Tmeff2 (transmembrane protein with EGF like and two follistatin like domains 2) - Rat Genome Database

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Gene: Tmeff2 (transmembrane protein with EGF like and two follistatin like domains 2) Ictidomys tridecemlineatus
Analyze
Symbol: Tmeff2
Name: transmembrane protein with EGF like and two follistatin like domains 2
RGD ID: 12669072
Description: INVOLVED IN negative regulation of cell migration (ortholog); negative regulation of integrin biosynthetic process (ortholog); negative regulation of stress fiber assembly (ortholog); ASSOCIATED WITH Breast Neoplasms (ortholog); genetic disease (ortholog); Neurodevelopmental Disorders (ortholog); FOUND IN membrane (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: tomoregulin-2; transmembrane protein with EGF like and two follistatin like domains 2, transcript variant X1; transmembrane protein with EGF like and two follistatin like domains 2, transcript variant X2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: SpeTri2.0 - Squirrel SpeTri2.0 Assembly
Position:
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303150,461,820 - 150,724,361 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365066,114,108 - 6,355,200 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365066,113,521 - 6,375,986 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
membrane  (IEA)

Molecular Function

References
Additional References at PubMed
PMID:22301074  


Genomics

Comparative Map Data
Tmeff2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303150,461,820 - 150,724,361 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365066,114,108 - 6,355,200 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365066,113,521 - 6,375,986 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TMEFF2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382191,949,046 - 192,194,933 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2191,949,043 - 192,194,933 (-)EnsemblGRCh38hg38GRCh38
GRCh372192,813,772 - 193,059,659 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362192,522,988 - 192,767,889 (-)NCBINCBI36Build 36hg18NCBI36
Build 342192,640,254 - 192,885,150NCBI
Celera2186,409,789 - 186,655,054 (-)NCBICelera
Cytogenetic Map2q32.3NCBI
HuRef2184,672,895 - 184,920,068 (-)NCBIHuRef
CHM1_12192,820,711 - 193,065,780 (-)NCBICHM1_1
T2T-CHM13v2.02192,437,261 - 192,683,624 (-)NCBIT2T-CHM13v2.0
Tmeff2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39150,951,946 - 51,226,429 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl150,939,806 - 51,226,429 (+)EnsemblGRCm39 Ensembl
GRCm38150,900,683 - 51,187,270 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl150,900,647 - 51,187,270 (+)EnsemblGRCm38mm10GRCm38
MGSCv37150,984,367 - 51,244,114 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36150,872,068 - 51,131,815 (+)NCBIMGSCv36mm8
Celera151,227,901 - 51,485,691 (+)NCBICelera
Cytogenetic Map1C1.1NCBI
cM Map125.95NCBI
Tmeff2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8957,937,873 - 58,225,372 (-)NCBIGRCr8
mRatBN7.2950,445,947 - 50,733,473 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl950,436,079 - 50,733,475 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx958,992,474 - 59,279,503 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0964,115,319 - 64,402,348 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0962,411,281 - 62,698,306 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0955,379,130 - 55,673,704 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl955,384,100 - 55,673,829 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0955,079,810 - 55,369,414 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4947,519,306 - 47,811,472 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1947,522,306 - 47,812,884 (-)NCBI
Celera948,081,045 - 48,369,704 (-)NCBICelera
Cytogenetic Map9q22NCBI
Tmeff2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554037,121,834 - 7,354,908 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554037,122,019 - 7,353,769 (+)NCBIChiLan1.0ChiLan1.0
TMEFF2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21394,623,048 - 94,863,209 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B94,638,032 - 94,878,190 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B79,242,825 - 79,489,113 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B197,157,426 - 197,397,439 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B197,158,689 - 197,396,254 (-)Ensemblpanpan1.1panPan2
TMEFF2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1372,414,208 - 2,635,283 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl372,414,440 - 2,635,431 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha373,361,937 - 3,582,835 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0372,303,017 - 2,524,548 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl372,303,191 - 2,524,547 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1372,312,184 - 2,533,428 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0372,279,821 - 2,500,794 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0372,292,309 - 2,514,442 (-)NCBIUU_Cfam_GSD_1.0
TMEFF2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1596,594,970 - 96,855,743 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11596,594,901 - 96,856,848 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.215108,167,977 - 108,396,883 (-)NCBISscrofa10.2Sscrofa10.2susScr3
TMEFF2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11077,491,041 - 77,735,890 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1077,490,095 - 77,735,849 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666040121,733,118 - 121,975,654 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tmeff2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248544,021,094 - 4,250,812 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248544,021,022 - 4,249,757 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSSTOT00000012861   ⟹   ENSSTOP00000011526
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_0049365066,114,108 - 6,355,200 (+)Ensembl
RefSeq Acc Id: XM_005324358   ⟹   XP_005324415
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024405303150,483,080 - 150,724,361 (-)NCBI
SpeTri2.0NW_0049365066,113,521 - 6,355,052 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021725752   ⟹   XP_021581427
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024405303150,461,820 - 150,724,361 (-)NCBI
SpeTri2.0NW_0049365066,113,521 - 6,375,986 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_005324415 (Get FASTA)   NCBI Sequence Viewer  
  XP_021581427 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSSTOP00000011526.3
GenBank Protein KAG3274900 (Get FASTA)   NCBI Sequence Viewer  
  KAG3274901 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: XP_005324415   ⟸   XM_005324358
- Peptide Label: isoform X1
- UniProtKB: I3MJX8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_021581427   ⟸   XM_021725752
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: ENSSTOP00000011526   ⟸   ENSSTOT00000012861
Protein Domains
EGF-like   Kazal-like


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSTOG00000012859 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSSTOT00000012861.3 UniProtKB/TrEMBL
Gene3D-CATH 3.30.60.30 UniProtKB/TrEMBL
  Laminin UniProtKB/TrEMBL
InterPro EGF-like_dom UniProtKB/TrEMBL
  Kazal_dom UniProtKB/TrEMBL
  Kazal_dom_sf UniProtKB/TrEMBL
NCBI Gene Tmeff2 ENTREZGENE
PANTHER TRANSMEMBRANE PROTEIN WITH EGF LIKE AND TWO FOLLISTATIN LIKE DOMAINS 2 UniProtKB/TrEMBL
  UNCHARACTERIZED UniProtKB/TrEMBL
Pfam Kazal_2 UniProtKB/TrEMBL
PROSITE EGF_1 UniProtKB/TrEMBL
  EGF_2 UniProtKB/TrEMBL
  EGF_3 UniProtKB/TrEMBL
  KAZAL_2 UniProtKB/TrEMBL
SMART KAZAL UniProtKB/TrEMBL
Superfamily-SCOP EGF/Laminin UniProtKB/TrEMBL
  SSF100895 UniProtKB/TrEMBL
UniProt I3MJX8 ENTREZGENE, UniProtKB/TrEMBL