Kctd11 (potassium channel tetramerisation domain containing 11) - Rat Genome Database
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Gene: Kctd11 (potassium channel tetramerisation domain containing 11) Mus musculus
Analyze
Symbol: Kctd11
Name: potassium channel tetramerisation domain containing 11
RGD ID: 1316134
MGI Page MGI
Description: Predicted to have identical protein binding activity. Involved in negative regulation of neuroblast proliferation; negative regulation of smoothened signaling pathway; and positive regulation of neuron differentiation. Localizes to cytoplasm. Is expressed in several structures, including 1st branchial arch; central nervous system; ectoplacental cone; primitive streak; and sensory organ. Orthologous to human KCTD11 (potassium channel tetramerization domain containing 11); INTERACTS WITH benzo[a]pyrene; cadmium dichloride; carbon nanotube.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: AF465352; BTB/POZ domain-containing protein KCTD11; potassium channel tetramerization domain-containing protein 11; R; Ren; retinoic acid, EGF, and NGF upregulated; RING-type E3 ubiquitin transferase KCTD11; RING-type E3 ubiquitin transferase subunit KCTD11
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391169,769,090 - 69,771,811 (-)NCBIGRCm39mm39
GRCm381169,878,264 - 69,880,985 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1169,878,261 - 69,881,406 (-)EnsemblGRCm38mm10GRCm38
MGSCv371169,691,766 - 69,694,487 (-)NCBIGRCm37mm9NCBIm37
MGSCv361169,693,872 - 69,697,601 (-)NCBImm8
Celera1177,425,819 - 77,428,540 (-)NCBICelera
Cytogenetic Map11B3NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IDA)

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

Additional References at PubMed
PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12186855   PMID:12466851   PMID:12477932   PMID:15249678   PMID:15489334   PMID:16141072   PMID:16141073   PMID:16148242  
PMID:16602821   PMID:20081843   PMID:21267068   PMID:21873635  


Genomics

Comparative Map Data
Kctd11
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391169,769,090 - 69,771,811 (-)NCBIGRCm39mm39
GRCm381169,878,264 - 69,880,985 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1169,878,261 - 69,881,406 (-)EnsemblGRCm38mm10GRCm38
MGSCv371169,691,766 - 69,694,487 (-)NCBIGRCm37mm9NCBIm37
MGSCv361169,693,872 - 69,697,601 (-)NCBImm8
Celera1177,425,819 - 77,428,540 (-)NCBICelera
Cytogenetic Map11B3NCBI
KCTD11
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl177,351,889 - 7,354,944 (+)EnsemblGRCh38hg38GRCh38
GRCh38177,352,162 - 7,354,944 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37177,255,481 - 7,258,263 (+)NCBIGRCh37GRCh37hg19GRCh37
GRCh37177,255,208 - 7,258,263 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36177,195,932 - 7,198,987 (+)NCBINCBI36hg18NCBI36
Build 34177,196,204 - 7,198,984NCBI
Celera177,281,147 - 7,284,208 (+)NCBI
Cytogenetic Map17p13.1NCBI
HuRef177,149,261 - 7,152,322 (+)NCBIHuRef
CHM1_1177,263,983 - 7,267,038 (+)NCBICHM1_1
Kctd11
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21054,602,575 - 54,604,738 (-)NCBI
Rnor_6.0 Ensembl1056,489,552 - 56,491,715 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01056,489,552 - 56,491,715 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01056,234,671 - 56,236,834 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41056,722,761 - 56,724,924 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11056,737,084 - 56,737,783 (-)NCBI
Celera1053,756,583 - 53,758,746 (-)NCBICelera
Cytogenetic Map10q24NCBI
Kctd11
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049554679,564,905 - 9,567,020 (-)NCBIChiLan1.0ChiLan1.0
KCTD11
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1177,372,262 - 7,375,310 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl177,373,315 - 7,374,013 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0177,386,148 - 7,389,198 (+)NCBIMhudiblu_PPA_v0panPan3
KCTD11
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1532,305,898 - 32,308,737 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Kctd11
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_004936595644,098 - 647,475 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
KCTD11
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1252,698,834 - 52,699,649 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11252,698,155 - 52,700,965 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21254,916,992 - 54,919,775 (+)NCBISscrofa10.2Sscrofa10.2susScr3
KCTD11
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1166,730,139 - 6,733,225 (+)NCBI
ChlSab1.1 Ensembl166,731,246 - 6,731,944 (+)Ensembl
Kctd11
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247869,972,773 - 9,975,819 (+)NCBI

Position Markers
Kctd11  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381169,880,408 - 69,880,871UniSTSGRCm38
MGSCv371169,693,910 - 69,694,373UniSTSGRCm37
Celera1177,427,963 - 77,428,426UniSTS
Cytogenetic Map11B3UniSTS
cM Map11 UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
26884453Sklq16_mskull length QTL 16, 16 week (mouse)11330000072800000Mouse
13208559Wght10_mweight 10 (mouse)11400000089000000Mouse
13208558Lgth12_mbody length 12 (mouse)11400000095000000Mouse
1300905Scc6_mcolon tumor susceptibility 6 (mouse)Not determined11693027789128908Mouse
1357859Lvrq7_mliver weight QTL 7 (mouse)Not determined1112318637118131898Mouse
39128214Lwq20_mliver weight QTL 20 (mouse)1112318637118131898Mouse
4141894Nidd6k_mNidd6 on KK-A (mouse)Not determined1917420497007000Mouse
10412246Dfs2_mdental fluorosis suseptibility 2 (mouse)Not determined112185736495990405Mouse
13208569Bmiq10_mbody mass index QTL 10 (mouse)113600000085000000Mouse
1301328Mol4_mmodifier of LPS-response 4 (mouse)Not determined113639175083590530Mouse
1301788Lbw8_mlupus NZB x NZW 8 (mouse)Not determined113661246070618665Mouse
1301896Tria1_mT-cell receptor induced activation 1 (mouse)Not determined113672273870723028Mouse
4141853Skmw17_mskeletal muscle weight 17 (mouse)Not determined113719011571190238Mouse
10766457Nwa3_mNew Zealand White autoimmunity 3 (mouse)113812528972125383Mouse
11532698Sluc36a_msusceptibility to lung cancer 36a (mouse)114236579176365904Mouse
11532699Sluc36b_msusceptibility to lung cancer 36b (mouse)114236579176365904Mouse
4142300Ctrq3_mC. trachomatis resistance QTL 3 (mouse)Not determined114473921176963931Mouse
4141367Inf1_macute ozone induced inflammation (mouse)Not determined44739211113167183Mouse
4141000Nidd3_mnon-insulin-dependent diabetes mellitus 3 (mouse)Not determined4515120179151308Mouse
1302021Nidd1n_mnon-insulin-dependent diabetes mellitus 1 in NSY (mouse)Not determined114527504680087498Mouse
1357878Mastr_mmodifier of astrocytoma (mouse)Not determined114581775489927907Mouse
1300765Bbaa4_mB.burgdorferi-associated arthritis 4 (mouse)Not determined114629434180294436Mouse
1301988Bmd11_mbone mineral density 11 (mouse)Not determined114642858180428696Mouse
1301830Ssta4_msusceptibility to Salmonella typhimurium antigens 4 (mouse)Not determined115018736584187585Mouse
13524840Ppiq9a_mprepulse inhibition QTL 9a (mouse)115260355986603559Mouse
1300774Pgia7_mproteoglycan induced arthritis 7 (mouse)Not determined115349976287499911Mouse
4141830Pregq1_mpregnancy QTL 1 (mouse)Not determined115423592683842826Mouse
4141875Etax9_methanol induced ataxia 9 (mouse)Not determined5539415972319101Mouse
4142121Tmc1m2_mTmc1 modifier 2 (mouse)Not determined1156973201114267131Mouse
1300664Etohcta9_methanol conditioned taste aversion 9 (mouse)Not determined115786383491863932Mouse
10053682Eae45_mexperimental allergic encephalomyelitis susceptibility 45 (mouse)Not determined115859972974863932Mouse
1300924Ity2_mimmunity to S. typhimurium 2 (mouse)Not determined15861720487804412Mouse
4141982Skts-fp2_mskin tumor susceptibility in FVB and PWK 2 (mouse)Not determined5882844085175703Mouse
1301987Pid3_mprior incubation determinant 3 (mouse)Not determined116179599488808902Mouse
1301319Dautb4_mdopamine uptake transporter binding 4 (mouse)Not determined116226517996265327Mouse
27226730Tibmd1_mtibia midshaft diameter 1, 5 week (mouse)1162700000109500000Mouse
1301999Lmr15_mleishmaniasis resistance 15 (mouse)Not determined116342858181939647Mouse
10044004Stzid3_mstreptozotocin induced diabetes susceptibility 3 (mouse)Not determined116342858194173092Mouse
11039501Ltpr6a_mLeishmania tropica response 6a (mouse)116493951098939647Mouse
11039502Ltpr6b_mLeishmania tropica response 6b (mouse)116493951098939647Mouse
11039515Ltpr6_mLeishmania tropica response 6 (mouse)116493951098939647Mouse
1301546Pcir2_mperiosteal circumference 2 (mouse)Not determined1166842594100842826Mouse
1357766Si5lq6_mserum IGFBP-5 level QTL 6 (mouse)Not determined1166842594100842826Mouse
4141012Femwf6_mfemur work to failure 6 (mouse)Not determined66842594100842826Mouse
1301833Tbbmd5_mtotal body bone mineral density 5 (mouse)Not determined1166842594100842826Mouse
1300784Prdt3_mprion disease incubation time 3 (mouse)Not determined1166842594100842826Mouse
1300628Lgth6_mbody length 6 (mouse)Not determined1166842594100842826Mouse
4142316Ity2b_mimmunity to S. typhimurium 2b (mouse)Not determined116718736579923086Mouse
27226783Tibl5_mtibia length 5, 5 week (mouse)1168300000102000000Mouse
36049778Ars6_mantibody response to SARS-CoV 6, day 15, IgM (mouse)116910000072600000Mouse
36049779Ars7_mantibody response to SARS-CoV 7, day 29, IgG1 (mouse)116910000072600000Mouse
36049784Ars8_mantibody response to SARS-CoV 8, day 29, IgG2a+IgG2c (mouse)116910000072600000Mouse
36049785Ars9_mantibody response to SARS-CoV 9, day 29, IgM (mouse)116910000072600000Mouse
36049786Ars10_mantibody response to SARS-CoV 10, 4 days post-rechallenge, IgG2a+IgG2c (mouse)116910000072600000Mouse
36049787Ars11_mantibody response to SARS-CoV 11, 4 days post-rechallenge, IgM (mouse)116910000072600000Mouse
36049788Ars1_mantibody response to SARS-CoV 1, day 7, IgG1 (mouse)116910000072600000Mouse
36049789Ars2_mantibody response to SARS-CoV 2, day 7, IgG2a+IgG2c (mouse)116910000072600000Mouse
36049790Ars3_mantibody response to SARS-CoV 3, day 7, IgG2b (mouse)116910000072600000Mouse
36049791Ars4_mantibody response to SARS-CoV 4, day 7, IgG3 (mouse)116910000072600000Mouse
36049792Ars5_mantibody response to SARS-CoV 5, day 7, IgM (mouse)116910000072600000Mouse
35673314Ari2_mantibody response to influenza 2, day 10, IgG3 (mouse)116910000072600000Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:553
Count of miRNA genes:355
Interacting mature miRNAs:426
Transcripts:ENSMUST00000050555
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000050555   ⟹   ENSMUSP00000059107
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl1169,878,261 - 69,881,406 (-)Ensembl
RefSeq Acc Id: ENSMUST00000238978   ⟹   ENSMUSP00000159163
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl1169,878,265 - 69,880,985 (-)Ensembl
RefSeq Acc Id: NM_153143   ⟹   NP_694783
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391169,769,090 - 69,771,811 (-)NCBI
GRCm381169,878,264 - 69,880,985 (-)ENTREZGENE
MGSCv371169,691,766 - 69,694,487 (-)RGD
Celera1177,425,819 - 77,428,540 (-)RGD
cM Map11 ENTREZGENE
Sequence:
Reference Sequences
RefSeq Acc Id: NP_694783   ⟸   NM_153143
- UniProtKB: Q8K485 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSMUSP00000159163   ⟸   ENSMUST00000238978
RefSeq Acc Id: ENSMUSP00000059107   ⟸   ENSMUST00000050555
Protein Domains
BTB

Promoters
RGD ID:6822345
Promoter ID:MM_KWN:8133
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:NM_153143,   XM_484042_TMEM95
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361169,693,201 - 69,694,657 (-)MPROMDB
RGD ID:8675238
Promoter ID:EPDNEW_M15650
Type:initiation region
Name:Kctd11_1
Description:Mus musculus potassium channel tetramerisation domain containing11 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381169,880,953 - 69,881,013EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:2448712 AgrOrtholog
Ensembl Genes ENSMUSG00000046731 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000059107 UniProtKB/TrEMBL
  ENSMUSP00000159163 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000050555 UniProtKB/TrEMBL
  ENSMUST00000238978 ENTREZGENE, UniProtKB/Swiss-Prot
InterPro BTB/POZ_dom UniProtKB/TrEMBL
  SKP1/BTB/POZ_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  T1-type_BTB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:216858 UniProtKB/Swiss-Prot
MGD MGI:2448712 ENTREZGENE
NCBI Gene 216858 ENTREZGENE
Pfam BTB_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Kctd11 PhenoGen
SMART BTB UniProtKB/TrEMBL
Superfamily-SCOP SSF54695 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A5K1VVR8_MOUSE UniProtKB/TrEMBL
  KCD11_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE