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Gene: Dlk2 (delta like non-canonical Notch ligand 2) Mus musculus
Symbol: Dlk2
Name: delta like non-canonical Notch ligand 2
Description: Exhibits protein heterodimerization activity and protein homodimerization activity. Involved in negative regulation of Notch signaling pathway and regulation of fat cell differentiation. Predicted to localize to the plasma membrane. Is expressed in brain; esophagus; nasal cavity respiratory epithelium; pharynx; and spinal cord. Orthologous to human DLK2 (delta like non-canonical Notch ligand 2); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 3,3',5,5'-tetrabromobisphenol A; 4,4'-diaminodiphenylmethane.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: AI413481; delta-like 2 homolog; delta-like 2 homolog (Drosophila); DLK-2; EGF-like protein 9; EGF-like-domain, multiple 9; Egfl9; endothelial cell-specific protein S-1; epidermal growth factor-like protein 9; protein delta homolog 2
Homo sapiens (human) : DLK2 (delta like non-canonical Notch ligand 2)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Dlk2 (delta like non-canonical Notch ligand 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Dlk2 (delta like non-canonical Notch ligand 2)
Pan paniscus (bonobo/pygmy chimpanzee) : DLK2 (delta like non-canonical Notch ligand 2)
Canis lupus familiaris (dog) : DLK2 (delta like non-canonical Notch ligand 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Dlk2 (delta like non-canonical Notch ligand 2)
Sus scrofa (pig) : DLK2 (delta like non-canonical Notch ligand 2)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm381746,297,256 - 46,303,271 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371746,434,370 - 46,440,220 (+)NCBIGRCm37mm9NCBIm37
MGSCv361745,760,792 - 45,766,612 (+)NCBImm8
Celera1749,730,935 - 49,737,865 (+)NCBICelera
Cytogenetic Map17 CNCBI
JBrowse: View Region in Genome Browser (JBrowse)

References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
Nomenclature History
More on Dlk2
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1319321
Created: 2005-01-12
Species: Mus musculus
Last Modified: 2019-10-16
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.