Csf1r<sup>tm(EGFP)Tset</sup> (colony stimulating factor 1 receptor; target mutant, Tset) - Rat Genome Database

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Gene: Csf1rtm(EGFP)Tset (colony stimulating factor 1 receptor; target mutant, Tset) Rattus norvegicus
Symbol: Csf1rtm(EGFP)Tset
Name: colony stimulating factor 1 receptor; target mutant, Tset
RGD ID: 126781692
Description: Targeting vector was designed to disrupt the first exon encoding of Csf1r gene with a drug selection cassette by homologous recombination in Rat ESC clone DAK31-C2. Sprague-Dawley females were used as embryo donors and pseudo-pregnant recipients.
ASSOCIATED WITH abnormal brain development; abnormal corpus callosum size; absent teeth; ASSOCIATED WITH bone development disease; infertility; lymphopenia
Type: allele  of Csf1r  
Previously known as: Csf1r^[tm(EGFP)Tset]
Is Marker For: Strains:   SD-Csf1rtm(EGFP)-/-/Tset   DA-Csf1rtm(EGFP)-/-/Hume   SD-Csf1rtm(EGFP)+/-/Tset   DA-Csf1rtm(EGFP)+/-/Hume  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position: No map positions available.


References - curated
# Reference Title Reference Citation
1. Analysis of homozygous and heterozygous Csf1r knockout in the rat as a model for understanding microglial function in brain development and the impacts of human CSF1R mutations. Patkar OL, etal., Neurobiol Dis. 2021 Apr;151:105268. doi: 10.1016/j.nbd.2021.105268. Epub 2021 Jan 12.
2. Pleiotropic Impacts of Macrophage and Microglial Deficiency on Development in Rats with Targeted Mutation of the Csf1r Locus. Pridans C, etal., J Immunol. 2018 Nov 1;201(9):2683-2699. doi: 10.4049/jimmunol.1701783. Epub 2018 Sep 24.


Related Rat Strains
The following Strains have been annotated to Csf1rtm(EGFP)Tset



Nucleotide Sequences

Additional Information