EGFR (epidermal growth factor receptor) - Rat Genome Database

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Gene: EGFR (epidermal growth factor receptor) Pan paniscus
Analyze
Symbol: EGFR
Name: epidermal growth factor receptor
RGD ID: 11704382
Description: ENCODES a protein that exhibits actin filament binding (ortholog); calmodulin binding (ortholog); chromatin binding (ortholog); INVOLVED IN astrocyte activation (ortholog); cell morphogenesis (ortholog); cell surface receptor signaling pathway (ortholog); PARTICIPATES IN altered epidermal growth factor/neuregulin signaling pathway; cetuximab pharmacodynamics pathway; E-cadherin signaling pathway; ASSOCIATED WITH acute kidney failure (ortholog); Acute Lung Injury (ortholog); adenocarcinoma (ortholog); FOUND IN apical plasma membrane (ortholog); basolateral plasma membrane (ortholog); cell junction (ortholog)
Type: protein-coding
RefSeq Status: MODEL
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1756,048,212 - 56,117,642 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl756,046,296 - 56,111,615 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0755,614,042 - 55,807,285 (+)NCBIMhudiblu_PPA_v0panPan3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
acute kidney failure  (ISO)
Acute Lung Injury  (ISO)
adenocarcinoma  (ISO)
adrenocortical carcinoma  (ISO)
Alcoholic Liver Diseases  (ISO)
Alzheimer's disease  (ISO)
Animal Mammary Neoplasms  (ISO)
aortic valve stenosis  (ISO)
arteriovenous malformations of the brain  (ISO)
asthma  (ISO)
autistic disorder  (ISO)
autosomal recessive polycystic kidney disease  (ISO)
Bile Duct Neoplasms  (ISO)
Brain Neoplasms  (ISO)
breast cancer  (ISO)
breast carcinoma  (ISO)
Breast Neoplasms  (ISO)
bronchiolo-alveolar adenocarcinoma  (ISO)
carcinoma  (ISO)
Cardiomegaly  (ISO)
Chloracne  (ISO)
cholangiocarcinoma  (ISO)
chronic obstructive pulmonary disease  (ISO)
Colonic Neoplasms  (ISO)
colorectal cancer  (ISO)
Colorectal Neoplasms  (ISO)
Cowden syndrome  (ISO)
Craniofacial Abnormalities  (ISO)
dementia  (ISO)
dermatitis  (ISO)
diabetic retinopathy  (ISO)
dilated cardiomyopathy  (ISO)
Disease Progression  (ISO)
Endometrioid Carcinomas  (ISO)
endometriosis  (ISO)
esophageal carcinoma  (ISO)
Esophageal Neoplasms  (ISO)
esophagus squamous cell carcinoma  (ISO)
Experimental Arthritis  (ISO)
Experimental Diabetes Mellitus  (ISO)
familial adenomatous polyposis  (ISO)
Gallbladder Neoplasms  (ISO)
glioblastoma  (ISO)
Head and Neck Neoplasms  (ISO)
head and neck squamous cell carcinoma  (ISO)
Helicobacter Infections  (ISO)
hepatocellular carcinoma  (ISO)
hereditary breast ovarian cancer syndrome  (ISO)
Hereditary Neoplastic Syndromes  (ISO)
high grade glioma  (ISO)
Huntington's disease  (ISO)
Hyperplasia  (ISO)
hypertension  (ISO)
Immediate Hypersensitivity  (ISO)
Inflammation  (ISO)
Insulin Resistance  (ISO)
Laryngeal Neoplasms  (ISO)
laryngeal squamous cell carcinoma  (ISO)
Left Ventricular Hypertrophy  (ISO)
leiomyoma  (ISO)
liver cirrhosis  (ISO)
lung adenocarcinoma  (ISO)
lung cancer  (ISO)
lung carcinoma  (ISO)
lung disease  (ISO)
Lung Neoplasms  (ISO)
lung non-small cell carcinoma  (ISO)
lung small cell carcinoma  (ISO)
lung squamous cell carcinoma  (ISO)
Lymphatic Metastasis  (ISO)
malignant mesothelioma  (ISO)
Mammary Neoplasms, Experimental  (ISO)
median neuropathy  (ISO)
Mesothelioma  (ISO)
Nasopharyngeal Neoplasms  (ISO)
Neonatal Inflammatory Skin and Bowel Disease 2  (ISO)
Neoplasm Invasiveness  (ISO)
Neoplasm Metastasis  (ISO)
Neoplasm Recurrence, Local  (ISO)
obesity  (ISO)
oral squamous cell carcinoma  (ISO)
osteosarcoma  (ISO)
Ovarian Neoplasms  (ISO)
pancreatic cancer  (ISO)
papilloma  (ISO)
papillomavirus infectious disease  (ISO)
Parkinson's disease  (ISO)
Parkinsonism  (ISO)
peptic esophagitis  (ISO)
Phyllodes Tumor  (ISO)
pleomorphic xanthoastrocytoma  (ISO)
prostate cancer  (ISO)
Prostatic Neoplasms  (ISO)
pulmonary fibrosis  (ISO)
pulmonary hypertension  (ISO)
Pulmonary Hypertension, Hypoxia-Induced  (ISO)
pulmonary tuberculosis  (ISO)
rectal benign neoplasm  (ISO)
renal cell carcinoma  (ISO)
Right Ventricular Hypertrophy  (ISO)
schizophrenia  (ISO)
severe acute respiratory syndrome  (ISO)
Spinal Cord Injuries  (ISO)
squamous cell carcinoma  (ISO)
stomach cancer  (ISO)
Stomach Neoplasms  (ISO)
Tobacco Use Disorder  (ISO)
tongue squamous cell carcinoma  (ISO)
transitional cell carcinoma  (ISO)
type 1 diabetes mellitus  (ISO)
type 2 diabetes mellitus  (ISO)
urinary bladder cancer  (ISO)
Uterine Cervical Neoplasms  (ISO)
Vascular Remodeling  (ISO)
Ventricular Fibrillation  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
astrocyte activation  (ISO)
cell morphogenesis  (ISO)
cell surface receptor signaling pathway  (ISO)
cell-cell adhesion  (ISO)
cellular response to amino acid stimulus  (ISO)
cellular response to cadmium ion  (ISO)
cellular response to dexamethasone stimulus  (ISO)
cellular response to drug  (ISO)
cellular response to epidermal growth factor stimulus  (ISO)
cellular response to estradiol stimulus  (ISO)
cellular response to growth factor stimulus  (ISO)
cellular response to mechanical stimulus  (ISO)
cellular response to reactive oxygen species  (ISO)
cerebral cortex cell migration  (ISO)
circadian rhythm  (ISO)
digestive tract morphogenesis  (ISO)
diterpenoid metabolic process  (ISO)
embryonic placenta development  (ISO)
epidermal growth factor receptor signaling pathway  (ISO)
epidermis development  (ISO)
eyelid development in camera-type eye  (ISO)
hair follicle development  (ISO)
hydrogen peroxide metabolic process  (ISO)
intracellular signal transduction  (ISO)
learning or memory  (ISO)
liver development  (ISO)
liver regeneration  (ISO)
lung development  (ISO)
magnesium ion homeostasis  (ISO)
midgut development  (ISO)
morphogenesis of an epithelial fold  (ISO)
negative regulation of apoptotic process  (ISO)
negative regulation of cardiocyte differentiation  (ISO)
negative regulation of mitotic cell cycle  (ISO)
negative regulation of protein catabolic process  (ISO)
neuron projection morphogenesis  (ISO)
ovulation cycle  (ISO)
peptidyl-tyrosine autophosphorylation  (ISO)
peptidyl-tyrosine phosphorylation  (ISO)
positive regulation of bone resorption  (ISO)
positive regulation of canonical Wnt signaling pathway  (ISO)
positive regulation of cell growth  (ISO)
positive regulation of cell migration  (ISO)
positive regulation of cell population proliferation  (ISO)
positive regulation of cyclin-dependent protein serine/threonine kinase activity  (ISO)
positive regulation of DNA repair  (ISO)
positive regulation of DNA replication  (ISO)
positive regulation of epithelial cell proliferation  (ISO)
positive regulation of ERK1 and ERK2 cascade  (ISO)
positive regulation of fibroblast proliferation  (ISO)
positive regulation of G1/S transition of mitotic cell cycle  (ISO)
positive regulation of glial cell proliferation  (ISO)
positive regulation of inflammatory response  (ISO)
positive regulation of MAP kinase activity  (ISO)
positive regulation of MAPK cascade  (ISO)
positive regulation of mucus secretion  (ISO)
positive regulation of NIK/NF-kappaB signaling  (ISO)
positive regulation of nitric oxide mediated signal transduction  (ISO)
positive regulation of peptidyl-serine phosphorylation  (ISO)
positive regulation of phosphorylation  (ISO)
positive regulation of production of miRNAs involved in gene silencing by miRNA  (ISO)
positive regulation of prolactin secretion  (ISO)
positive regulation of protein kinase B signaling  (ISO)
positive regulation of protein kinase C activity  (ISO)
positive regulation of protein localization to plasma membrane  (ISO)
positive regulation of protein phosphorylation  (ISO)
positive regulation of smooth muscle cell proliferation  (ISO)
positive regulation of superoxide anion generation  (ISO)
positive regulation of synaptic transmission, glutamatergic  (ISO)
positive regulation of transcription by RNA polymerase II  (ISO)
positive regulation of transcription, DNA-templated  (ISO)
positive regulation of vasoconstriction  (ISO)
protein autophosphorylation  (ISO)
receptor-mediated endocytosis  (ISO)
regulation of cell population proliferation  (ISO)
regulation of ERK1 and ERK2 cascade  (ISO)
regulation of JNK cascade  (ISO)
regulation of nitric-oxide synthase activity  (ISO)
regulation of peptidyl-tyrosine phosphorylation  (ISO)
regulation of phosphatidylinositol 3-kinase signaling  (ISO)
response to calcium ion  (ISO)
response to cobalamin  (ISO)
response to estradiol  (ISO)
response to hydroxyisoflavone  (ISO)
response to lipid  (ISO)
response to organic cyclic compound  (ISO)
response to osmotic stress  (ISO)
response to oxidative stress  (ISO)
response to UV-A  (ISO)
salivary gland morphogenesis  (ISO)
signal transduction  (ISO)
tongue development  (ISO)
translation  (ISO)
vasodilation  (ISO)
wound healing  (ISO)

References

Genomics

Comparative Map Data
EGFR
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1756,048,212 - 56,117,642 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl756,046,296 - 56,111,615 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0755,614,042 - 55,807,285 (+)NCBIMhudiblu_PPA_v0panPan3
EGFR
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl755,019,017 - 55,211,628 (+)EnsemblGRCh38hg38GRCh38
GRCh38755,019,017 - 55,211,628 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37755,086,710 - 55,279,321 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36755,054,219 - 55,242,525 (+)NCBINCBI36hg18NCBI36
Build 34754,860,933 - 55,012,947NCBI
Celera755,192,332 - 55,380,657 (+)NCBI
Cytogenetic Map7p11.2NCBI
HuRef754,924,934 - 55,112,834 (+)NCBIHuRef
CHM1_1755,089,165 - 55,277,398 (+)NCBICHM1_1
CRA_TCAGchr7v2755,092,507 - 55,280,831 (+)NCBI
Egfr
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391116,700,153 - 16,868,158 (+)NCBIGRCm39mm39
GRCm39 Ensembl1116,702,203 - 16,868,158 (+)Ensembl
GRCm381116,752,203 - 16,913,907 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1116,752,203 - 16,918,158 (+)EnsemblGRCm38mm10GRCm38
MGSCv371116,652,206 - 16,813,910 (+)NCBIGRCm37mm9NCBIm37
MGSCv361116,652,206 - 16,813,909 (+)NCBImm8
Celera1117,126,474 - 17,287,898 (+)NCBICelera
Cytogenetic Map11A2NCBI
cM Map119.41NCBI
Egfr
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21491,176,931 - 91,349,722 (+)NCBI
Rnor_6.0 Ensembl1499,919,485 - 100,098,796 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01499,919,485 - 100,104,136 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.014100,438,989 - 100,617,315 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41497,617,358 - 97,788,211 (+)NCBIRGSC3.4rn4RGSC3.4
Celera1490,225,928 - 90,392,779 (+)NCBICelera
RH 3.4 Map14 RGD
Cytogenetic Map14q22NCBI
Egfr
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_004955456321,222 - 456,431 (-)NCBIChiLan1.0ChiLan1.0
EGFR
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1185,983,669 - 6,044,092 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl185,982,770 - 6,042,631 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha185,693,578 - 5,890,886 (+)NCBI
ROS_Cfam_1.0185,890,289 - 6,087,722 (+)NCBI
UMICH_Zoey_3.1185,880,554 - 6,077,776 (+)NCBI
UNSW_CanFamBas_1.0185,854,700 - 6,051,915 (+)NCBI
UU_Cfam_GSD_1.0185,960,845 - 6,158,207 (+)NCBI
Egfr
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118109,328,850 - 109,524,551 (+)NCBI
SpeTri2.0NW_004936678365,005 - 560,546 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
EGFR
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl9139,300,022 - 139,478,882 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.19139,302,410 - 139,474,632 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
EGFR
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1213,664,622 - 3,853,492 (-)NCBI
ChlSab1.1 Ensembl213,666,339 - 3,853,239 (-)Ensembl
Vero_WHO_p1.0NW_02366606218,644,141 - 18,836,149 (+)NCBI
Egfr
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_004624740584,133 - 713,205 (-)NCBI


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSPPAT00000066105   ⟹   ENSPPAP00000043170
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl756,046,296 - 56,111,615 (+)Ensembl
RefSeq Acc Id: ENSPPAT00000066106   ⟹   ENSPPAP00000043171
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl756,046,296 - 56,111,615 (+)Ensembl
RefSeq Acc Id: ENSPPAT00000066107   ⟹   ENSPPAP00000043172
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl756,047,943 - 56,111,615 (+)Ensembl
RefSeq Acc Id: ENSPPAT00000066108   ⟹   ENSPPAP00000043173
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl756,048,156 - 56,109,018 (+)Ensembl
RefSeq Acc Id: ENSPPAT00000066109   ⟹   ENSPPAP00000043174
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl756,048,208 - 56,111,615 (+)Ensembl
RefSeq Acc Id: ENSPPAT00000066110   ⟹   ENSPPAP00000043175
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl756,048,210 - 56,076,798 (+)Ensembl
RefSeq Acc Id: ENSPPAT00000066111   ⟹   ENSPPAP00000043176
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl756,048,210 - 56,074,774 (+)Ensembl
RefSeq Acc Id: XM_034964127   ⟹   XP_034820018
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
Mhudiblu_PPA_v0755,614,042 - 55,807,285 (+)NCBI
RefSeq Acc Id: XM_034964128   ⟹   XP_034820019
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
Mhudiblu_PPA_v0755,614,042 - 55,766,933 (+)NCBI
Protein Sequences
Protein RefSeqs XP_034820018 (Get FASTA)   NCBI Sequence Viewer  
  XP_034820019 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_034820018   ⟸   XM_034964127
- Peptide Label: isoform X1
RefSeq Acc Id: XP_034820019   ⟸   XM_034964128
- Peptide Label: isoform X2
RefSeq Acc Id: ENSPPAP00000043176   ⟸   ENSPPAT00000066111
RefSeq Acc Id: ENSPPAP00000043175   ⟸   ENSPPAT00000066110
RefSeq Acc Id: ENSPPAP00000043174   ⟸   ENSPPAT00000066109
RefSeq Acc Id: ENSPPAP00000043173   ⟸   ENSPPAT00000066108
RefSeq Acc Id: ENSPPAP00000043172   ⟸   ENSPPAT00000066107
RefSeq Acc Id: ENSPPAP00000043171   ⟸   ENSPPAT00000066106
RefSeq Acc Id: ENSPPAP00000043170   ⟸   ENSPPAT00000066105

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000044119 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSPPAP00000043170 UniProtKB/TrEMBL
  ENSPPAP00000043171 UniProtKB/TrEMBL
  ENSPPAP00000043172 UniProtKB/TrEMBL
  ENSPPAP00000043173 UniProtKB/TrEMBL
  ENSPPAP00000043174 UniProtKB/TrEMBL
  ENSPPAP00000043175 UniProtKB/TrEMBL
  ENSPPAP00000043176 UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000066105 UniProtKB/TrEMBL
  ENSPPAT00000066106 UniProtKB/TrEMBL
  ENSPPAT00000066107 UniProtKB/TrEMBL
  ENSPPAT00000066108 UniProtKB/TrEMBL
  ENSPPAT00000066109 UniProtKB/TrEMBL
  ENSPPAT00000066110 UniProtKB/TrEMBL
  ENSPPAT00000066111 UniProtKB/TrEMBL
Gene3D-CATH 3.80.20.20 UniProtKB/TrEMBL
InterPro Furin-like_Cys-rich_dom UniProtKB/TrEMBL
  Furin_repeat UniProtKB/TrEMBL
  GF_recep_IV UniProtKB/TrEMBL
  Growth_fac_rcpt_cys_sf UniProtKB/TrEMBL
  Kinase-like_dom_sf UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/TrEMBL
  Rcpt_L-dom UniProtKB/TrEMBL
  Rcpt_L-dom_sf UniProtKB/TrEMBL
  Ser-Thr/Tyr_kinase_cat_dom UniProtKB/TrEMBL
  Tyr_kinase_AS UniProtKB/TrEMBL
  Tyr_kinase_cat_dom UniProtKB/TrEMBL
  Tyr_kinase_EGF/ERB/XmrK_rcpt UniProtKB/TrEMBL
KEGG Report pps:100974885 UniProtKB/TrEMBL
NCBI Gene EGFR ENTREZGENE
Pfam Furin-like UniProtKB/TrEMBL
  GF_recep_IV UniProtKB/TrEMBL
  Pkinase_Tyr UniProtKB/TrEMBL
  Recep_L_domain UniProtKB/TrEMBL
PIRSF TyrPK_EGF-R UniProtKB/TrEMBL
PRINTS TYRKINASE UniProtKB/TrEMBL
PROSITE PROTEIN_KINASE_ATP UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
  PROTEIN_KINASE_TYR UniProtKB/TrEMBL
SMART SM00261 UniProtKB/TrEMBL
  TyrKc UniProtKB/TrEMBL
Superfamily-SCOP SSF56112 UniProtKB/TrEMBL
  SSF57184 UniProtKB/TrEMBL
UniProt A0A2R9CME7_PANPA UniProtKB/TrEMBL
  A0A2R9CMF2_PANPA UniProtKB/TrEMBL
  A0A2R9CMH6_PANPA UniProtKB/TrEMBL
  A0A2R9CMH7_PANPA UniProtKB/TrEMBL
  A0A2R9CMI1_PANPA UniProtKB/TrEMBL
  A0A2R9CP96_PANPA UniProtKB/TrEMBL
  A0A2R9CTL6_PANPA UniProtKB/TrEMBL