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Gene: APPL2 (adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2) Homo sapiens
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Symbol: APPL2
Name: adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2
Description: Exhibits phosphatidylinositol binding activity; phosphatidylserine binding activity; and protein homodimerization activity. Involved in several processes, including negative regulation of glucose import; protein homotetramerization; and protein import into nucleus. Localizes to the endosome membrane; nucleus; and plasma membrane.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: adapter protein containing PH domain, PTB domain and leucine zipper motif 2; adaptor protein containing PH domain, PTB domain and leucine zipper motif 2; adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2; DCC-interacting protein 13-beta; DIP13 beta; dip13-beta; DIP13B; FLJ10659
Orthologs:
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3812105,173,297 - 105,236,230 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh3712105,567,075 - 105,630,008 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3612104,091,205 - 104,154,138 (-)NCBINCBI36hg18NCBI36
Celera12105,231,366 - 105,294,273 (-)NCBI
Cytogenetic Map12q23.3NCBI
HuRef12102,626,453 - 102,689,404 (-)NCBIHuRef
CHM1_112105,532,775 - 105,595,738 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
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References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on APPL2
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1605653
Created: 2007-04-28
Species: Homo sapiens
Last Modified: 2019-11-26
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.