HEG1 (heart development protein with EGF like domains 1) - Rat Genome Database

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Gene: HEG1 (heart development protein with EGF like domains 1) Pan paniscus
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Symbol: HEG1
Name: heart development protein with EGF like domains 1
RGD ID: 11966453
Description: ENCODES a protein that exhibits calcium ion binding (inferred); INVOLVED IN cardiac atrium morphogenesis (ortholog); cardiac muscle tissue growth (ortholog); cell-cell junction organization (ortholog); ASSOCIATED WITH alkaptonuria (ortholog); familial hypocalciuric hypercalcemia (ortholog); Familial Thoracic Aortic Aneurysm 7 (ortholog); FOUND IN cell surface (inferred); cell-cell junction (inferred); external side of plasma membrane (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: HEG homolog 1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22122,961,542 - 123,051,716 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan13122,966,322 - 123,056,297 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v03122,091,832 - 122,204,436 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.13128,964,878 - 129,028,313 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3128,969,817 - 129,028,317 (-)Ensemblpanpan1.1panPan2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
HEG1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22122,961,542 - 123,051,716 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan13122,966,322 - 123,056,297 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v03122,091,832 - 122,204,436 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.13128,964,878 - 129,028,313 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3128,969,817 - 129,028,317 (-)Ensemblpanpan1.1panPan2
HEG1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh383124,965,710 - 125,055,997 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl3124,965,710 - 125,055,997 (-)EnsemblGRCh38hg38GRCh38
GRCh373124,684,554 - 124,774,841 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 363126,167,244 - 126,257,492 (-)NCBINCBI36Build 36hg18NCBI36
Celera3123,091,267 - 123,182,155 (-)NCBICelera
Cytogenetic Map3q21.2NCBI
HuRef3122,058,734 - 122,148,741 (-)NCBIHuRef
CHM1_13124,647,692 - 124,738,018 (-)NCBICHM1_1
T2T-CHM13v2.03127,691,280 - 127,781,663 (-)NCBIT2T-CHM13v2.0
Heg1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391633,504,754 - 33,591,946 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1633,504,740 - 33,591,946 (+)EnsemblGRCm39 Ensembl
GRCm381633,684,384 - 33,771,576 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1633,684,370 - 33,771,576 (+)EnsemblGRCm38mm10GRCm38
MGSCv371633,684,552 - 33,768,281 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361633,645,203 - 33,687,942 (+)NCBIMGSCv36mm8
Celera1634,168,044 - 34,252,062 (+)NCBICelera
Cytogenetic Map16B3NCBI
cM Map1624.17NCBI
Heg1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81180,512,096 - 80,600,150 (-)NCBIGRCr8
mRatBN7.21167,006,954 - 67,095,020 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1166,957,190 - 67,095,051 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.01170,234,248 - 70,322,966 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1170,236,888 - 70,322,690 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01173,322,608 - 73,410,501 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41168,828,748 - 68,912,073 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.41168,828,748 - 68,889,177 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1166,457,252 - 66,545,180 (-)NCBICelera
Cytogenetic Map11q22NCBI
Heg1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495542724,035,193 - 24,115,483 (-)NCBIChiLan1.0ChiLan1.0
HEG1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13327,982,127 - 28,044,379 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3327,987,252 - 28,044,363 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3328,005,028 - 28,093,824 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03328,214,315 - 28,303,777 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3328,216,310 - 28,278,479 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13328,013,569 - 28,102,848 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03328,058,048 - 28,147,010 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03328,677,414 - 28,766,962 (-)NCBIUU_Cfam_GSD_1.0
Heg1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405602126,352,183 - 126,427,942 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936725261,712 - 336,414 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936725261,809 - 336,390 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HEG1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13135,298,377 - 135,358,670 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.113135,268,566 - 135,358,673 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213144,767,453 - 144,829,493 (-)NCBISscrofa10.2Sscrofa10.2susScr3
HEG1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12255,782,039 - 55,874,679 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2255,809,901 - 55,871,402 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666041110,440,982 - 110,530,309 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Heg1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247311,020,805 - 1,092,995 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247311,015,889 - 1,092,875 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSPPAT00000059551   ⟹   ENSPPAP00000036658
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl3128,969,817 - 129,028,317 (-)Ensembl
RefSeq Acc Id: XM_034957245   ⟹   XP_034813136
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v22122,961,542 - 123,051,715 (-)NCBI
NHGRI_mPanPan13122,966,322 - 123,056,113 (-)NCBI
Mhudiblu_PPA_v03122,091,832 - 122,187,883 (-)NCBI
RefSeq Acc Id: XM_034957246   ⟹   XP_034813137
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v22122,961,542 - 123,051,715 (-)NCBI
NHGRI_mPanPan13122,966,322 - 123,056,113 (-)NCBI
Mhudiblu_PPA_v03122,091,832 - 122,187,883 (-)NCBI
RefSeq Acc Id: XM_034957247   ⟹   XP_034813138
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v22122,961,542 - 123,051,716 (-)NCBI
NHGRI_mPanPan13122,966,322 - 123,056,297 (-)NCBI
Mhudiblu_PPA_v03122,091,832 - 122,187,883 (-)NCBI
Protein Sequences
Protein RefSeqs XP_034813136 (Get FASTA)   NCBI Sequence Viewer  
  XP_034813137 (Get FASTA)   NCBI Sequence Viewer  
  XP_034813138 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSPPAP00000036658.1
RefSeq Acc Id: XP_034813137   ⟸   XM_034957246
- Peptide Label: isoform X2
- UniProtKB: A0A2R9C6Y0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_034813138   ⟸   XM_034957247
- Peptide Label: isoform X3
- UniProtKB: A0A2R9C6Y0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_034813136   ⟸   XM_034957245
- Peptide Label: isoform X1
- UniProtKB: A0A2R9C6Y0 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSPPAP00000036658   ⟸   ENSPPAT00000059551
Protein Domains
EGF-like


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000041079 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000059551.1 UniProtKB/TrEMBL
Gene3D-CATH Laminin UniProtKB/TrEMBL
InterPro EGF-like_Ca-bd_dom UniProtKB/TrEMBL
  EGF-like_dom UniProtKB/TrEMBL
  EGF-type_Asp/Asn_hydroxyl_site UniProtKB/TrEMBL
  EGF_Ca-bd_CS UniProtKB/TrEMBL
  NOTCH1_EGF-like UniProtKB/TrEMBL
NCBI Gene HEG1 ENTREZGENE
PANTHER PROTEIN HEG HOMOLOG 1 UniProtKB/TrEMBL
  PTHR24037 UniProtKB/TrEMBL
Pfam EGF UniProtKB/TrEMBL
  EGF_CA UniProtKB/TrEMBL
PROSITE ASX_HYDROXYL UniProtKB/TrEMBL
  EGF_1 UniProtKB/TrEMBL
  EGF_2 UniProtKB/TrEMBL
  EGF_3 UniProtKB/TrEMBL
  EGF_CA UniProtKB/TrEMBL
SMART EGF UniProtKB/TrEMBL
  EGF_CA UniProtKB/TrEMBL
Superfamily-SCOP EGF/Laminin UniProtKB/TrEMBL
UniProt A0A2R9C6Y0 ENTREZGENE, UniProtKB/TrEMBL