ZFP36L1 (ZFP36 ring finger protein like 1) - Rat Genome Database

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Gene: ZFP36L1 (ZFP36 ring finger protein like 1) Homo sapiens
Analyze
Symbol: ZFP36L1
Name: ZFP36 ring finger protein like 1
RGD ID: 732154
HGNC Page HGNC
Description: Enables 14-3-3 protein binding activity and mRNA 3'-UTR AU-rich region binding activity. Involved in several processes, including cellular response to hormone stimulus; regulation of mRNA metabolic process; and regulation of myeloid cell differentiation. Acts upstream of or within regulation of mRNA stability. Located in P-body and nucleus. Part of ribonucleoprotein complex.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: Berg36; BRF1; butyrate response factor 1; cMG1; early response factor Berg36; EGF-response factor 1; ERF-1; ERF1; mRNA decay activator protein ZFP36L1; RNF162B; TIS11B; TPA-induced sequence 11b; ZFP36 ring finger protein-like 1; ZFP36-like 1; zinc finger protein 36, C3H type-like 1; zinc finger protein 36, C3H1 type-like 1; zinc finger protein, C3H type, 36-like 1
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1468,787,660 - 68,796,253 (-)EnsemblGRCh38hg38GRCh38
GRCh381468,787,655 - 68,796,243 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371469,254,372 - 69,262,960 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361468,324,128 - 68,329,538 (-)NCBINCBI36hg18NCBI36
Build 341468,324,127 - 68,329,538NCBI
Celera1449,313,123 - 49,318,532 (-)NCBI
Cytogenetic Map14q24.1NCBI
HuRef1449,422,410 - 49,430,997 (-)NCBIHuRef
CHM1_11469,192,821 - 69,201,405 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
COVID-19  (HEP)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(S)-colchicine  (EXP)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1-chloro-2,4-dinitrobenzene  (EXP)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2-butoxyethanol  (ISO)
2-hydroxypropanoic acid  (EXP)
3,3',4,4'-tetrachlorobiphenyl  (EXP)
3-chloropropane-1,2-diol  (ISO)
3H-1,2-dithiole-3-thione  (ISO)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (EXP)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (EXP)
6-propyl-2-thiouracil  (ISO)
8-Br-cAMP  (EXP)
adenine  (EXP)
aflatoxin B1  (EXP,ISO)
all-trans-retinoic acid  (EXP)
aristolochic acid  (EXP,ISO)
Aroclor 1254  (EXP)
arsenous acid  (EXP)
benzo[a]pyrene  (EXP,ISO)
bisphenol A  (EXP,ISO)
buta-1,3-diene  (ISO)
C.I. Natural Red 20  (ISO)
cadmium dichloride  (EXP,ISO)
carboplatin  (ISO)
chloropicrin  (EXP)
choline  (ISO)
cisplatin  (EXP)
cobalt dichloride  (EXP)
colforsin daropate hydrochloride  (ISO)
copper(II) sulfate  (EXP)
CU-O LINKAGE  (EXP)
Cuprizon  (ISO)
curcumin  (EXP)
cyclophosphamide  (ISO)
cyclosporin A  (EXP)
depsipeptide  (EXP)
dexamethasone  (EXP,ISO)
diarsenic trioxide  (EXP)
dibutyl phthalate  (ISO)
dicrotophos  (EXP)
dieldrin  (EXP)
diethylstilbestrol  (ISO)
doxorubicin  (EXP)
ethanol  (ISO)
ethyl methanesulfonate  (EXP)
etoposide  (EXP)
fluoranthene  (ISO)
flutamide  (ISO)
folic acid  (ISO)
formaldehyde  (EXP)
genistein  (EXP)
gentamycin  (ISO)
ivermectin  (EXP)
L-methionine  (ISO)
leflunomide  (EXP)
lipopolysaccharide  (ISO)
medroxyprogesterone acetate  (EXP)
menadione  (EXP)
methamphetamine  (ISO)
methyl methanesulfonate  (EXP)
methylmercury chloride  (EXP)
mitomycin C  (EXP)
N,N-diethyl-m-toluamide  (ISO)
N-nitrosodiethylamine  (ISO)
nefazodone  (ISO)
nickel subsulfide  (EXP)
nickel sulfate  (EXP)
nimesulide  (ISO)
oxaliplatin  (ISO)
p-menthan-3-ol  (EXP)
paracetamol  (EXP,ISO)
pentachlorophenol  (ISO)
permethrin  (ISO)
phenobarbital  (EXP,ISO)
pirinixic acid  (ISO)
progesterone  (EXP)
promegestone  (EXP)
quercetin  (EXP)
rac-lactic acid  (EXP)
Shikonin  (ISO)
sodium arsenite  (EXP)
sodium dichromate  (EXP)
Soman  (ISO)
succimer  (EXP)
tamoxifen  (ISO)
temozolomide  (EXP)
tetrachloromethane  (ISO)
tetraphene  (ISO)
topotecan  (ISO)
tungsten  (ISO)
valproic acid  (EXP)
vinclozolin  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
3'-UTR-mediated mRNA destabilization  (IDA,IMP)
apoptotic process  (IEA,ISO)
cell population proliferation  (IEA,ISO)
cellular response to cAMP  (IDA)
cellular response to epidermal growth factor stimulus  (IDA)
cellular response to fibroblast growth factor stimulus  (ISS)
cellular response to glucocorticoid stimulus  (IDA)
cellular response to hypoxia  (IMP)
cellular response to insulin stimulus  (IDA)
cellular response to peptide hormone stimulus  (IDA)
cellular response to raffinose  (ISS)
cellular response to salt stress  (ISS)
cellular response to transforming growth factor beta stimulus  (IDA)
cellular response to tumor necrosis factor  (IDA)
chorio-allantoic fusion  (IEA,ISO)
embryonic organ development  (ISO)
ERK1 and ERK2 cascade  (IDA)
heart development  (IEA,ISO)
MAPK cascade  (IDA)
mesendoderm development  (ISS)
mRNA catabolic process  (ISO)
mRNA processing  (IEA)
mRNA transport  (IMP)
multicellular organism growth  (IEA,ISO)
negative regulation of erythrocyte differentiation  (IDA)
negative regulation of mitotic cell cycle phase transition  (ISS)
neural tube development  (IEA,ISO)
nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay  (IEA,ISO)
nuclear-transcribed mRNA catabolic process, deadenylation-independent decay  (ISS)
p38MAPK cascade  (ISS)
phosphatidylinositol 3-kinase signaling  (IDA)
positive regulation of fat cell differentiation  (ISS)
positive regulation of intracellular mRNA localization  (IMP)
positive regulation of monocyte differentiation  (IDA)
positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay  (ISS)
proepicardium development  (IEA,ISO)
protein kinase B signaling  (ISS)
regulation of B cell differentiation  (ISS)
regulation of gene expression  (IDA)
regulation of keratinocyte apoptotic process  (IMP)
regulation of keratinocyte differentiation  (IMP)
regulation of keratinocyte proliferation  (IMP)
regulation of mRNA 3'-end processing  (IDA)
regulation of mRNA stability  (IDA,IMP)
regulation of myoblast differentiation  (ISS)
regulation of stem cell proliferation  (ISS)
regulation of translation  (ISO)
response to wounding  (IDA)
spongiotrophoblast layer development  (IEA,ISO)
T cell differentiation in thymus  (ISS)
vasculogenesis  (IEA,ISO)

Cellular Component
cytoplasm  (IDA,IEA)
cytosol  (TAS)
nucleus  (IDA)
P-body  (IDA)
ribonucleoprotein complex  (IDA)

Molecular Function

References

Additional References at PubMed
PMID:8024689   PMID:8346037   PMID:8595910   PMID:8889548   PMID:8898945   PMID:12198173   PMID:12477932   PMID:14604009   PMID:14702039   PMID:15146197   PMID:15342556   PMID:15465005  
PMID:15467755   PMID:15489334   PMID:15538381   PMID:15687258   PMID:16169070   PMID:16189514   PMID:16344560   PMID:17030608   PMID:17369404   PMID:18326031   PMID:18418350   PMID:19092855  
PMID:19179481   PMID:19274049   PMID:19322201   PMID:19417104   PMID:19417105   PMID:19430480   PMID:19801654   PMID:20166898   PMID:20190752   PMID:20702587   PMID:20967262   PMID:21044950  
PMID:21102463   PMID:21278925   PMID:21832157   PMID:21833088   PMID:21873635   PMID:22658674   PMID:23128233   PMID:23535732   PMID:24086717   PMID:24700863   PMID:25014217   PMID:25106868  
PMID:25670004   PMID:26542173   PMID:26673895   PMID:26972000   PMID:27182009   PMID:29426877   PMID:30622281   PMID:30655376   PMID:31551365   PMID:31999936   PMID:32311426   PMID:32509391  
PMID:32556261   PMID:32687160  


Genomics

Comparative Map Data
ZFP36L1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1468,787,660 - 68,796,253 (-)EnsemblGRCh38hg38GRCh38
GRCh381468,787,655 - 68,796,243 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371469,254,372 - 69,262,960 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361468,324,128 - 68,329,538 (-)NCBINCBI36hg18NCBI36
Build 341468,324,127 - 68,329,538NCBI
Celera1449,313,123 - 49,318,532 (-)NCBI
Cytogenetic Map14q24.1NCBI
HuRef1449,422,410 - 49,430,997 (-)NCBIHuRef
CHM1_11469,192,821 - 69,201,405 (-)NCBICHM1_1
Zfp36l1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391280,154,534 - 80,159,787 (-)NCBIGRCm39mm39
GRCm39 Ensembl1280,154,528 - 80,159,787 (-)Ensembl
GRCm381280,107,760 - 80,113,013 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1280,107,754 - 80,113,013 (-)EnsemblGRCm38mm10GRCm38
MGSCv371281,208,747 - 81,214,000 (-)NCBIGRCm37mm9NCBIm37
MGSCv361281,026,600 - 81,031,853 (-)NCBImm8
Celera1281,572,651 - 81,577,898 (-)NCBICelera
Cytogenetic Map12C3NCBI
Zfp36l1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2698,930,705 - 98,935,748 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl698,930,718 - 98,935,748 (-)Ensembl
Rnor_6.06103,308,032 - 103,313,074 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6103,308,045 - 103,313,074 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.06115,987,360 - 115,992,381 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.46103,119,555 - 103,124,576 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.16103,123,010 - 103,128,032 (-)NCBI
Celera697,294,425 - 97,299,423 (-)NCBICelera
Cytogenetic Map6q24NCBI
Zfp36l1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554661,541,323 - 1,546,617 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554661,541,367 - 1,546,617 (+)NCBIChiLan1.0ChiLan1.0
ZFP36L1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11468,247,341 - 68,255,805 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1468,247,347 - 68,255,805 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01449,372,058 - 49,379,116 (-)NCBIMhudiblu_PPA_v0panPan3
ZFP36L1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1842,663,287 - 42,668,665 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl842,664,223 - 42,668,514 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha842,352,777 - 42,358,311 (-)NCBI
ROS_Cfam_1.0842,893,323 - 42,898,832 (-)NCBI
UMICH_Zoey_3.1842,507,658 - 42,513,193 (-)NCBI
UNSW_CanFamBas_1.0842,582,437 - 42,587,961 (-)NCBI
UU_Cfam_GSD_1.0842,941,809 - 42,947,345 (-)NCBI
Zfp36l1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864062,140,623 - 62,145,363 (+)NCBI
SpeTri2.0NW_00493649512,045,679 - 12,050,737 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ZFP36L1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl792,490,011 - 92,495,574 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1792,490,069 - 92,495,864 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2798,803,589 - 98,809,023 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ZFP36L1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12446,000,222 - 46,005,455 (-)NCBI
ChlSab1.1 Ensembl2445,999,623 - 46,006,218 (-)Ensembl
Vero_WHO_p1.0NW_02366605334,233,922 - 34,240,910 (-)NCBI
Zfp36l1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462473432,251,100 - 32,256,458 (+)NCBI

Position Markers
SHGC-12024  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371469,255,993 - 69,256,107UniSTSGRCh37
Build 361468,325,746 - 68,325,860RGDNCBI36
Celera1449,314,740 - 49,314,854RGD
Cytogenetic Map14q22-q24UniSTS
HuRef1449,424,030 - 49,424,144UniSTS
TNG Radiation Hybrid Map1424003.0UniSTS
GeneMap99-G3 RH Map142548.0UniSTS
RH68093  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371469,261,559 - 69,261,643UniSTSGRCh37
Build 361468,331,312 - 68,331,396RGDNCBI36
Celera1449,320,306 - 49,320,390RGD
Cytogenetic Map14q22-q24UniSTS
HuRef1449,429,596 - 49,429,680UniSTS
GeneMap99-GB4 RH Map14171.55UniSTS
RH70919  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371469,254,142 - 69,254,343UniSTSGRCh37
Build 361468,323,895 - 68,324,096RGDNCBI36
Celera1449,312,890 - 49,313,091RGD
Cytogenetic Map14q22-q24UniSTS
HuRef1449,422,180 - 49,422,381UniSTS
GeneMap99-GB4 RH Map14172.21UniSTS
RH70918  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371469,259,390 - 69,259,631UniSTSGRCh37
Build 361468,329,143 - 68,329,384RGDNCBI36
Celera1449,318,137 - 49,318,378RGD
Cytogenetic Map14q22-q24UniSTS
HuRef1449,427,427 - 49,427,668UniSTS
PMC126184P2  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371469,256,247 - 69,256,742UniSTSGRCh37
Build 361468,326,000 - 68,326,495RGDNCBI36
Celera1449,314,994 - 49,315,489RGD
Cytogenetic Map14q22-q24UniSTS
HuRef1449,424,284 - 49,424,779UniSTS
SHGC-64127  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371469,261,505 - 69,261,640UniSTSGRCh37
Build 361468,331,258 - 68,331,393RGDNCBI36
Celera1449,320,252 - 49,320,387RGD
Cytogenetic Map14q22-q24UniSTS
HuRef1449,429,542 - 49,429,677UniSTS
TNG Radiation Hybrid Map1424010.0UniSTS
G15966  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371469,254,378 - 69,254,585UniSTSGRCh37
Build 361468,324,131 - 68,324,338RGDNCBI36
Celera1449,313,126 - 49,313,333RGD
Cytogenetic Map14q22-q24UniSTS
HuRef1449,422,416 - 49,422,623UniSTS

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:4253
Count of miRNA genes:1133
Interacting mature miRNAs:1406
Transcripts:ENST00000336440, ENST00000408913, ENST00000439696, ENST00000553375, ENST00000555997, ENST00000557022, ENST00000557086
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component pharyngeal arch
High 4 23 1 7 84 63 1 11 41
Medium 2428 2945 1722 622 1905 464 4271 2177 3558 415 1383 1562 171 1193 2747 4
Low 5 17 1 1 35 1 16 147 3 9 36 1
Below cutoff 2 3 1 4 2 21 1 5 13 4 1 1

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001244698 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001244701 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_004926 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AI493871 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AI809725 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK024202 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK294363 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK303917 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL132986 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC018340 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BM712842 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BP353132 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BQ004874 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BQ894292 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BT019468 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471061 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CN312799 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DA633985 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DA876968 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DB522201 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DR423896 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FY210721 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KT583919 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X79066 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X79067 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X99404 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000336440   ⟹   ENSP00000337386
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1468,788,605 - 68,794,736 (-)Ensembl
RefSeq Acc Id: ENST00000439696   ⟹   ENSP00000388402
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1468,787,662 - 68,793,067 (-)Ensembl
RefSeq Acc Id: ENST00000553375   ⟹   ENSP00000452119
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1468,790,189 - 68,796,214 (-)Ensembl
RefSeq Acc Id: ENST00000555997   ⟹   ENSP00000451093
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1468,787,660 - 68,791,243 (-)Ensembl
RefSeq Acc Id: ENST00000557022   ⟹   ENSP00000450600
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1468,789,955 - 68,796,081 (-)Ensembl
RefSeq Acc Id: ENST00000557086   ⟹   ENSP00000450784
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1468,789,945 - 68,796,253 (-)Ensembl
RefSeq Acc Id: NM_001244698   ⟹   NP_001231627
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381468,787,662 - 68,793,416 (-)NCBI
GRCh371469,254,372 - 69,263,184 (-)NCBI
HuRef1449,422,410 - 49,430,997 (-)NCBI
CHM1_11469,192,821 - 69,199,076 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001244701   ⟹   NP_001231630
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381468,787,655 - 68,796,243 (-)NCBI
HuRef1449,422,410 - 49,430,997 (-)NCBI
CHM1_11469,192,821 - 69,201,405 (-)NCBI
Sequence:
RefSeq Acc Id: NM_004926   ⟹   NP_004917
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381468,787,662 - 68,793,067 (-)NCBI
GRCh371469,254,372 - 69,263,184 (-)NCBI
Build 361468,324,128 - 68,329,538 (-)NCBI Archive
HuRef1449,422,410 - 49,430,997 (-)NCBI
CHM1_11469,192,821 - 69,199,076 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_004917   ⟸   NM_004926
- Peptide Label: isoform 1
- UniProtKB: Q07352 (UniProtKB/Swiss-Prot),   A0A024R658 (UniProtKB/TrEMBL),   B3KNA8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001231630   ⟸   NM_001244701
- Peptide Label: isoform 2
- UniProtKB: Q07352 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001231627   ⟸   NM_001244698
- Peptide Label: isoform 1
- UniProtKB: Q07352 (UniProtKB/Swiss-Prot),   A0A024R658 (UniProtKB/TrEMBL),   B3KNA8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSP00000451093   ⟸   ENST00000555997
RefSeq Acc Id: ENSP00000388402   ⟸   ENST00000439696
RefSeq Acc Id: ENSP00000450600   ⟸   ENST00000557022
RefSeq Acc Id: ENSP00000450784   ⟸   ENST00000557086
RefSeq Acc Id: ENSP00000337386   ⟸   ENST00000336440
RefSeq Acc Id: ENSP00000452119   ⟸   ENST00000553375
Protein Domains
C3H1-type   Tis11B_N

Promoters
RGD ID:6810709
Promoter ID:HG_ACW:23418
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   CD4+TCell_2Hour,   HeLa_S3,   K562,   Lymphoblastoid
Transcripts:ZFP36L1.CAPR07-UNSPLICED,   ZFP36L1.HAPR07
Position:
Human AssemblyChrPosition (strand)Source
Build 361468,323,931 - 68,328,907 (-)MPROMDB
RGD ID:6792052
Promoter ID:HG_KWN:19650
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   CD4+TCell_2Hour,   HeLa_S3,   Jurkat,   K562,   Lymphoblastoid,   NB4
Transcripts:NM_004926,   UC001XKI.1
Position:
Human AssemblyChrPosition (strand)Source
Build 361468,329,356 - 68,330,317 (-)MPROMDB
RGD ID:6850624
Promoter ID:EP73106
Type:single initiation site
Name:HS_ZFP36L1
Description:Zinc finger protein 36, C3H type-like 1.
SO ACC ID:SO:0000170
Source:EPD (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:NEDO full length human cDNA sequencing project.; Oligo-capping
Position:
Human AssemblyChrPosition (strand)Source
Build 361468,329,534 - 68,329,594EPD
RGD ID:7227977
Promoter ID:EPDNEW_H19734
Type:initiation region
Name:ZFP36L1_1
Description:ZFP36 ring finger protein like 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H19735  EPDNEW_H19736  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381468,793,064 - 68,793,124EPDNEW
RGD ID:7227979
Promoter ID:EPDNEW_H19735
Type:initiation region
Name:ZFP36L1_3
Description:ZFP36 ring finger protein like 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H19734  EPDNEW_H19736  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381468,793,278 - 68,793,338EPDNEW
RGD ID:7227981
Promoter ID:EPDNEW_H19736
Type:initiation region
Name:ZFP36L1_2
Description:ZFP36 ring finger protein like 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H19734  EPDNEW_H19735  
Experiment Methods:Single-end sequencing.; Paired-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381468,796,249 - 68,796,309EPDNEW

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 14q24.1(chr14:67876421-69247382)x1 copy number loss See cases [RCV000051547] Chr14:67876421..69247382 [GRCh38]
Chr14:68343138..69714099 [GRCh37]
Chr14:67412891..68783852 [NCBI36]
Chr14:14q24.1
likely pathogenic
GRCh38/hg38 14q11.2-32.33(chr14:20151149-106855263)x3 copy number gain See cases [RCV000135543] Chr14:20151149..106855263 [GRCh38]
Chr14:20619308..107263478 [GRCh37]
Chr14:19689148..106334523 [NCBI36]
Chr14:14q11.2-32.33
pathogenic
GRCh38/hg38 14q11.2-32.33(chr14:20043514-106877229)x3 copy number gain See cases [RCV000143373] Chr14:20043514..106877229 [GRCh38]
Chr14:20511673..107285437 [GRCh37]
Chr14:19581513..106356482 [NCBI36]
Chr14:14q11.2-32.33
pathogenic
GRCh37/hg19 14q11.2-32.33(chr14:19794561-107234280)x3 copy number gain See cases [RCV000446256] Chr14:19794561..107234280 [GRCh37]
Chr14:14q11.2-32.33
pathogenic
GRCh37/hg19 14q23.2-32.33(chr14:62493932-107285437)x3 copy number gain See cases [RCV000448557] Chr14:62493932..107285437 [GRCh37]
Chr14:14q23.2-32.33
pathogenic
GRCh37/hg19 14q11.2-32.33(chr14:20511673-107285437) copy number gain See cases [RCV000512041] Chr14:20511673..107285437 [GRCh37]
Chr14:14q11.2-32.33
pathogenic
GRCh38/hg38 14q24.1(chr14:67823656-68813174)x1 copy number loss Poly (ADP-Ribose) polymerase inhibitor response [RCV000626430] Chr14:67823656..68813174 [GRCh38]
Chr14:68290373..69279891 [GRCh37]
Chr14:14q24.1
drug response
GRCh37/hg19 14q24.1-24.2(chr14:68035240-73568130)x1 copy number loss See cases [RCV000512344] Chr14:68035240..73568130 [GRCh37]
Chr14:14q24.1-24.2
likely pathogenic
GRCh37/hg19 14q11.1-32.33(chr14:19000422-107289053)x3 copy number gain not provided [RCV000738412] Chr14:19000422..107289053 [GRCh37]
Chr14:14q11.1-32.33
pathogenic
GRCh37/hg19 14q11.2-32.33(chr14:19280733-107287663)x3 copy number gain not provided [RCV000738413] Chr14:19280733..107287663 [GRCh37]
Chr14:14q11.2-32.33
pathogenic
GRCh37/hg19 14q11.2-32.33(chr14:19327823-107287663)x3 copy number gain not provided [RCV000738414] Chr14:19327823..107287663 [GRCh37]
Chr14:14q11.2-32.33
pathogenic
GRCh37/hg19 14q22.2-24.3(chr14:54654001-75828024)x3 copy number gain 14q22.2q24.3 duplication [RCV001506967] Chr14:54654001..75828024 [GRCh37]
Chr14:14q22.2-24.3
likely pathogenic

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:1107 AgrOrtholog
COSMIC ZFP36L1 COSMIC
Ensembl Genes ENSG00000185650 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSP00000337386 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000388402 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000450600 UniProtKB/TrEMBL
  ENSP00000450784 UniProtKB/TrEMBL
  ENSP00000451093 UniProtKB/TrEMBL
  ENSP00000452119 UniProtKB/TrEMBL
Ensembl Transcript ENST00000336440 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000439696 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000553375 UniProtKB/TrEMBL
  ENST00000555997 UniProtKB/TrEMBL
  ENST00000557022 UniProtKB/TrEMBL
  ENST00000557086 UniProtKB/TrEMBL
GTEx ENSG00000185650 GTEx
HGNC ID HGNC:1107 ENTREZGENE
Human Proteome Map ZFP36L1 Human Proteome Map
InterPro Tis11B_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_CCCH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_CCCH_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:677 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 677 ENTREZGENE
OMIM 601064 OMIM
Pfam Tis11B_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  zf-CCCH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA35027 PharmGKB
PROSITE ZF_C3H1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART ZnF_C3H1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF90229 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A024R658 ENTREZGENE, UniProtKB/TrEMBL
  B3KNA8 ENTREZGENE, UniProtKB/TrEMBL
  G3V2D5_HUMAN UniProtKB/TrEMBL
  G3V2P5_HUMAN UniProtKB/TrEMBL
  G3V382_HUMAN UniProtKB/TrEMBL
  G3V515_HUMAN UniProtKB/TrEMBL
  Q07352 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary Q13851 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-07-05 ZFP36L1  ZFP36 ring finger protein like 1    ZFP36 ring finger protein-like 1  Symbol and/or name change 5135510 APPROVED
2012-12-04 ZFP36L1  ZFP36 ring finger protein-like 1    zinc finger protein 36, C3H type-like 1  Symbol and/or name change 5135510 APPROVED