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Gene: SLIT3 (slit guidance ligand 3) Homo sapiens
Symbol: SLIT3
Name: slit guidance ligand 3
RGD ID: 733245
Description: Exhibits Roundabout binding activity. Involved in several processes, including apoptotic process involved in luteolysis; axon extension involved in axon guidance; and response to cortisol. Localizes to extracellular space.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: FLJ10764; MEGF5; multiple EGF-like domains protein 5; multiple epidermal growth factor-like domains protein 5; SLIL2; slit homolog 3; Slit-3; SLIT1; slit2
Mus musculus (house mouse) : Slit3 (slit guidance ligand 3)  MGI  Alliance
Rattus norvegicus (Norway rat) : Slit3 (slit guidance ligand 3)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Slit3 (slit guidance ligand 3)
Pan paniscus (bonobo/pygmy chimpanzee) : SLIT3 (slit guidance ligand 3)
Canis lupus familiaris (dog) : SLIT3 (slit guidance ligand 3)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Slit3 (slit guidance ligand 3)
Sus scrofa (pig) : SLIT3 (slit guidance ligand 3)
Chlorocebus sabaeus (African green monkey) : SLIT3 (slit guidance ligand 3)
Heterocephalus glaber (naked mole-rat) : Slit3 (slit guidance ligand 3)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 Ensembl5168,661,733 - 169,301,129 (-)EnsemblGRCh38hg38GRCh38
GRCh38.p13 Ensembl5168,661,733 - 169,301,139 (-)EnsemblGRCh38hg38GRCh38
GRCh385168,661,740 - 169,301,139 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh375168,088,738 - 168,728,133 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 365168,025,857 - 168,660,554 (-)NCBINCBI36hg18NCBI36
Build 345168,025,856 - 168,660,554NCBI
Celera5164,128,856 - 164,759,439 (-)NCBI
Cytogenetic Map5q34-q35.1NCBI
HuRef5163,187,021 - 163,825,867 (-)NCBIHuRef
CHM1_15167,521,662 - 168,160,538 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on SLIT3
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 733245
Created: 2004-01-12
Species: Homo sapiens
Last Modified: 2020-09-08
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.