ADGRE2 (adhesion G protein-coupled receptor E2) - Rat Genome Database

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Gene: ADGRE2 (adhesion G protein-coupled receptor E2) Canis lupus familiaris
Analyze
Symbol: ADGRE2
Name: adhesion G protein-coupled receptor E2
RGD ID: 12196567
Description: ENCODES a protein that exhibits chondroitin sulfate binding (ortholog); INVOLVED IN cell adhesion (ortholog); cell migration (ortholog); granulocyte chemotaxis (ortholog); ASSOCIATED WITH dermatographia (ortholog); genetic disease (ortholog); vibratory urticaria (ortholog); FOUND IN leading edge membrane (ortholog)
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: egf-like module containing, mucin-like, hormone receptor-like 2; EGF-like module containing, mucin-like, hormone receptor-like sequence 2; EGF-like module receptor 2; EGF-like module-containing mucin-like hormone receptor-like 2; EMR2
RGD Orthologs
Human
Bonobo
Pig
Green Monkey
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12047,929,357 - 47,968,525 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2047,873,897 - 47,968,525 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2047,806,972 - 47,845,107 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02048,443,417 - 48,483,661 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2048,388,495 - 48,483,630 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12047,659,307 - 47,697,828 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02048,085,283 - 48,123,790 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02048,329,358 - 48,368,591 (-)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:17068111   PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
ADGRE2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12047,929,357 - 47,968,525 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2047,873,897 - 47,968,525 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2047,806,972 - 47,845,107 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02048,443,417 - 48,483,661 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2048,388,495 - 48,483,630 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12047,659,307 - 47,697,828 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02048,085,283 - 48,123,790 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02048,329,358 - 48,368,591 (-)NCBIUU_Cfam_GSD_1.0
ADGRE2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381914,724,171 - 14,778,560 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1914,732,392 - 14,778,560 (-)EnsemblGRCh38hg38GRCh38
GRCh371914,843,204 - 14,889,372 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361914,704,205 - 14,750,353 (-)NCBINCBI36Build 36hg18NCBI36
Build 341914,704,204 - 14,750,353NCBI
Celera1914,737,217 - 14,785,126 (-)NCBICelera
Cytogenetic Map19p13.12NCBI
HuRef1914,409,913 - 14,457,402 (-)NCBIHuRef
CHM1_11914,843,056 - 14,888,765 (-)NCBICHM1_1
T2T-CHM13v2.01914,850,478 - 14,906,112 (-)NCBIT2T-CHM13v2.0
LOC100974936
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22019,655,556 - 19,698,249 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11918,672,521 - 18,715,225 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01914,259,830 - 14,331,832 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11915,155,572 - 15,186,527 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1915,148,143 - 15,186,458 (-)Ensemblpanpan1.1panPan2
LOC100516957
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1263,853,304 - 63,900,460 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2264,549,001 - 64,553,222 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ADGRE2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1613,402,365 - 13,431,418 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl613,402,722 - 13,433,848 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660746,161,733 - 6,203,575 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in ADGRE2
627 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium
Low 5 1 12 6 6 6 6 4 1 7 4
Below cutoff 4 10 6 8 7 3 2

Sequence


Reference Sequences
RefSeq Acc Id: ENSCAFT00000025772   ⟹   ENSCAFP00000023936
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl2047,873,897 - 47,968,525 (-)Ensembl
RefSeq Acc Id: ENSCAFT00000025976   ⟹   ENSCAFP00000024114
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl2047,873,897 - 47,968,525 (-)Ensembl
RefSeq Acc Id: ENSCAFT00000025980   ⟹   ENSCAFP00000024118
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl2047,873,897 - 47,968,525 (-)Ensembl
RefSeq Acc Id: ENSCAFT00000025982   ⟹   ENSCAFP00000024120
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl2047,940,859 - 47,965,065 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845036550   ⟹   ENSCAFP00845028603
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl2048,388,495 - 48,483,630 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845036718   ⟹   ENSCAFP00845028747
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl2048,388,495 - 48,483,630 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845036964   ⟹   ENSCAFP00845028944
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl2048,443,842 - 48,483,630 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845037175   ⟹   ENSCAFP00845029112
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl2048,445,854 - 48,483,630 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845037341   ⟹   ENSCAFP00845029251
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl2048,452,863 - 48,483,630 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845037569   ⟹   ENSCAFP00845029436
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl2048,455,020 - 48,480,166 (-)Ensembl
RefSeq Acc Id: NM_001038667   ⟹   NP_001033756
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.12047,929,357 - 47,968,525 (-)NCBI
Dog10K_Boxer_Tasha2047,806,972 - 47,845,107 (-)NCBI
ROS_Cfam_1.02048,443,820 - 48,483,630 (-)NCBI
UMICH_Zoey_3.12047,659,307 - 47,697,828 (-)NCBI
UNSW_CanFamBas_1.02048,085,283 - 48,123,790 (-)NCBI
UU_Cfam_GSD_1.02048,329,358 - 48,368,591 (-)NCBI
Sequence:
RefSeq Acc Id: XM_038426513   ⟹   XP_038282441
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.02048,453,972 - 48,483,661 (-)NCBI
RefSeq Acc Id: XM_038426514   ⟹   XP_038282442
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.02048,443,417 - 48,483,661 (-)NCBI
RefSeq Acc Id: XM_038426515   ⟹   XP_038282443
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.02048,453,932 - 48,483,661 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_001033756   ⟸   NM_001038667
- Peptide Label: precursor
- UniProtKB: A0A8I3P6A7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000024120   ⟸   ENSCAFT00000025982
RefSeq Acc Id: ENSCAFP00000024118   ⟸   ENSCAFT00000025980
RefSeq Acc Id: ENSCAFP00000024114   ⟸   ENSCAFT00000025976
RefSeq Acc Id: ENSCAFP00000023936   ⟸   ENSCAFT00000025772
RefSeq Acc Id: XP_038282442   ⟸   XM_038426514
- Peptide Label: isoform X2
- UniProtKB: A0A8C0PFU3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038282443   ⟸   XM_038426515
- Peptide Label: isoform X3
- UniProtKB: A0A8C0SY38 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038282441   ⟸   XM_038426513
- Peptide Label: isoform X1
- UniProtKB: A0A8I3S275 (UniProtKB/TrEMBL),   A0A8C0PFU3 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCAFP00845029436   ⟸   ENSCAFT00845037569
RefSeq Acc Id: ENSCAFP00845029112   ⟸   ENSCAFT00845037175
RefSeq Acc Id: ENSCAFP00845028944   ⟸   ENSCAFT00845036964
RefSeq Acc Id: ENSCAFP00845029251   ⟸   ENSCAFT00845037341
RefSeq Acc Id: ENSCAFP00845028747   ⟸   ENSCAFT00845036718
RefSeq Acc Id: ENSCAFP00845028603   ⟸   ENSCAFT00845036550
Protein Domains
EGF-like   G-protein coupled receptors family 2 profile   GPS


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000023035 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030025361 UniProtKB/TrEMBL
  ENSCAFG00040016424 UniProtKB/TrEMBL
  ENSCAFG00845020704 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000025772.6 UniProtKB/TrEMBL
  ENSCAFT00000025976.5 UniProtKB/TrEMBL
  ENSCAFT00000025980.6 UniProtKB/TrEMBL
  ENSCAFT00000025982.6 UniProtKB/TrEMBL
  ENSCAFT00030046917.1 UniProtKB/TrEMBL
  ENSCAFT00030046935.1 UniProtKB/TrEMBL
  ENSCAFT00030046976.1 UniProtKB/TrEMBL
  ENSCAFT00040030295.1 UniProtKB/TrEMBL
  ENSCAFT00040030771.1 UniProtKB/TrEMBL
  ENSCAFT00040030908.1 UniProtKB/TrEMBL
  ENSCAFT00040030953.1 UniProtKB/TrEMBL
  ENSCAFT00040031076.1 UniProtKB/TrEMBL
  ENSCAFT00040031262.1 UniProtKB/TrEMBL
  ENSCAFT00845036550.1 UniProtKB/TrEMBL
  ENSCAFT00845036718.1 UniProtKB/TrEMBL
  ENSCAFT00845036964 ENTREZGENE
  ENSCAFT00845036964.1 UniProtKB/TrEMBL
  ENSCAFT00845037175.1 UniProtKB/TrEMBL
  ENSCAFT00845037341 ENTREZGENE
  ENSCAFT00845037341.1 UniProtKB/TrEMBL
  ENSCAFT00845037569.1 UniProtKB/TrEMBL
Gene3D-CATH 2.60.220.50 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Laminin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Rhodopsin 7-helix transmembrane proteins UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro EGF-like_Ca-bd_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF-like_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF-type_Asp/Asn_hydroxyl_site UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_Ca-bd_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GAIN_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_2-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_2_ADGRE2_ADGRE5 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_2_secretin-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_2_secretin-like_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Growth_fac_rcpt_cys_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report cfa:610750 UniProtKB/Swiss-Prot
NCBI Gene ADGRE2 ENTREZGENE
PANTHER ADHESION G PROTEIN-COUPLED RECEPTOR E2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ADHESION G-PROTEIN COUPLED RECEPTOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam 7tm_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_CA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS CD97PROTEIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCRSECRETIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE ASX_HYDROXYL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_CA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F2_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F2_4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART EGF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_CA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP EGF/Laminin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Family A G protein-coupled receptor-like UniProtKB/TrEMBL
  SSF57184 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8C0PFR1_CANLF UniProtKB/TrEMBL
  A0A8C0PFU3 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C0PSB5_CANLF UniProtKB/TrEMBL
  A0A8C0SUZ4_CANLF UniProtKB/TrEMBL
  A0A8C0SVS3_CANLF UniProtKB/TrEMBL
  A0A8C0SXM8_CANLF UniProtKB/TrEMBL
  A0A8C0SY24_CANLF UniProtKB/TrEMBL
  A0A8C0SY38 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C0Z052_CANLF UniProtKB/TrEMBL
  A0A8I3P6A7 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3P7L1_CANLF UniProtKB/TrEMBL
  A0A8I3PA05_CANLF UniProtKB/TrEMBL
  A0A8I3PDA8_CANLF UniProtKB/TrEMBL
  A0A8I3PE32_CANLF UniProtKB/TrEMBL
  A0A8I3S275 ENTREZGENE, UniProtKB/TrEMBL
  A0A8P0NHV8_CANLF UniProtKB/TrEMBL
  A0A8P0SKH2_CANLF UniProtKB/TrEMBL
  A0A8P0SKH4_CANLF UniProtKB/TrEMBL
  A0A8P0SKN5_CANLF UniProtKB/TrEMBL
  AGRE2_CANLF UniProtKB/Swiss-Prot, ENTREZGENE