STEROID HORMONE BIOSYNTHETIC PATHWAY (PW:0000040)
Description
Steroid hormones play important roles in metabolism, growth and differentiation and in reproductive functions. The synthesis and release of steroid hormones are highly regulated by the hypothalamus-pituitary-adrenal axis. The precursor of all steroid hormones is cholesterol which is derived from diet or via de novo synthesis from acetyl-CoA. The chronic steroidogenic response involves the change in the expression of steroidogenic genes while the acute response involves the quick delivery of cholesterol to the site of the first enzymatic reaction. The rapid flux of cholesterol from the outer (OMM) to the inner (IMM) mitochondrial membrane is mediated by the StAR protein. The IMM is the site where Cyp11a1, the enzyme catalyzing the first and rate-limiting step in the steroid biosynthetic pathway, is located. Overall there are two major classes of enzymes: the heme-containing cytochrome P450 and the hydroxysteroid dehydrogenase enzymes. The members of the P450 superfamily that participate in the pathway are membrane-bound mitochondrial or endoplasmic reticulum (microsome) enzymes that utilize NADPH as an electron donor. Two proteins mediate the mitochondrial electron transfer - the flavin-containing Fdxr and the iron-sulfur Fdx1; only one protein mediates the microsomal electron transfer - the P450 (cytochrome) oxidoreductase Por with two flavin cofactors. Dehydrogenases are membrane-bound mitochondrial or microsomal enzymes that utilize NAD or NADPH depending on whether the reaction is oxidation or reduction. The 27-carbon cholesterol is converted to the C
21 pregnenolone in a series of three chemical reactions that together constitute the step catalyzed by Cyp11a1. From this point, the pathway diverges into the individual branches that lead to the synthesis of particular types of steroids at specific adrenal and gonadal locations. Pregnenolone is converted to progesterone, itself an important hormone, or to 17OH-pregnenolone by Hsd3b1 or Hsd3b2, and Cyp17a1, respectively. In the adrenal zona glomerulosa, progesterone is converted to the C
21 mineralocorticoid aldosterone via a number of steps in the aldosterone biosynthetic pathway. Either progesterone or 17OH-pregnenolone can lead to the formation of the C
21 glucocorticoid cortisol in the cortisol biosynthetic pathway in zona fasciculata. Cyp17a1 catalyzes both 17-hydroxylation and 17,20 lyase reactions. The lyase activity of the enzyme accounts for the formation of the C
19 androgen dehydroepiandrosterone DHEA in the zona reticularis. In the testosterone biosynthetic pathway, DHEA is converted to testosterone in the testis; in the beta-estradiol biosynthetic pathway, testosterone is converted to the C
18 estrogen estradiol in the ovaries.
To see the ontology report for annotations, GViewer and download click here [click to see the ontology report for related GO term -
GO:0006694 , associated KEGG map -
map00140 and related entry at Reactome -
REACT_11057.2 ]
The steroid hormone biosynthetic pathway is part of the Steroid Hormone Biosynthesis Pathway Suite and the Prostate Cancer Pathway Suite . Click the name of the suite to view the related pathways....(less)
Pathway Diagram:
Genes in Pathway:
G
Akr1c1
aldo-keto reductase family 1, member C1
ISO
SMPDB
SMP:00130
NCBI chr17:65,810,474...65,837,385
Ensembl chr17:65,810,475...65,837,326
G
Akr1d1
aldo-keto reductase family 1, member D1
IEA ISO
KEGG SMPDB
SMP:00130 rno:00140
NCBI chr 4:66,154,246...66,187,505
Ensembl chr 4:66,154,248...66,186,372
G
Comt
catechol-O-methyltransferase
IEA
KEGG
rno:00140
NCBI chr11:82,568,052...82,587,642
Ensembl chr11:82,568,025...82,587,642
G
Cyp11a1
cytochrome P450, family 11, subfamily a, polypeptide 1
ISO IEA
SMPDB KEGG RGD
PMID:18821018
SMP:00130 rno:00140, RGD:2325883
NCBI chr 8:58,422,807...58,434,342
Ensembl chr 8:58,404,669...58,434,338
G
Cyp11b1
cytochrome P450, family 11, subfamily b, polypeptide 1
IEA
KEGG
rno:00140
NCBI chr 7:106,772,597...106,780,536
Ensembl chr 7:106,718,274...106,779,278
G
Cyp11b2
cytochrome P450, family 11, subfamily b, polypeptide 2
IEA ISO
KEGG SMPDB
SMP:00130 rno:00140
NCBI chr 7:106,838,590...106,845,004
Ensembl chr 7:106,838,590...106,845,004
G
Cyp11b3
cytochrome P450, family 11, subfamily b, polypeptide 3
IEA ISO
KEGG SMPDB
SMP:00130 rno:00140
NCBI chr 7:106,808,559...106,814,048
Ensembl chr 7:106,808,559...106,814,048
G
Cyp17a1
cytochrome P450, family 17, subfamily a, polypeptide 1
ISO IEA
SMPDB KEGG RGD
PMID:18821018
SMP:00130 rno:00140, RGD:2325883
NCBI chr 1:245,535,462...245,543,148
Ensembl chr 1:245,535,462...245,541,573
G
Cyp19a1
cytochrome P450, family 19, subfamily a, polypeptide 1
ISO IEA
KEGG RGD
PMID:15583024
rno:00140, RGD:4889549
NCBI chr 8:54,552,978...54,580,375
Ensembl chr 8:54,553,165...54,580,758
G
Cyp1a1
cytochrome P450, family 1, subfamily a, polypeptide 1
IEA
KEGG
rno:00140
NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
G
Cyp1b1
cytochrome P450, family 1, subfamily b, polypeptide 1
IEA
KEGG
rno:00140
NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917
G
Cyp21a1
cytochrome P450, family 21, subfamily a, polypeptide 1
IEA
KEGG
rno:00140
NCBI chr20:4,020,217...4,026,923
Ensembl chr20:4,023,767...4,026,923
G
Cyp3a18
cytochrome P450, family 3, subfamily a, polypeptide 18
IEA
KEGG
rno:00140
NCBI chr12:8,880,509...8,930,382
Ensembl chr12:8,880,528...8,930,381
G
Cyp3a2
cytochrome P450, family 3, subfamily a, polypeptide 2
IEA
KEGG
rno:00140
NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008
G
Cyp3a23-3a1
cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1
IEA
KEGG
rno:00140
NCBI chr12:9,256,159...9,285,020
Ensembl chr12:9,254,475...9,285,030 Ensembl chr12:9,254,475...9,285,030
G
Cyp3a9
cytochrome P450, family 3, subfamily a, polypeptide 9
IEA
KEGG
rno:00140
NCBI chr12:16,806,222...16,846,428
Ensembl chr12:16,806,207...16,846,422
G
Cyp7a1
cytochrome P450 family 7 subfamily A member 1
IEA
KEGG
rno:00140
NCBI chr 5:19,376,979...19,386,676
Ensembl chr 5:19,376,974...19,386,688
G
Cyp7b1
cytochrome P450 family 7 subfamily B member 1
IEA
KEGG
rno:00140
NCBI chr 2:100,502,791...100,669,713
Ensembl chr 2:100,502,791...100,669,698
G
Fdx1
ferredoxin 1
ISO
RGD
PMID:18821018
RGD:2325883
NCBI chr 8:52,268,536...52,287,344
Ensembl chr 8:52,268,536...52,287,414
G
Fdxr
ferredoxin reductase
ISO
RGD
PMID:18821018
RGD:2325883
NCBI chr10:100,507,863...100,516,649
Ensembl chr10:100,507,865...100,516,658
G
Hsd11b1
hydroxysteroid 11-beta dehydrogenase 1
IEA ISO
KEGG SMPDB
SMP:00130 rno:00140
NCBI chr13:104,728,539...104,798,884
Ensembl chr13:104,728,539...104,788,687
G
Hsd11b2
hydroxysteroid 11-beta dehydrogenase 2
IEA ISO
KEGG SMPDB
SMP:00130 rno:00140
NCBI chr19:33,397,656...33,402,899
Ensembl chr19:33,397,656...33,402,899
G
Hsd17b1
hydroxysteroid (17-beta) dehydrogenase 1
IEA
KEGG
rno:00140
NCBI chr10:86,009,728...86,011,928
Ensembl chr10:86,009,728...86,011,927
G
Hsd17b12
hydroxysteroid (17-beta) dehydrogenase 12
IEA
KEGG
rno:00140
NCBI chr 3:79,990,048...80,113,556
Ensembl chr 3:79,990,056...80,113,617
G
Hsd17b2
hydroxysteroid (17-beta) dehydrogenase 2
IEA
KEGG
rno:00140
NCBI chr19:45,753,576...45,825,203
Ensembl chr19:45,753,574...45,825,202
G
Hsd17b3
hydroxysteroid (17-beta) dehydrogenase 3
IEA
KEGG
rno:00140
NCBI chr17:1,027,229...1,058,554
Ensembl chr17:1,027,229...1,058,554
G
Hsd17b6
hydroxysteroid (17-beta) dehydrogenase 6
IEA
KEGG
rno:00140
NCBI chr 7:422,466...442,008
Ensembl chr 7:422,480...442,425
G
Hsd17b7
hydroxysteroid (17-beta) dehydrogenase 7
IEA
KEGG
rno:00140
NCBI chr13:82,170,079...82,190,018
Ensembl chr13:82,173,179...82,190,017
G
Hsd17b8
hydroxysteroid (17-beta) dehydrogenase 8
IEA
KEGG
rno:00140
NCBI chr20:4,826,725...4,828,742
Ensembl chr20:4,822,026...4,828,742
G
Hsd3b1
hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1
ISO
SMPDB RGD
PMID:15583024
SMP:00130, RGD:4889549
NCBI chr 2:186,169,864...186,175,984
Ensembl chr 2:186,169,863...186,175,999
G
Hsd3b2
hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2
IEA ISO
KEGG SMPDB RGD
PMID:15583024
SMP:00130 rno:00140, RGD:4889549
NCBI chr 2:186,095,897...186,105,354
Ensembl chr 2:186,095,897...186,101,852
G
Hsd3b5
hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 5
IEA
KEGG
rno:00140
NCBI chr 2:186,008,944...186,028,417
Ensembl chr 2:186,008,943...186,020,393
G
Por
cytochrome p450 oxidoreductase
ISO
RGD
PMID:18821018
RGD:2325883
NCBI chr12:20,951,058...20,999,198
Ensembl chr12:20,951,058...20,999,245
G
Srd5a1
steroid 5 alpha-reductase 1
IEA
KEGG
rno:00140
NCBI chr 1:33,686,069...33,720,468
Ensembl chr 1:33,686,391...33,720,461
G
Srd5a2
steroid 5 alpha-reductase 2
IEA
KEGG
rno:00140
NCBI chr 6:21,426,225...21,465,727
Ensembl chr 6:21,426,215...21,462,112
G
Srd5a3
steroid 5 alpha-reductase 3
IEA
KEGG
rno:00140
NCBI chr14:32,046,408...32,060,796
Ensembl chr14:32,046,408...32,060,747
G
Star
steroidogenic acute regulatory protein
TAS
RGD
PMID:18821018
RGD:2325883
NCBI chr16:66,267,094...66,274,368
Ensembl chr16:66,264,807...66,271,672
G
Sts
steroid sulfatase
IEA
KEGG
rno:00140
NCBI chr X:42,225,131...42,233,403
Ensembl chr X:42,225,372...42,233,402
G
Sult1e1
sulfotransferase family 1E member 1
IEA
KEGG
rno:00140
NCBI chr14:20,422,324...20,439,562
Ensembl chr14:20,422,324...20,439,275
G
Sult2a2
sulfotransferase family 2A, dehydroepiandrosterone (DHEA)-preferring, member 2
IEA
KEGG
rno:00140
NCBI chr 1:75,909,585...75,976,600
Ensembl chr 1:75,839,716...75,976,579
G
Sult2b1
sulfotransferase family 2B member 1
IEA
KEGG
rno:00140
NCBI chr 1:96,200,155...96,261,295
Ensembl chr 1:96,200,156...96,261,295
G
Ugt1a1
UDP glucuronosyltransferase family 1 member A1
IEA
KEGG
rno:00140
NCBI chr 9:88,801,344...88,808,465
Ensembl chr 9:88,713,184...88,808,465
G
Ugt1a2
UDP glucuronosyltransferase 1 family, polypeptide A2
IEA
KEGG
rno:00140
NCBI chr 9:88,791,216...88,808,465
Ensembl chr 9:88,713,184...88,808,465
G
Ugt1a3
UDP glycosyltransferase 1 family, polypeptide A3
IEA
KEGG
rno:00140
NCBI chr 9:88,780,328...88,808,465
Ensembl chr 9:88,713,184...88,808,465
G
Ugt1a5
UDP glucuronosyltransferase family 1 member A5
IEA
KEGG
rno:00140
NCBI chr 9:88,762,250...88,808,465
Ensembl chr 9:88,713,184...88,808,465
G
Ugt1a6
UDP glucuronosyltransferase family 1 member A6
IEA
KEGG
rno:00140
NCBI chr 9:88,747,213...88,808,465
Ensembl chr 9:88,713,184...88,808,465
G
Ugt1a7c
UDP glucuronosyltransferase 1 family, polypeptide A7C
IEA
KEGG
rno:00140
NCBI chr 9:88,739,577...88,808,465
Ensembl chr 9:88,713,184...88,808,465
G
Ugt1a8
UDP glucuronosyltransferase family 1 member A8
IEA
KEGG
rno:00140
NCBI chr 9:88,727,094...88,808,465
Ensembl chr 9:88,713,184...88,808,465
G
Ugt1a9
UDP glucuronosyltransferase family 1 member A9
IEA
KEGG
rno:00140
NCBI chr 9:88,696,981...88,808,465
Ensembl chr 9:88,713,184...88,808,465
G
Ugt2a1
UDP glucuronosyltransferase family 2 member A1
IEA
KEGG
rno:00140
NCBI chr14:20,521,018...20,545,934
Ensembl chr14:20,517,951...20,545,531
G
Ugt2a3
UDP glucuronosyltransferase family 2 member A3
IEA
KEGG
rno:00140
NCBI chr14:20,572,793...20,590,795
Ensembl chr14:20,572,808...20,590,729
G
Ugt2b
UDP glycosyltransferase 2 family, polypeptide B
IEA
KEGG
rno:00140
NCBI chr14:20,630,572...20,665,062
Ensembl chr14:20,630,250...20,651,776
G
Ugt2b1
UDP glucuronosyltransferase 2 family, polypeptide B1
IEA
KEGG
rno:00140
NCBI chr14:21,024,035...21,035,784
Ensembl chr14:21,024,006...21,035,986
G
Ugt2b37
UDP-glucuronosyltransferase 2 family, member 37
IEA
KEGG
rno:00140
NCBI chr14:20,817,285...20,833,917
Ensembl chr14:20,817,285...20,833,917
G
Cyp11a1
cytochrome P450, family 11, subfamily a, polypeptide 1
ISO
RGD
PMID:17926129
RGD:4892309
NCBI chr 8:58,422,807...58,434,342
Ensembl chr 8:58,404,669...58,434,338
G
Cyp11b1
cytochrome P450, family 11, subfamily b, polypeptide 1
ISO
RGD
PMID:15583024
RGD:4889549
NCBI chr 7:106,772,597...106,780,536
Ensembl chr 7:106,718,274...106,779,278
G
Cyp11b2
cytochrome P450, family 11, subfamily b, polypeptide 2
TAS
RGD
PMID:15583024
RGD:4889549
NCBI chr 7:106,838,590...106,845,004
Ensembl chr 7:106,838,590...106,845,004
G
Cyp21a1
cytochrome P450, family 21, subfamily a, polypeptide 1
ISO
RGD
PMID:15583024
RGD:4889549
NCBI chr20:4,020,217...4,026,923
Ensembl chr20:4,023,767...4,026,923
G
Fdx1
ferredoxin 1
ISO
RGD
PMID:18821018
RGD:2325883
NCBI chr 8:52,268,536...52,287,344
Ensembl chr 8:52,268,536...52,287,414
G
Fdxr
ferredoxin reductase
ISO
RGD
PMID:18821018
RGD:2325883
NCBI chr10:100,507,863...100,516,649
Ensembl chr10:100,507,865...100,516,658
G
Por
cytochrome p450 oxidoreductase
ISO
RGD
PMID:17926129
RGD:4892309
NCBI chr12:20,951,058...20,999,198
Ensembl chr12:20,951,058...20,999,245
G
Star
steroidogenic acute regulatory protein
ISO
RGD
PMID:18821018
RGD:2325883
NCBI chr16:66,267,094...66,274,368
Ensembl chr16:66,264,807...66,271,672
G
Cyp11b2
cytochrome P450, family 11, subfamily b, polypeptide 2
IDA
RGD
PMID:11832364
RGD:727991
NCBI chr 7:106,838,590...106,845,004
Ensembl chr 7:106,838,590...106,845,004
G
Cyp11b3
cytochrome P450, family 11, subfamily b, polypeptide 3
IDA
RGD
PMID:7829497
RGD:1299585
NCBI chr 7:106,808,559...106,814,048
Ensembl chr 7:106,808,559...106,814,048
G
Cyp11a1
cytochrome P450, family 11, subfamily a, polypeptide 1
ISO
RGD
PMID:17926129
RGD:4892309
NCBI chr 8:58,422,807...58,434,342
Ensembl chr 8:58,404,669...58,434,338
G
Cyp11b1
cytochrome P450, family 11, subfamily b, polypeptide 1
ISO
RGD
PMID:15583024
RGD:4889549
NCBI chr 7:106,772,597...106,780,536
Ensembl chr 7:106,718,274...106,779,278
G
Cyp11b2
cytochrome P450, family 11, subfamily b, polypeptide 2
ISO
RGD
PMID:15583024
RGD:4889549
NCBI chr 7:106,838,590...106,845,004
Ensembl chr 7:106,838,590...106,845,004
G
Cyp17a1
cytochrome P450, family 17, subfamily a, polypeptide 1
ISO
RGD
PMID:17926129
RGD:4892309
NCBI chr 1:245,535,462...245,543,148
Ensembl chr 1:245,535,462...245,541,573
G
Cyp21a1
cytochrome P450, family 21, subfamily a, polypeptide 1
ISO
RGD
PMID:15583024
RGD:4889549
NCBI chr20:4,020,217...4,026,923
Ensembl chr20:4,023,767...4,026,923
G
Fdx1
ferredoxin 1
ISO
RGD
PMID:18821018
RGD:2325883
NCBI chr 8:52,268,536...52,287,344
Ensembl chr 8:52,268,536...52,287,414
G
Fdxr
ferredoxin reductase
ISO
RGD
PMID:18821018
RGD:2325883
NCBI chr10:100,507,863...100,516,649
Ensembl chr10:100,507,865...100,516,658
G
Hsd3b1
hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1
ISO
RGD
PMID:15583024
RGD:4889549
NCBI chr 2:186,169,864...186,175,984
Ensembl chr 2:186,169,863...186,175,999
G
Hsd3b2
hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2
ISO
RGD
PMID:15583024
RGD:4889549
NCBI chr 2:186,095,897...186,105,354
Ensembl chr 2:186,095,897...186,101,852
G
Por
cytochrome p450 oxidoreductase
ISO
RGD
PMID:17926129
RGD:4892309
NCBI chr12:20,951,058...20,999,198
Ensembl chr12:20,951,058...20,999,245
G
Star
steroidogenic acute regulatory protein
ISO
RGD
PMID:18821018
RGD:2325883
NCBI chr16:66,267,094...66,274,368
Ensembl chr16:66,264,807...66,271,672
G
Cyp11a1
cytochrome P450, family 11, subfamily a, polypeptide 1
ISO
RGD
PMID:17926129
RGD:4892309
NCBI chr 8:58,422,807...58,434,342
Ensembl chr 8:58,404,669...58,434,338
G
Cyp17a1
cytochrome P450, family 17, subfamily a, polypeptide 1
ISO
RGD
PMID:17926129
RGD:4892309
NCBI chr 1:245,535,462...245,543,148
Ensembl chr 1:245,535,462...245,541,573
G
Cyp19a1
cytochrome P450, family 19, subfamily a, polypeptide 1
ISO
RGD
PMID:18821018
RGD:2325883
NCBI chr 8:54,552,978...54,580,375
Ensembl chr 8:54,553,165...54,580,758
G
Fdx1
ferredoxin 1
ISO
RGD
PMID:18821018
RGD:2325883
NCBI chr 8:52,268,536...52,287,344
Ensembl chr 8:52,268,536...52,287,414
G
Fdxr
ferredoxin reductase
ISO
RGD
PMID:18821018
RGD:2325883
NCBI chr10:100,507,863...100,516,649
Ensembl chr10:100,507,865...100,516,658
G
Hsd17b1
hydroxysteroid (17-beta) dehydrogenase 1
TAS ISO
RGD
PMID:15583024 PMID:18821018
RGD:4889549 , RGD:2325883
NCBI chr10:86,009,728...86,011,928
Ensembl chr10:86,009,728...86,011,927
G
Hsd17b2
hydroxysteroid (17-beta) dehydrogenase 2
ISO
RGD
PMID:15583024
RGD:4889549
NCBI chr19:45,753,576...45,825,203
Ensembl chr19:45,753,574...45,825,202
G
Hsd17b3
hydroxysteroid (17-beta) dehydrogenase 3
ISO
RGD
PMID:18821018
RGD:2325883
NCBI chr17:1,027,229...1,058,554
Ensembl chr17:1,027,229...1,058,554
G
Hsd3b1
hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1
ISO
RGD
PMID:15583024
RGD:4889549
NCBI chr 2:186,169,864...186,175,984
Ensembl chr 2:186,169,863...186,175,999
G
Hsd3b2
hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2
ISO
RGD
PMID:15583024
RGD:4889549
NCBI chr 2:186,095,897...186,105,354
Ensembl chr 2:186,095,897...186,101,852
G
Por
cytochrome p450 oxidoreductase
ISO
RGD
PMID:17926129
RGD:4892309
NCBI chr12:20,951,058...20,999,198
Ensembl chr12:20,951,058...20,999,245
G
Star
steroidogenic acute regulatory protein
ISO
RGD
PMID:18821018
RGD:2325883
NCBI chr16:66,267,094...66,274,368
Ensembl chr16:66,264,807...66,271,672
G
Sts
steroid sulfatase
ISO
RGD
PMID:21693170
RGD:6893583
NCBI chr X:42,225,131...42,233,403
Ensembl chr X:42,225,372...42,233,402
G
Sult1e1
sulfotransferase family 1E member 1
ISO
RGD
PMID:21693170
RGD:6893583
NCBI chr14:20,422,324...20,439,562
Ensembl chr14:20,422,324...20,439,275
G
Sult2a1
sulfotransferase family 2A member 1
ISO
RGD
PMID:18821018
RGD:2325883
NCBI chr 1:75,451,178...75,508,113
Ensembl chr 1:74,911,100...75,508,134
G
Cyp11a1
cytochrome P450, family 11, subfamily a, polypeptide 1
ISO
RGD
PMID:18821018
RGD:2325883
NCBI chr 8:58,422,807...58,434,342
Ensembl chr 8:58,404,669...58,434,338
G
Cyp17a1
cytochrome P450, family 17, subfamily a, polypeptide 1
ISO
RGD
PMID:18821018
RGD:2325883
NCBI chr 1:245,535,462...245,543,148
Ensembl chr 1:245,535,462...245,541,573
G
Fdx1
ferredoxin 1
ISO
RGD
PMID:18821018
RGD:2325883
NCBI chr 8:52,268,536...52,287,344
Ensembl chr 8:52,268,536...52,287,414
G
Fdxr
ferredoxin reductase
ISO
RGD
PMID:18821018
RGD:2325883
NCBI chr10:100,507,863...100,516,649
Ensembl chr10:100,507,865...100,516,658
G
Hsd17b2
hydroxysteroid (17-beta) dehydrogenase 2
ISO
RGD
PMID:15583024
RGD:4889549
NCBI chr19:45,753,576...45,825,203
Ensembl chr19:45,753,574...45,825,202
G
Hsd17b3
hydroxysteroid (17-beta) dehydrogenase 3
ISO
RGD
PMID:18821018
RGD:2325883
NCBI chr17:1,027,229...1,058,554
Ensembl chr17:1,027,229...1,058,554
G
Hsd3b1
hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1
ISO
RGD
PMID:15583024
RGD:4889549
NCBI chr 2:186,169,864...186,175,984
Ensembl chr 2:186,169,863...186,175,999
G
Hsd3b2
hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2
ISO
RGD
PMID:15583024
RGD:4889549
NCBI chr 2:186,095,897...186,105,354
Ensembl chr 2:186,095,897...186,101,852
G
Por
cytochrome p450 oxidoreductase
ISO
RGD
PMID:18821018
RGD:2325883
NCBI chr12:20,951,058...20,999,198
Ensembl chr12:20,951,058...20,999,245
G
Srd5a1
steroid 5 alpha-reductase 1
ISO
RGD
PMID:18821018
RGD:2325883
NCBI chr 1:33,686,069...33,720,468
Ensembl chr 1:33,686,391...33,720,461
G
Srd5a2
steroid 5 alpha-reductase 2
ISO
RGD
PMID:18821018
RGD:2325883
NCBI chr 6:21,426,225...21,465,727
Ensembl chr 6:21,426,215...21,462,112
G
Star
steroidogenic acute regulatory protein
TAS
RGD
PMID:18821018
RGD:2325883
NCBI chr16:66,267,094...66,274,368
Ensembl chr16:66,264,807...66,271,672
G
Sts
steroid sulfatase
ISO
RGD
PMID:21693170
RGD:6893583
NCBI chr X:42,225,131...42,233,403
Ensembl chr X:42,225,372...42,233,402
G
Sult2a1
sulfotransferase family 2A member 1
ISO
RGD
PMID:18821018
RGD:2325883
NCBI chr 1:75,451,178...75,508,113
Ensembl chr 1:74,911,100...75,508,134
Pathway Gene Annotations
Disease Annotations Associated with Genes in the steroid hormone biosynthetic pathway
Akr1c1 disorder of sexual development , Endometrial Neoplasms , endometriosis , Experimental Liver Cirrhosis , hypoparathyroidism-deafness-renal disease syndrome , lung non-small cell carcinoma , Neoplasms, Hormone-Dependent , Neoplastic Cell Transformation , obesity , osteoarthritis , polycystic ovary syndrome , schizophrenia Akr1d1 congenital bile acid synthesis defect , congenital bile acid synthesis defect 2 , genetic disease , hemochromatosis , pleomorphic xanthoastrocytoma Comt Acute Pain , alcohol dependence , alcohol use disorder , amphetamine abuse , Animal Mammary Neoplasms , attention deficit hyperactivity disorder , autism spectrum disorder , autistic disorder , Bardet-Biedl syndrome , bipolar disorder , Brain Injuries , breast cancer , Breast Neoplasms , bulimia nervosa , cannabis abuse , cannabis dependence , Catalepsy , Chemical and Drug Induced Liver Injury , Child Behavior Disorders , chromosome 22q11.2 deletion syndrome, distal , chromosome 22q11.2 microduplication syndrome , cocaine dependence , Cocaine-Related Disorders , cognitive disorder , DiGeorge syndrome , dilated cardiomyopathy , disease of mental health , drug dependence , Drug-Induced Dyskinesia , endometrial cancer , epilepsy , eumycotic mycetoma , Experimental Autoimmune Encephalomyelitis , Experimental Diabetes Mellitus , familial hypertrophic cardiomyopathy , Fatigue , Fetal Growth Retardation , fibromyalgia , Glucocorticoid Deficiency 5 , Hearing Loss, Cisplatin-Induced , hemorrhagic disease , hepatocellular carcinoma , heroin dependence , Hyperalgesia , hypertension , immunodeficiency 51 , intellectual disability , intermittent explosive disorder , leiomyoma , lung cancer , Lymphatic Metastasis , megacolon , Memory Disorders , morphine dependence , Musculoskeletal Pain , Neck Pain , neonatal abstinence syndrome , Neurodevelopmental Disorders , nicotine dependence , obesity , obsessive-compulsive disorder , opiate dependence , ovarian cancer , Pain , panic disorder , Paranoid Disorders , Parkinsonism , pathological gambling , pheochromocytoma , Polyarteritis Nodosa, Childhood-Onset , polycystic ovary syndrome , pre-eclampsia , primary immunodeficiency disease , prostate cancer , Prostatic Neoplasms , psoriasis , Recurrence , renal cell carcinoma , schizophrenia , Schizophrenia Spectrum and Other Psychotic Disorders , Temporomandibular Joint Disorders , Tobacco Use Disorder , uremia , urinary bladder cancer , velocardiofacial syndrome , Venous Thrombosis , vitiligo , withdrawal disorder Cyp11a1 46, XY Disorders of Sex Development , Adrenal Insufficiency , autism spectrum disorder , Bardet-Biedl syndrome , Bloom syndrome , Brain Injuries , Cardiomegaly , chronic obstructive pulmonary disease , colorectal cancer , congenital adrenal hyperplasia , Congenital Adrenal Hyperplasia due to 21 Hydroxylase Deficiency , congenital adrenal insufficiency , Endometrial Neoplasms , Experimental Diabetes Mellitus , Fetal Growth Retardation , genetic disease , hyperglycemia , hypertension , hypogonadism , Lipoid Congenital Adrenal Hyperplasia , nephrosis , schizophrenia , sciatic neuropathy , status epilepticus , type 2 diabetes mellitus Cyp11b1 adrenal cortical adenoma , brain infarction , congenital adrenal hyperplasia , Fetal Growth Retardation , hypertension , Left Ventricular Hypertrophy , primary hyperaldosteronism Cyp11b2 adrenal cortical adenoma , Albuminuria , Cardiomegaly , congenital adrenal hyperplasia , Congenital Adrenal Hyperplasia due to 11-Beta-Hydroxylase Deficiency , congestive heart failure , Diabetic Nephropathies , epidermolysis bullosa simplex with muscular dystrophy , Experimental Diabetes Mellitus , Fetal Growth Retardation , Fibrosis , genetic disease , glucocorticoid-remediable aldosteronism , heart disease , holoprosencephaly , hypertension , Hypoaldosteronism , Left Ventricular Hypertrophy , Metabolic Syndrome , myocardial infarction , myocarditis , pre-eclampsia , primary hyperaldosteronism , renal tubular acidosis , Stroke , type 2 diabetes mellitus Cyp11b3 adrenal cortical adenoma , autism spectrum disorder , Congenital Adrenal Hyperplasia due to 11-Beta-Hydroxylase Deficiency , corticosterone methyloxidase deficiency 1 , CORTICOSTERONE METHYLOXIDASE TYPE II DEFICIENCY , diabetes mellitus , Diabetic Nephropathies , dilated cardiomyopathy 1H , epidermolysis bullosa simplex with muscular dystrophy , genetic disease , glucocorticoid-remediable aldosteronism , holoprosencephaly , hypertension , Hypoaldosteronism , Left Ventricular Hypertrophy , Metabolic Syndrome , pre-eclampsia , primary hyperaldosteronism , Prostatic Neoplasms , Stroke , type 2 diabetes mellitus Cyp17a1 17,20-Lyase Deficiency, Isolated , amenorrhea , breast cancer , Breast Neoplasms , cholelithiasis , congenital adrenal hyperplasia , Congenital Adrenal Hyperplasia due to 21 Hydroxylase Deficiency , Congenital Adrenal Hyperplasia, Type 5 , desmoplastic/nodular medulloblastoma , Experimental Liver Cirrhosis , Female Infertility , gallbladder cancer , genetic disease , Genetic Predisposition to Disease , hepatocellular carcinoma , Hyperkalemia , hypogonadism , hypopituitarism , male infertility , malignant hypertension , metabolic dysfunction-associated steatotic liver disease , Neuralgia , nevoid basal cell carcinoma syndrome , Oligomenorrhea , osteoporosis , ovarian cyst , pancreatic cancer , polycystic ovary syndrome , primary ovarian insufficiency , prostate cancer , Prostatic Neoplasms , sciatic neuropathy , sexual health disorder , urinary bladder cancer Cyp19a1 adenocarcinoma , Alzheimer's disease , amenorrhea , aromatase excess syndrome , autism spectrum disorder , autistic disorder , bladder neck obstruction , Bloom syndrome , bone resorption disease , breast cancer , Breast Neoplasms , chronic obstructive pulmonary disease , colorectal cancer , Congenital Adrenal Hyperplasia due to 21 Hydroxylase Deficiency , Critical Illness , Diabetic Nephropathies , endometrial cancer , endometriosis , Esophageal Neoplasms , esophagus adenocarcinoma , Experimental Diabetes Mellitus , Female Infertility , Fibrosis , genetic disease , gestational diabetes , hypertension , hypogonadism , hypopituitarism , hypothyroidism , Kidney Reperfusion Injury , Knee Osteoarthritis , Neoplasm Metastasis , osteoporosis , ovarian cancer , ovarian disease , paraplegia , placental insufficiency , polycystic ovary syndrome , Postmenopausal Osteoporosis , primary ovarian insufficiency , prostate carcinoma in situ , Prostatic Neoplasms , prostatitis , protein-energy malnutrition , Recurrence , Reperfusion Injury , Sexual Infantilism , Sjogren's syndrome , steatotic liver disease , Tissue Adhesions , urethral obstruction , urinary bladder cancer Cyp1a1 acute kidney failure , Acute Lung Injury , acute lymphoblastic leukemia , acute myeloid leukemia , allergic contact dermatitis , allergic disease , ankylosing spondylitis , Arteritis , asthma , atopic dermatitis , autism spectrum disorder , Bardet-Biedl syndrome , Behcet's disease , biliary tract cancer , Birth Weight , Bloom syndrome , Bradycardia , breast cancer , Breast Neoplasms , bronchitis , Cardiac Fibrosis , Cardiomegaly , Chemical and Drug Induced Liver Injury , Chronic Bronchitis , Chronic Intermittent Hypoxia , chronic myeloid leukemia , chronic obstructive pulmonary disease , clubfoot , colitis , colorectal cancer , contact dermatitis , cystic fibrosis , diabetes mellitus , Digestive System Neoplasms , dilated cardiomyopathy , Drug Eruptions , end stage renal disease , endometrial cancer , endometriosis , esophageal cancer , esophagus squamous cell carcinoma , Experimental Diabetes Mellitus , Experimental Liver Neoplasms , Fetal Growth Retardation , gallbladder cancer , Graves' disease , Hamartoma , head and neck cancer , heart disease , Hematuria , hepatocellular carcinoma , Hepatomegaly , Hyperoxia , Hyperoxic Lung Injury , hypertension , Hypertriglyceridemia , hypertrophic cardiomyopathy , hypospadias , Inflammation , Jaundice , Keshan disease , Kidney Neoplasms , Liver Reperfusion Injury , long QT syndrome , lung cancer , Lung Injury , male infertility , Metabolic Side Effects of Drugs and Substances , Micronuclei, Chromosome-Defective , multiple myeloma , Nematode Infections , nephritis , Occupational Diseases , oral cavity cancer , oral squamous cell carcinoma , Parkinson's disease , Parkinsonism , periodontitis , peripheral vascular disease , pneumonia , polycystic ovary syndrome , porphyria cutanea tarda , Prenatal Exposure Delayed Effects , prostate cancer , Prostatic Neoplasms , psoriasis , psoriatic arthritis , pulmonary hypertension , Pulmonary Hypertension, Hypoxia-Induced , reactive arthritis , renal cell carcinoma , schizophrenia , Sepsis , Sinus Tachycardia , Sjogren's syndrome , Spontaneous Abortions , stomach cancer , systemic lupus erythematosus , type 2 diabetes mellitus , urinary bladder cancer , Ventricular Remodeling Cyp1b1 acute lymphoblastic leukemia , adenoma , anterior segment dysgenesis , anterior segment dysgenesis 5 , anterior segment dysgenesis 6 , breast adenocarcinoma , breast cancer , Breast Neoplasms , buphthalmos , Cardiac Fibrosis , Cardiomegaly , centronuclear myopathy 5 , Chemical and Drug Induced Liver Injury , chronic kidney disease , coloboma , Colorectal Neoplasms , contact dermatitis , esophagus squamous cell carcinoma , genetic disease , Glaucoma 3, Primary Infantile, B , glucose intolerance , Hepatomegaly , hydrophthalmos , hypertension , hypertrophic cardiomyopathy , juvenile glaucoma , lung adenocarcinoma , Lung Neoplasms , lung squamous cell carcinoma , Lynch syndrome , melanoma , Mouth Neoplasms , myocardial infarction , obesity , Ovarian Neoplasms , Peters anomaly , primary congenital glaucoma , primary open angle glaucoma , Prostatic Neoplasms , Pseudovaginal Perineoscrotal Hypospadias , RASopathy , squamous cell carcinoma , steatotic liver disease , urinary bladder cancer Cyp21a1 congenital adrenal hyperplasia Cyp3a18 autism spectrum disorder , nephrosis , pleomorphic xanthoastrocytoma , Prostatic Neoplasms Cyp3a2 alcohol dependence , Alcoholic Liver Diseases , anxiety disorder , breast cancer , Breast Neoplasms , Chemical and Drug Induced Liver Injury , cholestasis , end stage renal disease , familial Mediterranean fever , Familial Prostate Cancer , hepatitis C , Inflammation , osteosarcoma , ovarian carcinoma , pleomorphic xanthoastrocytoma , Prostatic Neoplasms , Subarachnoid Hemorrhage , Torsades de Pointes , type 2 diabetes mellitus , VITAMIN D-DEPENDENT RICKETS, TYPE 3 Cyp3a23-3a1 acute kidney failure , alcohol dependence , Chemical and Drug Induced Liver Injury , cholestasis , depressive disorder , hepatocellular adenoma , Inflammation , type 2 diabetes mellitus Cyp3a9 acute lymphoblastic leukemia , autism spectrum disorder , B-lymphoblastic leukemia/lymphoma , Chemotherapy-Induced Febrile Neutropenia , chronic myeloid leukemia , Drug-Induced Leukopenia , Drug-induced Neutropenia , essential hypertension , Experimental Liver Cirrhosis , kidney disease , liver cirrhosis , myasthenia gravis , Myeloid Leukemia, Chronic-Phase , nephrosis , oral submucous fibrosis , Pediatric Crohn's Disease , pleomorphic xanthoastrocytoma , Prostatic Neoplasms , Reperfusion Injury , thrombosis , toxic encephalopathy Cyp7a1 alcoholic hepatitis , autism spectrum disorder , cholestasis , Experimental Liver Cirrhosis , extrahepatic cholestasis , Hypercholesterolemia , metabolic dysfunction-associated steatohepatitis , Metabolic Syndrome Cyp7b1 adenocarcinoma , cholestasis , congenital bile acid synthesis defect , congenital bile acid synthesis defect 3 , genetic disease , hereditary spastic paraplegia , hereditary spastic paraplegia 5A , Joubert syndrome 3 , lipid metabolism disorder , liver disease , paraplegia , Prostatic Neoplasms , spastic ataxia , steatotic liver disease Fdx1 ataxia telangiectasia , Chromosome 11, Partial Trisomy 11q , intellectual disability , pancreatitis Fdxr Arterial Occlusive Diseases , Auditory Neuropathy , Auditory Neuropathy and Optic Atrophy , genetic disease , OPTIC ATROPHY-ATAXIA-PERIPHERAL NEUROPATHY-GLOBAL DEVELOPMENTAL DELAY SYNDROME Hsd11b1 Abdominal Obesity , allergic contact dermatitis , bladder exstrophy-epispadias-cloacal exstrophy complex , coronary artery disease , cortisone reductase deficiency , cortisone reductase deficiency 2 , Diabetic Nephropathies , essential hypertension , Experimental Diabetes Mellitus , familial hyperlipidemia , gastrointestinal stromal tumor , hyperglycemia , hypertension , Insulin Resistance , Left Ventricular Hypertrophy , Metabolic Syndrome , myocardial infarction , obesity , parathyroid carcinoma , pre-eclampsia , rheumatoid arthritis , status epilepticus , type 2 diabetes mellitus Hsd11b2 apparent mineralocorticoid excess syndrome , asthma , autosomal dominant dyskeratosis congenita 6 , fetal alcohol spectrum disorder , Fetal Growth Retardation , genetic disease , hypertension , inherited metabolic disorder , liver cirrhosis , myocardial infarction , nephrotic syndrome , obesity , Pregnancy Complications , type 1 diabetes mellitus , type 2 diabetes mellitus , ureteral obstruction Hsd17b1 autism spectrum disorder , endometriosis , invasive ductal carcinoma , mucopolysaccharidosis type IIIB , Prostatic Neoplasms , Spontaneous Abortions Hsd17b12 intellectual disability Hsd17b2 Endometrial Neoplasms , endometriosis , Experimental Liver Cirrhosis Hsd17b3 17-beta hydroxysteroid dehydrogenase 3 deficiency , Alzheimer's disease , disorder of sexual development , genetic disease , intellectual disability , Prostatic Neoplasms , pseudohermaphroditism , type 2 diabetes mellitus Hsd17b6 Experimental Liver Cirrhosis Hsd17b7 gastrointestinal stromal tumor , parathyroid carcinoma , polycystic ovary syndrome Hsd17b8 autosomal dominant intellectual developmental disorder 5 , proteasome-associated autoinflammatory syndrome 1 Hsd3b1 Alzheimer's disease , autism spectrum disorder , Hajdu-Cheney syndrome , hyperprolactinemia , hypertension , hypogonadism , hypospadias , hypothyroidism , PHGDH deficiency , polycystic ovary syndrome , Prostatic Neoplasms , sciatic neuropathy , type 2 diabetes mellitus Hsd3b2 Adrenal Hyperplasia 2 , Alzheimer's disease , congenital adrenal hyperplasia , cryptorchidism , genetic disease , Hajdu-Cheney syndrome , hepatocellular carcinoma , high grade glioma , hyperprolactinemia , hypertension , hypospadias , Hypospadias 1, X-Linked , Paranoid Disorders , PHGDH deficiency , polycystic ovary syndrome , Prostatic Neoplasms Por 46, XY Disorders of Sex Development , amenorrhea , Antley-Bixler syndrome , Antley-Bixler syndrome with disordered steroidogenesis , Antley-Bixler syndrome without disordered steroidogenesis , Chromosome 7q11.23 Deletion Syndrome, Distal, 1.2-MB , congenital adrenal hyperplasia , Congenital Adrenal Hyperplasia due to 21 Hydroxylase Deficiency , congestive heart failure , cytochrome P450 oxidoreductase deficiency , disorder of sexual development , Fine-Lubinsky Syndrome , genetic disease , gliosarcoma , Hirschsprung's disease , Hypotension , learning disability , Lung Injury , Musculoskeletal Abnormalities , Neoplastic Cell Transformation , neural tube defect , pleomorphic xanthoastrocytoma , primary ovarian insufficiency , urinary bladder cancer Srd5a1 breast carcinoma , Cardiomegaly , COVID-19 , endometriosis , Experimental Liver Cirrhosis , hyperprolactinemia , hypothyroidism , obesity , polycystic ovary syndrome , prostate cancer , prostatic hypertrophy , Prostatic Neoplasms , type 2 diabetes mellitus Srd5a2 alopecia , autism spectrum disorder , Autoinflammation with Infantile Enterocolitis , breast carcinoma , diabetes mellitus , Endometrial Neoplasms , endometriosis , familial cold autoinflammatory syndrome 4 , genetic disease , hereditary spastic paraplegia 4 , hyperprolactinemia , hypogonadism , hypospadias , Penis Agenesis , prostate cancer , prostatic hypertrophy , Prostatic Neoplasms , Pseudovaginal Perineoscrotal Hypospadias , xanthinuria , xanthinuria type II Srd5a3 autistic disorder , cone dystrophy , congenital disorder of glycosylation , congenital disorder of glycosylation Iq , congenital disorder of glycosylation type IIk , Creutzfeldt-Jakob disease , Developmental Disabilities , genetic disease , hemangioma , intellectual disability , Kahrizi syndrome , Muscle Hypotonia , Nervous System Malformations Star Cardiomegaly , congenital adrenal hyperplasia , Endometrial Neoplasms , Experimental Diabetes Mellitus , Fetal Growth Retardation , Fever , genetic disease , hereditary spastic paraplegia 54 , hypogonadism , hypogonadotropic hypogonadism 2 with or without anosmia , hypothyroidism , Lipoid Congenital Adrenal Hyperplasia , nephrosis , paraplegia , polycystic ovary syndrome , type 2 diabetes mellitus Sts alcoholic hepatitis , amenorrhea , attention deficit hyperactivity disorder , autism spectrum disorder , autistic disorder , cerebral palsy , COVID-19 , cryptorchidism , dystonia , Experimental Diabetes Mellitus , genetic disease , hypertension , Inflammation , Insulin Resistance , Neurodevelopmental Disorders , obesity , rheumatoid arthritis , schizophrenia , steatotic liver disease , Weight Gain , X-linked ichthyosis Sult1e1 alcoholic hepatitis , breast cancer , Chemical and Drug Induced Liver Injury , endometrial cancer , Experimental Liver Cirrhosis , liver disease , Neoplasm Metastasis , Prostatic Neoplasms , Reperfusion Injury Sult2b1 autism spectrum disorder , autosomal recessive congenital ichthyosis 1 , autosomal recessive congenital ichthyosis 14 , autosomal recessive congenital ichthyosis 2 , Chemical and Drug Induced Liver Injury , cholestasis , Colorectal Neoplasms , Endometrial Neoplasms , genetic disease , Inflammation , Prostatic Neoplasms Ugt1a1 acute kidney failure , Acute Liver Failure , autism spectrum disorder , bilirubin metabolic disorder , breast cancer , Chemical and Drug Induced Liver Injury , cholecystolithiasis , cholelithiasis , cholestasis , contact dermatitis , Crigler Najjar Syndrome, Type 2 , Crigler-Najjar syndrome , Crohn's disease , Drug-induced Neutropenia , Drug-Related Side Effects and Adverse Reactions , endometrial cancer , Gallstones , genetic disease , Gilbert syndrome , Gram-Negative Bacterial Infections , hematopoietic system disease , hepatitis B , Hereditary Hyperbilirubinemia , Hodgkin's lymphoma , Hyperbilirubinemia, Transient Familial Neonatal , hyperthyroidism , Inflammation , Jaundice , Joubert syndrome 22 , kernicterus , lung non-small cell carcinoma , myeloid leukemia , Neonatal Hyperbilirubinemia , neutropenia , ovarian cancer , Perlman syndrome , Polyuria , small cell carcinoma , Starvation , type 1 diabetes mellitus , type 2 diabetes mellitus Ugt1a2 bilirubin metabolic disorder , Crigler Najjar Syndrome, Type 2 , Crigler-Najjar syndrome , genetic disease , Gilbert syndrome , Hyperbilirubinemia, Transient Familial Neonatal , Joubert syndrome 22 , Perlman syndrome , schizophrenia Ugt1a3 bilirubin metabolic disorder , Crigler Najjar Syndrome, Type 2 , Crigler-Najjar syndrome , genetic disease , Gilbert syndrome , Hyperbilirubinemia, Transient Familial Neonatal , Joubert syndrome 22 , Perlman syndrome Ugt1a5 bilirubin metabolic disorder , celiac disease , Crigler Najjar Syndrome, Type 2 , Crigler-Najjar syndrome , genetic disease , Gilbert syndrome , Hyperbilirubinemia, Transient Familial Neonatal , Joubert syndrome 22 , Perlman syndrome Ugt1a6 autism spectrum disorder , bilirubin metabolic disorder , contact dermatitis , Crigler Najjar Syndrome, Type 2 , Crigler-Najjar syndrome , genetic disease , Gilbert syndrome , hepatitis B , Hyperbilirubinemia, Transient Familial Neonatal , Joubert syndrome 22 , Perlman syndrome , type 2 diabetes mellitus Ugt1a7c alcoholic pancreatitis , pancreatic cancer , type 2 diabetes mellitus Ugt1a8 Crigler-Najjar syndrome Ugt1a9 acute kidney failure , bilirubin metabolic disorder , Chemical and Drug Induced Liver Injury , cholangiocarcinoma , Crigler Najjar Syndrome, Type 2 , Crigler-Najjar syndrome , genetic disease , Gilbert syndrome , Hyperbilirubinemia, Transient Familial Neonatal , Joubert syndrome 22 , Perlman syndrome Ugt2a1 autism spectrum disorder Ugt2a3 autism spectrum disorder Ugt2b Experimental Liver Cirrhosis Ugt2b1 adenocarcinoma , Experimental Diabetes Mellitus , graft-versus-host disease , Lung Neoplasms , Prostatic Neoplasms
17,20-Lyase Deficiency, Isolated Cyp17a1 17-beta hydroxysteroid dehydrogenase 3 deficiency Hsd17b3 46, XY Disorders of Sex Development Cyp11a1 , Por Abdominal Obesity Hsd11b1 acute kidney failure Cyp1a1 , Cyp3a23-3a1 , Ugt1a1 , Ugt1a9 Acute Liver Failure Ugt1a1 Acute Lung Injury Cyp1a1 acute lymphoblastic leukemia Cyp1a1 , Cyp1b1 , Cyp3a9 acute myeloid leukemia Cyp1a1 Acute Pain Comt adenocarcinoma Cyp19a1 , Cyp7b1 , Ugt2b1 adenoma Cyp1b1 adrenal cortical adenoma Cyp11b1 , Cyp11b2 , Cyp11b3 Adrenal Hyperplasia 2 Hsd3b2 Adrenal Insufficiency Cyp11a1 Albuminuria Cyp11b2 alcohol dependence Comt , Cyp3a2 , Cyp3a23-3a1 alcohol use disorder Comt alcoholic hepatitis Cyp7a1 , Sts , Sult1e1 Alcoholic Liver Diseases Cyp3a2 alcoholic pancreatitis Ugt1a7c allergic contact dermatitis Cyp1a1 , Hsd11b1 allergic disease Cyp1a1 alopecia Srd5a2 Alzheimer's disease Cyp19a1 , Hsd17b3 , Hsd3b1 , Hsd3b2 amenorrhea Cyp17a1 , Cyp19a1 , Por , Sts amphetamine abuse Comt Animal Mammary Neoplasms Comt ankylosing spondylitis Cyp1a1 anterior segment dysgenesis Cyp1b1 anterior segment dysgenesis 5 Cyp1b1 anterior segment dysgenesis 6 Cyp1b1 Antley-Bixler syndrome Por Antley-Bixler syndrome with disordered steroidogenesis Por Antley-Bixler syndrome without disordered steroidogenesis Por anxiety disorder Cyp3a2 apparent mineralocorticoid excess syndrome Hsd11b2 aromatase excess syndrome Cyp19a1 Arterial Occlusive Diseases Fdxr Arteritis Cyp1a1 asthma Cyp1a1 , Hsd11b2 ataxia telangiectasia Fdx1 atopic dermatitis Cyp1a1 attention deficit hyperactivity disorder Comt , Sts Auditory Neuropathy Fdxr Auditory Neuropathy and Optic Atrophy Fdxr autism spectrum disorder Comt , Cyp11a1 , Cyp11b3 , Cyp19a1 , Cyp1a1 , Cyp3a18 , Cyp3a9 , Cyp7a1 , Hsd17b1 , Hsd3b1 , Srd5a2 , Sts , Sult2b1 , Ugt1a1 , Ugt1a6 , Ugt2a1 , Ugt2a3 autistic disorder Comt , Cyp19a1 , Srd5a3 , Sts Autoinflammation with Infantile Enterocolitis Srd5a2 autosomal dominant dyskeratosis congenita 6 Hsd11b2 autosomal dominant intellectual developmental disorder 5 Hsd17b8 autosomal recessive congenital ichthyosis 1 Sult2b1 autosomal recessive congenital ichthyosis 14 Sult2b1 autosomal recessive congenital ichthyosis 2 Sult2b1 B-lymphoblastic leukemia/lymphoma Cyp3a9 Bardet-Biedl syndrome Comt , Cyp11a1 , Cyp1a1 Behcet's disease Cyp1a1 biliary tract cancer Cyp1a1 bilirubin metabolic disorder Ugt1a1 , Ugt1a2 , Ugt1a3 , Ugt1a5 , Ugt1a6 , Ugt1a9 bipolar disorder Comt Birth Weight Cyp1a1 bladder exstrophy-epispadias-cloacal exstrophy complex Hsd11b1 bladder neck obstruction Cyp19a1 Bloom syndrome Cyp11a1 , Cyp19a1 , Cyp1a1 bone resorption disease Cyp19a1 Bradycardia Cyp1a1 brain infarction Cyp11b1 Brain Injuries Comt , Cyp11a1 breast adenocarcinoma Cyp1b1 breast cancer Comt , Cyp17a1 , Cyp19a1 , Cyp1a1 , Cyp1b1 , Cyp3a2 , Sult1e1 , Ugt1a1 breast carcinoma Srd5a1 , Srd5a2 Breast Neoplasms Comt , Cyp17a1 , Cyp19a1 , Cyp1a1 , Cyp1b1 , Cyp3a2 bronchitis Cyp1a1 bulimia nervosa Comt buphthalmos Cyp1b1 cannabis abuse Comt cannabis dependence Comt Cardiac Fibrosis Cyp1a1 , Cyp1b1 Cardiomegaly Cyp11a1 , Cyp11b2 , Cyp1a1 , Cyp1b1 , Srd5a1 , Star Catalepsy Comt celiac disease Ugt1a5 centronuclear myopathy 5 Cyp1b1 cerebral palsy Sts Chemical and Drug Induced Liver Injury Comt , Cyp1a1 , Cyp1b1 , Cyp3a2 , Cyp3a23-3a1 , Sult1e1 , Sult2b1 , Ugt1a1 , Ugt1a9 Chemotherapy-Induced Febrile Neutropenia Cyp3a9 Child Behavior Disorders Comt cholangiocarcinoma Ugt1a9 cholecystolithiasis Ugt1a1 cholelithiasis Cyp17a1 , Ugt1a1 cholestasis Cyp3a2 , Cyp3a23-3a1 , Cyp7a1 , Cyp7b1 , Sult2b1 , Ugt1a1 Chromosome 11, Partial Trisomy 11q Fdx1 chromosome 22q11.2 deletion syndrome, distal Comt chromosome 22q11.2 microduplication syndrome Comt Chromosome 7q11.23 Deletion Syndrome, Distal, 1.2-MB Por Chronic Bronchitis Cyp1a1 Chronic Intermittent Hypoxia Cyp1a1 chronic kidney disease Cyp1b1 chronic myeloid leukemia Cyp1a1 , Cyp3a9 chronic obstructive pulmonary disease Cyp11a1 , Cyp19a1 , Cyp1a1 clubfoot Cyp1a1 cocaine dependence Comt Cocaine-Related Disorders Comt cognitive disorder Comt colitis Cyp1a1 coloboma Cyp1b1 colorectal cancer Cyp11a1 , Cyp19a1 , Cyp1a1 Colorectal Neoplasms Cyp1b1 , Sult2b1 cone dystrophy Srd5a3 congenital adrenal hyperplasia Cyp11a1 , Cyp11b1 , Cyp11b2 , Cyp17a1 , Cyp21a1 , Hsd3b2 , Por , Star Congenital Adrenal Hyperplasia due to 11-Beta-Hydroxylase Deficiency Cyp11b2 , Cyp11b3 Congenital Adrenal Hyperplasia due to 21 Hydroxylase Deficiency Cyp11a1 , Cyp17a1 , Cyp19a1 , Por Congenital Adrenal Hyperplasia, Type 5 Cyp17a1 congenital adrenal insufficiency Cyp11a1 congenital bile acid synthesis defect Akr1d1 , Cyp7b1 congenital bile acid synthesis defect 2 Akr1d1 congenital bile acid synthesis defect 3 Cyp7b1 congenital disorder of glycosylation Srd5a3 congenital disorder of glycosylation Iq Srd5a3 congenital disorder of glycosylation type IIk Srd5a3 congestive heart failure Cyp11b2 , Por contact dermatitis Cyp1a1 , Cyp1b1 , Ugt1a1 , Ugt1a6 coronary artery disease Hsd11b1 corticosterone methyloxidase deficiency 1 Cyp11b3 CORTICOSTERONE METHYLOXIDASE TYPE II DEFICIENCY Cyp11b3 cortisone reductase deficiency Hsd11b1 cortisone reductase deficiency 2 Hsd11b1 COVID-19 Srd5a1 , Sts Creutzfeldt-Jakob disease Srd5a3 Crigler Najjar Syndrome, Type 2 Ugt1a1 , Ugt1a2 , Ugt1a3 , Ugt1a5 , Ugt1a6 , Ugt1a9 Crigler-Najjar syndrome Ugt1a1 , Ugt1a2 , Ugt1a3 , Ugt1a5 , Ugt1a6 , Ugt1a8 , Ugt1a9 Critical Illness Cyp19a1 Crohn's disease Ugt1a1 cryptorchidism Hsd3b2 , Sts cystic fibrosis Cyp1a1 cytochrome P450 oxidoreductase deficiency Por depressive disorder Cyp3a23-3a1 desmoplastic/nodular medulloblastoma Cyp17a1 Developmental Disabilities Srd5a3 diabetes mellitus Cyp11b3 , Cyp1a1 , Srd5a2 Diabetic Nephropathies Cyp11b2 , Cyp11b3 , Cyp19a1 , Hsd11b1 DiGeorge syndrome Comt Digestive System Neoplasms Cyp1a1 dilated cardiomyopathy Comt , Cyp1a1 dilated cardiomyopathy 1H Cyp11b3 disease of mental health Comt disorder of sexual development Akr1c1 , Hsd17b3 , Por drug dependence Comt Drug Eruptions Cyp1a1 Drug-Induced Dyskinesia Comt Drug-Induced Leukopenia Cyp3a9 Drug-induced Neutropenia Cyp3a9 , Ugt1a1 Drug-Related Side Effects and Adverse Reactions Ugt1a1 dystonia Sts end stage renal disease Cyp1a1 , Cyp3a2 endometrial cancer Comt , Cyp19a1 , Cyp1a1 , Sult1e1 , Ugt1a1 Endometrial Neoplasms Akr1c1 , Cyp11a1 , Hsd17b2 , Srd5a2 , Star , Sult2b1 endometriosis Akr1c1 , Cyp19a1 , Cyp1a1 , Hsd17b1 , Hsd17b2 , Srd5a1 , Srd5a2 epidermolysis bullosa simplex with muscular dystrophy Cyp11b2 , Cyp11b3 epilepsy Comt esophageal cancer Cyp1a1 Esophageal Neoplasms Cyp19a1 esophagus adenocarcinoma Cyp19a1 esophagus squamous cell carcinoma Cyp1a1 , Cyp1b1 essential hypertension Cyp3a9 , Hsd11b1 eumycotic mycetoma Comt Experimental Autoimmune Encephalomyelitis Comt Experimental Diabetes Mellitus Comt , Cyp11a1 , Cyp11b2 , Cyp19a1 , Cyp1a1 , Hsd11b1 , Star , Sts , Ugt2b1 Experimental Liver Cirrhosis Akr1c1 , Cyp17a1 , Cyp3a9 , Cyp7a1 , Hsd17b2 , Hsd17b6 , Srd5a1 , Sult1e1 , Ugt2b Experimental Liver Neoplasms Cyp1a1 extrahepatic cholestasis Cyp7a1 familial cold autoinflammatory syndrome 4 Srd5a2 familial hyperlipidemia Hsd11b1 familial hypertrophic cardiomyopathy Comt familial Mediterranean fever Cyp3a2 Familial Prostate Cancer Cyp3a2 Fatigue Comt Female Infertility Cyp17a1 , Cyp19a1 fetal alcohol spectrum disorder Hsd11b2 Fetal Growth Retardation Comt , Cyp11a1 , Cyp11b1 , Cyp11b2 , Cyp1a1 , Hsd11b2 , Star Fever Star fibromyalgia Comt Fibrosis Cyp11b2 , Cyp19a1 Fine-Lubinsky Syndrome Por gallbladder cancer Cyp17a1 , Cyp1a1 Gallstones Ugt1a1 gastrointestinal stromal tumor Hsd11b1 , Hsd17b7 genetic disease Akr1d1 , Cyp11a1 , Cyp11b2 , Cyp11b3 , Cyp17a1 , Cyp19a1 , Cyp1b1 , Cyp7b1 , Fdxr , Hsd11b2 , Hsd17b3 , Hsd3b2 , Por , Srd5a2 , Srd5a3 , Star , Sts , Sult2b1 , Ugt1a1 , Ugt1a2 , Ugt1a3 , Ugt1a5 , Ugt1a6 , Ugt1a9 Genetic Predisposition to Disease Cyp17a1 gestational diabetes Cyp19a1 Gilbert syndrome Ugt1a1 , Ugt1a2 , Ugt1a3 , Ugt1a5 , Ugt1a6 , Ugt1a9 Glaucoma 3, Primary Infantile, B Cyp1b1 gliosarcoma Por Glucocorticoid Deficiency 5 Comt glucocorticoid-remediable aldosteronism Cyp11b2 , Cyp11b3 glucose intolerance Cyp1b1 graft-versus-host disease Ugt2b1 Gram-Negative Bacterial Infections Ugt1a1 Graves' disease Cyp1a1 Hajdu-Cheney syndrome Hsd3b1 , Hsd3b2 Hamartoma Cyp1a1 head and neck cancer Cyp1a1 Hearing Loss, Cisplatin-Induced Comt heart disease Cyp11b2 , Cyp1a1 hemangioma Srd5a3 hematopoietic system disease Ugt1a1 Hematuria Cyp1a1 hemochromatosis Akr1d1 hemorrhagic disease Comt hepatitis B Ugt1a1 , Ugt1a6 hepatitis C Cyp3a2 hepatocellular adenoma Cyp3a23-3a1 hepatocellular carcinoma Comt , Cyp17a1 , Cyp1a1 , Hsd3b2 Hepatomegaly Cyp1a1 , Cyp1b1 Hereditary Hyperbilirubinemia Ugt1a1 hereditary spastic paraplegia Cyp7b1 hereditary spastic paraplegia 4 Srd5a2 hereditary spastic paraplegia 54 Star hereditary spastic paraplegia 5A Cyp7b1 heroin dependence Comt high grade glioma Hsd3b2 Hirschsprung's disease Por Hodgkin's lymphoma Ugt1a1 holoprosencephaly Cyp11b2 , Cyp11b3 hydrophthalmos Cyp1b1 Hyperalgesia Comt Hyperbilirubinemia, Transient Familial Neonatal Ugt1a1 , Ugt1a2 , Ugt1a3 , Ugt1a5 , Ugt1a6 , Ugt1a9 Hypercholesterolemia Cyp7a1 hyperglycemia Cyp11a1 , Hsd11b1 Hyperkalemia Cyp17a1 Hyperoxia Cyp1a1 Hyperoxic Lung Injury Cyp1a1 hyperprolactinemia Hsd3b1 , Hsd3b2 , Srd5a1 , Srd5a2 hypertension Comt , Cyp11a1 , Cyp11b1 , Cyp11b2 , Cyp11b3 , Cyp19a1 , Cyp1a1 , Cyp1b1 , Hsd11b1 , Hsd11b2 , Hsd3b1 , Hsd3b2 , Sts hyperthyroidism Ugt1a1 Hypertriglyceridemia Cyp1a1 hypertrophic cardiomyopathy Cyp1a1 , Cyp1b1 Hypoaldosteronism Cyp11b2 , Cyp11b3 hypogonadism Cyp11a1 , Cyp17a1 , Cyp19a1 , Hsd3b1 , Srd5a2 , Star hypogonadotropic hypogonadism 2 with or without anosmia Star hypoparathyroidism-deafness-renal disease syndrome Akr1c1 hypopituitarism Cyp17a1 , Cyp19a1 hypospadias Cyp1a1 , Hsd3b1 , Hsd3b2 , Srd5a2 Hypospadias 1, X-Linked Hsd3b2 Hypotension Por hypothyroidism Cyp19a1 , Hsd3b1 , Srd5a1 , Star immunodeficiency 51 Comt Inflammation Cyp1a1 , Cyp3a2 , Cyp3a23-3a1 , Sts , Sult2b1 , Ugt1a1 inherited metabolic disorder Hsd11b2 Insulin Resistance Hsd11b1 , Sts intellectual disability Comt , Fdx1 , Hsd17b12 , Hsd17b3 , Srd5a3 intermittent explosive disorder Comt invasive ductal carcinoma Hsd17b1 Jaundice Cyp1a1 , Ugt1a1 Joubert syndrome 22 Ugt1a1 , Ugt1a2 , Ugt1a3 , Ugt1a5 , Ugt1a6 , Ugt1a9 Joubert syndrome 3 Cyp7b1 juvenile glaucoma Cyp1b1 Kahrizi syndrome Srd5a3 kernicterus Ugt1a1 Keshan disease Cyp1a1 kidney disease Cyp3a9 Kidney Neoplasms Cyp1a1 Kidney Reperfusion Injury Cyp19a1 Knee Osteoarthritis Cyp19a1 learning disability Por Left Ventricular Hypertrophy Cyp11b1 , Cyp11b2 , Cyp11b3 , Hsd11b1 leiomyoma Comt lipid metabolism disorder Cyp7b1 Lipoid Congenital Adrenal Hyperplasia Cyp11a1 , Star liver cirrhosis Cyp3a9 , Hsd11b2 liver disease Cyp7b1 , Sult1e1 Liver Reperfusion Injury Cyp1a1 long QT syndrome Cyp1a1 lung adenocarcinoma Cyp1b1 lung cancer Comt , Cyp1a1 Lung Injury Cyp1a1 , Por Lung Neoplasms Cyp1b1 , Ugt2b1 lung non-small cell carcinoma Akr1c1 , Ugt1a1 lung squamous cell carcinoma Cyp1b1 Lymphatic Metastasis Comt Lynch syndrome Cyp1b1 male infertility Cyp17a1 , Cyp1a1 malignant hypertension Cyp17a1 megacolon Comt melanoma Cyp1b1 Memory Disorders Comt metabolic dysfunction-associated steatohepatitis Cyp7a1 metabolic dysfunction-associated steatotic liver disease Cyp17a1 Metabolic Side Effects of Drugs and Substances Cyp1a1 Metabolic Syndrome Cyp11b2 , Cyp11b3 , Cyp7a1 , Hsd11b1 Micronuclei, Chromosome-Defective Cyp1a1 morphine dependence Comt Mouth Neoplasms Cyp1b1 mucopolysaccharidosis type IIIB Hsd17b1 multiple myeloma Cyp1a1 Muscle Hypotonia Srd5a3 Musculoskeletal Abnormalities Por Musculoskeletal Pain Comt myasthenia gravis Cyp3a9 myeloid leukemia Ugt1a1 Myeloid Leukemia, Chronic-Phase Cyp3a9 myocardial infarction Cyp11b2 , Cyp1b1 , Hsd11b1 , Hsd11b2 myocarditis Cyp11b2 Neck Pain Comt Nematode Infections Cyp1a1 neonatal abstinence syndrome Comt Neonatal Hyperbilirubinemia Ugt1a1 Neoplasm Metastasis Cyp19a1 , Sult1e1 Neoplasms, Hormone-Dependent Akr1c1 Neoplastic Cell Transformation Akr1c1 , Por nephritis Cyp1a1 nephrosis Cyp11a1 , Cyp3a18 , Cyp3a9 , Star nephrotic syndrome Hsd11b2 Nervous System Malformations Srd5a3 neural tube defect Por Neuralgia Cyp17a1 Neurodevelopmental Disorders Comt , Sts neutropenia Ugt1a1 nevoid basal cell carcinoma syndrome Cyp17a1 nicotine dependence Comt obesity Akr1c1 , Comt , Cyp1b1 , Hsd11b1 , Hsd11b2 , Srd5a1 , Sts obsessive-compulsive disorder Comt Occupational Diseases Cyp1a1 Oligomenorrhea Cyp17a1 opiate dependence Comt OPTIC ATROPHY-ATAXIA-PERIPHERAL NEUROPATHY-GLOBAL DEVELOPMENTAL DELAY SYNDROME Fdxr oral cavity cancer Cyp1a1 oral squamous cell carcinoma Cyp1a1 oral submucous fibrosis Cyp3a9 osteoarthritis Akr1c1 osteoporosis Cyp17a1 , Cyp19a1 osteosarcoma Cyp3a2 ovarian cancer Comt , Cyp19a1 , Ugt1a1 ovarian carcinoma Cyp3a2 ovarian cyst Cyp17a1 ovarian disease Cyp19a1 Ovarian Neoplasms Cyp1b1 Pain Comt pancreatic cancer Cyp17a1 , Ugt1a7c pancreatitis Fdx1 panic disorder Comt Paranoid Disorders Comt , Hsd3b2 paraplegia Cyp19a1 , Cyp7b1 , Star parathyroid carcinoma Hsd11b1 , Hsd17b7 Parkinson's disease Cyp1a1 Parkinsonism Comt , Cyp1a1 pathological gambling Comt Pediatric Crohn's Disease Cyp3a9 Penis Agenesis Srd5a2 periodontitis Cyp1a1 peripheral vascular disease Cyp1a1 Perlman syndrome Ugt1a1 , Ugt1a2 , Ugt1a3 , Ugt1a5 , Ugt1a6 , Ugt1a9 Peters anomaly Cyp1b1 pheochromocytoma Comt PHGDH deficiency Hsd3b1 , Hsd3b2 placental insufficiency Cyp19a1 pleomorphic xanthoastrocytoma Akr1d1 , Cyp3a18 , Cyp3a2 , Cyp3a9 , Por pneumonia Cyp1a1 Polyarteritis Nodosa, Childhood-Onset Comt polycystic ovary syndrome Akr1c1 , Comt , Cyp17a1 , Cyp19a1 , Cyp1a1 , Hsd17b7 , Hsd3b1 , Hsd3b2 , Srd5a1 , Star Polyuria Ugt1a1 porphyria cutanea tarda Cyp1a1 Postmenopausal Osteoporosis Cyp19a1 pre-eclampsia Comt , Cyp11b2 , Cyp11b3 , Hsd11b1 Pregnancy Complications Hsd11b2 Prenatal Exposure Delayed Effects Cyp1a1 primary congenital glaucoma Cyp1b1 primary hyperaldosteronism Cyp11b1 , Cyp11b2 , Cyp11b3 primary immunodeficiency disease Comt primary open angle glaucoma Cyp1b1 primary ovarian insufficiency Cyp17a1 , Cyp19a1 , Por prostate cancer Comt , Cyp17a1 , Cyp1a1 , Srd5a1 , Srd5a2 prostate carcinoma in situ Cyp19a1 prostatic hypertrophy Srd5a1 , Srd5a2 Prostatic Neoplasms Comt , Cyp11b3 , Cyp17a1 , Cyp19a1 , Cyp1a1 , Cyp1b1 , Cyp3a18 , Cyp3a2 , Cyp3a9 , Cyp7b1 , Hsd17b1 , Hsd17b3 , Hsd3b1 , Hsd3b2 , Srd5a1 , Srd5a2 , Sult1e1 , Sult2b1 , Ugt2b1 prostatitis Cyp19a1 proteasome-associated autoinflammatory syndrome 1 Hsd17b8 protein-energy malnutrition Cyp19a1 pseudohermaphroditism Hsd17b3 Pseudovaginal Perineoscrotal Hypospadias Cyp1b1 , Srd5a2 psoriasis Comt , Cyp1a1 psoriatic arthritis Cyp1a1 pulmonary hypertension Cyp1a1 Pulmonary Hypertension, Hypoxia-Induced Cyp1a1 RASopathy Cyp1b1 reactive arthritis Cyp1a1 Recurrence Comt , Cyp19a1 renal cell carcinoma Comt , Cyp1a1 renal tubular acidosis Cyp11b2 Reperfusion Injury Cyp19a1 , Cyp3a9 , Sult1e1 rheumatoid arthritis Hsd11b1 , Sts schizophrenia Akr1c1 , Comt , Cyp11a1 , Cyp1a1 , Sts , Ugt1a2 Schizophrenia Spectrum and Other Psychotic Disorders Comt sciatic neuropathy Cyp11a1 , Cyp17a1 , Hsd3b1 Sepsis Cyp1a1 sexual health disorder Cyp17a1 Sexual Infantilism Cyp19a1 Sinus Tachycardia Cyp1a1 Sjogren's syndrome Cyp19a1 , Cyp1a1 small cell carcinoma Ugt1a1 spastic ataxia Cyp7b1 Spontaneous Abortions Cyp1a1 , Hsd17b1 squamous cell carcinoma Cyp1b1 Starvation Ugt1a1 status epilepticus Cyp11a1 , Hsd11b1 steatotic liver disease Cyp19a1 , Cyp1b1 , Cyp7b1 , Sts stomach cancer Cyp1a1 Stroke Cyp11b2 , Cyp11b3 Subarachnoid Hemorrhage Cyp3a2 systemic lupus erythematosus Cyp1a1 Temporomandibular Joint Disorders Comt thrombosis Cyp3a9 Tissue Adhesions Cyp19a1 Tobacco Use Disorder Comt Torsades de Pointes Cyp3a2 toxic encephalopathy Cyp3a9 type 1 diabetes mellitus Hsd11b2 , Ugt1a1 type 2 diabetes mellitus Cyp11a1 , Cyp11b2 , Cyp11b3 , Cyp1a1 , Cyp3a2 , Cyp3a23-3a1 , Hsd11b1 , Hsd11b2 , Hsd17b3 , Hsd3b1 , Srd5a1 , Star , Ugt1a1 , Ugt1a6 , Ugt1a7c uremia Comt ureteral obstruction Hsd11b2 urethral obstruction Cyp19a1 urinary bladder cancer Comt , Cyp17a1 , Cyp19a1 , Cyp1a1 , Cyp1b1 , Por velocardiofacial syndrome Comt Venous Thrombosis Comt Ventricular Remodeling Cyp1a1 VITAMIN D-DEPENDENT RICKETS, TYPE 3 Cyp3a2 vitiligo Comt Weight Gain Sts withdrawal disorder Comt X-linked ichthyosis Sts xanthinuria Srd5a2 xanthinuria type II Srd5a2