Gene: APPL2 (adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2) Homo sapiens
Analyze
Symbol:
APPL2
Name:
adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2
Description:
Exhibits phosphatidylinositol binding activity; phosphatidylserine binding activity; and protein homodimerization activity. Involved in several processes, including negative regulation of glucose import; protein homotetramerization; and protein import into nucleus. Localizes to the endosome membrane; nucleus; and plasma membrane.
Type:
protein-coding
RefSeq Status:
REVIEWED
Also known as:
adapter protein containing PH domain, PTB domain and leucine zipper motif 2; adaptor protein containing PH domain, PTB domain and leucine zipper motif 2; adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2; DCC-interacting protein 13-beta; DIP13 beta; dip13-beta; DIP13B; FLJ10659
Orthologs:
Species
Gene symbol and name
Data Source
Assertion derived from
less info ...
Orthologs 1
Mus musculus (house mouse):
Appl2 (adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2) HGNC
EggNOG, Ensembl, HGNC, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Rattus norvegicus (Norway rat):
Appl2 (adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2) HGNC
EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Chinchilla lanigera (long-tailed chinchilla):
Appl2 (adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2) NCBI
Ortholog
Pan paniscus (bonobo/pygmy chimpanzee):
APPL2 (adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2) NCBI
Ortholog
Canis lupus familiaris (dog):
APPL2 (adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2) HGNC
EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, Treefam
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):
Appl2 (adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2) NCBI
Ortholog
Sus scrofa (pig):
APPL2 (adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2) HGNC
EggNOG, Ensembl, Inparanoid, NCBI, OMA, OrthoDB, Panther, Treefam
Other homologs 2
Rattus norvegicus (Norway rat):
Appl1 (adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1) HGNC
OrthoMCL
Mus musculus (house mouse):
Appl1 (adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1) HGNC
OrthoMCL
Canis lupus familiaris (dog):
APPL1 (adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1) HGNC
OrthoMCL
Alliance orthologs 3
Mus musculus (house mouse):
Appl2 (adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2)
Alliance
DIOPT (Ensembl Compara, HGNC, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, TreeFam)
Rattus norvegicus (Norway rat):
Appl2 (adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2)
Alliance
DIOPT (Ensembl Compara, HGNC, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, TreeFam)
Danio rerio (zebrafish):
appl2 (adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2)
Alliance
DIOPT (Ensembl Compara, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, Roundup, TreeFam, ZFIN)
Allele / Splice:
See ClinVar data
Latest Assembly:
GRCh38 - Human Genome Assembly GRCh38
Position:
Human Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl GRCh38 12 105,173,297 - 105,236,230 (-) NCBI GRCh38 GRCh38 hg38 GRCh38 GRCh37 12 105,567,075 - 105,630,008 (-) NCBI GRCh37 GRCh37 hg19 GRCh37 Build 36 12 104,091,205 - 104,154,138 (-) NCBI NCBI36 hg18 NCBI36 Celera 12 105,231,366 - 105,294,273 (-) NCBI Cytogenetic Map 12 q23.3 NCBI HuRef 12 102,626,453 - 102,689,404 (-) NCBI HuRef CHM1_1 12 105,532,775 - 105,595,738 (-) NCBI CHM1_1
JBrowse:
View Region in Genome Browser (JBrowse)
Model
Gene-Chemical Interaction Annotations
(+)-schisandrin B multiple interactions ISO RGD:1563028 6480464 schizandrin B inhibits the reaction [Carbon Tetrachloride results in increased expression of APPL2 mRNA] CTD PMID:31150632 (-)-epigallocatechin 3-gallate multiple interactions EXP 6480464 [potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of APPL2 mRNA CTD PMID:22079256 1,3,5-trinitro-1,3,5-triazinane decreases expression ISO RGD:1563028 6480464 cyclonite results in decreased expression of APPL2 mRNA CTD PMID:25559034 17alpha-ethynylestradiol increases expression ISO RGD:1558154 6480464 Ethinyl Estradiol results in increased expression of APPL2 mRNA CTD PMID:17942748 2,3,7,8-tetrachlorodibenzodioxine multiple interactions ISO RGD:1558154 6480464 Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to APPL2 promoter] CTD PMID:19654925 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO RGD:1558154 6480464 Tetrachlorodibenzodioxin affects the expression of APPL2 mRNA CTD PMID:21570461 2-hydroxypropanoic acid decreases expression EXP 6480464 Lactic Acid results in decreased expression of APPL2 mRNA CTD PMID:30851411 Aroclor 1254 decreases expression ISO RGD:1558154 6480464 Chlorodiphenyl (54% Chlorine) results in decreased expression of APPL2 mRNA CTD PMID:23650126 benzo[a]pyrene decreases expression ISO RGD:1558154 6480464 Benzo(a)pyrene results in decreased expression of APPL2 mRNA CTD PMID:19770486 benzo[a]pyrene decreases expression EXP 6480464 Benzo(a)pyrene results in decreased expression of APPL2 mRNA CTD PMID:22316170 bisphenol A affects expression ISO RGD:1563028 6480464 bisphenol A affects the expression of APPL2 mRNA CTD PMID:25181051 carbon nanotube decreases expression ISO RGD:1558154 6480464 Nanotubes, Carbon analog results in decreased expression of APPL2 mRNA, Nanotubes, Carbon results in decreased expression of APPL2 mRNA CTD PMID:25554681 choline multiple interactions ISO RGD:1558154 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of APPL2 gene CTD PMID:20938992 chromium(6+) affects expression ISO RGD:1558154 6480464 chromium hexavalent ion affects the expression of APPL2 mRNA CTD PMID:28472532 cisplatin increases expression EXP 6480464 Cisplatin results in increased expression of APPL2 mRNA CTD PMID:27392435 cobalt dichloride decreases expression EXP 6480464 cobaltous chloride results in decreased expression of APPL2 mRNA CTD PMID:19320972 cyclosporin A decreases expression EXP 6480464 Cyclosporine results in decreased expression of APPL2 mRNA CTD PMID:20106945 dioxygen increases expression ISO RGD:1558154 6480464 Oxygen deficiency results in increased expression of APPL2 mRNA CTD PMID:20880076 dioxygen multiple interactions ISO RGD:1558154 6480464 [NFE2L2 protein affects the susceptibility to Oxygen] which affects the expression of APPL2 mRNA CTD PMID:30529165 dorsomorphin multiple interactions EXP 6480464 [NOG protein co-treated with trichostatin A co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of APPL2 mRNA CTD PMID:27188386 doxorubicin decreases expression EXP 6480464 Doxorubicin results in decreased expression of APPL2 mRNA CTD PMID:29803840 endosulfan decreases expression ISO RGD:1563028 6480464 Endosulfan results in decreased expression of APPL2 mRNA CTD PMID:29391264 ethanol increases expression ISO RGD:1558154 6480464 Ethanol results in increased expression of APPL2 mRNA CTD PMID:30319688 flutamide increases expression ISO RGD:1563028 6480464 Flutamide results in increased expression of APPL2 mRNA CTD PMID:24793618 folic acid multiple interactions ISO RGD:1558154 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of APPL2 gene CTD PMID:20938992 geldanamycin increases expression EXP 6480464 geldanamycin results in increased expression of APPL2 mRNA CTD PMID:26705709 isoprenaline increases expression ISO RGD:1558154 6480464 Isoproterenol results in increased expression of APPL2 mRNA CTD PMID:20003209 L-methionine multiple interactions ISO RGD:1558154 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of APPL2 gene CTD PMID:20938992 methamphetamine increases expression ISO RGD:1558154 6480464 Methamphetamine results in increased expression of APPL2 mRNA CTD PMID:26307267 methyl methanesulfonate increases expression EXP 6480464 Methyl Methanesulfonate results in increased expression of APPL2 mRNA CTD PMID:23649840 paracetamol affects expression ISO RGD:1558154 6480464 Acetaminophen affects the expression of APPL2 mRNA CTD PMID:17562736 potassium chromate decreases expression EXP 6480464 potassium chromate(VI) results in decreased expression of APPL2 mRNA CTD PMID:22079256 potassium chromate multiple interactions EXP 6480464 [potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of APPL2 mRNA CTD PMID:22079256 quercetin decreases expression EXP 6480464 Quercetin results in decreased expression of APPL2 mRNA CTD PMID:21632981 rac-lactic acid decreases expression EXP 6480464 Lactic Acid results in decreased expression of APPL2 mRNA CTD PMID:30851411 SB 431542 multiple interactions EXP 6480464 [NOG protein co-treated with trichostatin A co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of APPL2 mRNA CTD PMID:27188386 tert-butyl hydroperoxide decreases expression EXP 6480464 tert-Butylhydroperoxide results in decreased expression of APPL2 mRNA CTD PMID:15336504 tetrachloromethane multiple interactions ISO RGD:1563028 6480464 schizandrin B inhibits the reaction [Carbon Tetrachloride results in increased expression of APPL2 mRNA] CTD PMID:31150632 tetrachloromethane increases expression ISO RGD:1563028 6480464 Carbon Tetrachloride results in increased expression of APPL2 mRNA CTD PMID:31150632 tetraphene increases expression ISO RGD:1558154 6480464 benz(a)anthracene results in increased expression of APPL2 mRNA CTD PMID:26377693 thimerosal decreases expression EXP 6480464 Thimerosal results in decreased expression of APPL2 mRNA CTD PMID:27188386 titanium dioxide increases expression ISO RGD:1558154 6480464 titanium dioxide results in increased expression of APPL2 mRNA CTD PMID:23557971 trichloroethene increases methylation ISO RGD:1563028 6480464 Trichloroethylene results in increased methylation of APPL2 gene CTD PMID:27618143 trichostatin A decreases expression EXP 6480464 trichostatin A results in decreased expression of APPL2 mRNA CTD PMID:24935251 , PMID:26272509 trichostatin A multiple interactions EXP 6480464 [NOG protein co-treated with trichostatin A co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of APPL2 mRNA CTD PMID:27188386 troglitazone decreases expression ISO RGD:1558154 6480464 troglitazone results in decreased expression of APPL2 mRNA CTD PMID:28973697 valproic acid increases expression ISO RGD:1558154 6480464 Valproic Acid results in increased expression of APPL2 mRNA CTD PMID:21427059 valproic acid decreases expression EXP 6480464 Valproic Acid results in decreased expression of APPL2 mRNA CTD PMID:23179753 vorinostat decreases expression EXP 6480464 vorinostat results in decreased expression of APPL2 mRNA CTD PMID:27188386 
Gene-Chemical Interaction Annotations
