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Gene: Btc (betacellulin, epidermal growth factor family member) Mus musculus
Symbol: Btc
Name: betacellulin, epidermal growth factor family member
Description: This gene encodes a member of the epidermal growth factor (EGF) family. These growth factors are ligands for the EGFR/ErbB receptor tyrosine kinases, and play roles in cell growth and differentiation. The encoded protein is synthesized as a transmembrane precursor that is proteolytically cleaved to generate a mature peptide, and plays a role in the differentiation of pancreatic beta cells. This gene may also play a protective role in acute pancreatitis, whereas increased expression of this gene may contribute to diabetic macular edema. Gene therapy using combinations of this gene and other pancreas-specific transcription factors may induce islet neogenesis and remediate hyperglycemia in type 1 diabetes. [provided by RefSeq, Apr 2011]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: Bcn; betacellulin; probetacellulin
Homo sapiens (human) : BTC (betacellulin)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Btc (betacellulin)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Btc (betacellulin)
Pan paniscus (bonobo/pygmy chimpanzee) : BTC (betacellulin)
Canis lupus familiaris (dog) : BTC (betacellulin)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Btc (betacellulin)
Sus scrofa (pig) : BTC (betacellulin)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38591,357,261 - 91,402,994 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv37591,786,287 - 91,831,939 (-)NCBIGRCm37mm9NCBIm37
MGSCv36592,432,461 - 92,478,113 (-)NCBImm8
Celera589,495,391 - 89,540,785 (-)NCBICelera
Cytogenetic Map5 E2NCBI
cM Map544.78NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated
RGD Disease Portals


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status


Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Btc
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 733574
Created: 2004-01-12
Species: Mus musculus
Last Modified: 2019-09-12
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.