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Gene: RHBDF1 (rhomboid 5 homolog 1) Homo sapiens
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Symbol: RHBDF1
Name: rhomboid 5 homolog 1
Description: Predicted to have growth factor binding activity and serine-type endopeptidase activity. Involved in several processes, including negative regulation of protein secretion; regulation of epidermal growth factor receptor signaling pathway; and regulation of proteasomal protein catabolic process. Localizes to the Golgi membrane and endoplasmic reticulum membrane; INTERACTS WITH 17beta-estradiol; 2-methylcholine; 3-isobutyl-1-methyl-7H-xanthine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: C16orf8; Dist1; EGFR-RS; epidermal growth factor receptor, related sequence; epidermal growth factor receptor-related protein; FLJ2235; FLJ22357; gene-89; gene-90; hDist1; inactive rhomboid protein 1; iRhom1; p100hRho; rhomboid 5 homolog 1 (Drosophila); rhomboid family 1; rhomboid family 1 (drosophila); rhomboid family member 1
Orthologs:
Mus musculus (house mouse) : Rhbdf1 (rhomboid 5 homolog 1)  MGI  Alliance
Rattus norvegicus (Norway rat) : Rhbdf1 (rhomboid 5 homolog 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Rhbdf1 (rhomboid 5 homolog 1)
Pan paniscus (bonobo/pygmy chimpanzee) : RHBDF1 (rhomboid 5 homolog 1)
Canis lupus familiaris (dog) : RHBDF1 (rhomboid 5 homolog 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Rhbdf1 (rhomboid 5 homolog 1)
Sus scrofa (pig) : RHBDF1 (rhomboid 5 homolog 1)
Chlorocebus sabaeus (green monkey) : RHBDF1 (rhomboid 5 homolog 1)
Heterocephalus glaber (naked mole-rat) : Rhbdf1 (rhomboid 5 homolog 1)
more info ...
Related Pseudogenes: RHBDF1P1  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38 Ensembl1658,059 - 76,355 (-)Ensembl
GRCh381658,059 - 76,355 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh3716108,058 - 126,354 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361648,058 - 62,591 (-)NCBINCBI36hg18NCBI36
Build 341648,058 - 62,591NCBI
Celera16309,954 - 324,535 (-)NCBI
Cytogenetic Map16p13.3NCBI
HuRef1626,451 - 41,032 (-)NCBIHuRef
CHM1_116107,996 - 122,575 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on RHBDF1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1312890
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2019-12-25
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.