MFGE8 (milk fat globule EGF and factor V/VIII domain containing) - Rat Genome Database

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Gene: MFGE8 (milk fat globule EGF and factor V/VIII domain containing) Canis lupus familiaris
Analyze
Symbol: MFGE8
Name: milk fat globule EGF and factor V/VIII domain containing
RGD ID: 12175263
Description: ENCODES a protein that exhibits integrin binding (inferred); phosphatidylserine binding (inferred); INVOLVED IN positive regulation of cell population proliferation (ortholog); response to estrogen (ortholog); ASSOCIATED WITH Bloom syndrome (ortholog); Breast Neoplasms (ortholog); colorectal cancer (ortholog); FOUND IN external side of plasma membrane (inferred); extracellular region (inferred); extracellular space (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: lactadherin
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1352,054,243 - 52,064,423 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl352,054,831 - 52,080,240 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha354,690,614 - 54,716,666 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0352,473,179 - 52,499,328 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl352,452,939 - 52,499,723 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1351,995,688 - 52,008,715 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0352,206,149 - 52,232,464 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0352,544,955 - 52,571,161 (-)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:10967132  


Genomics

Comparative Map Data
MFGE8
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1352,054,243 - 52,064,423 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl352,054,831 - 52,080,240 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha354,690,614 - 54,716,666 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0352,473,179 - 52,499,328 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl352,452,939 - 52,499,723 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1351,995,688 - 52,008,715 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0352,206,149 - 52,232,464 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0352,544,955 - 52,571,161 (-)NCBIUU_Cfam_GSD_1.0
MFGE8
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381588,898,683 - 88,913,379 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1588,898,683 - 88,913,468 (-)EnsemblGRCh38hg38GRCh38
GRCh371589,441,914 - 89,456,610 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361587,242,920 - 87,257,614 (-)NCBINCBI36Build 36hg18NCBI36
Build 341587,242,919 - 87,257,614NCBI
Celera1565,843,230 - 65,857,979 (-)NCBICelera
Cytogenetic Map15q26.1NCBI
HuRef1565,554,125 - 65,568,874 (-)NCBIHuRef
CHM1_11589,282,553 - 89,297,281 (-)NCBICHM1_1
T2T-CHM13v2.01586,653,326 - 86,668,022 (-)NCBIT2T-CHM13v2.0
Mfge8
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39778,783,516 - 78,798,808 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl778,783,516 - 78,798,808 (-)EnsemblGRCm39 Ensembl
GRCm38779,133,768 - 79,149,060 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl779,133,768 - 79,149,060 (-)EnsemblGRCm38mm10GRCm38
MGSCv37786,278,654 - 86,293,946 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36779,007,282 - 79,022,526 (-)NCBIMGSCv36mm8
Celera776,533,114 - 76,548,369 (-)NCBICelera
Cytogenetic Map7D2NCBI
cM Map744.9NCBI
Mfge8
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81142,474,027 - 142,489,431 (-)NCBIGRCr8
mRatBN7.21133,064,665 - 133,080,069 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1133,064,665 - 133,080,073 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1140,981,391 - 140,996,820 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01148,150,820 - 148,166,249 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01141,068,501 - 141,083,927 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01140,845,478 - 140,860,882 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1140,845,465 - 140,860,894 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01141,814,239 - 141,829,653 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41134,870,029 - 134,885,431 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11134,948,377 - 134,963,734 (-)NCBI
Celera1125,135,501 - 125,150,920 (-)NCBICelera
Cytogenetic Map1q31NCBI
Mfge8
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541616,091,684 - 16,103,768 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541616,092,263 - 16,103,097 (+)NCBIChiLan1.0ChiLan1.0
MFGE8
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21678,443,008 - 78,457,892 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11582,147,570 - 82,162,307 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01567,587,360 - 67,602,029 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11586,795,135 - 86,809,876 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1586,795,135 - 86,809,876 (-)Ensemblpanpan1.1panPan2
Mfge8
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640131,453,939 - 131,466,312 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648314,865,033 - 14,880,794 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493648314,868,171 - 14,880,552 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MFGE8
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl754,539,970 - 54,571,747 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1754,539,970 - 54,554,885 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2759,504,870 - 59,518,390 (-)NCBISscrofa10.2Sscrofa10.2susScr3
MFGE8
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Vero_WHO_p1.0NW_02366605939,380,185 - 39,394,880 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mfge8
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476816,173,430 - 16,184,521 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476816,173,546 - 16,184,450 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in MFGE8
155 total Variants

Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
reproductive system
respiratory system
6 5 5 23 22 16 6 6 6 6 33 22 12 14 10

Sequence

Nucleotide Sequences
RefSeq Transcripts XM_022416924 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038471887 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038474789 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038474798 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038474807 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038532810 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038532811 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038532812 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038597134 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038597135 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038597136 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038661316 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038661317 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038661318 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AAEX04000003 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ222747 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAHUQ010000045 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAQRD010000074 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAUVH010000011 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  REHQ01000003 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSCAFT00000018357   ⟹   ENSCAFP00000017002
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl352,054,831 - 52,064,689 (-)Ensembl
Ensembl Acc Id: ENSCAFT00000062830   ⟹   ENSCAFP00000058578
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl352,054,831 - 52,064,773 (-)Ensembl
Ensembl Acc Id: ENSCAFT00000071417   ⟹   ENSCAFP00000050234
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl352,054,831 - 52,080,240 (-)Ensembl
Ensembl Acc Id: ENSCAFT00000079935   ⟹   ENSCAFP00000048820
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl352,054,831 - 52,065,011 (-)Ensembl
Ensembl Acc Id: ENSCAFT00000093612   ⟹   ENSCAFP00000051630
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl352,054,885 - 52,064,689 (-)Ensembl
Ensembl Acc Id: ENSCAFT00845006757   ⟹   ENSCAFP00845005373
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl352,452,939 - 52,486,148 (-)Ensembl
Ensembl Acc Id: ENSCAFT00845006765   ⟹   ENSCAFP00845005380
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl352,452,939 - 52,470,083 (-)Ensembl
Ensembl Acc Id: ENSCAFT00845006768   ⟹   ENSCAFP00845005382
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl352,473,182 - 52,499,723 (-)Ensembl
RefSeq Acc Id: XM_038471887   ⟹   XP_038327815
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1351,995,688 - 52,008,715 (-)NCBI
RefSeq Acc Id: XM_038474789   ⟹   XP_038330717
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
Dog10K_Boxer_Tasha354,690,614 - 54,703,448 (-)NCBI
RefSeq Acc Id: XM_038474798   ⟹   XP_038330726
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
Dog10K_Boxer_Tasha354,690,614 - 54,703,448 (-)NCBI
RefSeq Acc Id: XM_038474807   ⟹   XP_038330735
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
Dog10K_Boxer_Tasha354,690,614 - 54,716,666 (-)NCBI
RefSeq Acc Id: XM_038532810   ⟹   XP_038388738
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0352,544,955 - 52,557,990 (-)NCBI
RefSeq Acc Id: XM_038532811   ⟹   XP_038388739
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0352,544,955 - 52,557,990 (-)NCBI
RefSeq Acc Id: XM_038532812   ⟹   XP_038388740
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0352,544,955 - 52,571,161 (-)NCBI
RefSeq Acc Id: XM_038597134   ⟹   XP_038453062
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0352,206,149 - 52,219,278 (-)NCBI
RefSeq Acc Id: XM_038597135   ⟹   XP_038453063
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0352,206,149 - 52,219,278 (-)NCBI
RefSeq Acc Id: XM_038597136   ⟹   XP_038453064
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0352,206,149 - 52,232,464 (-)NCBI
RefSeq Acc Id: XM_038661316   ⟹   XP_038517244
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0352,473,179 - 52,486,156 (-)NCBI
RefSeq Acc Id: XM_038661317   ⟹   XP_038517245
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0352,473,179 - 52,486,156 (-)NCBI
RefSeq Acc Id: XM_038661318   ⟹   XP_038517246
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0352,473,179 - 52,499,328 (-)NCBI
Ensembl Acc Id: ENSCAFP00000051630   ⟸   ENSCAFT00000093612
Ensembl Acc Id: ENSCAFP00000058578   ⟸   ENSCAFT00000062830
Ensembl Acc Id: ENSCAFP00000017002   ⟸   ENSCAFT00000018357
Ensembl Acc Id: ENSCAFP00000048820   ⟸   ENSCAFT00000079935
Ensembl Acc Id: ENSCAFP00000050234   ⟸   ENSCAFT00000071417
RefSeq Acc Id: XP_038327815   ⟸   XM_038471887
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038453064   ⟸   XM_038597136
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038453063   ⟸   XM_038597135
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038453062   ⟸   XM_038597134
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038517246   ⟸   XM_038661318
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038517245   ⟸   XM_038661317
- Peptide Label: isoform X2
- UniProtKB: A0A8I3RT41 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038517244   ⟸   XM_038661316
- Peptide Label: isoform X1
- UniProtKB: A0A8I3RT41 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038330735   ⟸   XM_038474807
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038330726   ⟸   XM_038474798
- Peptide Label: isoform X2
- UniProtKB: A0A8P0P7S2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038330717   ⟸   XM_038474789
- Peptide Label: isoform X1
- UniProtKB: A0A8P0P7S2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038388740   ⟸   XM_038532812
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038388739   ⟸   XM_038532811
- Peptide Label: isoform X2
- UniProtKB: A0A8P0P7S2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038388738   ⟸   XM_038532810
- Peptide Label: isoform X1
- UniProtKB: A0A8C0L2C7 (UniProtKB/TrEMBL),   A0A8C0M951 (UniProtKB/TrEMBL),   A0A8C0Q310 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSCAFP00845005380   ⟸   ENSCAFT00845006765
Ensembl Acc Id: ENSCAFP00845005373   ⟸   ENSCAFT00845006757
Ensembl Acc Id: ENSCAFP00845005382   ⟸   ENSCAFT00845006768
Protein Domains
EGF-like   F5/8 type C


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000011542 UniProtKB/TrEMBL
  ENSCAFG00000011555 Ensembl
  ENSCAFG00030003063 UniProtKB/TrEMBL
  ENSCAFG00040000695 UniProtKB/TrEMBL
  ENSCAFG00845003786 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000062830.2 UniProtKB/TrEMBL
  ENSCAFT00030005796.1 UniProtKB/TrEMBL
  ENSCAFT00040001342.1 UniProtKB/TrEMBL
  ENSCAFT00845006757.1 UniProtKB/TrEMBL
  ENSCAFT00845006768 ENTREZGENE
  ENSCAFT00845006768.1 UniProtKB/TrEMBL
Gene3D-CATH Galactose-binding domain-like UniProtKB/TrEMBL
  Laminin UniProtKB/TrEMBL
InterPro EGF-like_dom UniProtKB/TrEMBL
  FA58C UniProtKB/TrEMBL
  Galactose-bd-like_sf UniProtKB/TrEMBL
  Neuropilin_MCO_CoagFactor UniProtKB/TrEMBL
NCBI Gene MFGE8 ENTREZGENE
PANTHER EGF-LIKE REPEAT AND DISCOIDIN I-LIKE DOMAIN-CONTAINING PROTEIN 3 PRECURSOR UniProtKB/TrEMBL
  F5/8 TYPE C DOMAIN-CONTAINING PROTEIN UniProtKB/TrEMBL
Pfam EGF UniProtKB/TrEMBL
  F5_F8_type_C UniProtKB/TrEMBL
PROSITE EGF_1 UniProtKB/TrEMBL
  EGF_2 UniProtKB/TrEMBL
  EGF_3 UniProtKB/TrEMBL
  FA58C_1 UniProtKB/TrEMBL
  FA58C_2 UniProtKB/TrEMBL
  FA58C_3 UniProtKB/TrEMBL
SMART EGF UniProtKB/TrEMBL
  FA58C UniProtKB/TrEMBL
Superfamily-SCOP EGF/Laminin UniProtKB/TrEMBL
  SSF49785 UniProtKB/TrEMBL
UniProt A0A8C0L2C7 ENTREZGENE
  A0A8C0M951 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C0Q310 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3MJ48_CANLF UniProtKB/TrEMBL
  A0A8I3RT41 ENTREZGENE, UniProtKB/TrEMBL
  A0A8P0P7S2 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:53186 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-12-25 MFGE8  milk fat globule EGF and factor V/VIII domain containing  MFGE8  milk fat globule-EGF factor 8 protein  Symbol and/or name change 5135510 APPROVED