Tdgf1 (teratocarcinoma-derived growth factor 1)

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Gene: Tdgf1 (teratocarcinoma-derived growth factor 1) Mus musculus

Analyze

Symbol:

Tdgf1

Name:

teratocarcinoma-derived growth factor 1

RGD ID:

1617601

MGI Page

MGI

Description:

Exhibits several functions, including Wnt-protein binding activity; nodal binding activity; and type I activin receptor binding activity. Involved in several processes, including circulatory system development; negative regulation of transforming growth factor beta receptor signaling pathway; and nodal signaling pathway. Localizes to several cellular components, including Golgi apparatus; extrinsic component of plasma membrane; and perinuclear region of cytoplasm. Is expressed in several structures, including blastocyst; brain; embryo mesoderm; extraembryonic component; and heart. Human ortholog(s) of this gene implicated in colon cancer and congenital heart disease. Orthologous to several human genes including TDGF1 (teratocarcinoma-derived growth factor 1); PARTICIPATES IN glypican signaling pathway; INTERACTS WITH 2,2',4,4',5,5'-hexachlorobiphenyl; 2,2',5,5'-tetrachlorobiphenyl; 5-fluorouracil.

Type:

protein-coding

RefSeq Status:

VALIDATED

Also known as:

cr; CR1; cripto; cripto growth factor; epidermal growth factor-like Cripto protein; teratocarcinoma-derived growth factor; TERATOCARCINOMA-DERIVED GROWTH FACTOR PRECURSOR (EPIDERMAL GROWTH FACTOR-LIKE CRIPTO PROTEIN) (CRIPTO GROWTH FACTOR)

RGD Orthologs

Human

Rat

Chinchilla

Bonobo

Dog

Squirrel

Pig

Green Monkey

Naked Mole-Rat

Alliance Genes

More Info

more info ...

Related Pseudogenes:

Tdgf1-ps1 Tdgf1-ps2

Latest Assembly:

GRCm38 - Mouse Genome Assembly GRCm38

Position:

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	9	110,768,676 - 110,775,226 (-)	NCBI	GRCm39		mm39
GRCm38	9	110,939,608 - 110,946,158 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	9	110,939,603 - 110,946,158 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	9	110,842,112 - 110,848,662 (-)	NCBI	GRCm37		mm9	NCBIm37
MGSCv36	9	110,784,418 - 110,790,883 (-)	NCBI			mm8
Celera	9	110,664,719 - 110,671,594 (-)	NCBI		Celera
Cytogenetic Map	9	F2	NCBI
cM Map	9	60.79	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

colon cancer (ISO)

congenital heart disease (ISO)

Forebrain Defects (ISO)

holoprosencephaly (ISO)

Parkinson's disease (IDA)

teratoma (IDA)

visceral heterotaxy (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

2,2',4,4',5,5'-hexachlorobiphenyl (EXP)

2,2',5,5'-tetrachlorobiphenyl (EXP)

5-fluorouracil (EXP,ISO)

acetaldehyde (EXP)

acetic acid (EXP)

aflatoxin B1 (ISO)

all-trans-retinoic acid (EXP,ISO)

belinostat (ISO)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP)

bisphenol F (EXP)

bortezomib (ISO)

bromochloroacetic acid (EXP)

calciol (EXP)

carbon nanotube (EXP)

chlordecone (EXP)

copper(II) sulfate (ISO)

entinostat (ISO)

ethanol (ISO)

flusilazole (EXP)

folic acid (ISO)

hexaconazole (EXP)

leflunomide (ISO)

methylmercury chloride (EXP)

panobinostat (ISO)

paracetamol (ISO)

PCB138 (EXP)

sodium arsenite (ISO)

sunitinib (ISO)

testosterone (EXP)

thalidomide (EXP)

triadimefon (EXP)

trichostatin A (ISO)

triclosan (ISO)

urethane (ISO)

valproic acid (EXP,ISO)

vorinostat (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

activation of MAPK activity (ISO)

anatomical structure development (IBA)

anterior/posterior axis specification (IGI)

anterior/posterior axis specification, embryo (IMP)

anterior/posterior pattern specification (IBA)

blood vessel development (IBA)

cardiac muscle cell differentiation (IMP)

cell differentiation (TAS)

cell migration involved in sprouting angiogenesis (ISO)

cellular response to epidermal growth factor stimulus (ISO)

cellular response to fibroblast growth factor stimulus (ISO)

cellular response to hepatocyte growth factor stimulus (ISO)

cellular response to interferon-gamma (ISO)

cellular response to interleukin-6 (ISO)

cellular response to tumor necrosis factor (ISO)

determination of left/right symmetry (IBA)

epidermal growth factor receptor signaling pathway (ISO)

gastrulation (IGI)

heart development (IBA,IDA,ISO)

in utero embryonic development (IMP)

morphogenesis of a branching structure (IDA)

negative regulation of apoptotic process (ISO)

negative regulation of transforming growth factor beta receptor signaling pathway (IGI)

nodal signaling pathway (IBA,IGI,IMP)

peptidyl-serine phosphorylation (ISO)

positive regulation of cell migration (IDA,ISO)

positive regulation of cell population proliferation (ISO)

positive regulation of cell-matrix adhesion (IMP)

positive regulation of endothelial cell migration (ISO)

positive regulation of fibroblast proliferation (IMP)

positive regulation of peptidyl-tyrosine phosphorylation (ISO)

positive regulation of transcription by RNA polymerase II (IGI)

regulation of cell migration (IMP)

regulation of signal transduction (IDA,ISO)

vasculogenesis (IMP)

Cellular Component

anchored component of membrane (IEA)

apical plasma membrane (ISO)

cell surface (IBA,IDA,ISO)

cytoplasm (IDA)

extracellular region (IBA,IDA)

extracellular space (IDA,ISO)

extrinsic component of plasma membrane (IDA)

Golgi apparatus (IDA)

membrane (IEA)

membrane raft (ISO)

nucleus (IDA)

perinuclear region of cytoplasm (IDA)

plasma membrane (IEA,TAS)

Molecular Function

activin receptor binding (IBA)

coreceptor activity (IDA)

growth factor activity (ISO)

nodal binding (IBA,IPI)

protein binding (IPI)

signaling receptor binding (IBA,ISO)

type I activin receptor binding (IPI)

Wnt-protein binding (IPI)

Molecular Pathway Annotations Click to see Annotation Detail View

glypican signaling pathway (ISO)

Phenotype Annotations Click to see Annotation Detail View

Mammalian Phenotype

abnormal amnion morphology (IAGP)

abnormal cell adhesion (IAGP)

abnormal chorion morphology (IAGP)

abnormal developmental patterning (IAGP)

abnormal embryo turning (IAGP)

abnormal embryonic neuroepithelium morphology (IAGP)

abnormal embryonic tissue morphology (IAGP)

abnormal endoderm development (IAGP)

abnormal extraembryonic tissue morphology (IAGP)

abnormal gastrulation (IAGP)

abnormal germ layer development (IAGP)

abnormal heart development (IAGP)

abnormal heart morphology (IAGP)

abnormal mesendoderm development (IAGP)

abnormal mesoderm development (IAGP)

abnormal neural fold morphology (IAGP)

abnormal primitive streak formation (IAGP)

abnormal rostral-caudal axis patterning (IAGP)

abnormal visceral endoderm morphology (IAGP)

abnormal visceral yolk sac blood island morphology (IAGP)

absent anterior definitive endoderm (IAGP)

absent mesoderm (IAGP)

absent notochord (IAGP)

absent prechordal plate (IAGP)

absent somites (IAGP)

absent vitelline blood vessels (IAGP)

cyclopia (IAGP)

decreased fibroblast proliferation (IAGP)

decreased forebrain size (IAGP)

decreased midbrain size (IAGP)

embryonic growth arrest (IAGP)

embryonic lethality during organogenesis, complete penetrance (IAGP)

embryonic lethality, complete penetrance (IAGP)

failure of primitive streak formation (IAGP)

fused somites (IAGP)

holoprosencephaly (IAGP)

no abnormal phenotype detected (IAGP)

premature death (IAGP)

rostral body truncation (IAGP)

short rostral-caudal axis (IAGP)

References

References - curated


1.	Lonardo E, etal., Stem Cells. 2010 Aug;28(8):1326-37. doi: 10.1002/stem.458.
2.	OMIM Disease Annotation Pipeline
3.	Pipeline to import Pathway Interaction Database annotations from NCI into RGD
4.	RGD automated import pipeline
5.	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
6.	RGD automated import pipeline for gene-chemical interactions
7.	Wang B, etal., Int J Cardiol. 2011 Jan 21;146(2):225-7. doi: 10.1016/j.ijcard.2009.08.046. Epub 2009 Oct 24.
8.	Xing PX, etal., Cancer Res. 2004 Jun 1;64(11):4018-23.

Additional References at PubMed

PMID:2792079	PMID:7588062	PMID:7881126	PMID:7916676	PMID:8006041	PMID:8588926	PMID:8661720	PMID:9013573	PMID:9053319	PMID:9195995	PMID:9576836	PMID:9790191
PMID:9811942	PMID:9876177	PMID:10349636	PMID:10477299	PMID:10640699	PMID:10772805	PMID:10922068	PMID:10985852	PMID:11042159	PMID:11076861	PMID:11133982	PMID:11171400
PMID:11217851	PMID:11389842	PMID:11412024	PMID:11418863	PMID:11807813	PMID:11820816	PMID:11825688	PMID:11857442	PMID:11992720	PMID:12052855	PMID:12091315	PMID:12093914
PMID:12140191	PMID:12381664	PMID:12447384	PMID:12466851	PMID:12471260	PMID:12477932	PMID:12520002	PMID:12581525	PMID:12904583	PMID:14502576	PMID:14511481	PMID:14581455
PMID:14610273	PMID:14623818	PMID:14633973	PMID:14651936	PMID:14668413	PMID:14966532	PMID:15277382	PMID:15302604	PMID:15601854	PMID:15737733	PMID:15797385	PMID:15829518
PMID:15870281	PMID:15897912	PMID:16049342	PMID:16141072	PMID:16141073	PMID:16176936	PMID:16256739	PMID:16291788	PMID:16291790	PMID:16368929	PMID:16481355	PMID:16580991
PMID:16728477	PMID:16831833	PMID:16887818	PMID:16950123	PMID:17030617	PMID:17360443	PMID:17389379	PMID:17568773	PMID:17697936	PMID:17699604	PMID:17913787	PMID:17936261
PMID:17941089	PMID:17967808	PMID:17991893	PMID:18028899	PMID:18089557	PMID:18171685	PMID:18241853	PMID:18268105	PMID:18337457	PMID:18425773	PMID:18697220	PMID:18772886
PMID:18773496	PMID:18781635	PMID:18799693	PMID:18974875	PMID:19001664	PMID:19013461	PMID:19152270	PMID:19153222	PMID:19247965	PMID:19574549	PMID:19605690	PMID:19716815
PMID:19834060	PMID:20007774	PMID:20211162	PMID:20346354	PMID:20359476	PMID:20708584	PMID:20876643	PMID:21267068	PMID:21445260	PMID:21664901	PMID:21731673	PMID:21862554
PMID:21873635	PMID:21896659	PMID:21982233	PMID:22202673	PMID:22542493	PMID:22560297	PMID:22682244	PMID:22872153	PMID:23034635	PMID:23129614	PMID:23473982	PMID:23552073
PMID:23651855	PMID:23747598	PMID:24307303	PMID:24680892	PMID:24805056	PMID:24859004	PMID:24952961	PMID:25446535	PMID:25588837	PMID:25907228	PMID:26059540	PMID:26324715
PMID:26429739	PMID:26534985	PMID:26654129	PMID:26811383	PMID:27521049	PMID:27586544	PMID:27687577	PMID:27881714	PMID:28118982	PMID:28839193	PMID:29168693	PMID:29506220
PMID:31341279	PMID:32876567

Genomics

Comparative Map Data

Tdgf1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	9	110,768,676 - 110,775,226 (-)	NCBI	GRCm39		mm39
GRCm38	9	110,939,608 - 110,946,158 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	9	110,939,603 - 110,946,158 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	9	110,842,112 - 110,848,662 (-)	NCBI	GRCm37		mm9	NCBIm37
MGSCv36	9	110,784,418 - 110,790,883 (-)	NCBI			mm8
Celera	9	110,664,719 - 110,671,594 (-)	NCBI		Celera
Cytogenetic Map	9	F2	NCBI
cM Map	9	60.79	NCBI

TDGF1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38.p13 Ensembl	3	46,574,534 - 46,582,457 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh38	3	46,574,535 - 46,582,457 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh37	3	46,616,045 - 46,623,953 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	3	46,594,217 - 46,598,957 (+)	NCBI	NCBI36		hg18	NCBI36
Build 34	3	46,594,216 - 46,598,954	NCBI
Celera	3	46,553,783 - 46,561,683 (+)	NCBI
Cytogenetic Map	3	p21.31	NCBI
HuRef	3	46,658,557 - 46,666,459 (+)	NCBI		HuRef
CHM1_1	3	46,566,173 - 46,574,073 (+)	NCBI		CHM1_1

Tdgf1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rnor_6.0	8	119,215,266 - 119,220,909 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	8	119,215,495 - 119,219,232 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	8	118,554,829 - 118,560,094 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	8	115,341,587 - 115,346,871 (-)	NCBI	RGSC3.4		rn4	RGSC3.4
Celera	8	110,206,645 - 110,212,260 (-)	NCBI		Celera
Cytogenetic Map	8	q32	NCBI

Tdgf1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955420	25,477,122 - 25,479,969 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955420	25,476,975 - 25,479,969 (-)	NCBI	ChiLan1.0	ChiLan1.0

TDGF1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
PanPan1.1	3	47,577,949 - 47,583,126 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	3	47,577,949 - 47,583,126 (+)	Ensembl	panpan1.1		panPan2
Mhudiblu_PPA_v0	3	46,473,282 - 46,478,454 (+)	NCBI	Mhudiblu_PPA_v0		panPan3

TDGF1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	20	42,137,939 - 42,140,590 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1

Tdgf1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
SpeTri2.0	NW_004936596	451,483 - 453,892 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

TDGF1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	13	29,540,314 - 29,543,893 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	13	29,537,874 - 29,544,686 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	13	32,774,947 - 32,777,177 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

TDGF1
(Chlorocebus sabaeus - African green monkey)

Vervet Assembly	Chr	Position (strand)	Source	Genome Browsers
Vervet Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	22	7,993,724 - 8,000,935 (+)	NCBI
ChlSab1.1 Ensembl	22	7,997,383 - 8,000,629 (+)	Ensembl

Tdgf1
(Heterocephalus glaber - naked mole-rat)

Molerat Assembly	Chr	Position (strand)	Source	Genome Browsers
Molerat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624730	74,547,226 - 74,550,526 (-)	NCBI

Position Markers

M87321

Mouse Assembly	Chr	Position (strand)	Source	JBrowse
Cytogenetic Map	9	F3	UniSTS
cM Map	9	60.0	UniSTS

UniSTS:236264

Mouse Assembly	Chr	Position (strand)	Source	JBrowse
GRCm38	9	110,944,452 - 110,944,752	UniSTS	GRCm38
MGSCv37	9	110,846,956 - 110,847,256	UniSTS	GRCm37
Celera	9	110,669,890 - 110,670,190	UniSTS
Cytogenetic Map	9	F3	UniSTS
cM Map	9	60.0	UniSTS

Tdgf1

Mouse Assembly	Chr	Position (strand)	Source	JBrowse
GRCm38	9	110,939,741 - 110,940,083	UniSTS	GRCm38
MGSCv37	9	110,842,245 - 110,842,587	UniSTS	GRCm37
Celera	9	110,664,852 - 110,665,194	UniSTS
Cytogenetic Map	9	F3	UniSTS
cM Map	9	60.0	UniSTS

Tdgf1

Mouse Assembly	Chr	Position (strand)	Source	JBrowse
GRCm38	9	110,942,647 - 110,942,888	UniSTS	GRCm38
MGSCv37	9	110,845,151 - 110,845,392	UniSTS	GRCm37
Celera	9	110,667,760 - 110,668,001	UniSTS
Cytogenetic Map	9	F3	UniSTS
cM Map	9	60.0	UniSTS

QTLs in Region (GRCm38)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
4141833	W10q13_m	weight 10 weeks QTL 13 (mouse)			Not determined			63332429	120362868	Mouse
12904947	Tammq7_m	tibialis anterior muscle mass QTL 7 (mouse)					9	91683173	124595110	Mouse
13463478	Mchq18_m	mean corpuscular hemoglobin QTL 18 (mouse)					9	91641084	124595110	Mouse
1302001	Bdln5_m	body length 5 (mouse)			Not determined		9	93762590	124595110	Mouse
13463474	Hbbcq5_m	hemoglobin concentration QTL 5 (mouse)					9	91641084	124595110	Mouse
10054492	El7_m	epilepsy 7 (mouse)			Not determined		9	75775364	114474379	Mouse
12910772	Lvic6_m	liver iron content 6 (mouse)					9	91413879	124595110	Mouse
1357461	Idd2_m	insulin dependent diabetes susceptibility 2 (mouse)			Not determined		9	82910333	116910428	Mouse
11081166	Psl5_m	promotion susceptibility QTL 5 (mouse)					9	94981301	112872929	Mouse
1357627	Tgq2_m	triglyceride QTL 2 (mouse)			Not determined		9	102000187	124595110	Mouse
1302103	Dob2_m	dietary obesity 2 (mouse)			Not determined		9	86239845	120289624	Mouse
1301192	Skts6_m	skin tumor susceptibility 6 (mouse)			Not determined		9	78640645	112640755	Mouse
13463477	Rbc9_m	red blood cell count 9 (mouse)					9	91641084	124595110	Mouse
10412290	Pvacm1l_m	plasma vascular cell adhesion molecule 1 levels (mouse)			Not determined		9	103289445	124595110	Mouse
10766454	Char10_m	P. chabaudi malaria resistance QTL 10 (mouse)					9	82910333	116910428	Mouse
1357635	Splq4_m	spleen weight QTL 4 (mouse)			Not determined		9	63332429	120362868	Mouse
1357657	Pymr_m	Plasmodium yoelli malaria resistance (mouse)			Not determined		9	89977005	118938021	Mouse
10412242	Alpq8_m	alcohol preference QTL 8 (mouse)			Not determined		9	89284925	123284925	Mouse
1300549	Bbaa17_m	B. burgdorferi-associated arthritis 17 (mouse)			Not determined		9	86230401	120230530	Mouse
12904961	Gmmq7_m	gastrocnemius muscle mass QTL 7 (mouse)					9	91683173	124595110	Mouse
1558767	Skmw11_m	skeletal muscle weight 11 (mouse)			Not determined		9	91641084	124595110	Mouse
13463480	Mchcq2_m	mean corpuscular hemoglobin concentration QTL 2 (mouse)					9	91641084	124595110	Mouse
12910773	Splic3_m	spleen iron content 3 (mouse)					9	91413879	124595110	Mouse
12879896	Berr3_m	berghei resistance locus 3 (mouse)					9	103289445	124595110	Mouse
11537364	Cnes5_m	C. neoformans susceptibility locus 5 (mouse)					9	96917590	124595110	Mouse
14746992	Manh67_m	mandible shape 67 (mouse)					9	94036768	124595110	Mouse
10401247	Bglu14_m	blood glucose level 14 (mouse)			Not determined		9	79397810	113397888	Mouse
4141545	Tailaq2_m	tail length adjusted QTL 2 (mouse)			Not determined			63332429	120362868	Mouse
1300884	Sluc11_m	susceptibility to lung cancer 11 (mouse)			Not determined		9	82910333	116910428	Mouse
1302065	El1_m	epilepsy 1 (mouse)			Not determined		9	75775364	114474379	Mouse
1301732	Char1_m	P. chabaudi malaria resistance QTL 1 (mouse)			Not determined		9	81798268	115798392	Mouse
1301789	Pbwg4_m	postnatal body weight growth 4 (mouse)			Not determined		9	103289445	124595110	Mouse
18182932	Metl3_m	metabolite locus 3, N-acetylglutamate (mouse)					9	89563342	123563342	Mouse
11251716	Siim2_m	stress induced immobility 2 (mouse)					9	86748483	120748483	Mouse
12880422	V25Dq6_m	vitamin D inactive form serum level QTL 6 (mouse)					9	87800000	121800000	Mouse
1357648	Obq18_m	obesity QTL 18 (mouse)			Not determined		9	102000187	124595110	Mouse
1301487	Nociq1_m	nociceptive sensitivity inflammatory QTL 1 (mouse)			Not determined		9	84528818	118528921	Mouse
1301297	Lcho1_m	liver cholesterol 1 (mouse)			Not determined		9	101060861	124595110	Mouse
1301649	Psl1_m	promotion susceptibility QTL 1 (mouse)			Not determined		9	89412277	123412396	Mouse
12910770	Splic1_m	spleen iron content 1 (mouse)					9	91413879	124595110	Mouse
1301484	Bwq6_m	body weight (mouse)			Not determined		9	93762590	124595110	Mouse
13463475	Hctq7_m	hematocrit QTL 7 (mouse)					9	91641084	124595110	Mouse
13515058	Adip20d_m	adiposity 20d (mouse)					9	108915010	118915010	Mouse
12904937	Edlmmq9_m	extensor digitorum longus muscle mass QTL 9 (mouse)					9	91683173	124595110	Mouse

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	275
Count of miRNA genes:	234
Interacting mature miRNAs:	246
Transcripts:	ENSMUST00000035075
Prediction methods:	Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_011562	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017313275	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC118727	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AC139378	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK133730	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK163969	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC052646	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH466621	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CJ074826	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	M87321	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	X93470	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	X94083	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

ENSMUST00000035075 ⟹ ENSMUSP00000035075

RefSeq Status:

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm38.p6 Ensembl	9	110,939,603 - 110,946,158 (-)	Ensembl

RefSeq Acc Id:

ENSMUST00000197460 ⟹ ENSMUSP00000143394

RefSeq Status:

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm38.p6 Ensembl	9	110,940,243 - 110,946,094 (-)	Ensembl

RefSeq Acc Id:

ENSMUST00000199196 ⟹ ENSMUSP00000142397

RefSeq Status:

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm38.p6 Ensembl	9	110,942,642 - 110,944,871 (-)	Ensembl

RefSeq Acc Id:

ENSMUST00000199782 ⟹ ENSMUSP00000143669

RefSeq Status:

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm38.p6 Ensembl	9	110,942,357 - 110,946,075 (-)	Ensembl

RefSeq Acc Id:

NM_011562 ⟹ NP_035692

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39	9	110,768,676 - 110,775,226 (-)	NCBI
GRCm38	9	110,939,608 - 110,946,158 (-)	ENTREZGENE
MGSCv37	9	110,842,112 - 110,848,662 (-)	RGD
Celera	9	110,664,719 - 110,671,594 (-)	RGD
cM Map	9		ENTREZGENE

Sequence:

show sequence

ACCTGAGGGTCCTACTCAACACCTTAAGTTTCTTTTAAGGGAGGTATATTCCTCCGAAGTCCTC
AATCACAAACCGTTTATAGGAAGAAGAGGCCCCATCCCCTGCCGGTCTACACGGAGATCTTGGC
TGCTAACTTCCCACAGACTCTCCAGGACGGGGGCCTCTCTCATTTGGCATATCTTTCTTTTTAA
TCTACTGTTTTCATTTTGTGAAATTAGCCTTTGGGTGTTTCGAGAATGGCTTTATGAACTAAAG
CCATCTGCTAATATTGTGTTTCTTGTCTTTTCCTCCAACGTTTTTACGAGCCGTCGAAGATGGG
GTACTTCTCATCCAGTGTGGTTTTGCTTGTGGCCATTTCCAGTGCGTTTGAATTTGGACCCGTT
GCTGGGAGAGACCTTGCCATCAGAGATAACAGCATTTGGGACCAGAAAGAACCTGCCGTACGCG
ATCGGTCTTTCCAGTTTGTGCCTTCCGTGGGGATACAGAACAGTAAGTCGCTTAATAAAACTTG
CTGTCTGAATGGAGGGACTTGCATCCTGGGGTCCTTCTGTGCCTGCCCTCCTTCCTTCTATGGA
CGCAACTGTGAACATGATGTTCGCAAAGAGCACTGTGGGTCTATCCTCCATGGCACCTGGCTGC
CCAAGAAGTGTTCCCTGTGCAGATGCTGGCACGGCCAGCTCCACTGTCTTCCTCAGACCTTTCT
ACCTGGCTGTGATGGTCACGTGATGGACCAGGACCTCAAAGCATCCGGGACTCCGTGTCAAACG
CCGTCTGTGACGACCACTTTTATGCTAGCTGGCGCCTGCCTTTTTCTAGATATGAAAGTATAGG
TGTCATGTGAATTCCATGCCAGTGCCATAGCAAAGATGTCATTCATCTTGATGCTCACAGTGAA
TCCCTAATGTTACCCCTCAAAACACTAACTAGGCCTTACCTCTGCACAGCCCCTCCTCTTTCTG
GAAAACTATGGCGTGTGTGCCAAGCACTGTAACAGCGAGTTACATTCCTAGCCTAAAAGCTACT
CTAAGAATGTGCTGTCTGCCATAGCCTGAGTTTCTTGATAGAAGTAACTCTCTTACTTTTCTTC
CTAAGACTTTTAAACAGTTCTGAAGGTTATTATTAAATCCCAATGTGCAACTGGAAGTAAATTC
AGAGTAGCTGAAAACAGCTAAATTATCTTTAAGCAGGGAGGTGGTGGTGTCTACCTTAAATCAG
GCAAAGGCAGGTATATTTCTTGAGTTCCAGGACAGACAGGCCTACACAGAAACCCTGTCTCGGG
GAGAAAAAAGAGAGAGAGAGAAGAAAAACTATTATCTTAAAAGAAAATTAATGGACCAGGCATT
GTGGCAGATGGCTTTAATCCCAGCCCTCAGGAGGTAGGGATAGGAGGATCTCAAGAGTTCAAGG
CCAGCCTGGTCTATGTAGCGAACCCCTGTCTCAAAAAGGAAAAAGCATCCTACGAGGGAGTTGA
GGAAGTAATGAGGGTCTGTGCAGAGGGAGCAGCAGATGGGGAAGTGACTAAGACTGGGGAAACA
GAGTGGATTGTTTGATTGATGTTTACGGAGGTACTGGGAATTTAAAAGCTAAGTTCTTCAGCCA
AGCACAGTGGTGCACACTATTAATGTCAGCTCTCAGGAGGCTACAACAGGACTACTAAAAGCTC
ATGTCCAACCTGGGCTATGTACAGAGTACCAGGCCAACAAAGACTGAATGGCAAGACCCTCACA
GAAAACCCAAACACCCGAGTCTCTTTTCTGCAAAAGTACGAAGGCTTTCTCCAAGCTATATACA
ATTATTCAACTGTTGTGGAGGAAAGAAAGTGTTTATTATTGTAGTAGTAAACCAGATTATAAAA
ACCACGTATTGTCAAGTCAGTTTTTATAATAATTGTTCATGAATATGCACAGTAAAAATGGGAA
CTCTGAAAAAAAAAAAAAAAAAAAAAAA

hide sequence

RefSeq Acc Id:

XM_017313275 ⟹ XP_017168764

RefSeq Status:

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39	9	110,768,676 - 110,771,993 (-)	NCBI
GRCm38	9	110,939,608 - 110,942,925 (-)	NCBI

Sequence:

show sequence

AGAGAGAGAGGGAGAGAGAGAGAGAGGGAGAGGGAATGTCCCTGATAGTCTCTGATACTCAGTT
TCTCTCCTGATGCCACTTCATGCTGGGACCAGCTATCAGACCATCAGACTAGGTGACCAATCTG
GTCCAACCATGAAAGTTATTTCCCTGAAAGGTAAGTCGCTTAATAAAACTTGCTGTCTGAATGG
AGGGACTTGCATCCTGGGGTCCTTCTGTGCCTGCCCTCCTTCCTTCTATGGACGCAACTGTGAA
CATGATGTTCGCAAAGAGCACTGTGGGTCTATCCTCCATGGCACCTGGCTGCCCAAGAAGTGTT
CCCTGTGCAGATGCTGGCACGGCCAGCTCCACTGTCTTCCTCAGACCTTTCTACCTGGCTGTGA
TGGTCACGTGATGGACCAGGACCTCAAAGCATCCGGGACTCCGTGTCAAACGCCGTCTGTGACG
ACCACTTTTATGCTAGCTGGCGCCTGCCTTTTTCTAGATATGAAAGTATAGGTGTCATGTGAAT
TCCATGCCAGTGCCATAGCAAAGATGTCATTCATCTTGATGCTCACAGTGAATCCCTAATGTTA
CCCCTCAAAACACTAACTAGGCCTTACCTCTGCACAGCCCCTCCTCTTTCTGGAAAACTATGGC
GTGTGTGCCAAGCACTGTAACAGCGAGTTACATTCCTAGCCTAAAAGCTACTCTAAGAATGTGC
TGTCTGCCATAGCCTGAGTTTCTTGATAGAAGTAACTCTCTTACTTTTCTTCCTAAGACTTTTA
AACAGTTCTGAAGGTTATTATTAAATCCCAATGTGCAACTGGAAGTAAATTCAGAGTAGCTGAA
AACAGCTAAATTATCTTTAAGCAGGGAGGTGGTGGTGTCTACCTTAAATCAGGCAAAGGCAGGT
ATATTTCTTGAGTTCCAGGACAGACAGGCCTACACAGAAACCCTGTCTCGGGGAGAAAAAAGAG
AGAGAGAGAAGAAAAACTATTATCTTAAAAGAAAATTAATGGACCAGGCATTGTGGCAGATGGC
TTTAATCCCAGCCCTCAGGAGGTAGGGATAGGAGGATCTCAAGAGTTCAAGGCCAGCCTGGTCT
ATGTAGCGAACCCCTGTCTCAAAAAGGAAAAAGCATCCTACGAGGGAGTTGAGGAAGTAATGAG
GGTCTGTGCAGAGGGAGCAGCAGATGGGGAAGTGACTAAGACTGGGGAAACAGAGTGGATTGTT
TGATTGATGTTTACGGAGGTACTGGGAATTTAAAAGCTAAGTTCTTCAGCCAAGCACAGTGGTG
CACACTATTAATGTCAGCTCTCAGGAGGCTACAACAGGACTACTAAAAGCTCATGTCCAACCTG
GGCTATGTACAGAGTACCAGGCCAACAAAGACTGAATGGCAAGACCCTCACAGAAAACCCAAAC
ACCCGAGTCTCTTTTCTGCAAAAGTACGAAGGCTTTCTCCAAGCTATATACAATTATTCAACTG
TTGTGGAGGAAAGAAAGTGTTTATTATTGTAGTAGTAAACCAGATTATAAAAACCACGTATTGT
CAAGTCAGTTTTTATAATAATTGTTCATGAATATGCACAGTAAAAATGGGAACTCTGAA

hide sequence

Protein Sequences


Protein RefSeqs	NP_035692	(Get FASTA)	NCBI Sequence Viewer
	XP_017168764	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAA37459	(Get FASTA)	NCBI Sequence Viewer
	AAH52646	(Get FASTA)	NCBI Sequence Viewer
	BAE21807	(Get FASTA)	NCBI Sequence Viewer
	CAA63827	(Get FASTA)	NCBI Sequence Viewer
	EDL08985	(Get FASTA)	NCBI Sequence Viewer
	P51865	(Get FASTA)	NCBI Sequence Viewer

Reference Sequences

RefSeq Acc Id:	NP_035692 ⟸ NM_011562
- Peptide Label:	precursor
- UniProtKB:	Q3UZP8 (UniProtKB/TrEMBL), Q7TQ06 (UniProtKB/TrEMBL)
- Sequence:	show sequence MGYFSSSVVLLVAISSAFEFGPVAGRDLAIRDNSIWDQKEPAVRDRSFQFVPSVGIQNSKSLNK TCCLNGGTCILGSFCACPPSFYGRNCEHDVRKEHCGSILHGTWLPKKCSLCRCWHGQLHCLPQT FLPGCDGHVMDQDLKASGTPCQTPSVTTTFMLAGACLFLDMKV hide sequence

RefSeq Acc Id:	XP_017168764 ⟸ XM_017313275
- Peptide Label:	isoform X1
- Sequence:	show sequence MPLHAGTSYQTIRLGDQSGPTMKVISLKGKSLNKTCCLNGGTCILGSFCACPPSFYGRNCEHDV RKEHCGSILHGTWLPKKCSLCRCWHGQLHCLPQTFLPGCDGHVMDQDLKASGTPCQTPSVTTTF MLAGACLFLDMKV hide sequence

RefSeq Acc Id:

ENSMUSP00000143394 ⟸ ENSMUST00000197460

RefSeq Acc Id:

ENSMUSP00000035075 ⟸ ENSMUST00000035075

RefSeq Acc Id:

ENSMUSP00000143669 ⟸ ENSMUST00000199782

RefSeq Acc Id:

ENSMUSP00000142397 ⟸ ENSMUST00000199196

Protein Domains

EGF-like

Promoters

RGD ID:

6848484

Promoter ID:

MM_ACW:52163

Type:

Non-CpG

SO ACC ID:

SO:0000170

Source:

MPROMDB

Tissues & Cell Lines:

ES_Cell

Transcripts:

TDGF1.ESEP07

Position:

Mouse Assembly	Chr	Position (strand)	Source
MGSCv36	9	110,846,851 - 110,847,351 (-)	MPROMDB

RGD ID:

6845237

Promoter ID:

MM_KWN:58950

Type:

CpG-Island

SO ACC ID:

SO:0000170

Source:

MPROMDB

Tissues & Cell Lines:

ES_Cell

Transcripts:

ENSMUST00000035075, NM_011562

Position:

Mouse Assembly	Chr	Position (strand)	Source
MGSCv36	9	110,848,551 - 110,849,392 (-)	MPROMDB

RGD ID:

8671042

Promoter ID:

EPDNEW_M13552

Type:

initiation region

Name:

Tdgf1_1

Description:

Mus musculus teratocarcinoma-derived growth factor 1 , mRNA.

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm38	9	110,946,094 - 110,946,154	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	MGI:98658	AgrOrtholog
Ensembl Genes	ENSMUSG00000032494	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein	ENSMUSP00000035075	ENTREZGENE, UniProtKB/TrEMBL
	ENSMUSP00000142397	UniProtKB/TrEMBL
	ENSMUSP00000143394	UniProtKB/TrEMBL
	ENSMUSP00000143669	UniProtKB/TrEMBL
Ensembl Transcript	ENSMUST00000035075	ENTREZGENE, UniProtKB/TrEMBL
	ENSMUST00000197460	UniProtKB/TrEMBL
	ENSMUST00000199196	UniProtKB/TrEMBL
	ENSMUST00000199782	UniProtKB/TrEMBL
InterPro	Cripto_growth_factor	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Cryptic/Cripto_CFC-dom	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	EGF-like_dom	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	mmu:21667	UniProtKB/TrEMBL
MGD	MGI:98658	ENTREZGENE
NCBI Gene	21667	ENTREZGENE
Pfam	CFC	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Tdgf1	PhenoGen
PIRSF	Cripto_growth_factor	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE	EGF_1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	EGF_3	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniGene	Mm.5090	ENTREZGENE
UniProt	A0A0G2JDJ9_MOUSE	UniProtKB/TrEMBL
	A0A0G2JG22_MOUSE	UniProtKB/TrEMBL
	A0A0G2JGR6_MOUSE	UniProtKB/TrEMBL
	P51865	ENTREZGENE
	Q3UZP8	ENTREZGENE, UniProtKB/TrEMBL
	Q7TQ06	ENTREZGENE, UniProtKB/TrEMBL
	TDGF1_MOUSE	UniProtKB/Swiss-Prot

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Annotations - PID (archival)