Eps8 (EGFR pathway substrate 8, signaling adaptor) - Rat Genome Database

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Gene: Eps8 (EGFR pathway substrate 8, signaling adaptor) Heterocephalus glaber
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Symbol: Eps8
Name: EGFR pathway substrate 8, signaling adaptor (Ensembl:epidermal growth factor receptor pathway substrate 8)
RGD ID: 18935934
Description: ENCODES a protein that exhibits small GTPase binding (ortholog); INVOLVED IN actin crosslink formation (ortholog); actin cytoskeleton organization (ortholog); actin filament bundle assembly (ortholog); PARTICIPATES IN platelet-derived growth factor signaling pathway; ASSOCIATED WITH autosomal dominant intellectual developmental disorder 6 (ortholog); autosomal recessive nonsyndromic deafness (ortholog); autosomal recessive nonsyndromic deafness 102 (ortholog); FOUND IN brush border (ortholog); cell cortex (ortholog); glutamatergic synapse (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: epidermal growth factor receptor kinase substrate 8; epidermal growth factor receptor pathway substrate 8
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475222,295,413 - 22,426,717 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475222,250,988 - 22,424,957 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:30032202  


Genomics

Comparative Map Data
Eps8
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475222,295,413 - 22,426,717 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475222,250,988 - 22,424,957 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2
EPS8
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381215,620,134 - 15,789,388 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1215,620,134 - 15,882,329 (-)EnsemblGRCh38hg38GRCh38
GRCh371215,773,068 - 15,942,322 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361215,664,342 - 15,833,601 (-)NCBINCBI36Build 36hg18NCBI36
Build 341215,664,342 - 15,833,601NCBI
Celera1220,917,962 - 21,087,395 (-)NCBICelera
Cytogenetic Map12p12.3NCBI
HuRef1215,542,405 - 15,711,684 (-)NCBIHuRef
CHM1_11215,739,030 - 15,908,465 (-)NCBICHM1_1
T2T-CHM13v2.01215,497,359 - 15,666,619 (-)NCBIT2T-CHM13v2.0
Eps8
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm396137,454,242 - 137,626,262 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl6137,454,243 - 137,631,874 (-)EnsemblGRCm39 Ensembl
GRCm386137,477,245 - 137,649,397 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl6137,477,245 - 137,654,876 (-)EnsemblGRCm38mm10GRCm38
MGSCv376137,425,766 - 137,597,641 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv366137,441,441 - 137,613,316 (-)NCBIMGSCv36mm8
MGSCv366137,872,768 - 137,987,281 (-)NCBIMGSCv36mm8
Celera6140,541,302 - 140,657,063 (-)NCBICelera
Cytogenetic Map6G1NCBI
cM Map666.78NCBI
Eps8
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84172,119,497 - 172,291,670 (-)NCBIGRCr8
mRatBN7.24170,388,378 - 170,486,873 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4170,388,378 - 170,486,873 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4176,680,716 - 176,779,656 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04172,465,042 - 172,563,994 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04171,085,423 - 171,184,375 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.04171,475,155 - 171,645,620 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4171,475,567 - 171,591,882 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04235,732,277 - 235,903,027 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44174,601,291 - 174,672,247 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.14174,848,196 - 174,917,371 (-)NCBI
Celera4158,967,950 - 159,084,908 (-)NCBICelera
Cytogenetic Map4q44NCBI
Eps8
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541312,266,371 - 12,386,088 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541312,267,701 - 12,386,088 (-)NCBIChiLan1.0ChiLan1.0
EPS8
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21021,063,405 - 21,262,151 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11221,060,141 - 21,255,181 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01215,617,536 - 15,788,537 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11216,013,270 - 16,184,203 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1216,013,276 - 16,076,117 (-)Ensemblpanpan1.1panPan2
EPS8
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12730,893,884 - 31,070,401 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2730,893,713 - 31,069,770 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2715,378,134 - 15,554,665 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02731,213,204 - 31,391,094 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2731,213,046 - 31,391,090 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12731,212,841 - 31,279,922 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02731,058,974 - 31,235,537 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02715,100,205 - 15,276,688 (-)NCBIUU_Cfam_GSD_1.0
Eps8
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494592,057,948 - 92,223,689 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365871,785,303 - 1,951,332 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365871,785,721 - 1,951,474 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
EPS8
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl556,817,606 - 57,005,113 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1556,817,445 - 57,005,117 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2560,303,025 - 60,409,561 (-)NCBISscrofa10.2Sscrofa10.2susScr3
EPS8
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11115,522,761 - 15,691,343 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1115,522,616 - 15,691,133 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366606919,609,645 - 19,778,199 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSHGLT00000019829   ⟹   ENSHGLP00000019633
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_00462475222,295,413 - 22,426,717 (+)Ensembl
Ensembl Acc Id: ENSHGLT00000019830   ⟹   ENSHGLP00000019634
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_00462475222,319,442 - 22,426,717 (+)Ensembl
RefSeq Acc Id: XM_004845819   ⟹   XP_004845876
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462475222,319,996 - 22,424,957 (+)NCBI
RefSeq Acc Id: XM_004845820   ⟹   XP_004845877
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462475222,250,988 - 22,424,957 (+)NCBI
Protein Sequences
Protein RefSeqs XP_004845876 (Get FASTA)   NCBI Sequence Viewer  
  XP_004845877 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSHGLP00000019633
  ENSHGLP00000019634
  ENSHGLP00100040059
GenBank Protein JAO01222 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: XP_004845877   ⟸   XM_004845820
- UniProtKB: A0A0N8EU69 (UniProtKB/TrEMBL),   G5BV42 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_004845876   ⟸   XM_004845819
- UniProtKB: A0A0N8EU69 (UniProtKB/TrEMBL),   G5BV42 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSHGLP00000019634   ⟸   ENSHGLT00000019830
Ensembl Acc Id: ENSHGLP00000019633   ⟸   ENSHGLT00000019829


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSHGLG00000014063 Ensembl, ENTREZGENE
  ENSHGLG00100001714 UniProtKB/TrEMBL
Ensembl Transcript ENSHGLT00000019829 ENTREZGENE
  ENSHGLT00000019830 ENTREZGENE
  ENSHGLT00100072154 UniProtKB/TrEMBL
Gene3D-CATH 1.10.150.50 UniProtKB/TrEMBL
  2.30.29.30 UniProtKB/TrEMBL
  SH3 Domains UniProtKB/TrEMBL
InterPro EPS8-like UniProtKB/TrEMBL
  EPS8_PTB UniProtKB/TrEMBL
  Eps8_SH3 UniProtKB/TrEMBL
  PH-like_dom_sf UniProtKB/TrEMBL
  PTB UniProtKB/TrEMBL
  PTB/PI_dom UniProtKB/TrEMBL
  SAM/pointed_sf UniProtKB/TrEMBL
  SAM_3 UniProtKB/TrEMBL
  SH3-like_dom_sf UniProtKB/TrEMBL
  SH3_domain UniProtKB/TrEMBL
KEGG Report hgl:101715552 UniProtKB/TrEMBL
NCBI Gene Eps8 ENTREZGENE
PANTHER PTHR12287 UniProtKB/TrEMBL
  PTHR12287:SF21 UniProtKB/TrEMBL
Pfam EPS8_2nd UniProtKB/TrEMBL
  PTB UniProtKB/TrEMBL
  SAM_3 UniProtKB/TrEMBL
  SH3_1 UniProtKB/TrEMBL
PROSITE SH3 UniProtKB/TrEMBL
SMART PTB UniProtKB/TrEMBL
  SH3 UniProtKB/TrEMBL
Superfamily-SCOP PH domain-like UniProtKB/TrEMBL
  SSF50044 UniProtKB/TrEMBL
UniProt A0A0N8EU69 ENTREZGENE, UniProtKB/TrEMBL
  G5BV42 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2023-11-15 Eps8  EGFR pathway substrate 8, signaling adaptor  Eps8  epidermal growth factor receptor pathway substrate 8  Symbol and/or name change 5135510 APPROVED