CRIPTO (cripto, EGF-CFC family member) - Rat Genome Database

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Gene: CRIPTO (cripto, EGF-CFC family member) Sus scrofa
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Symbol: CRIPTO (Ensembl: TDGF1)
Name: cripto, EGF-CFC family member (Ensembl:teratocarcinoma-derived growth factor 1)
RGD ID: 14216004
Description: ENCODES a protein that exhibits coreceptor activity (ortholog); signaling receptor binding (ortholog); type I activin receptor binding (ortholog); INVOLVED IN anterior/posterior axis specification (ortholog); anterior/posterior axis specification, embryo (ortholog); cardiac muscle cell differentiation (ortholog); PARTICIPATES IN glypican signaling pathway; ASSOCIATED WITH colon cancer (ortholog); congenital heart disease (ortholog); Forebrain Defects (ortholog); FOUND IN apical plasma membrane (ortholog); cytoplasm (ortholog); extracellular space (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: TDGF1; teratocarcinoma-derived growth factor 1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1329,540,314 - 29,543,893 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11329,537,874 - 29,544,686 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21332,774,947 - 32,777,177 (+)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
anterior/posterior axis specification  (ISO)
anterior/posterior axis specification, embryo  (ISO)
anterior/posterior pattern specification  (IBA,IEA)
blood vessel development  (IBA,IEA)
cardiac muscle cell differentiation  (ISO)
cell migration involved in sprouting angiogenesis  (ISO)
cellular response to epidermal growth factor stimulus  (ISO)
cellular response to fibroblast growth factor stimulus  (ISO)
cellular response to hepatocyte growth factor stimulus  (ISO)
cellular response to interleukin-6  (ISO)
cellular response to tumor necrosis factor  (ISO)
cellular response to type II interferon  (ISO)
determination of left/right symmetry  (IBA,IEA)
epidermal growth factor receptor signaling pathway  (ISO)
fibroblast proliferation  (ISO)
gastrulation  (ISO)
heart development  (IBA,IEA)
in utero embryonic development  (ISO)
morphogenesis of a branching structure  (ISO)
negative regulation of apoptotic process  (ISO)
negative regulation of transforming growth factor beta receptor signaling pathway  (ISO)
nodal signaling pathway  (IBA,IEA)
positive regulation of cell migration  (ISO)
positive regulation of cell population proliferation  (ISO)
positive regulation of cell-matrix adhesion  (ISO)
positive regulation of endothelial cell migration  (ISO)
positive regulation of fibroblast proliferation  (ISO)
positive regulation of MAPK cascade  (ISO)
positive regulation of peptidyl-tyrosine phosphorylation  (ISO)
positive regulation of transcription by RNA polymerase II  (ISO)
regulation of fibroblast migration  (ISO)
regulation of signal transduction  (ISO)
signal transduction  (IEA)
vasculogenesis  (ISO)

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

Genomics

Comparative Map Data
CRIPTO
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1329,540,314 - 29,543,893 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11329,537,874 - 29,544,686 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21332,774,947 - 32,777,177 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CRIPTO
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38346,574,535 - 46,582,457 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl346,574,534 - 46,582,457 (+)EnsemblGRCh38hg38GRCh38
GRCh37346,616,025 - 46,623,947 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36346,594,217 - 46,598,957 (+)NCBINCBI36Build 36hg18NCBI36
Build 34346,594,216 - 46,598,954NCBI
Celera346,553,783 - 46,561,683 (+)NCBICelera
Cytogenetic Map3p21.31NCBI
HuRef346,658,557 - 46,666,459 (+)NCBIHuRef
CHM1_1346,566,173 - 46,574,073 (+)NCBICHM1_1
T2T-CHM13v2.0346,590,623 - 46,598,545 (+)NCBIT2T-CHM13v2.0
Cripto
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm399110,768,676 - 110,775,226 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl9110,768,671 - 110,775,226 (-)EnsemblGRCm39 Ensembl
GRCm389110,939,608 - 110,946,158 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl9110,939,603 - 110,946,158 (-)EnsemblGRCm38mm10GRCm38
MGSCv379110,842,112 - 110,848,662 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv369110,784,418 - 110,790,883 (-)NCBIMGSCv36mm8
Celera9110,664,719 - 110,671,594 (-)NCBICelera
Cytogenetic Map9F2NCBI
cM Map960.79NCBI
Cripto
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr88119,803,182 - 119,808,714 (-)NCBIGRCr8
mRatBN7.28110,924,774 - 110,938,545 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl8110,925,024 - 110,930,308 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.08119,215,266 - 119,220,909 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8119,215,495 - 119,219,232 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.08118,554,829 - 118,560,094 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.48115,341,587 - 115,346,871 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera8110,206,645 - 110,212,260 (-)NCBICelera
Cytogenetic Map8q32NCBI
Cripto
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542025,477,122 - 25,479,969 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542025,476,975 - 25,479,969 (-)NCBIChiLan1.0ChiLan1.0
CRIPTO
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2246,530,938 - 46,535,958 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1346,535,714 - 46,540,728 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0346,473,282 - 46,478,454 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1347,577,949 - 47,583,126 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl347,577,949 - 47,583,126 (+)Ensemblpanpan1.1panPan2
CRIPTO
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12042,137,939 - 42,140,590 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2042,053,910 - 42,056,560 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02042,620,327 - 42,622,979 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2042,620,327 - 42,623,866 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12041,861,683 - 41,864,330 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02042,262,807 - 42,265,458 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02042,543,717 - 42,546,368 (-)NCBIUU_Cfam_GSD_1.0
Cripto
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118200,900,937 - 200,905,070 (+)NCBIHiC_Itri_2
SpeTri2.0NW_004936596451,483 - 453,892 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CRIPTO
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1227,993,724 - 8,000,935 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl227,997,383 - 8,000,629 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666041159,149,573 - 159,153,094 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cripto
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462473074,547,226 - 74,550,526 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in CRIPTO
120 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system reproductive system respiratory system
High
Medium 1
Low 2 2 1 1 2 6 1 1
Below cutoff 4 2 2

Sequence


RefSeq Acc Id: ENSSSCT00000024900   ⟹   ENSSSCP00000027715
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1329,540,151 - 29,544,188 (+)Ensembl
RefSeq Acc Id: XM_013981587   ⟹   XP_013837041
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11329,537,874 - 29,544,686 (+)NCBI
Sequence:
RefSeq Acc Id: XP_013837041   ⟸   XM_013981587
- UniProtKB: A0A4X1T8Z7 (UniProtKB/TrEMBL),   A0A8D0M4E8 (UniProtKB/TrEMBL),   I3LUB6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSSCP00000027715   ⟸   ENSSSCT00000024900
Protein Domains
EGF-like


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000023395 Ensembl, UniProtKB/TrEMBL
  ENSSSCG00005044531 UniProtKB/TrEMBL
  ENSSSCG00015019353 UniProtKB/TrEMBL
  ENSSSCG00025054994 UniProtKB/TrEMBL
  ENSSSCG00030033497 UniProtKB/TrEMBL
  ENSSSCG00035038324 UniProtKB/TrEMBL
  ENSSSCG00040027076 UniProtKB/TrEMBL
  ENSSSCG00045014435 UniProtKB/TrEMBL
  ENSSSCG00050056914 UniProtKB/TrEMBL
  ENSSSCG00055008832 UniProtKB/TrEMBL
  ENSSSCG00060007623 UniProtKB/TrEMBL
  ENSSSCG00065034794 UniProtKB/TrEMBL
  ENSSSCG00070007386 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000024900.4 UniProtKB/TrEMBL
  ENSSSCT00005071682.1 UniProtKB/TrEMBL
  ENSSSCT00015025553.1 UniProtKB/TrEMBL
  ENSSSCT00025075236.1 UniProtKB/TrEMBL
  ENSSSCT00030046365.1 UniProtKB/TrEMBL
  ENSSSCT00035050854.1 UniProtKB/TrEMBL
  ENSSSCT00040036260.1 UniProtKB/TrEMBL
  ENSSSCT00045024623.1 UniProtKB/TrEMBL
  ENSSSCT00050077593.1 UniProtKB/TrEMBL
  ENSSSCT00055017254.1 UniProtKB/TrEMBL
  ENSSSCT00060009705.1 UniProtKB/TrEMBL
  ENSSSCT00065047349.1 UniProtKB/TrEMBL
  ENSSSCT00070014213.1 UniProtKB/TrEMBL
Gene3D-CATH Laminin UniProtKB/TrEMBL
InterPro Cripto_growth_factor UniProtKB/TrEMBL
  Cryptic/Cripto_CFC-dom UniProtKB/TrEMBL
  EGF-like_dom UniProtKB/TrEMBL
NCBI Gene TDGF1 ENTREZGENE
Pfam CFC UniProtKB/TrEMBL
PIRSF Cripto_growth_factor UniProtKB/TrEMBL
PROSITE EGF_1 UniProtKB/TrEMBL
  EGF_3 UniProtKB/TrEMBL
Superfamily-SCOP EGF/Laminin UniProtKB/TrEMBL
UniProt A0A4X1T8Z7 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D0M4E8 ENTREZGENE, UniProtKB/TrEMBL
  I3LUB6 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2023-06-13 CRIPTO  cripto, EGF-CFC family member  TDGF1  teratocarcinoma-derived growth factor 1  Symbol and/or name change 5135510 APPROVED