Tie1 (tyrosine kinase with immunoglobulin like and EGF like domains 1) - Rat Genome Database

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Gene: Tie1 (tyrosine kinase with immunoglobulin like and EGF like domains 1) Chinchilla lanigera
Analyze
Symbol: Tie1
Name: tyrosine kinase with immunoglobulin like and EGF like domains 1
RGD ID: 8922352
Description: INVOLVED IN aortic valve morphogenesis (ortholog); blood vessel development (ortholog); branching involved in lymph vessel morphogenesis (ortholog); ASSOCIATED WITH Charcot-Marie-Tooth disease dominant intermediate C (ortholog); genetic disease (ortholog); Lymphatic Malformation 11 (ortholog); FOUND IN plasma membrane (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: tyrosine kinase with immunoglobulin-like and EGF-like domains 1; tyrosine-protein kinase receptor Tie-1
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: ChiLan1.0 - Chinchilla ChiLan1.0 Assembly
Position:
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555372,894,914 - 2,914,284 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555372,894,913 - 2,914,284 (+)NCBIChiLan1.0ChiLan1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Transitive Annotation Pipeline Automated assignment of GO, PW and RDO ISO annotations across species
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Tie1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555372,894,914 - 2,914,284 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555372,894,913 - 2,914,284 (+)NCBIChiLan1.0ChiLan1.0
TIE1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38143,300,982 - 43,323,108 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl143,300,982 - 43,323,108 (+)EnsemblGRCh38hg38GRCh38
GRCh37143,766,653 - 43,788,779 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36143,539,251 - 43,561,366 (+)NCBINCBI36Build 36hg18NCBI36
Build 34143,435,756 - 43,457,871NCBI
Celera142,048,758 - 42,070,929 (+)NCBICelera
Cytogenetic Map1p34.2NCBI
HuRef141,886,193 - 41,908,461 (+)NCBIHuRef
CHM1_1143,883,045 - 43,905,255 (+)NCBICHM1_1
T2T-CHM13v2.0143,171,478 - 43,193,657 (+)NCBIT2T-CHM13v2.0
Tie1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394118,328,388 - 118,347,046 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4118,328,388 - 118,347,258 (-)EnsemblGRCm39 Ensembl
GRCm384118,471,191 - 118,489,849 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4118,471,191 - 118,490,061 (-)EnsemblGRCm38mm10GRCm38
MGSCv374118,143,796 - 118,162,454 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv364117,969,123 - 117,987,993 (-)NCBIMGSCv36mm8
Celera4117,196,542 - 117,215,172 (-)NCBICelera
Cytogenetic Map4D2.1NCBI
cM Map454.67NCBI
Tie1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85137,285,408 - 137,305,047 (-)NCBIGRCr8
mRatBN7.25132,000,013 - 132,019,658 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5132,000,015 - 132,019,592 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5134,707,265 - 134,726,814 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05136,461,906 - 136,481,457 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05136,484,304 - 136,503,857 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.05137,294,544 - 137,321,116 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5137,294,544 - 137,321,121 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05141,084,008 - 141,111,659 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45138,945,238 - 138,964,631 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15138,956,127 - 138,959,186 (-)NCBI
Celera5130,545,484 - 130,565,067 (-)NCBICelera
Cytogenetic Map5q36NCBI
TIE1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21183,486,976 - 183,509,122 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11182,628,363 - 182,650,510 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0142,602,333 - 42,624,471 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1143,979,838 - 44,002,167 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl143,979,838 - 44,002,167 (+)Ensemblpanpan1.1panPan2
TIE1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11516,838,267 - 16,857,004 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1516,838,582 - 16,856,946 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1516,966,265 - 16,985,016 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01517,005,994 - 17,024,782 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1517,005,994 - 17,024,743 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11516,798,449 - 16,817,196 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01516,867,446 - 16,886,176 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01516,941,001 - 16,959,771 (-)NCBIUU_Cfam_GSD_1.0
Tie1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505858,884,532 - 58,904,470 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647424,709,424 - 24,729,245 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647424,709,424 - 24,729,246 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TIE1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl6167,919,668 - 167,940,870 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.16167,919,662 - 167,947,253 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.26155,288,305 - 155,322,123 (+)NCBISscrofa10.2Sscrofa10.2susScr3
TIE1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12089,483,089 - 89,505,716 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2089,483,039 - 89,505,246 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603327,415,677 - 27,438,411 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tie1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248922,626,875 - 2,645,841 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248922,626,999 - 2,645,841 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSCLAT00000006277   ⟹   ENSCLAP00000006174
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_0049555372,894,914 - 2,914,284 (+)Ensembl
RefSeq Acc Id: XM_005410646   ⟹   XP_005410703
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049555372,894,913 - 2,914,284 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005410647   ⟹   XP_005410704
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049555372,894,914 - 2,914,284 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_005410703 (Get FASTA)   NCBI Sequence Viewer  
  XP_005410704 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCLAP00000006174
  ENSCLAP00000006174.1
Reference Protein Sequences
RefSeq Acc Id: XP_005410704   ⟸   XM_005410647
- Peptide Label: isoform X1
- UniProtKB: A0A8C2V015 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005410703   ⟸   XM_005410646
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: ENSCLAP00000006174   ⟸   ENSCLAT00000006277
Protein Domains
EGF-like   Fibronectin type-III   Protein kinase


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCLAG00000004371 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCLAT00000006277 ENTREZGENE
  ENSCLAT00000006277.1 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.10 UniProtKB/TrEMBL
  Tie2 ligand-binding domain superfamily UniProtKB/TrEMBL
  Transferase(Phosphotransferase) domain 1 UniProtKB/TrEMBL
InterPro EGF-like_dom UniProtKB/TrEMBL
  FN3_dom UniProtKB/TrEMBL
  FN3_sf UniProtKB/TrEMBL
  Ig-like_dom_sf UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/TrEMBL
  Ig_sub UniProtKB/TrEMBL
  Immunoglobulin UniProtKB/TrEMBL
  Kinase-like_dom_sf UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/TrEMBL
  Ser-Thr/Tyr_kinase_cat_dom UniProtKB/TrEMBL
  Tyr_kinase_AS UniProtKB/TrEMBL
  Tyr_kinase_cat_dom UniProtKB/TrEMBL
NCBI Gene Tie1 ENTREZGENE
PANTHER TYROSINE-PROTEIN KINASE RECEPTOR UniProtKB/TrEMBL
  TYROSINE-PROTEIN KINASE RECEPTOR TIE-1 UniProtKB/TrEMBL
Pfam fn3 UniProtKB/TrEMBL
  PF00047 UniProtKB/TrEMBL
  PK_Tyr_Ser-Thr UniProtKB/TrEMBL
PRINTS TYRKINASE UniProtKB/TrEMBL
PROSITE EGF_1 UniProtKB/TrEMBL
  EGF_2 UniProtKB/TrEMBL
  EGF_3 UniProtKB/TrEMBL
  FN3 UniProtKB/TrEMBL
  PROTEIN_KINASE_ATP UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
  PROTEIN_KINASE_TYR UniProtKB/TrEMBL
SMART EGF UniProtKB/TrEMBL
  FN3 UniProtKB/TrEMBL
  SM00409 UniProtKB/TrEMBL
  TyrKc UniProtKB/TrEMBL
Superfamily-SCOP SSF48726 UniProtKB/TrEMBL
  SSF49265 UniProtKB/TrEMBL
  SSF56112 UniProtKB/TrEMBL
UniProt A0A8C2V015 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-08-03 Tie1  tyrosine kinase with immunoglobulin like and EGF like domains 1    tyrosine kinase with immunoglobulin-like and EGF-like domains 1  Symbol and/or name change 5135510 APPROVED