Slit3 (slit guidance ligand 3) - Rat Genome Database

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Gene: Slit3 (slit guidance ligand 3) Rattus norvegicus
Analyze
Symbol: Slit3
Name: slit guidance ligand 3
RGD ID: 69311
Description: Predicted to enable Roundabout binding activity and heparin binding activity. Involved in spinal cord development. Predicted to be located in extracellular space. Biomarker of congenital diaphragmatic hernia. Orthologous to human SLIT3 (slit guidance ligand 3); INTERACTS WITH 1-naphthyl isothiocyanate; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: Megf5; multiple EGF-like domains protein 5; multiple epidermal growth factor-like domains 5; multiple epidermal growth factor-like domains protein 5; slit (Drosophila) homolog 3; slit homolog 3 (Drosophila); slit homolog 3 protein; slit-3
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81020,075,929 - 20,660,704 (+)NCBIGRCr8
mRatBN7.21019,571,798 - 20,156,634 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1019,571,684 - 20,156,634 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1024,327,438 - 24,913,272 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01023,815,979 - 24,401,801 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01019,295,723 - 19,880,358 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01019,924,200 - 20,517,918 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1020,320,878 - 20,518,518 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01019,801,599 - 20,392,415 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41019,983,166 - 20,576,689 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11020,098,220 - 20,577,738 (+)NCBI
Celera1019,201,522 - 19,782,964 (+)NCBICelera
Cytogenetic Map10q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (EXP)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP)
2,4-dinitrotoluene  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
7,12-dimethyltetraphene  (ISO)
acetaldehyde  (ISO)
acetic acid [2-[[(5-nitro-2-thiazolyl)amino]-oxomethyl]phenyl] ester  (ISO)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
ammonium chloride  (EXP)
antirheumatic drug  (ISO)
aripiprazole  (EXP)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
atrazine  (EXP)
benzo[a]pyrene  (ISO)
benzo[e]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
CGP 52608  (ISO)
chlormequat chloride  (EXP)
chlorpyrifos  (EXP)
choline  (ISO)
cisplatin  (ISO)
clobetasol  (ISO)
daunorubicin  (ISO)
dexamethasone  (ISO)
diuron  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
ethanol  (ISO)
flusilazole  (ISO)
folic acid  (ISO)
fonofos  (ISO)
formaldehyde  (ISO)
fulvestrant  (ISO)
furan  (EXP)
genistein  (ISO)
gentamycin  (EXP)
glyphosate  (EXP)
indometacin  (ISO)
isotretinoin  (ISO)
L-methionine  (ISO)
mercury atom  (ISO)
mercury dibromide  (ISO)
mercury(0)  (ISO)
methapyrilene  (ISO)
methoxychlor  (EXP)
mifepristone  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
N,N-diethyl-m-toluamide  (EXP)
nickel atom  (ISO)
nitrofen  (EXP)
oxaliplatin  (EXP)
ozone  (ISO)
panobinostat  (ISO)
parathion  (ISO)
permethrin  (EXP)
phenylmercury acetate  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
potassium chromate  (ISO)
potassium dichromate  (ISO)
progesterone  (ISO)
propanal  (ISO)
SB 431542  (ISO)
sodium arsenite  (ISO)
Soman  (EXP)
sunitinib  (ISO)
temozolomide  (ISO)
terbufos  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
topotecan  (EXP)
trichostatin A  (ISO)
trimellitic anhydride  (ISO)
troglitazone  (ISO)
tunicamycin  (ISO)
valproic acid  (EXP,ISO)
vinclozolin  (EXP)
vorinostat  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Slit proteins bind Robo receptors and have an evolutionarily conserved role in repulsive axon guidance. Brose K, etal., Cell 1999 Mar 19;96(6):795-806.
2. Upregulation of Slit-2 and Slit-3 gene expressions in the nitrofen-induced hypoplastic lung. Doi T, etal., J Pediatr Surg. 2009 Nov;44(11):2092-5. doi: 10.1016/j.jpedsurg.2009.02.068.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. Dual trafficking of Slit3 to mitochondria and cell surface demonstrates novel localization for Slit protein. Little MH, etal., Am J Physiol Cell Physiol 2001 Aug;281(2):C486-95.
6. Spatiotemporal expression patterns of slit and robo genes in the rat brain. Marillat V, etal., J Comp Neurol. 2002 Jan 7;442(2):130-55.
7. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
8. Identification of high-molecular-weight proteins with multiple EGF-like motifs by motif-trap screening. Nakayama M, etal., Genomics 1998 Jul 1;51(1):27-34.
9. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
10. GOA pipeline RGD automated data pipeline
11. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
12. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
13. Comprehensive gene review and curation RGD comprehensive gene curation
14. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
15. Expression of netrin-1, slit-1 and slit-3 but not of slit-2 after cerebellar and spinal cord lesions. Wehrle R, etal., Eur J Neurosci. 2005 Nov;22(9):2134-44.
Additional References at PubMed
PMID:11748139   PMID:12954717   PMID:14550534   PMID:15091338   PMID:15207848   PMID:16840550   PMID:18566128   PMID:18755265   PMID:18829537   PMID:19741192   PMID:22206666   PMID:24006456  
PMID:25691540   PMID:28363469   PMID:35318077  


Genomics

Comparative Map Data
Slit3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81020,075,929 - 20,660,704 (+)NCBIGRCr8
mRatBN7.21019,571,798 - 20,156,634 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1019,571,684 - 20,156,634 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1024,327,438 - 24,913,272 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01023,815,979 - 24,401,801 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01019,295,723 - 19,880,358 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01019,924,200 - 20,517,918 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1020,320,878 - 20,518,518 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01019,801,599 - 20,392,415 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41019,983,166 - 20,576,689 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11020,098,220 - 20,577,738 (+)NCBI
Celera1019,201,522 - 19,782,964 (+)NCBICelera
Cytogenetic Map10q12NCBI
SLIT3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385168,661,740 - 169,301,139 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl5168,661,740 - 169,301,139 (-)EnsemblGRCh38hg38GRCh38
GRCh375168,088,745 - 168,728,143 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 365168,025,857 - 168,660,554 (-)NCBINCBI36Build 36hg18NCBI36
Build 345168,025,856 - 168,660,554NCBI
Celera5164,128,856 - 164,759,439 (-)NCBICelera
Cytogenetic Map5q34-q35.1NCBI
HuRef5163,187,021 - 163,825,867 (-)NCBIHuRef
CHM1_15167,521,662 - 168,160,538 (-)NCBICHM1_1
T2T-CHM13v2.05169,196,497 - 169,836,714 (-)NCBIT2T-CHM13v2.0
Slit3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391135,012,283 - 35,599,334 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1135,012,051 - 35,599,334 (+)EnsemblGRCm39 Ensembl
GRCm381135,121,456 - 35,708,507 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1135,121,224 - 35,708,507 (+)EnsemblGRCm38mm10GRCm38
MGSCv371134,934,958 - 35,522,009 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361134,964,879 - 35,551,735 (+)NCBIMGSCv36mm8
Celera1138,900,451 - 39,489,864 (+)NCBICelera
Cytogenetic Map11A4NCBI
cM Map1120.29NCBI
Slit3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540821,722,632 - 22,322,917 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540821,719,487 - 22,322,958 (-)NCBIChiLan1.0ChiLan1.0
SLIT3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v24163,822,402 - 164,461,801 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan15161,966,392 - 162,604,913 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v05164,029,432 - 164,664,156 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.15170,793,386 - 171,425,236 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5170,793,731 - 171,425,242 (-)Ensemblpanpan1.1panPan2
SLIT3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1442,506,680 - 43,099,053 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl442,508,426 - 43,094,714 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha442,466,027 - 43,055,860 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0442,928,562 - 43,521,077 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl442,928,887 - 43,516,993 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1442,700,926 - 43,290,974 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0442,893,778 - 43,485,410 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0443,399,255 - 43,991,187 (+)NCBIUU_Cfam_GSD_1.0
Slit3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721396,574,901 - 97,136,840 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936622565,346 - 752,299 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936622191,165 - 756,552 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SLIT3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1654,553,426 - 55,220,296 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11654,551,536 - 55,221,427 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21659,123,810 - 59,790,312 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SLIT3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12370,890,096 - 71,524,002 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2370,885,737 - 71,106,703 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660347,156,377 - 7,794,096 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Slit3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473320,683,814 - 21,291,088 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473320,683,680 - 21,293,663 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Slit3
3857 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:44
Count of miRNA genes:32
Interacting mature miRNAs:44
Transcripts:ENSRNOT00000009714
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
6893352Bw100Body weight QTL 1000.330.6body mass (VT:0001259)body weight (CMO:0000012)11590666560906665Rat
9589136Insul27Insulin level QTL 2710.460.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)101147401056474010Rat
631564Apr3Acute phase response QTL 33.9blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)101527595560275955Rat
8662860Vetf10Vascular elastic tissue fragility QTL 10artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)10615418273453136Rat
2313066Bss63Bone structure and strength QTL 631.40.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)10538701450387014Rat
631554Bp133Blood pressure QTL 1330.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1074336463851208Rat
2313064Bmd71Bone mineral density QTL 710.90.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)10538701450387014Rat
70223Bp57Blood pressure QTL 575arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)10180676123Rat
1354587Kidm21Kidney mass QTL 213.3kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)101502851360430477Rat
6893350Bw99Body weight QTL 990.870.16body mass (VT:0001259)body weight (CMO:0000012)11590666560906665Rat
634329Pia15Pristane induced arthritis QTL 153.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10124158324Rat
1578761Stresp21Stress response QTL 213.3thymus mass (VT:0004954)thymus wet weight (CMO:0000855)10637574651375746Rat
2293680Bss40Bone structure and strength QTL 405.660.0001femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)10135225947Rat
2298544Neuinf9Neuroinflammation QTL 94.6nervous system integrity trait (VT:0010566)spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)10580199062146030Rat
7387235Uae41Urinary albumin excretion QTL 415.260.1874urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)10129497586Rat
10401803Kidm50Kidney mass QTL 50kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1041834445418344Rat
1554317Bmd4Bone mineral density QTL 49.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)101981604299406971Rat
2313081Bss64Bone structure and strength QTL 641.30.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)10538701450387014Rat
1598852Anxrr19Anxiety related response QTL 195.07body movement coordination trait (VT:0005424)number of rearing movements in an experimental apparatus (CMO:0001752)101816784163167841Rat
2313087Bmd80Bone mineral density QTL 803.20.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)101960648364606483Rat
634327Hc4Hypercalciuria QTL 42.4urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)10138328221Rat
2313095Bss62Bone structure and strength QTL 621.50.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)10538701450387014Rat
631532Cm50Cardiac mass QTL 506.6heart mass (VT:0007028)calculated heart weight (CMO:0000073)101790711351786432Rat
1576304Schws7Schwannoma susceptibility QTL 70.0115nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)10476552719816042Rat
7411611Foco17Food consumption QTL 1718.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)10142315980Rat
2301967Cm73Cardiac mass QTL 734.55heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)101448701189062041Rat
2303118Mamtr7Mammary tumor resistance QTL 70.003mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)109658275104670812Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014487011104060283Rat
9590268Scort13Serum corticosterone level QTL 133.260.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)101147401056474010Rat
2313104Bss61Bone structure and strength QTL 610.90.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)10538701450387014Rat
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10635789696121100Rat
9590310Scort19Serum corticosterone level QTL 196.30.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)101147401056474010Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014487011107057807Rat
2313055Bw96Body weight QTL 963.60.0001body mass (VT:0001259)body weight (CMO:0000012)101960648364606483Rat

Markers in Region
D10Mit16  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21019,606,483 - 19,606,574 (+)MAPPERmRatBN7.2
Rnor_6.01019,958,696 - 19,958,786NCBIRnor6.0
Rnor_5.01019,835,926 - 19,836,016UniSTSRnor5.0
RGSC_v3.41020,018,844 - 20,018,935RGDRGSC3.4
RGSC_v3.41020,018,845 - 20,018,935UniSTSRGSC3.4
RGSC_v3.11020,019,893 - 20,019,984RGD
Celera1019,236,271 - 19,236,361UniSTS
SHRSP x BN Map1020.45UniSTS
SHRSP x BN Map1020.45RGD
FHH x ACI Map1014.0RGD
Cytogenetic Map10q12UniSTS
D10Rat45  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21019,815,919 - 19,816,042 (+)MAPPERmRatBN7.2
Rnor_6.01020,169,909 - 20,170,031NCBIRnor6.0
Rnor_5.01020,046,344 - 20,046,466UniSTSRnor5.0
RGSC_v3.41020,233,007 - 20,233,129UniSTSRGSC3.4
RGSC_v3.41020,233,004 - 20,233,281RGDRGSC3.4
RGSC_v3.11020,234,056 - 20,234,178RGD
Celera1019,443,769 - 19,443,891UniSTS
RH 3.4 Map10214.43RGD
RH 3.4 Map10214.43UniSTS
RH 2.0 Map10220.8RGD
SHRSP x BN Map1021.6RGD
FHH x ACI Map1014.0RGD
Cytogenetic Map10q12UniSTS
D10Rat113  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21019,570,513 - 19,570,752 (+)MAPPERmRatBN7.2
Rnor_6.01019,922,916 - 19,923,154NCBIRnor6.0
Rnor_5.01019,800,315 - 19,800,553UniSTSRnor5.0
RGSC_v3.41019,981,882 - 19,982,120UniSTSRGSC3.4
RGSC_v3.41019,981,830 - 19,982,189RGDRGSC3.4
RGSC_v3.11019,982,931 - 19,983,169RGD
Celera1019,200,238 - 19,200,476UniSTS
RH 3.4 Map10214.43RGD
RH 3.4 Map10214.43UniSTS
RH 2.0 Map10217.1RGD
SHRSP x BN Map1020.49RGD
FHH x ACI Map1014.03RGD
Cytogenetic Map10q12UniSTS
D11Mit186  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21019,685,116 - 19,685,266 (+)MAPPERmRatBN7.2
Rnor_6.01020,037,355 - 20,037,504NCBIRnor6.0
Rnor_5.01019,913,800 - 19,913,949UniSTSRnor5.0
RGSC_v3.41020,098,080 - 20,098,229UniSTSRGSC3.4
Celera1019,313,598 - 19,313,747UniSTS
Cytogenetic Map10q12UniSTS
RH143863  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21020,007,320 - 20,007,473 (+)MAPPERmRatBN7.2
Rnor_6.01020,367,558 - 20,367,710NCBIRnor6.0
Rnor_5.01020,242,006 - 20,242,158UniSTSRnor5.0
RGSC_v3.41020,426,280 - 20,426,432UniSTSRGSC3.4
Celera1019,633,830 - 19,633,982UniSTS
Cytogenetic Map10q12UniSTS
BF399581  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21019,858,250 - 19,858,445 (+)MAPPERmRatBN7.2
Rnor_6.01020,212,230 - 20,212,424NCBIRnor6.0
Rnor_5.01020,089,093 - 20,089,287UniSTSRnor5.0
RGSC_v3.41020,276,570 - 20,276,764UniSTSRGSC3.4
Celera1019,486,121 - 19,486,315UniSTS
Cytogenetic Map10q12UniSTS
BF405181  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21019,779,588 - 19,779,797 (+)MAPPERmRatBN7.2
Rnor_6.01020,131,797 - 20,132,005NCBIRnor6.0
Rnor_5.01020,008,232 - 20,008,440UniSTSRnor5.0
RGSC_v3.41020,194,057 - 20,194,265UniSTSRGSC3.4
Celera1019,407,950 - 19,408,158UniSTS
Cytogenetic Map10q12UniSTS
BE108987  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21019,904,217 - 19,904,416 (+)MAPPERmRatBN7.2
Rnor_6.01020,258,085 - 20,258,283NCBIRnor6.0
Rnor_5.01020,134,869 - 20,135,067UniSTSRnor5.0
RGSC_v3.41020,322,623 - 20,322,821UniSTSRGSC3.4
Celera1019,531,834 - 19,532,032UniSTS
Cytogenetic Map10q12UniSTS
RH138151  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21019,720,770 - 19,720,999 (+)MAPPERmRatBN7.2
Rnor_6.01020,073,026 - 20,073,254NCBIRnor6.0
Rnor_5.01019,949,481 - 19,949,709UniSTSRnor5.0
RGSC_v3.41020,134,211 - 20,134,439UniSTSRGSC3.4
Celera1019,349,245 - 19,349,473UniSTS
Cytogenetic Map10q12UniSTS
BG373360  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21020,070,297 - 20,070,508 (+)MAPPERmRatBN7.2
Rnor_6.01020,430,508 - 20,430,718NCBIRnor6.0
Rnor_5.01020,305,005 - 20,305,215UniSTSRnor5.0
RGSC_v3.41020,489,279 - 20,489,489UniSTSRGSC3.4
Celera1019,696,795 - 19,697,005UniSTS
RH 3.4 Map10215.32UniSTS
Cytogenetic Map10q12UniSTS
AU048637  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21019,606,415 - 19,606,644 (+)MAPPERmRatBN7.2
Rnor_6.01019,958,628 - 19,958,856NCBIRnor6.0
Rnor_5.01019,835,858 - 19,836,086UniSTSRnor5.0
RGSC_v3.41020,018,777 - 20,019,005UniSTSRGSC3.4
Celera1019,236,203 - 19,236,431UniSTS
Cytogenetic Map10q12UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000009714   ⟹   ENSRNOP00000009714
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1019,571,684 - 20,156,634 (+)Ensembl
Rnor_6.0 Ensembl1020,320,878 - 20,518,518 (+)Ensembl
RefSeq Acc Id: NM_031321   ⟹   NP_112611
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81020,075,929 - 20,660,704 (+)NCBI
mRatBN7.21019,571,798 - 20,156,634 (+)NCBI
Rnor_6.01019,924,200 - 20,517,918 (+)NCBI
Rnor_5.01019,801,599 - 20,392,415 (+)NCBI
RGSC_v3.41019,983,166 - 20,576,689 (+)RGD
Celera1019,201,522 - 19,782,964 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_112611 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein BAA32461 (Get FASTA)   NCBI Sequence Viewer  
  EDM04090 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000009714.7
GenBank Protein O88280 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_112611   ⟸   NM_031321
- Peptide Label: precursor
- UniProtKB: O88280 (UniProtKB/Swiss-Prot),   F1LQL9 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000009714   ⟸   ENSRNOT00000009714
Protein Domains
CTCK   EGF-like   Laminin G   Laminin G-like   LRRCT   LRRNT

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O88280-F1-model_v2 AlphaFold O88280 1-1523 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:69311 AgrOrtholog
BioCyc Gene G2FUF-25558 BioCyc
Ensembl Genes ENSRNOG00000007377 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000009714.6 UniProtKB/TrEMBL
Gene3D-CATH 2.60.120.200 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.80.10.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Laminin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro ConA-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cys-rich_flank_reg_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cys_knot_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF-like_Ca-bd_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF-like_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF-type_Asp/Asn_hydroxyl_site UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_Ca-bd_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Growth_fac_rcpt_cys_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Laminin_G UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Leu-rich_rpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Leu-rich_rpt_typical-subtyp UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LRR_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LRRNT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Notch/Slit_guidance UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:83467 UniProtKB/Swiss-Prot
NCBI Gene 83467 ENTREZGENE
PANTHER PROTEIN SLIT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SLIT HOMOLOG UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SLIT HOMOLOG 3 PROTEIN UniProtKB/TrEMBL
Pfam EGF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Laminin_G_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LRR_8 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LRRCT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LRRNT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Slit3 PhenoGen
PROSITE ASX_HYDROXYL UniProtKB/TrEMBL
  CTCK_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CTCK_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_CA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LAM_G_DOMAIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LRR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000007377 RatGTEx
SMART EGF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_CA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LamG UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LRR_BAC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LRR_RI UniProtKB/TrEMBL
  LRR_SD22 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LRR_TYP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LRRCT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LRRNT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SM00041 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP EGF/Laminin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  L domain-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF49899 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF57184 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC207770
UniProt A6HDI5_RAT UniProtKB/TrEMBL
  F1LQL9 ENTREZGENE, UniProtKB/TrEMBL
  O88280 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-07-01 Slit3  slit guidance ligand 3  Slit3  slit homolog 3 (Drosophila)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Slit3  slit homolog 3 (Drosophila)      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference