Klk1b9 (kallikrein 1-related peptidase b9) - Rat Genome Database

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Gene: Klk1b9 (kallikrein 1-related peptidase b9) Mus musculus
Analyze
No known orthologs.
Symbol: Klk1b9
Name: kallikrein 1-related peptidase b9
RGD ID: 1619278
MGI Page MGI
Description: Enables peptidase activity. Acts upstream of or within zymogen activation. Predicted to be located in several cellular components, including acrosomal vesicle; apical part of cell; and extracellular space. Predicted to be part of protein-containing complex. Predicted to be active in secretory granule. Is expressed in decidua; early conceptus; embryo; and salivary gland. Human ortholog(s) of this gene implicated in cardiomyopathy; chronic kidney disease; end stage renal disease; hypertension; and myocardial infarction. Orthologous to several human genes including KLK1 (kallikrein 1).
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: EGF-BP C; Egfbp; Egfbp-; Egfbp-3; Egfbp3; epidermal growth factor binding protein type C; epidermal growth factor-binding protein type C; glandular kallikrein K9; KAL; kallikrein; kallikrein 9; Klk; Klk9; mGk-9; tissue kallikrein-9
RGD Orthologs
Alliance Orthologs
More Info homologs ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39743,625,485 - 43,629,800 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl743,625,485 - 43,629,800 (+)EnsemblGRCm39 Ensembl
GRCm38743,976,061 - 43,980,376 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl743,976,061 - 43,980,376 (+)EnsemblGRCm38mm10GRCm38
MGSCv37751,231,431 - 51,235,746 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36743,844,103 - 43,848,418 (+)NCBIMGSCv36mm8
Celera739,436,989 - 39,441,304 (+)NCBICelera
Cytogenetic Map7B3NCBI
cM Map728.45NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:1460423   PMID:1918045   PMID:1981054   PMID:3036794   PMID:3322386   PMID:3322387   PMID:6602295   PMID:8452817   PMID:9507064   PMID:10456837   PMID:12437987   PMID:12466851  
PMID:12477932   PMID:15203212   PMID:15331780   PMID:15489334   PMID:16800724   PMID:21873635  


Genomics

Variants

.
Variants in Klk1b9
148 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:94
Count of miRNA genes:93
Interacting mature miRNAs:94
Transcripts:ENSMUST00000081399
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300722Sle3_msystemic lupus erythmatosus susceptibility 3 (mouse)Not determined7351172887142720Mouse
38501068Tip1_mtuberculosis immunophenotype 1, spleen CFU (mouse)7360299972549748Mouse
25314307Mlh1fc2_mMLH1 foci count 2 (mouse)76502999133501729Mouse
12792978Fbmd3_mfemoral bone mineral density 3, females only (mouse)77050288142367832Mouse
1357699Nhdlq6_mnon-HDL QTL 6 (mouse)Not determined7998886743988984Mouse
1558893Spir1_mStreptococcus pneumoniae infection resistance 1 (mouse)Not determined71030579844305936Mouse
10449139Eosn1_meosinophil differential 1 (mouse)71248087746480877Mouse
10449158Eosn3_meosinophil differential 3 (mouse)71248087746480877Mouse
4141566Femwf8_mfemur work to failure 8 (mouse)Not determined1303248547032621Mouse
11522751Cocia17_mcocaine-induced activity, QTL 17 (mouse)71313520447135204Mouse
25314314Sccor1_msynaptonemal complex length to mean MLH1 count ratio 1 (mouse)71333392547349748Mouse
1559016Drsi_mDCC-related Spp1 induction (mouse)Not determined71663729349159331Mouse
10412199Sst2_msusceptibility to tuberculosis 2 (mouse)Not determined718728794119485380Mouse
1301158Eae4_msusceptibility to experimental allergic encephalomyelitis 4 (mouse)Not determined719147398141919804Mouse
1301622Eae12_msusceptibility to experimental allergic encephalomyelitis 12 (mouse)Not determined71928001553280104Mouse
1301052Bhr6_mbronchial hyperresponsiveness 6 (mouse)Not determined71984225053842367Mouse
12904742Litsq2_mlitter size QTL 2 (mouse)72267388756674033Mouse
1301709Bdt4_mbone density traits 4 (mouse)Not determined72288857256888716Mouse
11354952Pdcc1_mplasmacytoid dentritic cell compartment 1 (mouse)72306653157066531Mouse
1301969Lbw5_mlupus NZB x NZW 5 (mouse)Not determined72684761560851775Mouse
12790989Tgl6_mtriglyceride 6 (mouse)72754054961540549Mouse
4141805Sle19_msystematic lupus erythematosus susceptibility 19 (mouse)Not determined3003248581135653Mouse
26884404Huml1_mhumerus length 1, 5 week (mouse)730199425108999207Mouse
1301175Ap7q_malcohol preference 7 QTL (mouse)Not determined73171484565715077Mouse
1300996Aorls2_maortic lesion size 2 (mouse)Not determined73239453266394681Mouse
4142003W3q10_mweight 3 weeks QTL 10 (mouse)Not determined3349772758148965Mouse
4142102Tailq5_mtail length QTL 5 (mouse)Not determined3349772758148965Mouse
4142218W6q17_mweight 6 weeks QTL 17 (mouse)Not determined3349772758148965Mouse
4141909W10q18_mweight 10 weeks QTL 18 (mouse)Not determined3349772758148965Mouse
1357883Epfq5_mepididymal fat pad weight QTL 5 (mouse)Not determined73349772758148965Mouse
1357634Splq7_mspleen weight QTL 7 (mouse)Not determined73349772758148965Mouse
39128210Lwq19_mliver weight QTL 19 (mouse)73349772758148965Mouse
1357469Kidq5_mkidney weight QTL 5 (mouse)Not determined73349772758148965Mouse
1559000Ossc1_mosteosarcoma susceptibility 1 (mouse)Not determined73405302568053223Mouse
38501071Stsl6_mSalmonella typhimurium susceptibility locus 6 (mouse)73419942551149748Mouse
10045622Heal20_mwound healing/regeneration 20 (mouse)Not determined73431688768317043Mouse
1357586Mdmsc3_mmodifier of muscularity 3 (mouse)Not determined73444786968448018Mouse
1301514Rigs1_mradiation induced gastroschisis 1 (mouse)Not determined73628001592394346Mouse
1301082Bbaa16_mB.burgdorferi-associated arthritis 16 (mouse)Not determined736280015116416877Mouse
25314301Vmm3_mvariable multisystem mineralization 3, lung (mouse)73729942572049748Mouse
25314303Vmm4_mvariable multisystem mineralization 4, kidney (mouse)73729942587049208Mouse
1300878Skts1_mskin tumor susceptibility 1 (mouse)Not determined73789138671891582Mouse
10402488Dipa2_mdrug induced psychomotor activation 2 (mouse)Not determined73842154872421684Mouse
1300791Abbp3_mA/J and C57BL/6 blood pressure 3 (mouse)Not determined739673887103510010Mouse
11252140Fdr1_mfat response to dietary restriction 1 (mouse)74114882075148965Mouse
4141929Chlq18_mcirculating hormone level QTL 18 (mouse)Not determined74114882075148965Mouse

Markers in Region
33.MMHAP81FRC12.seq  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38743,977,423 - 43,977,604UniSTSGRCm38
GRCm38743,968,085 - 43,968,266UniSTSGRCm38
MGSCv37751,223,455 - 51,223,636UniSTSGRCm37
MGSCv37751,232,793 - 51,232,974UniSTSGRCm37
Celera739,427,413 - 39,427,594UniSTS
Celera739,438,351 - 39,438,532UniSTS
Cytogenetic Map7B4UniSTS
cM Map723.18UniSTS
cM Map723.1UniSTS
Whitehead_YAC7 UniSTS
Klk9  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map7B4UniSTS
cM Map723.18UniSTS
cM Map723.0UniSTS
Ngfa  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map7B4UniSTS
cM Map723.02UniSTS
cM Map723.0UniSTS


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000081399   ⟹   ENSMUSP00000080133
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl743,625,485 - 43,629,800 (+)Ensembl
GRCm38.p6 Ensembl743,976,061 - 43,980,376 (+)Ensembl
RefSeq Acc Id: NM_010116   ⟹   NP_034246
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39743,625,485 - 43,629,800 (+)NCBI
GRCm38743,976,061 - 43,980,376 (+)ENTREZGENE
MGSCv37751,231,431 - 51,235,746 (+)RGD
Celera739,436,989 - 39,441,304 (+)RGD
cM Map7 ENTREZGENE
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_034246   ⟸   NM_010116
- Peptide Label: preproprotein
- UniProtKB: P15949 (UniProtKB/Swiss-Prot),   A0A1R3UFA0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000080133   ⟸   ENSMUST00000081399
Protein Domains
Peptidase S1

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P15949-F1-model_v2 AlphaFold P15949 1-261 view protein structure

Promoters
RGD ID:8663821
Promoter ID:EPDNEW_M9941
Type:multiple initiation site
Name:Klk1b9_1
Description:Mus musculus kallikrein 1-related peptidase b9 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38743,976,055 - 43,976,115EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:95293 AgrOrtholog
Ensembl Genes ENSMUSG00000059042 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000081399 ENTREZGENE
  ENSMUST00000081399.4 UniProtKB/Swiss-Prot
Gene3D-CATH 2.40.10.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Peptidase_S1_PA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_S1_PA_chymotrypsin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_S1A UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Trypsin_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRYPSIN_HIS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRYPSIN_SER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:13648 UniProtKB/Swiss-Prot
MGD MGI:95293 ENTREZGENE
NCBI Gene 13648 ENTREZGENE
PANTHER KALLIKREIN-1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  KALLIKREIN-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Trypsin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Klk1b9 PhenoGen
PRINTS CHYMOTRYPSIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE TRYPSIN_DOM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRYPSIN_HIS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRYPSIN_SER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART Tryp_SPc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF50494 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A1R3UFA0 ENTREZGENE, UniProtKB/TrEMBL
  K1KB9_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE