MEGF11 (multiple EGF like domains 11) - Rat Genome Database

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Gene: MEGF11 (multiple EGF like domains 11) Homo sapiens
Analyze
Symbol: MEGF11
Name: multiple EGF like domains 11
RGD ID: 1603600
HGNC Page HGNC:29635
Description: Predicted to enable scavenger receptor activity. Predicted to be involved in homotypic cell-cell adhesion and retina layer formation. Predicted to be located in basolateral plasma membrane.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: DKFZp434L121; KIAA1781; multiple EGF-like domains protein 11; multiple EGF-like-domains 11; multiple epidermal growth factor-like domains protein 11
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381565,895,299 - 66,253,750 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1565,895,079 - 66,253,756 (-)EnsemblGRCh38hg38GRCh38
GRCh371566,187,637 - 66,546,088 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361563,974,693 - 64,333,129 (-)NCBINCBI36Build 36hg18NCBI36
Celera1543,065,556 - 43,436,170 (-)NCBICelera
Cytogenetic Map15q22.31NCBI
HuRef1543,012,367 - 43,382,504 (-)NCBIHuRef
CHM1_11566,305,506 - 66,664,221 (-)NCBICHM1_1
T2T-CHM13v2.01563,704,723 - 64,075,393 (-)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:11347906   PMID:12477932   PMID:12975309   PMID:14702039   PMID:16713569   PMID:17498693   PMID:19851296   PMID:20198315   PMID:21653829   PMID:22199357   PMID:24999758   PMID:32296183  
PMID:35398017   PMID:37120575  


Genomics

Comparative Map Data
MEGF11
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381565,895,299 - 66,253,750 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1565,895,079 - 66,253,756 (-)EnsemblGRCh38hg38GRCh38
GRCh371566,187,637 - 66,546,088 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361563,974,693 - 64,333,129 (-)NCBINCBI36Build 36hg18NCBI36
Celera1543,065,556 - 43,436,170 (-)NCBICelera
Cytogenetic Map15q22.31NCBI
HuRef1543,012,367 - 43,382,504 (-)NCBIHuRef
CHM1_11566,305,506 - 66,664,221 (-)NCBICHM1_1
T2T-CHM13v2.01563,704,723 - 64,075,393 (-)NCBIT2T-CHM13v2.0
Megf11
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39964,291,556 - 64,618,584 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl964,292,908 - 64,616,487 (+)EnsemblGRCm39 Ensembl
GRCm38964,385,617 - 64,714,179 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl964,385,626 - 64,709,205 (+)EnsemblGRCm38mm10GRCm38
MGSCv37964,233,433 - 64,557,012 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36964,183,696 - 64,498,960 (+)NCBIMGSCv36mm8
Celera961,623,685 - 61,939,629 (+)NCBICelera
Cytogenetic Map9CNCBI
cM Map934.67NCBI
Megf11
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8873,787,568 - 74,113,228 (+)NCBIGRCr8
mRatBN7.2864,892,312 - 65,218,984 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl864,892,387 - 65,216,061 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.0869,859,256 - 70,191,070 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl869,971,778 - 70,184,742 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0869,568,692 - 69,891,815 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4868,658,535 - 68,923,692 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera864,298,446 - 64,625,927 (+)NCBICelera
Cytogenetic Map8q24NCBI
Megf11
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554509,355,060 - 9,632,119 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554509,355,134 - 9,634,747 (+)NCBIChiLan1.0ChiLan1.0
MEGF11
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21655,144,035 - 55,519,796 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11559,314,696 - 59,690,443 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01544,836,750 - 45,208,674 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11563,113,926 - 63,358,656 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1563,116,564 - 63,204,508 (-)Ensemblpanpan1.1panPan2
MEGF11
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13030,224,538 - 30,561,565 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3030,227,160 - 30,561,562 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3030,151,924 - 30,496,100 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03030,414,657 - 30,758,453 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.13030,344,360 - 30,688,485 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03030,407,550 - 30,751,734 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03030,648,503 - 30,993,300 (-)NCBIUU_Cfam_GSD_1.0
Megf11
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640108,268,548 - 108,589,136 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647126,114,429 - 26,437,449 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647126,119,146 - 26,437,057 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MEGF11
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1163,894,312 - 164,275,442 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11163,894,929 - 164,275,439 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21181,630,679 - 181,700,021 (-)NCBISscrofa10.2Sscrofa10.2susScr3
MEGF11
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12617,297,066 - 17,675,888 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666048123,766,336 - 124,148,801 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Megf11
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247816,497,144 - 6,693,967 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247816,395,567 - 6,695,605 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in MEGF11
77 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 15q22.31(chr15:64448836-65975439)x3 copy number gain See cases [RCV000052344] Chr15:64448836..65975439 [GRCh38]
Chr15:64741035..66267777 [GRCh37]
Chr15:62528088..64054831 [NCBI36]
Chr15:15q22.31		 pathogenic
NM_032445.2(MEGF11):c.3040G>A (p.Asp1014Asn) single nucleotide variant Malignant melanoma [RCV000070863] Chr15:65898029 [GRCh38]
Chr15:66190367 [GRCh37]
Chr15:63977421 [NCBI36]
Chr15:15q22.31		 not provided
NM_032445.2(MEGF11):c.1106C>T (p.Thr369Ile) single nucleotide variant Malignant melanoma [RCV000070864] Chr15:65964914 [GRCh38]
Chr15:66257252 [GRCh37]
Chr15:64044306 [NCBI36]
Chr15:15q22.31		 not provided
NM_032445.2(MEGF11):c.762+3479A>G single nucleotide variant Lung cancer [RCV000099620] Chr15:65977299 [GRCh38]
Chr15:66269637 [GRCh37]
Chr15:15q22.31		 uncertain significance
NM_032445.2(MEGF11):c.395-37608C>T single nucleotide variant Lung cancer [RCV000099621] Chr15:66020096 [GRCh38]
Chr15:66312434 [GRCh37]
Chr15:15q22.31		 uncertain significance
NM_032445.2(MEGF11):c.395-52259T>C single nucleotide variant Lung cancer [RCV000099622] Chr15:66034747 [GRCh38]
Chr15:66327085 [GRCh37]
Chr15:15q22.31		 uncertain significance
NM_032445.2(MEGF11):c.-9+57751T>G single nucleotide variant Lung cancer [RCV000099623] Chr15:66195854 [GRCh38]
Chr15:66488192 [GRCh37]
Chr15:15q22.31		 uncertain significance
GRCh38/hg38 15q22.2-26.3(chr15:59828460-101920998)x3 copy number gain See cases [RCV000142915] Chr15:59828460..101920998 [GRCh38]
Chr15:60120659..102461201 [GRCh37]
Chr15:57907951..100278724 [NCBI36]
Chr15:15q22.2-26.3		 pathogenic
GRCh37/hg19 15q22.31-26.3(chr15:64637227-102509910)x3 copy number gain See cases [RCV000240602] Chr15:64637227..102509910 [GRCh37]
Chr15:15q22.31-26.3		 pathogenic
GRCh37/hg19 15q22.1-26.3(chr15:59297293-102480888)x3 copy number gain not provided [RCV000415836] Chr15:59297293..102480888 [GRCh37]
Chr15:15q22.1-26.3		 likely pathogenic
GRCh37/hg19 15q15.1-26.3(chr15:41745084-102354798)x4 copy number gain See cases [RCV000447123] Chr15:41745084..102354798 [GRCh37]
Chr15:15q15.1-26.3		 pathogenic
GRCh37/hg19 15q11.2-26.3(chr15:20733395-102511616)x4 copy number gain See cases [RCV000447765] Chr15:20733395..102511616 [GRCh37]
Chr15:15q11.2-26.3		 pathogenic
GRCh37/hg19 15q11.2-26.3(chr15:22770422-102429112)x3 copy number gain See cases [RCV000510717] Chr15:22770422..102429112 [GRCh37]
Chr15:15q11.2-26.3		 pathogenic
GRCh37/hg19 15q11.2-26.3(chr15:22770422-102429112) copy number gain See cases [RCV000512019] Chr15:22770422..102429112 [GRCh37]
Chr15:15q11.2-26.3		 pathogenic
NM_001385028.1(MEGF11):c.1909G>A (p.Gly637Ser) single nucleotide variant Inborn genetic diseases [RCV003282030] Chr15:65922386 [GRCh38]
Chr15:66214724 [GRCh37]
Chr15:15q22.31		 uncertain significance
NM_001385028.1(MEGF11):c.695G>C (p.Cys232Ser) single nucleotide variant Inborn genetic diseases [RCV003246387] Chr15:65980845 [GRCh38]
Chr15:66273183 [GRCh37]
Chr15:15q22.31		 uncertain significance
NM_001385028.1(MEGF11):c.761C>T (p.Thr254Met) single nucleotide variant Inborn genetic diseases [RCV003250971] Chr15:65980779 [GRCh38]
Chr15:66273117 [GRCh37]
Chr15:15q22.31		 uncertain significance
Single allele duplication not provided [RCV000677926] Chr15:31115047..102354857 [GRCh37]
Chr15:15q13.2-26.3		 pathogenic
Single allele deletion Nemaline myopathy 6 [RCV000677940] Chr15:63414894..66439797 [GRCh37]
Chr15:15q22.2-22.31		 likely pathogenic
GRCh37/hg19 15q11.1-26.3(chr15:20016811-102493540)x3 copy number gain not provided [RCV000751155] Chr15:20016811..102493540 [GRCh37]
Chr15:15q11.1-26.3		 pathogenic
GRCh37/hg19 15q11.1-26.3(chr15:20071673-102461162)x3 copy number gain not provided [RCV000751156] Chr15:20071673..102461162 [GRCh37]
Chr15:15q11.1-26.3		 pathogenic
NM_001385028.1(MEGF11):c.2660T>C (p.Val887Ala) single nucleotide variant Inborn genetic diseases [RCV003271941] Chr15:65913787 [GRCh38]
Chr15:66206125 [GRCh37]
Chr15:15q22.31		 uncertain significance
NM_001385028.1(MEGF11):c.1702C>T (p.Pro568Ser) single nucleotide variant Inborn genetic diseases [RCV003241479] Chr15:65922943 [GRCh38]
Chr15:66215281 [GRCh37]
Chr15:15q22.31		 likely benign
NC_000015.9:g.(?_32964879)_(91358519_?)dup duplication Bloom syndrome [RCV001343104]|Familial colorectal cancer [RCV001325176] Chr15:32964879..91358519 [GRCh37]
Chr15:15q13.3-26.1		 uncertain significance
NC_000015.9:g.(?_66161924)_(69018313_?)dup duplication Neuronal ceroid lipofuscinosis [RCV003120802]|not provided [RCV002045713] Chr15:66161924..69018313 [GRCh37]
Chr15:15q22.31-23		 uncertain significance|no classifications from unflagged records
NM_001385028.1(MEGF11):c.1754G>T (p.Gly585Val) single nucleotide variant Inborn genetic diseases [RCV003263308] Chr15:65922891 [GRCh38]
Chr15:66215229 [GRCh37]
Chr15:15q22.31		 uncertain significance
NM_001385028.1(MEGF11):c.1211A>G (p.Gln404Arg) single nucleotide variant Inborn genetic diseases [RCV003256825] Chr15:65957623 [GRCh38]
Chr15:66249961 [GRCh37]
Chr15:15q22.31		 uncertain significance
NM_001385028.1(MEGF11):c.2147C>G (p.Ala716Gly) single nucleotide variant Inborn genetic diseases [RCV002772295] Chr15:65916896 [GRCh38]
Chr15:66209234 [GRCh37]
Chr15:15q22.31		 uncertain significance
NM_001385028.1(MEGF11):c.311C>T (p.Thr104Met) single nucleotide variant Inborn genetic diseases [RCV002969077] Chr15:66094485 [GRCh38]
Chr15:66386823 [GRCh37]
Chr15:15q22.31		 uncertain significance
NM_001385028.1(MEGF11):c.1681C>T (p.Arg561Cys) single nucleotide variant Inborn genetic diseases [RCV003012687] Chr15:65922964 [GRCh38]
Chr15:66215302 [GRCh37]
Chr15:15q22.31		 uncertain significance
NM_001385028.1(MEGF11):c.2531C>T (p.Ala844Val) single nucleotide variant Inborn genetic diseases [RCV002728960] Chr15:65913916 [GRCh38]
Chr15:66206254 [GRCh37]
Chr15:15q22.31		 uncertain significance
NM_001385028.1(MEGF11):c.332G>A (p.Arg111His) single nucleotide variant Inborn genetic diseases [RCV002946829] Chr15:66094464 [GRCh38]
Chr15:66386802 [GRCh37]
Chr15:15q22.31		 uncertain significance
NM_001385028.1(MEGF11):c.637G>C (p.Val213Leu) single nucleotide variant Inborn genetic diseases [RCV002689524] Chr15:65982246 [GRCh38]
Chr15:66274584 [GRCh37]
Chr15:15q22.31		 uncertain significance
NM_001385028.1(MEGF11):c.2557A>C (p.Thr853Pro) single nucleotide variant Inborn genetic diseases [RCV002997077] Chr15:65913890 [GRCh38]
Chr15:66206228 [GRCh37]
Chr15:15q22.31		 uncertain significance
NM_001385028.1(MEGF11):c.3008G>A (p.Gly1003Glu) single nucleotide variant Inborn genetic diseases [RCV002734302] Chr15:65906132 [GRCh38]
Chr15:66198470 [GRCh37]
Chr15:15q22.31		 uncertain significance
NM_001385028.1(MEGF11):c.1303G>A (p.Val435Ile) single nucleotide variant Inborn genetic diseases [RCV002693487] Chr15:65930928 [GRCh38]
Chr15:66223266 [GRCh37]
Chr15:15q22.31		 likely benign
NM_001385028.1(MEGF11):c.2239A>G (p.Lys747Glu) single nucleotide variant Inborn genetic diseases [RCV002691853] Chr15:65916253 [GRCh38]
Chr15:66208591 [GRCh37]
Chr15:15q22.31		 uncertain significance
NM_001385028.1(MEGF11):c.3401C>T (p.Pro1134Leu) single nucleotide variant Inborn genetic diseases [RCV002952196] Chr15:65897956 [GRCh38]
Chr15:66190294 [GRCh37]
Chr15:15q22.31		 uncertain significance
NM_001385028.1(MEGF11):c.466C>T (p.Pro156Ser) single nucleotide variant Inborn genetic diseases [RCV002737404] Chr15:65982417 [GRCh38]
Chr15:66274755 [GRCh37]
Chr15:15q22.31		 uncertain significance
NM_001385028.1(MEGF11):c.2017G>A (p.Gly673Arg) single nucleotide variant Inborn genetic diseases [RCV002977910] Chr15:65918035 [GRCh38]
Chr15:66210373 [GRCh37]
Chr15:15q22.31		 uncertain significance
NM_001385028.1(MEGF11):c.247C>T (p.Arg83Trp) single nucleotide variant Inborn genetic diseases [RCV002980447] Chr15:66119140 [GRCh38]
Chr15:66411478 [GRCh37]
Chr15:15q22.31		 uncertain significance
NM_001385028.1(MEGF11):c.502C>T (p.Arg168Cys) single nucleotide variant Inborn genetic diseases [RCV002888301] Chr15:65982381 [GRCh38]
Chr15:66274719 [GRCh37]
Chr15:15q22.31		 uncertain significance
NM_001385028.1(MEGF11):c.160T>C (p.Cys54Arg) single nucleotide variant Inborn genetic diseases [RCV002888022] Chr15:66123939 [GRCh38]
Chr15:66416277 [GRCh37]
Chr15:15q22.31		 uncertain significance
NM_001385028.1(MEGF11):c.1880A>G (p.His627Arg) single nucleotide variant Inborn genetic diseases [RCV002767452] Chr15:65922415 [GRCh38]
Chr15:66214753 [GRCh37]
Chr15:15q22.31		 uncertain significance
NM_001385028.1(MEGF11):c.1385A>G (p.Asp462Gly) single nucleotide variant Inborn genetic diseases [RCV002709086] Chr15:65930846 [GRCh38]
Chr15:66223184 [GRCh37]
Chr15:15q22.31		 uncertain significance
NM_001385028.1(MEGF11):c.393C>A (p.Ser131Arg) single nucleotide variant Inborn genetic diseases [RCV002985022] Chr15:66094403 [GRCh38]
Chr15:66386741 [GRCh37]
Chr15:15q22.31		 uncertain significance
NM_001385028.1(MEGF11):c.1324T>C (p.Tyr442His) single nucleotide variant Inborn genetic diseases [RCV002985148] Chr15:65930907 [GRCh38]
Chr15:66223245 [GRCh37]
Chr15:15q22.31		 uncertain significance
NM_001385028.1(MEGF11):c.691C>A (p.Arg231Ser) single nucleotide variant Inborn genetic diseases [RCV002985842] Chr15:65980849 [GRCh38]
Chr15:66273187 [GRCh37]
Chr15:15q22.31		 uncertain significance
NM_001385028.1(MEGF11):c.3064A>G (p.Lys1022Glu) single nucleotide variant Inborn genetic diseases [RCV002956935] Chr15:65898926 [GRCh38]
Chr15:66191264 [GRCh37]
Chr15:15q22.31		 uncertain significance
NM_001385028.1(MEGF11):c.736G>A (p.Glu246Lys) single nucleotide variant Inborn genetic diseases [RCV003003740] Chr15:65980804 [GRCh38]
Chr15:66273142 [GRCh37]
Chr15:15q22.31		 uncertain significance
NM_001385028.1(MEGF11):c.2618G>A (p.Arg873Gln) single nucleotide variant Inborn genetic diseases [RCV002826993] Chr15:65913829 [GRCh38]
Chr15:66206167 [GRCh37]
Chr15:15q22.31		 uncertain significance
NM_001385028.1(MEGF11):c.856G>A (p.Val286Met) single nucleotide variant Inborn genetic diseases [RCV002930037] Chr15:65970596 [GRCh38]
Chr15:66262934 [GRCh37]
Chr15:15q22.31		 uncertain significance
NM_001385028.1(MEGF11):c.1855G>A (p.Ala619Thr) single nucleotide variant Inborn genetic diseases [RCV002764804] Chr15:65922440 [GRCh38]
Chr15:66214778 [GRCh37]
Chr15:15q22.31		 uncertain significance
NM_001385028.1(MEGF11):c.2656C>T (p.Arg886Cys) single nucleotide variant Inborn genetic diseases [RCV002813018] Chr15:65913791 [GRCh38]
Chr15:66206129 [GRCh37]
Chr15:15q22.31		 uncertain significance
NM_001385028.1(MEGF11):c.701G>T (p.Cys234Phe) single nucleotide variant Inborn genetic diseases [RCV002812952] Chr15:65980839 [GRCh38]
Chr15:66273177 [GRCh37]
Chr15:15q22.31		 uncertain significance
NM_001385028.1(MEGF11):c.1571C>T (p.Pro524Leu) single nucleotide variant Inborn genetic diseases [RCV002963877] Chr15:65929721 [GRCh38]
Chr15:66222059 [GRCh37]
Chr15:15q22.31		 uncertain significance
NM_001385028.1(MEGF11):c.2477C>T (p.Ala826Val) single nucleotide variant Inborn genetic diseases [RCV002793087] Chr15:65913970 [GRCh38]
Chr15:66206308 [GRCh37]
Chr15:15q22.31		 uncertain significance
NM_001385028.1(MEGF11):c.92G>T (p.Trp31Leu) single nucleotide variant Inborn genetic diseases [RCV002808477] Chr15:66128312 [GRCh38]
Chr15:66420650 [GRCh37]
Chr15:15q22.31		 uncertain significance
NM_001385028.1(MEGF11):c.2147C>T (p.Ala716Val) single nucleotide variant Inborn genetic diseases [RCV002714509] Chr15:65916896 [GRCh38]
Chr15:66209234 [GRCh37]
Chr15:15q22.31		 uncertain significance
NM_001385028.1(MEGF11):c.1096G>A (p.Ala366Thr) single nucleotide variant Inborn genetic diseases [RCV002965562] Chr15:65964924 [GRCh38]
Chr15:66257262 [GRCh37]
Chr15:15q22.31		 uncertain significance
NM_001385028.1(MEGF11):c.2251C>T (p.Arg751Cys) single nucleotide variant Inborn genetic diseases [RCV002769196] Chr15:65916241 [GRCh38]
Chr15:66208579 [GRCh37]
Chr15:15q22.31		 uncertain significance
NM_001385028.1(MEGF11):c.3304T>G (p.Ser1102Ala) single nucleotide variant Inborn genetic diseases [RCV002747516] Chr15:65898053 [GRCh38]
Chr15:66190391 [GRCh37]
Chr15:15q22.31		 uncertain significance
NM_001385028.1(MEGF11):c.236G>A (p.Arg79Gln) single nucleotide variant Inborn genetic diseases [RCV002855536] Chr15:66119151 [GRCh38]
Chr15:66411489 [GRCh37]
Chr15:15q22.31		 uncertain significance
NM_001385028.1(MEGF11):c.2620C>T (p.Arg874Trp) single nucleotide variant Inborn genetic diseases [RCV002724768] Chr15:65913827 [GRCh38]
Chr15:66206165 [GRCh37]
Chr15:15q22.31		 uncertain significance
NM_001385028.1(MEGF11):c.1682G>A (p.Arg561His) single nucleotide variant Inborn genetic diseases [RCV002679080] Chr15:65922963 [GRCh38]
Chr15:66215301 [GRCh37]
Chr15:15q22.31		 likely benign
NM_001385028.1(MEGF11):c.517G>A (p.Glu173Lys) single nucleotide variant Inborn genetic diseases [RCV002679352] Chr15:65982366 [GRCh38]
Chr15:66274704 [GRCh37]
Chr15:15q22.31		 uncertain significance
NM_001385028.1(MEGF11):c.2014A>G (p.Asn672Asp) single nucleotide variant Inborn genetic diseases [RCV003173564] Chr15:65918038 [GRCh38]
Chr15:66210376 [GRCh37]
Chr15:15q22.31		 uncertain significance
NM_001385028.1(MEGF11):c.1742G>C (p.Cys581Ser) single nucleotide variant Inborn genetic diseases [RCV003189477] Chr15:65922903 [GRCh38]
Chr15:66215241 [GRCh37]
Chr15:15q22.31		 uncertain significance
NM_001385028.1(MEGF11):c.328G>A (p.Gly110Ser) single nucleotide variant Inborn genetic diseases [RCV003210363] Chr15:66094468 [GRCh38]
Chr15:66386806 [GRCh37]
Chr15:15q22.31		 uncertain significance
NM_001385028.1(MEGF11):c.433C>G (p.Arg145Gly) single nucleotide variant Inborn genetic diseases [RCV003341001] Chr15:65982450 [GRCh38]
Chr15:66274788 [GRCh37]
Chr15:15q22.31		 uncertain significance
NM_001385028.1(MEGF11):c.550G>A (p.Gly184Arg) single nucleotide variant Inborn genetic diseases [RCV003364288] Chr15:65982333 [GRCh38]
Chr15:66274671 [GRCh37]
Chr15:15q22.31		 uncertain significance
NM_001385028.1(MEGF11):c.1020G>T (p.Lys340Asn) single nucleotide variant Inborn genetic diseases [RCV003384829] Chr15:65965000 [GRCh38]
Chr15:66257338 [GRCh37]
Chr15:15q22.31		 uncertain significance
NM_001385028.1(MEGF11):c.1690A>G (p.Ser564Gly) single nucleotide variant Inborn genetic diseases [RCV003364673] Chr15:65922955 [GRCh38]
Chr15:66215293 [GRCh37]
Chr15:15q22.31		 uncertain significance
NM_001385028.1(MEGF11):c.437G>T (p.Cys146Phe) single nucleotide variant Inborn genetic diseases [RCV003364059] Chr15:65982446 [GRCh38]
Chr15:66274784 [GRCh37]
Chr15:15q22.31		 uncertain significance
NM_001385028.1(MEGF11):c.406G>C (p.Asp136His) single nucleotide variant Inborn genetic diseases [RCV003381892] Chr15:65982477 [GRCh38]
Chr15:66274815 [GRCh37]
Chr15:15q22.31		 uncertain significance
NM_001385028.1(MEGF11):c.337G>A (p.Val113Ile) single nucleotide variant Inborn genetic diseases [RCV003381951] Chr15:66094459 [GRCh38]
Chr15:66386797 [GRCh37]
Chr15:15q22.31		 uncertain significance
NM_001385028.1(MEGF11):c.604G>A (p.Gly202Ser) single nucleotide variant Inborn genetic diseases [RCV003369740] Chr15:65982279 [GRCh38]
Chr15:66274617 [GRCh37]
Chr15:15q22.31		 uncertain significance
GRCh37/hg19 15q22.31(chr15:66349832-66790693)x3 copy number gain not provided [RCV003485069] Chr15:66349832..66790693 [GRCh37]
Chr15:15q22.31		 uncertain significance
NM_001385028.1(MEGF11):c.18G>A (p.Thr6=) single nucleotide variant not provided [RCV003390523] Chr15:66128386 [GRCh38]
Chr15:66420724 [GRCh37]
Chr15:15q22.31		 likely benign
NM_001385028.1(MEGF11):c.2491G>A (p.Glu831Lys) single nucleotide variant Inborn genetic diseases [RCV003359577] Chr15:65913956 [GRCh38]
Chr15:66206294 [GRCh37]
Chr15:15q22.31		 uncertain significance
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:9951
Count of miRNA genes:1342
Interacting mature miRNAs:1761
Transcripts:ENST00000288745, ENST00000360698, ENST00000395614, ENST00000395625, ENST00000409699, ENST00000422354, ENST00000455812, ENST00000469917, ENST00000474398, ENST00000478590, ENST00000478721, ENST00000484618, ENST00000489275, ENST00000490495, ENST00000493192, ENST00000562154, ENST00000564573
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Markers in Region
D15S213  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371566,452,958 - 66,453,076UniSTSGRCh37
GRCh371566,452,890 - 66,453,077UniSTSGRCh37
Build 361564,240,012 - 64,240,130RGDNCBI36
Celera1543,342,839 - 43,342,957RGD
Celera1543,342,771 - 43,342,958UniSTS
Cytogenetic Map15q22.31UniSTS
HuRef1543,289,634 - 43,289,754UniSTS
HuRef1543,289,566 - 43,289,755UniSTS
Marshfield Genetic Map1562.4UniSTS
Marshfield Genetic Map1562.4RGD
Genethon Genetic Map1562.0UniSTS
TNG Radiation Hybrid Map1524370.0UniSTS
deCODE Assembly Map1567.3UniSTS
Stanford-G3 RH Map152214.0UniSTS
GeneMap99-GB4 RH Map15229.45UniSTS
NCBI RH Map15416.8UniSTS
GeneMap99-G3 RH Map152209.0UniSTS
D15S651  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371566,304,020 - 66,304,130UniSTSGRCh37
Build 361564,091,074 - 64,091,184RGDNCBI36
Celera1543,181,925 - 43,182,029RGD
Cytogenetic Map15q22.31UniSTS
HuRef1543,128,680 - 43,128,784UniSTS
Marshfield Genetic Map1561.84UniSTS
Marshfield Genetic Map1561.84RGD
deCODE Assembly Map1566.5UniSTS
SHGC-17601  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371566,442,851 - 66,443,040UniSTSGRCh37
Build 361564,229,905 - 64,230,094RGDNCBI36
Celera1543,332,737 - 43,332,926RGD
Cytogenetic Map15q22.31UniSTS
HuRef1543,279,546 - 43,279,731UniSTS
Stanford-G3 RH Map152254.0UniSTS
Whitehead-RH Map15223.2UniSTS
Whitehead-YAC Contig Map15 UniSTS
NCBI RH Map15411.4UniSTS
RH92758  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371566,193,441 - 66,193,562UniSTSGRCh37
Build 361563,980,495 - 63,980,616RGDNCBI36
Celera1543,071,363 - 43,071,484RGD
Cytogenetic Map15q22.31UniSTS
HuRef1543,018,174 - 43,018,295UniSTS
GeneMap99-GB4 RH Map15231.16UniSTS
RH79766  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371566,308,866 - 66,308,969UniSTSGRCh37
Build 361564,095,920 - 64,096,023RGDNCBI36
Celera1543,186,764 - 43,186,867RGD
Cytogenetic Map15q22.31UniSTS
HuRef1543,133,519 - 43,133,622UniSTS
G63003  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371566,433,195 - 66,433,468UniSTSGRCh37
Build 361564,220,249 - 64,220,522RGDNCBI36
Celera1543,323,083 - 43,323,356RGD
Cytogenetic Map15q22.31UniSTS
HuRef1543,269,910 - 43,270,183UniSTS
TNG Radiation Hybrid Map1524345.0UniSTS
SHGC-154443  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371566,527,185 - 66,527,514UniSTSGRCh37
Build 361564,314,239 - 64,314,568RGDNCBI36
Celera1543,417,279 - 43,417,607RGD
Cytogenetic Map15q22.31UniSTS
HuRef1543,363,612 - 43,363,940UniSTS
TNG Radiation Hybrid Map1524226.0UniSTS
MEGF11__7389  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371566,187,444 - 66,188,357UniSTSGRCh37
Build 361563,974,498 - 63,975,411RGDNCBI36
Celera1543,065,366 - 43,066,279RGD
HuRef1543,012,177 - 43,013,090UniSTS
D15S1213  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371566,471,097 - 66,471,196UniSTSGRCh37
Build 361564,258,151 - 64,258,250RGDNCBI36
Celera1543,360,977 - 43,361,076RGD
Cytogenetic Map15q22.31UniSTS
HuRef1543,307,773 - 43,307,872UniSTS
D15S213  
Human AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map15q22.31UniSTS
TNG Radiation Hybrid Map1524370.0UniSTS
Stanford-G3 RH Map152214.0UniSTS
GeneMap99-GB4 RH Map15229.45UniSTS
NCBI RH Map15416.8UniSTS
GeneMap99-G3 RH Map152209.0UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component
High
Medium 1 6 1 6 1 1 501 20 16 13
Low 56 3 273 5 232 5 1639 21 2955 159 537 185 2 1 5 934
Below cutoff 2340 2937 1266 463 1619 302 2662 2142 254 172 859 1347 169 1198 1847 3

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001385028 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001385029 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001385030 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001385031 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001385032 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001385033 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001387150 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001387151 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_032445 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_169554 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_169555 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_169556 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_169557 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_169558 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017022670 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017022671 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017022672 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017022673 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017022674 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017022675 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047433165 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047433166 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047433167 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047433168 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047433169 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047433170 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054378984 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054378985 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054378986 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054378987 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054378988 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054378989 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054378990 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054378991 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054378992 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054378993 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054378994 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB058677 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB300051 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC011847 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC084854 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC087382 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC209298 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK090663 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL834326 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY358226 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC029999 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC117419 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC126313 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471082 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068263 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KF456072 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000288745   ⟹   ENSP00000288745
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1565,895,296 - 66,253,737 (-)Ensembl
RefSeq Acc Id: ENST00000395614   ⟹   ENSP00000378976
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1565,895,299 - 66,253,750 (-)Ensembl
RefSeq Acc Id: ENST00000409699   ⟹   ENSP00000386908
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1565,895,079 - 66,253,747 (-)Ensembl
RefSeq Acc Id: ENST00000422354   ⟹   ENSP00000414475
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1565,895,299 - 66,253,756 (-)Ensembl
RefSeq Acc Id: ENST00000455812   ⟹   ENSP00000401400
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1565,929,721 - 65,971,220 (-)Ensembl
RefSeq Acc Id: ENST00000469917
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1565,965,175 - 65,971,264 (-)Ensembl
RefSeq Acc Id: ENST00000474398
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1565,965,047 - 65,971,238 (-)Ensembl
RefSeq Acc Id: ENST00000478590
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1565,913,526 - 65,915,598 (-)Ensembl
RefSeq Acc Id: ENST00000478721
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1565,898,733 - 65,914,118 (-)Ensembl
RefSeq Acc Id: ENST00000484618
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1565,964,952 - 65,971,230 (-)Ensembl
RefSeq Acc Id: ENST00000489275   ⟹   ENSP00000478311
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1565,902,196 - 65,912,200 (-)Ensembl
RefSeq Acc Id: ENST00000490495   ⟹   ENSP00000456118
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1565,901,772 - 65,970,689 (-)Ensembl
RefSeq Acc Id: ENST00000493192
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1565,905,784 - 65,912,478 (-)Ensembl
RefSeq Acc Id: ENST00000562154   ⟹   ENSP00000483007
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1565,905,274 - 65,909,771 (-)Ensembl
RefSeq Acc Id: ENST00000564573   ⟹   ENSP00000477691
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1565,921,692 - 65,922,375 (-)Ensembl
RefSeq Acc Id: NM_001385028   ⟹   NP_001371957
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381565,895,299 - 66,253,750 (-)NCBI
T2T-CHM13v2.01563,704,723 - 64,075,393 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001385029   ⟹   NP_001371958
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381565,905,274 - 66,253,750 (-)NCBI
T2T-CHM13v2.01563,714,698 - 64,075,393 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001385030   ⟹   NP_001371959
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381565,895,299 - 66,253,750 (-)NCBI
T2T-CHM13v2.01563,704,723 - 64,075,393 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001385031   ⟹   NP_001371960
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381565,895,299 - 66,253,750 (-)NCBI
T2T-CHM13v2.01563,704,723 - 64,075,393 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001385032   ⟹   NP_001371961
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381565,905,274 - 66,253,750 (-)NCBI
T2T-CHM13v2.01563,714,698 - 64,075,393 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001385033   ⟹   NP_001371962
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381565,905,274 - 66,253,750 (-)NCBI
T2T-CHM13v2.01563,714,698 - 64,075,393 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001387150   ⟹   NP_001374079
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381565,895,299 - 66,253,750 (-)NCBI
T2T-CHM13v2.01563,704,723 - 64,075,393 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001387151   ⟹   NP_001374080
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381565,921,691 - 66,253,750 (-)NCBI
T2T-CHM13v2.01563,731,115 - 64,075,393 (-)NCBI
Sequence:
RefSeq Acc Id: NM_032445   ⟹   NP_115821
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381565,895,299 - 66,253,750 (-)NCBI
GRCh371566,187,634 - 66,546,075 (-)RGD
Build 361563,974,693 - 64,333,129 (-)NCBI Archive
Celera1543,065,556 - 43,436,170 (-)RGD
HuRef1543,012,367 - 43,382,504 (-)ENTREZGENE
CHM1_11566,305,506 - 66,664,221 (-)NCBI
T2T-CHM13v2.01563,704,723 - 64,075,393 (-)NCBI
Sequence:
RefSeq Acc Id: NR_169554
RefSeq Status: VALIDATED
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381565,895,299 - 66,253,750 (-)NCBI
T2T-CHM13v2.01563,704,723 - 64,075,393 (-)NCBI
Sequence:
RefSeq Acc Id: NR_169555
RefSeq Status: VALIDATED
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381565,895,299 - 66,253,750 (-)NCBI
T2T-CHM13v2.01563,704,723 - 64,075,393 (-)NCBI
Sequence:
RefSeq Acc Id: NR_169556
RefSeq Status: VALIDATED
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381565,895,299 - 66,253,750 (-)NCBI
T2T-CHM13v2.01563,704,723 - 64,075,393 (-)NCBI
Sequence:
RefSeq Acc Id: NR_169557
RefSeq Status: VALIDATED
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381565,895,299 - 66,253,750 (-)NCBI
T2T-CHM13v2.01563,704,723 - 64,075,393 (-)NCBI
Sequence:
RefSeq Acc Id: NR_169558
RefSeq Status: VALIDATED
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381565,895,299 - 66,253,750 (-)NCBI
T2T-CHM13v2.01563,704,723 - 64,075,393 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017022670   ⟹   XP_016878159
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381565,895,299 - 66,128,433 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017022671   ⟹   XP_016878160
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381565,895,299 - 66,128,433 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017022673   ⟹   XP_016878162
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381565,905,274 - 66,128,433 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017022674   ⟹   XP_016878163
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381565,895,299 - 65,971,593 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017022675   ⟹   XP_016878164
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381565,895,299 - 65,971,227 (-)NCBI
Sequence:
RefSeq Acc Id: XM_047433165   ⟹   XP_047289121
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381565,895,299 - 66,128,433 (-)NCBI
RefSeq Acc Id: XM_047433166   ⟹   XP_047289122
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381565,905,274 - 66,128,433 (-)NCBI
RefSeq Acc Id: XM_047433167   ⟹   XP_047289123
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381565,905,274 - 66,128,433 (-)NCBI
RefSeq Acc Id: XM_047433168   ⟹   XP_047289124
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381565,895,299 - 66,128,433 (-)NCBI
RefSeq Acc Id: XM_047433169   ⟹   XP_047289125
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381565,905,274 - 66,128,433 (-)NCBI
RefSeq Acc Id: XM_047433170   ⟹   XP_047289126
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381565,921,691 - 66,128,433 (-)NCBI
RefSeq Acc Id: XM_054378984   ⟹   XP_054234959
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.01563,704,723 - 63,949,826 (-)NCBI
RefSeq Acc Id: XM_054378985   ⟹   XP_054234960
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.01563,704,723 - 63,949,826 (-)NCBI
RefSeq Acc Id: XM_054378986   ⟹   XP_054234961
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.01563,704,723 - 63,949,826 (-)NCBI
RefSeq Acc Id: XM_054378987   ⟹   XP_054234962
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.01563,714,698 - 63,949,826 (-)NCBI
RefSeq Acc Id: XM_054378988   ⟹   XP_054234963
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.01563,714,698 - 63,949,826 (-)NCBI
RefSeq Acc Id: XM_054378989   ⟹   XP_054234964
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.01563,714,698 - 63,949,826 (-)NCBI
RefSeq Acc Id: XM_054378990   ⟹   XP_054234965
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.01563,708,151 - 63,949,826 (-)NCBI
RefSeq Acc Id: XM_054378991   ⟹   XP_054234966
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.01563,714,698 - 63,949,826 (-)NCBI
RefSeq Acc Id: XM_054378992   ⟹   XP_054234967
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.01563,704,723 - 63,781,918 (-)NCBI
RefSeq Acc Id: XM_054378993   ⟹   XP_054234968
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.01563,704,723 - 63,780,674 (-)NCBI
RefSeq Acc Id: XM_054378994   ⟹   XP_054234969
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.01563,731,115 - 63,949,826 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001371957 (Get FASTA)   NCBI Sequence Viewer  
  NP_001371958 (Get FASTA)   NCBI Sequence Viewer  
  NP_001371959 (Get FASTA)   NCBI Sequence Viewer  
  NP_001371960 (Get FASTA)   NCBI Sequence Viewer  
  NP_001371961 (Get FASTA)   NCBI Sequence Viewer  
  NP_001371962 (Get FASTA)   NCBI Sequence Viewer  
  NP_001374079 (Get FASTA)   NCBI Sequence Viewer  
  NP_001374080 (Get FASTA)   NCBI Sequence Viewer  
  NP_115821 (Get FASTA)   NCBI Sequence Viewer  
  XP_016878159 (Get FASTA)   NCBI Sequence Viewer  
  XP_016878160 (Get FASTA)   NCBI Sequence Viewer  
  XP_016878162 (Get FASTA)   NCBI Sequence Viewer  
  XP_016878163 (Get FASTA)   NCBI Sequence Viewer  
  XP_016878164 (Get FASTA)   NCBI Sequence Viewer  
  XP_047289121 (Get FASTA)   NCBI Sequence Viewer  
  XP_047289122 (Get FASTA)   NCBI Sequence Viewer  
  XP_047289123 (Get FASTA)   NCBI Sequence Viewer  
  XP_047289124 (Get FASTA)   NCBI Sequence Viewer  
  XP_047289125 (Get FASTA)   NCBI Sequence Viewer  
  XP_047289126 (Get FASTA)   NCBI Sequence Viewer  
  XP_054234959 (Get FASTA)   NCBI Sequence Viewer  
  XP_054234960 (Get FASTA)   NCBI Sequence Viewer  
  XP_054234961 (Get FASTA)   NCBI Sequence Viewer  
  XP_054234962 (Get FASTA)   NCBI Sequence Viewer  
  XP_054234963 (Get FASTA)   NCBI Sequence Viewer  
  XP_054234964 (Get FASTA)   NCBI Sequence Viewer  
  XP_054234965 (Get FASTA)   NCBI Sequence Viewer  
  XP_054234966 (Get FASTA)   NCBI Sequence Viewer  
  XP_054234967 (Get FASTA)   NCBI Sequence Viewer  
  XP_054234968 (Get FASTA)   NCBI Sequence Viewer  
  XP_054234969 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein A6BM72 (Get FASTA)   NCBI Sequence Viewer  
  AAI17420 (Get FASTA)   NCBI Sequence Viewer  
  AAI26314 (Get FASTA)   NCBI Sequence Viewer  
  AAQ88593 (Get FASTA)   NCBI Sequence Viewer  
  BAB47410 (Get FASTA)   NCBI Sequence Viewer  
  BAF64841 (Get FASTA)   NCBI Sequence Viewer  
  CAD38994 (Get FASTA)   NCBI Sequence Viewer  
  EAW77754 (Get FASTA)   NCBI Sequence Viewer  
  EAW77755 (Get FASTA)   NCBI Sequence Viewer  
  EAW77756 (Get FASTA)   NCBI Sequence Viewer  
  EAW77757 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSP00000288745
  ENSP00000288745.3
  ENSP00000378976
  ENSP00000378976.2
  ENSP00000386908
  ENSP00000386908.2
  ENSP00000401400.1
  ENSP00000414475
  ENSP00000414475.1
  ENSP00000456118.1
  ENSP00000477691.1
  ENSP00000478094.1
  ENSP00000480105.1
  ENSP00000480614.1
  ENSP00000483007.1
  ENSP00000488336.1
Reference Protein Sequences
RefSeq Acc Id: NP_115821   ⟸   NM_032445
- Peptide Label: isoform 2 precursor
- UniProtKB: Q8ND91 (UniProtKB/Swiss-Prot),   Q6UXS5 (UniProtKB/Swiss-Prot),   Q17R86 (UniProtKB/Swiss-Prot),   Q96KG6 (UniProtKB/Swiss-Prot),   A6BM72 (UniProtKB/Swiss-Prot),   A0A0G2JN40 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_016878159   ⟸   XM_017022670
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_016878160   ⟸   XM_017022671
- Peptide Label: isoform X2
- UniProtKB: A0A0G2JN40 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_016878163   ⟸   XM_017022674
- Peptide Label: isoform X8
- Sequence:
RefSeq Acc Id: XP_016878164   ⟸   XM_017022675
- Peptide Label: isoform X8
- Sequence:
RefSeq Acc Id: XP_016878162   ⟸   XM_017022673
- Peptide Label: isoform X4
- UniProtKB: A0A0G2JN40 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSP00000456118   ⟸   ENST00000490495
RefSeq Acc Id: ENSP00000401400   ⟸   ENST00000455812
RefSeq Acc Id: ENSP00000483007   ⟸   ENST00000562154
RefSeq Acc Id: ENSP00000288745   ⟸   ENST00000288745
RefSeq Acc Id: ENSP00000477691   ⟸   ENST00000564573
RefSeq Acc Id: ENSP00000386908   ⟸   ENST00000409699
RefSeq Acc Id: ENSP00000378976   ⟸   ENST00000395614
RefSeq Acc Id: ENSP00000478311   ⟸   ENST00000489275
RefSeq Acc Id: ENSP00000414475   ⟸   ENST00000422354
RefSeq Acc Id: NP_001371959   ⟸   NM_001385030
- Peptide Label: isoform 4
- UniProtKB: A0A0G2JLW8 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001371960   ⟸   NM_001385031
- Peptide Label: isoform 5
- UniProtKB: A0A0G2JLW8 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001371957   ⟸   NM_001385028
- Peptide Label: isoform 1 precursor
- UniProtKB: A0A0A0MS64 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001371961   ⟸   NM_001385032
- Peptide Label: isoform 6
- UniProtKB: A0A0G2JLW8 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001371962   ⟸   NM_001385033
- Peptide Label: isoform 7 precursor
- UniProtKB: A0A0G2JN40 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001371958   ⟸   NM_001385029
- Peptide Label: isoform 3 precursor
- UniProtKB: A0A0G2JN40 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001374079   ⟸   NM_001387150
- Peptide Label: isoform 2 precursor
- UniProtKB: Q8ND91 (UniProtKB/Swiss-Prot),   Q6UXS5 (UniProtKB/Swiss-Prot),   Q17R86 (UniProtKB/Swiss-Prot),   A6BM72 (UniProtKB/Swiss-Prot),   Q96KG6 (UniProtKB/Swiss-Prot),   A0A0G2JN40 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001374080   ⟸   NM_001387151
- Peptide Label: isoform 8 precursor
RefSeq Acc Id: XP_047289124   ⟸   XM_047433168
- Peptide Label: isoform X6
RefSeq Acc Id: XP_047289121   ⟸   XM_047433165
- Peptide Label: isoform X4
- UniProtKB: A0A0A0MS64 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_047289125   ⟸   XM_047433169
- Peptide Label: isoform X7
RefSeq Acc Id: XP_047289123   ⟸   XM_047433167
- Peptide Label: isoform X5
RefSeq Acc Id: XP_047289122   ⟸   XM_047433166
- Peptide Label: isoform X3
RefSeq Acc Id: XP_047289126   ⟸   XM_047433170
- Peptide Label: isoform X9
RefSeq Acc Id: XP_054234960   ⟸   XM_054378985
- Peptide Label: isoform X1
RefSeq Acc Id: XP_054234959   ⟸   XM_054378984
- Peptide Label: isoform X4
RefSeq Acc Id: XP_054234961   ⟸   XM_054378986
- Peptide Label: isoform X2
RefSeq Acc Id: XP_054234967   ⟸   XM_054378992
- Peptide Label: isoform X8
RefSeq Acc Id: XP_054234968   ⟸   XM_054378993
- Peptide Label: isoform X8
RefSeq Acc Id: XP_054234965   ⟸   XM_054378990
- Peptide Label: isoform X6
RefSeq Acc Id: XP_054234966   ⟸   XM_054378991
- Peptide Label: isoform X7
RefSeq Acc Id: XP_054234964   ⟸   XM_054378989
- Peptide Label: isoform X5
RefSeq Acc Id: XP_054234963   ⟸   XM_054378988
- Peptide Label: isoform X4
RefSeq Acc Id: XP_054234962   ⟸   XM_054378987
- Peptide Label: isoform X3
RefSeq Acc Id: XP_054234969   ⟸   XM_054378994
- Peptide Label: isoform X9
Protein Domains
EGF-like   EMI   Laminin EGF-like

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A6BM72-F1-model_v2 AlphaFold A6BM72 1-1044 view protein structure

Promoters
RGD ID:6792439
Promoter ID:HG_KWN:21699
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Lymphoblastoid
Transcripts:OTTHUMT00000329309
Position:
Human AssemblyChrPosition (strand)Source
Build 361563,993,376 - 63,994,247 (-)MPROMDB
RGD ID:6792441
Promoter ID:HG_KWN:21700
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Lymphoblastoid
Transcripts:OTTHUMT00000329314
Position:
Human AssemblyChrPosition (strand)Source
Build 361563,994,646 - 63,995,146 (-)MPROMDB
RGD ID:6792440
Promoter ID:HG_KWN:21701
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:K562
Transcripts:OTTHUMT00000329308,   OTTHUMT00000329310,   OTTHUMT00000329311,   OTTHUMT00000329312,   OTTHUMT00000329313
Position:
Human AssemblyChrPosition (strand)Source
Build 361564,050,521 - 64,051,021 (-)MPROMDB
RGD ID:7229859
Promoter ID:EPDNEW_H20674
Type:initiation region
Name:MEGF11_1
Description:multiple EGF like domains 11
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381566,253,750 - 66,253,810EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:29635 AgrOrtholog
COSMIC MEGF11 COSMIC
Ensembl Genes ENSG00000157890 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSG00000277848 UniProtKB/TrEMBL
Ensembl Transcript ENST00000288745 ENTREZGENE
  ENST00000288745.7 UniProtKB/Swiss-Prot
  ENST00000395614 ENTREZGENE
  ENST00000395614.6 UniProtKB/TrEMBL
  ENST00000409699 ENTREZGENE
  ENST00000409699.6 UniProtKB/Swiss-Prot
  ENST00000422354 ENTREZGENE
  ENST00000422354.6 UniProtKB/Swiss-Prot
  ENST00000455812.2 UniProtKB/TrEMBL
  ENST00000490495.5 UniProtKB/TrEMBL
  ENST00000562154.5 UniProtKB/TrEMBL
  ENST00000564573.1 UniProtKB/TrEMBL
  ENST00000614417.4 UniProtKB/TrEMBL
  ENST00000614717.1 UniProtKB/TrEMBL
  ENST00000615866.4 UniProtKB/TrEMBL
  ENST00000622356.1 UniProtKB/TrEMBL
Gene3D-CATH Laminin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tie2 ligand-binding domain superfamily UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000157890 GTEx
  ENSG00000277848 GTEx
HGNC ID HGNC:29635 ENTREZGENE
Human Proteome Map MEGF11 Human Proteome Map
InterPro EGF-like_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF-like_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EMI_domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Laminin_EGF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MEGF10/SREC1/2-like UniProtKB/TrEMBL
KEGG Report hsa:84465 UniProtKB/Swiss-Prot
NCBI Gene 84465 ENTREZGENE
OMIM 612454 OMIM
PANTHER INTEGRIN BETA-LIKE PROTEIN A-RELATED UniProtKB/TrEMBL
  LAMININ SUBUNIT ALPHA-5-RELATED UniProtKB/TrEMBL
  LAMININ SUBUNIT ALPHA-5-RELATED UniProtKB/TrEMBL
  MULTIPLE EGF LIKE DOMAINS 11 UniProtKB/TrEMBL
  MULTIPLE EPIDERMAL GROWTH FACTOR-LIKE DOMAINS PROTEIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MULTIPLE EPIDERMAL GROWTH FACTOR-LIKE DOMAINS PROTEIN 11 UniProtKB/Swiss-Prot
  SCAVENGER RECEPTOR CLASS F UniProtKB/TrEMBL
Pfam hEGF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Laminin_EGF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA144596411 PharmGKB
PRINTS EGFLAMININ UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE EGF_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_LAM_2 UniProtKB/TrEMBL
  EMI UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART EGF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_Lam UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A087WT97_HUMAN UniProtKB/TrEMBL
  A0A087X003_HUMAN UniProtKB/TrEMBL
  A0A0A0MS64 ENTREZGENE, UniProtKB/TrEMBL
  A0A0G2JLW8 ENTREZGENE, UniProtKB/TrEMBL
  A0A0G2JMV8_HUMAN UniProtKB/TrEMBL
  A0A0G2JN40 ENTREZGENE, UniProtKB/TrEMBL
  A6BM72 ENTREZGENE
  C9JYE7_HUMAN UniProtKB/TrEMBL
  H3BR81_HUMAN UniProtKB/TrEMBL
  MEG11_HUMAN UniProtKB/Swiss-Prot
  Q17R86 ENTREZGENE
  Q6UXS5 ENTREZGENE
  Q8ND91 ENTREZGENE
  Q96KG6 ENTREZGENE
UniProt Secondary Q17R86 UniProtKB/Swiss-Prot
  Q6UXS5 UniProtKB/Swiss-Prot
  Q8ND91 UniProtKB/Swiss-Prot
  Q96KG6 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-01-26 MEGF11  multiple EGF like domains 11    multiple EGF-like-domains 11  Symbol and/or name change 5135510 APPROVED