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Gene: Mfge8 (milk fat globule EGF and factor V/VIII domain containing) Rattus norvegicus
Symbol: Mfge8
Name: milk fat globule EGF and factor V/VIII domain containing
RGD ID: 3083
Description: Predicted to have integrin binding activity; phosphatidylethanolamine binding activity; and phosphatidylserine binding activity. Involved in positive regulation of cell population proliferation and response to estrogen. Predicted to localize to external side of plasma membrane; extracellular space; and extrinsic component of plasma membrane. Human ortholog(s) of this gene implicated in temporal arteritis. Orthologous to human MFGE8 (milk fat globule EGF and factor V/VIII domain containing); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,6-dinitrotoluene; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: AGS; lactadherin; MFG-E8; MFGM; MFGME8; MFGMP-E8; milk fat globule-EGF factor 8 protein; O-acetyl disialoganglioside synthase; O-acetyl GD3 ganglioside synthase; O-acetyltransferase milk fat globule membrane protein; O-acetyltransferase Milk fat glolbule membrane protein; OAcGD3S; SED1
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.01140,845,478 - 140,860,882 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1140,845,465 - 140,860,894 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01141,814,239 - 141,829,653 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41134,870,029 - 134,885,431 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11134,948,377 - 134,963,734 (-)NCBI
Celera1125,135,501 - 125,150,920 (-)NCBICelera
Cytogenetic Map1q31NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Mfge8
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 3083
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2020-09-29
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.