Egfr (epidermal growth factor receptor) - Rat Genome Database

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Gene: Egfr (epidermal growth factor receptor) Chinchilla lanigera
Symbol: Egfr
Name: epidermal growth factor receptor
RGD ID: 8795990
Description: ENCODES a protein that exhibits actin filament binding (ortholog); calmodulin binding (ortholog); chromatin binding (ortholog); INVOLVED IN activation of MAPKK activity (ortholog); astrocyte activation (ortholog); cell morphogenesis (ortholog); PARTICIPATES IN altered epidermal growth factor/neuregulin signaling pathway; cetuximab pharmacodynamics pathway; E-cadherin signaling pathway; ASSOCIATED WITH acute kidney failure (ortholog); Acute Lung Injury (ortholog); adenocarcinoma (ortholog); FOUND IN apical plasma membrane (ortholog); basolateral plasma membrane (ortholog); cell junction (ortholog)
Type: protein-coding
RefSeq Status: MODEL
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: ChiLan1.0 - Chinchilla ChiLan1.0 Assembly
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0NW_004955456321,222 - 456,431 (-)NCBIChiLan1.0ChiLan1.0
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations     Click to see Annotation Detail View
acute kidney failure  (ISO)
Acute Lung Injury  (ISO)
adenocarcinoma  (ISO)
adrenocortical carcinoma  (ISO)
Alcoholic Liver Diseases  (ISO)
Alzheimer's disease  (ISO)
Animal Mammary Neoplasms  (ISO)
aortic valve stenosis  (ISO)
arteriovenous malformations of the brain  (ISO)
asthma  (ISO)
autistic disorder  (ISO)
autosomal recessive polycystic kidney disease  (ISO)
Bile Duct Neoplasms  (ISO)
Brain Neoplasms  (ISO)
breast cancer  (ISO)
breast carcinoma  (ISO)
Breast Neoplasms  (ISO)
bronchiolo-alveolar adenocarcinoma  (ISO)
carcinoma  (ISO)
Cardiomegaly  (ISO)
Chloracne  (ISO)
cholangiocarcinoma  (ISO)
chronic obstructive pulmonary disease  (ISO)
Colonic Neoplasms  (ISO)
colorectal cancer  (ISO)
Colorectal Neoplasms  (ISO)
Cowden syndrome  (ISO)
Craniofacial Abnormalities  (ISO)
dementia  (ISO)
dermatitis  (ISO)
diabetic retinopathy  (ISO)
dilated cardiomyopathy  (ISO)
Disease Progression  (ISO)
Endometrioid Carcinomas  (ISO)
endometriosis  (ISO)
esophageal carcinoma  (ISO)
Esophageal Neoplasms  (ISO)
esophagus squamous cell carcinoma  (ISO)
Experimental Arthritis  (ISO)
Experimental Diabetes Mellitus  (ISO)
familial adenomatous polyposis  (ISO)
Gallbladder Neoplasms  (ISO)
glioblastoma  (ISO)
Head and Neck Neoplasms  (ISO)
head and neck squamous cell carcinoma  (ISO)
Helicobacter Infections  (ISO)
hepatocellular carcinoma  (ISO)
Hereditary Neoplastic Syndromes  (ISO)
high grade glioma  (ISO)
Huntington's disease  (ISO)
Hyperplasia  (ISO)
hypertension  (ISO)
Immediate Hypersensitivity  (ISO)
Inflammation  (ISO)
Insulin Resistance  (ISO)
Laryngeal Neoplasms  (ISO)
laryngeal squamous cell carcinoma  (ISO)
Left Ventricular Hypertrophy  (ISO)
leiomyoma  (ISO)
liver cirrhosis  (ISO)
lung adenocarcinoma  (ISO)
lung cancer  (ISO)
lung carcinoma  (ISO)
lung disease  (ISO)
Lung Neoplasms  (ISO)
lung non-small cell carcinoma  (ISO)
lung small cell carcinoma  (ISO)
lung squamous cell carcinoma  (ISO)
Lymphatic Metastasis  (ISO)
malignant mesothelioma  (ISO)
Mammary Neoplasms, Experimental  (ISO)
median neuropathy  (ISO)
Mesothelioma  (ISO)
Nasopharyngeal Neoplasms  (ISO)
Neonatal Inflammatory Skin and Bowel Disease 2  (ISO)
Neoplasm Invasiveness  (ISO)
Neoplasm Metastasis  (ISO)
Neoplasm Recurrence, Local  (ISO)
obesity  (ISO)
oral squamous cell carcinoma  (ISO)
osteosarcoma  (ISO)
Ovarian Neoplasms  (ISO)
pancreatic cancer  (ISO)
papilloma  (ISO)
papillomavirus infectious disease  (ISO)
Parkinson's disease  (ISO)
Parkinsonism  (ISO)
peptic esophagitis  (ISO)
Phyllodes Tumor  (ISO)
pleomorphic xanthoastrocytoma  (ISO)
prostate cancer  (ISO)
Prostatic Neoplasms  (ISO)
pulmonary fibrosis  (ISO)
pulmonary hypertension  (ISO)
Pulmonary Hypertension, Hypoxia-Induced  (ISO)
pulmonary tuberculosis  (ISO)
rectal benign neoplasm  (ISO)
renal cell carcinoma  (ISO)
Right Ventricular Hypertrophy  (ISO)
schizophrenia  (ISO)
severe acute respiratory syndrome  (ISO)
Spinal Cord Injuries  (ISO)
squamous cell carcinoma  (ISO)
stomach cancer  (ISO)
Stomach Neoplasms  (ISO)
Tobacco Use Disorder  (ISO)
tongue squamous cell carcinoma  (ISO)
transitional cell carcinoma  (ISO)
type 1 diabetes mellitus  (ISO)
type 2 diabetes mellitus  (ISO)
urinary bladder cancer  (ISO)
Uterine Cervical Neoplasms  (ISO)
Vascular Remodeling  (ISO)
Ventricular Fibrillation  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
activation of MAPKK activity  (ISO)
astrocyte activation  (ISO)
cell morphogenesis  (ISO)
cell surface receptor signaling pathway  (ISO)
cell-cell adhesion  (ISO)
cellular response to amino acid stimulus  (ISO)
cellular response to cadmium ion  (ISO)
cellular response to dexamethasone stimulus  (ISO)
cellular response to drug  (ISO)
cellular response to epidermal growth factor stimulus  (ISO)
cellular response to estradiol stimulus  (ISO)
cellular response to growth factor stimulus  (ISO)
cellular response to mechanical stimulus  (ISO)
cellular response to reactive oxygen species  (ISO)
cerebral cortex cell migration  (ISO)
circadian rhythm  (ISO)
digestive tract morphogenesis  (ISO)
diterpenoid metabolic process  (ISO)
embryonic placenta development  (ISO)
epidermal growth factor receptor signaling pathway  (ISO)
epidermis development  (ISO)
eyelid development in camera-type eye  (ISO)
hair follicle development  (ISO)
hydrogen peroxide metabolic process  (ISO)
intracellular signal transduction  (ISO)
learning or memory  (ISO)
liver development  (ISO)
liver regeneration  (ISO)
lung development  (ISO)
magnesium ion homeostasis  (ISO)
midgut development  (ISO)
morphogenesis of an epithelial fold  (ISO)
negative regulation of apoptotic process  (ISO)
negative regulation of cardiocyte differentiation  (ISO)
negative regulation of mitotic cell cycle  (ISO)
negative regulation of protein catabolic process  (ISO)
neuron projection morphogenesis  (ISO)
ovulation cycle  (ISO)
peptidyl-tyrosine autophosphorylation  (ISO)
peptidyl-tyrosine phosphorylation  (ISO)
positive regulation of bone resorption  (ISO)
positive regulation of canonical Wnt signaling pathway  (ISO)
positive regulation of cell growth  (ISO)
positive regulation of cell migration  (ISO)
positive regulation of cell population proliferation  (ISO)
positive regulation of cyclin-dependent protein serine/threonine kinase activity  (ISO)
positive regulation of DNA repair  (ISO)
positive regulation of DNA replication  (ISO)
positive regulation of epithelial cell proliferation  (ISO)
positive regulation of ERK1 and ERK2 cascade  (ISO)
positive regulation of fibroblast proliferation  (ISO)
positive regulation of G1/S transition of mitotic cell cycle  (ISO)
positive regulation of glial cell proliferation  (ISO)
positive regulation of inflammatory response  (ISO)
positive regulation of MAP kinase activity  (ISO)
positive regulation of mucus secretion  (ISO)
positive regulation of NIK/NF-kappaB signaling  (ISO)
positive regulation of nitric oxide mediated signal transduction  (ISO)
positive regulation of peptidyl-serine phosphorylation  (ISO)
positive regulation of phosphorylation  (ISO)
positive regulation of production of miRNAs involved in gene silencing by miRNA  (ISO)
positive regulation of prolactin secretion  (ISO)
positive regulation of protein kinase B signaling  (ISO)
positive regulation of protein kinase C activity  (ISO)
positive regulation of protein localization to plasma membrane  (ISO)
positive regulation of protein phosphorylation  (ISO)
positive regulation of smooth muscle cell proliferation  (ISO)
positive regulation of superoxide anion generation  (ISO)
positive regulation of synaptic transmission, glutamatergic  (ISO)
positive regulation of transcription by RNA polymerase II  (ISO)
positive regulation of transcription, DNA-templated  (ISO)
positive regulation of vasoconstriction  (ISO)
protein autophosphorylation  (ISO)
receptor-mediated endocytosis  (ISO)
regulation of cell population proliferation  (ISO)
regulation of ERK1 and ERK2 cascade  (ISO)
regulation of JNK cascade  (ISO)
regulation of nitric-oxide synthase activity  (ISO)
regulation of peptidyl-tyrosine phosphorylation  (ISO)
regulation of phosphatidylinositol 3-kinase signaling  (ISO)
response to calcium ion  (ISO)
response to cobalamin  (ISO)
response to estradiol  (ISO)
response to hydroxyisoflavone  (ISO)
response to lipid  (ISO)
response to organic cyclic compound  (ISO)
response to osmotic stress  (ISO)
response to oxidative stress  (ISO)
response to UV-A  (ISO)
salivary gland morphogenesis  (ISO)
signal transduction  (ISO)
tongue development  (ISO)
translation  (ISO)
vasodilation  (ISO)
wound healing  (ISO)



Comparative Map Data
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0NW_004955456321,222 - 456,431 (-)NCBIChiLan1.0ChiLan1.0
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 Ensembl755,019,017 - 55,211,628 (+)EnsemblGRCh38hg38GRCh38
GRCh38755,019,017 - 55,211,628 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37755,086,710 - 55,279,321 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36755,054,219 - 55,242,525 (+)NCBINCBI36hg18NCBI36
Build 34754,860,933 - 55,012,947NCBI
Celera755,192,332 - 55,380,657 (+)NCBI
Cytogenetic Map7p11.2NCBI
HuRef754,924,934 - 55,112,834 (+)NCBIHuRef
CHM1_1755,089,165 - 55,277,398 (+)NCBICHM1_1
CRA_TCAGchr7v2755,092,507 - 55,280,831 (+)NCBI
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm391116,700,153 - 16,868,158 (+)NCBIGRCm39mm39
GRCm39 Ensembl1116,702,203 - 16,868,158 (+)Ensembl
GRCm381116,752,203 - 16,913,907 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1116,752,203 - 16,918,158 (+)EnsemblGRCm38mm10GRCm38
MGSCv371116,652,206 - 16,813,910 (+)NCBIGRCm37mm9NCBIm37
MGSCv361116,652,206 - 16,813,909 (+)NCBImm8
Celera1117,126,474 - 17,287,898 (+)NCBICelera
Cytogenetic Map11A2NCBI
cM Map119.41NCBI
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.21491,176,931 - 91,349,722 (+)NCBI
Rnor_6.0 Ensembl1499,919,485 - 100,098,796 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01499,919,485 - 100,104,136 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.014100,438,989 - 100,617,315 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41497,617,358 - 97,788,211 (+)NCBIRGSC3.4rn4RGSC3.4
Celera1490,225,928 - 90,392,779 (+)NCBICelera
RH 3.4 Map14 RGD
Cytogenetic Map14q22NCBI
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
PanPan1.1756,048,212 - 56,117,642 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl756,046,296 - 56,111,615 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0755,614,042 - 55,807,285 (+)NCBIMhudiblu_PPA_v0panPan3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.1185,983,669 - 6,044,092 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl185,982,770 - 6,042,631 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha185,693,578 - 5,890,886 (+)NCBI
ROS_Cfam_1.0185,890,289 - 6,087,722 (+)NCBI
UMICH_Zoey_3.1185,880,554 - 6,077,776 (+)NCBI
UNSW_CanFamBas_1.0185,854,700 - 6,051,915 (+)NCBI
UU_Cfam_GSD_1.0185,960,845 - 6,158,207 (+)NCBI
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
HiC_Itri_2NW_024405118109,328,850 - 109,524,551 (+)NCBI
SpeTri2.0NW_004936678365,005 - 560,546 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl9139,300,022 - 139,478,882 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.19139,302,410 - 139,474,632 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.1213,664,622 - 3,853,492 (-)NCBI
ChlSab1.1 Ensembl213,666,339 - 3,853,239 (-)Ensembl
Vero_WHO_p1.0NW_02366606218,644,141 - 18,836,149 (+)NCBI
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
HetGla 1.0NW_004624740584,133 - 713,205 (-)NCBI



Reference Sequences
RefSeq Acc Id: XM_005396877   ⟹   XP_005396934
RefSeq Status:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_004955456321,222 - 456,431 (-)NCBI
Protein Sequences
Protein RefSeqs XP_005396934 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_005396934   ⟸   XM_005396877
- Sequence:

Additional Information

Database Acc Id Source(s)