EGFL8 (EGF like domain multiple 8)

Gene: EGFL8 (EGF like domain multiple 8) Pan paniscus

Analyze

Symbol:

EGFL8 (Ensembl: PPT2)

Name:

EGF like domain multiple 8 (Ensembl:palmitoyl-protein thioesterase 2)

RGD ID:

11900369

Description:

ENCODES a protein that exhibits calcium ion binding (inferred); signaling receptor binding (inferred); INVOLVED IN in utero embryonic development (ortholog); ASSOCIATED WITH genetic disease (ortholog); proteasome-associated autoinflammatory syndrome 1 (ortholog); FOUND IN cell surface (inferred); extracellular region (inferred); membrane (inferred)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

epidermal growth factor-like protein 8

RGD Orthologs

Alliance Genes

More Info

more info ...

Latest Assembly:

Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly

Position:

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	5	46,627,622 - 46,631,334 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	6	42,589,106 - 42,592,604 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	6	31,811,944 - 31,815,796 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	6	32,691,846 - 32,695,549 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	6	32,680,175 - 32,695,549 (+)	Ensembl	panpan1.1		panPan2

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

genetic disease (ISO)

proteasome-associated autoinflammatory syndrome 1 (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

in utero embryonic development (ISO)

Cellular Component

cell surface (IEA)

extracellular region (IEA)

membrane (IEA)

Molecular Function

calcium ion binding (IEA)

protein binding (ISO)

signaling receptor binding (IEA)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

EGFL8
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	5	46,627,622 - 46,631,334 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	6	42,589,106 - 42,592,604 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	6	31,811,944 - 31,815,796 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	6	32,691,846 - 32,695,549 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	6	32,680,175 - 32,695,549 (+)	Ensembl	panpan1.1		panPan2

EGFL8
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	6	32,164,595 - 32,168,281 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	6	32,164,595 - 32,168,281 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	6	32,132,372 - 32,136,058 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	6	32,240,383 - 32,244,040 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	6	32,241,920 - 32,243,711	NCBI
Celera	6	33,699,452 - 33,703,109 (+)	NCBI		Celera
Cytogenetic Map	6	p21.32	NCBI
HuRef	6	31,886,374 - 31,890,261 (+)	NCBI		HuRef
CHM1_1	6	32,134,866 - 32,138,546 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	6	32,017,785 - 32,021,472 (+)	NCBI		T2T-CHM13v2.0

Egfl8
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	17	34,832,174 - 34,835,536 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	17	34,832,323 - 34,834,945 (-)	Ensembl		GRCm39 Ensembl
GRCm38	17	34,613,349 - 34,616,562 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	17	34,613,349 - 34,615,971 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	17	34,750,295 - 34,752,916 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	17	34,221,410 - 34,224,027 (-)	NCBI		MGSCv36	mm8
Celera	17	37,708,523 - 37,711,144 (-)	NCBI		Celera
Cytogenetic Map	17	B1	NCBI
cM Map	17	18.19	NCBI

Egfl8
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	20	4,137,531 - 4,140,632 (+)	NCBI		GRCr8
mRatBN7.2	20	4,132,930 - 4,136,024 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	20	4,133,629 - 4,136,018 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	20	4,839,942 - 4,842,521 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	20	4,201,694 - 4,204,273 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	20	4,732,618 - 4,735,197 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	20	4,378,205 - 4,380,959 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	20	4,378,206 - 4,380,600 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	20	6,457,145 - 6,460,359 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	20	4,235,508 - 4,237,864 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	20	3,894,231 - 3,896,629 (-)	NCBI		Celera
Cytogenetic Map	20	p12	NCBI

Egfl8
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955437	631,619 - 633,315 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955437	630,099 - 633,592 (+)	NCBI	ChiLan1.0	ChiLan1.0

EGFL8
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	12	1,558,069 - 1,561,566 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	12	1,559,384 - 1,561,580 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	12	1,691,756 - 1,695,261 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	12	1,696,259 - 1,699,764 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	12	1,697,579 - 1,699,467 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	12	1,559,296 - 1,562,799 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	12	1,624,911 - 1,628,412 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	12	1,691,223 - 1,694,727 (+)	NCBI		UU_Cfam_GSD_1.0

EGFL8
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	7	24,201,632 - 24,204,971 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	7	24,201,129 - 24,205,133 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	7	28,021,599 - 28,025,803 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

EGFL8
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	17	39,864,006 - 39,867,730 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	17	39,864,328 - 39,876,947 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666044	32,063,973 - 32,067,726 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Egfl8
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624754	24,152,811 - 24,155,240 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624754	24,152,544 - 24,155,271 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_003829770	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_014345314	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063605256	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JARIFH020000005	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSPPAT00000064843 ⟹ ENSPPAP00000041915

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
PanPan1.1 Ensembl	6	32,680,175 - 32,690,935 (+)	Ensembl

RefSeq Acc Id:

ENSPPAT00000064849 ⟹ ENSPPAP00000041921

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
PanPan1.1 Ensembl	6	32,681,595 - 32,693,461 (+)	Ensembl

RefSeq Acc Id:

ENSPPAT00000064852 ⟹ ENSPPAP00000041924

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
PanPan1.1 Ensembl	6	32,681,595 - 32,682,915 (+)	Ensembl

RefSeq Acc Id:

ENSPPAT00000064853 ⟹ ENSPPAP00000041925

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
PanPan1.1 Ensembl	6	32,681,595 - 32,682,884 (+)	Ensembl

RefSeq Acc Id:

ENSPPAT00000064855 ⟹ ENSPPAP00000041927

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
PanPan1.1 Ensembl	6	32,692,839 - 32,695,549 (+)	Ensembl

RefSeq Acc Id:

XM_003829770 ⟹ XP_003829818

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
NHGRI_mPanPan1-v2	5	46,627,622 - 46,631,334 (+)	NCBI
NHGRI_mPanPan1	6	42,589,106 - 42,592,604 (+)	NCBI
Mhudiblu_PPA_v0	6	31,811,944 - 31,815,796 (+)	NCBI
PanPan1.1	6	32,691,846 - 32,695,549 (+)	NCBI

Sequence:

show sequence

CCACCCACCAGTCTGAGCTGCTTCTGCTGAGGCTGGTCTGCCTGAAGCCTCCCAGGAGAAAGAA
GCCAGCCTGTAGGGTCCAGCGTCAAAGCGAATCATGGGGTCCAGGGCTGAGCTGTGCACTCTCT
TAGGCGGATTCTCCTTCCTCCTGCTACTGATATCAGGCGAGGGGGCCAAGGGTGGATCCCTCAG
AGAGAGTCAGGGAGTCTGCTCCAAGCAGACACTGGTGGTCCCGCTCCGCTACAACGAGTCCTAC
AGCCAACCAGTGTACAAGCCCTACCTGACCTTGTGCGCTGGGAGGCGCATCTGCAGCACTTACA
GGACCATGTACCGCGTTATGTGGCGGGAGGTGAGGCGGGAGGTTCAGCAGACCCATGCAGTGTG
CTGCCAGGGCTGGAAGAAGCGGCACCCGGGGGCGCTCACCTGTGAAGCCATCTGCGCCAAGCCT
TGCCTGAACGGAGGCGTCTGCGTTAGGCCTGACCAGTGCGAGTGCGCTCCCGGCTGGGGAGGGA
AGCACTGTCATGTGGACGTGGATGAATGTAGGACCAGCATCACCCTCTGCTCGCACCGTTGTTT
TAATACGGCAGGCAGCTTCACCTGCGGCTGCCCCCATGACCTAGTGCTAAGCGTGGACGGGCGC
ACCTGCACGGAGGGGTCCCCAGAGCCCCCAACCAGTGCCAGCATACTCAGCGTGGCCGTTCGGG
AGGCGGAAAAAGATGAGCGCGCTCTGAAGCAGGAGATTCACGAGCTGCGAGGGCGCCTGGAGCG
GCTGGAGCAGTGGGCCGGTCAGGCTGGGGCCTGGGTCAGAGCGGTGCTGCCCGTGCCGCCTGAA
GAGCTGCAGCCAGAACAGGTGGCTGAGCTGTGGGGCCGGGGTGACCGGATCGAATCTCTCAGCG
ACCAGGTGCTGCTGCTGGAGGAGAGGCTAGGTGCCTGCTCCTGTGAGGACAACAGCCTGGGCCT
CGGCGTCAATCATCGATAAGAAGCCTCTACAGCACCCCTGCCCCCTAATTTATACAGAAACCGG
ACCCACTAATCCTCTGGGATTGGCCGACTGTGAGCTGCAGATAAGGCTATCAGCCACCAAAGAG
CAATGAACAATGGAAACTTCAGAGAGCTGAAGAAAGGGGGAGGCCTGTGTTCTTGGCCTGCCCC
TGAGTCTTCTGGCTGGGGGCAGGTTGCCTGGGCAAGAACTGCTTCTTCAATTCCTTAACAAATG
CAACCACCAAGCACCCAGATCTCTCTCTCTCTCTTTATTTTCAGTTTTTTGCTGTTATCCAGAT
AATTAATAAAAACCAACCACGCAAAACTGG

hide sequence

RefSeq Acc Id:

XM_063605256 ⟹ XP_063461326

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
NHGRI_mPanPan1-v2	5	46,628,440 - 46,631,334 (+)	NCBI

Protein Sequences


Protein RefSeqs	XP_003829818	(Get FASTA)	NCBI Sequence Viewer
	XP_063461326	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSPPAP00000041924.1
	ENSPPAP00000041925.1
	ENSPPAP00000041927.1

RefSeq Acc Id:

XP_003829818 ⟸ XM_003829770

- UniProtKB:

A0A2R9CS31 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MGSRAELCTLLGGFSFLLLLISGEGAKGGSLRESQGVCSKQTLVVPLRYNESYSQPVYKPYLTL
CAGRRICSTYRTMYRVMWREVRREVQQTHAVCCQGWKKRHPGALTCEAICAKPCLNGGVCVRPD
QCECAPGWGGKHCHVDVDECRTSITLCSHRCFNTAGSFTCGCPHDLVLSVDGRTCTEGSPEPPT
SASILSVAVREAEKDERALKQEIHELRGRLERLEQWAGQAGAWVRAVLPVPPEELQPEQVAELW
GRGDRIESLSDQVLLLEERLGACSCEDNSLGLGVNHR

hide sequence

RefSeq Acc Id:

ENSPPAP00000041921 ⟸ ENSPPAT00000064849

RefSeq Acc Id:

ENSPPAP00000041927 ⟸ ENSPPAT00000064855

RefSeq Acc Id:

ENSPPAP00000041924 ⟸ ENSPPAT00000064852

RefSeq Acc Id:

ENSPPAP00000041925 ⟸ ENSPPAT00000064853

RefSeq Acc Id:

ENSPPAP00000041915 ⟸ ENSPPAT00000064843

RefSeq Acc Id:	XP_063461326 ⟸ XM_063605256
- UniProtKB:	A0A2R9CS31 (UniProtKB/TrEMBL)

Protein Domains

EGF-like EMI

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSPPAG00000043555	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSPPAT00000064852.1	UniProtKB/TrEMBL
	ENSPPAT00000064853.1	UniProtKB/TrEMBL
	ENSPPAT00000064855.1	UniProtKB/TrEMBL
Gene3D-CATH	3.40.50.1820	UniProtKB/TrEMBL
	Laminin	UniProtKB/TrEMBL
InterPro	AB_hydrolase	UniProtKB/TrEMBL
	EGF-like_Ca-bd_dom	UniProtKB/TrEMBL
	EGF-like_dom	UniProtKB/TrEMBL
	EGF_Ca-bd_CS	UniProtKB/TrEMBL
	EMI_domain	UniProtKB/TrEMBL
KEGG Report	pps:100990471	UniProtKB/TrEMBL
NCBI Gene	EGFL8	ENTREZGENE
PANTHER	EGF-LIKE-DOMAIN, MULTIPLE 7, 8	UniProtKB/TrEMBL
	EPIDERMAL GROWTH FACTOR-LIKE PROTEIN 8	UniProtKB/TrEMBL
Pfam	EGF	UniProtKB/TrEMBL
	EGF_CA	UniProtKB/TrEMBL
	EMI	UniProtKB/TrEMBL
	Palm_thioest	UniProtKB/TrEMBL
PROSITE	EGF_1	UniProtKB/TrEMBL
	EGF_2	UniProtKB/TrEMBL
	EGF_3	UniProtKB/TrEMBL
	EGF_CA	UniProtKB/TrEMBL
	EMI	UniProtKB/TrEMBL
SMART	EGF	UniProtKB/TrEMBL
	EGF_CA	UniProtKB/TrEMBL
Superfamily-SCOP	EGF/Laminin	UniProtKB/TrEMBL
	SSF53474	UniProtKB/TrEMBL
UniProt	A0A2R9CIZ3_PANPA	UniProtKB/TrEMBL
	A0A2R9CJ10_PANPA	UniProtKB/TrEMBL
	A0A2R9CS31	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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