Cripto (cripto, EGF-CFC family member) - Rat Genome Database

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Gene: Cripto (cripto, EGF-CFC family member) Mus musculus
Analyze
Symbol: Cripto (Ensembl: Tdgf1)
Name: cripto, EGF-CFC family member (Ensembl:teratocarcinoma-derived growth factor 1)
RGD ID: 1617601
MGI Page MGI
Description: Enables several functions, including Wnt-protein binding activity; coreceptor activity; and nodal binding activity. Involved in several processes, including morphogenesis of a branching structure; nodal signaling pathway; and positive regulation of cell migration. Acts upstream of or within several processes, including circulatory system development; negative regulation of transforming growth factor beta receptor signaling pathway; and positive regulation of fibroblast proliferation. Located in several cellular components, including Golgi apparatus; cell surface; and perinuclear region of cytoplasm. Is expressed in several structures, including blastocyst; brain; extraembryonic component; gonad; and heart. Human ortholog(s) of this gene implicated in colon cancer and congenital heart disease. Orthologous to several human genes including CRIPTO (cripto, EGF-CFC family member).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: cr; CR1; cripto growth factor; epidermal growth factor-like Cripto protein; Tdgf1; teratocarcinoma-derived growth factor; teratocarcinoma-derived growth factor 1; TERATOCARCINOMA-DERIVED GROWTH FACTOR PRECURSOR (EPIDERMAL GROWTH FACTOR-LIKE CRIPTO PROTEIN) (CRIPTO GROWTH FACTOR)
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Related Pseudogenes: Tdgf1-ps1   Tdgf1-ps2  
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm399110,768,676 - 110,775,226 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl9110,768,671 - 110,775,226 (-)EnsemblGRCm39 Ensembl
GRCm389110,939,608 - 110,946,158 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl9110,939,603 - 110,946,158 (-)EnsemblGRCm38mm10GRCm38
MGSCv379110,842,112 - 110,848,662 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv369110,784,418 - 110,790,883 (-)NCBIMGSCv36mm8
Celera9110,664,719 - 110,671,594 (-)NCBICelera
Cytogenetic Map9F2NCBI
cM Map960.79NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
anterior/posterior axis specification  (IGI)
anterior/posterior axis specification, embryo  (IMP)
anterior/posterior pattern specification  (IBA)
blood vessel development  (IBA)
cardiac muscle cell differentiation  (IMP)
cell differentiation  (TAS)
cell migration involved in sprouting angiogenesis  (ISO)
cellular response to epidermal growth factor stimulus  (ISO)
cellular response to fibroblast growth factor stimulus  (ISO)
cellular response to hepatocyte growth factor stimulus  (ISO)
cellular response to interleukin-6  (ISO)
cellular response to tumor necrosis factor  (ISO)
cellular response to type II interferon  (ISO)
determination of left/right symmetry  (IBA)
epidermal growth factor receptor signaling pathway  (ISO)
fibroblast proliferation  (IMP)
gastrulation  (IGI)
heart development  (IBA,IDA)
in utero embryonic development  (IMP)
morphogenesis of a branching structure  (IDA)
negative regulation of apoptotic process  (ISO)
negative regulation of transforming growth factor beta receptor signaling pathway  (IGI)
nodal signaling pathway  (IBA,IGI,IMP)
positive regulation of cell migration  (IDA)
positive regulation of cell population proliferation  (ISO)
positive regulation of cell-matrix adhesion  (IMP)
positive regulation of endothelial cell migration  (ISO)
positive regulation of fibroblast proliferation  (IMP)
positive regulation of MAPK cascade  (ISO)
positive regulation of peptidyl-tyrosine phosphorylation  (ISO)
positive regulation of transcription by RNA polymerase II  (IGI)
regulation of fibroblast migration  (IMP)
regulation of signal transduction  (IDA,ISO)
vasculogenesis  (IMP)

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal amnion morphology  (IAGP)
abnormal cell adhesion  (IAGP)
abnormal chorion morphology  (IAGP)
abnormal decidualization  (IAGP)
abnormal developmental patterning  (IAGP)
abnormal embryo attachment  (IAGP)
abnormal embryo turning  (IAGP)
abnormal embryonic neuroepithelium morphology  (IAGP)
abnormal embryonic tissue morphology  (IAGP)
abnormal endoderm development  (IAGP)
abnormal endometrial gland morphology  (IAGP)
abnormal extraembryonic tissue morphology  (IAGP)
abnormal gastrulation  (IAGP)
abnormal germ layer development  (IAGP)
abnormal heart development  (IAGP)
abnormal heart morphology  (IAGP)
abnormal luminal closure  (IAGP)
abnormal mesendoderm development  (IAGP)
abnormal mesoderm development  (IAGP)
abnormal neural fold morphology  (IAGP)
abnormal pregnancy  (IAGP)
abnormal primitive streak formation  (IAGP)
abnormal rostral-caudal axis patterning  (IAGP)
abnormal uterine environment  (IAGP)
abnormal uterine-embryonic axis  (IAGP)
abnormal visceral endoderm morphology  (IAGP)
abnormal visceral yolk sac blood island morphology  (IAGP)
absent anterior definitive endoderm  (IAGP)
absent mesoderm  (IAGP)
absent notochord  (IAGP)
absent prechordal plate  (IAGP)
absent somites  (IAGP)
absent vitelline blood vessels  (IAGP)
cyclopia  (IAGP)
decreased fibroblast proliferation  (IAGP)
decreased forebrain size  (IAGP)
decreased litter size  (IAGP)
decreased midbrain size  (IAGP)
delayed embryo implantation  (IAGP)
embryonic growth arrest  (IAGP)
embryonic lethality during organogenesis, complete penetrance  (IAGP)
embryonic lethality, complete penetrance  (IAGP)
endometrium inflammation  (IAGP)
failure of embryo implantation  (IAGP)
failure of primitive streak formation  (IAGP)
female infertility  (IAGP)
fused somites  (IAGP)
holoprosencephaly  (IAGP)
no abnormal phenotype detected  (IAGP)
premature death  (IAGP)
reduced female fertility  (IAGP)
rostral body truncation  (IAGP)
short rostral-caudal axis  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. A small synthetic cripto blocking Peptide improves neural induction, dopaminergic differentiation, and functional integration of mouse embryonic stem cells in a rat model of Parkinson's disease. Lonardo E, etal., Stem Cells. 2010 Aug;28(8):1326-37. doi: 10.1002/stem.458.
2. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
3. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
4. Mouse MP Annotation Import Pipeline RGD automated import pipeline
5. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
7. Teratocarcinoma-derived growth factor 1 (TDGF1) sequence variants in patients with congenital heart defect. Wang B, etal., Int J Cardiol. 2011 Jan 21;146(2):225-7. doi: 10.1016/j.ijcard.2009.08.046. Epub 2009 Oct 24.
8. Cripto: a novel target for antibody-based cancer immunotherapy. Xing PX, etal., Cancer Res. 2004 Jun 1;64(11):4018-23.
Additional References at PubMed
PMID:2792079   PMID:7588062   PMID:7881126   PMID:7916676   PMID:8006041   PMID:8588926   PMID:8661720   PMID:9013573   PMID:9053319   PMID:9195995   PMID:9576836   PMID:9790191  
PMID:9811942   PMID:9876177   PMID:10349636   PMID:10477299   PMID:10640699   PMID:10772805   PMID:10922068   PMID:10985852   PMID:11042159   PMID:11076861   PMID:11133982   PMID:11171400  
PMID:11217851   PMID:11389842   PMID:11412024   PMID:11418863   PMID:11807813   PMID:11820816   PMID:11825688   PMID:11857442   PMID:11992720   PMID:12052855   PMID:12091315   PMID:12093914  
PMID:12140191   PMID:12381664   PMID:12447384   PMID:12466851   PMID:12471260   PMID:12477932   PMID:12520002   PMID:12581525   PMID:12904583   PMID:14502576   PMID:14511481   PMID:14581455  
PMID:14610273   PMID:14623818   PMID:14633973   PMID:14651936   PMID:14668413   PMID:14966532   PMID:15277382   PMID:15302604   PMID:15601854   PMID:15737733   PMID:15797385   PMID:15829518  
PMID:15870281   PMID:15897912   PMID:16049342   PMID:16141072   PMID:16141073   PMID:16176936   PMID:16256739   PMID:16291788   PMID:16291790   PMID:16368929   PMID:16481355   PMID:16580991  
PMID:16728477   PMID:16831833   PMID:16887818   PMID:16950123   PMID:17030617   PMID:17360443   PMID:17389379   PMID:17568773   PMID:17697936   PMID:17699604   PMID:17913787   PMID:17936261  
PMID:17941089   PMID:17967808   PMID:17991893   PMID:18028899   PMID:18089557   PMID:18171685   PMID:18241853   PMID:18268105   PMID:18337457   PMID:18425773   PMID:18697220   PMID:18772886  
PMID:18773496   PMID:18781635   PMID:18799693   PMID:18974875   PMID:19001664   PMID:19013461   PMID:19152270   PMID:19153222   PMID:19247965   PMID:19574549   PMID:19605690   PMID:19716815  
PMID:19834060   PMID:20007774   PMID:20211162   PMID:20346354   PMID:20359476   PMID:20708584   PMID:20876643   PMID:21267068   PMID:21445260   PMID:21664901   PMID:21731673   PMID:21862554  
PMID:21873635   PMID:21896659   PMID:21982233   PMID:22202673   PMID:22396454   PMID:22542493   PMID:22560297   PMID:22682244   PMID:22872153   PMID:23034635   PMID:23129614   PMID:23473982  
PMID:23552073   PMID:23651855   PMID:23747598   PMID:24307303   PMID:24680892   PMID:24805056   PMID:24859004   PMID:24952961   PMID:25446535   PMID:25588837   PMID:25907228   PMID:26059540  
PMID:26324715   PMID:26429739   PMID:26534985   PMID:26654129   PMID:26811383   PMID:27521049   PMID:27586544   PMID:27687577   PMID:27881714   PMID:28118982   PMID:28839193   PMID:29168693  
PMID:29506220   PMID:31341279   PMID:32876567   PMID:33590845   PMID:33730615   PMID:34357595   PMID:34517344   PMID:34679163   PMID:34943832   PMID:35729116   PMID:36693128   PMID:37414952  
PMID:37569627   PMID:38056454  


Genomics

Comparative Map Data
Cripto
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm399110,768,676 - 110,775,226 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl9110,768,671 - 110,775,226 (-)EnsemblGRCm39 Ensembl
GRCm389110,939,608 - 110,946,158 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl9110,939,603 - 110,946,158 (-)EnsemblGRCm38mm10GRCm38
MGSCv379110,842,112 - 110,848,662 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv369110,784,418 - 110,790,883 (-)NCBIMGSCv36mm8
Celera9110,664,719 - 110,671,594 (-)NCBICelera
Cytogenetic Map9F2NCBI
cM Map960.79NCBI
CRIPTO
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38346,574,535 - 46,582,457 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl346,574,534 - 46,582,457 (+)EnsemblGRCh38hg38GRCh38
GRCh37346,616,025 - 46,623,947 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36346,594,217 - 46,598,957 (+)NCBINCBI36Build 36hg18NCBI36
Build 34346,594,216 - 46,598,954NCBI
Celera346,553,783 - 46,561,683 (+)NCBICelera
Cytogenetic Map3p21.31NCBI
HuRef346,658,557 - 46,666,459 (+)NCBIHuRef
CHM1_1346,566,173 - 46,574,073 (+)NCBICHM1_1
T2T-CHM13v2.0346,590,623 - 46,598,545 (+)NCBIT2T-CHM13v2.0
Cripto
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr88119,803,182 - 119,808,714 (-)NCBIGRCr8
mRatBN7.28110,924,774 - 110,938,545 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl8110,925,024 - 110,930,308 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.08119,215,266 - 119,220,909 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8119,215,495 - 119,219,232 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.08118,554,829 - 118,560,094 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.48115,341,587 - 115,346,871 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera8110,206,645 - 110,212,260 (-)NCBICelera
Cytogenetic Map8q32NCBI
Cripto
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542025,477,122 - 25,479,969 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542025,476,975 - 25,479,969 (-)NCBIChiLan1.0ChiLan1.0
CRIPTO
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2246,530,938 - 46,535,958 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1346,535,714 - 46,540,728 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0346,473,282 - 46,478,454 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1347,577,949 - 47,583,126 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl347,577,949 - 47,583,126 (+)Ensemblpanpan1.1panPan2
CRIPTO
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12042,137,939 - 42,140,590 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2042,053,910 - 42,056,560 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02042,620,327 - 42,622,979 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2042,620,327 - 42,623,866 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12041,861,683 - 41,864,330 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02042,262,807 - 42,265,458 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02042,543,717 - 42,546,368 (-)NCBIUU_Cfam_GSD_1.0
Cripto
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118200,900,937 - 200,905,070 (+)NCBIHiC_Itri_2
SpeTri2.0NW_004936596451,483 - 453,892 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CRIPTO
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1329,540,314 - 29,543,893 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11329,537,874 - 29,544,686 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21332,774,947 - 32,777,177 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CRIPTO
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1227,993,724 - 8,000,935 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl227,997,383 - 8,000,629 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666041159,149,573 - 159,153,094 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cripto
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462473074,547,226 - 74,550,526 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Cripto
235 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:275
Count of miRNA genes:234
Interacting mature miRNAs:246
Transcripts:ENSMUST00000035075
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4141833W10q13_mweight 10 weeks QTL 13 (mouse)Not determined63239711120191934Mouse
4141545Tailaq2_mtail length adjusted QTL 2 (mouse)Not determined63239711120191934Mouse
1357635Splq4_mspleen weight QTL 4 (mouse)Not determined963239711120191934Mouse
1302065El1_mepilepsy 1 (mouse)Not determined975682646114303447Mouse
10054492El7_mepilepsy 7 (mouse)Not determined975682646114303447Mouse
1301192Skts6_mskin tumor susceptibility 6 (mouse)Not determined978522698112522808Mouse
10401247Bglu14_mblood glucose level 14 (mouse)Not determined979279863113279941Mouse
1301732Char1_mP. chabaudi malaria resistance QTL 1 (mouse)Not determined981680321115680445Mouse
10766454Char10_mP. chabaudi malaria resistance QTL 10 (mouse)982792386116792481Mouse
1300884Sluc11_msusceptibility to lung cancer 11 (mouse)Not determined982792386116792481Mouse
1357461Idd2_minsulin dependent diabetes susceptibility 2 (mouse)Not determined982792386116792481Mouse
1301487Nociq1_mnociceptive sensitivity inflammatory QTL 1 (mouse)Not determined984406017118406120Mouse
1300549Bbaa17_mB. burgdorferi-associated arthritis 17 (mouse)Not determined986107600120107729Mouse
1302103Dob2_mdietary obesity 2 (mouse)Not determined986121898120118690Mouse
11251716Siim2_mstress induced immobility 2 (mouse)986625682120625682Mouse
12880422V25Dq6_mvitamin D inactive form serum level QTL 6 (mouse)987677199121677199Mouse
10412242Alpq8_malcohol preference QTL 8 (mouse)Not determined989162124123162124Mouse
1301649Psl1_mpromotion susceptibility QTL 1 (mouse)Not determined989289476123289595Mouse
18182932Metl3_mmetabolite locus 3, N-acetylglutamate (mouse)989440541123440541Mouse
1357657Pymr_mPlasmodium yoelli malaria resistance (mouse)Not determined989859058118767089Mouse
12910770Splic1_mspleen iron content 1 (mouse)991291078124359700Mouse
12910772Lvic6_mliver iron content 6 (mouse)991291078124359700Mouse
12910773Splic3_mspleen iron content 3 (mouse)991291078124359700Mouse
1558767Skmw11_mskeletal muscle weight 11 (mouse)Not determined991518283124359700Mouse
13463474Hbbcq5_mhemoglobin concentration QTL 5 (mouse)991518283124359700Mouse
13463475Hctq7_mhematocrit QTL 7 (mouse)991518283124359700Mouse
13463477Rbc9_mred blood cell count 9 (mouse)991518283124359700Mouse
13463478Mchq18_mmean corpuscular hemoglobin QTL 18 (mouse)991518283124359700Mouse
13463480Mchcq2_mmean corpuscular hemoglobin concentration QTL 2 (mouse)991518283124359700Mouse
12904937Edlmmq9_mextensor digitorum longus muscle mass QTL 9 (mouse)991560372124359700Mouse
12904947Tammq7_mtibialis anterior muscle mass QTL 7 (mouse)991560372124359700Mouse
12904961Gmmq7_mgastrocnemius muscle mass QTL 7 (mouse)991560372124359700Mouse
1301484Bwq6_mbody weight (mouse)Not determined993591658124359700Mouse
1302001Bdln5_mbody length 5 (mouse)Not determined993591658124359700Mouse
14746992Manh67_mmandible shape 67 (mouse)993865836124359700Mouse
11081166Psl5_mpromotion susceptibility QTL 5 (mouse)994863354112701997Mouse
11537364Cnes5_mC. neoformans susceptibility locus 5 (mouse)996746658124359700Mouse
1301297Lcho1_mliver cholesterol 1 (mouse)Not determined9100889929124359700Mouse
1357648Obq18_mobesity QTL 18 (mouse)Not determined9101829255124359700Mouse
1357627Tgq2_mtriglyceride QTL 2 (mouse)Not determined9101829255124359700Mouse
10412290Pvacm1l_mplasma vascular cell adhesion molecule 1 levels (mouse)Not determined9103118511124359700Mouse
12879896Berr3_mberghei resistance locus 3 (mouse)9103118511124359700Mouse
1301789Pbwg4_mpostnatal body weight growth 4 (mouse)Not determined9103118511124359700Mouse
13515058Adip20d_madiposity 20d (mouse)9108744078118744078Mouse

Markers in Region
M87321  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map9F3UniSTS
cM Map960.0UniSTS
UniSTS:236264  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm389110,944,452 - 110,944,752UniSTSGRCm38
MGSCv379110,846,956 - 110,847,256UniSTSGRCm37
Celera9110,669,890 - 110,670,190UniSTS
Cytogenetic Map9F3UniSTS
cM Map960.0UniSTS
Tdgf1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm389110,939,741 - 110,940,083UniSTSGRCm38
MGSCv379110,842,245 - 110,842,587UniSTSGRCm37
Celera9110,664,852 - 110,665,194UniSTS
Cytogenetic Map9F3UniSTS
cM Map960.0UniSTS
Tdgf1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm389110,942,647 - 110,942,888UniSTSGRCm38
MGSCv379110,845,151 - 110,845,392UniSTSGRCm37
Celera9110,667,760 - 110,668,001UniSTS
Cytogenetic Map9F3UniSTS
cM Map960.0UniSTS


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000035075   ⟹   ENSMUSP00000035075
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl9110,768,671 - 110,775,226 (-)Ensembl
GRCm38.p6 Ensembl9110,939,603 - 110,946,158 (-)Ensembl
RefSeq Acc Id: ENSMUST00000197460   ⟹   ENSMUSP00000143394
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl9110,769,311 - 110,775,162 (-)Ensembl
GRCm38.p6 Ensembl9110,940,243 - 110,946,094 (-)Ensembl
RefSeq Acc Id: ENSMUST00000199196   ⟹   ENSMUSP00000142397
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl9110,771,710 - 110,773,939 (-)Ensembl
GRCm38.p6 Ensembl9110,942,642 - 110,944,871 (-)Ensembl
RefSeq Acc Id: ENSMUST00000199782   ⟹   ENSMUSP00000143669
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl9110,771,425 - 110,775,143 (-)Ensembl
GRCm38.p6 Ensembl9110,942,357 - 110,946,075 (-)Ensembl
RefSeq Acc Id: NM_011562   ⟹   NP_035692
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm399110,768,676 - 110,775,226 (-)NCBI
GRCm389110,939,608 - 110,946,158 (-)ENTREZGENE
MGSCv379110,842,112 - 110,848,662 (-)RGD
Celera9110,664,719 - 110,671,594 (-)RGD
cM Map9 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_017313275   ⟹   XP_017168764
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm399110,768,676 - 110,771,993 (-)NCBI
GRCm389110,939,608 - 110,942,925 (-)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_035692   ⟸   NM_011562
- Peptide Label: precursor
- UniProtKB: P51865 (UniProtKB/Swiss-Prot),   Q3UZP8 (UniProtKB/TrEMBL),   Q7TQ06 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017168764   ⟸   XM_017313275
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSMUSP00000143394   ⟸   ENSMUST00000197460
RefSeq Acc Id: ENSMUSP00000035075   ⟸   ENSMUST00000035075
RefSeq Acc Id: ENSMUSP00000143669   ⟸   ENSMUST00000199782
RefSeq Acc Id: ENSMUSP00000142397   ⟸   ENSMUST00000199196
Protein Domains
EGF-like

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P51865-F1-model_v2 AlphaFold P51865 1-171 view protein structure

Promoters
RGD ID:6848484
Promoter ID:MM_ACW:52163
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:ES_Cell
Transcripts:TDGF1.ESEP07
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv369110,846,851 - 110,847,351 (-)MPROMDB
RGD ID:6845237
Promoter ID:MM_KWN:58950
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:ES_Cell
Transcripts:ENSMUST00000035075,   NM_011562
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv369110,848,551 - 110,849,392 (-)MPROMDB
RGD ID:8671042
Promoter ID:EPDNEW_M13552
Type:initiation region
Name:Tdgf1_1
Description:Mus musculus teratocarcinoma-derived growth factor 1 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm389110,946,094 - 110,946,154EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:98658 AgrOrtholog
Ensembl Genes ENSMUSG00000032494 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000035075 ENTREZGENE
  ENSMUST00000035075.13 UniProtKB/Swiss-Prot
  ENSMUST00000197460.5 UniProtKB/TrEMBL
  ENSMUST00000199196.2 UniProtKB/TrEMBL
  ENSMUST00000199782.2 UniProtKB/TrEMBL
Gene3D-CATH Laminin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Cripto_growth_factor UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cryptic/Cripto_CFC-dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF-like_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:21667 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:98658 ENTREZGENE
NCBI Gene 21667 ENTREZGENE
PANTHER EGF-LIKE-DOMAIN, MULTIPLE 7, 8 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TERATOCARCINOMA-DERIVED GROWTH FACTOR 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam CFC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Cripto PhenoGen
PIRSF Cripto_growth_factor UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE EGF_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP EGF/Laminin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2JDJ9_MOUSE UniProtKB/TrEMBL
  A0A0G2JG22_MOUSE UniProtKB/TrEMBL
  A0A0G2JGR6_MOUSE UniProtKB/TrEMBL
  P51865 ENTREZGENE
  Q3UZP8 ENTREZGENE, UniProtKB/TrEMBL
  Q7TQ06 ENTREZGENE
  TDGF1_MOUSE UniProtKB/Swiss-Prot
UniProt Secondary Q7TQ06 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2023-06-19 Cripto  cripto, EGF-CFC family member  Tdgf1  teratocarcinoma-derived growth factor 1  Symbol and/or name updated 27372883 PROVISIONAL