Scube3 (signal peptide, CUB domain, EGF-like 3) - Rat Genome Database

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Gene: Scube3 (signal peptide, CUB domain, EGF-like 3) Mus musculus
Analyze
Symbol: Scube3
Name: signal peptide, CUB domain, EGF-like 3
RGD ID: 1614840
MGI Page MGI
Description: Predicted to enable BMP binding activity; BMP receptor binding activity; and identical protein binding activity. Involved in positive regulation of osteoblast differentiation. Acts upstream of or within positive regulation of smoothened signaling pathway. Predicted to be located in plasma membrane. Predicted to be active in cell surface and extracellular space. Is expressed in several structures, including embryo ectoderm; embryo mesenchyme; integumental system; jaw; and sensory organ. Human ortholog(s) of this gene implicated in short stature, facial dysmorphism, and skeletal anomalies with or without cardiac anomalies 2. Orthologous to human SCUBE3 (signal peptide, CUB domain and EGF like domain containing 3).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: CEGF3; D030038I21Rik; signal peptide, CUB and EGF-like domain containing protein 3; signal peptide, CUB and EGF-like domain-containing protein 3
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Related Pseudogenes: Gm12014  
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391728,361,074 - 28,393,825 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1728,361,115 - 28,393,828 (+)EnsemblGRCm39 Ensembl
GRCm381728,142,100 - 28,174,851 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1728,142,141 - 28,174,854 (+)EnsemblGRCm38mm10GRCm38
MGSCv371728,279,471 - 28,308,290 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361727,870,115 - 27,898,934 (+)NCBIMGSCv36mm8
Celera1728,705,823 - 28,724,769 (+)NCBICelera
Cytogenetic Map17A3.3NCBI
cM Map1714.63NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal anxiety-related response  (IAGP)
abnormal body composition  (IAGP)
abnormal bone ossification  (IAGP)
abnormal digit morphology  (IAGP)
abnormal enzyme/coenzyme activity  (IAGP)
abnormal food intake  (IAGP)
abnormal inner ear morphology  (IAGP)
abnormal interventricular septum morphology  (IAGP)
abnormal lumbar vertebrae morphology  (IAGP)
abnormal malleus head morphology  (IAGP)
abnormal malleus morphology  (IAGP)
abnormal metacarpal bone morphology  (IAGP)
abnormal metatarsal bone morphology  (IAGP)
abnormal middle ear morphology  (IAGP)
abnormal middle ear ossicle morphology  (IAGP)
abnormal pectoral girdle bone morphology  (IAGP)
abnormal posture  (IAGP)
abnormal renal filtration  (IAGP)
abnormal tarsal bone morphology  (IAGP)
abnormal temporal bone morphology  (IAGP)
abnormal thoracic vertebrae morphology  (IAGP)
abnormal vertebral column morphology  (IAGP)
abnormal vertebral pedicle morphology  (IAGP)
conductive hearing loss  (IAGP)
decreased body fat mass  (IAGP)
decreased body size  (IAGP)
decreased bone mineral content  (IAGP)
decreased bone mineral density  (IAGP)
decreased circulating cholesterol level  (IAGP)
decreased circulating free fatty acids level  (IAGP)
decreased circulating glucose level  (IAGP)
decreased circulating glycerol level  (IAGP)
decreased circulating phosphate level  (IAGP)
decreased circulating serum albumin level  (IAGP)
decreased circulating total protein level  (IAGP)
decreased circulating triglyceride level  (IAGP)
decreased grip strength  (IAGP)
decreased heart left ventricle posterior wall thickness  (IAGP)
decreased heart left ventricle weight  (IAGP)
decreased lean body mass  (IAGP)
decreased locomotor activity  (IAGP)
decreased pulmonary respiratory rate  (IAGP)
decreased urine albumin level  (IAGP)
decreased urine creatinine level  (IAGP)
decreased urine glucose level  (IAGP)
decreased urine protein level  (IAGP)
decreased urine uric acid level  (IAGP)
decreased vertical activity  (IAGP)
fused phalanges  (IAGP)
improved glucose tolerance  (IAGP)
increased alkaline phosphatase activity  (IAGP)
increased blood urea nitrogen level  (IAGP)
increased blood uric acid level  (IAGP)
increased bone resorption  (IAGP)
increased circulating calcium level  (IAGP)
increased circulating creatinine level  (IAGP)
increased circulating potassium level  (IAGP)
increased fluid intake  (IAGP)
increased or absent threshold for auditory brainstem response  (IAGP)
kinked tail  (IAGP)
kyphosis  (IAGP)
no abnormal phenotype detected  (IAGP)
polyuria  (IAGP)
prolonged QRS complex duration  (IAGP)
rib fusion  (IAGP)
short femur  (IAGP)
short tail  (IAGP)
small incus  (IAGP)
small middle ear ossicles  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. Mouse MP Annotation Import Pipeline RGD automated import pipeline
2. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12466851   PMID:12477932   PMID:14610273   PMID:15234972   PMID:15489334   PMID:16141072   PMID:16141073   PMID:17258941  
PMID:19906978   PMID:20957652   PMID:21873635   PMID:23383134   PMID:24849601   PMID:25639508   PMID:27815347   PMID:28515211   PMID:32325033   PMID:33308444   PMID:34142127   PMID:35777353  
PMID:37189178  


Genomics

Comparative Map Data
Scube3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391728,361,074 - 28,393,825 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1728,361,115 - 28,393,828 (+)EnsemblGRCm39 Ensembl
GRCm381728,142,100 - 28,174,851 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1728,142,141 - 28,174,854 (+)EnsemblGRCm38mm10GRCm38
MGSCv371728,279,471 - 28,308,290 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361727,870,115 - 27,898,934 (+)NCBIMGSCv36mm8
Celera1728,705,823 - 28,724,769 (+)NCBICelera
Cytogenetic Map17A3.3NCBI
cM Map1714.63NCBI
SCUBE3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38635,213,956 - 35,253,079 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl635,213,956 - 35,253,079 (+)EnsemblGRCh38hg38GRCh38
GRCh37635,181,733 - 35,220,856 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36635,290,168 - 35,326,587 (+)NCBINCBI36Build 36hg18NCBI36
Build 34635,290,167 - 35,326,587NCBI
Celera636,736,150 - 36,772,575 (+)NCBICelera
Cytogenetic Map6p21.31NCBI
HuRef634,902,836 - 34,939,819 (+)NCBIHuRef
CHM1_1635,184,282 - 35,220,692 (+)NCBICHM1_1
T2T-CHM13v2.0635,037,034 - 35,076,159 (+)NCBIT2T-CHM13v2.0
Scube3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8206,200,891 - 6,232,848 (+)NCBIGRCr8
mRatBN7.2206,199,182 - 6,231,100 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl206,199,182 - 6,228,584 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx206,912,395 - 6,940,445 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0206,274,217 - 6,302,268 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0206,753,791 - 6,781,853 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0207,718,260 - 7,749,847 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl207,718,282 - 7,746,331 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0209,931,806 - 9,950,181 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.1206,388,935 - 6,408,001 (+)NCBI
Celera207,757,793 - 7,786,060 (+)NCBICelera
Cytogenetic Map20p12NCBI
Scube3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554373,178,985 - 3,213,772 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554373,178,985 - 3,213,772 (+)NCBIChiLan1.0ChiLan1.0
SCUBE3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2549,675,914 - 49,724,091 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1645,550,951 - 45,586,182 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0634,776,605 - 34,815,808 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1635,872,590 - 35,911,272 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl635,872,590 - 35,911,272 (+)Ensemblpanpan1.1panPan2
SCUBE3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1124,383,649 - 4,420,844 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl124,382,916 - 4,418,300 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha124,400,341 - 4,437,257 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0124,722,195 - 4,759,130 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl124,722,222 - 4,755,184 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1124,381,129 - 4,418,047 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0124,462,402 - 4,499,312 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0124,562,355 - 4,599,276 (+)NCBIUU_Cfam_GSD_1.0
Scube3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494639,961,825 - 39,997,194 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647623,966,847 - 23,998,663 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647623,962,956 - 23,987,629 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SCUBE3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl731,114,082 - 31,150,000 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1731,113,596 - 31,153,095 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2735,987,533 - 36,009,071 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SCUBE3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11736,871,032 - 36,910,583 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1736,875,410 - 36,910,091 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604435,124,510 - 35,164,263 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Scube3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475422,166,578 - 22,196,540 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475422,164,319 - 22,196,569 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Scube3
15 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:2415
Count of miRNA genes:886
Interacting mature miRNAs:1197
Transcripts:ENSMUST00000043503, ENSMUST00000132670, ENSMUST00000137147, ENSMUST00000142170, ENSMUST00000148342
Prediction methods:Miranda, Pita, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
10045977Tir9_mtrypanosome infection response 9 (mouse)Not determined172787811943885114Mouse
12910528Nrq1_mnoise-induced hearing loss resistant QTL 1 (mouse)17129198453Mouse
1302038Radpf1_mradiation pulmonary fibrosis 1 (mouse)Not determined171683545533819843Mouse
1300890Bhr3_mbronchial hyperresponsiveness 3 (mouse)Not determined17397489048866091Mouse
12904013Cfq12_mconditioned fear QTL 12 (mouse)172682878130664955Mouse
11075105Modc1_mmodifier of Odc1 (mouse)172771579245622654Mouse
1300995Fembrs4_mfemur breaking strength 4 (mouse)Not determined171506165249061760Mouse
15039348Nmrs37_mNAFLD-associated magnetic resonance shift 37 (mouse)172781520961815209Mouse
4141608Phl1_mprogressive hearing loss 1 (mouse)Not determined17787584329487423Mouse
1302152Skull25_mskull morphology 25 (mouse)Not determined171681972150819843Mouse
1302028Asbb3_mautoimmune susceptibility in C57BL/6J and BALB/c 3 (mouse)Not determined171087811944878219Mouse
15039354Nmrs36_mNAFLD-associated magnetic resonance shift 36 (mouse)171914502553145025Mouse
4141215Mnic1_mmacronutrient intake, carbohydrate 1 (mouse)Not determined485475245670266Mouse
1300787Cd8mts5_mCD8 memory T cell subset 5 (mouse)Not determined17858491442585149Mouse
13524847Asrq8a_macoustic startle response 8a (mouse)171264696146646961Mouse
1300914Pcir4_mperiosteal circumference 4 (mouse)Not determined171506165249061760Mouse
13452396Leusq3_mleucocytosis susceptibility QTL 3 (mouse)171746220851462345Mouse
13452399Leusq6_mleucocytosis susceptibility QTL 6 (mouse)171746220851462345Mouse
1300535Char3_mP. chabaudi malaria resistance QTL 3 (mouse)Not determined171746220851462345Mouse
1302070Tbbmd7_mtotal body bone mineral density 7 (mouse)Not determined171506165249061760Mouse
10412214Sxbq3_mSGC/Knj cross B6 QTL 3 (mouse)Not determined171746220851462345Mouse
10412083Sm2_msusceptibility to Schistosoma mansoni infection 2 (mouse)Not determined171702994351030078Mouse
10412204Bbaa29_mB.burgdorferi-associated arthritis 29 (mouse)Not determined172605118560051352Mouse
10043949Pbft7_mpercent body fat 7 (mouse)Not determined17689393640893936Mouse
4141067Hbnr2_mHeligmosomoides bakeri nematode resistance 2 (mouse)Not determined1188597145886119Mouse
12904946Tammq8_mtibialis anterior muscle mass QTL 8 (mouse)171245178746451787Mouse
10412198Sst5_msusceptibility to tuberculosis 5 (mouse)Not determined172507658355712970Mouse
4142342Lfnq4_mlung function QTL 4 (mouse)Not determined1120648439364059Mouse
10412196Bbaa28_mB.burgdorferi-associated arthritis 28 (mouse)Not determined172558491443976235Mouse
1301935Skull24_mskull morphology 24 (mouse)Not determined17858491442585149Mouse
13524851Asrq8_macoustic startle response 8 (mouse)17131030170Mouse
1301331Lbw1_mlupus NZB x NZW 1 (mouse)Not determined171841835752420983Mouse
1301840Ssial4_msusceptibility to sialadenitiss 4 (mouse)Not determined171817541252178214Mouse
1302100Circp2_mcircadian photosensitivity 2 (mouse)Not determined17129198453Mouse
1357789Kdnw3_mkidney weight 3 (mouse)Not determined17485475247885665Mouse
1301338Lmr1_mleishmaniasis resistance 1 (mouse)Not determined171008134086996400Mouse
1301056Pas2_mpulmonary adenoma susceptibility 2 (mouse)Not determined171842214152424327Mouse
1301454Eae5_msusceptibility to experimental allergic encephalomyelitis 5 (mouse)Not determined172461275058612864Mouse
14747010Mancz14_mmandible centroid size 14 (mouse)171199818445998184Mouse
1302005Loco2_mlocomotor activity 2 (mouse)Not determined172688497260885114Mouse
4141272Tfv1_mtotal food volume 1 (mouse)Not determined485475265637357Mouse
1300602Eye2_meye weight 2 (mouse)Not determined172650533741105037Mouse
10412276Leci2_mleukocyte endothelial cell interactions 2 (mouse)Not determined17334817537348299Mouse
1302140Wta4_mweight adult 4 (mouse)Not determined171681972150819843Mouse
1300706Alan1_malloantigen response 1 (mouse)Not determined17485475246469702Mouse
1558886Lgth9_mbody length 9 (mouse)Not determined171506165249061760Mouse
1558758Kcal2_mkilocalorie 2 (mouse)Not determined172640101252911704Mouse
12903990Opfaq5_mopen field activity QTL 5 (mouse)172595092528992098Mouse
4142150Stheal11_msoft tissue heal 11 (mouse)Not determined171228621183361768Mouse
11081168Tir7_mtrypanosome infection response 7 (mouse)171412337248123496Mouse
12910527Nrq1a_mnoise-induced hearing loss resistant QTL 1a (mouse)17129198453Mouse

Markers in Region
RH144156  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381728,147,564 - 28,147,671UniSTSGRCm38
MGSCv371728,284,509 - 28,284,616UniSTSGRCm37
Celera1728,700,993 - 28,701,100UniSTS
Cytogenetic Map17A3.3UniSTS


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSMUST00000043503   ⟹   ENSMUSP00000038366
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1728,361,115 - 28,393,828 (+)Ensembl
GRCm38.p6 Ensembl1728,142,141 - 28,174,854 (+)Ensembl
Ensembl Acc Id: ENSMUST00000132670   ⟹   ENSMUSP00000117490
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1728,361,500 - 28,389,119 (+)Ensembl
GRCm38.p6 Ensembl1728,142,526 - 28,170,145 (+)Ensembl
Ensembl Acc Id: ENSMUST00000137147   ⟹   ENSMUSP00000156515
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1728,361,500 - 28,391,111 (+)Ensembl
GRCm38.p6 Ensembl1728,142,526 - 28,172,137 (+)Ensembl
Ensembl Acc Id: ENSMUST00000142170
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1728,384,783 - 28,386,625 (+)Ensembl
GRCm38.p6 Ensembl1728,165,809 - 28,167,651 (+)Ensembl
Ensembl Acc Id: ENSMUST00000148342
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1728,379,735 - 28,392,001 (+)Ensembl
GRCm38.p6 Ensembl1728,160,761 - 28,173,027 (+)Ensembl
Ensembl Acc Id: ENSMUST00000232984
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1728,377,848 - 28,383,084 (+)Ensembl
GRCm38.p6 Ensembl1728,158,874 - 28,164,110 (+)Ensembl
Ensembl Acc Id: ENSMUST00000233905   ⟹   ENSMUSP00000156885
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1728,361,292 - 28,390,916 (+)Ensembl
GRCm38.p6 Ensembl1728,142,318 - 28,171,942 (+)Ensembl
RefSeq Acc Id: NM_001004366   ⟹   NP_001004366
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391728,361,283 - 28,393,819 (+)NCBI
GRCm381728,142,309 - 28,174,845 (+)NCBI
MGSCv371728,279,471 - 28,308,290 (+)RGD
Celera1728,705,823 - 28,724,769 (+)RGD
cM Map17 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_001368734   ⟹   NP_001355663
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391728,361,283 - 28,375,408 (+)NCBI
GRCm381728,142,309 - 28,156,434 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006524323   ⟹   XP_006524386
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391728,361,074 - 28,393,825 (+)NCBI
GRCm381728,142,100 - 28,174,851 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006524324   ⟹   XP_006524387
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391728,361,074 - 28,393,825 (+)NCBI
GRCm381728,142,100 - 28,174,851 (+)NCBI
Sequence:
RefSeq Acc Id: XM_030249829   ⟹   XP_030105689
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391728,361,074 - 28,393,825 (+)NCBI
GRCm381728,142,100 - 28,174,851 (+)NCBI
Sequence:
RefSeq Acc Id: NP_001004366   ⟸   NM_001004366
- Peptide Label: isoform 1 precursor
- UniProtKB: B2KF22 (UniProtKB/Swiss-Prot),   Q68FG9 (UniProtKB/Swiss-Prot),   Q66PY1 (UniProtKB/Swiss-Prot),   A0A3B2W867 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006524386   ⟸   XM_006524323
- Peptide Label: isoform X1
- UniProtKB: A0A3B2WCG9 (UniProtKB/TrEMBL),   A0A3B2W867 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006524387   ⟸   XM_006524324
- Peptide Label: isoform X2
- UniProtKB: A0A3B2W867 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_030105689   ⟸   XM_030249829
- Peptide Label: isoform X3
- UniProtKB: A0A3B2W867 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001355663   ⟸   NM_001368734
- Peptide Label: isoform 2 precursor
Ensembl Acc Id: ENSMUSP00000117490   ⟸   ENSMUST00000132670
Ensembl Acc Id: ENSMUSP00000156885   ⟸   ENSMUST00000233905
Ensembl Acc Id: ENSMUSP00000156515   ⟸   ENSMUST00000137147
Ensembl Acc Id: ENSMUSP00000038366   ⟸   ENSMUST00000043503
Protein Domains
CUB   EGF-like

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q66PY1-F1-model_v2 AlphaFold Q66PY1 1-993 view protein structure

Promoters
RGD ID:13675326
Promoter ID:EPDNEW_M21812
Type:single initiation site
Name:Scube3_1
Description:Mus musculus signal peptide, CUB domain, EGF-like 3 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381728,142,569 - 28,142,629EPDNEW
RGD ID:6828657
Promoter ID:MM_KWN:22840
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Brain,   Lung
Transcripts:OTTMUST00000049726
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361728,297,616 - 28,298,116 (+)MPROMDB
RGD ID:6828660
Promoter ID:MM_KWN:22841
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Brain,   Spleen
Transcripts:OTTMUST00000049735
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361728,301,916 - 28,302,617 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:3045253 AgrOrtholog
Ensembl Genes ENSMUSG00000038677 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000043503 ENTREZGENE
  ENSMUST00000043503.11 UniProtKB/Swiss-Prot
  ENSMUST00000132670 ENTREZGENE
  ENSMUST00000132670.3 UniProtKB/Swiss-Prot
  ENSMUST00000137147 ENTREZGENE
  ENSMUST00000137147.9 UniProtKB/TrEMBL
  ENSMUST00000233905.2 UniProtKB/TrEMBL
Gene3D-CATH 2.60.120.290 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Laminin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tumor Necrosis Factor Receptor, subunit A, domain 2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro cEGF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CUB_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF-like_Ca-bd_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF-like_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF-type_Asp/Asn_hydroxyl_site UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_Ca-bd_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Growth_fac_rcpt_cys_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NOTCH1_EGF-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SCUB_EGF-like_domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Sperma_CUB_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tyr-kin_ephrin_A/B_rcpt-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:268935 UniProtKB/Swiss-Prot
MGD MGI:3045253 ENTREZGENE
NCBI Gene 268935 ENTREZGENE
PANTHER SIGNAL PEPTIDE, CUB AND EGF-LIKE DOMAIN-CONTAINING UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SIGNAL PEPTIDE, CUB AND EGF-LIKE DOMAIN-CONTAINING PROTEIN 3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam cEGF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CUB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_CA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ephrin_rec_like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FXa_inhibition UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Scube3 PhenoGen
PROSITE ASX_HYDROXYL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CUB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_CA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART CUB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_CA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ephrin_rec_like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP EGF/Laminin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF49854 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF57184 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A3B2W867 ENTREZGENE, UniProtKB/TrEMBL
  A0A3B2WCG9 ENTREZGENE, UniProtKB/TrEMBL
  B2KF22 ENTREZGENE
  Q66PY1 ENTREZGENE
  Q68FG9 ENTREZGENE
  SCUB3_MOUSE UniProtKB/Swiss-Prot
UniProt Secondary B2KF22 UniProtKB/Swiss-Prot
  Q68FG9 UniProtKB/Swiss-Prot