma membrane (ortholog) | | | | Black Rat | 33 | name | gene, protein-coding, MODEL [RefSeq] |
| 733345 | CELSR2 | cadherin EGF LAG seven-pass G-type receptor 2 | The protein encoded by this gene is a member of the flamingo subfamily, part of the cadherin superfamily. The flamingo subfamily consists of nonclassic-type cadherins; a subpopulation that does not interact with catenins. The flamingo cadherins are located at the plasma membrane and have nine cadher in domains, seven epidermal growth factor-like repeats and two laminin A G-type repeats in their ectodomain. They also have seven transmembrane domains, a characteristic unique to this subfamily. It is postulated that these proteins are receptors involved in contact-mediated communication, with cadherin domains acting as homophilic binding regions and the EGF-like domains involved in cell adhesion and receptor-ligand interactions. The specific function of this particular member has not been determined. [provided by RefSeq, Jul 2008] | 1 | 109249539 | 109275751 | Human | 162 | old_gene_name , name , description , old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 8882319 | Celsr2 | cadherin EGF LAG seven-pass G-type receptor 2 | INVOLVED IN cerebrospinal fluid secretion (ortholog); cilium assembly (ortholog); cilium movement (ortholog); ASSOCIATED WITH coronary artery disease (ortholog); Developmental Disabilities (ortholog); endometrial hyperplasia (ortholog); FOUND IN cytoplasm (ortholog); plasma membrane (ortholog) | NW_004955435 | 12671759 | 12695070 | Chinchilla | 25 | old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 12007085 | CELSR2 | cadherin EGF LAG seven-pass G-type receptor 2 | ENCODES a protein that exhibits calcium ion binding (inferred); G protein-coupled receptor activity (inferred); transmembrane signaling receptor activity (inferred); INVOLVED IN cerebrospinal fluid secretion (ortholog); cilium assembly (ortholog); cilium movement (ortholog); ASSOCIATED WITH coronary artery disease (ortholog); Developmental Disabilities (ortholog); endometrial hyperplasia (ortholog); FOUND IN cytoplasm (inferred); membrane (inferred); plasma membrane (inferred) | 1 | 111627551 | 111653775 | Bonobo | 46 | old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 12371426 | CELSR2 | cadherin EGF LAG seven-pass G-type receptor 2 | ENCODES a protein that exhibits calcium ion binding (inferred); G protein-coupled receptor activity (inferred); transmembrane signaling receptor activity (inferred); INVOLVED IN cerebrospinal fluid secretion (ortholog); cilium assembly (ortholog); cilium movement (ortholog); ASSOCIATED WITH coronary artery disease (ortholog); Developmental Disabilities (ortholog); endometrial hyperplasia (ortholog); FOUND IN cytoplasm (inferred); membrane (inferred); plasma membrane (inferred) | 6 | 42547638 | 42573407 | Dog | 49 | old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 12451406 | Celsr2 | cadherin EGF LAG seven-pass G-type receptor 2 | ENCODES a protein that exhibits calcium ion binding (inferred); G protein-coupled receptor activity (inferred); transmembrane signaling receptor activity (inferred); INVOLVED IN cerebrospinal fluid secretion (ortholog); cilium assembly (ortholog); cilium movement (ortholog); ASSOCIATED WITH coronary artery disease (ortholog); Developmental Disabilities (ortholog); endometrial hyperplasia (ortholog); FOUND IN cytoplasm (inferred); membrane (inferred); plasma membrane (inferred) | NW_004936704 | 779528 | 803860 | Squirrel | 46 | name | gene, protein-coding, MODEL [RefSeq] |
| 14087684 | CELSR2 | cadherin EGF LAG seven-pass G-type receptor 2 | ENCODES a protein that exhibits calcium ion binding (inferred); G protein-coupled receptor activity (inferred); transmembrane signaling receptor activity (inferred); INVOLVED IN cerebrospinal fluid secretion (ortholog); cilium assembly (ortholog); cilium movement (ortholog); ASSOCIATED WITH coronary artery disease (ortholog); Developmental Disabilities (ortholog); endometrial hyperplasia (ortholog); FOUND IN cytoplasm (inferred); membrane (inferred); plasma membrane (inferred); INTERACTS WITH deoxynivalenol | | | | Pig | 50 | name | gene, protein-coding, MODEL [RefSeq] |
| 18339538 | CELSR2 | cadherin EGF LAG seven-pass G-type receptor 2 | ENCODES a protein that exhibits calcium ion binding (inferred); G protein-coupled receptor activity (inferred); transmembrane signaling receptor activity (inferred); INVOLVED IN cerebrospinal fluid secretion (ortholog); cilium assembly (ortholog); cilium movement (ortholog); ASSOCIATED WITH coronary artery disease (ortholog); Developmental Disabilities (ortholog); endometrial hyperplasia (ortholog); FOUND IN cytoplasm (inferred); membrane (inferred); plasma membrane (inferred) | | | | Green Monkey | 46 | name | gene, protein-coding, MODEL [RefSeq] |
| 18911872 | Celsr2 | cadherin EGF LAG seven-pass G-type receptor 2 | ENCODES a protein that exhibits calcium ion binding (inferred); G protein-coupled receptor activity (inferred); transmembrane signaling receptor activity (inferred); INVOLVED IN cerebrospinal fluid secretion (ortholog); cilium assembly (ortholog); cilium movement (ortholog); ASSOCIATED WITH coronary artery disease (ortholog); Developmental Disabilities (ortholog); endometrial hyperplasia (ortholog); FOUND IN cytoplasm (ortholog) | | | | Naked Mole-Rat | 44 | name | gene, protein-coding, MODEL [RefSeq] |
| 625848791 | Celsr2 | cadherin EGF LAG seven-pass G-type receptor 2 | INVOLVED IN cerebrospinal fluid secretion (ortholog); cilium assembly (ortholog); cilium movement (ortholog); ASSOCIATED WITH coronary artery disease (ortholog); Developmental Disabilities (ortholog); endometrial hyperplasia (ortholog); FOUND IN cytoplasm (ortholog); plasma membrane (ortholog) | | | | Black Rat | 25 | name | gene, protein-coding, MODEL [RefSeq] |
| 1342685 | CELSR3 | cadherin EGF LAG seven-pass G-type receptor 3 | This gene belongs to the flamingo subfamily, which is included in the cadherin superfamily. The flamingo cadherins consist of nonclassic-type cadherins that do not interact with catenins. They are plasma membrane proteins containing seven epidermal growth factor-like repeats, nine cadherin domains a nd two laminin A G-type repeats in their ectodomain. They also have seven transmembrane domains, a characteristic feature of their subfamily. The encoded protein may be involved in the regulation of contact-dependent neurite growth and may play a role in tumor formation. [provided by RefSeq, Jun 2013] | 3 | 48636463 | 48662886 | Human | 131 | old_gene_name , name , old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 8778106 | Celsr3 | cadherin EGF LAG seven-pass G-type receptor 3 | INVOLVED IN axonal fasciculation (ortholog); cilium assembly (ortholog); dopaminergic neuron axon guidance (ortholog); ASSOCIATED WITH autism spectrum disorder (ortholog); bladder exstrophy-epispadias-cloacal exstrophy complex (ortholog); CAKUT1 (ortholog); FOUND IN glutamatergic synapse (ortholog); postsynaptic density membrane (ortholog); presynaptic active zone membrane (ortholog) | NW_004955532 | 724306 | 749192 | Chinchilla | 18 | old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 11997142 | CELSR3 | cadherin EGF LAG seven-pass G-type receptor 3 | ENCODES a protein that exhibits calcium ion binding (inferred); G protein-coupled receptor activity (inferred); transmembrane signaling receptor activity (inferred); INVOLVED IN axonal fasciculation (ortholog); cilium assembly (ortholog); dopaminergic neuron axon guidance (ortholog); ASSOCIATED WITH autism spectrum disorder (ortholog); bladder exstrophy-epispadias-cloacal exstrophy complex (ortholog); CAKUT1 (ortholog); FOUND IN glutamatergic synapse (ortholog); postsynaptic density membrane (ortholog); presynaptic active zone membrane (ortholog) | 3 | 48557976 | 48586051 | Bonobo | 35 | old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 12335776 | CELSR3 | cadherin EGF LAG seven-pass G-type receptor 3 | ENCODES a protein that exhibits bicarbonate transmembrane transporter activity (inferred); calcium ion binding (inferred); chloride transmembrane transporter activity (inferred); INVOLVED IN axonal fasciculation (ortholog); cilium assembly (ortholog); dopaminergic neuron axon guidance (ortholog); AS SOCIATED WITH autism spectrum disorder (ortholog); bladder exstrophy-epispadias-cloacal exstrophy complex (ortholog); CAKUT1 (ortholog); FOUND IN glutamatergic synapse (ortholog); postsynaptic density membrane (ortholog); presynaptic active zone membrane (ortholog) | 20 | 40457430 | 40495128 | Dog | 81 | old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 12474169 | Celsr3 | cadherin EGF LAG seven-pass G-type receptor 3 | ENCODES a protein that exhibits calcium ion binding (inferred); G protein-coupled receptor activity (inferred); transmembrane signaling receptor activity (inferred); INVOLVED IN axonal fasciculation (ortholog); cilium assembly (ortholog); dopaminergic neuron axon guidance (ortholog); ASSOCIATED WITH autism spectrum disorder (ortholog); bladder exstrophy-epispadias-cloacal exstrophy complex (ortholog); CAKUT1 (ortholog); FOUND IN glutamatergic synapse (ortholog); postsynaptic density membrane (ortholog); presynaptic active zone membrane (ortholog) | NW_004936529 | 437476 | 464012 | Squirrel | 36 | old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 14281816 | CELSR3 | cadherin EGF LAG seven-pass G-type receptor 3 | ENCODES a protein that exhibits calcium ion binding (inferred); G protein-coupled receptor activity (inferred); transmembrane signaling receptor activity (inferred); INVOLVED IN axonal fasciculation (ortholog); cilium assembly (ortholog); dopaminergic neuron axon guidance (ortholog); ASSOCIATED WITH autism spectrum disorder (ortholog); bladder exstrophy-epispadias-cloacal exstrophy complex (ortholog); CAKUT1 (ortholog); FOUND IN glutamatergic synapse (ortholog); postsynaptic density membrane (ortholog); presynaptic active zone membrane (ortholog); INTERACTS WITH deoxynivalenol | | | | Pig | 39 | name | gene, protein-coding, MODEL [RefSeq] |
| 18529261 | CELSR3 | cadherin EGF LAG seven-pass G-type receptor 3 | ENCODES a protein that exhibits calcium ion binding (inferred); G protein-coupled receptor activity (inferred); transmembrane signaling receptor activity (inferred); INVOLVED IN axonal fasciculation (ortholog); cilium assembly (ortholog); dopaminergic neuron axon guidance (ortholog); ASSOCIATED WITH autism spectrum disorder (ortholog); bladder exstrophy-epispadias-cloacal exstrophy complex (ortholog); CAKUT1 (ortholog); FOUND IN glutamatergic synapse (ortholog); postsynaptic density membrane (ortholog); presynaptic active zone membrane (ortholog) | | | | Green Monkey | 35 | name | gene, protein-coding, MODEL [RefSeq] |
| 18913187 | Celsr3 | cadherin EGF LAG seven-pass G-type receptor 3 | ENCODES a protein that exhibits calcium ion binding (inferred); G protein-coupled receptor activity (inferred); secondary active sulfate transmembrane transporter activity (inferred); INVOLVED IN axonal fasciculation (ortholog); cilium assembly (ortholog); dopaminergic neuron axon guidance (ortholog ); ASSOCIATED WITH autism spectrum disorder (ortholog); bladder exstrophy-epispadias-cloacal exstrophy complex (ortholog); CAKUT1 (ortholog); FOUND IN glutamatergic synapse (ortholog); postsynaptic density membrane (ortholog); presynaptic active zone membrane (ortholog) | | | | Naked Mole-Rat | 39 | name | gene, protein-coding, MODEL [RefSeq] |
| 625876224 | Celsr3 | cadherin EGF LAG seven-pass G-type receptor 3 | INVOLVED IN axonal fasciculation (ortholog); cilium assembly (ortholog); dopaminergic neuron axon guidance (ortholog); ASSOCIATED WITH autism spectrum disorder (ortholog); bladder exstrophy-epispadias-cloacal exstrophy complex (ortholog); CAKUT1 (ortholog); FOUND IN glutamatergic synapse (ortholog); postsynaptic density membrane (ortholog); presynaptic active zone membrane (ortholog) | | | | Black Rat | 18 | name | gene, protein-coding, MODEL [RefSeq] |
| 13875718 | LOC102159820 | cadherin EGF LAG seven-pass G-type receptor 1 | ENCODES a protein that exhibits calcium ion binding (inferred); G protein-coupled receptor activity (inferred); transmembrane signaling receptor activity (inferred); INVOLVED IN anterior/posterior pattern specification (ortholog); apical protein localization (ortholog); establishment of body hair pl anar orientation (ortholog); PARTICIPATES IN Wnt signaling, the planar cell polarity pathway; ASSOCIATED WITH bladder exstrophy-epispadias-cloacal exstrophy complex (ortholog); long QT syndrome (ortholog); Lymphatic Malformation 9 (ortholog); FOUND IN membrane (inferred); plasma membrane (inferred); INTERACTS WITH deoxynivalenol | | | | Pig | 57 | old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 1558142 | Celsr1 | cadherin, EGF LAG seven-pass G-type receptor 1 | Predicted to enable calcium ion binding activity. Involved in establishment of planar polarity and neural tube closure. Acts upstream of or within several processes, including apical protein localization; morphogenesis of an epithelium; and motor neuron migration. Located in membrane. Is expressed i n several structures, including central nervous system; epithelium; primitive streak; renal cortex; and skin. Human ortholog(s) of this gene implicated in hereditary lymphedema. Orthologous to human CELSR1 (cadherin EGF LAG seven-pass G-type receptor 1). [provided by Alliance of Genome Resources, Jul 2025] | 15 | 85782959 | 85918424 | Mouse | 250 | old_gene_name , name , description | gene, protein-coding, VALIDATED [RefSeq] |
| 1560078 | Celsr1 | cadherin, EGF LAG seven-pass G-type receptor 1 | ENCODES a protein that exhibits calcium ion binding (inferred); G protein-coupled receptor activity (inferred); transmembrane signaling receptor activity (inferred); INVOLVED IN anterior/posterior pattern specification (ortholog); apical protein localization (ortholog); establishment of body hair pl anar orientation (ortholog); PARTICIPATES IN Wnt signaling, the planar cell polarity pathway; ASSOCIATED WITH bladder exstrophy-epispadias-cloacal exstrophy complex (ortholog); long QT syndrome (ortholog); Lymphatic Malformation 9 (ortholog); FOUND IN membrane (ortholog); plasma membrane (ortholog); INTERACTS WITH 1-naphthyl isothiocyanate; 17beta-estradiol; 17beta-estradiol 3-benzoate | 7 | 118867450 | 119004859 | Rat | 169 | old_gene_name , name | gene, protein-coding, VALIDATED [RefSeq] |
| 69237 | Celsr2 | cadherin, EGF LAG seven-pass G-type receptor 2 | ENCODES a protein that exhibits calcium ion binding (inferred); G protein-coupled receptor activity (inferred); transmembrane signaling receptor activity (inferred); INVOLVED IN dendrite morphogenesis; regulation of cell-cell adhesion; spermatogenesis; ASSOCIATED WITH coronary artery disease (orthol og); Developmental Disabilities (ortholog); endometrial hyperplasia (ortholog); FOUND IN cytoplasm (ortholog); plasma membrane (ortholog); INTERACTS WITH 3,3',4,4',5-pentachlorobiphenyl; acetamide; aflatoxin B1 | 2 | 198717333 | 198741689 | Rat | 148 | old_gene_name , name , old_gene_symbol | gene, protein-coding, PROVISIONAL [RefSeq] |
| 736028 | Celsr2 | cadherin, EGF LAG seven-pass G-type receptor 2 | Predicted to enable G protein-coupled receptor activity and calcium ion binding activity. Involved in several processes, including Wnt signaling pathway; homophilic cell adhesion via plasma membrane adhesion molecules; and neural plate anterior/posterior regionalization. Acts upstream of or within s everal processes, including cerebrospinal fluid secretion; cilium assembly; and nervous system development. Located in cytoplasm and plasma membrane. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; skin; and visual system. Used to study hydrocephalus. Orthologous to human CELSR2 (cadherin EGF LAG seven-pass G-type receptor 2). [provided by Alliance of Genome Resources, Jul 2025] | 3 | 108298164 | 108323416 | Mouse | 154 | old_gene_name , name , description , old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 621787 | Celsr3 | cadherin, EGF LAG seven-pass G-type receptor 3 | ENCODES a protein that exhibits calcium ion binding (inferred); G protein-coupled receptor activity (inferred); transmembrane signaling receptor activity (inferred); INVOLVED IN axonal fasciculation (ortholog); cilium assembly (ortholog); dopaminergic neuron axon guidance (ortholog); ASSOCIATED WITH autism spectrum disorder (ortholog); bladder exstrophy-epispadias-cloacal exstrophy complex (ortholog); CAKUT1 (ortholog); FOUND IN glutamatergic synapse (ortholog); postsynaptic density membrane (ortholog); presynaptic active zone membrane (ortholog); INTERACTS WITH ammonium chloride; atrazine; bis(2-ethylhexyl) phthalate | 8 | 118409136 | 118438593 | Rat | 128 | old_gene_name , name , old_gene_symbol | gene, protein-coding, PROVISIONAL [RefSeq] |
| 732288 | Celsr3 | cadherin, EGF LAG seven-pass G-type receptor 3 | Predicted to enable G protein-coupled receptor activity and calcium ion binding activity. Involved in Wnt signaling pathway, planar cell polarity pathway; dopaminergic neuron axon guidance; and serotonergic neuron axon guidance. Acts upstream of or within several processes, including cilium assembly ; generation of neurons; and regulation of protein phosphorylation. Is active in glutamatergic synapse; postsynaptic density membrane; and presynaptic active zone membrane. Is expressed in several structures, including central nervous system; embryo ectoderm; epiblast; peripheral nervous system; and retina. Orthologous to human CELSR3 (cadherin EGF LAG seven-pass G-type receptor 3). [provided by Alliance of Genome Resources, Jul 2025] | 9 | 108703244 | 108730168 | Mouse | 151 | old_gene_name , name , description | gene, protein-coding, VALIDATED [RefSeq] |
| 1557383 | Edil3 | EGF-like repeats and discoidin I-like domains 3 | Predicted to enable calcium ion binding activity. Acts upstream of or within positive regulation of cell-substrate adhesion. Predicted to be located in extracellular region. Is expressed in several structures, including cartilage; cerebral cortex; heart; skeletal system; and trachea. Orthologous to human EDIL3 (EGF like repeats and discoidin domains 3). [provided by Alliance of Genome Resources, Apr 2025] | 13 | 88969591 | 89471344 | Mouse | 656 | old_gene_name , name , description | gene, protein-coding, VALIDATED [RefSeq] |
| 1308528 | Efemp1 | EGF-like fibulin extracellular matrix protein 1 | ENCODES a protein that exhibits epidermal growth factor receptor activity (ortholog); epidermal growth factor receptor binding (ortholog); INVOLVED IN negative regulation of neuron projection development; positive regulation of cell population proliferation; positive regulation of cell projection or ganization; ASSOCIATED WITH adenocarcinoma (ortholog); adenoma (ortholog); Animal Mammary Neoplasms (ortholog); FOUND IN basement membrane; extracellular matrix (ortholog); extracellular space (ortholog); INTERACTS WITH 17alpha-ethynylestradiol; 2,2',4,4'-Tetrabromodiphenyl ether; 2,3,7,8-tetrachlorodibenzodioxine | 14 | 106811769 | 106890961 | Rat | 253 | old_gene_name , name | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1318351 | EFEMP1 | EGF-like fibulin extracellular matrix protein 1 | This gene encodes a member of the fibulin family of extracellular matrix glycoproteins. Like all members of this family, the encoded protein contains tandemly repeated epidermal growth factor-like repeats followed by a C-terminus fibulin-type domain. This gene is upregulated in malignant gliomas and may play a role in the aggressive nature of these tumors. Mutations in this gene are associated with Doyne honeycomb retinal dystrophy. Alternatively spliced transcript variants that encode the same protein have been described.[provided by RefSeq, Nov 2009] | 2 | 55865967 | 55923782 | Human | 500 | old_gene_name , name | gene, protein-coding, REVIEWED [RefSeq] |
| 9009403 | Efemp1 | EGF-like fibulin extracellular matrix protein 1 | ENCODES a protein that exhibits epidermal growth factor receptor activity (ortholog); epidermal growth factor receptor binding (ortholog); INVOLVED IN camera-type eye development (ortholog); embryonic eye morphogenesis (ortholog); epidermal growth factor receptor signaling pathway (ortholog); ASSOCI ATED WITH adenocarcinoma (ortholog); adenoma (ortholog); Animal Mammary Neoplasms (ortholog); FOUND IN basement membrane (ortholog); extracellular matrix (ortholog); extracellular space (ortholog) | NW_004955424 | 27181717 | 27240067 | Chinchilla | 66 | old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 12686414 | Efemp1 | EGF-like fibulin extracellular matrix protein 1 | ENCODES a protein that exhibits calcium ion binding (inferred); epidermal growth factor receptor activity (inferred); epidermal growth factor receptor binding (inferred); INVOLVED IN negative regulation of neuron projection development (ortholog); peptidyl-tyrosine phosphorylation (ortholog); positi ve regulation of cell population proliferation (ortholog); ASSOCIATED WITH adenocarcinoma (ortholog); adenoma (ortholog); Animal Mammary Neoplasms (ortholog); FOUND IN basement membrane (ortholog) | NW_004936491 | 2159654 | 2214480 | Squirrel | 69 | old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 18663065 | EFEMP1 | EGF-like fibulin extracellular matrix protein 1 | ENCODES a protein that exhibits calcium ion binding (inferred); epidermal growth factor receptor activity (inferred); epidermal growth factor receptor binding (inferred); INVOLVED IN negative regulation of neuron projection development (ortholog); peptidyl-tyrosine phosphorylation (ortholog); positi ve regulation of cell population proliferation (ortholog); ASSOCIATED WITH adenocarcinoma (ortholog); adenoma (ortholog); Animal Mammary Neoplasms (ortholog); FOUND IN basement membrane (ortholog) | | | | Green Monkey | 69 | old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 626064969 | Efemp1 | EGF-like fibulin extracellular matrix protein 1 | ENCODES a protein that exhibits epidermal growth factor receptor activity (ortholog); epidermal growth factor receptor binding (ortholog); INVOLVED IN camera-type eye development (ortholog); embryonic eye morphogenesis (ortholog); epidermal growth factor receptor signaling pathway (ortholog); ASSOCI ATED WITH adenocarcinoma (ortholog); adenoma (ortholog); Animal Mammary Neoplasms (ortholog); FOUND IN basement membrane (ortholog); extracellular matrix (ortholog); extracellular space (ortholog) | | | | Black Rat | 66 | old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 1349728 | EFEMP2 | EGF-like fibulin extracellular matrix protein 2 | A large number of extracellular matrix proteins have been found to contain variations of the epidermal growth factor (EGF) domain and have been implicated in functions as diverse as blood coagulation, activation of complement and determination of cell fate durin g development. The protein encoded by this gene contains four EGF2 domains and six calcium-binding EGF2 domains. This gene is necessary for elastic fiber formation and connective tissue development. Defects in this gene are cause of an autosomal recessive cutis laxa syndrome. Alternatively spliced transcript variants have been identified for this gene. [provided by RefSeq, Jan 2011] | 11 | 65866441 | 65872800 | Human | 413 | old_gene_name , name , description | gene, protein-coding, REVIEWED [RefSeq] |
| 1359496 | Efemp2 | EGF-like fibulin extracellular matrix protein 2 | ENCODES a protein that exhibits heparin binding (ortholog); protein homodimerization activity (ortholog); INVOLVED IN aorta development (ortholog); aorta smooth muscle tissue morphogenesis (ortholog); artery development (ortholog); ASSOCIATED WITH osteoarthritis; aortic aneurysm (ortholog); aortic d isease (ortholog); FOUND IN basement membrane (ortholog); elastic fiber (ortholog); extracellular matrix (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; acetamide; acrylamide | 1 | 212211057 | 212218739 | Rat | 159 | old_gene_name , name | gene, protein-coding, VALIDATED [RefSeq] |
| 9013676 | Efemp2 | EGF-like fibulin extracellular matrix protein 2 | ENCODES a protein that exhibits heparin binding (ortholog); protein homodimerization activity (ortholog); INVOLVED IN aorta development (ortholog); aorta smooth muscle tissue morphogenesis (ortholog); artery development (ortholog); ASSOCIATED WITH aortic aneurysm (ortholog); aortic disease (ortholog ); aortic dissection (ortholog); FOUND IN basement membrane (ortholog); elastic fiber (ortholog); extracellular matrix (ortholog) | NW_004955422 | 19463090 | 19470605 | Chinchilla | 62 | old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 12614945 | Efemp2 | EGF-like fibulin extracellular matrix protein 2 | ENCODES a protein that exhibits calcium ion binding (inferred); heparin binding (inferred); protein homodimerization activity (inferred); INVOLVED IN artery development (ortholog); elastic fiber assembly (ortholog); ASSOCIATED WITH aortic aneurysm (ortholog); aortic disease (ortholog); aortic dissec tion (ortholog); FOUND IN basement membrane (inferred); elastic fiber (inferred); extracellular matrix (inferred) | NW_004936599 | 3663288 | 3670048 | Squirrel | 64 | old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 18509591 | EFEMP2 | EGF-like fibulin extracellular matrix protein 2 | ENCODES a protein that exhibits calcium ion binding (inferred); heparin binding (inferred); protein homodimerization activity (inferred); INVOLVED IN artery development (ortholog); elastic fiber assembly (ortholog); ASSOCIATED WITH aortic aneurysm (ortholog); aortic disease (ortholog); aortic dissec tion (ortholog); FOUND IN basement membrane (inferred); elastic fiber (inferred); extracellular matrix (inferred) | | | | Green Monkey | 63 | old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 18916313 | Efemp2 | EGF-like fibulin extracellular matrix protein 2 | ENCODES a protein that exhibits calcium ion binding (inferred); heparin binding (inferred); protein homodimerization activity (inferred); INVOLVED IN artery development (ortholog); elastic fiber assembly (ortholog); ASSOCIATED WITH aortic aneurysm (ortholog); aortic disease (ortholog); aortic dissec tion (ortholog); FOUND IN basement membrane (inferred); elastic fiber (inferred); extracellular matrix (inferred) | | | | Naked Mole-Rat | 65 | old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 1603594 | EGFEM1P | EGF like and EMI domain containing 1, pseudogene | Predicted to enable scavenger receptor activity. Predicted to be involved in vesicle-mediated transport. [provided by Alliance of Genome Resources, Jul 2025] | 3 | 168249522 | 168830599 | Human | 27 | symbol , COSMIC , name , Human Proteome Map | gene, pseudo, VALIDATED [RefSeq] |
| 38656340 | LOC100421064 | sushi, nidogen and EGF like domains 1 pseudogene | | 19 | 35075798 | 35076483 | Human | | name | gene, pseudo, INFERRED [RefSeq] |
| 1558285 | Heg1 | heart development protein with EGF-like domains 1 | Predicted to enable calcium ion binding activity. Acts upstream of or within several processes, including circulatory system development; endothelial cell morphogenesis; and lymph circulation. Located in cell-cell junction and external side of plasma membrane. Is expressed in several structures, inc luding alimentary system; brain; cardiovascular system; genitourinary system; and hemolymphoid system. Orthologous to human HEG1 (heart development protein with EGF like domains 1). [provided by Alliance of Genome Resources, Jul 2025] | 16 | 33504754 | 33591946 | Mouse | 189 | name , description | gene, protein-coding, VALIDATED [RefSeq] |
| 1564641 | Heg1 | heart development protein with EGF-like domains 1 | ENCODES a protein that exhibits calcium ion binding (inferred); INVOLVED IN cardiac atrium morphogenesis (ortholog); cardiac muscle tissue growth (ortholog); cell-cell junction organization (ortholog); FOUND IN cell surface (ortholog); cell-cell junction (ortholog); external side of plasma membrane (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; acrolein; amphetamine | 11 | 80512096 | 80600150 | Rat | 147 | name | gene, protein-coding, VALIDATED [RefSeq] |
| 1603204 | HEG1 | heart development protein with EGF like domains 1 | Predicted to enable calcium ion binding activity. Involved in several processes, including negative regulation of Rho protein signal transduction; negative regulation of Rho-dependent protein serine/threonine kinase activity; and negative regulation of membrane permeability. Located in cell-cell jun ction. [provided by Alliance of Genome Resources, Jul 2025] | 3 | 124965710 | 125055997 | Human | 151 | old_gene_name , name | gene, protein-coding, VALIDATED [RefSeq] |
| 8903647 | Heg1 | heart development protein with EGF like domains 1 | INVOLVED IN cardiac atrium morphogenesis (ortholog); cardiac muscle tissue growth (ortholog); cell-cell junction organization (ortholog); FOUND IN cell surface (ortholog); cell-cell junction (ortholog); external side of plasma membrane (ortholog) | NW_004955427 | 24035193 | 24115483 | Chinchilla | 36 | old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 11966453 | HEG1 | heart development protein with EGF like domains 1 | ENCODES a protein that exhibits calcium ion binding (inferred); INVOLVED IN cardiac atrium morphogenesis (ortholog); cardiac muscle tissue growth (ortholog); cell-cell junction organization (ortholog); FOUND IN anchoring junction (inferred); cell surface (inferred); cell-cell junction (inferred) | 3 | 122091832 | 122204436 | Bonobo | 41 | name | gene, protein-coding, MODEL [RefSeq] |
| 12417152 | HEG1 | heart development protein with EGF like domains 1 | ENCODES a protein that exhibits calcium ion binding (inferred); INVOLVED IN cardiac atrium morphogenesis (ortholog); cardiac muscle tissue growth (ortholog); cell-cell junction organization (ortholog); FOUND IN anchoring junction (inferred); cell surface (inferred); cell-cell junction (inferred) | 33 | 27982127 | 28044379 | Dog | 41 | name | gene, protein-coding, MODEL [RefSeq] |
| 12560084 | Heg1 | heart development protein with EGF like domains 1 | ENCODES a protein that exhibits calcium ion binding (inferred); INVOLVED IN cardiac atrium morphogenesis (ortholog); cardiac muscle tissue growth (ortholog); cell-cell junction organization (ortholog); FOUND IN anchoring junction (inferred); cell surface (inferred); cell-cell junction (inferred) | NW_004936725 | 261809 | 336390 | Squirrel | 41 | name | gene, protein-coding, MODEL [RefSeq] |
| 14157721 | HEG1 | heart development protein with EGF like domains 1 | ENCODES a protein that exhibits calcium ion binding (inferred); INVOLVED IN cardiac atrium morphogenesis (ortholog); cardiac muscle tissue growth (ortholog); cell-cell junction organization (ortholog); FOUND IN cell surface (inferred); cell-cell junction (inferred); external side of plasma membrane (inferred) | | | | Pig | 38 | name | gene, protein-coding, MODEL [RefSeq] |
| 18531670 | HEG1 | heart development protein with EGF like domains 1 | ENCODES a protein that exhibits calcium ion binding (inferred); INVOLVED IN cardiac atrium morphogenesis (ortholog); cardiac muscle tissue growth (ortholog); cell-cell junction organization (ortholog); FOUND IN anchoring junction (inferred); cell surface (inferred); cell-cell junction (inferred) | | | | Green Monkey | 41 | name | gene, protein-coding, MODEL [RefSeq] |
| 18916940 | Heg1 | heart development protein with EGF like domains 1 | ENCODES a protein that exhibits calcium ion binding (inferred); INVOLVED IN cardiac atrium morphogenesis (ortholog); cardiac muscle tissue growth (ortholog); cell-cell junction organization (ortholog); FOUND IN cell surface (ortholog); external side of plasma membrane (ortholog) | | | | Naked Mole-Rat | 40 | name | gene, protein-coding, MODEL [RefSeq] |
| 625932298 | Heg1 | heart development protein with EGF like domains 1 | INVOLVED IN cardiac atrium morphogenesis (ortholog); cardiac muscle tissue growth (ortholog); cell-cell junction organization (ortholog); FOUND IN cell surface (ortholog); cell-cell junction (ortholog); external side of plasma membrane (ortholog) | | | | Black Rat | 36 | name | gene, protein-coding, MODEL [RefSeq] |
| 14087403 | LOC110260610 | cadherin EGF LAG seven-pass G-type receptor 1-like | ENCODES a protein that exhibits calcium ion binding (inferred); INVOLVED IN cell adhesion (inferred); homophilic cell-cell adhesion (inferred); FOUND IN membrane (inferred); plasma membrane (inferred) | | | | Pig | 8 | name | gene, protein-coding, MODEL [RefSeq] |
| 625882633 | LOC116890119 | cadherin EGF LAG seven-pass G-type receptor 1-like | | | | | Black Rat | | name | gene, protein-coding, MODEL [RefSeq] |
| 40895647 | LOC119623318 | cadherin EGF LAG seven-pass G-type receptor 2-like | | | | | Green Monkey | | name | gene, pseudo, MODEL [RefSeq] |
| 124891373 | LOC120891565 | cadherin EGF LAG seven-pass G-type receptor 2-like | ENCODES a protein that exhibits calcium ion binding (inferred); INVOLVED IN cell adhesion (inferred); homophilic cell-cell adhesion (inferred); FOUND IN membrane (inferred); plasma membrane (inferred) | | | | Squirrel | 7 | name | gene, protein-coding, MODEL [RefSeq] |
| 329344952 | LOC129395024 | cadherin EGF LAG seven-pass G-type receptor 1-like | | | | | Bonobo | | name | gene, protein-coding, MODEL [RefSeq] |
| 598131230 | LOC140709118 | cadherin EGF LAG seven-pass G-type receptor 2-like | | | | | Green Monkey | | old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 1306592 | Egflam | EGF-like, fibronectin type III and laminin G domains | ENCODES a protein that exhibits glycosaminoglycan binding (ortholog); molecular adaptor activity (ortholog); INVOLVED IN extracellular matrix organization (ortholog); positive regulation of cell-substrate adhesion (ortholog); synapse assembly (ortholog); ASSOCIATED WITH High Myopia (ortholog); FOUND IN basement membrane (ortholog); cell surface (ortholog); extracellular matrix (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 3,3',4,4',5-pentachlorobiphenyl; amitrole | 2 | 58029934 | 58204010 | Rat | 112 | symbol , old_gene_name , PhenoGen , name | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1332080 | Egflam | EGF-like, fibronectin type III and laminin G domains | Enables glycosaminoglycan binding activity. Acts upstream of or within extracellular matrix organization and positive regulation of cell-substrate adhesion. Located in basement membrane and interstitial matrix. Is active in photoreceptor ribbon synapse. Is expressed in hair follicle and rib. Ortholo gous to human EGFLAM (EGF like, fibronectin type III and laminin G domains). [provided by Alliance of Genome Resources, Jul 2025] | 15 | 7235598 | 7428203 | Mouse | 108 | symbol , old_gene_name , PhenoGen , name , description | gene, protein-coding, VALIDATED [RefSeq] |
| 1602070 | EGFLAM | EGF like, fibronectin type III and laminin G domains | Predicted to enable calcium ion binding activity and glycosaminoglycan binding activity. Predicted to act upstream of or within extracellular matrix organization and positive regulation of cell-substrate adhesion. Part of cell surface. [provided by Alliance of Genome Resources, Jul 2025] | 5 | 38258559 | 38465480 | Human | 104 | symbol , old_gene_name , COSMIC , name , Human Proteome Map | gene, protein-coding, VALIDATED [RefSeq] |
| 8994315 | Egflam | EGF like, fibronectin type III and laminin G domains | ENCODES a protein that exhibits glycosaminoglycan binding (ortholog); molecular adaptor activity (ortholog); INVOLVED IN extracellular matrix organization (ortholog); positive regulation of cell-substrate adhesion (ortholog); synapse assembly (ortholog); ASSOCIATED WITH High Myopia (ortholog); FOUND IN basement membrane (ortholog); cell surface (ortholog); extracellular matrix (ortholog) | NW_004955426 | 22856515 | 23030517 | Chinchilla | 17 | symbol , old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 11670475 | EGFLAM | EGF like, fibronectin type III and laminin G domains | ENCODES a protein that exhibits calcium ion binding (inferred); glycosaminoglycan binding (inferred); molecular adaptor activity (inferred); INVOLVED IN extracellular matrix organization (ortholog); positive regulation of cell-substrate adhesion (ortholog); ASSOCIATED WITH High Myopia (ortholog); FO UND IN cell surface (ortholog); photoreceptor ribbon synapse (ortholog) | 5 | 71909106 | 72119958 | Bonobo | 21 | symbol , name | gene, protein-coding, MODEL [RefSeq] |
| 12282683 | EGFLAM | EGF like, fibronectin type III and laminin G domains | ENCODES a protein that exhibits calcium ion binding (inferred); glycosaminoglycan binding (inferred); molecular adaptor activity (inferred); INVOLVED IN extracellular matrix organization (ortholog); positive regulation of cell-substrate adhesion (ortholog); ASSOCIATED WITH High Myopia (ortholog); FO UND IN cell surface (ortholog); photoreceptor ribbon synapse (ortholog) | 4 | 70391657 | 70574629 | Dog | 27 | symbol , name | gene, protein-coding, MODEL [RefSeq] |
| 12693971 | Egflam | EGF like, fibronectin type III and laminin G domains | ENCODES a protein that exhibits calcium ion binding (inferred); glycosaminoglycan binding (inferred); molecular adaptor activity (inferred); INVOLVED IN extracellular matrix organization (ortholog); positive regulation of cell-substrate adhesion (ortholog); ASSOCIATED WITH High Myopia (ortholog); FO UND IN cell surface (ortholog); photoreceptor ribbon synapse (ortholog) | NW_004936518 | 3706818 | 3882308 | Squirrel | 21 | symbol , name | gene, protein-coding, MODEL [RefSeq] |
| 14175413 | EGFLAM | EGF like, fibronectin type III and laminin G domains | ENCODES a protein that exhibits calcium ion binding (inferred); glycosaminoglycan binding (inferred); molecular adaptor activity (inferred); INVOLVED IN extracellular matrix organization (ortholog); positive regulation of cell-substrate adhesion (ortholog); ASSOCIATED WITH High Myopia (ortholog); FO UND IN cell surface (ortholog); photoreceptor ribbon synapse (ortholog) | | | | Pig | 26 | symbol , name | gene, protein-coding, MODEL [RefSeq] |
| 18730996 | EGFLAM | EGF like, fibronectin type III and laminin G domains | ENCODES a protein that exhibits calcium ion binding (inferred); glycosaminoglycan binding (inferred); molecular adaptor activity (inferred); INVOLVED IN extracellular matrix organization (ortholog); positive regulation of cell-substrate adhesion (ortholog); ASSOCIATED WITH High Myopia (ortholog); FO UND IN cell surface (ortholog); photoreceptor ribbon synapse (ortholog) | | | | Green Monkey | 21 | symbol , name | gene, protein-coding, MODEL [RefSeq] |
| 18924549 | Egflam | EGF like, fibronectin type III and laminin G domains | ENCODES a protein that exhibits glycosaminoglycan binding (ortholog); molecular adaptor activity (ortholog); INVOLVED IN extracellular matrix organization (ortholog); positive regulation of cell-substrate adhesion (ortholog); synapse assembly (ortholog); ASSOCIATED WITH High Myopia (ortholog); FOUND IN cell surface (ortholog); extracellular matrix (ortholog); interstitial matrix (ortholog) | | | | Naked Mole-Rat | 19 | symbol , name | gene, protein-coding, MODEL [RefSeq] |
| 626016533 | Egflam | EGF like, fibronectin type III and laminin G domains | ENCODES a protein that exhibits glycosaminoglycan binding (ortholog); molecular adaptor activity (ortholog); INVOLVED IN extracellular matrix organization (ortholog); positive regulation of cell-substrate adhesion (ortholog); synapse assembly (ortholog); ASSOCIATED WITH High Myopia (ortholog); FOUND IN basement membrane (ortholog); cell surface (ortholog); extracellular matrix (ortholog) | | | | Black Rat | 17 | symbol , name | gene, protein-coding, MODEL [RefSeq] |
| 18928466 | LOC101705728 | proheparin-binding EGF-like growth factor pseudogene | | | | | Naked Mole-Rat | | name | gene, pseudo, MODEL [RefSeq] |
| 11983897 | EFEMP1 | EGF containing fibulin extracellular matrix protein 1 | ENCODES a protein that exhibits calcium ion binding (inferred); epidermal growth factor receptor activity (inferred); epidermal growth factor receptor binding (inferred); INVOLVED IN negative regulation of neuron projection development (ortholog); peptidyl-tyrosine phosphorylation (ortholog); positi ve regulation of cell population proliferation (ortholog); ASSOCIATED WITH adenocarcinoma (ortholog); adenoma (ortholog); Animal Mammary Neoplasms (ortholog); FOUND IN basement membrane (ortholog) | 2A | 56017678 | 56076059 | Bonobo | 70 | old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 12123764 | EFEMP1 | EGF containing fibulin extracellular matrix protein 1 | ENCODES a protein that exhibits calcium ion binding (inferred); epidermal growth factor receptor activity (inferred); epidermal growth factor receptor binding (inferred); INVOLVED IN negative regulation of neuron projection development (ortholog); peptidyl-tyrosine phosphorylation (ortholog); positi ve regulation of cell population proliferation (ortholog); ASSOCIATED WITH adenocarcinoma (ortholog); adenoma (ortholog); Animal Mammary Neoplasms (ortholog); FOUND IN basement membrane (ortholog); INTERACTS WITH bisphenol A | 10 | 56632801 | 56694872 | Dog | 73 | old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 14046030 | EFEMP1 | EGF containing fibulin extracellular matrix protein 1 | ENCODES a protein that exhibits calcium ion binding (inferred); epidermal growth factor receptor activity (inferred); epidermal growth factor receptor binding (inferred); INVOLVED IN negative regulation of neuron projection development (ortholog); peptidyl-tyrosine phosphorylation (ortholog); positi ve regulation of cell population proliferation (ortholog); ASSOCIATED WITH adenocarcinoma (ortholog); adenoma (ortholog); Animal Mammary Neoplasms (ortholog); FOUND IN basement membrane (ortholog) | | | | Pig | 72 | old_gene_name , name | gene, protein-coding, VALIDATED [RefSeq] |
| 18917840 | Efemp1 | EGF containing fibulin extracellular matrix protein 1 | ENCODES a protein that exhibits calcium ion binding (inferred); epidermal growth factor receptor activity (inferred); epidermal growth factor receptor binding (inferred); INVOLVED IN negative regulation of neuron projection development (ortholog); peptidyl-tyrosine phosphorylation (ortholog); positi ve regulation of cell population proliferation (ortholog); ASSOCIATED WITH adenocarcinoma (ortholog); adenoma (ortholog); Animal Mammary Neoplasms (ortholog); FOUND IN basement membrane (ortholog) | | | | Naked Mole-Rat | 70 | old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 11912843 | EFEMP2 | EGF containing fibulin extracellular matrix protein 2 | ENCODES a protein that exhibits calcium ion binding (inferred); heparin binding (inferred); protein homodimerization activity (inferred); INVOLVED IN artery development (ortholog); elastic fiber assembly (ortholog); ASSOCIATED WITH aortic aneurysm (ortholog); aortic disease (ortholog); aortic dissec tion (ortholog); FOUND IN basement membrane (inferred); elastic fiber (inferred); extracellular matrix (inferred) | 11 | 61226755 | 61233181 | Bonobo | 64 | old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 12270345 | EFEMP2 | EGF containing fibulin extracellular matrix protein 2 | ENCODES a protein that exhibits calcium ion binding (inferred); heparin binding (inferred); protein homodimerization activity (inferred); INVOLVED IN artery development (ortholog); elastic fiber assembly (ortholog); ASSOCIATED WITH aortic aneurysm (ortholog); aortic disease (ortholog); aortic dissec tion (ortholog); FOUND IN basement membrane (inferred); elastic fiber (inferred); extracellular matrix (inferred) | 18 | 51389797 | 51396109 | Dog | 67 | old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 14003514 | EFEMP2 | EGF containing fibulin extracellular matrix protein 2 | ENCODES a protein that exhibits calcium ion binding (inferred); heparin binding (inferred); protein homodimerization activity (inferred); INVOLVED IN artery development (ortholog); elastic fiber assembly (ortholog); ASSOCIATED WITH aortic aneurysm (ortholog); aortic disease (ortholog); aortic dissec tion (ortholog); FOUND IN basement membrane (inferred); elastic fiber (inferred); extracellular matrix (inferred); INTERACTS WITH deoxynivalenol | | | | Pig | 68 | old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 625920221 | Efemp2 | EGF containing fibulin extracellular matrix protein 2 | ENCODES a protein that exhibits heparin binding (ortholog); protein homodimerization activity (ortholog); INVOLVED IN aorta development (ortholog); aorta smooth muscle tissue morphogenesis (ortholog); artery development (ortholog); ASSOCIATED WITH aortic aneurysm (ortholog); aortic disease (ortholog ); aortic dissection (ortholog); FOUND IN basement membrane (ortholog); elastic fiber (ortholog); extracellular matrix (ortholog) | | | | Black Rat | 62 | old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 8867999 | LOC102013061 | cysteine-rich with EGF-like domain protein 2 pseudogene | | NW_004955409 | 26647055 | 26648471 | Chinchilla | | name | gene, pseudo, MODEL [RefSeq] |
| 3083 | Mfge8 | milk fat globule EGF and factor V/VIII domain containing | ENCODES a protein that exhibits integrin binding (ortholog); phosphatidylethanolamine binding (ortholog); phosphatidylserine binding (ortholog); INVOLVED IN positive regulation of cell population proliferation; response to estrogen; apoptotic cell clearance (ortholog); ASSOCIATED WITH Breast Neoplas ms (ortholog); colorectal cancer (ortholog); Experimental Diabetes Mellitus (ortholog); FOUND IN external side of plasma membrane (ortholog); extracellular space (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,6-dinitrotoluene; 3-chloropropane-1,2-diol | 1 | 142474027 | 142489431 | Rat | 183 | old_gene_name , name | gene, protein-coding, VALIDATED [RefSeq] |
| 10895 | Mfge8 | milk fat globule EGF and factor V/VIII domain containing | Enables integrin binding activity. Involved in apoptotic cell clearance. Located in external side of plasma membrane and extracellular space. Is expressed in several structures, including central nervous system; extraembryonic component; hemolymphoid system; integumental system; and reproductive sys tem. Human ortholog(s) of this gene implicated in temporal arteritis. Orthologous to human MFGE8 (milk fat globule EGF and factor V/VIII domain containing). [provided by Alliance of Genome Resources, Jul 2025] | 7 | 78783516 | 78798808 | Mouse | 224 | old_gene_name , name , description | gene, protein-coding, VALIDATED [RefSeq] |
| 736002 | MFGE8 | milk fat globule EGF and factor V/VIII domain containing | This gene encodes a preproprotein that is proteolytically processed to form multiple protein products. The major encoded protein product, lactadherin, is a membrane glycoprotein that promotes phagocytosis of apoptotic cells. This protein has also been implicated in wound healing, autoimmune disease, and cancer. Lactadherin can be further processed to form a smaller cleavage product, medin, which comprises the major protein component of aortic medial amyloid (AMA). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2015] | 15 | 88898683 | 88913379 | Human | 186 | name , ensembl_full_name | gene, protein-coding, REVIEWED [RefSeq] |
| 8984360 | Mfge8 | milk fat globule EGF and factor V/VIII domain containing | ENCODES a protein that exhibits integrin binding (ortholog); phosphatidylethanolamine binding (ortholog); phosphatidylserine binding (ortholog); INVOLVED IN apoptotic cell clearance (ortholog); phagocytosis, engulfment (ortholog); phagocytosis, recognition (ortholog); ASSOCIATED WITH Breast Neoplasm s (ortholog); colorectal cancer (ortholog); Experimental Diabetes Mellitus (ortholog); FOUND IN external side of plasma membrane (ortholog); extracellular space (ortholog) | NW_004955416 | 16092263 | 16103097 | Chinchilla | 17 | name , ensembl_full_name | gene, protein-coding, MODEL [RefSeq] |
| 11872471 | MFGE8 | milk fat globule EGF and factor V/VIII domain containing | ENCODES a protein that exhibits phosphatidylethanolamine binding (ortholog); INVOLVED IN phagocytosis, engulfment (ortholog); phagocytosis, recognition (ortholog); positive regulation of cell population proliferation (ortholog); ASSOCIATED WITH Breast Neoplasms (ortholog); colorectal cancer (ortholo g); Experimental Diabetes Mellitus (ortholog); FOUND IN endomembrane system (inferred); external side of plasma membrane (inferred); extracellular region (inferred) | 15 | 67587360 | 67602029 | Bonobo | 21 | name , ensembl_full_name | gene, protein-coding, MODEL [RefSeq] |
| 12175263 | MFGE8 | milk fat globule EGF and factor V/VIII domain containing | ENCODES a protein that exhibits phosphatidylethanolamine binding (ortholog); INVOLVED IN phagocytosis, engulfment (ortholog); phagocytosis, recognition (ortholog); positive regulation of cell population proliferation (ortholog); ASSOCIATED WITH Breast Neoplasms (ortholog); colorectal cancer (ortholo g); Experimental Diabetes Mellitus (ortholog); FOUND IN endomembrane system (inferred); external side of plasma membrane (inferred); extracellular region (inferred) | 3 | 52054243 | 52064423 | Dog | 24 | name , ensembl_full_name | gene, protein-coding, MODEL [RefSeq] |
| 12593627 | Mfge8 | milk fat globule EGF and factor V/VIII domain containing | ENCODES a protein that exhibits phosphatidylethanolamine binding (ortholog); INVOLVED IN phagocytosis, engulfment (ortholog); phagocytosis, recognition (ortholog); positive regulation of cell population proliferation (ortholog); ASSOCIATED WITH Breast Neoplasms (ortholog); colorectal cancer (ortholo g); Experimental Diabetes Mellitus (ortholog); FOUND IN external side of plasma membrane (inferred); extracellular space (inferred); plasma membrane (inferred) | NW_004936483 | 14868171 | 14880552 | Squirrel | 19 | old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 14054876 | MFGE8 | milk fat globule EGF and factor V/VIII domain containing | ENCODES a protein that exhibits phosphatidylethanolamine binding (ortholog); INVOLVED IN phagocytosis, engulfment (ortholog); phagocytosis, recognition (ortholog); positive regulation of cell population proliferation (ortholog); ASSOCIATED WITH Breast Neoplasms (ortholog); colorectal cancer (ortholo g); Experimental Diabetes Mellitus (ortholog); FOUND IN acrosomal membrane (inferred); cytoplasmic vesicle (inferred); endomembrane system (inferred) | | | | Pig | 26 | name , ensembl_full_name | gene, protein-coding, PROVISIONAL [RefSeq] |
| 18925856 | Mfge8 | milk fat globule EGF and factor V/VIII domain containing | ENCODES a protein that exhibits integrin binding (ortholog); phosphatidylethanolamine binding (ortholog); phosphatidylserine binding (ortholog); INVOLVED IN apoptotic cell clearance (ortholog); phagocytosis, engulfment (ortholog); phagocytosis, recognition (ortholog); ASSOCIATED WITH Breast Neoplasm s (ortholog); colorectal cancer (ortholog); Experimental Diabetes Mellitus (ortholog); FOUND IN external side of plasma membrane (ortholog); extracellular space (ortholog) | | | | Naked Mole-Rat | 22 | old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 20867343 | MFGE8 | milk fat globule EGF and factor V/VIII domain containing | ENCODES a protein that exhibits phosphatidylserine binding (inferred); signaling receptor activity (inferred); INVOLVED IN cell adhesion (inferred); FOUND IN plasma membrane (inferred) | | | | Green Monkey | 4 | old_gene_name , name | gene, protein-coding |
| 40892809 | MFGE8 | milk fat globule EGF and factor V/VIII domain containing | ENCODES a protein that exhibits integrin binding (ortholog); phosphatidylethanolamine binding (ortholog); phosphatidylserine binding (ortholog); INVOLVED IN apoptotic cell clearance (ortholog); phagocytosis, engulfment (ortholog); phagocytosis, recognition (ortholog); ASSOCIATED WITH Breast Neoplasm s (ortholog); colorectal cancer (ortholog); Experimental Diabetes Mellitus (ortholog); FOUND IN external side of plasma membrane (ortholog); extracellular space (ortholog) | | | | Green Monkey | 17 | name | gene, protein-coding, MODEL [RefSeq] |
| 626099289 | Mfge8 | milk fat globule EGF and factor V/VIII domain containing | ENCODES a protein that exhibits integrin binding (ortholog); phosphatidylethanolamine binding (ortholog); phosphatidylserine binding (ortholog); INVOLVED IN apoptotic cell clearance (ortholog); phagocytosis, engulfment (ortholog); phagocytosis, recognition (ortholog); ASSOCIATED WITH Breast Neoplasm s (ortholog); colorectal cancer (ortholog); Experimental Diabetes Mellitus (ortholog); FOUND IN external side of plasma membrane (ortholog); extracellular space (ortholog) | | | | Black Rat | 17 | name | gene, protein-coding, MODEL [RefSeq] |
| 1309015 | Scube1 | signal peptide, CUB domain and EGF like domain containing 1 | ENCODES a protein that exhibits identical protein binding (ortholog); INVOLVED IN positive regulation of smoothened signaling pathway (ortholog); FOUND IN cell surface (ortholog); external side of plasma membrane (ortholog); extracellular space (ortholog); INTERACTS WITH 6-propyl-2-thiouracil; atraz ine; bisphenol A | 7 | 116639027 | 116760986 | Rat | 82 | old_gene_name , name | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1319121 | SCUBE1 | signal peptide, CUB domain and EGF like domain containing 1 | This gene encodes a cell surface glycoprotein that is a member of the SCUBE (signal peptide, CUB domain, EGF (epidermal growth factor)-like protein) family. Family members have an amino-terminal signal peptide, nine copies of EGF span>-like repeats and a CUB domain at the carboxyl terminus. This protein is expressed in platelets and endothelial cells and may play an important role in vascular biology. [provided by RefSeq, Oct 2011] | 22 | 43197280 | 43343372 | Human | 85 | old_gene_name , name , description | gene, protein-coding, REVIEWED [RefSeq] |
| 8712714 | Scube1 | signal peptide, CUB domain and EGF like domain containing 1 | ENCODES a protein that exhibits identical protein binding (ortholog); INVOLVED IN positive regulation of smoothened signaling pathway (ortholog); FOUND IN cell surface (ortholog); external side of plasma membrane (ortholog); extracellular space (ortholog) | NW_004955413 | 28339212 | 28461626 | Chinchilla | 9 | old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 11916365 | SCUBE1 | signal peptide, CUB domain and EGF like domain containing 1 | ENCODES a protein that exhibits calcium ion binding (inferred); identical protein binding (inferred); INVOLVED IN positive regulation of smoothened signaling pathway (ortholog); FOUND IN cell surface (inferred); external side of plasma membrane (inferred); extracellular region (inferred) | 22 | 24080438 | 24228401 | Bonobo | 14 | old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 12267133 | SCUBE1 | signal peptide, CUB domain and EGF like domain containing 1 | ENCODES a protein that exhibits calcium ion binding (inferred); identical protein binding (inferred); INVOLVED IN positive regulation of smoothened signaling pathway (ortholog); FOUND IN cell surface (inferred); external side of plasma membrane (inferred); extracellular region (inferred) | 10 | 22164430 | 22358981 | Dog | 14 | old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 12692393 | Scube1 | signal peptide, CUB domain and EGF like domain containing 1 | ENCODES a protein that exhibits calcium ion binding (inferred); identical protein binding (inferred); INVOLVED IN positive regulation of smoothened signaling pathway (ortholog); FOUND IN cell surface (inferred); external side of plasma membrane (inferred); extracellular region (inferred) | NW_004936718 | 1026770 | 1150465 | Squirrel | 16 | old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 13853669 | SCUBE1 | signal peptide, CUB domain and EGF like domain containing 1 | ENCODES a protein that exhibits calcium ion binding (inferred); identical protein binding (inferred); INVOLVED IN positive regulation of smoothened signaling pathway (ortholog); FOUND IN cell surface (inferred); external side of plasma membrane (inferred); extracellular region (inferred) | | | | Pig | 14 | old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 18726984 | SCUBE1 | signal peptide, CUB domain and EGF like domain containing 1 | ENCODES a protein that exhibits identical protein binding (ortholog); INVOLVED IN positive regulation of smoothened signaling pathway (ortholog); FOUND IN cell surface (ortholog); external side of plasma membrane (ortholog); extracellular space (ortholog) | | | | Green Monkey | 9 | old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 18919802 | Scube1 | signal peptide, CUB domain and EGF like domain containing 1 | ENCODES a protein that exhibits identical protein binding (ortholog); INVOLVED IN positive regulation of smoothened signaling pathway (ortholog); FOUND IN external side of plasma membrane (ortholog); plasma membrane (ortholog) | | | | Naked Mole-Rat | 14 | old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 20866144 | SCUBE1 | signal peptide, CUB domain and EGF like domain containing 1 | ENCODES a protein that exhibits calcium ion binding (inferred); identical protein binding (inferred); INVOLVED IN signal transduction (inferred); FOUND IN cell surface (inferred); external side of plasma membrane (inferred); extracellular region (inferred) | | | | Green Monkey | 10 | name | gene, protein-coding |
| 626117980 | Scube1 | signal peptide, CUB domain and EGF like domain containing 1 | ENCODES a protein that exhibits identical protein binding (ortholog); INVOLVED IN positive regulation of smoothened signaling pathway (ortholog); FOUND IN cell surface (ortholog); external side of plasma membrane (ortholog); extracellular space (ortholog) | | | | Black Rat | 9 | old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 1352842 | SCUBE2 | signal peptide, CUB domain and EGF like domain containing 2 | Predicted to enable calcium ion binding activity; hedgehog family protein binding activity; and lipid binding activity. Predicted to be involved in signal transduction. Predicted to act upstream of or within several processes, including chondrocyte differentiation involved in endochondral bone morph ogenesis; positive regulation of chondrocyte proliferation; and positive regulation of osteoblast differentiation. Predicted to be located in extracellular region. Predicted to be active in cell surface and extracellular space. [provided by Alliance of Genome Resources, Apr 2025] | 11 | 9019476 | 9091599 | Human | 92 | old_gene_name , name , old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 1563998 | Scube2 | signal peptide, CUB domain and EGF like domain containing 2 | ENCODES a protein that exhibits hedgehog family protein binding (ortholog); INVOLVED IN chondrocyte differentiation involved in endochondral bone morphogenesis (ortholog); positive regulation of chondrocyte proliferation (ortholog); positive regulation of ossification (ortholog); FOUND IN extracellu lar space (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; dimethylarsinic acid; endosulfan | 1 | 173264862 | 173341323 | Rat | 92 | old_gene_name , name | gene, protein-coding, VALIDATED [RefSeq] |
| 8773330 | Scube2 | signal peptide, CUB domain and EGF like domain containing 2 | ENCODES a protein that exhibits hedgehog family protein binding (ortholog); INVOLVED IN chondrocyte differentiation involved in endochondral bone morphogenesis (ortholog); positive regulation of chondrocyte proliferation (ortholog); positive regulation of ossification (ortholog); FOUND IN extracellu lar space (ortholog) | NW_004955414 | 24751134 | 24818338 | Chinchilla | 11 | old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 11680918 | SCUBE2 | signal peptide, CUB domain and EGF like domain containing 2 | ENCODES a protein that exhibits hedgehog family protein binding (ortholog); INVOLVED IN chondrocyte differentiation involved in endochondral bone morphogenesis (ortholog); positive regulation of chondrocyte proliferation (ortholog); positive regulation of ossification (ortholog); FOUND IN cell surfa ce (inferred); extracellular region (inferred); extracellular space (inferred) | 11 | 9146533 | 9219816 | Bonobo | 18 | old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 12052103 | SCUBE2 | signal peptide, CUB domain and EGF like domain containing 2 | ENCODES a protein that exhibits hedgehog family protein binding (ortholog); INVOLVED IN chondrocyte differentiation involved in endochondral bone morphogenesis (ortholog); positive regulation of chondrocyte proliferation (ortholog); positive regulation of ossification (ortholog); FOUND IN extracellu lar space (ortholog); INTERACTS WITH bisphenol A | 21 | 32370361 | 32435608 | Dog | 20 | old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 12694707 | Scube2 | signal peptide, CUB domain and EGF like domain containing 2 | ENCODES a protein that exhibits hedgehog family protein binding (ortholog); INVOLVED IN chondrocyte differentiation involved in endochondral bone morphogenesis (ortholog); positive regulation of chondrocyte proliferation (ortholog); positive regulation of ossification (ortholog); FOUND IN cell surfa ce (inferred); extracellular region (inferred); extracellular space (inferred) | NW_004936528 | 8981079 | 9060033 | Squirrel | 19 | old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 14173161 | SCUBE2 | signal peptide, CUB domain and EGF like domain containing 2 | ENCODES a protein that exhibits hedgehog family protein binding (ortholog); INVOLVED IN chondrocyte differentiation involved in endochondral bone morphogenesis (ortholog); positive regulation of chondrocyte proliferation (ortholog); positive regulation of ossification (ortholog); FOUND IN extracellu lar space (ortholog); INTERACTS WITH deoxynivalenol | | | | Pig | 14 | old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 18624596 | SCUBE2 | signal peptide, CUB domain and EGF like domain containing 2 | ENCODES a protein that exhibits hedgehog family protein binding (ortholog); INVOLVED IN chondrocyte differentiation involved in endochondral bone morphogenesis (ortholog); positive regulation of chondrocyte proliferation (ortholog); positive regulation of ossification (ortholog); FOUND IN cell surfa ce (inferred); extracellular region (inferred); extracellular space (inferred) | | | | Green Monkey | 17 | old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 18902664 | Scube2 | signal peptide, CUB domain and EGF like domain containing 2 | ENCODES a protein that exhibits hedgehog family protein binding (ortholog); INVOLVED IN chondrocyte differentiation involved in endochondral bone morphogenesis (ortholog); positive regulation of chondrocyte proliferation (ortholog); positive regulation of ossification (ortholog); FOUND IN cell surfa ce (inferred); extracellular region (inferred); extracellular space (inferred) | | | | Naked Mole-Rat | 19 | old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 625990138 | Scube2 | signal peptide, CUB domain and EGF like domain containing 2 | ENCODES a protein that exhibits hedgehog family protein binding (ortholog); INVOLVED IN chondrocyte differentiation involved in endochondral bone morphogenesis (ortholog); positive regulation of chondrocyte proliferation (ortholog); positive regulation of ossification (ortholog); FOUND IN extracellu lar space (ortholog) | | | | Black Rat | 11 | old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 1304880 | Scube3 | signal peptide, CUB domain and EGF like domain containing 3 | ENCODES a protein that exhibits BMP binding (ortholog); BMP receptor binding (ortholog); identical protein binding (ortholog); INVOLVED IN positive regulation of BMP signaling pathway (ortholog); positive regulation of osteoblast differentiation (ortholog); positive regulation of smoothened signalin g pathway (ortholog); ASSOCIATED WITH Desbuquois dysplasia (ortholog); Dwarfism (ortholog); genetic disease (ortholog); FOUND IN cell surface (ortholog); plasma membrane (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 3,3',4,4',5-pentachlorobiphenyl; 3,7-dihydropurine-6-thione | 20 | 6200891 | 6232848 | Rat | 94 | old_gene_name , name | gene, protein-coding, VALIDATED [RefSeq] |
| 1312575 | SCUBE3 | signal peptide, CUB domain and EGF like domain containing 3 | This gene encodes a member of the signal peptide, complement subcomponents C1r/C1s, Uegf, bone morphogenetic protein-1 and epidermal growth factor-like domain containing protein family. Overexpression of this gene in human embryonic kidney cells results in secre tion of a glycosylated form of the protein that forms oligomers and tethers to the cell surface. This gene is upregulated in lung cancer tumor tissue compared to healthy tissue and is associated with loss of the epithelial marker E-cadherin and with increased expression of vimentin, a mesenchymal marker. In addition, the protein encoded by this gene is a transforming growth factor beta receptor ligand, and when secreted by cancer cells, it can be cleaved in vitro to release the N-terminal epidermal growth factor-like repeat domain and the C-terminal complement subcomponents C1r/C1s domain. Both the full length protein and C-terminal fragment can bind to the transforming growth factor beta type II receptor to promote the epithelial-mesenchymal transition and tumor angiogenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014] | 6 | 35213956 | 35253079 | Human | 203 | old_gene_name , name , description , old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 8940499 | Scube3 | signal peptide, CUB domain and EGF like domain containing 3 | ENCODES a protein that exhibits BMP binding (ortholog); BMP receptor binding (ortholog); identical protein binding (ortholog); INVOLVED IN positive regulation of BMP signaling pathway (ortholog); positive regulation of osteoblast differentiation (ortholog); positive regulation of smoothened signalin g pathway (ortholog); ASSOCIATED WITH Desbuquois dysplasia (ortholog); Dwarfism (ortholog); genetic disease (ortholog); FOUND IN cell surface (ortholog); plasma membrane (ortholog) | NW_004955437 | 3178985 | 3213772 | Chinchilla | 18 | old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 12009395 | SCUBE3 | signal peptide, CUB domain and EGF like domain containing 3 | ENCODES a protein that exhibits BMP binding (inferred); BMP receptor binding (inferred); calcium ion binding (inferred); INVOLVED IN positive regulation of smoothened signaling pathway (ortholog); ASSOCIATED WITH Desbuquois dysplasia (ortholog); Dwarfism (ortholog); genetic disease (ortholog); FOUND IN cell surface (inferred); extracellular region (inferred); extracellular space (inferred) | 6 | 34776605 | 34815808 | Bonobo | 25 | old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 12310654 | SCUBE3 | signal peptide, CUB domain and EGF like domain containing 3 | ENCODES a protein that exhibits BMP binding (inferred); BMP receptor binding (inferred); calcium ion binding (inferred); INVOLVED IN positive regulation of smoothened signaling pathway (ortholog); ASSOCIATED WITH Desbuquois dysplasia (ortholog); Dwarfism (ortholog); genetic disease (ortholog); FOUND IN cell surface (inferred); extracellular region (inferred); plasma membrane (inferred) | 12 | 4383649 | 4420844 | Dog | 26 | old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 12659601 | Scube3 | signal peptide, CUB domain and EGF like domain containing 3 | ENCODES a protein that exhibits BMP binding (inferred); BMP receptor binding (inferred); calcium ion binding (inferred); INVOLVED IN positive regulation of smoothened signaling pathway (ortholog); ASSOCIATED WITH Desbuquois dysplasia (ortholog); Dwarfism (ortholog); genetic disease (ortholog); FOUND IN cell surface (inferred); extracellular region (inferred); extracellular space (inferred) | NW_004936476 | 23962956 | 23987629 | Squirrel | 25 | old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 13904518 | SCUBE3 | signal peptide, CUB domain and EGF like domain containing 3 | ENCODES a protein that exhibits BMP binding (inferred); BMP receptor binding (inferred); calcium ion binding (inferred); INVOLVED IN positive regulation of smoothened signaling pathway (ortholog); ASSOCIATED WITH Desbuquois dysplasia (ortholog); Dwarfism (ortholog); genetic disease (ortholog); FOUND IN cell surface (inferred); extracellular region (inferred); plasma membrane (inferred) | | | | Pig | 26 | old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 18597983 | SCUBE3 | signal peptide, CUB domain and EGF like domain containing 3 | ENCODES a protein that exhibits BMP binding (inferred); BMP receptor binding (inferred); calcium ion binding (inferred); INVOLVED IN positive regulation of smoothened signaling pathway (ortholog); ASSOCIATED WITH Desbuquois dysplasia (ortholog); Dwarfism (ortholog); genetic disease (ortholog); FOUND IN cell surface (inferred); extracellular region (inferred); extracellular space (inferred) | | | | Green Monkey | 25 | old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 18935114 | Scube3 | signal peptide, CUB domain and EGF like domain containing 3 | ENCODES a protein that exhibits BMP binding (ortholog); BMP receptor binding (ortholog); identical protein binding (ortholog); INVOLVED IN positive regulation of BMP signaling pathway (ortholog); positive regulation of smoothened signaling pathway (ortholog); ASSOCIATED WITH Desbuquois dysplasia (or tholog); Dwarfism (ortholog); genetic disease (ortholog); FOUND IN plasma membrane (ortholog) | | | | Naked Mole-Rat | 23 | old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 626036570 | Scube3 | signal peptide, CUB domain and EGF like domain containing 3 | ENCODES a protein that exhibits BMP binding (ortholog); BMP receptor binding (ortholog); identical protein binding (ortholog); INVOLVED IN positive regulation of BMP signaling pathway (ortholog); positive regulation of osteoblast differentiation (ortholog); positive regulation of smoothened signalin g pathway (ortholog); ASSOCIATED WITH Desbuquois dysplasia (ortholog); Dwarfism (ortholog); genetic disease (ortholog); FOUND IN cell surface (ortholog); plasma membrane (ortholog) | | | | Black Rat | 17 | old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 1359357 | Eogt | EGF domain specific O-linked N-acetylglucosamine transferase | ENCODES a protein that exhibits protein O-acetylglucosaminyltransferase activity (ortholog); INVOLVED IN protein O-linked glycosylation (ortholog); ASSOCIATED WITH Adams-Oliver syndrome (ortholog); Adams-Oliver Syndrome 4 (ortholog); Desbuquois dysplasia (ortholog); FOUND IN endoplasmic reticulum lu men (inferred); INTERACTS WITH (+)-schisandrin B; 2,3,7,8-tetrachlorodibenzodioxine; acrylamide | 4 | 131275587 | 131313243 | Rat | 91 | old_gene_name , name | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1550671 | Eogt | EGF domain specific O-linked N-acetylglucosamine transferase | Enables protein O-acetylglucosaminyltransferase activity. Involved in protein O-linked glycosylation. Predicted to be active in endoplasmic reticulum lumen. Is expressed in several structures, including blood vessel; central nervous system; limb; lung; and tail unsegmented mesenchyme. Human ortholog (s) of this gene implicated in Adams-Oliver syndrome. Orthologous to human EOGT (EGF domain specific O-linked N-acetylglucosamine transferase). [provided by Alliance of Genome Resources, Apr 2025] | 6 | 97086977 | 97128445 | Mouse | 94 | old_gene_name , name , description | gene, protein-coding, VALIDATED [RefSeq] |
| 1602633 | EOGT | EGF domain specific O-linked N-acetylglucosamine transferase | This gene encodes an enzyme that acts in the lumen of the endoplasmic reticulum to catalyze the transfer of N-acetylglucosamine to serine or threonine residues of extracellular-targeted proteins. This enzyme modifies proteins containing eukaryotic growth factor (EGF pan>)-like domains, including the Notch receptor, thereby regulating developmental signalling. Mutations in this gene have been observed in individuals with Adams-Oliver syndrome 4. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2015] | 3 | 68975225 | 69013684 | Human | 219 | old_gene_name , name , description | gene, protein-coding, REVIEWED [RefSeq] |
| 9041808 | Eogt | EGF domain specific O-linked N-acetylglucosamine transferase | ENCODES a protein that exhibits protein O-acetylglucosaminyltransferase activity (ortholog); INVOLVED IN protein O-linked glycosylation (ortholog); ASSOCIATED WITH Adams-Oliver syndrome (ortholog); Adams-Oliver Syndrome 4 (ortholog); Desbuquois dysplasia (ortholog) | NW_004955421 | 18845626 | 18879008 | Chinchilla | 8 | old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 11691591 | EOGT | EGF domain specific O-linked N-acetylglucosamine transferase | ENCODES a protein that exhibits glycosyltransferase activity (inferred); protein O-acetylglucosaminyltransferase activity (inferred); transferase activity (inferred); INVOLVED IN protein O-linked glycosylation (inferred); ASSOCIATED WITH Adams-Oliver syndrome (ortholog); Adams-Oliver Syndrome 4 (ort holog); Desbuquois dysplasia (ortholog); FOUND IN endoplasmic reticulum lumen (inferred) | 3 | 68910100 | 68950816 | Bonobo | 15 | old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 12111876 | EOGT | EGF domain specific O-linked N-acetylglucosamine transferase | ENCODES a protein that exhibits protein O-acetylglucosaminyltransferase activity (ortholog); INVOLVED IN protein O-linked glycosylation (ortholog); ASSOCIATED WITH Adams-Oliver syndrome (ortholog); Adams-Oliver Syndrome 4 (ortholog); Desbuquois dysplasia (ortholog); FOUND IN endoplasmic reticulum lu men (inferred) | 20 | 22722142 | 22757188 | Dog | 18 | old_gene_name , name | gene, protein-coding, PROVISIONAL [RefSeq] |
| 12543285 | Eogt | EGF domain specific O-linked N-acetylglucosamine transferase | ENCODES a protein that exhibits glycosyltransferase activity (inferred); protein O-acetylglucosaminyltransferase activity (inferred); INVOLVED IN protein O-linked glycosylation (inferred); ASSOCIATED WITH Adams-Oliver syndrome (ortholog); Adams-Oliver Syndrome 4 (ortholog); Desbuquois dysplasia (ort holog); FOUND IN endoplasmic reticulum lumen (inferred) | NW_004936603 | 1608173 | 1638052 | Squirrel | 12 | old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 14281166 | EOGT | EGF domain specific O-linked N-acetylglucosamine transferase | ENCODES a protein that exhibits glycosyltransferase activity (inferred); protein O-acetylglucosaminyltransferase activity (inferred); transferase activity (inferred); INVOLVED IN protein O-linked glycosylation (inferred); ASSOCIATED WITH Adams-Oliver syndrome (ortholog); Adams-Oliver Syndrome 4 (ort holog); Desbuquois dysplasia (ortholog) | | | | Pig | 14 | old_gene_name , name | gene, protein-coding, PROVISIONAL [RefSeq] |
| 18459890 | EOGT | EGF domain specific O-linked N-acetylglucosamine transferase | ENCODES a protein that exhibits glycosyltransferase activity (inferred); protein O-acetylglucosaminyltransferase activity (inferred); transferase activity (inferred); INVOLVED IN protein O-linked glycosylation (inferred); ASSOCIATED WITH Adams-Oliver syndrome (ortholog); Adams-Oliver Syndrome 4 (ort holog); Desbuquois dysplasia (ortholog); FOUND IN endoplasmic reticulum lumen (inferred) | | | | Green Monkey | 15 | old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 18922312 | Eogt | EGF domain specific O-linked N-acetylglucosamine transferase | ENCODES a protein that exhibits glycosyltransferase activity (inferred); protein O-acetylglucosaminyltransferase activity (inferred); transferase activity (inferred); INVOLVED IN protein O-linked glycosylation (ortholog); ASSOCIATED WITH Adams-Oliver syndrome (ortholog); Adams-Oliver Syndrome 4 (ort holog); Desbuquois dysplasia (ortholog); FOUND IN endoplasmic reticulum lumen (inferred) | | | | Naked Mole-Rat | 14 | old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 626101090 | Eogt | EGF domain specific O-linked N-acetylglucosamine transferase | ENCODES a protein that exhibits protein O-acetylglucosaminyltransferase activity (ortholog); INVOLVED IN protein O-linked glycosylation (ortholog); ASSOCIATED WITH Adams-Oliver syndrome (ortholog); Adams-Oliver Syndrome 4 (ortholog); Desbuquois dysplasia (ortholog) | | | | Black Rat | 8 | old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 14133745 | LOC100152993 | signal peptide, CUB and EGF-like domain-containing protein 3 | | | | | Pig | | old_gene_name , name | gene, protein-coding |
| 14165726 | LOC110256043 | signal peptide, CUB and EGF-like domain-containing protein 3 | ENCODES a protein that exhibits peptidase inhibitor activity (inferred); FOUND IN extracellular region (inferred) | | | | Pig | 3 | name | gene, protein-coding, MODEL [RefSeq] |
| 151670681 | LOC124905945 | signal peptide, CUB and EGF-like domain-containing protein 3 | | | | | Human | | name | gene, protein-coding, MODEL [RefSeq] |
| 151671651 | LOC124905946 | signal peptide, CUB and EGF-like domain-containing protein 3 | | | | | Human | | name | gene, protein-coding, MODEL [RefSeq] |
| 40913983 | LOC119880998 | von Willebrand factor C and EGF domain-containing protein-like | | | | | Dog | | name | gene, protein-coding, MODEL [RefSeq] |
| 621642 | Tie1 | tyrosine kinase with immunoglobulin-like and EGF-like domains 1 | ENCODES a protein that exhibits ATP binding (inferred); kinase activity (inferred); nucleotide binding (inferred); INVOLVED IN vasculogenesis; aortic valve morphogenesis (ortholog); blood vessel development (ortholog); ASSOCIATED WITH Lymphatic Malformation 11 (ortholog); FOUND IN plasma membrane (o rtholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; ammonium chloride; atrazine | 5 | 137285408 | 137305047 | Rat | 124 | name | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1346429 | TIE1 | tyrosine kinase with immunoglobulin like and EGF like domains 1 | This gene encodes a member of the tyrosine protein kinase family. The encoded protein plays a critical role in angiogenesis and blood vessel stability by inhibiting angiopoietin 1 signaling through the endothelial receptor tyrosine kinase Tie2. Ectodomain cleavage of the encoded protein relieves inh ibition of Tie2 and is mediated by multiple factors including vascular endothelial growth factor. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011] | 1 | 43300982 | 43323108 | Human | 131 | old_gene_name , name | gene, protein-coding, REVIEWED [RefSeq] |
| 1551713 | Tie1 | tyrosine kinase with immunoglobulin-like and EGF-like domains 1 | Predicted to enable transmembrane receptor protein tyrosine kinase activity. Involved in circulatory system development; response to retinoic acid; and tissue remodeling. Acts upstream of or within several processes, including negative regulation of angiogenesis; plasma membrane fusion; and vasculat ure development. Located in plasma membrane. Is expressed in several structures, including cardiovascular system; central nervous system; extraembryonic component; genitourinary system; and immune system. Human ortholog(s) of this gene implicated in hereditary lymphedema. Orthologous to human TIE1 (tyrosine kinase with immunoglobulin like and EGF like domains 1). [provided by Alliance of Genome Resources, Jul 2025] | 4 | 118328388 | 118347046 | Mouse | 177 | name , description | gene, protein-coding, VALIDATED [RefSeq] |
| 8922352 | Tie1 | tyrosine kinase with immunoglobulin like and EGF like domains 1 | INVOLVED IN aortic valve morphogenesis (ortholog); blood vessel development (ortholog); branching involved in lymph vessel morphogenesis (ortholog); ASSOCIATED WITH Lymphatic Malformation 11 (ortholog); FOUND IN plasma membrane (ortholog) | NW_004955537 | 2894913 | 2914284 | Chinchilla | 20 | old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 11685119 | TIE1 | tyrosine kinase with immunoglobulin like and EGF like domains 1 | ENCODES a protein that exhibits ATP binding (inferred); kinase activity (inferred); nucleotide binding (inferred); INVOLVED IN blood vessel development (ortholog); in utero embryonic development (ortholog); lymphatic endothelial cell differentiation (ortholog); ASSOCIATED WITH Lymphatic Malformation 11 (ortholog); FOUND IN plasma membrane (inferred); receptor complex (inferred) | 1 | 42602333 | 42624471 | Bonobo | 39 | name | gene, protein-coding, MODEL [RefSeq] |
| 12130863 | TIE1 | tyrosine kinase with immunoglobulin like and EGF like domains 1 | ENCODES a protein that exhibits ATP binding (inferred); kinase activity (inferred); nucleotide binding (inferred); INVOLVED IN blood vessel development (ortholog); in utero embryonic development (ortholog); lymphatic endothelial cell differentiation (ortholog); ASSOCIATED WITH Lymphatic Malformation 11 (ortholog); FOUND IN plasma membrane (inferred) | 15 | 16838267 | 16857004 | Dog | 39 | name | gene, protein-coding, MODEL [RefSeq] |
| 12574509 | Tie1 | tyrosine kinase with immunoglobulin like and EGF like domains 1 | ENCODES a protein that exhibits ATP binding (inferred); kinase activity (inferred); nucleotide binding (inferred); INVOLVED IN blood vessel development (ortholog); in utero embryonic development (ortholog); lymphatic endothelial cell differentiation (ortholog); ASSOCIATED WITH Lymphatic Malformation 11 (ortholog); FOUND IN plasma membrane (inferred); receptor complex (inferred) | NW_004936474 | 24709424 | 24729246 | Squirrel | 40 | old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 14010950 | TIE1 | tyrosine kinase with immunoglobulin like and EGF like domains 1 | ENCODES a protein that exhibits ATP binding (inferred); kinase activity (inferred); nucleotide binding (inferred); INVOLVED IN blood vessel development (ortholog); in utero embryonic development (ortholog); lymphatic endothelial cell differentiation (ortholog); ASSOCIATED WITH Lymphatic Malformation 11 (ortholog); FOUND IN plasma membrane (inferred) | | | | Pig | 39 | name | gene, protein-coding, MODEL [RefSeq] |
| 18586332 | TIE1 | tyrosine kinase with immunoglobulin like and EGF like domains 1 | ENCODES a protein that exhibits ATP binding (inferred); kinase activity (inferred); nucleotide binding (inferred); INVOLVED IN blood vessel development (ortholog); in utero embryonic development (ortholog); lymphatic endothelial cell differentiation (ortholog); ASSOCIATED WITH Lymphatic Malformation 11 (ortholog); FOUND IN plasma membrane (inferred); receptor complex (inferred) | | | | Green Monkey | 39 | name | gene, protein-coding, MODEL [RefSeq] |
| 18929410 | Tie1 | tyrosine kinase with immunoglobulin like and EGF like domains 1 | ENCODES a protein that exhibits ATP binding (inferred); kinase activity (inferred); nucleotide binding (inferred); INVOLVED IN blood vessel development (ortholog); in utero embryonic development (ortholog); lymphatic endothelial cell differentiation (ortholog); ASSOCIATED WITH Lymphatic Malformation 11 (ortholog); FOUND IN plasma membrane (inferred); receptor complex (inferred) | | | | Naked Mole-Rat | 40 | name | gene, protein-coding, MODEL [RefSeq] |
| 625923515 | Tie1 | tyrosine kinase with immunoglobulin like and EGF like domains 1 | INVOLVED IN aortic valve morphogenesis (ortholog); blood vessel development (ortholog); branching involved in lymph vessel morphogenesis (ortholog); ASSOCIATED WITH Lymphatic Malformation 11 (ortholog); FOUND IN plasma membrane (ortholog) | | | | Black Rat | 20 | name | gene, protein-coding, MODEL [RefSeq] |
| 62005 | Tmeff1 | transmembrane protein with EGF-like and two follistatin-like domains 1 | ENCODES a protein that exhibits receptor ligand inhibitor activity (ortholog); INVOLVED IN host-mediated suppression of symbiont invasion (ortholog); FOUND IN plasma membrane (ortholog); INTERACTS WITH 2,2',4,4'-Tetrabromodiphenyl ether; 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzof uran | 5 | 67706269 | 67792022 | Rat | 94 | old_gene_name , name | gene, protein-coding, VALIDATED [RefSeq] |
| 62297 | Tmeff1 | transmembrane protein with EGF-like and two follistatin-like domains 1 | Predicted to enable receptor ligand inhibitor activity. Involved in host-mediated suppression of symbiont invasion. Predicted to be active in plasma membrane. Is expressed in several structures, including alimentary system; brain; ganglia; genitourinary system; and sensory organ. Orthologous to seve ral human genes including TMEFF1 (transmembrane protein with EGF like and two follistatin like domains 1). [provided by Alliance of Genome Resources, Apr 2025] | 4 | 48585064 | 48663136 | Mouse | 93 | old_gene_name , name , description | gene, protein-coding, VALIDATED [RefSeq] |
| 735335 | TMEFF1 | transmembrane protein with EGF like and two follistatin like domains 1 | Enables receptor ligand inhibitor activity. Involved in host-mediated suppression of symbiont invasion. Is active in plasma membrane. [provided by Alliance of Genome Resources, Jul 2025] | 9 | 100473149 | 100577636 | Human | 85 | old_gene_name , name | gene, protein-coding, VALIDATED [RefSeq] |
| 8946927 | Tmeff1 | transmembrane protein with EGF like and two follistatin like domains 1 | ENCODES a protein that exhibits receptor ligand inhibitor activity (ortholog); INVOLVED IN host-mediated suppression of symbiont invasion (ortholog); FOUND IN plasma membrane (ortholog) | NW_004955419 | 25189131 | 25283818 | Chinchilla | 5 | old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 11801628 | TMEFF1 | transmembrane protein with EGF like and two follistatin like domains 1 | ENCODES a protein that exhibits receptor ligand inhibitor activity (ortholog); INVOLVED IN host-mediated suppression of symbiont invasion (inferred); FOUND IN plasma membrane (ortholog) | 9 | 71681899 | 71788447 | Bonobo | 5 | old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 12298157 | TMEFF1 | transmembrane protein with EGF like and two follistatin like domains 1 | ENCODES a protein that exhibits receptor ligand inhibitor activity (inferred); INVOLVED IN host-mediated suppression of symbiont invasion (inferred); FOUND IN plasma membrane (inferred) | 11 | 57331085 | 57453023 | Dog | 8 | name | gene, protein-coding, MODEL [RefSeq] |
| 13884926 | TMEFF1 | transmembrane protein with EGF like and two follistatin like domains 1 | ENCODES a protein that exhibits receptor ligand inhibitor activity (inferred); INVOLVED IN host-mediated suppression of symbiont invasion (inferred); FOUND IN plasma membrane (inferred) | | | | Pig | 8 | name | gene, protein-coding, MODEL [RefSeq] |
| 18633154 | TMEFF1 | transmembrane protein with EGF like and two follistatin like domains 1 | ENCODES a protein that exhibits receptor ligand inhibitor activity (ortholog); INVOLVED IN host-mediated suppression of symbiont invasion (ortholog); FOUND IN plasma membrane (ortholog) | | | | Green Monkey | 5 | name | gene, protein-coding, MODEL [RefSeq] |
| 20866740 | TMEFF1 | transmembrane protein with EGF like and two follistatin like domains 1 | ENCODES a protein that exhibits receptor ligand inhibitor activity (inferred); INVOLVED IN host-mediated suppression of symbiont invasion (inferred); FOUND IN plasma membrane (inferred) | | | | Green Monkey | 6 | name | gene, protein-coding |
| 626024800 | Tmeff1 | transmembrane protein with EGF like and two follistatin like domains 1 | ENCODES a protein that exhibits receptor ligand inhibitor activity (ortholog); INVOLVED IN host-mediated suppression of symbiont invasion (ortholog); FOUND IN plasma membrane (ortholog) | | | | Black Rat | 5 | name | gene, protein-coding, MODEL [RefSeq] |
| 1308839 | Tmeff2 | transmembrane protein with EGF-like and two follistatin-like domains 2 | INVOLVED IN negative regulation of cell migration (ortholog); negative regulation of integrin biosynthetic process (ortholog); negative regulation of stress fiber assembly (ortholog); ASSOCIATED WITH Breast Neoplasms (ortholog); polycystic ovary syndrome (ortholog); prostate cancer (ortholog); FOUND IN membrane (inferred); INTERACTS WITH 1-naphthyl isothiocyanate; 6-propyl-2-thiouracil; amitrole | 9 | 57937873 | 58225372 | Rat | 124 | name | gene, protein-coding, VALIDATED [RefSeq] |
| 1318843 | TMEFF2 | transmembrane protein with EGF like and two follistatin like domains 2 | This gene encodes a member of the tomoregulin family of transmembrane proteins. This protein has been shown to function as both an oncogene and a tumor suppressor depending on the cellular context and may regulate prostate cancer cell invasion. Multiple soluble forms of this protein have been identi fied that arise from both an alternative splice variant and ectodomain shedding. Additionally, this gene has been found to be hypermethylated in multiple cancer types. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2015] | 2 | 191949046 | 192194933 | Human | 129 | old_gene_name , name | gene, protein-coding, REVIEWED [RefSeq] |
| 1318844 | Tmeff2 | transmembrane protein with EGF-like and two follistatin-like domains 2 | Predicted to be involved in cell differentiation. Predicted to act upstream of or within negative regulation of cell migration; negative regulation of cellular component organization; and wound healing, spreading of cells. Predicted to be located in membrane. Predicted to be active in extracellular region. Is expressed in several structures, including gut; nervous system; prostate gland; vibrissa; and white fat. Human ortholog(s) of this gene implicated in prostate cancer and urinary bladder cancer. Orthologous to human TMEFF2 (transmembrane protein with EGF like and two follistatin like domains 2). [provided by Alliance of Genome Resources, Jul 2025] | 1 | 50951946 | 51226429 | Mouse | 142 | name , description | gene, protein-coding, VALIDATED [RefSeq] |
| 8797210 | Tmeff2 | transmembrane protein with EGF like and two follistatin like domains 2 | INVOLVED IN negative regulation of cell migration (ortholog); negative regulation of integrin biosynthetic process (ortholog); negative regulation of stress fiber assembly (ortholog); ASSOCIATED WITH Breast Neoplasms (ortholog); polycystic ovary syndrome (ortholog); prostate cancer (ortholog) | NW_004955403 | 7122019 | 7353769 | Chinchilla | 14 | old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 11791908 | TMEFF2 | transmembrane protein with EGF like and two follistatin like domains 2 | INVOLVED IN negative regulation of cell migration (ortholog); negative regulation of integrin biosynthetic process (ortholog); negative regulation of stress fiber assembly (ortholog); ASSOCIATED WITH Breast Neoplasms (ortholog); polycystic ovary syndrome (ortholog); prostate cancer (ortholog); FOUND IN membrane (inferred) | 2B | 79242825 | 79489113 | Bonobo | 16 | name | gene, protein-coding, MODEL [RefSeq] |
| 12167914 | TMEFF2 | transmembrane protein with EGF like and two follistatin like domains 2 | INVOLVED IN negative regulation of cell migration (ortholog); negative regulation of integrin biosynthetic process (ortholog); negative regulation of stress fiber assembly (ortholog); ASSOCIATED WITH Breast Neoplasms (ortholog); polycystic ovary syndrome (ortholog); prostate cancer (ortholog); FOUND IN membrane (inferred) | 37 | 2414208 | 2635283 | Dog | 18 | name | gene, protein-coding, MODEL [RefSeq] |
| 12669072 | Tmeff2 | transmembrane protein with EGF like and two follistatin like domains 2 | INVOLVED IN negative regulation of cell migration (ortholog); negative regulation of integrin biosynthetic process (ortholog); negative regulation of stress fiber assembly (ortholog); ASSOCIATED WITH Breast Neoplasms (ortholog); polycystic ovary syndrome (ortholog); prostate cancer (ortholog); FOUND IN membrane (inferred) | NW_004936506 | 6113521 | 6375986 | Squirrel | 16 | old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 13888238 | TMEFF2 | transmembrane protein with EGF like and two follistatin like domains 2 | INVOLVED IN negative regulation of cell migration (ortholog); negative regulation of integrin biosynthetic process (ortholog); negative regulation of stress fiber assembly (ortholog); ASSOCIATED WITH Breast Neoplasms (ortholog); polycystic ovary syndrome (ortholog); prostate cancer (ortholog); FOUND IN membrane (inferred) | | | | Pig | 16 | name | gene, protein-coding, MODEL [RefSeq] |
| 18378239 | TMEFF2 | transmembrane protein with EGF like and two follistatin like domains 2 | INVOLVED IN negative regulation of cell migration (ortholog); negative regulation of integrin biosynthetic process (ortholog); negative regulation of stress fiber assembly (ortholog); ASSOCIATED WITH Breast Neoplasms (ortholog); polycystic ovary syndrome (ortholog); prostate cancer (ortholog); FOUND IN membrane (inferred) | | | | Green Monkey | 16 | name | gene, protein-coding, MODEL [RefSeq] |
| 18905301 | Tmeff2 | transmembrane protein with EGF like and two follistatin like domains 2 | INVOLVED IN negative regulation of cell migration (ortholog); negative regulation of integrin biosynthetic process (ortholog); negative regulation of stress fiber assembly (ortholog); ASSOCIATED WITH Breast Neoplasms (ortholog); polycystic ovary syndrome (ortholog); prostate cancer (ortholog); FOUND IN membrane (inferred) | | | | Naked Mole-Rat | 16 | name | gene, protein-coding, MODEL [RefSeq] |
| 625908456 | Tmeff2 | transmembrane protein with EGF like and two follistatin like domains 2 | INVOLVED IN negative regulation of cell migration (ortholog); negative regulation of integrin biosynthetic process (ortholog); negative regulation of stress fiber assembly (ortholog); ASSOCIATED WITH Breast Neoplasms (ortholog); polycystic ovary syndrome (ortholog); prostate cancer (ortholog) | | | | Black Rat | 14 | name | gene, protein-coding, MODEL [RefSeq] |
| 12192911 | EMR4 | EGF-like module containing, mucin-like, hormone receptor-like sequence 4 | ENCODES a protein that exhibits calcium ion binding (inferred); G protein-coupled receptor activity (inferred); transmembrane signaling receptor activity (inferred); INVOLVED IN cell surface receptor signaling pathway (inferred); G protein-coupled receptor signaling pathway (inferred); signal transd uction (inferred); FOUND IN cell surface (ortholog) | 20 | 53342233 | 53385263 | Dog | 14 | old_gene_name , name | gene, protein-coding, VALIDATED [RefSeq] |
| 14159902 | EMR4 | EGF-like module containing, mucin-like, hormone receptor-like sequence 4 | ENCODES a protein that exhibits calcium ion binding (inferred); G protein-coupled receptor activity (inferred); transmembrane signaling receptor activity (inferred); INVOLVED IN cell surface receptor signaling pathway (inferred); G protein-coupled receptor signaling pathway (inferred); signal transd uction (inferred); FOUND IN membrane (inferred); plasma membrane (inferred) | | | | Pig | 13 | old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 1350967 | SVEP1 | sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1 | Enables integrin binding activity. Involved in negative regulation of vasoconstriction and positive regulation of platelet activation. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Jul 2025] | 9 | 110365248 | 110579741 | Human | 134 | old_gene_name , name | gene, protein-coding, VALIDATED [RefSeq] |
| 1557866 | Svep1 | sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1 | Enables chromatin binding activity and integrin binding activity involved in cell-matrix adhesion. Involved in positive regulation of platelet activation. Acts upstream of or within several processes, including Tie signaling pathway; lymph circulation; and lymph vessel morphogenesis. Located in extr acellular space. Is expressed in several structures, including alimentary system; genitourinary system; hemolymphoid system; liver sinusoid; and respiratory system. Orthologous to human SVEP1 (sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1). [provided by Alliance of Genome Resources, Jul 2025] | 4 | 58042796 | 58206596 | Mouse | 168 | old_gene_name , name , description | gene, protein-coding, VALIDATED [RefSeq] |
| 1588987 | Svep1 | sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1 | ENCODES a protein that exhibits chromatin binding (ortholog); integrin binding (ortholog); integrin binding involved in cell-matrix adhesion (ortholog); INVOLVED IN epidermis development (ortholog); gene expression (ortholog); lymph circulation (ortholog); FOUND IN cytoplasm (ortholog); extracellula r region (ortholog); extracellular space (ortholog); INTERACTS WITH 1-naphthyl isothiocyanate; 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran | 5 | 77606523 | 77783292 | Rat | 146 | old_gene_name , name | gene, protein-coding, VALIDATED [RefSeq] |
| 8843964 | Svep1 | sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1 | ENCODES a protein that exhibits chromatin binding (ortholog); integrin binding (ortholog); integrin binding involved in cell-matrix adhesion (ortholog); INVOLVED IN epidermis development (ortholog); gene expression (ortholog); lymph circulation (ortholog); FOUND IN cytoplasm (ortholog); extracellula r region (ortholog); extracellular space (ortholog) | NW_004955419 | 16589811 | 16773425 | Chinchilla | 24 | old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 11856737 | SVEP1 | sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1 | ENCODES a protein that exhibits calcium ion binding (inferred); chromatin binding (inferred); integrin binding (inferred); INVOLVED IN epidermis development (ortholog); gene expression (ortholog); lymph circulation (ortholog); FOUND IN cytoplasm (inferred); extracellular region (inferred); extracell ular space (inferred) | 9 | 81521495 | 81727869 | Bonobo | 33 | old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 12387282 | SVEP1 | sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1 | ENCODES a protein that exhibits calcium ion binding (inferred); chromatin binding (inferred); integrin binding (inferred); INVOLVED IN epidermis development (ortholog); gene expression (ortholog); lymph circulation (ortholog); FOUND IN cytoplasm (inferred); extracellular region (inferred); extracell ular space (inferred) | 11 | 65312723 | 65494014 | Dog | 31 | old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 12663280 | Svep1 | sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1 | ENCODES a protein that exhibits calcium ion binding (inferred); chromatin binding (inferred); integrin binding (inferred); INVOLVED IN epidermis development (ortholog); gene expression (ortholog); lymph circulation (ortholog); FOUND IN cytoplasm (inferred); extracellular matrix (inferred); extracell ular region (inferred) | NW_004936559 | 2556207 | 2726670 | Squirrel | 33 | old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 14162452 | SVEP1 | sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1 | ENCODES a protein that exhibits calcium ion binding (inferred); chromatin binding (inferred); integrin binding (inferred); INVOLVED IN epidermis development (ortholog); gene expression (ortholog); lymph circulation (ortholog); FOUND IN cytoplasm (inferred); extracellular region (inferred); extracell ular space (inferred); INTERACTS WITH deoxynivalenol | | | | Pig | 38 | old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 18541937 | SVEP1 | sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1 | ENCODES a protein that exhibits calcium ion binding (inferred); chromatin binding (inferred); integrin binding (inferred); INVOLVED IN epidermis development (ortholog); gene expression (ortholog); lymph circulation (ortholog); FOUND IN cytoplasm (inferred); extracellular region (inferred); extracell ular space (inferred) | | | | Green Monkey | 33 | old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 18919528 | Svep1 | sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1 | ENCODES a protein that exhibits chromatin binding (ortholog); integrin binding (ortholog); integrin binding involved in cell-matrix adhesion (ortholog); INVOLVED IN epidermis development (ortholog); gene expression (ortholog); lymph circulation (ortholog); FOUND IN extracellular space (ortholog) | | | | Naked Mole-Rat | 32 | old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 626099157 | Svep1 | sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1 | ENCODES a protein that exhibits chromatin binding (ortholog); integrin binding (ortholog); integrin binding involved in cell-matrix adhesion (ortholog); INVOLVED IN epidermis development (ortholog); gene expression (ortholog); lymph circulation (ortholog); FOUND IN cytoplasm (ortholog); extracellula r region (ortholog); extracellular space (ortholog) | | | | Black Rat | 24 | old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 16565169 | AC020895.1 | egf-like module containing, mucin-like, hormone receptor-like 1 (EMR1) pseudogene | | | | | Human | | name | gene, unprocessed_pseudogene |
| 1619279 | Egfbp2 | epidermal growth factor binding protein type B | The protein encoded by this gene belongs to the kallikrein family, which is a highly homologous group of serine proteases encoded by a cluster of related genes on chromosome 7. This gene has been shown to function as both a prorenin converting enzyme and as epidermal growth factor (EGF -weight:700;'>EGF)-binding protein involved in the maturation of EGF (PMIDs: 1918045, 3322387, 9685728). This gene is thought to be distinct from Klk1b26 gene (GeneID:16618), with which it shares 98% identity (PMID:1959648, 9685728), however, it is not clear if both genes are present in all strains of mice. Blast analyses suggest that this gene is missing from the current reference (GRCm38, based on C57BL/6J genome) and alternate Celera (based on mixed strain genomes) assemblies. Therefore, the RefSeq for this locus was based on sequence from the ICR strain, which has been reported in literature (PMID:1959648) to contain both genes. [provided by RefSeq, Aug 2012] | | | | Mouse | 27 | symbol , old_gene_name , PhenoGen , description , old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 1619280 | Klk1b22 | kallikrein 1-related peptidase b22 | This gene encodes the beta subunit of the 7S nerve growth factor (NGF) complex that is essential for the differentiation and survival of distinct populations of neurons in both the central and the peripheral nervous systems. The encoded preproprotein undergoes proteolytic processing to generate a fu nctional, mature peptide. This gene is located in a cluster of several related kallikrein genes on chromosome 7. [provided by RefSeq, Feb 2016] | 7 | 43762097 | 43766346 | Mouse | 34 | old_gene_name , old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 1619278 | Klk1b9 | kallikrein 1-related peptidase b9 | This gene encodes a member of the kallikrein subfamily of serine proteases that are involved in diverse physiological functions such as skin desquamation, tooth enamel formation, seminal liquefaction, synaptic neural plasticity and brain function. The encoded preproprotein undergoes proteolytic clea vage of the activation peptide to generate the functional enzyme. This gene is located in a cluster of several related kallikrein genes on chromosome 7. [provided by RefSeq, Feb 2016] | 7 | 43625485 | 43629800 | Mouse | 22 | old_gene_name , old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 1352005 | ADGRG1 | adhesion G protein-coupled receptor G1 | This gene encodes a member of the G protein-coupled receptor family and regulates brain cortical patterning. The encoded protein binds specifically to transglutaminase 2, a component of tissue and tumor stroma implicated as an inhibitor of tumor progression. Mutations in this gene are associated wit h a brain malformation known as bilateral frontoparietal polymicrogyria. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014] | 16 | 57619738 | 57665567 | Human | 392 | old_gene_name | gene, protein-coding, REVIEWED [RefSeq] |
| 1313843 | ADGRG3 | adhesion G protein-coupled receptor G3 | Predicted to enable G protein-coupled receptor activity. Involved in G protein-coupled receptor signaling pathway and regulation of cell migration. Located in plasma membrane. [provided by Alliance of Genome Resources, Jul 2025] | 16 | 57665629 | 57689378 | Human | 86 | old_gene_name | gene, protein-coding, VALIDATED [RefSeq] |
| 13961258 | EGFR | epidermal growth factor receptor | ENCODES a protein that exhibits calmodulin binding (ortholog); epidermal growth factor binding (ortholog); epidermal growth factor receptor activity (ortholog); INVOLVED IN astrocyte activation (ortholog); cell morphogenesis (ortholog); cell surface receptor signaling pathway (ortholog); PARTICIPATE S IN altered epidermal growth factor/neuregulin signaling pathway; cetuximab pharmacodynamics pathway; E-cadherin signaling pathway; ASSOCIATED WITH acute kidney failure (ortholog); Acute Lung Injury (ortholog); adenocarcinoma (ortholog); FOUND IN apical plasma membrane (ortholog); basolateral plasma membrane (ortholog); cell surface (ortholog); INTERACTS WITH hyaluronic acid; hydrogen peroxide; oleanolic acid | | | | Pig | 533 | symbol , old_gene_name | gene, protein-coding, PROVISIONAL [RefSeq] |
| 733023 | Klk1b26 | kallikrein 1-related petidase b26 | This gene encodes a member of the kallikrein subfamily of the peptidase S1 family of serine proteases. The kallikrein genes are present in a large gene cluster on chromosome 7. The encoded preproprotein is proteolytically processed to generate a mature protein product. Expression of this gene in the submandibular gland is sexually dimorphic likely due to both transcriptional and post-transcriptional regulation. This gene is thought to be distinct from the Egfbp2 gene (Gene ID: 13647), with which it shares 98% identity (PMIDs: 1959648, 9685728), however, it is not clear if both genes are present in all strains of mice. [provided by RefSeq, Sep 2015] | 7 | 43662102 | 43666393 | Mouse | 35 | old_gene_name , description , old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 1313718 | Adgre5 | adhesion G protein-coupled receptor E5 | Predicted to enable G protein-coupled receptor activity and chondroitin sulfate binding activity. Acts upstream of or within positive regulation of synapse assembly. Located in external side of plasma membrane. Is expressed in several structures, including central nervous system; eye; genitourinary system; gut; and immune system. Human ortholog(s) of this gene implicated in vibratory urticaria. Orthologous to several human genes including ADGRE5 (adhesion G protein-coupled receptor E5). [provided by Alliance of Genome Resources, Jul 2025] | 8 | 84449874 | 84467812 | Mouse | 142 | old_gene_name | gene, protein-coding, VALIDATED [RefSeq] |
| 732484 | Adgrl4 | adhesion G protein-coupled receptor L4 | Predicted to enable G protein-coupled receptor activity. Predicted to be involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway and protein-containing complex assembly. Predicted to be located in cytoplasmic vesicle. Predicted to be active in plasma membrane. Is expres sed in brain; cardiovascular system; lung; metanephros; and skeletal muscle. Orthologous to human ADGRL4 (adhesion G protein-coupled receptor L4). [provided by Alliance of Genome Resources, Apr 2025] | 3 | 151143519 | 151250718 | Mouse | 118 | old_gene_name | gene, protein-coding, VALIDATED [RefSeq] |
| 1309143 | Dlk2 | delta like non-canonical Notch ligand 2 | ENCODES a protein that exhibits identical protein binding (ortholog); INVOLVED IN negative regulation of Notch signaling pathway (ortholog); regulation of fat cell differentiation (ortholog); FOUND IN membrane (inferred); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 3,7-dihydropurine-6-thione; 6-propyl-2-thiouracil | 9 | 22174667 | 22179149 | Rat | 77 | old_gene_name , old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 1319320 | DLK2 | delta like non-canonical Notch ligand 2 | Predicted to enable Notch binding activity. Involved in negative regulation of Notch signaling pathway. Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025] | 6 | 43450352 | 43456632 | Human | 75 | old_gene_name , old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 1319321 | Dlk2 | delta like non-canonical Notch ligand 2 | Enables identical protein binding activity. Involved in regulation of fat cell differentiation. Acts upstream of or within negative regulation of Notch signaling pathway. Predicted to be located in membrane. Is expressed in several structures, including alimentary system; brain; limb mesenchyme; met anephros; and musculoskeletal system. Orthologous to human DLK2 (delta like non-canonical Notch ligand 2). [provided by Alliance of Genome Resources, Jul 2025] | 17 | 46608342 | 46614197 | Mouse | 80 | old_gene_name , old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 13875903 | DLK2 | delta like non-canonical Notch ligand 2 | ENCODES a protein that exhibits calcium ion binding (inferred); identical protein binding (inferred); INVOLVED IN negative regulation of Notch signaling pathway (ortholog); FOUND IN membrane (inferred) | | | | Pig | 9 | old_gene_name , old_gene_symbol | gene, protein-coding, PROVISIONAL [RefSeq] |
| 732154 | ZFP36L1 | ZFP36 like 1 zinc finger CCCH-type | This gene is a member of the TIS11 family of early response genes, which are induced by various agonists such as the phorbol ester TPA and the polypeptide mitogen EGF. This gene is well conserved across species and has a promoter that contains motifs seen in oth er early-response genes. The encoded protein contains a distinguishing putative zinc finger domain with a repeating cys-his motif. This putative nuclear transcription factor most likely functions in regulating the response to growth factors. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011] | 14 | 68787655 | 68796243 | Human | 285 | old_gene_name , description | gene, protein-coding, REVIEWED [RefSeq] |
| 1318953 | ZFP36L2 | ZFP36 like 2 zinc finger CCCH-type | This gene is a member of the TIS11 family of early response genes. Family members are induced by various agonists such as the phorbol ester TPA and the polypeptide mitogen EGF. The encoded protein contains a distinguishing putative zinc finger domain with a repe ating cys-his motif. This putative nuclear transcription factor most likely functions in regulating the response to growth factors. [provided by RefSeq, Jul 2008] | 2 | 43222402 | 43226606 | Human | 232 | old_gene_name , description | gene, protein-coding, REVIEWED [RefSeq] |
| 1342649 | ADGRE1 | adhesion G protein-coupled receptor E1 | This gene encodes a protein that has a domain resembling seven transmembrane G protein-coupled hormone receptors (7TM receptors) at its C-terminus. The N-terminus of the encoded protein has six EGF-like modules, separated from the transmembrane segments by a ser ine/threonine-rich domain, a feature reminiscent of mucin-like, single-span, integral membrane glycoproteins with adhesive properties. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012] | 19 | 6887579 | 6940450 | Human | 199 | old_gene_name , description | gene, protein-coding, REVIEWED [RefSeq] |
| 1359214 | Adgre1 | adhesion G protein-coupled receptor E1 | ENCODES a protein that exhibits calcium ion binding (inferred); G protein-coupled receptor activity (inferred); transmembrane signaling receptor activity (inferred); INVOLVED IN cellular response to transforming growth factor beta stimulus; cellular response to tumor necrosis factor; ASSOCIATED WITH Experimental Liver Cirrhosis (ortholog); FOUND IN cell periphery (ortholog); external side of plasma membrane (ortholog); plasma membrane (ortholog); INTERACTS WITH 1-naphthyl isothiocyanate; 17beta-estradiol; 17beta-estradiol 3-benzoate | 9 | 2329398 | 2484959 | Rat | 197 | old_gene_name | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1345702 | ADGRE2 | adhesion G protein-coupled receptor E2 | This gene encodes a member of the class B seven-span transmembrane (TM7) subfamily of G-protein coupled receptors. These proteins are characterized by an extended extracellular region with a variable number of N-terminal epidermal growth factor-like domains coupled to a TM7 domain via a mucin-like s pacer domain. The encoded protein is expressed mainly in myeloid cells where it promotes cell-cell adhesion through interaction with chondroitin sulfate chains. This gene is situated in a cluster of related genes on chromosome 19. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2012] | 19 | 14724171 | 14778560 | Human | 94 | old_gene_name | gene, protein-coding, REVIEWED [RefSeq] |
| 12196567 | ADGRE2 | adhesion G protein-coupled receptor E2 | ENCODES a protein that exhibits chondroitin sulfate binding (ortholog); INVOLVED IN cell adhesion (ortholog); cell migration (ortholog); granulocyte chemotaxis (ortholog); ASSOCIATED WITH dermatographia (ortholog); vibratory urticaria (ortholog); FOUND IN leading edge membrane (ortholog) | 20 | 47929357 | 47968525 | Dog | 25 | old_gene_name | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1606765 | ADGRE3 | adhesion G protein-coupled receptor E3 | This gene encodes a member of the class B seven-span transmembrane (TM7) receptor family expressed predominantly by cells of the immune system. Family members are characterized by an extended extracellular region with a variable number of N-terminal epidermal growth factor (EGF 700;'>EGF)-like domains coupled to a TM7 domain via a mucin-like spacer domain. This gene is closely linked to the gene encoding egf-like molecule containing mucin-like hormone receptor 2 on chromosome 19. This protein may play a role in myeloid-myeloid interactions during immune and inflammatory responses. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2014] | 19 | 14600117 | 14674844 | Human | 34 | old_gene_name , description | gene, protein-coding, REVIEWED [RefSeq] |
| 12710056 | LOC101974337 | lysosomal thioesterase PPT2 | ENCODES a protein that exhibits calcium ion binding (inferred); fatty acyl-CoA hydrolase activity (inferred); hydrolase activity (inferred); INVOLVED IN macromolecule depalmitoylation (inferred); ASSOCIATED WITH neuronal ceroid lipofuscinosis (ortholog); FOUND IN cell surface (inferred); extracellul ar region (inferred); lysosome (inferred) | NW_004936727 | 1438593 | 1447728 | Squirrel | 19 | old_gene_name , old_gene_symbol | gene, protein-coding, MODEL [RefSeq] |
| 62009 | Zfp36l1 | zinc finger protein 36, C3H type-like 1 | ENCODES a protein that exhibits mRNA 3'-UTR AU-rich region binding; mRNA binding; 14-3-3 protein binding (ortholog); INVOLVED IN mRNA catabolic process; nuclear-transcribed mRNA catabolic process, deadenylation-independent decay; positive regulation of nuclear-transcribed mRNA catabolic process, dea denylation-dependent decay; ASSOCIATED WITH COVID-19 (ortholog); FOUND IN cytosol; cytoplasm (ortholog); nucleus (ortholog); INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 3-chloropropane-1,2-diol | 6 | 104663396 | 104669815 | Rat | 311 | old_gene_name | gene, protein-coding, PROVISIONAL [RefSeq] |
| 12218293 | DLK2 | delta like non-canonical Notch ligand 2 | ENCODES a protein that exhibits calcium ion binding (inferred); identical protein binding (inferred); INVOLVED IN negative regulation of Notch signaling pathway (ortholog); FOUND IN membrane (inferred) | 12 | 11919718 | 11924663 | Dog | 12 | old_gene_name , old_gene_symbol | gene, protein-coding, MODEL [RefSeq] |
| 732170 | FAT2 | FAT atypical cadherin 2 | This gene is the second identified human homolog of the Drosophila fat gene, which encodes a tumor suppressor essential for controlling cell proliferation during Drosophila development. The gene product is a member of the cadherin superfamily, a group of integral membrane proteins characterized by t he presence of cadherin-type repeats. In addition to containing 34 tandem cadherin-type repeats, the gene product has two epidermal growth factor (EGF)-like repeats and one laminin G domain. This protein most likely functions as a cell adhesion molecule, controlling cell proliferation and playing an important role in cerebellum development. [provided by RefSeq, Jul 2008] | 5 | 151504092 | 151594819 | Human | 110 | old_gene_name , description , old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 12016321 | LOC100975124 | multiple epidermal growth factor-like domains protein 6 | | 1 | 2155295 | 2283034 | Bonobo | 1 | old_gene_name , old_gene_symbol | gene, protein-coding, MODEL [RefSeq] |
| 18666836 | LOC103225737 | uncharacterized LOC103225737 | | | | | Green Monkey | 1 | old_gene_name , old_gene_symbol | gene, protein-coding, MODEL [RefSeq] |
| 731744 | LRP4 | LDL receptor related protein 4 | This gene encodes a member of the low-density lipoprotein receptor-related protein family. The encoded protein may be a regulator of Wnt signaling. Mutations in this gene are associated with Cenani-Lenz syndrome. [provided by RefSeq, May 2010] | 11 | 46856717 | 46918550 | Human | 417 | old_gene_name , old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 733848 | SLIT1 | slit guidance ligand 1 | Enables Roundabout binding activity. Involved in axon extension involved in axon guidance; motor neuron axon guidance; and negative chemotaxis. Predicted to be located in extracellular region. Predicted to be active in extracellular space. [provided by Alliance of Genome Resources, Jul 2025] | 10 | 96998038 | 97185959 | Human | 155 | old_gene_name , old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 733245 | SLIT3 | slit guidance ligand 3 | The protein encoded by this gene is secreted, likely interacting with roundabout homolog receptors to effect cell migration. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2012] | 5 | 168661740 | 169301139 | Human | 191 | old_gene_name , old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 1557020 | Itgbl1 | integrin, beta-like 1 | Predicted to enable integrin binding activity. Predicted to be involved in several processes, including cell adhesion mediated by integrin; cell-matrix adhesion; and integrin-mediated signaling pathway. Predicted to be located in extracellular region. Predicted to be part of integrin complex. Predic ted to be active in cell surface and focal adhesion. Is expressed in axial skeleton; brain; heart ventricle; meninges; and vibrissa. Orthologous to human ITGBL1 (integrin subunit beta like 1). [provided by Alliance of Genome Resources, Apr 2025] | 14 | 123897331 | 124215173 | Mouse | 91 | old_gene_name | gene, protein-coding, VALIDATED [RefSeq] |
| 1642918 | PEAR1 | platelet endothelial aggregation receptor 1 | PEAR1 is a platelet receptor that signals upon the formation of platelet-platelet contacts independent of platelet activation and secondary to platelet aggregation (Nanda et al., 2005 [PubMed 15851471]).[supplied by OMIM, Mar 2008] | 1 | 156893718 | 156916429 | Human | 92 | old_gene_name , old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 12435247 | PEAR1 | platelet endothelial aggregation receptor 1 | ENCODES a protein that exhibits signaling receptor activity (inferred); INVOLVED IN recognition of apoptotic cell (ortholog); FOUND IN lamellipodium (inferred); phagocytic cup (inferred); plasma membrane (inferred) | 7 | 41110925 | 41130532 | Dog | 12 | old_gene_name , old_gene_symbol | gene, protein-coding, MODEL [RefSeq] |
| 621136 | Adgrl4 | adhesion G protein-coupled receptor L4 | ENCODES a protein that exhibits calcium ion binding (inferred); G protein-coupled receptor activity (inferred); transmembrane signaling receptor activity (inferred); INVOLVED IN protein-containing complex assembly; ASSOCIATED WITH glioblastoma; hypertrophic cardiomyopathy (ortholog); Left Ventricula r Hypertrophy (ortholog); FOUND IN cytoplasmic vesicle; plasma membrane; INTERACTS WITH 17alpha-ethynylestradiol; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine | 2 | 243014927 | 243117226 | Rat | 100 | old_gene_name | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1347532 | ADGRL4 | adhesion G protein-coupled receptor L4 | Predicted to enable G protein-coupled receptor activity. Predicted to be involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway. Predicted to be located in cytoplasmic vesicle. Predicted to be active in plasma membrane. Biomarker of glioblastoma and hypertrophic cardio myopathy. [provided by Alliance of Genome Resources, Jul 2025] | 1 | 78889764 | 79006730 | Human | 105 | old_gene_name | gene, protein-coding, VALIDATED [RefSeq] |
| 620656 | Fat2 | FAT atypical cadherin 2 | ENCODES a protein that exhibits calcium ion binding (inferred); INVOLVED IN homophilic cell-cell adhesion; cell-substrate adhesion (ortholog); epithelial cell migration (ortholog); ASSOCIATED WITH esophagus squamous cell carcinoma (ortholog); spastic ataxia (ortholog); spinocerebellar ataxia 45 (ort holog); FOUND IN adherens junction (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; acrylamide; alpha-Zearalanol | 10 | 39864765 | 39957027 | Rat | 99 | old_gene_name , old_gene_symbol | gene, protein-coding, PROVISIONAL [RefSeq] |
| 69307 | Slit1 | slit guidance ligand 1 | ENCODES a protein that exhibits heparan sulfate proteoglycan binding; Roundabout binding (ortholog); INVOLVED IN negative regulation of axon extension involved in axon guidance; spinal cord development; axon extension involved in axon guidance (ortholog); ASSOCIATED WITH Brain Injuries; Monomelic Am yotrophy (ortholog); Spinal Cord Injuries (ortholog); FOUND IN extracellular space; INTERACTS WITH 17alpha-ethynylestradiol; 17beta-estradiol; 17beta-estradiol 3-benzoate | 1 | 250358917 | 250507476 | Rat | 150 | old_gene_name , old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 69311 | Slit3 | slit guidance ligand 3 | ENCODES a protein that exhibits Roundabout binding (ortholog); INVOLVED IN spinal cord development; animal organ morphogenesis (ortholog); aortic valve morphogenesis (ortholog); ASSOCIATED WITH Brain Injuries; congenital diaphragmatic hernia; atrial fibrillation (ortholog); FOUND IN cell junction (o rtholog); extracellular space (ortholog); INTERACTS WITH 1-naphthyl isothiocyanate; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene | 10 | 20075929 | 20660704 | Rat | 193 | old_gene_name , old_gene_symbol | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1313808 | Pear1 | platelet endothelial aggregation receptor 1 | Enables signaling receptor activity. Involved in phosphatidylinositol 3-kinase/protein kinase B signal transduction; platelet aggregation; and positive regulation of platelet activation. Acts upstream of or within recognition of apoptotic cell. Located in phagocytic cup. Is active in plasma membrane . Is expressed in brain; dorsal root ganglion; embryo; heart; and spinal cord. Orthologous to human PEAR1 (platelet endothelial aggregation receptor 1). [provided by Alliance of Genome Resources, Jul 2025] | 3 | 87656404 | 87676262 | Mouse | 97 | old_gene_name , old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 1309412 | Creld1 | CRELD disulfide isomerase 1 | ENCODES a protein that exhibits calcium ion binding (inferred); isomerase activity (inferred); protein disulfide isomerase activity (inferred); ASSOCIATED WITH Atrioventricular Septal Defect 2 (ortholog); Congenital Heart Defects, Multiple Types, 4 (ortholog); congenital heart disease (ortholog); FO UND IN glutamatergic synapse (ortholog); synapse (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4,6-trinitrotoluene; 2,4-dinitrotoluene | 4 | 148187510 | 148197120 | Rat | 95 | old_gene_name | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1319745 | CRELD1 | CRELD disulfide isomerase 1 | This gene encodes a member of a subfamily of epidermal growth factor-related proteins. The encoded protein is characterized by a cysteine-rich with epidermal growth factor-like domain. This protein may function as a cell adhesion molecule. Mutations in this gene are the cause of atrioventricular sep tal defect. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Apr 2010] | 3 | 9933834 | 9945406 | Human | 240 | old_gene_name | gene, protein-coding, REVIEWED [RefSeq] |
| 8744909 | Creld1 | CRELD disulfide isomerase 1 | ASSOCIATED WITH Atrioventricular Septal Defect 2 (ortholog); Congenital Heart Defects, Multiple Types, 4 (ortholog); congenital heart disease (ortholog); FOUND IN glutamatergic synapse (ortholog); synapse (ortholog) | NW_004955561 | 1423229 | 1430679 | Chinchilla | 15 | old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 11688247 | CRELD1 | CRELD disulfide isomerase 1 | ASSOCIATED WITH Atrioventricular Septal Defect 2 (ortholog); Congenital Heart Defects, Multiple Types, 4 (ortholog); congenital heart disease (ortholog); FOUND IN glutamatergic synapse (ortholog); synapse (ortholog) | 3 | 9878265 | 9889826 | Bonobo | 15 | old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 12542843 | Creld1 | CRELD disulfide isomerase 1 | ENCODES a protein that exhibits calcium ion binding (inferred); isomerase activity (inferred); protein disulfide isomerase activity (inferred); ASSOCIATED WITH Atrioventricular Septal Defect 2 (ortholog); Congenital Heart Defects, Multiple Types, 4 (ortholog); congenital heart disease (ortholog); FO UND IN glutamatergic synapse (inferred); membrane (inferred); synapse (inferred) | NW_004936602 | 3258029 | 3267231 | Squirrel | 19 | old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 18416208 | CRELD1 | CRELD disulfide isomerase 1 | ENCODES a protein that exhibits calcium ion binding (inferred); isomerase activity (inferred); protein disulfide isomerase activity (inferred); ASSOCIATED WITH Atrioventricular Septal Defect 2 (ortholog); Congenital Heart Defects, Multiple Types, 4 (ortholog); congenital heart disease (ortholog); FO UND IN glutamatergic synapse (inferred); membrane (inferred); synapse (inferred) | | | | Green Monkey | 19 | old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 18913491 | Creld1 | CRELD disulfide isomerase 1 | ENCODES a protein that exhibits calcium ion binding (inferred); isomerase activity (inferred); protein disulfide isomerase activity (inferred); ASSOCIATED WITH Atrioventricular Septal Defect 2 (ortholog); Congenital Heart Defects, Multiple Types, 4 (ortholog); congenital heart disease (ortholog); FO UND IN glutamatergic synapse (ortholog); synapse (ortholog) | | | | Naked Mole-Rat | 19 | old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 626024849 | Creld1 | CRELD disulfide isomerase 1 | ASSOCIATED WITH Atrioventricular Septal Defect 2 (ortholog); Congenital Heart Defects, Multiple Types, 4 (ortholog); congenital heart disease (ortholog); FOUND IN glutamatergic synapse (ortholog); synapse (ortholog) | | | | Black Rat | 15 | old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 1310614 | Creld2 | CRELD disulfide isomerase 2 | ENCODES a protein that exhibits calcium ion binding (inferred); isomerase activity (inferred); protein disulfide isomerase activity (inferred); FOUND IN endoplasmic reticulum (ortholog); extracellular space (ortholog); Golgi apparatus (ortholog); INTERACTS WITH (+)-schisandrin B; 17beta-estradiol; 2 ,3,7,8-tetrachlorodibenzodioxine | 7 | 121788754 | 121796230 | Rat | 152 | old_gene_name | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1603954 | CRELD2 | CRELD disulfide isomerase 2 | Predicted to enable calcium ion binding activity and protein disulfide isomerase activity. Predicted to be located in Golgi apparatus; endoplasmic reticulum; and extracellular space. [provided by Alliance of Genome Resources, Jul 2025] | 22 | 49918634 | 49927537 | Human | 149 | old_gene_name | gene, protein-coding, VALIDATED [RefSeq] |
| 8995934 | Creld2 | CRELD disulfide isomerase 2 | FOUND IN endoplasmic reticulum (ortholog); extracellular space (ortholog); Golgi apparatus (ortholog) | NW_004955413 | 33039931 | 33046622 | Chinchilla | 6 | old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 11898067 | CRELD2 | CRELD disulfide isomerase 2 | ENCODES a protein that exhibits calcium ion binding (inferred); isomerase activity (inferred); protein disulfide isomerase activity (inferred); FOUND IN endoplasmic reticulum (inferred); extracellular space (inferred); Golgi apparatus (inferred) | 22 | 30139539 | 30152462 | Bonobo | 10 | old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 12666824 | Creld2 | CRELD disulfide isomerase 2 | ENCODES a protein that exhibits calcium ion binding (inferred); isomerase activity (inferred); protein disulfide isomerase activity (inferred); FOUND IN endoplasmic reticulum (inferred); extracellular space (inferred); Golgi apparatus (inferred) | NW_004936629 | 835802 | 844009 | Squirrel | 9 | old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 18448495 | CRELD2 | CRELD disulfide isomerase 2 | ENCODES a protein that exhibits calcium ion binding (inferred); isomerase activity (inferred); protein disulfide isomerase activity (inferred); FOUND IN endoplasmic reticulum (inferred); extracellular space (inferred); Golgi apparatus (inferred) | | | | Green Monkey | 10 | old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 18906911 | Creld2 | CRELD disulfide isomerase 2 | ENCODES a protein that exhibits calcium ion binding (inferred); isomerase activity (inferred); protein disulfide isomerase activity (inferred); FOUND IN endoplasmic reticulum (ortholog); extracellular space (ortholog); Golgi apparatus (ortholog) | | | | Naked Mole-Rat | 9 | old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 626088457 | Creld2 | CRELD disulfide isomerase 2 | FOUND IN endoplasmic reticulum (ortholog); extracellular space (ortholog); Golgi apparatus (ortholog) | | | | Black Rat | 6 | old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 1316134 | Kctd11 | potassium channel tetramerisation domain containing 11 | Predicted to enable identical protein binding activity. Acts upstream of or within several processes, including negative regulation of neuroblast proliferation; negative regulation of smoothened signaling pathway; and positive regulation of neuron differentiation. Located in cytoplasm. Is expressed in several structures, including 1st branchial arch; central nervous system; ectoplacental cone; primitive streak; and sensory organ. Orthologous to human KCTD11 (potassium channel tetramerization domain containing 11). [provided by Alliance of Genome Resources, Jul 2025] | 11 | 69769090 | 69771811 | Mouse | 76 | old_gene_name | gene, protein-coding, VALIDATED [RefSeq] |
| 1603556 | CLEC14A | C-type lectin domain containing 14A | This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response. This fam ily member plays a role in cell-cell adhesion and angiogenesis. It functions in filopodia formation, cell migration and tube formation. Due to its presence at higher levels in tumor endothelium than in normal tissue endothelium, it is considered to be a candidate for tumor vascular targeting. [provided by RefSeq, Jan 2012] | 14 | 38254000 | 38256093 | Human | 91 | old_gene_name , old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 1348863 | ITGBL1 | integrin subunit beta like 1 | This gene encodes a beta integrin-related protein that is a member of the EGF-like protein family. The encoded protein contains integrin-like cysteine-rich repeats. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2012] | 13 | 101452675 | 101720856 | Human | 93 | old_gene_name , description | gene, protein-coding, REVIEWED [RefSeq] |
| 1316133 | KCTD11 | potassium channel tetramerization domain containing 11 | Enables identical protein binding activity. Predicted to be involved in positive regulation of neuron differentiation. Predicted to act upstream of or within negative regulation of neuroblast proliferation; negative regulation of smoothened signaling pathway; and nervous system development. Predicte d to be located in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025] | 17 | 7352162 | 7354944 | Human | 75 | old_gene_name | gene, protein-coding, VALIDATED [RefSeq] |
| 18604497 | LOC103221291 | uncharacterized LOC103221291 | | | | | Green Monkey | | old_gene_name | gene, ncrna, MODEL [RefSeq] |
| 2594 | Fbln5 | fibulin 5 | ENCODES a protein that exhibits integrin binding (ortholog); protein homodimerization activity (ortholog); INVOLVED IN regulation of cell growth; elastic fiber assembly (ortholog); extracellular matrix organization (ortholog); ASSOCIATED WITH adult respiratory distress syndrome (ortholog); age relat ed macular degeneration (ortholog); age related macular degeneration 1 (ortholog); FOUND IN extracellular space; elastic fiber (ortholog); extracellular matrix (ortholog); INTERACTS WITH 17alpha-ethynylestradiol; 17beta-estradiol; 2,2',5,5'-tetrachlorobiphenyl | 6 | 126664100 | 126742847 | Rat | 220 | old_gene_name | gene, protein-coding, PROVISIONAL [RefSeq] |
| 7747752 | Cdhr17 | cadherin related family member 17 | ENCODES a protein that exhibits calcium ion binding (inferred); INVOLVED IN cell adhesion (inferred); homophilic cell-cell adhesion (inferred); FOUND IN membrane (inferred); plasma membrane (inferred) | 4 | 19382943 | 19480347 | Rat | 7 | old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 18422846 | LOC103247530 | uncharacterized LOC103247530 | | | | | Green Monkey | | old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 1342531 | TEK | TEK receptor tyrosine kinase | This gene encodes a receptor that belongs to the protein tyrosine kinase Tie2 family. The encoded protein possesses a unique extracellular region that contains two immunoglobulin-like domains, three epidermal growth factor (EGF)-like domains and three fibronecti n type III repeats. The ligand angiopoietin-1 binds to this receptor and mediates a signaling pathway that functions in embryonic vascular development. Mutations in this gene are associated with inherited venous malformations of the skin and mucous membranes. Alternative splicing results in multiple transcript variants. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Feb 2014] | 9 | 27109225 | 27230174 | Human | 377 | old_gene_name , description | gene, protein-coding, REVIEWED [RefSeq] |
| 1552464 | Tek | TEK receptor tyrosine kinase | Enables protein tyrosine kinase activity and signaling receptor activity. Involved in several processes, including circulatory system development; negative regulation of endothelial cell apoptotic process; and response to retinoic acid. Acts upstream of or within several processes, including positiv e regulation of macromolecule metabolic process; positive regulation of protein import into nucleus; and regulation of non-canonical NF-kappaB signal transduction. Located in perinuclear region of cytoplasm. Is expressed in several structures, including cardiovascular system; central nervous system; extraembryonic component; genitourinary system; and immune system. Human ortholog(s) of this gene implicated in arteriovenous malformation; multiple cutaneous and mucosal venous malformations; and renal Wilms' tumor. Orthologous to human TEK (TEK receptor tyrosine kinase). [provided by Alliance of Genome Resources, Jul 2025] | 4 | 94627322 | 94763213 | Mouse | 368 | old_gene_name | gene, protein-coding, VALIDATED [RefSeq] |
| 9017016 | Itgbl1 | integrin subunit beta like 1 | | NW_004955404 | 9331407 | 9545711 | Chinchilla | | old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 1604498 | NPNT | nephronectin | Predicted to enable integrin binding activity. Predicted to be involved in several processes, including cell-cell adhesion mediated by integrin; positive regulation of ERK1 and ERK2 cascade; and positive regulation of alkaline phosphatase activity. Predicted to act upstream of or within positive reg ulation of transforming growth factor beta receptor signaling pathway. Located in collagen-containing extracellular matrix and extracellular exosome. [provided by Alliance of Genome Resources, Apr 2025] | 4 | 105895471 | 105971671 | Human | 139 | old_gene_name , old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 1614982 | Npnt | nephronectin | Enables integrin binding activity. Involved in several processes, including cell-cell adhesion mediated by integrin; pilomotor reflex; and positive regulation of metabolic process. Acts upstream of or within several processes, including branching involved in ureteric bud morphogenesis; positive regu lation of cell-substrate adhesion; and positive regulation of transforming growth factor beta receptor signaling pathway. Located in several cellular components, including basement membrane; collagen-containing extracellular matrix; and smooth muscle contractile fiber. Is expressed in several structures, including alimentary system; brain; genitourinary system; respiratory system; and sensory organ. Used to study bilateral renal aplasia. Orthologous to human NPNT (nephronectin). [provided by Alliance of Genome Resources, Apr 2025] | 3 | 132587506 | 132656052 | Mouse | 141 | old_gene_name | gene, protein-coding, VALIDATED [RefSeq] |
| 736145 | FBLN5 | fibulin 5 | The protein encoded by this gene is a secreted, extracellular matrix protein containing an Arg-Gly-Asp (RGD) motif and calcium-binding EGF-like domains. It promotes adhesion of endothelial cells through interaction of integrins and the RGD motif. It is prominent ly expressed in developing arteries but less so in adult vessels. However, its expression is reinduced in balloon-injured vessels and atherosclerotic lesions, notably in intimal vascular smooth muscle cells and endothelial cells. Therefore, the protein encoded by this gene may play a role in vascular development and remodeling. Defects in this gene are a cause of autosomal dominant cutis laxa, autosomal recessive cutis laxa type I (CL type I), and age-related macular degeneration type 3 (ARMD3). [provided by RefSeq, Jul 2008] | 14 | 91869411 | 91947694 | Human | 484 | old_gene_name , description | gene, protein-coding, REVIEWED [RefSeq] |
| 736146 | Fbln5 | fibulin 5 | Enables integrin binding activity. Involved in several processes, including elastic fiber assembly; intramembranous bone growth; and regulation of transcription by RNA polymerase II. Acts upstream of or within extracellular matrix organization. Located in extracellular space. Colocalizes with collag en-containing extracellular matrix and elastic fiber. Is expressed in several structures, including alimentary system; central nervous system; embryo mesenchyme; heart; and skeleton. Used to study cutis laxa. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease; age related macular degeneration; autosomal dominant cutis laxa 2; autosomal recessive cutis laxa type IA; and cutis laxa. Orthologous to human FBLN5 (fibulin 5). [provided by Alliance of Genome Resources, Apr 2025] | 12 | 101712820 | 101785541 | Mouse | 240 | old_gene_name | gene, protein-coding, VALIDATED [RefSeq] |
| 1318352 | Efemp1 | epidermal growth factor-containing fibulin-like extracellular matrix protein 1 | Predicted to enable epidermal growth factor receptor activity and epidermal growth factor receptor binding activity. Predicted to be involved in several processes, including negative regulation of chondrocyte differentiation; peptidyl-tyrosine phosphorylation; and regulation of cell projection organ ization. Located in collagen-containing extracellular matrix and extracellular space. Is expressed in several structures, including alimentary system; brain; embryo mesenchyme; male reproductive gland or organ; and skeleton. Used to study Doyne honeycomb retinal dystrophy. Human ortholog(s) of this gene implicated in Doyne honeycomb retinal dystrophy and cutis laxa. Orthologous to human EFEMP1 (EGF containing fibulin extracellular matrix protein 1). [provided by Alliance of Genome Resources, Apr 2025] | 11 | 28803154 | 28876743 | Mouse | 309 | old_gene_name , description | gene, protein-coding, VALIDATED [RefSeq] |
| 1551771 | Efemp2 | epidermal growth factor-containing fibulin-like extracellular matrix protein 2 | Predicted to enable heparin binding activity and protein homodimerization activity. Involved in several processes, including elastic fiber assembly; negative regulation of vascular associated smooth muscle cell proliferation; and vasculature development. Acts upstream of or within artery development . Located in basement membrane; elastic fiber; and microfibril. Is expressed in several structures, including central nervous system; genitourinary system; gut; immune system; and respiratory system. Used to study aortic aneurysm and cutis laxa. Human ortholog(s) of this gene implicated in aortic aneurysm; arterial tortuosity syndrome; autosomal recessive cutis laxa type IB; endometrial cancer; and osteosarcoma. Orthologous to human EFEMP2 (EGF containing fibulin extracellular matrix protein 2). [provided by Alliance of Genome Resources, Jul 2025] | 19 | 5523974 | 5532548 | Mouse | 231 | old_gene_name , description | gene, protein-coding, VALIDATED [RefSeq] |
| 8976858 | Adgrl4 | adhesion G protein-coupled receptor L4 | INVOLVED IN protein-containing complex assembly (ortholog); ASSOCIATED WITH glioblastoma (ortholog); hypertrophic cardiomyopathy (ortholog); Left Ventricular Hypertrophy (ortholog); FOUND IN cytoplasmic vesicle (ortholog); plasma membrane (ortholog) | NW_004955423 | 14395712 | 14487803 | Chinchilla | 8 | old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 11982824 | ADGRL4 | adhesion G protein-coupled receptor L4 | ENCODES a protein that exhibits calcium ion binding (inferred); G protein-coupled receptor activity (inferred); transmembrane signaling receptor activity (inferred); INVOLVED IN protein-containing complex assembly (ortholog); ASSOCIATED WITH glioblastoma (ortholog); hypertrophic cardiomyopathy (orth olog); Left Ventricular Hypertrophy (ortholog); FOUND IN cytoplasmic vesicle (ortholog) | 1 | 78099504 | 78216060 | Bonobo | 22 | old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 12372431 | ADGRL4 | adhesion G protein-coupled receptor L4 | ENCODES a protein that exhibits calcium ion binding (inferred); G protein-coupled receptor activity (inferred); transmembrane signaling receptor activity (inferred); INVOLVED IN protein-containing complex assembly (ortholog); ASSOCIATED WITH glioblastoma (ortholog); hypertrophic cardiomyopathy (orth olog); Left Ventricular Hypertrophy (ortholog); FOUND IN cytoplasmic vesicle (ortholog) | 6 | 68078481 | 68189422 | Dog | 21 | old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 12524382 | Adgrl4 | adhesion G protein-coupled receptor L4 | ENCODES a protein that exhibits calcium ion binding (inferred); G protein-coupled receptor activity (inferred); transmembrane signaling receptor activity (inferred); INVOLVED IN protein-containing complex assembly (ortholog); ASSOCIATED WITH glioblastoma (ortholog); hypertrophic cardiomyopathy (orth olog); Left Ventricular Hypertrophy (ortholog); FOUND IN cytoplasmic vesicle (ortholog) | NW_004936571 | 5587077 | 5691623 | Squirrel | 21 | old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 14085368 | ADGRL4 | adhesion G protein-coupled receptor L4 | ENCODES a protein that exhibits calcium ion binding (inferred); G protein-coupled receptor activity (inferred); transmembrane signaling receptor activity (inferred); INVOLVED IN protein-containing complex assembly (ortholog); ASSOCIATED WITH glioblastoma (ortholog); hypertrophic cardiomyopathy (orth olog); Left Ventricular Hypertrophy (ortholog); FOUND IN cytoplasmic vesicle (ortholog) | | | | Pig | 17 | old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 18912632 | Adgrl4 | adhesion G protein-coupled receptor L4 | ENCODES a protein that exhibits calcium ion binding (inferred); G protein-coupled receptor activity (inferred); transmembrane signaling receptor activity (inferred); INVOLVED IN protein-containing complex assembly (ortholog); ASSOCIATED WITH glioblastoma (ortholog); hypertrophic cardiomyopathy (orth olog); Left Ventricular Hypertrophy (ortholog); FOUND IN cytoplasmic vesicle (ortholog) | | | | Naked Mole-Rat | 21 | old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 2431 | Cspg5 | chondroitin sulfate proteoglycan 5 | INVOLVED IN axon regeneration; cytoskeleton organization; glial cell projection elongation; FOUND IN GABA-ergic synapse (ortholog); glutamatergic synapse (ortholog); Golgi apparatus (ortholog); INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; acrylamide | 8 | 119098932 | 119113191 | Rat | 101 | old_gene_name | gene, protein-coding, VALIDATED [RefSeq] |
| 733098 | CSPG5 | chondroitin sulfate proteoglycan 5 | The protein encoded by this gene is a proteoglycan that may function as a neural growth and differentiation factor. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2011] | 3 | 47562238 | 47580240 | Human | 105 | old_gene_name | gene, protein-coding, REVIEWED [RefSeq] |
| 735589 | Cspg5 | chondroitin sulfate proteoglycan 5 | This gene encodes a chondroitin sulfate proteoglycan. The encoded protein has been termed a 'part-time' proteoglycan, as chondroitin sulfate chains appear to be attached to the protein in the developing but not the adult cerebellum and retina. It is thought that this protein plays roles in dendrite branching and synapse formation. [provided by RefSeq, Oct 2009] | 9 | 110072851 | 110091644 | Mouse | 114 | old_gene_name | gene, protein-coding, REVIEWED [RefSeq] |
| 18402442 | ADGRE2 | adhesion G protein-coupled receptor E2 | ENCODES a protein that exhibits calcium ion binding (inferred); chondroitin sulfate binding (inferred); G protein-coupled receptor activity (inferred); INVOLVED IN adenylate cyclase-activating G protein-coupled receptor signaling pathway (inferred); cell adhesion (inferred); cell migration (inferred ); ASSOCIATED WITH dermatographia (ortholog); vibratory urticaria (ortholog); FOUND IN leading edge membrane (inferred); membrane (inferred); plasma membrane (inferred) | | | | Green Monkey | 30 | old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 18737600 | ADGRE3 | adhesion G protein-coupled receptor E3 | ENCODES a protein that exhibits calcium ion binding (inferred); G protein-coupled receptor activity (inferred); transmembrane signaling receptor activity (inferred); INVOLVED IN adenylate cyclase-activating G protein-coupled receptor signaling pathway (inferred); cell surface receptor signaling path way (inferred); G protein-coupled receptor signaling pathway (inferred); FOUND IN membrane (inferred); plasma membrane (inferred) | | | | Green Monkey | 14 | old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 1359641 | Adgre4 | adhesion G protein-coupled receptor E4 | ENCODES a protein that exhibits calcium ion binding (inferred); G protein-coupled receptor activity (inferred); transmembrane signaling receptor activity (inferred); INVOLVED IN cell surface receptor signaling pathway (inferred); G protein-coupled receptor signaling pathway (inferred); signal transd uction (inferred); FOUND IN cell surface (ortholog); INTERACTS WITH 17beta-estradiol; 17beta-estradiol 3-benzoate; 2,3,7,8-tetrachlorodibenzodioxine | 9 | 10085258 | 10240346 | Rat | 76 | old_gene_name | gene, protein-coding, VALIDATED [RefSeq] |
| 1349105 | STAB2 | stabilin 2 | This gene encodes a large, transmembrane receptor protein which may function in angiogenesis, lymphocyte homing, cell adhesion, or receptor scavenging. The protein contains 7 fasciclin, 15 epidermal growth factor (EGF)-like, and 2 laminin-type EGF weight:700;'>EGF-like domains as well as a C-type lectin-like hyaluronan-binding Link module. The protein is primarily expressed on sinusoidal endothelial cells of liver, spleen, and lymph node. The receptor has been shown to bind and endocytose ligands such as hyaluronan, low density lipoprotein, Gram-positive and Gram-negative bacteria, and advanced glycosylation end products. Supporting its possible role as a scavenger receptor, the protein has been shown to cycle between the plasma membrane and lysosomes. [provided by RefSeq, Jul 2008] | 12 | 103587273 | 103766719 | Human | 104 | old_gene_name , description | gene, protein-coding, REVIEWED [RefSeq] |
| 8801941 | Adgre1 | adhesion G protein-coupled receptor E1 | INVOLVED IN cellular response to transforming growth factor beta stimulus (ortholog); cellular response to tumor necrosis factor (ortholog); ASSOCIATED WITH Experimental Liver Cirrhosis (ortholog); FOUND IN cell periphery (ortholog); external side of plasma membrane (ortholog); plasma membrane (orth olog) | NW_004955495 | 2601413 | 2674738 | Chinchilla | 6 | old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 11712691 | ADGRE1 | adhesion G protein-coupled receptor E1 | ENCODES a protein that exhibits calcium ion binding (inferred); G protein-coupled receptor activity (inferred); transmembrane signaling receptor activity (inferred); INVOLVED IN cellular response to transforming growth factor beta stimulus (ortholog); cellular response to tumor necrosis factor (orth olog); ASSOCIATED WITH Experimental Liver Cirrhosis (ortholog); FOUND IN cell periphery (ortholog); external side of plasma membrane (ortholog) | 19 | 5918097 | 5970069 | Bonobo | 21 | old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 12276233 | ADGRE1 | adhesion G protein-coupled receptor E1 | ENCODES a protein that exhibits calcium ion binding (inferred); G protein-coupled receptor activity (inferred); transmembrane signaling receptor activity (inferred); INVOLVED IN cellular response to transforming growth factor beta stimulus (ortholog); cellular response to tumor necrosis factor (orth olog); ASSOCIATED WITH Experimental Liver Cirrhosis (ortholog); FOUND IN cell periphery (ortholog); external side of plasma membrane (ortholog) | 20 | 53404096 | 53465267 | Dog | 20 | old_gene_name | gene, protein-coding, PROVISIONAL [RefSeq] |
| 12655134 | Adgre1 | adhesion G protein-coupled receptor E1 | ENCODES a protein that exhibits calcium ion binding (inferred); G protein-coupled receptor activity (inferred); transmembrane signaling receptor activity (inferred); INVOLVED IN cellular response to transforming growth factor beta stimulus (ortholog); cellular response to tumor necrosis factor (orth olog); ASSOCIATED WITH Experimental Liver Cirrhosis (ortholog); FOUND IN cell periphery (inferred); external side of plasma membrane (inferred); membrane (inferred) | NW_004936588 | 4127497 | 4169323 | Squirrel | 19 | old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 13928716 | ADGRE1 | adhesion G protein-coupled receptor E1 | ENCODES a protein that exhibits calcium ion binding (inferred); G protein-coupled receptor activity (inferred); transmembrane signaling receptor activity (inferred); INVOLVED IN cellular response to transforming growth factor beta stimulus (ortholog); cellular response to tumor necrosis factor (orth olog); ASSOCIATED WITH Experimental Liver Cirrhosis (ortholog); FOUND IN cell periphery (ortholog); external side of plasma membrane (ortholog) | | | | Pig | 18 | old_gene_name | gene, protein-coding, VALIDATED [RefSeq] |
| 18912081 | Adgre1 | adhesion G protein-coupled receptor E1 | ENCODES a protein that exhibits calcium ion binding (inferred); G protein-coupled receptor activity (inferred); transmembrane signaling receptor activity (inferred); INVOLVED IN cellular response to transforming growth factor beta stimulus (ortholog); cellular response to tumor necrosis factor (orth olog); ASSOCIATED WITH Experimental Liver Cirrhosis (ortholog); FOUND IN cell periphery (ortholog); external side of plasma membrane (ortholog) | | | | Naked Mole-Rat | 18 | old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 11949673 | ADGRE3 | adhesion G protein-coupled receptor E3 | ENCODES a protein that exhibits calcium ion binding (inferred); G protein-coupled receptor activity (inferred); transmembrane signaling receptor activity (inferred); INVOLVED IN adenylate cyclase-activating G protein-coupled receptor signaling pathway (inferred); cell surface receptor signaling path way (inferred); G protein-coupled receptor signaling pathway (inferred); FOUND IN membrane (inferred); plasma membrane (inferred); ruffle membrane (inferred) | 19 | 14163207 | 14225794 | Bonobo | 16 | old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 12060288 | ADGRE3 | adhesion G protein-coupled receptor E3 | ENCODES a protein that exhibits calcium ion binding (inferred); G protein-coupled receptor activity (inferred); transmembrane signaling receptor activity (inferred); INVOLVED IN cell adhesion (inferred); cell surface receptor signaling pathway (inferred); G protein-coupled receptor signaling pathway (inferred); FOUND IN membrane (inferred); plasma membrane (inferred) | 20 | 48021336 | 48060618 | Dog | 14 | old_gene_name | gene, protein-coding, PROVISIONAL [RefSeq] |
| 12683224 | Adgre3 | adhesion G protein-coupled receptor E3 | ENCODES a protein that exhibits calcium ion binding (inferred); G protein-coupled receptor activity (inferred); transmembrane signaling receptor activity (inferred); INVOLVED IN adenylate cyclase-activating G protein-coupled receptor signaling pathway (inferred); cell surface receptor signaling path way (inferred); G protein-coupled receptor signaling pathway (inferred); FOUND IN membrane (inferred); plasma membrane (inferred) | NW_004936659 | 3113865 | 3143135 | Squirrel | 13 | old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 14124930 | ADGRE3 | adhesion G protein-coupled receptor E3 | ENCODES a protein that exhibits calcium ion binding (inferred); G protein-coupled receptor activity (inferred); transmembrane signaling receptor activity (inferred); INVOLVED IN cell surface receptor signaling pathway (inferred); G protein-coupled receptor signaling pathway (inferred); inflammatory response (inferred); FOUND IN membrane (inferred); ruffle membrane (inferred) | | | | Pig | 14 | old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 11786721 | LOC100974936 | adhesion G protein-coupled receptor E2 | ENCODES a protein that exhibits calcium ion binding (inferred); chondroitin sulfate binding (inferred); G protein-coupled receptor activity (inferred); INVOLVED IN adenylate cyclase-activating G protein-coupled receptor signaling pathway (inferred); cell adhesion (inferred); cell migration (inferred ); ASSOCIATED WITH dermatographia (ortholog); vibratory urticaria (ortholog); FOUND IN leading edge membrane (inferred); membrane (inferred); plasma membrane (inferred) | 19 | 14259830 | 14331832 | Bonobo | 26 | old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 12558500 | LOC101968115 | adhesion G protein-coupled receptor E2 | | NW_004937019 | 205848 | 300657 | Squirrel | | old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 12178390 | LOC484898 | adhesion G protein-coupled receptor E2 | ENCODES a protein that exhibits calcium ion binding (inferred); G protein-coupled receptor activity (inferred); transmembrane signaling receptor activity (inferred); INVOLVED IN cell adhesion (inferred); cell surface receptor signaling pathway (inferred); G protein-coupled receptor signaling pathway (inferred); FOUND IN membrane (inferred); plasma membrane (inferred) | 20 | 47873908 | 47916365 | Dog | 9 | old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 5013873 | MSANTD3-TMEFF1 | MSANTD3-TMEFF1 readthrough | This locus represents naturally occurring read-through transcription from the neighboring MSANTD3 (Myb/SANT-like DNA-binding domain containing 3) and TMEFF1 (transmembrane protein with EGF-like and two follistatin-like domains 1) genes. The read-through transcri pt encodes a fusion protein that shares sequence identity with the products of each individual gene. [provided by RefSeq, Aug 2013] | 9 | 100441906 | 100577636 | Human | 18 | old_gene_name , description | gene, protein-coding, VALIDATED [RefSeq] |
| 18402103 | ADGRL4 | adhesion G protein-coupled receptor L4 | ENCODES a protein that exhibits calcium ion binding (inferred); G protein-coupled receptor activity (inferred); transmembrane signaling receptor activity (inferred); INVOLVED IN protein-containing complex assembly (ortholog); ASSOCIATED WITH glioblastoma (ortholog); hypertrophic cardiomyopathy (orth olog); Left Ventricular Hypertrophy (ortholog); FOUND IN cytoplasmic vesicle (ortholog) | | | | Green Monkey | 22 | old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 11823987 | LOC100967790 | putative adhesion G protein-coupled receptor E4P | ENCODES a protein that exhibits calcium ion binding (inferred); G protein-coupled receptor activity (inferred); transmembrane signaling receptor activity (inferred); INVOLVED IN adenylate cyclase-activating G protein-coupled receptor signaling pathway (inferred); cell surface receptor signaling path way (inferred); G protein-coupled receptor signaling pathway (inferred); FOUND IN membrane (inferred); plasma membrane (inferred) | 19 | 5982040 | 6026565 | Bonobo | 14 | old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 18923938 | LOC101710773 | myb/SANT-like DNA-binding domain-containing protein 3 | ENCODES a protein that exhibits DNA binding (inferred); INVOLVED IN host-mediated suppression of symbiont invasion (inferred); FOUND IN plasma membrane (inferred) | | | | Naked Mole-Rat | 4 | old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 12591896 | LOC101972861 | tomoregulin-1 | ENCODES a protein that exhibits receptor ligand inhibitor activity (inferred); INVOLVED IN host-mediated suppression of symbiont invasion (inferred); FOUND IN plasma membrane (inferred) | NW_004936524 | 8749721 | 8868219 | Squirrel | 6 | old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 18715068 | LOC103234345 | putative adhesion G protein-coupled receptor E4P | | | | | Green Monkey | | old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 1321166 | STAB1 | stabilin 1 | This gene encodes a large, transmembrane receptor protein which may function in angiogenesis, lymphocyte homing, cell adhesion, or receptor scavenging. The protein contains 7 fasciclin, 16 epidermal growth factor (EGF)-like, and 2 laminin-type EGF weight:700;'>EGF-like domains as well as a C-type lectin-like hyaluronan-binding Link module. The protein is primarily expressed on sinusoidal endothelial cells of liver, spleen, and lymph node. The receptor has been shown to endocytose ligands such as low density lipoprotein, Gram-positive and Gram-negative bacteria, and advanced glycosylation end products. Supporting its possible role as a scavenger receptor, the protein rapidly cycles between the plasma membrane and early endosomes. [provided by RefSeq, Jul 2008] | 3 | 52495338 | 52524495 | Human | 129 | old_gene_name , description | gene, protein-coding, REVIEWED [RefSeq] |
| 1321167 | Stab1 | stabilin 1 | Predicted to enable low-density lipoprotein particle binding activity; low-density lipoprotein particle receptor activity; and scavenger receptor activity. Predicted to be involved in cell-cell signaling; defense response to bacterium; and negative regulation of angiogenesis. Predicted to be located in cytoplasm and plasma membrane. Is expressed in several structures, including blood; cardiovascular system; early conceptus; genitourinary system; and retina nuclear layer. Orthologous to human STAB1 (stabilin 1). [provided by Alliance of Genome Resources, Jul 2025] | 14 | 30860974 | 30890616 | Mouse | 135 | old_gene_name | gene, protein-coding, VALIDATED [RefSeq] |
| 628822 | Stab2 | stabilin 2 | ENCODES a protein that exhibits hyaluronic acid binding; cargo receptor activity (ortholog); low-density lipoprotein particle binding (ortholog); INVOLVED IN endocytosis; defense response to bacterium (ortholog); defense response to Gram-positive bacterium (ortholog); ASSOCIATED WITH hepatocellular carcinoma (ortholog); Prostatic Neoplasms (ortholog); FOUND IN external side of plasma membrane; cytosol (ortholog); plasma membrane (ortholog); INTERACTS WITH (+)-schisandrin B; 1,2-dimethylhydrazine; 17beta-estradiol | 7 | 23136938 | 23342633 | Rat | 103 | old_gene_name | gene, protein-coding, VALIDATED [RefSeq] |
| 1615743 | Stab2 | stabilin 2 | Enables cargo receptor activity. Involved in hyaluronan catabolic process and receptor-mediated endocytosis. Predicted to be located in cytosol and external side of plasma membrane. Is expressed in several structures, including extraembryonic component; genitourinary system; gut; heart; and liver. O rthologous to human STAB2 (stabilin 2). [provided by Alliance of Genome Resources, Jul 2025] | 10 | 86677058 | 86843902 | Mouse | 119 | old_gene_name | gene, protein-coding, VALIDATED [RefSeq] |
| 2543 | Egfr | epidermal growth factor receptor | ENCODES a protein that exhibits calmodulin binding; epidermal growth factor binding; epidermal growth factor receptor activity; INVOLVED IN astrocyte activation; cellular response to dexamethasone stimulus; cellular response to epidermal growth factor stimulus; PARTICIPATES IN epidermal growth facto r/neuregulin signaling pathway; altered epidermal growth factor/neuregulin signaling pathway; cetuximab pharmacodynamics pathway; ASSOCIATED WITH abnormal estrous cycle; heart left ventricle hypertrophy; renal fibrosis; ASSOCIATED WITH acute kidney failure; asthma; bronchiolo-alveolar adenocarcinoma; FOUND IN apical plasma membrane; basolateral plasma membrane; cell surface; INTERACTS WITH (+)-pilocarpine; (R)-noradrenaline; (S)-nicotine | 14 | 95378626 | 95551358 | Rat | 1456 | symbol , old_gene_name , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 10511 | Egfr | epidermal growth factor receptor | Enables epidermal growth factor binding activity and epidermal growth factor receptor activity. Involved in ERBB2-EGFR signaling pathway; cellular response to amino acid stimulus; and positive regulation of fibroblast proliferation. Acts upstream of or within se veral processes, including eyelid development in camera-type eye; protein modification process; and regulation of epidermal growth factor receptor signaling pathway. Located in several cellular components, including basolateral plasma membrane; endocytic vesicle; and perinuclear region of cytoplasm. Is active in plasma membrane. Is expressed in several structures, including alimentary system; brain; integumental system; limb; and sensory organ. Used to study Coronavirus infectious disease and aortic valve disease. Human ortholog(s) of this gene implicated in several diseases, including colorectal cancer; lung cancer (multiple); pancreatic cancer; prostate cancer; and pulmonary tuberculosis. Orthologous to human EGFR (epidermal growth factor receptor). [provided by Alliance of Genome Resources, Apr 2025] | 11 | 16700153 | 16868158 | Mouse | 1899 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 69152 | EGFR | epidermal growth factor receptor | The protein encoded by this gene is a transmembrane glycoprotein that is a member of the protein kinase superfamily. This protein is a receptor for members of the epidermal growth factor family. EGFR is a cell surface protein that binds to epidermal growth facto r, thus inducing receptor dimerization and tyrosine autophosphorylation leading to cell proliferation. Mutations in this gene are associated with lung cancer. EGFR is a component of the cytokine storm which contributes to a severe form of Coronavirus Disease 2019 (COVID-19) resulting from infection with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). [provided by RefSeq, Jul 2020] | 7 | 55019017 | 55211628 | Human | 2280 | symbol , old_gene_name , COSMIC , description , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 8795990 | Egfr | epidermal growth factor receptor | ENCODES a protein that exhibits actin filament binding (ortholog); calmodulin binding (ortholog); chromatin binding (ortholog); INVOLVED IN astrocyte activation (ortholog); cell morphogenesis (ortholog); cell surface receptor signaling pathway (ortholog); PARTICIPATES IN altered epidermal growth fac tor/neuregulin signaling pathway; cetuximab pharmacodynamics pathway; E-cadherin signaling pathway; ASSOCIATED WITH acute kidney failure (ortholog); Acute Lung Injury (ortholog); adenocarcinoma (ortholog); FOUND IN apical plasma membrane (ortholog); basolateral plasma membrane (ortholog); cell junction (ortholog) | NW_004955456 | 321222 | 456431 | Chinchilla | 516 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11704382 | EGFR | epidermal growth factor receptor | ENCODES a protein that exhibits calmodulin binding (ortholog); epidermal growth factor binding (ortholog); epidermal growth factor receptor activity (ortholog); INVOLVED IN astrocyte activation (ortholog); cell morphogenesis (ortholog); cell surface receptor signaling pathway (ortholog); PARTICIPATE S IN altered epidermal growth factor/neuregulin signaling pathway; cetuximab pharmacodynamics pathway; E-cadherin signaling pathway; ASSOCIATED WITH acute kidney failure (ortholog); Acute Lung Injury (ortholog); adenocarcinoma (ortholog); FOUND IN apical plasma membrane (ortholog); basolateral plasma membrane (ortholog); cell surface (ortholog) | 7 | 55614042 | 55807285 | Bonobo | 526 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12340764 | EGFR | epidermal growth factor receptor | ENCODES a protein that exhibits calmodulin binding (ortholog); epidermal growth factor binding (ortholog); epidermal growth factor receptor activity (ortholog); INVOLVED IN astrocyte activation (ortholog); cell morphogenesis (ortholog); cell surface receptor signaling pathway (ortholog); PARTICIPATE S IN altered epidermal growth factor/neuregulin signaling pathway; cetuximab pharmacodynamics pathway; E-cadherin signaling pathway; ASSOCIATED WITH acute kidney failure (ortholog); Acute Lung Injury (ortholog); adenocarcinoma (ortholog); FOUND IN apical plasma membrane (ortholog); basolateral plasma membrane (ortholog); cell surface (ortholog) | 18 | 5983669 | 6044092 | Dog | 525 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12438149 | Egfr | epidermal growth factor receptor | ENCODES a protein that exhibits calmodulin binding (ortholog); epidermal growth factor binding (ortholog); epidermal growth factor receptor activity (ortholog); INVOLVED IN astrocyte activation (ortholog); cell morphogenesis (ortholog); cell surface receptor signaling pathway (ortholog); PARTICIPATE S IN altered epidermal growth factor/neuregulin signaling pathway; cetuximab pharmacodynamics pathway; E-cadherin signaling pathway; ASSOCIATED WITH acute kidney failure (ortholog); Acute Lung Injury (ortholog); adenocarcinoma (ortholog); FOUND IN apical plasma membrane (ortholog); basolateral plasma membrane (ortholog); cell surface (ortholog) | NW_004936678 | 365005 | 560546 | Squirrel | 529 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14383261 | Egfr | | | | | | Fly | | symbol | gene, null |
| 18783864 | EGFR | epidermal growth factor receptor | ENCODES a protein that exhibits calmodulin binding (ortholog); epidermal growth factor binding (ortholog); epidermal growth factor receptor activity (ortholog); INVOLVED IN astrocyte activation (ortholog); cell morphogenesis (ortholog); cell surface receptor signaling pathway (ortholog); PARTICIPATE S IN altered epidermal growth factor/neuregulin signaling pathway; cetuximab pharmacodynamics pathway; E-cadherin signaling pathway; ASSOCIATED WITH acute kidney failure (ortholog); Acute Lung Injury (ortholog); adenocarcinoma (ortholog); FOUND IN apical plasma membrane (ortholog); basolateral plasma membrane (ortholog); cell surface (ortholog) | | | | Green Monkey | 524 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18929855 | Egfr | epidermal growth factor receptor | ENCODES a protein that exhibits actin filament binding (ortholog); calmodulin binding (ortholog); chromatin binding (ortholog); INVOLVED IN astrocyte activation (ortholog); cell morphogenesis (ortholog); cell surface receptor signaling pathway (ortholog); PARTICIPATES IN altered epidermal growth fac tor/neuregulin signaling pathway; cetuximab pharmacodynamics pathway; E-cadherin signaling pathway; ASSOCIATED WITH acute kidney failure (ortholog); Acute Lung Injury (ortholog); adenocarcinoma (ortholog); FOUND IN apical plasma membrane (ortholog); basolateral plasma membrane (ortholog); cell junction (ortholog) | | | | Naked Mole-Rat | 526 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155254083 | egfr | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 625880722 | Egfr | epidermal growth factor receptor | ENCODES a protein that exhibits actin filament binding (ortholog); calmodulin binding (ortholog); chromatin binding (ortholog); INVOLVED IN astrocyte activation (ortholog); cell morphogenesis (ortholog); cell surface receptor signaling pathway (ortholog); PARTICIPATES IN altered epidermal growth fac tor/neuregulin signaling pathway; cetuximab pharmacodynamics pathway; E-cadherin signaling pathway; ASSOCIATED WITH acute kidney failure (ortholog); Acute Lung Injury (ortholog); adenocarcinoma (ortholog); FOUND IN apical plasma membrane (ortholog); basolateral plasma membrane (ortholog); cell junction (ortholog) | | | | Black Rat | 503 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155253937 | egfl6 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 155238572 | egfl7 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 155236189 | egfl8 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 155248443 | egflam | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 155238083 | egfr.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155247092 | egfr.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 1612813 | Egfros | epidermal growth factor receptor, opposite strand | | 11 | 16760001 | 16780750 | Mouse | 3 | symbol , PhenoGen | gene, ncrna, MODEL [RefSeq] |
| 155246787 | egfl6.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155236664 | egfl6.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 155247887 | egfl7.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155238571 | egfl7.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 155231111 | egfl8.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155236408 | egfl8.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 155248444 | egflam.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155247266 | egflam.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 7158345 | EGFR-AS1 | EGFR antisense RNA 1 | ASSOCIATED WITH Hereditary Neoplastic Syndromes; lung cancer; INTERACTS WITH 2-hydroxypropanoic acid; bis(2-ethylhexyl) phthalate; cadmium dichloride | 7 | 55179750 | 55188949 | Human | 17 | symbol , COSMIC , name , Human Proteome Map | gene, ncrna, VALIDATED [RefSeq] |
| 6481203 | EGFLAM-AS1 | EGFLAM antisense RNA 1 | | 5 | 38424855 | 38427376 | Human | | symbol , COSMIC , name , Human Proteome Map | gene, ncrna, VALIDATED [RefSeq] |
| 5132796 | EGFLAM-AS2 | EGFLAM antisense RNA 2 | | 5 | 38399814 | 38403471 | Human | | symbol , COSMIC , name , Human Proteome Map | gene, ncrna, VALIDATED [RefSeq] |
| 6481209 | EGFLAM-AS3 | EGFLAM antisense RNA 3 | | | | | Human | | symbol , COSMIC , name , Human Proteome Map | gene, ncrna |
| 5683645 | EGFLAM-AS4 | EGFLAM antisense RNA 4 | | 5 | 38282269 | 38290986 | Human | | symbol , COSMIC , name , Human Proteome Map | gene, ncrna, VALIDATED [RefSeq] |
| 16559186 | EGFLAM-AS5 | EGFLAM antisense RNA 5 | | | | | Human | | symbol , COSMIC , name , Human Proteome Map | gene, lncrna |
| 151669393 | EGFLAM-AS5 | EGFLAM antisense RNA 5 | | 5 | 38434501 | 38468366 | Human | | symbol , COSMIC , name , Human Proteome Map | gene, ncrna, VALIDATED [RefSeq] |
| 16554094 | LNCEGFL7OS | lncRNA EGFL7 opposite strand | INTERACTS WITH benzo[a]pyrene | 9 | 136648610 | 136660421 | Human | 1 | symbol , old_gene_name , COSMIC , name , Human Proteome Map | gene, ncrna, VALIDATED [RefSeq] |
| 7243718 | PPT2-EGFL8 | PPT2-EGFL8 readthrough (NMD candidate) | This locus represents naturally occurring read-through transcription between the neighboring PPT2 (palmitoyl-protein thioesterase 2) and EGFL8 (EGF-like-domain, multiple 8) genes located in the major histocompatibility compl ex class III region of chromosome 6. The read-through transcript is a candidate for nonsense-mediated mRNA decay (NMD), and is thus unlikely to produce a protein product. [provided by RefSeq, Feb 2011] | 6 | 32153999 | 32168285 | Human | 5 | symbol , COSMIC , name , description , Human Proteome Map | gene, ncrna, VALIDATED [RefSeq] |
| 152999024 | Aif1tm(EGFP)Apps | allograft inflammatory factor 1; target mutant 1,Apps | Applied StemCell, Inc (Milpitas, CA) was contracted to generate the Iba1-EGFP knock-in rat model using CRISPR/Cas9 technology in the Sprague Dawley rat strain. The donor construct inserted consisted of the EGFP coding sequen ce (minus the first ATG), followed by the 22 amino acid sequence of the porcine teschovirus-1 2A (P2A) self-cleaving peptide, and then the first exon of the rat Iba1 gene immediately downstream of the translational start site. Guide RNA with the following sequence: 5'- TACCCTGCAAATCCTTGCTCTGG-3' targeting the Iba1 gene just downstream of the translational start site were used. | | | | Rat | | symbol , description | gene, allele |
| 126781692 | Csf1rtm(EGFP)Tset | colony stimulating factor 1 receptor; target mutant, Tset | ASSOCIATED WITH abnormal brain development; abnormal corpus callosum size; absent teeth; ASSOCIATED WITH bone development disease; infertility; lymphopenia | | | | Rat | 27 | symbol | gene, allele |
| 12792957 | Tp53tm1(EGFP-Pac)Qly | tumor protein p53; tm1, EGFP-Pac, Qly | This allele was made by electroporation of DAc8 embryonic stem cells with a targeting vector containing 6.7kb 5' and 1.6- kb 3' homology arms and a CAG-EGFP-IRES-Pac cassette. Absence of Tp53 protein was confirmed by western blot in homozygous animals. | | | | Rat | | symbol , name , description , old_gene_symbol | gene, allele |
| 1604558 | GFM1 | G elongation factor mitochondrial 1 | Eukaryotes contain two protein translational systems, one in the cytoplasm and one in the mitochondria. Mitochondrial translation is crucial for maintaining mitochondrial function and mutations in this system lead to a breakdown in the respiratory chain-oxidative phosphorylation system and to impair ed maintenance of mitochondrial DNA. This gene encodes one of the mitochondrial translation elongation factors. Its role in the regulation of normal mitochondrial function and in different disease states attributed to mitochondrial dysfunction is not known. [provided by RefSeq, Jul 2008] | 3 | 158644527 | 158695581 | Human | 182 | old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 1312891 | Rhbdf1 | rhomboid 5 homolog 1 | Predicted to enable serine-type endopeptidase activity. Predicted to be involved in several processes, including negative regulation of protein secretion; regulation of epidermal growth factor receptor signaling pathway; and regulation of proteasomal protein catabolic process. Predicted to be locate d in Golgi membrane. Predicted to be active in endoplasmic reticulum membrane. Is expressed in several structures, including alimentary system; brain; early conceptus; eye; and genitourinary system. Orthologous to human RHBDF1 (rhomboid 5 homolog 1). [provided by Alliance of Genome Resources, Apr 2025] | 11 | 32159585 | 32172339 | Mouse | 187 | old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 1621802 | Klk13 | kallikrein related-peptidase 13 | Kallikreins are serine proteases encoded by a cluster of highly related genes on chromosome 7. When genomic sequence became available, it was possible to clarify the gene-to-sequence relationship for this family. Until January, 2006, NM_010115 was called kallikrein 13. After that time, NM_001039042 was called Klk13 and NM_010115 was called Klk1b26. [provided by RefSeq, Jul 2008] | 7 | 43361991 | 43377288 | Mouse | 58 | old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 1312890 | RHBDF1 | rhomboid 5 homolog 1 | Predicted to enable growth factor binding activity and serine-type endopeptidase activity. Involved in several processes, including negative regulation of protein secretion; regulation of epidermal growth factor receptor signaling pathway; and regulation of proteasomal protein catabolic process. Loc ated in Golgi membrane and endoplasmic reticulum membrane. [provided by Alliance of Genome Resources, Jul 2025] | 16 | 58059 | 76360 | Human | 130 | old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 18183029 | EGILA | EGFR interacting lncRNA | | 14 | 20693480 | 20706941 | Human | | name , old_gene_symbol | gene, ncrna, VALIDATED [RefSeq] |
| 1617450 | Nup210l | nucleoporin 210-like | Acts upstream of or within Sertoli cell development and spermatid development. Predicted to be located in membrane. Predicted to be part of nuclear pore. Orthologous to human NUP210L (nucleoporin 210 like). [provided by Alliance of Genome Resources, Apr 2025] | 3 | 90011445 | 90119458 | Mouse | 50 | old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 732473 | GRB2 | growth factor receptor bound protein 2 | The protein encoded by this gene binds the epidermal growth factor receptor and contains one SH2 domain and two SH3 domains. Its two SH3 domains direct complex formation with proline-rich regions of other proteins, and its SH2 domain binds tyrosine phosphorylated sequences. This gene is similar to t he Sem5 gene of C.elegans, which is involved in the signal transduction pathway. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] | 17 | 75318076 | 75405678 | Human | 391 | old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 1618321 | 1700016L21Rik | RIKEN cDNA 1700016L21 gene | ASSOCIATED WITH abnormal alveolar macrophage morphology; abnormal CD8-positive, alpha-beta T cell differentiation; abnormal circulating cytokine level | 1 | 80423649 | 80453377 | Mouse | 56 | old_gene_symbol | gene, ncrna, VALIDATED [RefSeq] |
| 736353 | BTC | betacellulin | This gene encodes a member of the epidermal growth factor (EGF) family of proteins. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the secreted growth fact or. A secreted form and a membrane-anchored form of this protein bind to multiple different EGF receptors. This protein promotes pancreatic cell proliferation and insulin secretion, as well as retinal vascular permeability. Mutations in this gene may be associated with type 2 diabetes in human patients. [provided by RefSeq, Nov 2015] | 4 | 74744759 | 74794523 | Human | 138 | description | gene, protein-coding, REVIEWED [RefSeq] |
| 1605117 | DEGS1 | delta 4-desaturase, sphingolipid 1 | This gene encodes a member of the membrane fatty acid desaturase family which is responsible for inserting double bonds into specific positions in fatty acids. This protein contains three His-containing consensus motifs that are characteristic of a group of membrane fatty acid desaturases. It is pre dicted to be a multiple membrane-spanning protein localized to the endoplasmic reticulum. Overexpression of this gene inhibited biosynthesis of the EGF receptor, suggesting a possible role of a fatty acid desaturase in regulating biosynthetic processing of the EGF receptor. [provided by RefSeq, Mar 2010] | 1 | 224183240 | 224193441 | Human | 170 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 619563 | ERBB2 | erb-b2 receptor tyrosine kinase 2 | This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF style='font-weight:700;'>EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654/Ile655, shown here. Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized. [provided by RefSeq, Jul 2008] | 17 | 39688094 | 39728658 | Human | 968 | description | gene, protein-coding, REVIEWED [RefSeq] |
| 1625085 | GXYLT2 | glucoside xylosyltransferase 2 | The protein encoded by this gene is a xylosyltransferase that elongates O-linked glucose bound to epidermal growth factor (EGF) repeats. The encoded protein catalyzes the addition of xylose to the O-glucose-modified residues of EGF repeats of Notch proteins. [provided by RefSeq, Sep 2016] | 3 | 72888046 | 72976915 | Human | 99 | description | gene, protein-coding, REVIEWED [RefSeq] |
| 1314206 | SPART | spartin | This gene encodes a protein containing a MIT (Microtubule Interacting and Trafficking molecule) domain, and is implicated in regulating endosomal trafficking and mitochondria function. The protein localizes to mitochondria and partially co-localizes with microtubules. Stimulation with epidermal grow th factor (EGF) results in protein translocation to the plasma membrane, and the protein functions in the degradation and intracellular trafficking of EGF receptor. Multiple alternatively spliced variants, encoding the same protein, have been identified. Mutations associated with this gene cause autosomal recessive spastic paraplegia 20 (Troyer syndrome). [provided by RefSeq, Nov 2008] | 13 | 36301638 | 36370180 | Human | 242 | description | gene, protein-coding, REVIEWED [RefSeq] |
| 11411 | Tgfa | transforming growth factor alpha | This gene encodes a member of the epidermal growth factor (EGF) family of proteins that regulate cellular proliferation. The encoded protein undergoes proteolytic processing to generate a soluble glycoprotein that is secreted by the cell. The secreted protein bi nds to the EGF receptors to initiate signaling events resulting in cellular proliferation, mucous production or inhibition of gastric acid secretion. The transgenic expression of the encoded protein in mice induces the development of cancers in various tissues such as liver, pancreas, skin and mammary glands. Mice lacking the encoded protein exhibit a wavy coat and curly whiskers phenotype as well as abnormalities in the eye. [provided by RefSeq, Sep 2015] | 6 | 86172020 | 86252726 | Mouse | 492 | description | gene, protein-coding, REVIEWED [RefSeq] |
| 8886442 | Msantd3 | Myb/SANT DNA binding domain containing 3 | | NW_004955419 | 25305885 | 25329518 | Chinchilla | 1 | ensembl_full_name | gene, protein-coding, MODEL [RefSeq] |
| 733223 | ADAM15 | ADAM metallopeptidase domain 15 | The protein encoded by this gene is a member of the ADAM (a disintegrin and metalloproteinase) protein family. ADAM family members are type I transmembrane glycoproteins known to be involved in cell adhesion and proteolytic ectodomain processing of cytokines and adhesion molecules. This protein cont ains multiple functional domains including a zinc-binding metalloprotease domain, a disintegrin-like domain, as well as a EGF-like domain. Through its disintegrin-like domain, this protein specifically interacts with the integrin beta chain, beta 3. It also interacts with Src family protein-tyrosine kinases in a phosphorylation-dependent manner, suggesting that this protein may function in cell-cell adhesion as well as in cellular signaling. Multiple alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008] | 1 | 155051316 | 155062775 | Human | 146 | description | gene, protein-coding, REVIEWED [RefSeq] |
| 731400 | ADAM17 | ADAM metallopeptidase domain 17 | This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biologic processes involving cell-cell and cell-matrix interactio ns, including fertilization, muscle development, and neurogenesis. The encoded preproprotein is proteolytically processed to generate the mature protease. The encoded protease functions in the ectodomain shedding of tumor necrosis factor-alpha, in which soluble tumor necrosis factor-alpha is released from the membrane-bound precursor. This protease also functions in the processing of numerous other substrates, including cell adhesion proteins, cytokine and growth factor receptors and epidermal growth factor (EGF) receptor ligands, and plays a prominent role in the activation of the Notch signaling pathway. Elevated expression of this gene has been observed in specific cell types derived from psoriasis, rheumatoid arthritis, multiple sclerosis and Crohn's disease patients, suggesting that the encoded protein may play a role in autoimmune disease. Additionally, this protease may play a role in viral infection through its cleavage of ACE2, the cellular receptor for SARS-CoV and SARS-CoV-2. [provided by RefSeq, Aug 2020] | 2 | 9488486 | 9555830 | Human | 388 | description | gene, protein-coding, REVIEWED [RefSeq] |
| 1321127 | ADAM9 | ADAM metallopeptidase domain 9 | This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interact ions, including fertilization, muscle development, and neurogenesis. The protein encoded by this gene interacts with SH3 domain-containing proteins, binds mitotic arrest deficient 2 beta protein, and is also involved in TPA-induced ectodomain shedding of membrane-anchored heparin-binding EGF-like growth factor. Several alternatively spliced transcript variants have been identified for this gene. [provided by RefSeq, Jul 2010] | 8 | 38996973 | 39105261 | Human | 281 | description | gene, protein-coding, REVIEWED [RefSeq] |
| 1606914 | ADGRE4P | adhesion G protein-coupled receptor E4, pseudogene | This gene is a member of the EGF-TM7 receptor gene family which is thought to play a role in leukocyte adhesion and migration. In other vertebrates, including nonhuman primates, this gene encodes a protein containing N-terminal EGF domains and a C-terminal transmembrane domain. Sequence evidence for the human gene, however, indicates nucleotide deletion in the genomic sequence would result in frameshift and early termination of translation. A protein expressed by this gene would be soluble rather than expressed on the cell surface. As the encoded protein has not been detected, this gene may represent a transcribed pseudogene. [provided by RefSeq, Aug 2008] | 19 | 6950758 | 6997851 | Human | 81 | description | gene, pseudo, VALIDATED [RefSeq] |
| 1313717 | ADGRE5 | adhesion G protein-coupled receptor E5 | This gene encodes a member of the EGF-TM7 subfamily of adhesion G protein-coupled receptors, which mediate cell-cell interactions. These proteins are cleaved by self-catalytic proteolysis into a large extracellular subunit and seven-span transmembrane subunit, w hich associate at the cell surface as a receptor complex. The encoded protein may play a role in cell adhesion as well as leukocyte recruitment, activation and migration, and contains multiple extracellular EGF-like repeats which mediate binding to chondroitin sulfate and the cell surface complement regulatory protein CD55. Expression of this gene may play a role in the progression of several types of cancer. Alternatively spliced transcript variants encoding multiple isoforms with 3 to 5 EGF-like repeats have been observed for this gene. This gene is found in a cluster with other EGF-TM7 genes on the short arm of chromosome 19. [provided by RefSeq, Jun 2011] | 19 | 14381444 | 14408723 | Human | 150 | description | gene, protein-coding, REVIEWED [RefSeq] |
| 735336 | Akt1 | Akt serine/threonine kinase 1 | This gene encodes the founding member of the Akt serine-threonine protein kinase gene family that also includes Akt2 and Akt3. This kinase is a major downstream effector of the phosphatidylinositol 3-kinase (PI3K) pathway that mediates the effects of various growth factors such as platelet-derived g rowth factor (PDGF), epidermal growth factor (EGF), insulin and insulin-like growth factor I (IGF-I). It is activated through recruitment to cellular membranes by PI3K lipid products and by phosphorylation by 3-phosphoinositide dependent kinase-1. It then further phosphorylates different downstream proteins in response to various extracellular signals and thus plays a pivotal role in mediating a variety of cellular processes, such as glucose metabolism, glycogen biosynthesis, protein synthesis and turn over, inflammatory response, cell survival (anti-apoptosis) and development. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009] | 12 | 112620260 | 112641266 | Mouse | 3290 | description | gene, protein-coding, REVIEWED [RefSeq] |
| 1607055 | APPL1 | adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1 | The protein encoded by this gene has been shown to be involved in the regulation of cell proliferation, and in the crosstalk between the adiponectin signalling and insulin signalling pathways. The encoded protein binds many other proteins, including RAB5A, DCC, AKT2, PIK3CA, adiponectin receptors, a nd proteins of the NuRD/MeCP1 complex. This protein is found associated with endosomal membranes, but can be released by EGF and translocated to the nucleus. [provided by RefSeq, Jul 2008] | 3 | 57227729 | 57273471 | Human | 245 | description | gene, protein-coding, REVIEWED [RefSeq] |
| 1605653 | APPL2 | adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2 | The protein encoded by this gene is one of two effectors of the small GTPase RAB5A/Rab5, which are involved in a signal transduction pathway. Both effectors contain an N-terminal Bin/Amphiphysin/Rvs (BAR) domain, a central pleckstrin homology (PH) domain, and a C-terminal phosphotyrosine binding (PT B) domain, and they bind the Rab5 through the BAR domain. They are associated with endosomal membranes and can be translocated to the nucleus in response to the EGF stimulus. They interact with the NuRD/MeCP1 complex (nucleosome remodeling and deacetylase /methyl-CpG-binding protein 1 complex) and are required for efficient cell proliferation. A chromosomal aberration t(12;22)(q24.1;q13.3) involving this gene and the PSAP2 gene results in 22q13.3 deletion syndrome, also known as Phelan-McDermid syndrome. [provided by RefSeq, Oct 2011] | 12 | 105173300 | 105236174 | Human | 199 | description | gene, protein-coding, REVIEWED [RefSeq] |
| 736382 | Areg | amphiregulin | This gene encodes a member of the epidermal growth factor (EGF) family and preproprotein that is proteolytically processed to generate a mature protein product. The encoded protein is a ligand of the epidermal growth factor receptor (EGF ;'>EGFR) and has been shown to play a role in immunity, inflammation, tissue repair, and lung and mammary gland development. Homozygous knockout mice for this gene exhibit impaired immune system regulation in the skin and gene expression changes characteristic of chronic liver damage. [provided by RefSeq, Aug 2015] | 5 | 91287458 | 91296291 | Mouse | 486 | description | gene, protein-coding, REVIEWED [RefSeq] |
| 1345760 | AREG | amphiregulin | The protein encoded by this gene is a member of the epidermal growth factor family. It is an autocrine growth factor as well as a mitogen for astrocytes, Schwann cells and fibroblasts. It is related to epidermal growth factor (EGF) and transforming growth factor alpha (TGF-alpha). The protein interacts with the EGF/TGF-alpha receptor to promote the growth of normal epithelial cells, and it inhibits the growth of certain aggressive carcinoma cell lines. It also functions in mammary gland, oocyte and bone tissue development. This gene is associated with a psoriasis-like skin phenotype, and is also associated with other pathological disorders, including various types of cancers and inflammatory conditions. [provided by RefSeq, Apr 2014] | 4 | 74445136 | 74455005 | Human | 453 | description | gene, protein-coding, REVIEWED [RefSeq] |
| 1323751 | ASPH | aspartate beta-hydroxylase | This gene is thought to play an important role in calcium homeostasis. The gene is expressed from two promoters and undergoes extensive alternative splicing. The encoded set of proteins share varying amounts of overlap near their N-termini but have substantial variations in their C-terminal domains resulting in distinct functional properties. The longest isoforms (a and f) include a C-terminal Aspartyl/Asparaginyl beta-hydroxylase domain that hydroxylates aspartic acid or asparagine residues in the epidermal growth factor (EGF)-like domains of some proteins, including protein C, coagulation factors VII, IX, and X, and the complement factors C1R and C1S. Other isoforms differ primarily in the C-terminal sequence and lack the hydroxylase domain, and some have been localized to the endoplasmic and sarcoplasmic reticulum. Some of these isoforms are found in complexes with calsequestrin, triadin, and the ryanodine receptor, and have been shown to regulate calcium release from the sarcoplasmic reticulum. Some isoforms have been implicated in metastasis. [provided by RefSeq, Sep 2009] | 8 | 61500556 | 61714592 | Human | 375 | description | gene, protein-coding, REVIEWED [RefSeq] |
| 733574 | Btc | betacellulin, epidermal growth factor family member | This gene encodes a member of the epidermal growth factor (EGF) family. These growth factors are ligands for the EGFR/ErbB receptor tyrosine kinases, and play roles in cell growth and differentiation. The encoded protein is synthesized as a transmembrane precursor that is proteolytically cleaved to generate a mature peptide, and plays a role in the differentiation of pancreatic beta cells. This gene may also play a protective role in acute pancreatitis, whereas increased expression of this gene may contribute to diabetic macular edema. Gene therapy using combinations of this gene and other pancreas-specific transcription factors may induce islet neogenesis and remediate hyperglycemia in type 1 diabetes. [provided by RefSeq, Apr 2011] | 5 | 91505120 | 91550853 | Mouse | 163 | description | gene, protein-coding, REVIEWED [RefSeq] |
| 1606954 | CCDC50 | coiled-coil domain containing 50 | This gene encodes a soluble, cytoplasmic, tyrosine-phosphorylated protein with multiple ubiquitin-interacting domains. Mutations in this gene cause nonsyndromic, postlingual, progressive sensorineural DFNA44 hearing loss. In mouse, the protein is expressed in the inner ear during development and pos tnatal maturation and associates with microtubule-based structures. This protein may also function as a negative regulator of NF-kB signaling and as an effector of epidermal growth factor (EGF)-mediated cell signaling. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Oct 2008] | 3 | 191329394 | 191398659 | Human | 106 | description | gene, protein-coding, REVIEWED [RefSeq] |
| 736605 | COMP | cartilage oligomeric matrix protein | The protein encoded by this gene is a noncollagenous extracellular matrix (ECM) protein. It consists of five identical glycoprotein subunits, each with EGF-like and calcium-binding (thrombospondin-like) domains. Oligomerization results from formation of a five-s tranded coiled coil and disulfides. Binding to other ECM proteins such as collagen appears to depend on divalent cations. Contraction or expansion of a 5 aa aspartate repeat and other mutations can cause pseudochondroplasia (PSACH) and multiple epiphyseal dysplasia (MED). [provided by RefSeq, Jul 2016] | 19 | 18782773 | 18791305 | Human | 399 | description | gene, protein-coding, REVIEWED [RefSeq] |
| 735462 | DLL3 | delta like canonical Notch ligand 3 | This gene encodes a member of the delta protein ligand family. This family functions as Notch ligands that are characterized by a DSL domain, EGF repeats, and a transmembrane domain. Mutations in this gene cause autosomal recessive spondylocostal dysostosis 1. T wo transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008] | 19 | 39498947 | 39508469 | Human | 298 | description | gene, protein-coding, REVIEWED [RefSeq] |
| 1320241 | DLL4 | delta like canonical Notch ligand 4 | This gene is a homolog of the Drosophila delta gene. The delta gene family encodes Notch ligands that are characterized by a DSL domain, EGF repeats, and a transmembrane domain. [provided by RefSeq, Jul 2008] | 15 | 40929340 | 40939073 | Human | 399 | description | gene, protein-coding, REVIEWED [RefSeq] |
| 2303680 | ECSCR | endothelial cell surface expressed chemotaxis and apoptosis regulator | The protein encoded by this gene is primarily found in endothelial cells and blood vessels, where it is involved in cell shape changes and EGF-induced cell migration. It can enhance the activation of vascular endothelial growth factor receptor-2/kinase insert do main receptor and also promote the proteolysis of internalized kinase insert domain receptor. This gene may play a role in angiogenesis-related diseases. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014] | 5 | 139448560 | 139462743 | Human | 63 | description | gene, protein-coding, REVIEWED [RefSeq] |
| 1313642 | EPS15 | epidermal growth factor receptor pathway substrate 15 | This gene encodes a protein that is part of the EGFR pathway. The protein is present at clatherin-coated pits and is involved in receptor-mediated endocytosis of EGF. Notably, this gene is rearranged with the HRX/ALL/MLL gen e in acute myelogeneous leukemias. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, May 2009] | 1 | 51354263 | 51519266 | Human | 169 | description | gene, protein-coding, REVIEWED [RefSeq] |
| 733426 | ERBB3 | erb-b2 receptor tyrosine kinase 3 | This gene encodes a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound protein has a neuregulin binding domain but not an active kinase domain. It therefore can bind this ligand but not convey the signa l into the cell through protein phosphorylation. However, it does form heterodimers with other EGF receptor family members which do have kinase activity. Heterodimerization leads to the activation of pathways which lead to cell proliferation or differentiation. Amplification of this gene and/or overexpression of its protein have been reported in numerous cancers, including prostate, bladder, and breast tumors. Alternate transcriptional splice variants encoding different isoforms have been characterized. One isoform lacks the intermembrane region and is secreted outside the cell. This form acts to modulate the activity of the membrane-bound form. Additional splice variants have also been reported, but they have not been thoroughly characterized. [provided by RefSeq, Jul 2008] | 12 | 56080108 | 56103505 | Human | 505 | description | gene, protein-coding, REVIEWED [RefSeq] |
| 730898 | EREG | epiregulin | This gene encodes a secreted peptide hormone and member of the epidermal growth factor (EGF) family of proteins. The encoded protein is a ligand of the epidermal growth factor receptor (EGFR) and the structurally related erb -b2 receptor tyrosine kinase 4 (ERBB4). The encoded protein may be involved in a wide range of biological processes including inflammation, wound healing, oocyte maturation, and cell proliferation. Additionally, the encoded protein may promote the progression of cancers of various human tissues. [provided by RefSeq, Jul 2015] | 4 | 74365145 | 74388749 | Human | 351 | description | gene, protein-coding, REVIEWED [RefSeq] |
| 1342967 | F10 | coagulation factor X | This gene encodes the vitamin K-dependent coagulation factor X of the blood coagulation cascade. This factor undergoes multiple processing steps before its preproprotein is converted to a mature two-chain form by the excision of the tripeptide RKR. Two chains of the factor are held together by 1 or more disulfide bonds; the light chain contains 2 EGF-like domains, while the heavy chain contains the catalytic domain which is structurally homologous to those of the other hemostatic serine proteases. The mature factor is activated by the cleavage of the activation peptide by factor IXa (in the intrisic pathway), or by factor VIIa (in the extrinsic pathway). The activated factor then converts prothrombin to thrombin in the presence of factor Va, Ca+2, and phospholipid during blood clotting. Mutations of this gene result in factor X deficiency, a hemorrhagic condition of variable severity. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar proteolytic processing to generate mature polypeptides. [provided by RefSeq, Aug 2015] | 13 | 113122799 | 113149529 | Human | 313 | description | gene, protein-coding, REVIEWED [RefSeq] |
| 1345372 | F12 | coagulation factor XII | This gene encodes coagulation factor XII which circulates in blood as a zymogen. This single chain zymogen is converted to a two-chain serine protease with an heavy chain (alpha-factor XIIa) and a light chain. The heavy chain contains two fibronectin-type domains, two epidermal growth factor (EGF style='font-weight:700;'>EGF)-like domains, a kringle domain and a proline-rich domain, whereas the light chain contains only a catalytic domain. On activation, further cleavages takes place in the heavy chain, resulting in the production of beta-factor XIIa light chain and the alpha-factor XIIa light chain becomes beta-factor XIIa heavy chain. Prekallikrein is cleaved by factor XII to form kallikrein, which then cleaves factor XII first to alpha-factor XIIa and then to beta-factor XIIa. The active factor XIIa participates in the initiation of blood coagulation, fibrinolysis, and the generation of bradykinin and angiotensin. It activates coagulation factors VII and XI. Defects in this gene do not cause any clinical symptoms and the sole effect is that whole-blood clotting time is prolonged. [provided by RefSeq, Jul 2008] | 5 | 177402141 | 177409564 | Human | 327 | description | gene, protein-coding, REVIEWED [RefSeq] |
| 1345586 | F7 | coagulation factor VII | This gene encodes coagulation factor VII which is a vitamin K-dependent factor essential for hemostasis. This factor circulates in the blood in a zymogen form, and is converted to an active form by either factor IXa, factor Xa, factor XIIa, or thrombin by minor proteolysis. Upon activation of the fa ctor VII, a heavy chain containing a catalytic domain and a light chain containing 2 EGF-like domains are generated, and two chains are held together by a disulfide bond. In the presence of factor III and calcium ions, the activated factor then further activates the coagulation cascade by converting factor IX to factor IXa and/or factor X to factor Xa. Defects in this gene can cause coagulopathy. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar proteolytic processing to generate mature polypeptides. [provided by RefSeq, Aug 2015] | 13 | 113105791 | 113120685 | Human | 577 | description | gene, protein-coding, REVIEWED [RefSeq] |
| 732531 | FAT1 | FAT atypical cadherin 1 | This gene is an ortholog of the Drosophila fat gene, which encodes a tumor suppressor essential for controlling cell proliferation during Drosophila development. The gene product is a member of the cadherin superfamily, a group of integral membrane proteins characterized by the presence of cadherin- type repeats. In addition to containing 34 tandem cadherin-type repeats, the gene product has five epidermal growth factor (EGF)-like repeats and one laminin A-G domain. This gene is expressed at high levels in a number of fetal epithelia. Its product probably functions as an adhesion molecule and/or signaling receptor, and is likely to be important in developmental processes and cell communication. Transcript variants derived from alternative splicing and/or alternative promoter usage exist, but they have not been fully described. [provided by RefSeq, Jul 2008] | 4 | 186587794 | 186726696 | Human | 279 | description | gene, protein-coding, REVIEWED [RefSeq] |
| 1342843 | GAREM1 | GRB2 associated regulator of MAPK1 subtype 1 | This gene encodes an adaptor protein which functions in the epidermal growth factor (EGF) receptor-mediated signaling pathway. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011] | 18 | 32263522 | 32470882 | Human | 97 | description | gene, protein-coding, REVIEWED [RefSeq] |
| 1601901 | GPR179 | G protein-coupled receptor 179 | This gene encodes a member of the glutamate receptor subfamily of G protein-coupled receptors. The encoded protein has an EGF-like calcium binding domain and a seven transmembrane domain in the N-terminal region of the protein. Mutations in this gene are associa ted with congenital stationary night blindness type 1E. [provided by RefSeq, Apr 2012] | 17 | 38324571 | 38343956 | Human | 153 | description | gene, protein-coding, REVIEWED [RefSeq] |
| 1606923 | GXYLT1 | glucoside xylosyltransferase 1 | GXYLT1 is a xylosyltransferase (EC 2.4.2.-) that adds the first xylose to O-glucose-modified residues in the epidermal growth factor (EGF; MIM 131530) repeats of proteins such as NOTCH1 (MIM 190198) (Sethi et al., 2010 [PubMed 19940119]).[supplied by OMIM, Mar 2 010] | 12 | 42081845 | 42144874 | Human | 84 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 1314859 | LAMB1 | laminin subunit beta 1 | Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Laminins are composed of 3 non identical chains: laminin alpha, beta and gamma (formerly A, B1, and B2, respectively) and they form a cruciform structure consisting of 3 short arms, each formed by a different chain, and a long arm composed of all 3 chains. Each laminin chain is a multidomain protein encoded by a distinct gene. Several isoforms of each chain have been described. Different alpha, beta and gamma chain isomers combine to give rise to different heterotrimeric laminin isoforms which are designated by Arabic numerals in the order of their discovery, i.e. alpha1beta1gamma1 heterotrimer is laminin 1. The biological functions of the different chains and trimer molecules are largely unknown, but some of the chains have been shown to differ with respect to their tissue distribution, presumably reflecting diverse functions in vivo. This gene encodes the beta chain isoform laminin, beta 1. The beta 1 chain has 7 structurally distinct domains which it shares with other beta chain isomers. The C-terminal helical region containing domains I and II are separated by domain alpha, domains III and V contain several EGF-like repeats, and domains IV and VI have a globular conformation. Laminin, beta 1 is expressed in most tissues that produce basement membranes, and is one of the 3 chains constituting laminin 1, the first laminin isolated from Engelbreth-Holm-Swarm (EHS) tumor. A sequence in the beta 1 chain that is involved in cell attachment, chemotaxis, and binding to the laminin receptor was identified and shown to have the capacity to inhibit metastasis. [provided by RefSeq, Aug 2011] | 7 | 107923799 | 108003161 | Human | 306 | description | gene, protein-coding, REVIEWED [RefSeq] |
| 733264 | NELL1 | neural EGFL like 1 | This gene encodes a cytoplasmic protein that contains epidermal growth factor (EGF)-like repeats. The encoded heterotrimeric protein may be involved in cell growth regulation and differentiation. A similar protein in rodents is involved in craniosynostosis. Alte rnative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013] | 11 | 20669551 | 21575686 | Human | 119 | name , description | gene, protein-coding, REVIEWED [RefSeq] |
| 732316 | NELL2 | neural EGFL like 2 | The protein encoded by this gene is a glycoprotein containing several von Willebrand factor C domains and epidermal growth factor (EGF)-like domains. The encoded protein acts as a homotrimer and is found in the cytoplasm. Several variants encoding a few differen t isoforms exist, and at least one isoform appears to be a secreted protein. Studies in mouse suggest that this protein plays a role in neural cell growth and differentiation as well as in oncogenesis. [provided by RefSeq, Feb 2009] | 12 | 44508275 | 44921848 | Human | 141 | name , description | gene, protein-coding, REVIEWED [RefSeq] |
| 737367 | NOTCH1 | notch receptor 1 | This gene encodes a member of the NOTCH family of proteins. Members of this Type I transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracell ular domain consisting of multiple different domain types. Notch signaling is an evolutionarily conserved intercellular signaling pathway that regulates interactions between physically adjacent cells through binding of Notch family receptors to their cognate ligands. The encoded preproprotein is proteolytically processed in the trans-Golgi network to generate two polypeptide chains that heterodimerize to form the mature cell-surface receptor. This receptor plays a role in the development of numerous cell and tissue types. Mutations in this gene are associated with aortic valve disease, Adams-Oliver syndrome, T-cell acute lymphoblastic leukemia, chronic lymphocytic leukemia, and head and neck squamous cell carcinoma. [provided by RefSeq, Jan 2016] | 9 | 136494433 | 136546048 | Human | 1616 | description | gene, protein-coding, REVIEWED [RefSeq] |
| 733357 | NOTCH2 | notch receptor 2 | This gene encodes a member of the Notch family. Members of this Type 1 transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple, different domain types. Notch family members play a role in a variety of developmental processes by controlling cell fate decisions. The Notch signaling network is an evolutionarily conserved intercellular signaling pathway which regulates interactions between physically adjacent cells. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signaling pathway that plays a key role in development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remain to be determined. This protein is cleaved in the trans-Golgi network, and presented on the cell surface as a heterodimer. This protein functions as a receptor for membrane bound ligands, and may play a role in vascular, renal and hepatic development. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2011] | 1 | 119911553 | 120069662 | Human | 670 | description | gene, protein-coding, REVIEWED [RefSeq] |
| 1354309 | NOTCH4 | notch receptor 4 | This gene encodes a member of the NOTCH family of proteins. Members of this Type I transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracell ular domain consisting of multiple different domain types. Notch signaling is an evolutionarily conserved intercellular signaling pathway that regulates interactions between physically adjacent cells through binding of Notch family receptors to their cognate ligands. The encoded preproprotein is proteolytically processed in the trans-Golgi network to generate two polypeptide chains that heterodimerize to form the mature cell-surface receptor. This receptor may play a role in vascular, renal and hepatic development. Mutations in this gene may be associated with schizophrenia. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Jan 2016] | 6 | 32194843 | 32224067 | Human | 213 | description | gene, protein-coding, REVIEWED [RefSeq] |
| 731928 | NRDC | nardilysin convertase | This gene encodes a zinc-dependent endopeptidase that cleaves peptide substrates at the N-terminus of arginine residues in dibasic moieties and is a member of the peptidase M16 family. This protein interacts with heparin-binding EGF-like growth factor and plays a role in cell migration and proliferation. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2011] | 1 | 51789210 | 51878727 | Human | 91 | description | gene, protein-coding, REVIEWED [RefSeq] |
| 735900 | NRXN2 | neurexin 2 | This gene encodes a member of the neurexin gene family. The products of these genes function as cell adhesion molecules and receptors in the vertebrate nervous system. These genes utilize two promoters. The majority of transcripts are produced from the upstream promoter and encode alpha-neurexin iso forms while a smaller number of transcripts are produced from the downstream promoter and encode beta-neuresin isoforms. The alpha-neurexins contain epidermal growth factor-like (EGF-like) sequences and laminin G domains, and have been shown to interact with neurexophilins. The beta-neurexins lack EGF-like sequences and contain fewer laminin G domains than alpha-neurexins. Alternative splicing and the use of alternative promoters may generate thousands of transcript variants (PMID: 12036300, PMID: 11944992).[provided by RefSeq, Jun 2010] | 11 | 64606174 | 64723197 | Human | 195 | description | gene, protein-coding, REVIEWED [RefSeq] |
| 1353595 | NRXN3 | neurexin 3 | This gene encodes a member of a family of proteins that function in the nervous system as receptors and cell adhesion molecules. Extensive alternative splicing and the use of alternative promoters results in multiple transcript variants and protein isoforms for this gene, but the full-length nature of many of these variants has not been determined. Transcripts that initiate from an upstream promoter encode alpha isoforms, which contain epidermal growth factor-like (EGF-like) sequences and laminin G domains. Transcripts initiating from the downstream promoter encode beta isoforms, which lack EGF-like sequences. Genetic variation at this locus has been associated with a range of behavioral phenotypes, including alcohol dependence and autism spectrum disorder. [provided by RefSeq, Dec 2012] | 14 | 78170373 | 79868291 | Human | 195 | description | gene, protein-coding, REVIEWED [RefSeq] |
| 1553035 | Nrxn3 | neurexin III | This gene encodes a member of a family of proteins that function in the nervous system as receptors and cell adhesion molecules. Extensive alternative splicing and the use of alternative promoters results in multiple transcript variants for this gene, but the full-length nature of many of these vari ants has not been determined. Transcripts that initiate from an upstream promoter encode alpha isoforms, which contain epidermal growth factor-like (EGF-like) sequences and laminin G domains. Transcripts initiating from the downstream promoter encode beta isoforms, which lack EGF-like sequences. [provided by RefSeq, Dec 2012] | 12 | 88689454 | 90301709 | Mouse | 204 | description | gene, protein-coding, REVIEWED [RefSeq] |
| 1350531 | NTNG1 | netrin G1 | This gene encodes a preproprotein that is processed into a secreted protein containing eukaroytic growth factor (EGF)-like domains. This protein acts to guide axon growth during neuronal development. Polymorphisms in this gene may be associated with schizophreni a. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Aug 2015] | 1 | 107140088 | 107484923 | Human | 158 | description | gene, protein-coding, REVIEWED [RefSeq] |
| 1316469 | POFUT2 | protein O-fucosyltransferase 2 | Fucose is typically found as a terminal modification of branched chain glycoconjugates, but it also exists in direct O-linkage to serine or threonine residues within cystine knot motifs in epidermal growth factor (EGF; MIM 131530)-like repeats or thrombospondin (THBS; see MIM 188060) type-1 repeats. POFUT2 is an O-fucosyltransferase that use THBS type-1 repeats as substrates (Luo et al., 2006 [PubMed 16464857]).[supplied by OMIM, Mar 2008] | 21 | 45263935 | 45287895 | Human | 97 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 1332013 | Poglut1 | protein O-glucosyltransferase 1 | This gene encodes a protein that can catalyze transfer of either UDP-glucose or UDP-xylose to epidermal growth factor (EGF) repeats, such as those found in Notch. Loss of this gene product results in embryonic lethality. Embryos have neural plate defects, heart defects, and truncations of their posterior axis. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014] | 16 | 38345420 | 38370619 | Mouse | 158 | description | gene, protein-coding, REVIEWED [RefSeq] |
| 731722 | PPT2 | palmitoyl-protein thioesterase 2 | This gene encodes a member of the palmitoyl-protein thioesterase family. The encoded glycosylated lysosomal protein has palmitoyl-CoA hydrolase activity in vitro, but does not hydrolyze palmitate from cysteine residues in proteins. Alternative splicing results in multiple transcript variants. Read-t hrough transcription also exists between this gene and the downstream EGFL8 (EGF-like-domain, multiple 8) gene. [provided by RefSeq, Feb 2011] | 6 | 32153528 | 32163675 | Human | 73 | description | gene, protein-coding, REVIEWED [RefSeq] |
| 736831 | SELE | selectin E | The protein encoded by this gene is found in cytokine-stimulated endothelial cells and is thought to be responsible for the accumulation of blood leukocytes at sites of inflammation by mediating the adhesion of cells to the vascular lining. It exhibits structural features such as the presence of lec tin- and EGF-like domains followed by short consensus repeat (SCR) domains that contain 6 conserved cysteine residues. These proteins are part of the selectin family of cell adhesion molecules. Adhesion molecules participate in the interaction between leukocytes and the endothelium and appear to be involved in the pathogenesis of atherosclerosis. [provided by RefSeq, Jul 2008] | 1 | 169722640 | 169734079 | Human | 335 | description | gene, protein-coding, REVIEWED [RefSeq] |
| 732184 | STAT1 | signal transducer and activator of transcription 1 | The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription ac tivators. The protein encoded by this gene can be activated by various ligands including interferon-alpha, interferon-gamma, EGF, PDGF and IL6. This protein mediates the expression of a variety of genes, which is thought to be important for cell viability in response to different cell stimuli and pathogens. The protein plays an important role in immune responses to viral, fungal and mycobacterial pathogens. Mutations in this gene are associated with Immunodeficiency 31B, 31A, and 31C. [provided by RefSeq, Jun 2020] | 2 | 190969149 | 191014171 | Human | 999 | description | gene, protein-coding, REVIEWED [RefSeq] |
| 69005 | Stat3 | signal transducer and activator of transcription 3 | The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription ac tivators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Sep 2015] | 11 | 100777632 | 100830447 | Mouse | 1950 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 737517 | STAT3 | signal transducer and activator of transcription 3 | The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription ac tivators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein. This gene also plays a role in regulating host response to viral and bacterial infections. Mutations in this gene are associated with infantile-onset multisystem autoimmune disease and hyper-immunoglobulin E syndrome. [provided by RefSeq, Aug 2020] | 17 | 42313324 | 42388442 | Human | 2045 | description | gene, protein-coding, REVIEWED [RefSeq] |
| 1354144 | TNC | tenascin C | This gene encodes an extracellular matrix protein with a spatially and temporally restricted tissue distribution. This protein is homohexameric with disulfide-linked subunits, and contains multiple EGF-like and fibronectin type-III domains. It is implicated in g uidance of migrating neurons as well as axons during development, synaptic plasticity, and neuronal regeneration. [provided by RefSeq, Jul 2011] | 9 | 115019575 | 115118157 | Human | 428 | description | gene, protein-coding, REVIEWED [RefSeq] |
| 736503 | USH2A | usherin | This gene encodes a protein that contains laminin EGF motifs, a pentaxin domain, and many fibronectin type III motifs. The protein is found in the basement membrane, and may be important in development and homeostasis of the inner ear and retina. Mutations withi n this gene have been associated with Usher syndrome type IIa and retinitis pigmentosa. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2008] | 1 | 215622891 | 216423448 | Human | 3045 | description | gene, protein-coding, REVIEWED [RefSeq] |
| 731989 | WIF1 | Wnt inhibitory factor 1 | The protein encoded by this gene functions to inhibit WNT proteins, which are extracellular signaling molecules that play a role in embryonic development. This protein contains a WNT inhibitory factor (WIF) domain and five epidermal growth factor (EGF)-like doma ins, and is thought to be involved in mesoderm segmentation. This gene functions as a tumor suppressor gene, and has been found to be epigenetically silenced in various cancers. [provided by RefSeq, Jun 2010] | 12 | 65050626 | 65121305 | Human | 144 | description | gene, protein-coding, REVIEWED [RefSeq] |
| 620998 | Nell1 | neural EGFL like 1 | ENCODES a protein that exhibits heparin binding; identical protein binding; protein kinase C binding; INVOLVED IN positive regulation of apoptotic process; positive regulation of ossification; regulation of osteoblast differentiation; ASSOCIATED WITH abnormal craniofacial bone morphology; ASSOCIATED WITH craniosynostosis; esophagus adenocarcinoma (ortholog); prostate cancer (ortholog); FOUND IN extracellular space; cytoplasm (ortholog); nuclear envelope (ortholog); INTERACTS WITH 17alpha-ethynylestradiol; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine | 1 | 108845462 | 109709858 | Rat | 125 | name | gene, protein-coding, VALIDATED [RefSeq] |
| 8758810 | Nell1 | neural EGFL like 1 | ENCODES a protein that exhibits heparin binding (ortholog); identical protein binding (ortholog); protein kinase C binding (ortholog); INVOLVED IN negative regulation of osteoblast proliferation (ortholog); negative regulation of protein catabolic process (ortholog); positive regulation of apoptotic process (ortholog); ASSOCIATED WITH craniosynostosis (ortholog); esophagus adenocarcinoma (ortholog); prostate cancer (ortholog); FOUND IN cytoplasm (ortholog); extracellular space (ortholog); nuclear envelope (ortholog) | NW_004955476 | 1445234 | 2236954 | Chinchilla | 23 | name | gene, protein-coding, MODEL [RefSeq] |
| 11677418 | NELL1 | neural EGFL like 1 | ENCODES a protein that exhibits heparin binding (ortholog); identical protein binding (ortholog); protein kinase C binding (ortholog); INVOLVED IN positive regulation of apoptotic process (ortholog); positive regulation of ossification (ortholog); regulation of osteoblast differentiation (ortholog); ASSOCIATED WITH craniosynostosis (ortholog); esophagus adenocarcinoma (ortholog); prostate cancer (ortholog); FOUND IN extracellular space (ortholog) | 11 | 20697153 | 21600601 | Bonobo | 36 | name | gene, protein-coding, MODEL [RefSeq] |
| 12262187 | NELL1 | neural EGFL like 1 | ENCODES a protein that exhibits heparin binding (ortholog); identical protein binding (ortholog); protein kinase C binding (ortholog); INVOLVED IN negative regulation of osteoblast proliferation (ortholog); negative regulation of protein catabolic process (ortholog); positive regulation of apoptotic process (ortholog); ASSOCIATED WITH craniosynostosis (ortholog); esophagus adenocarcinoma (ortholog); prostate cancer (ortholog); FOUND IN cytoplasm (ortholog); extracellular space (ortholog); nuclear envelope (ortholog) | 21 | 42654925 | 43468806 | Dog | 30 | name | gene, protein-coding, MODEL [RefSeq] |
| 12681097 | Nell1 | neural EGFL like 1 | ENCODES a protein that exhibits heparin binding (ortholog); identical protein binding (ortholog); protein kinase C binding (ortholog); INVOLVED IN positive regulation of apoptotic process (ortholog); positive regulation of ossification (ortholog); regulation of osteoblast differentiation (ortholog); ASSOCIATED WITH craniosynostosis (ortholog); esophagus adenocarcinoma (ortholog); prostate cancer (ortholog); FOUND IN extracellular space (ortholog) | NW_004936654 | 1591016 | 2392496 | Squirrel | 37 | old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 13893103 | NELL1 | neural EGFL like 1 | ENCODES a protein that exhibits heparin binding (ortholog); identical protein binding (ortholog); protein kinase C binding (ortholog); INVOLVED IN positive regulation of apoptotic process (ortholog); positive regulation of ossification (ortholog); regulation of osteoblast differentiation (ortholog); ASSOCIATED WITH craniosynostosis (ortholog); esophagus adenocarcinoma (ortholog); prostate cancer (ortholog); FOUND IN extracellular space (ortholog) | | | | Pig | 37 | name | gene, protein-coding, MODEL [RefSeq] |
| 18636791 | NELL1 | neural EGFL like 1 | ENCODES a protein that exhibits heparin binding (ortholog); identical protein binding (ortholog); protein kinase C binding (ortholog); INVOLVED IN positive regulation of apoptotic process (ortholog); positive regulation of ossification (ortholog); regulation of osteoblast differentiation (ortholog); ASSOCIATED WITH craniosynostosis (ortholog); esophagus adenocarcinoma (ortholog); prostate cancer (ortholog); FOUND IN extracellular space (ortholog) | | | | Green Monkey | 36 | name | gene, protein-coding, MODEL [RefSeq] |
| 18909636 | Nell1 | neural EGFL like 1 | ENCODES a protein that exhibits heparin binding (ortholog); identical protein binding (ortholog); protein kinase C binding (ortholog); INVOLVED IN negative regulation of osteoblast proliferation (ortholog); negative regulation of protein catabolic process (ortholog); positive regulation of apoptotic process (ortholog); ASSOCIATED WITH craniosynostosis (ortholog); esophagus adenocarcinoma (ortholog); prostate cancer (ortholog); FOUND IN extracellular space (ortholog); nuclear envelope (ortholog); perinuclear region of cytoplasm (ortholog) | | | | Naked Mole-Rat | 31 | name | gene, protein-coding, MODEL [RefSeq] |
| 620999 | Nell2 | neural EGFL like 2 | ENCODES a protein that exhibits heparin binding; identical protein binding; protein kinase C binding; INVOLVED IN development of secondary female sexual characteristics; neurogenesis; neuron cellular homeostasis; ASSOCIATED WITH lung adenocarcinoma (ortholog); FOUND IN cytoplasm; dendrite; extracell ular space; INTERACTS WITH 17beta-estradiol; 17beta-estradiol 3-benzoate; 2,3,7,8-tetrachlorodibenzodioxine | 7 | 128222333 | 128542127 | Rat | 142 | name | gene, protein-coding, VALIDATED [RefSeq] |
| 8862144 | Nell2 | neural EGFL like 2 | ENCODES a protein that exhibits calcium ion binding (ortholog); heparin binding (ortholog); identical protein binding (ortholog); INVOLVED IN commissural neuron axon guidance (ortholog); development of secondary female sexual characteristics (ortholog); fertilization (ortholog); ASSOCIATED WITH lung adenocarcinoma (ortholog); FOUND IN cytoplasm (ortholog); dendrite (ortholog); extracellular region (ortholog) | NW_004955500 | 3669893 | 4049765 | Chinchilla | 28 | name | gene, protein-coding, MODEL [RefSeq] |
| 11963866 | NELL2 | neural EGFL like 2 | ENCODES a protein that exhibits heparin binding (ortholog); identical protein binding (ortholog); protein kinase C binding (ortholog); INVOLVED IN development of secondary female sexual characteristics (ortholog); neurogenesis (ortholog); neuron cellular homeostasis (ortholog); ASSOCIATED WITH lung adenocarcinoma (ortholog); FOUND IN dendrite (ortholog); extracellular space (ortholog); perikaryon (ortholog) | 12 | 43820215 | 44226249 | Bonobo | 29 | name | gene, protein-coding, MODEL [RefSeq] |
| 12209092 | NELL2 | neural EGFL like 2 | ENCODES a protein that exhibits heparin binding (ortholog); identical protein binding (ortholog); protein kinase C binding (ortholog); INVOLVED IN development of secondary female sexual characteristics (ortholog); neurogenesis (ortholog); neuron cellular homeostasis (ortholog); ASSOCIATED WITH lung adenocarcinoma (ortholog); FOUND IN cytoplasm (ortholog); dendrite (ortholog); extracellular space (ortholog) | 27 | 9300001 | 9680974 | Dog | 31 | name | gene, protein-coding, MODEL [RefSeq] |
| 12581997 | Nell2 | neural EGFL like 2 | ENCODES a protein that exhibits heparin binding (ortholog); identical protein binding (ortholog); protein kinase C binding (ortholog); INVOLVED IN development of secondary female sexual characteristics (ortholog); neurogenesis (ortholog); neuron cellular homeostasis (ortholog); ASSOCIATED WITH lung adenocarcinoma (ortholog); FOUND IN dendrite (ortholog); extracellular space (ortholog); perikaryon (ortholog) | NW_004936512 | 2862823 | 3225350 | Squirrel | 30 | name | gene, protein-coding, MODEL [RefSeq] |
| 14037010 | NELL2 | neural EGFL like 2 | ENCODES a protein that exhibits heparin binding (ortholog); identical protein binding (ortholog); protein kinase C binding (ortholog); INVOLVED IN development of secondary female sexual characteristics (ortholog); neurogenesis (ortholog); neuron cellular homeostasis (ortholog); ASSOCIATED WITH lung adenocarcinoma (ortholog); FOUND IN cytoplasm (ortholog); dendrite (ortholog); extracellular space (ortholog) | | | | Pig | 31 | name | gene, protein-coding, MODEL [RefSeq] |
| 18707435 | NELL2 | neural EGFL like 2 | ENCODES a protein that exhibits heparin binding (ortholog); identical protein binding (ortholog); protein kinase C binding (ortholog); INVOLVED IN development of secondary female sexual characteristics (ortholog); neurogenesis (ortholog); neuron cellular homeostasis (ortholog); ASSOCIATED WITH lung adenocarcinoma (ortholog); FOUND IN dendrite (ortholog); extracellular space (ortholog); perikaryon (ortholog) | | | | Green Monkey | 29 | name | gene, protein-coding, MODEL [RefSeq] |
| 18924276 | Nell2 | neural EGFL like 2 | ENCODES a protein that exhibits heparin binding (ortholog); identical protein binding (ortholog); protein kinase C binding (ortholog); INVOLVED IN commissural neuron axon guidance (ortholog); development of secondary female sexual characteristics (ortholog); fertilization (ortholog); ASSOCIATED WITH lung adenocarcinoma (ortholog); FOUND IN dendrite (ortholog); extracellular region (ortholog); extracellular space (ortholog) | | | | Naked Mole-Rat | 30 | name | gene, protein-coding, MODEL [RefSeq] |
| 626053600 | Nell2 | neural EGFL like 2 | ENCODES a protein that exhibits calcium ion binding (ortholog); heparin binding (ortholog); identical protein binding (ortholog); INVOLVED IN commissural neuron axon guidance (ortholog); development of secondary female sexual characteristics (ortholog); fertilization (ortholog); ASSOCIATED WITH lung adenocarcinoma (ortholog); FOUND IN cytoplasm (ortholog); dendrite (ortholog); extracellular region (ortholog) | | | | Black Rat | 28 | name | gene, protein-coding, MODEL [RefSeq] |
| 1614315 | Eldr | Egfr long non-coding downstream RNA | Acts upstream of or within regulation of gene expression and response to wounding. Is expressed in brain; cortical layer VI; neocortex; telencephalon mantle layer; and telencephalon ventricular layer. Orthologous to human ELDR (EGFR long non-coding downstream RN A). [provided by Alliance of Genome Resources, Jul 2025] | 11 | 16884709 | 16901282 | Mouse | 9 | name , description | gene, ncrna, VALIDATED [RefSeq] |
| 8162430 | ELDR | EGFR long non-coding downstream RNA | Predicted to act upstream of or within regulation of gene expression and response to wounding. [provided by Alliance of Genome Resources, Jul 2025] | 7 | 55238436 | 55255635 | Human | 8 | name | gene, ncrna, VALIDATED [RefSeq] |
| 1310590 | Eps8 | EGFR pathway substrate 8, signaling adaptor | ENCODES a protein that exhibits actin binding (ortholog); small GTPase binding (ortholog); INVOLVED IN actin crosslink formation (ortholog); actin cytoskeleton organization (ortholog); actin filament bundle assembly (ortholog); PARTICIPATES IN platelet-derived growth factor signaling pathway; ASSOCI ATED WITH autosomal recessive nonsyndromic deafness (ortholog); autosomal recessive nonsyndromic deafness 102 (ortholog); autosomal recessive nonsyndromic deafness 106 (ortholog); FOUND IN glutamatergic synapse; postsynaptic density; brush border (ortholog); INTERACTS WITH 2,2',4,4'-Tetrabromodiphenyl ether; 2,3,7,8-tetrachlorodibenzodioxine; 3,3',4,4',5-pentachlorobiphenyl | 4 | 172119497 | 172291670 | Rat | 232 | name | gene, protein-coding, VALIDATED [RefSeq] |
| 1321587 | EPS8 | EGFR pathway substrate 8, signaling adaptor | This gene encodes a member of the EPS8 family. This protein contains one PH domain and one SH3 domain. It functions as part of the EGFR pathway, though its exact role has not been determined. Highly similar proteins in other organisms are involved in the transdu ction of signals from Ras to Rac and growth factor-mediated actin remodeling. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized. [provided by RefSeq, Jul 2008] | 12 | 15620134 | 15789388 | Human | 242 | name , description | gene, protein-coding, REVIEWED [RefSeq] |
| 8833527 | Eps8 | EGFR pathway substrate 8, signaling adaptor | ENCODES a protein that exhibits actin binding (ortholog); small GTPase binding (ortholog); INVOLVED IN actin crosslink formation (ortholog); actin cytoskeleton organization (ortholog); actin filament bundle assembly (ortholog); PARTICIPATES IN platelet-derived growth factor signaling pathway; ASSOCI ATED WITH autosomal recessive nonsyndromic deafness (ortholog); autosomal recessive nonsyndromic deafness 102 (ortholog); autosomal recessive nonsyndromic deafness 106 (ortholog); FOUND IN brush border (ortholog); cell cortex (ortholog); glutamatergic synapse (ortholog) | NW_004955413 | 12267701 | 12386088 | Chinchilla | 61 | name | gene, protein-coding, MODEL [RefSeq] |
| 11784910 | EPS8 | EGFR pathway substrate 8, signaling adaptor | ENCODES a protein that exhibits actin binding (inferred); small GTPase binding (inferred); INVOLVED IN actin cytoskeleton organization (ortholog); actin filament bundle assembly (ortholog); adult locomotory behavior (ortholog); PARTICIPATES IN platelet-derived growth factor signaling pathway; ASSOCI ATED WITH autosomal recessive nonsyndromic deafness (ortholog); autosomal recessive nonsyndromic deafness 102 (ortholog); autosomal recessive nonsyndromic deafness 106 (ortholog); FOUND IN postsynaptic density (ortholog) | 12 | 15617536 | 15788537 | Bonobo | 77 | name | gene, protein-coding, MODEL [RefSeq] |
| 12122223 | EPS8 | EGFR pathway substrate 8, signaling adaptor | ENCODES a protein that exhibits actin binding (inferred); small GTPase binding (inferred); INVOLVED IN actin cytoskeleton organization (ortholog); actin filament bundle assembly (ortholog); adult locomotory behavior (ortholog); PARTICIPATES IN platelet-derived growth factor signaling pathway; ASSOCI ATED WITH autosomal recessive nonsyndromic deafness (ortholog); autosomal recessive nonsyndromic deafness 102 (ortholog); autosomal recessive nonsyndromic deafness 106 (ortholog); FOUND IN postsynaptic density (ortholog) | 27 | 30893884 | 31070401 | Dog | 72 | name | gene, protein-coding, MODEL [RefSeq] |
| 12700697 | Eps8 | EGFR pathway substrate 8, signaling adaptor | ENCODES a protein that exhibits actin binding (inferred); small GTPase binding (inferred); INVOLVED IN actin cytoskeleton organization (ortholog); actin filament bundle assembly (ortholog); adult locomotory behavior (ortholog); PARTICIPATES IN platelet-derived growth factor signaling pathway; ASSOCI ATED WITH autosomal recessive nonsyndromic deafness (ortholog); autosomal recessive nonsyndromic deafness 102 (ortholog); autosomal recessive nonsyndromic deafness 106 (ortholog); FOUND IN postsynaptic density (ortholog) | NW_004936587 | 1785721 | 1951474 | Squirrel | 73 | name | gene, protein-coding, MODEL [RefSeq] |
| 14124718 | EPS8 | EGFR pathway substrate 8, signaling adaptor | ENCODES a protein that exhibits actin binding (inferred); kinase activity (inferred); small GTPase binding (inferred); INVOLVED IN actin cytoskeleton organization (ortholog); actin filament bundle assembly (ortholog); adult locomotory behavior (ortholog); PARTICIPATES IN platelet-derived growth fact or signaling pathway; ASSOCIATED WITH autosomal recessive nonsyndromic deafness (ortholog); autosomal recessive nonsyndromic deafness 102 (ortholog); autosomal recessive nonsyndromic deafness 106 (ortholog); FOUND IN postsynaptic density (ortholog) | | | | Pig | 74 | name | gene, protein-coding, MODEL [RefSeq] |
| 18574690 | EPS8 | EGFR pathway substrate 8, signaling adaptor | ENCODES a protein that exhibits actin binding (inferred); small GTPase binding (inferred); INVOLVED IN actin cytoskeleton organization (ortholog); actin filament bundle assembly (ortholog); adult locomotory behavior (ortholog); PARTICIPATES IN platelet-derived growth factor signaling pathway; ASSOCI ATED WITH autosomal recessive nonsyndromic deafness (ortholog); autosomal recessive nonsyndromic deafness 102 (ortholog); autosomal recessive nonsyndromic deafness 106 (ortholog); FOUND IN postsynaptic density (ortholog) | | | | Green Monkey | 77 | name | gene, protein-coding, MODEL [RefSeq] |
| 18935934 | Eps8 | EGFR pathway substrate 8, signaling adaptor | ENCODES a protein that exhibits small GTPase binding (ortholog); INVOLVED IN actin crosslink formation (ortholog); actin cytoskeleton organization (ortholog); actin filament bundle assembly (ortholog); PARTICIPATES IN platelet-derived growth factor signaling pathway; ASSOCIATED WITH autosomal recess ive nonsyndromic deafness (ortholog); autosomal recessive nonsyndromic deafness 102 (ortholog); autosomal recessive nonsyndromic deafness 106 (ortholog); FOUND IN brush border (ortholog); glutamatergic synapse (ortholog); NMDA selective glutamate receptor complex (ortholog) | | | | Naked Mole-Rat | 73 | name | gene, protein-coding, MODEL [RefSeq] |
| 625891761 | Eps8 | EGFR pathway substrate 8, signaling adaptor | ENCODES a protein that exhibits actin binding (ortholog); small GTPase binding (ortholog); INVOLVED IN actin crosslink formation (ortholog); actin cytoskeleton organization (ortholog); actin filament bundle assembly (ortholog); PARTICIPATES IN platelet-derived growth factor signaling pathway; ASSOCI ATED WITH autosomal recessive nonsyndromic deafness (ortholog); autosomal recessive nonsyndromic deafness 102 (ortholog); autosomal recessive nonsyndromic deafness 106 (ortholog); FOUND IN brush border (ortholog); cell cortex (ortholog); glutamatergic synapse (ortholog) | | | | Black Rat | 61 | name | gene, protein-coding, MODEL [RefSeq] |
| 16552877 | EUDAL | EGFR ubiquitination and degradation associated lncRNA | | | | | Human | | name | gene, lncrna |
| 629021557 | EUDAL | EGFR ubiquitination and degradation associated lncRNA | | | | | Human | | name | gene, ncrna |
| 16552643 | AC241585.1 | EGFR-coamplified and overexpressed protein (ECOP) pseudogene | | | | | Human | | name | gene, processed_pseudogene |
| 1605377 | KLHDC8A | kelch domain containing 8A | This gene encodes a kelch domain-containing protein which is upregulated in cancer. Upregulated expression of the encoded protein may provide an alternative pathway for tumors to maintain aggressiveness in the absence of epidermal growth factor receptor dependence. Alternative splicing results in mu ltiple transcript variants. [provided by RefSeq, Dec 2012] | 1 | 205336061 | 205357039 | Human | 77 | old_gene_name | gene, protein-coding, REVIEWED [RefSeq] |
| 1306494 | Vopp1 | VOPP1 WW domain binding protein | ENCODES a protein that exhibits enzyme binding (ortholog); protein sequestering activity (ortholog); INVOLVED IN DNA-templated transcription (inferred); ASSOCIATED WITH acute myeloid leukemia (ortholog); Experimental Liver Cirrhosis (ortholog); FOUND IN cytoplasmic vesicle membrane (ortholog); endos ome (ortholog); late endosome (ortholog); INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 4,4'-diaminodiphenylmethane | 4 | 88692784 | 88762903 | Rat | 95 | old_gene_name | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1315143 | Vopp1 | vesicular, overexpressed in cancer, prosurvival protein 1 | Predicted to enable enzyme binding activity. Predicted to be located in cytoplasmic vesicle membrane; late endosome; and lysosome. Predicted to be active in organelle membrane. Is expressed in several structures, including alimentary system; cardiovascular system; central nervous system; genitourina ry system; and neural retina. Orthologous to human VOPP1 (VOPP1 WW domain binding protein). [provided by Alliance of Genome Resources, Jul 2025] | 6 | 57729249 | 57802110 | Mouse | 106 | old_gene_name | gene, protein-coding, VALIDATED [RefSeq] |
| 1602094 | VOPP1 | VOPP1 WW domain binding protein | Enables enzyme binding activity. Located in cytoplasmic vesicle membrane; late endosome; and lysosome. [provided by Alliance of Genome Resources, Jul 2025] | 7 | 55434964 | 55572502 | Human | 95 | old_gene_name | gene, protein-coding, VALIDATED [RefSeq] |
| 9059226 | Btc | betacellulin | ENCODES a protein that exhibits epidermal growth factor receptor binding (ortholog); growth factor activity (ortholog); receptor ligand activity (ortholog); INVOLVED IN epidermal growth factor receptor signaling pathway (ortholog); ERBB2-EGFR signaling pathway ( ortholog); ERBB4-ERBB4 signaling pathway (ortholog); PARTICIPATES IN epidermal growth factor/neuregulin signaling pathway; ASSOCIATED WITH erythropoietic protoporphyria (ortholog); Experimental Diabetes Mellitus (ortholog); Glucagonoma (ortholog); FOUND IN extracellular space (ortholog) | NW_004955474 | 895573 | 946152 | Chinchilla | 39 | description | gene, protein-coding, MODEL [RefSeq] |
| 12310144 | BTC | betacellulin | ENCODES a protein that exhibits epidermal growth factor receptor binding (ortholog); growth factor activity (ortholog); INVOLVED IN epidermal growth factor receptor signaling pathway (ortholog); ERBB2-EGFR signaling pathway (ortholog); ERBB4-ERBB4 signaling path way (ortholog); PARTICIPATES IN epidermal growth factor/neuregulin signaling pathway; ASSOCIATED WITH erythropoietic protoporphyria (ortholog); Experimental Diabetes Mellitus (ortholog); Glucagonoma (ortholog); FOUND IN extracellular region (inferred); extracellular space (inferred); plasma membrane (inferred) | 15 | 64133051 | 64159155 | Dog | 43 | description | gene, protein-coding, MODEL [RefSeq] |
| 18903782 | Btc | betacellulin | ENCODES a protein that exhibits epidermal growth factor receptor binding (ortholog); growth factor activity (ortholog); INVOLVED IN epidermal growth factor receptor signaling pathway (ortholog); ERBB2-EGFR signaling pathway (ortholog); ERBB4-ERBB4 signaling path way (ortholog); PARTICIPATES IN epidermal growth factor/neuregulin signaling pathway; ASSOCIATED WITH erythropoietic protoporphyria (ortholog); Experimental Diabetes Mellitus (ortholog); Glucagonoma (ortholog); FOUND IN extracellular space (ortholog) | | | | Naked Mole-Rat | 45 | description | gene, protein-coding, MODEL [RefSeq] |
| 1321588 | Eps8 | epidermal growth factor receptor pathway substrate 8 | Enables actin binding activity and small GTPase binding activity. Involved in several processes, including Rac protein signal transduction; actin filament organization; and barbed-end actin filament capping. Acts upstream of or within several processes, including adult locomotory behavior; behaviora l response to ethanol; and cellular response to leukemia inhibitory factor. Located in several cellular components, including brush border; ruffle membrane; and stereocilium tip. Part of NMDA selective glutamate receptor complex. Is active in glutamatergic synapse. Is expressed in several structures, including adrenal gland; alimentary system; bone; brain; and metanephros. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 102. Orthologous to human EPS8 (EGFR pathway substrate 8, signaling adaptor). [provided by Alliance of Genome Resources, Jul 2025] | 6 | 137454242 | 137626262 | Mouse | 222 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 11962137 | EREG | epiregulin | ENCODES a protein that exhibits growth factor activity (ortholog); INVOLVED IN epidermal growth factor receptor signaling pathway (ortholog); ERBB2-EGFR signaling pathway (ortholog); ERBB2-ERBB4 signaling pathway (ortholog); PARTICIPATES IN epidermal growth fact or/neuregulin signaling pathway; ASSOCIATED WITH cholesteatoma (ortholog); erythropoietic protoporphyria (ortholog); Experimental Colitis (ortholog); FOUND IN extracellular space (ortholog) | 4 | 49806505 | 49827961 | Bonobo | 74 | description | gene, protein-coding, MODEL [RefSeq] |
| 12141175 | EREG | epiregulin | ENCODES a protein that exhibits growth factor activity (ortholog); INVOLVED IN epidermal growth factor receptor signaling pathway (ortholog); ERBB2-EGFR signaling pathway (ortholog); ERBB2-ERBB4 signaling pathway (ortholog); PARTICIPATES IN epidermal growth fact or/neuregulin signaling pathway; ASSOCIATED WITH cholesteatoma (ortholog); erythropoietic protoporphyria (ortholog); Experimental Colitis (ortholog); FOUND IN extracellular space (ortholog); INTERACTS WITH bisphenol A | 13 | 62857325 | 62877831 | Dog | 73 | description | gene, protein-coding, MODEL [RefSeq] |
| 12504983 | Ereg | epiregulin | ENCODES a protein that exhibits growth factor activity (ortholog); INVOLVED IN epidermal growth factor receptor signaling pathway (ortholog); ERBB2-EGFR signaling pathway (ortholog); ERBB2-ERBB4 signaling pathway (ortholog); PARTICIPATES IN epidermal growth fact or/neuregulin signaling pathway; ASSOCIATED WITH cholesteatoma (ortholog); erythropoietic protoporphyria (ortholog); Experimental Colitis (ortholog); FOUND IN extracellular space (ortholog) | NW_004936598 | 1328803 | 1336141 | Squirrel | 75 | description | gene, protein-coding, MODEL [RefSeq] |
| 14027555 | EREG | epiregulin | ENCODES a protein that exhibits growth factor activity (ortholog); INVOLVED IN epidermal growth factor receptor signaling pathway (ortholog); ERBB2-EGFR signaling pathway (ortholog); ERBB2-ERBB4 signaling pathway (ortholog); PARTICIPATES IN epidermal growth fact or/neuregulin signaling pathway; ASSOCIATED WITH cholesteatoma (ortholog); erythropoietic protoporphyria (ortholog); Experimental Colitis (ortholog); FOUND IN extracellular space (ortholog); INTERACTS WITH deoxynivalenol | | | | Pig | 73 | description | gene, protein-coding, MODEL [RefSeq] |
| 18571345 | EREG | epiregulin | ENCODES a protein that exhibits growth factor activity (ortholog); INVOLVED IN epidermal growth factor receptor signaling pathway (ortholog); ERBB2-EGFR signaling pathway (ortholog); ERBB2-ERBB4 signaling pathway (ortholog); PARTICIPATES IN epidermal growth fact or/neuregulin signaling pathway; ASSOCIATED WITH cholesteatoma (ortholog); erythropoietic protoporphyria (ortholog); Experimental Colitis (ortholog); FOUND IN extracellular space (ortholog) | | | | Green Monkey | 74 | description | gene, protein-coding, MODEL [RefSeq] |
| 625813034 | Fmr1em1Sidb | FMRP translational regulator 1; ZFN induced mutant1,Sidb | ASSOCIATED WITH abnormal afterhyperpolarization; abnormal brain wave pattern; abnormal habituation to a new environment; ASSOCIATED WITH fragile X syndrome | | | | Rat | 10 | description | gene, allele |
| 733273 | GRB7 | growth factor receptor bound protein 7 | The product of this gene belongs to a small family of adapter proteins that are known to interact with a number of receptor tyrosine kinases and signaling molecules. This gene encodes a growth factor receptor-binding protein that interacts with epidermal growth factor receptor (EGF ght:700;'>EGFR) and ephrin receptors. The protein plays a role in the integrin signaling pathway and cell migration by binding with focal adhesion kinase (FAK). Several transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jun 2011] | 17 | 39737938 | 39747285 | Human | 164 | description | gene, protein-coding, REVIEWED [RefSeq] |
| 1621212 | Nell1 | NEL-like 1 | Predicted to enable heparin binding activity; identical protein binding activity; and protein kinase C binding activity. Predicted to be involved in several processes, including negative regulation of osteoblast proliferation; positive regulation of bone mineralization; and positive regulation of os teoblast differentiation. Predicted to be located in nuclear envelope and perinuclear region of cytoplasm. Predicted to be active in cytoplasm and extracellular space. Is expressed in several structures, including basal columns; chondrocranium; tooth; tooth bud; and urinary system. Orthologous to human NELL1 (neural EGFL like 1). [provided by Alliance of Genome Resources, Jul 2025] | 7 | 49625098 | 50513037 | Mouse | 176 | description | gene, protein-coding, PROVISIONAL [RefSeq] |
| 732317 | Nell2 | NEL-like 2 | Enables identical protein binding activity. Involved in commissural neuron axon guidance and fertilization. Located in extracellular region. Is expressed in several structures, including alimentary system; autopod; central nervous system; limb mesenchyme; and sensory organ. Orthologous to human NELL 2 (neural EGFL like 2). [provided by Alliance of Genome Resources, Jul 2025] | 15 | 95117321 | 95426677 | Mouse | 152 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 1606150 | NRG4 | neuregulin 4 | The neuregulins, including NRG4, activate type-1 growth factor receptors (see EGFR; MIM 131550) to initiating cell-to-cell signaling through tyrosine phosphorylation (Harari et al., 1999 [PubMed 10348342]).[supplied by OMIM, Mar 2008] | 15 | 75935393 | 76060240 | Human | 88 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 1347457 | RAB11FIP1 | RAB11 family interacting protein 1 | This gene encodes one of the Rab11-family interacting proteins (Rab11-FIPs), which play a role in the Rab-11 mediated recycling of vesicles. The encoded protein may be involved in endocytic sorting, trafficking of proteins including integrin subunits and epidermal growth factor receptor (EGF ='font-weight:700;'>EGFR), and transport between the recycling endosome and the trans-Golgi network. Alternative splicing results in multiple transcript variants. A pseudogene is described on the X chromosome. [provided by RefSeq, Dec 2013] | 8 | 37858618 | 37899497 | Human | 109 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 1605862 | SH3D19 | SH3 domain containing 19 | This gene encodes a multiple SH3 domain-containing protein, which interacts with other proteins, such as EBP and members of ADAM family, via the SH3 domains. This protein may be involved in suppression of Ras-induced cellular transformation and Ras-mediated activation of ELK1 by EBP, and regulation of ADAM proteins in the signaling of EGFR-ligand shedding. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011] | 4 | 151120281 | 151325605 | Human | 110 | description | gene, protein-coding, REVIEWED [RefSeq] |
| 620446 | Shc1 | SHC adaptor protein 1 | ENCODES a protein that exhibits epidermal growth factor receptor binding; phosphoprotein binding; phosphotyrosine residue binding; INVOLVED IN actin cytoskeleton organization; animal organ regeneration; cellular response to hydrogen peroxide; PARTICIPATES IN mitogen activated protein kinase signalin g pathway; the extracellular signal-regulated Raf/Mek/Erk signaling pathway; brain-derived neurotrophic factor signaling pathway; ASSOCIATED WITH decreased tubuloglomerular feedback response; decreased urine albumin level; glomerulosclerosis; ASSOCIATED WITH Albuminuria; Chronic Hepatitis; familial hyperlipidemia; FOUND IN endosome membrane; Shc-EGFR complex; cytosol (ortholog); INTERACTS WITH (+)-schisandrin B; (R)-noradrenaline; 17beta-estradiol | 2 | 177135649 | 177147257 | Rat | 363 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 1551749 | Shc1 | src homology 2 domain-containing transforming protein C1 | Enables epidermal growth factor binding activity; identical protein binding activity; and signaling receptor binding activity. Involved in insulin-like growth factor receptor signaling pathway. Acts upstream of or within several processes, including circulatory system development; epidermal growth f actor receptor signaling pathway; and positive regulation of MAPK cascade. Predicted to be located in endosome membrane. Predicted to be part of Shc-EGFR complex. Predicted to be active in plasma membrane. Is expressed in several structures, including cerebral cortex; early conceptus; liver; skeleton; and skin. Orthologous to human SHC1 (SHC adaptor protein 1). [provided by Alliance of Genome Resources, Jul 2025] | 3 | 89325858 | 89337336 | Mouse | 426 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 11873345 | SHC1 | SHC adaptor protein 1 | ENCODES a protein that exhibits epidermal growth factor receptor binding (ortholog); identical protein binding (ortholog); phosphoprotein binding (ortholog); INVOLVED IN actin cytoskeleton organization (ortholog); angiogenesis (ortholog); animal organ regeneration (ortholog); PARTICIPATES IN brain-d erived neurotrophic factor signaling pathway; epidermal growth factor/neuregulin signaling pathway; erythropoietin signaling pathway; ASSOCIATED WITH Albuminuria (ortholog); Alzheimer's disease (ortholog); amyotrophic lateral sclerosis type 1 (ortholog); FOUND IN endosome membrane (ortholog); Shc-EGFR complex (ortholog) | 1 | 130310778 | 130323001 | Bonobo | 152 | description | gene, protein-coding, MODEL [RefSeq] |
| 12338110 | SHC1 | SHC adaptor protein 1 | ENCODES a protein that exhibits epidermal growth factor receptor binding (ortholog); identical protein binding (ortholog); phosphoprotein binding (ortholog); INVOLVED IN actin cytoskeleton organization (ortholog); angiogenesis (ortholog); animal organ regeneration (ortholog); PARTICIPATES IN brain-d erived neurotrophic factor signaling pathway; epidermal growth factor/neuregulin signaling pathway; erythropoietin signaling pathway; ASSOCIATED WITH Albuminuria (ortholog); Alzheimer's disease (ortholog); amyotrophic lateral sclerosis type 1 (ortholog); FOUND IN endosome membrane (ortholog); Shc-EGFR complex (ortholog) | 7 | 42501829 | 42509613 | Dog | 150 | description | gene, protein-coding, MODEL [RefSeq] |
| 12687229 | Shc1 | SHC adaptor protein 1 | ENCODES a protein that exhibits epidermal growth factor receptor binding (ortholog); identical protein binding (ortholog); phosphoprotein binding (ortholog); INVOLVED IN actin cytoskeleton organization (ortholog); angiogenesis (ortholog); animal organ regeneration (ortholog); PARTICIPATES IN brain-d erived neurotrophic factor signaling pathway; epidermal growth factor/neuregulin signaling pathway; erythropoietin signaling pathway; ASSOCIATED WITH Albuminuria (ortholog); Alzheimer's disease (ortholog); amyotrophic lateral sclerosis type 1 (ortholog); FOUND IN endosome membrane (ortholog); Shc-EGFR complex (ortholog) | NW_004936580 | 4511560 | 4522003 | Squirrel | 152 | description | gene, protein-coding, MODEL [RefSeq] |
| 14007791 | SHC1 | SHC adaptor protein 1 | ENCODES a protein that exhibits epidermal growth factor receptor binding (ortholog); identical protein binding (ortholog); phosphoprotein binding (ortholog); INVOLVED IN actin cytoskeleton organization (ortholog); angiogenesis (ortholog); animal organ regeneration (ortholog); PARTICIPATES IN brain-d erived neurotrophic factor signaling pathway; epidermal growth factor/neuregulin signaling pathway; erythropoietin signaling pathway; ASSOCIATED WITH Albuminuria (ortholog); Alzheimer's disease (ortholog); amyotrophic lateral sclerosis type 1 (ortholog); FOUND IN endosome membrane (ortholog); Shc-EGFR complex (ortholog) | | | | Pig | 150 | description | gene, protein-coding, MODEL [RefSeq] |
| 18372060 | SHC1 | SHC adaptor protein 1 | ENCODES a protein that exhibits epidermal growth factor receptor binding (ortholog); identical protein binding (ortholog); phosphoprotein binding (ortholog); INVOLVED IN actin cytoskeleton organization (ortholog); angiogenesis (ortholog); animal organ regeneration (ortholog); PARTICIPATES IN brain-d erived neurotrophic factor signaling pathway; epidermal growth factor/neuregulin signaling pathway; erythropoietin signaling pathway; ASSOCIATED WITH Albuminuria (ortholog); Alzheimer's disease (ortholog); amyotrophic lateral sclerosis type 1 (ortholog); FOUND IN endosome membrane (ortholog); Shc-EGFR complex (ortholog) | | | | Green Monkey | 152 | description | gene, protein-coding, MODEL [RefSeq] |
| 18903816 | Shc1 | SHC adaptor protein 1 | ENCODES a protein that exhibits ephrin receptor binding (ortholog); epidermal growth factor binding (ortholog); epidermal growth factor receptor binding (ortholog); INVOLVED IN actin cytoskeleton organization (ortholog); angiogenesis (ortholog); animal organ regeneration (ortholog); PARTICIPATES IN brain-derived neurotrophic factor signaling pathway; epidermal growth factor/neuregulin signaling pathway; erythropoietin signaling pathway; ASSOCIATED WITH Albuminuria (ortholog); Alzheimer's disease (ortholog); amyotrophic lateral sclerosis type 1 (ortholog); FOUND IN cytosol (ortholog); endosome membrane (ortholog); Shc-EGFR complex (ortholog) | | | | Naked Mole-Rat | 152 | description | gene, protein-coding, MODEL [RefSeq] |
| 1603723 | SPINK9 | serine peptidase inhibitor Kazal type 9 | The protein encoded by this gene is a Kazal-type serine protease inhibitor that appears to specifically target kallikrein-related peptidase 5 (KLK5) in the palmo-plantar epidermis. KLK5 is an important initiator of skin desquamation, so the encoded protease inhibitor may regulate skin differentiatio n in the palms of hands and soles of feet. This cationic protein has also been shown to promote keratinocyte migration by activation of the epidermal growth factor receptor (EGFR). [provided by RefSeq, Dec 2015] | 5 | 148321305 | 148339852 | Human | 18 | description | gene, protein-coding, REVIEWED [RefSeq] |
| 11826938 | TGFA | transforming growth factor alpha | ENCODES a protein that exhibits epidermal growth factor receptor binding (ortholog); INVOLVED IN angiogenesis (ortholog); epidermal growth factor receptor signaling pathway (ortholog); ERBB2-EGFR signaling pathway (ortholog); PARTICIPATES IN altered epidermal gr owth factor/neuregulin signaling pathway; epidermal growth factor/neuregulin signaling pathway; pancreatic cancer pathway; ASSOCIATED WITH acute kidney failure (ortholog); Animal Mammary Neoplasms (ortholog); Experimental Liver Neoplasms (ortholog); FOUND IN extracellular space (ortholog) | 2A | 70510727 | 70617628 | Bonobo | 84 | description | gene, protein-coding, MODEL [RefSeq] |
| 12516463 | Tgfa | transforming growth factor alpha | ENCODES a protein that exhibits epidermal growth factor receptor binding (ortholog); INVOLVED IN angiogenesis (ortholog); epidermal growth factor receptor signaling pathway (ortholog); ERBB2-EGFR signaling pathway (ortholog); PARTICIPATES IN altered epidermal gr owth factor/neuregulin signaling pathway; epidermal growth factor/neuregulin signaling pathway; pancreatic cancer pathway; ASSOCIATED WITH acute kidney failure (ortholog); Animal Mammary Neoplasms (ortholog); Experimental Liver Neoplasms (ortholog); FOUND IN extracellular space (ortholog) | NW_004936491 | 14659089 | 14758614 | Squirrel | 85 | description | gene, protein-coding, MODEL [RefSeq] |
| 18533950 | TGFA | transforming growth factor alpha | ENCODES a protein that exhibits epidermal growth factor receptor binding (ortholog); INVOLVED IN angiogenesis (ortholog); epidermal growth factor receptor signaling pathway (ortholog); ERBB2-EGFR signaling pathway (ortholog); PARTICIPATES IN altered epidermal gr owth factor/neuregulin signaling pathway; epidermal growth factor/neuregulin signaling pathway; pancreatic cancer pathway; ASSOCIATED WITH acute kidney failure (ortholog); Animal Mammary Neoplasms (ortholog); Experimental Liver Neoplasms (ortholog); FOUND IN extracellular space (ortholog) | | | | Green Monkey | 84 | description | gene, protein-coding, MODEL [RefSeq] |
| 1605914 | UBASH3B | ubiquitin associated and SH3 domain containing B | This gene encodes a protein that contains a ubiquitin associated domain at the N-terminus, an SH3 domain, and a C-terminal domain with similarities to the catalytic motif of phosphoglycerate mutase. The encoded protein was found to inhibit endocytosis of epidermal growth factor receptor (EGF ='font-weight:700;'>EGFR) and platelet-derived growth factor receptor. [provided by RefSeq, Jul 2008] | 11 | 122655722 | 122814473 | Human | 151 | description | gene, protein-coding, VALIDATED [RefSeq] |
