Egfl6 (EGF like domain multiple 6)

Gene: Egfl6 (EGF like domain multiple 6) Chinchilla lanigera

Analyze

Symbol:

Egfl6

Name:

EGF like domain multiple 6

RGD ID:

8802559

Description:

INVOLVED IN extracellular matrix organization (ortholog); positive regulation of cell-substrate adhesion (ortholog); ASSOCIATED WITH autistic disorder (ortholog); bladder exstrophy-epispadias-cloacal exstrophy complex (ortholog); genetic disease (ortholog); FOUND IN basement membrane (ortholog); extracellular matrix (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

EGF-like-domain, multiple 6; epidermal growth factor-like protein 6

RGD Orthologs

Alliance Genes

More Info

more info ...

Latest Assembly:

ChiLan1.0 - Chinchilla ChiLan1.0 Assembly

Position:

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955519	4,556,610 - 4,616,296 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955519	4,557,007 - 4,616,095 (-)	NCBI	ChiLan1.0	ChiLan1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

autistic disorder (ISO)

bladder exstrophy-epispadias-cloacal exstrophy complex (ISO)

genetic disease (ISO)

Joubert syndrome 1 (ISO)

Neurodevelopmental Disorders (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

extracellular matrix organization (ISO)

positive regulation of cell-substrate adhesion (ISO)

Cellular Component

basement membrane (ISO)

extracellular matrix (ISO)

Molecular Function

protein binding (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Transitive Annotation Pipeline	Automated assignment of GO, PW and RDO ISO annotations across species

Additional References at PubMed

PMID:22301074

Genomics

Comparative Map Data

Egfl6
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955519	4,556,610 - 4,616,296 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955519	4,557,007 - 4,616,095 (-)	NCBI	ChiLan1.0	ChiLan1.0

EGFL6
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	X	13,569,601 - 13,633,575 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	X	13,569,601 - 13,633,575 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	X	13,587,720 - 13,651,694 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	X	13,497,662 - 13,561,615 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	X	13,347,397 - 13,411,350	NCBI
Celera	X	17,704,800 - 17,768,780 (+)	NCBI		Celera
Cytogenetic Map	X	p22.2	NCBI
HuRef	X	11,346,706 - 11,404,147 (+)	NCBI		HuRef
CHM1_1	X	13,618,522 - 13,682,553 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	X	13,151,011 - 13,214,962 (+)	NCBI		T2T-CHM13v2.0

Egfl6
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	X	165,306,003 - 165,368,712 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	X	165,306,003 - 165,368,716 (-)	Ensembl		GRCm39 Ensembl
GRCm38	X	166,523,007 - 166,585,716 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	X	166,523,007 - 166,585,720 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	X	162,960,939 - 163,023,648 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	X	161,867,112 - 161,929,821 (-)	NCBI		MGSCv36	mm8
Celera	X	149,703,700 - 149,765,223 (-)	NCBI		Celera
Cytogenetic Map	X	F5	NCBI
cM Map	X	77.66	NCBI

Egfl6
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	X	31,515,752 - 31,573,699 (+)	NCBI		GRCr8
mRatBN7.2	X	27,884,087 - 27,942,044 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	X	27,884,125 - 27,942,044 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	X	28,918,085 - 28,976,353 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	X	32,353,819 - 32,411,722 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	X	28,532,727 - 28,590,990 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	X	29,430,789 - 29,488,737 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	X	29,430,831 - 29,488,739 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	X	29,823,750 - 29,881,382 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	X	48,568,644 - 48,626,802 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	X	28,256,591 - 28,314,648 (+)	NCBI		Celera
Cytogenetic Map	X	q13	NCBI

EGFL6
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	X	15,348,589 - 15,413,279 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	X	15,352,255 - 15,416,854 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	X	6,177,141 - 6,240,969 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	X	13,465,614 - 13,529,394 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	X	13,465,605 - 13,529,474 (+)	Ensembl	panpan1.1		panPan2

EGFL6
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	X	9,944,648 - 10,062,699 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	X	9,995,846 - 10,062,266 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	X	9,816,026 - 10,037,235 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	X	9,811,918 - 10,020,620 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	X	9,955,601 - 10,020,150 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	X	9,802,862 - 10,089,431 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	X	9,836,276 - 10,080,587 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	X	10,020,615 - 10,106,745 (+)	NCBI		UU_Cfam_GSD_1.0

Egfl6
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	X	3,156,546 - 3,214,971 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936470	3,156,518 - 3,215,990 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936470	3,156,593 - 3,215,039 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

EGFL6
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	X	10,217,924 - 10,283,810 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	X	10,218,108 - 10,284,152 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	X	11,171,935 - 11,237,889 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

EGFL6
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	X	12,051,172 - 12,116,860 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	X	12,052,518 - 12,116,845 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666056	13,881,736 - 13,946,078 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Egfl6
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624882	513,227 - 575,126 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624882	513,105 - 575,126 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_005409208	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AGCD01067986	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AGCD01067987	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AGCD01067988	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	GBDJ01301779	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSCLAT00000000864 ⟹ ENSCLAP00000000827

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0 Ensembl	NW_004955519	4,556,610 - 4,616,296 (-)	Ensembl

RefSeq Acc Id:

XM_005409208 ⟹ XP_005409265

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0	NW_004955519	4,557,007 - 4,616,095 (-)	NCBI

Sequence:

show sequence

TCGTGCTGGATGGAGGCGGGTCCCAACCAGATGTGCACGGCCTAGGGGCCCCGCCCTCTCGCTC
TTGCTCCAGGCTGCTTCCCCGCGGAGGAGCGAACGCACCTCGCCAGGCACCCCAGCCTCTCACA
GCCGCTGGAGCTAGGACTGCACCGCAAGTTGCAGACAAGCCGAGTCCCCGAGCGGCAGAGGAGA
GAGGAGGCGGCGCTCACGGAGACCCACATCCAGACAACCGCCTTGCCAGGGGGCGCAGAAGGAG
GAGGGCGACGCTTGGCGCGAACATGCCGCCGTCCTGGGGCCTCGCACTCCAGCTGCTGCTCCCC
TGGGTGGCAGGTGGATTAGGGAACGCGGCCAGTCCGAGGGATCACGGGTTGTTGGCGTTGGCAC
GCCAGCCTGGGCTCTGTCTCTATGGAGCGAAATTGGCCTGCTGCTACGGCTGGAGAAGGAACAT
CAAGGGAGTCTGTGAAGCCACCTGCGATCCTGGGTGCAAGTTCGGCGAGTGTGTGGGCCCGAAC
AAGTGTAGATGCTTTCCAGGATATACCGGGAAAAGCTGCAGCCAAGATGTGAACGAGTGTGGAA
TCAAACCCCGGCTGTGCCAGCACAGATGTGTGAACACACACGGCAGCTACAAATGCTTCTGTCT
CAGTGGCCACACACTCATGCCAGACGCGACTTGTGCCAACTCTCGGACCTGTGCCAGGACCAAC
TGCCAGTATGGCTGTGAAGATACAGAGGAAGGACCTCGATGTCTGTGTCCATCCTCAGGACTCC
GTCTGGCCTCAAATGGAAGGATGTGCCTAGATATTGATGAATGTGCCTCTGGAAAAGCGGTCTG
CCCCTTTAATCGGAGATGTGTGAACACATTTGGAAGCTACTACTGCAAATGTCACATTGGCTTT
GAACTGAAGTATAGCGGTGGTCGATATGACTGCGTGGATATAAACGAATGTGCTGTGAGTATCC
ATGCGTGCACCCCACATGCCAACTGCCTCAATACCCAAGGATCCTTCAAGTGCAAATGCAAGCA
GGGATACAAAGGCAGTGGATTTCAGTGTTCTGTTATCCCTGAAAATTCTGTGAGAGAAGTCCTC
AGAGCACCTGGGATCATCAAAGACAAGATCAAGAAGTTGCTTGCTCACAAAAACAGCATGAAAA
AGAAGATAAAAGTGAAAAATGTCACCCCAGGACCCACTGGGACACGTGCCCCTAAGGCTACCTC
AAAGCCCTTCAGCTCTAAAGAGAATCTTCACAGGGATGGGAACTCTCCTAGAGACAAAAATTGG
AATAAAGAAAAAATCAAAGGGCTTGAGGAAGAGAAAAGAGAAGAGAAAGCCCTGAAGAATGACG
TGGAACAGGAGCGAAGCCTCCGAGGAGATGTGTTTTCCCCCAAGGTGAATGAAGCAGGTAATTT
GAGTTTGGATCTGGCCCAAAGAAAAGTGCTGAATTCCAAGCTGGAATACAAAGGTTTAAATATC
TCAGCTGACTGCAGCTTTGATCATGGGGTCTGTGACTGGAAACAAGACAGAGAAGATGATTTTG
ACTGGAATCCTGCTGATCGAGATAATGCTGTTGGCTATTATATGGCAGTTCCGGCCTTGGCAGG
GCACAGGAAGGATATTGGTCGATTGAAACTTCTCCTCCCAAACCTGCAGCCCCAAAGCAACTTC
TGCTTGCTCTTTGATTACCGGCTGGCGGGAGAGAAAGTAGGGAAACTTCGTGTGTTTGTGAAAA
ACAGTAACAACGTGCTGGCATGGGAAGAGACCAAGAGTGAGGATGAAAGGTGGAAGACGGGAAA
AATTCAGTTGTATCAAGGGATTGATGCAACCAAAAGTATCATTTTTGAAGCAGAACGTGGCAAA
GGCAAAACTGGAGAAATTGCAGTGGACAGCGTCTTGCTCCTTTCAGACTCCTGTCCCAGTGGCC
TTTTAACTGTGGCAGGTTGAACGTTACTGTTGTCTTTTGTATCACAACATTTGACTTTTTTTTT
CTCAGTTCTCTATTTTTTGATGTTATGTCATAAGAGTCCCCATTTTAGAAATACAACTTGAACA
TTGTAATATACCAATAGGAGCATTGTAAAATGCCTCTCTTGTACCAGATGTGCCAATATTTGCT
TTAAATAAAGTGCCACTGTGTCTTCTCTA

hide sequence

Protein Sequences


Protein RefSeqs	XP_005409265	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCLAP00000000827
	ENSCLAP00000000827.1

RefSeq Acc Id:

XP_005409265 ⟸ XM_005409208

- UniProtKB:

A0A8C2UIY4 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MPPSWGLALQLLLPWVAGGLGNAASPRDHGLLALARQPGLCLYGAKLACCYGWRRNIKGVCEAT
CDPGCKFGECVGPNKCRCFPGYTGKSCSQDVNECGIKPRLCQHRCVNTHGSYKCFCLSGHTLMP
DATCANSRTCARTNCQYGCEDTEEGPRCLCPSSGLRLASNGRMCLDIDECASGKAVCPFNRRCV
NTFGSYYCKCHIGFELKYSGGRYDCVDINECAVSIHACTPHANCLNTQGSFKCKCKQGYKGSGF
QCSVIPENSVREVLRAPGIIKDKIKKLLAHKNSMKKKIKVKNVTPGPTGTRAPKATSKPFSSKE
NLHRDGNSPRDKNWNKEKIKGLEEEKREEKALKNDVEQERSLRGDVFSPKVNEAGNLSLDLAQR
KVLNSKLEYKGLNISADCSFDHGVCDWKQDREDDFDWNPADRDNAVGYYMAVPALAGHRKDIGR
LKLLLPNLQPQSNFCLLFDYRLAGEKVGKLRVFVKNSNNVLAWEETKSEDERWKTGKIQLYQGI
DATKSIIFEAERGKGKTGEIAVDSVLLLSDSCPSGLLTVAG

hide sequence

RefSeq Acc Id:

ENSCLAP00000000827 ⟸ ENSCLAT00000000864

Protein Domains

EGF-like MAM

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCLAG00000000643	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCLAT00000000864	ENTREZGENE
	ENSCLAT00000000864.1	UniProtKB/TrEMBL
Gene3D-CATH	2.60.120.200	UniProtKB/TrEMBL
	Laminin	UniProtKB/TrEMBL
InterPro	ConA-like_dom_sf	UniProtKB/TrEMBL
	EGF-like_Ca-bd_dom	UniProtKB/TrEMBL
	EGF-like_dom	UniProtKB/TrEMBL
	EGF-type_Asp/Asn_hydroxyl_site	UniProtKB/TrEMBL
	EGF_Ca-bd_CS	UniProtKB/TrEMBL
	Growth_fac_rcpt_cys_sf	UniProtKB/TrEMBL
	MAM_dom	UniProtKB/TrEMBL
NCBI Gene	Egfl6	ENTREZGENE
PANTHER	PA14 DOMAIN-CONTAINING PROTEIN	UniProtKB/TrEMBL
	PTHR24050:SF24	UniProtKB/TrEMBL
Pfam	EGF_CA	UniProtKB/TrEMBL
	MAM	UniProtKB/TrEMBL
PROSITE	ASX_HYDROXYL	UniProtKB/TrEMBL
	EGF_3	UniProtKB/TrEMBL
	EGF_CA	UniProtKB/TrEMBL
	MAM_2	UniProtKB/TrEMBL
SMART	EGF	UniProtKB/TrEMBL
	EGF_CA	UniProtKB/TrEMBL
	MAM	UniProtKB/TrEMBL
Superfamily-SCOP	SSF49899	UniProtKB/TrEMBL
	SSF57184	UniProtKB/TrEMBL
UniProt	A0A8C2UIY4	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2016-08-03	Egfl6	EGF like domain multiple 6		EGF-like-domain, multiple 6	Symbol and/or name change	5135510	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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