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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:sciatic neuropathy
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Accession:DOID:11446 term browser browse the term
Definition:Disease or damage involving the SCIATIC NERVE, which divides into the PERONEAL NERVE and TIBIAL NERVE (see also PERONEAL NEUROPATHIES and TIBIAL NEUROPATHY). Clinical manifestations may include SCIATICA or pain localized to the hip, PARESIS or PARALYSIS of posterior thigh muscles and muscles innervated by the peroneal and tibial nerves, and sensory loss involving the lateral and posterior thigh, posterior and lateral leg, and sole of the foot. The sciatic nerve may be affected by trauma; ISCHEMIA; COLLAGEN DISEASES; and other conditions. (From Adams et al., Principles of Neurology, 6th ed, p1363)
Synonyms:exact_synonym: Sciatic Nerve Disease;   Sciatic Nerve Diseases;   Sciatic Nerve Injuries;   Sciatic Nerve Injury;   Sciatic Nerve Neuralgia-Neuritides;   Sciatic Nerve Neuralgia-Neuritis;   Sciatic Nerve Palsies;   Sciatic Nerve Palsy;   Sciatic Neuritides;   Sciatic Neuritis;   Sciatic Neuropathies
 related_synonym: Sciatic Inflammatory Neuropathy
 primary_id: MESH:D020426
 alt_id: RDO:0006542
For additional species annotation, visit the Alliance of Genome Resources.

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sciatic neuropathy term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc8 ATP binding cassette subfamily C member 8 IEP protein:decreased expression:spinal cord RGD PMID:21907492 RGD:12791994 NCBI chr 1:102,110,708...102,191,287
Ensembl chr 1:102,110,708...102,191,287 		JBrowse link
G Abcc9 ATP binding cassette subfamily C member 9 IEP protein:decreased expression:spinal cord RGD PMID:21907492 RGD:12791994 NCBI chr 4:176,806,098...176,928,540
Ensembl chr 4:176,805,431...176,922,424 		JBrowse link
G Adrb2 adrenoceptor beta 2 treatment ISO RGD PMID:19912227 RGD:8548489 NCBI chr18:57,513,792...57,515,834
Ensembl chr18:57,513,793...57,515,834 		JBrowse link
G Agt angiotensinogen IDA RGD PMID:20886512 RGD:5129198 NCBI chr19:57,321,594...57,333,460
Ensembl chr19:57,321,640...57,333,433 		JBrowse link
G Akap12 A-kinase anchoring protein 12 IEP mRNA,protein:increased expression:spinal cord: RGD PMID:19937403 RGD:14348968 NCBI chr 1:40,816,130...40,906,582
Ensembl chr 1:40,816,107...40,906,581 		JBrowse link
G Amigo3 adhesion molecule with Ig like domain 3 IEP protein:increased expression:dorsal root ganglion (rat) RGD PMID:23613963 RGD:14390159 NCBI chr 8:116,830,773...116,832,299 JBrowse link
G Apoa1 apolipoprotein A1 IEP protein:increased expression:sciatic nerve: RGD PMID:2493483 RGD:7495790 NCBI chr 8:50,525,091...50,526,875
Ensembl chr 8:50,525,091...50,526,875 		JBrowse link
G Apoe apolipoprotein E IEP protein:increased expression:sciatic nerve: RGD PMID:2493483 RGD:7495790 NCBI chr 1:80,612,894...80,616,820
Ensembl chr 1:80,612,895...80,617,057 		JBrowse link
G Bdkrb1 bradykinin receptor B1 IMP RGD PMID:18182225 RGD:5129227 NCBI chr 6:129,437,423...129,441,553
Ensembl chr 6:129,438,158...129,440,574 		JBrowse link
G Bdkrb2 bradykinin receptor B2 IEP RGD PMID:18182225 RGD:5129227 NCBI chr 6:129,399,468...129,429,676
Ensembl chr 6:129,399,468...129,429,676 		JBrowse link
G Bdnf brain-derived neurotrophic factor treatment IEP
IDA		 protein:increased expression:dorsal root ganglion: RGD PMID:22309829, PMID:24388817 RGD:8657100, RGD:10059363 NCBI chr 3:100,768,637...100,819,216
Ensembl chr 3:100,768,637...100,819,210 		JBrowse link
G C3 complement C3 IEP protein:increased expression:sciatic nerve RGD PMID:18052971 RGD:5129535 NCBI chr 9:9,721,137...9,747,084
Ensembl chr 9:9,721,105...9,747,167 		JBrowse link
G Cacna1d calcium voltage-gated channel subunit alpha1 D IEP mRNA:decreased expression:spinal cord dorsal horn RGD PMID:16026470 RGD:6906922 NCBI chr16:6,110,294...6,405,022
Ensembl chr16:6,112,150...6,405,117 		JBrowse link
G Cacna1h calcium voltage-gated channel subunit alpha1 H IEP mRNA:increased expression:dorsal root ganglion RGD PMID:22972512 RGD:15042903 NCBI chr10:14,730,932...14,789,201
Ensembl chr10:14,730,941...14,788,617 		JBrowse link
G Cacna1i calcium voltage-gated channel subunit alpha1 I IEP mRNA:increased expression:dorsal root ganglion RGD PMID:22972512 RGD:15042903 NCBI chr 7:121,521,787...121,619,300
Ensembl chr 7:121,511,097...121,619,283 		JBrowse link
G Calca calcitonin-related polypeptide alpha ISO CTD Direct Evidence: therapeutic CTD PMID:19852068 NCBI chr 1:184,184,018...184,188,922
Ensembl chr 1:184,184,020...184,188,911 		JBrowse link
G Capn1 calpain 1 IEP protein:increased expression:skeletal muscle tissue of tibialis anterior RGD PMID:24745757 RGD:13792589 NCBI chr 1:221,346,081...221,370,965
Ensembl chr 1:221,346,066...221,370,322 		JBrowse link
G Capn2 calpain 2 IEP protein:increased expression:skeletal muscle tissue of tibialis anterior RGD PMID:24745757 RGD:13792589 NCBI chr13:100,878,649...100,928,811
Ensembl chr13:100,878,650...100,928,811 		JBrowse link
G Casp12 caspase 12 IDA mRNA, protein:increased expression:dorsal root ganglion RGD PMID:29659443 RGD:13782273 NCBI chr 8:2,658,892...2,686,160
Ensembl chr 8:2,659,865...2,686,160 		JBrowse link
G Casp3 caspase 3 IEP mRNA:increased expression:dorsal root ganglion RGD PMID:29659443 RGD:13782273 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204 		JBrowse link
G Casp7 caspase 7 IEP mRNA:increased expression:dorsal root ganglion RGD PMID:29659443 RGD:13782273 NCBI chr 1:277,190,557...277,242,779
Ensembl chr 1:277,190,964...277,242,774 		JBrowse link
G Casp8 caspase 8 IEP mRNA:increased expression:dorsal root ganglion RGD PMID:29659443 RGD:13782273 NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106 		JBrowse link
G Cat catalase IEP protein:decreased activity:sciatic nerve, spinal cord, dorsal root ganglion: RGD PMID:19675389 RGD:9479064 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058 		JBrowse link
G Cav1 caveolin 1 IEP protein:decreased expression:spinal cord, blood vessel RGD PMID:21795534 RGD:6784526 NCBI chr 4:44,597,123...44,630,206
Ensembl chr 4:44,597,123...44,630,200 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 IEP
ISO		 protein:increased expression:spinal cord dorsal horn, axon terminal (rat)
protein:increased expression:lumbar dorsal root ganglion (mouse)		 RGD PMID:19059387, PMID:22564672 RGD:2307005, RGD:8549487 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870 		JBrowse link
G Ccl5 C-C motif chemokine ligand 5 IEP mRNA:increased expression:sciatic nerve (rat) RGD PMID:19152028 RGD:4890004 NCBI chr10:70,739,764...70,744,303
Ensembl chr10:70,739,800...70,744,315 		JBrowse link
G Ccr2 C-C motif chemokine receptor 2 ISO RGD PMID:24907405 RGD:8661781
G Cdkn1b cyclin-dependent kinase inhibitor 1B IEP protein:decreased expression:sciatic nerve RGD PMID:21959983 RGD:10045367 NCBI chr 4:168,689,043...168,694,159
Ensembl chr 4:168,689,163...168,693,964 		JBrowse link
G Cnr2 cannabinoid receptor 2 treatment IDA RGD PMID:19345493 RGD:2316195 NCBI chr 5:154,242,010...154,268,126
Ensembl chr 5:154,260,062...154,268,126 		JBrowse link
G Crcp CGRP receptor component IEP RGD PMID:12895509 RGD:727768 NCBI chr12:30,125,237...30,160,857
Ensembl chr12:30,125,168...30,180,115 		JBrowse link
G Creb1 cAMP responsive element binding protein 1 IEP protein:increased phosphorylation:nucleus RGD PMID:19918364 RGD:10059430 NCBI chr 9:71,229,753...71,298,994
Ensembl chr 9:71,230,108...71,293,435 		JBrowse link
G Crh corticotropin releasing hormone IEP mRNA:increased expression:central nucleus of amygdala, bed nucleus of stria terminalis (rat) RGD PMID:21684787 RGD:5490542 NCBI chr 2:104,459,999...104,461,863
Ensembl chr 2:104,459,999...104,461,863 		JBrowse link
G Cx3cr1 C-X3-C motif chemokine receptor 1 treatment ISO
IEP		 RGD PMID:20524966, PMID:15341587, PMID:20921832 RGD:9354422, RGD:1358720, RGD:9491396 NCBI chr 8:128,740,756...128,754,514
Ensembl chr 8:128,740,756...128,754,514 		JBrowse link
G Cyp11a1 cytochrome P450, family 11, subfamily a, polypeptide 1 IEP protein:increased expression:spinal cord dorsal horn (rat) RGD PMID:16632873 RGD:4889134 NCBI chr 8:62,798,317...62,809,848
Ensembl chr 8:62,779,875...62,809,893 		JBrowse link
G Cyp17a1 cytochrome P450, family 17, subfamily a, polypeptide 1 IEP mRNA:decreased expression:spinal cord (rat) RGD PMID:17720801 RGD:4889112 NCBI chr 1:266,422,127...266,429,947
Ensembl chr 1:266,422,132...266,428,239 		JBrowse link
G Dbn1 drebrin 1 IEP protein:increased expression:neuron: RGD PMID:11578820 RGD:10398813 NCBI chr17:9,679,511...9,693,878
Ensembl chr17:9,679,628...9,693,820 		JBrowse link
G Dnmt3a DNA methyltransferase 3 alpha ISO protein:increased expression:brain: RGD PMID:22031875 RGD:9589072 NCBI chr 6:28,205,375...28,346,052
Ensembl chr 6:28,235,695...28,340,577 		JBrowse link
G Elavl4 ELAV like RNA binding protein 4 IEP RGD PMID:12957493 RGD:1579851 NCBI chr 5:130,001,387...130,144,557
Ensembl chr 5:130,001,372...130,085,838 		JBrowse link
G Fas Fas cell surface death receptor IEP RGD PMID:29970988 RGD:13792563 NCBI chr 1:252,589,785...252,624,790
Ensembl chr 1:252,589,785...252,624,790 		JBrowse link
G Fgfr1 Fibroblast growth factor receptor 1 IEP mRNA:increased expression:neuron: RGD PMID:8971765 RGD:10402092 NCBI chr16:71,265,390...71,319,046
Ensembl chr16:71,266,248...71,319,449 		JBrowse link
G Fubp1 far upstream element binding protein 1 IEP RGD PMID:23939805 RGD:13673880 NCBI chr 2:257,425,676...257,452,745
Ensembl chr 2:257,425,679...257,449,568 		JBrowse link
G Gc GC, vitamin D binding protein ISO protein:increased expression:nerve RGD PMID:15509515 RGD:2316214 NCBI chr14:20,267,023...20,302,577
Ensembl chr14:20,266,891...20,302,581 		JBrowse link
G Gdnf glial cell derived neurotrophic factor IEP mRNA:increased expression:sciatic nerve RGD PMID:10852218 RGD:6218977 NCBI chr 2:56,884,181...56,912,964
Ensembl chr 2:56,887,987...56,910,238 		JBrowse link
G Gfra1 GDNF family receptor alpha 1 IEP protein:increased expression:spinal cord dorsal horn RGD PMID:20533358 RGD:6218963 NCBI chr 1:279,203,046...279,572,789 JBrowse link
G Gfra3 GDNF family receptor alpha 3 IEP mRNA:increased expression:sciatic nerve RGD PMID:10852218 RGD:6218977 NCBI chr18:27,491,860...27,520,133
Ensembl chr18:27,491,845...27,520,295 		JBrowse link
G Grin1 glutamate ionotropic receptor NMDA type subunit 1 IEP RGD PMID:26656067 RGD:13792690 NCBI chr 3:2,507,745...2,534,664
Ensembl chr 3:2,506,896...2,534,663 		JBrowse link
G Grin2b glutamate ionotropic receptor NMDA type subunit 2B IEP RGD PMID:26656067 RGD:13792690 NCBI chr 4:169,541,620...170,000,216
Ensembl chr 4:169,560,387...169,999,873 		JBrowse link
G Gsk3b glycogen synthase kinase 3 beta IDA RGD PMID:27125978 RGD:13792740 NCBI chr11:65,060,884...65,208,842
Ensembl chr11:65,066,235...65,209,268 		JBrowse link
G Hgf hepatocyte growth factor treatment ISO RGD PMID:18941443 RGD:8548631 NCBI chr 4:15,435,460...15,505,377
Ensembl chr 4:15,433,295...15,505,362 		JBrowse link
G Hmgb1 high mobility group box 1 treatment IMP RGD PMID:23991202 RGD:10402062 NCBI chr12:7,082,529...7,090,246
Ensembl chr16:37,500,017...37,502,237 		JBrowse link
G Hmox1 heme oxygenase 1 treatment IDA RGD PMID:23224421 RGD:10755722 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456 		JBrowse link
G Hrh3 histamine receptor H3 IDA RGD PMID:17350523 RGD:1626418 NCBI chr 3:175,474,310...175,479,395
Ensembl chr 3:175,473,078...175,479,395 		JBrowse link
G Hsd3b1 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 IEP mRNA:increased expression:fourth lumbar dorsal root ganglion (rat) RGD PMID:12648755 RGD:632873
G Icam1 intercellular adhesion molecule 1 IEP RGD PMID:20546684 RGD:8547739 NCBI chr 8:22,035,287...22,047,049
Ensembl chr 8:22,035,256...22,047,059 		JBrowse link
G Il10 interleukin 10 treatment IDA
IEP		 associated with Constriction, Pathologic RGD PMID:22889616, PMID:22173123 RGD:7364826, RGD:7364836 NCBI chr13:47,738,933...47,743,392
Ensembl chr13:47,739,526...47,743,392 		JBrowse link
G Il1b interleukin 1 beta treatment IEP RGD PMID:22173123 RGD:7364836 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726 		JBrowse link
G Il1rn interleukin 1 receptor antagonist ISO rat model treated with human protein RGD PMID:12574433 RGD:7175064 NCBI chr 3:1,449,778...1,468,624
Ensembl chr 3:1,452,644...1,468,614 		JBrowse link
G Il6 interleukin 6 IEP protein:increased expression:dorsal root ganglion RGD PMID:20519054 RGD:5128675 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807 		JBrowse link
G Il6r interleukin 6 receptor IEP protein:increased expression:dorsal root ganglion RGD PMID:20519054 RGD:5128675 NCBI chr 2:189,196,180...189,255,987
Ensembl chr 2:189,205,701...189,254,628 		JBrowse link
G Jam3 junctional adhesion molecule 3 IEP RGD PMID:22950044 RGD:7488944 NCBI chr 8:28,147,110...28,208,466
Ensembl chr 8:28,147,111...28,208,466 		JBrowse link
G Kars lysyl-tRNA synthetase IEP mRNA,protein:decreased expression:dorsal root ganglion: RGD PMID:25467976 RGD:12910554 NCBI chr19:44,212,205...44,231,209
Ensembl chr19:44,212,206...44,231,157 		JBrowse link
G Kcnc4 potassium voltage-gated channel subfamily C member 4 IEP RGD PMID:17855600 RGD:10411908 NCBI chr 2:210,220,908...210,241,447
Ensembl chr 2:210,220,908...210,241,455 		JBrowse link
G Kcnj11 potassium inwardly-rectifying channel, subfamily J, member 11 IEP mRNA:increased expression:dorsal root ganglion RGD PMID:17108688 RGD:7297043 NCBI chr 1:102,103,093...102,107,134
Ensembl chr 1:102,103,094...102,106,127 		JBrowse link
G Kcnj8 potassium inwardly-rectifying channel, subfamily J, member 8 IEP protein:decreased expression:spinal cord RGD PMID:21907492 RGD:12791994 NCBI chr 4:176,783,287...176,789,143
Ensembl chr 4:176,782,498...176,789,304 		JBrowse link
G Lamp2 lysosomal-associated membrane protein 2 treatment IEP RGD PMID:30015858 RGD:13703060 NCBI chr  X:124,722,628...124,766,079
Ensembl chr  X:124,722,628...124,766,044 		JBrowse link
G Lrp1 LDL receptor related protein 1 treatment IEP
ISO		 RGD PMID:26656067, PMID:18060043 RGD:13792690, RGD:13800561 NCBI chr 7:70,846,313...70,927,028
Ensembl chr 7:70,846,344...70,926,903 		JBrowse link
G Mag myelin-associated glycoprotein treatment IDA RGD PMID:17705198 RGD:9685295 NCBI chr 1:89,345,325...89,360,905
Ensembl chr 1:89,345,429...89,360,733 		JBrowse link
G Map2 microtubule-associated protein 2 IEP protein:decrease expression:dorsal root ganglion RGD PMID:21933624 RGD:6483083 NCBI chr 9:73,204,753...73,462,965
Ensembl chr 9:73,319,710...73,462,972 		JBrowse link
G Mc4r melanocortin 4 receptor IEP protein:increased expression:dorsal root ganglia (rat) RGD PMID:21985621 RGD:6484557 NCBI chr18:62,612,838...62,614,725
Ensembl chr18:62,612,838...62,614,725 		JBrowse link
G Mir381 microRNA 381 IEP RNA:decreased expression:spinal cord RGD PMID:30142543 RGD:13838658 NCBI chr 6:133,876,615...133,876,675
Ensembl chr 6:133,876,586...133,876,693 		JBrowse link
G Mir96 microRNA 96 IEP RNA:decreased expression:dorsal root ganglion: RGD PMID:24234845 RGD:11553932 NCBI chr 4:57,463,366...57,463,471
Ensembl chr 4:57,463,366...57,463,471 		JBrowse link
G Mmp9 matrix metallopeptidase 9 treatment IEP RGD PMID:25172308 RGD:13207330 NCBI chr 3:161,413,410...161,421,473
Ensembl chr 3:161,413,298...161,421,520 		JBrowse link
G Mpz myelin protein zero treatment IEP RGD PMID:23545781 RGD:9685778 NCBI chr13:89,524,204...89,530,070
Ensembl chr13:89,524,329...89,530,068 		JBrowse link
G Mtor mechanistic target of rapamycin kinase IMP RGD PMID:20452291 RGD:10041037 NCBI chr 5:165,263,813...165,373,967
Ensembl chr 5:165,263,800...165,373,967 		JBrowse link
G Myh4 myosin heavy chain 4 treatment IEP RGD PMID:14973145 RGD:9686059 NCBI chr10:53,778,456...53,801,605
Ensembl chr10:53,713,938...53,848,347 		JBrowse link
G Nefh neurofilament heavy treatment IEP RGD PMID:3135913, PMID:12445968 RGD:9693730, RGD:9743941 NCBI chr14:85,181,572...85,191,557
Ensembl chr14:85,181,572...85,191,557 		JBrowse link
G Nefl neurofilament light IEP associated with Diabetes Mellitus, Type 1 RGD PMID:12445968, PMID:3135913, PMID:12638730 RGD:9743941, RGD:9693730, RGD:9743948 NCBI chr15:44,799,378...44,803,251
Ensembl chr15:44,799,334...44,804,574 		JBrowse link
G Nefm neurofilament medium treatment IEP associated with Diabetes Mellitus, Type 1 RGD PMID:12445968, PMID:3135913, PMID:12638730 RGD:9743941, RGD:9693730, RGD:9743948 NCBI chr15:44,855,307...44,860,604
Ensembl chr15:44,855,310...44,860,604 		JBrowse link
G Nf1 neurofibromin 1 IEP protein:increased expression:sciatic nerve: RGD PMID:8847098 RGD:12790590 NCBI chr10:66,732,460...66,928,706
Ensembl chr10:66,690,133...66,928,903 		JBrowse link
G Nfkbia NFKB inhibitor alpha treatment IDA RGD PMID:18938092 RGD:10413869 NCBI chr 6:76,267,227...76,270,457
Ensembl chr 6:76,267,228...76,270,457 		JBrowse link
G Ngf nerve growth factor treatment ISO RGD PMID:22776032 RGD:7242913 NCBI chr 2:204,886,158...204,939,523
Ensembl chr 2:204,886,202...204,940,453 		JBrowse link
G Ngfr nerve growth factor receptor ISO
IEP		 RGD PMID:17576803, PMID:23138653 RGD:5144067, RGD:10414078 NCBI chr10:83,389,828...83,408,061
Ensembl chr10:83,389,847...83,408,061 		JBrowse link
G Nlgn2 neuroligin 2 IEP mRNA:decreased expression:sciatic nerve RGD PMID:17492651 RGD:9831149 NCBI chr10:56,431,586...56,444,847
Ensembl chr10:56,431,573...56,444,847 		JBrowse link
G Nlgn3 neuroligin 3 IEP mRNA:decreased expression:sciatic nerve RGD PMID:17492651 RGD:9831149 NCBI chr  X:71,199,390...71,227,460
Ensembl chr  X:71,199,491...71,222,732 		JBrowse link
G Nmnat1 nicotinamide nucleotide adenylyltransferase 1 IEP mRNA:increased expression:dorsal root ganglion: RGD PMID:16914673 RGD:13781948 NCBI chr 5:166,409,460...166,430,291
Ensembl chr 5:166,409,461...166,430,254 		JBrowse link
G Nos1ap nitric oxide synthase 1 adaptor protein IEP mRNA:increased expression:sciatic nerve RGD PMID:17768032 RGD:7327169 NCBI chr13:88,653,123...88,943,976 JBrowse link
G Nrg1 neuregulin 1 treatment IMP RGD PMID:20957456 RGD:10449012 NCBI chr16:62,969,573...64,065,063
Ensembl chr16:63,837,216...64,057,434 		JBrowse link
G Nts neurotensin IEP RGD PMID:8518953 RGD:9743903 NCBI chr 7:44,111,594...44,120,998
Ensembl chr 7:44,111,151...44,121,130 		JBrowse link
G Oprl1 opioid related nociceptin receptor 1 IEP mRNA:increased expression:brain: RGD PMID:15862535 RGD:9835022 NCBI chr 3:177,223,779...177,231,663
Ensembl chr 3:177,225,737...177,231,663 		JBrowse link
G Pcna proliferating cell nuclear antigen IEP RGD PMID:23014974 RGD:10448976 NCBI chr 3:124,880,698...124,884,570
Ensembl chr 3:124,880,698...124,884,570 		JBrowse link
G Pcsk5 proprotein convertase subtilisin/kexin type 5 IEP mRNA,protein:increased expression:nerve: RGD PMID:9729404 RGD:11556234 NCBI chr 1:236,031,988...236,313,858
Ensembl chr 1:236,031,988...236,313,858 		JBrowse link
G Pdgfra platelet derived growth factor receptor alpha IEP RGD PMID:19909480 RGD:11080976 NCBI chr14:35,527,926...35,581,130
Ensembl chr14:35,527,927...35,581,031 		JBrowse link
G Pdgfrb platelet derived growth factor receptor beta IEP RGD PMID:19909480 RGD:11080976 NCBI chr18:56,364,586...56,406,381
Ensembl chr18:56,364,620...56,406,381 		JBrowse link
G Plat plasminogen activator, tissue type IEP RGD PMID:18716863 RGD:6483827 NCBI chr16:74,098,263...74,122,897
Ensembl chr16:74,098,260...74,122,889 		JBrowse link
G Plau plasminogen activator, urokinase treatment IEP
IDA		 mRNA:increased expression:sciatic nerve (rat) RGD PMID:18716863, PMID:21151668 RGD:6483827, RGD:7241585 NCBI chr15:3,644,296...3,650,765
Ensembl chr15:3,644,769...3,650,819 		JBrowse link
G Pmp22 peripheral myelin protein 22 IEP RGD PMID:1556154 RGD:1358785 NCBI chr10:49,538,588...49,568,583
Ensembl chr10:49,538,588...49,568,583 		JBrowse link
G Ppargc1a PPARG coactivator 1 alpha IDA associated with Diabetes Mellitus, Experimental RGD PMID:22996345 RGD:7242051 NCBI chr14:63,095,291...63,190,688
Ensembl chr14:63,095,720...63,187,009 		JBrowse link
G Ptafr platelet-activating factor receptor IEP mRNA:increased expression:spinal cord, microglia (rat) RGD PMID:22296727 RGD:9999207 NCBI chr 5:150,746,284...150,775,675
Ensembl chr 5:150,754,021...150,775,672 		JBrowse link
G Ptn pleiotrophin IEP mRNA:altered expression:dorsal root ganglia (rat) RGD PMID:18365878 RGD:9831453 NCBI chr 4:64,239,156...64,330,996
Ensembl chr 4:64,239,158...64,330,996 		JBrowse link
G Qars1 glutaminyl-tRNA synthetase 1 IEP mRNA,protein:decreased expression:dorsal root ganglion: RGD PMID:25467976 RGD:12910554 NCBI chr 8:117,297,670...117,305,708
Ensembl chr 8:117,297,670...117,305,702 		JBrowse link
G Ran RAN, member RAS oncogene family IDA RGD PMID:18667152 RGD:9835000 NCBI chr12:31,319,556...31,324,105
Ensembl chr12:31,320,624...31,323,810 		JBrowse link
G Ranbp1 RAN binding protein 1 IEP protein:increased expression:sciatic nerve (rat) RGD PMID:18667152 RGD:9835000 NCBI chr11:86,890,585...86,898,818
Ensembl chr11:86,890,585...86,898,818 		JBrowse link
G Rangap1 RAN GTPase activating protein 1 IEP protein:increased expression:sciatic nerve, axon, cytoplasm (rat) RGD PMID:18667152 RGD:9835000 NCBI chr 7:122,939,266...122,967,178
Ensembl chr 7:122,940,376...122,967,178 		JBrowse link
G Rara retinoic acid receptor, alpha ISO CTD Direct Evidence: marker/mechanism CTD PMID:16782282 NCBI chr10:86,838,819...86,884,224
Ensembl chr10:86,860,685...86,884,210 		JBrowse link
G Rarb retinoic acid receptor, beta ISO CTD Direct Evidence: marker/mechanism CTD PMID:16782282 NCBI chr15:9,915,223...10,262,599
Ensembl chr15:10,120,206...10,262,599 		JBrowse link
G Rchy1 ring finger and CHY zinc finger domain containing 1 IEP protein:increased expression:sciatic nerve RGD PMID:21959983 RGD:10045367 NCBI chr14:17,615,968...17,631,715
Ensembl chr14:17,615,968...17,631,714 		JBrowse link
G Reg3b regenerating family member 3 beta IEP mRNA:increased expression:lumbar spinal cord, dorsal root ganglia (rat) RGD PMID:21561713 RGD:9831430 NCBI chr 4:109,467,272...109,470,510
Ensembl chr 4:109,467,272...109,470,510 		JBrowse link
G Rgma repulsive guidance molecule BMP co-receptor a IEP RGD PMID:16863689 RGD:9850145 NCBI chr 1:134,699,053...134,742,512
Ensembl chr 1:134,699,299...134,742,514 		JBrowse link
G Rpsa ribosomal protein SA IEP RGD PMID:19196078 RGD:11041651 NCBI chr 8:128,806,053...128,809,987
Ensembl chr 8:128,806,129...128,809,986 		JBrowse link
G Runx1 RUNX family transcription factor 1 ISO mRNA:decreased expression:dorsal root ganglion RGD PMID:22216140 RGD:6482827 NCBI chr11:32,765,147...33,003,061
Ensembl chr11:32,769,165...33,003,021 		JBrowse link
G Rxra retinoid X receptor alpha ISO CTD Direct Evidence: marker/mechanism CTD PMID:16782282 NCBI chr 3:6,272,560...6,295,354
Ensembl chr 3:6,211,789...6,295,908 		JBrowse link
G Scn10a sodium voltage-gated channel alpha subunit 10 IMP RGD PMID:21965668 RGD:6484251 NCBI chr 8:128,298,593...128,416,896
Ensembl chr 8:128,298,594...128,416,650 		JBrowse link
G Serpine1 serpin family E member 1 treatment IDA RGD PMID:25967608 RGD:11075075 NCBI chr12:22,641,104...22,651,482
Ensembl chr12:22,641,104...22,651,482 		JBrowse link
G Serpinf1 serpin family F member 1 treatment ISO human protein in a mouse model RGD PMID:10441236 RGD:8554886 NCBI chr10:62,241,750...62,254,145
Ensembl chr10:62,241,756...62,254,287 		JBrowse link
G Slc17a7 solute carrier family 17 member 7 IEP protein:decreased expression:nucleus accumbens RGD PMID:23835161 RGD:9999206 NCBI chr 1:101,161,265...101,172,292
Ensembl chr 1:101,161,252...101,173,174 		JBrowse link
G Slc17a8 solute carrier family 17 member 8 IEP protein:decreased expression:nucleus accumbens RGD PMID:23835161 RGD:9999206 NCBI chr 7:30,215,231...30,274,993
Ensembl chr 7:30,216,104...30,274,984 		JBrowse link
G Snw1 SNW domain containing 1 IDA protein:increased expression:sciatic nerve (rat) RGD PMID:23389663 RGD:11035242 NCBI chr 6:111,483,698...111,507,782
Ensembl chr 6:111,483,703...111,507,782 		JBrowse link
G Sod1 superoxide dismutase 1 severity
treatment		 ISO
IDA		 human gene in a rat model;DNA:missense mutation:cds:p.G93A (human) RGD PMID:21489258, PMID:15707675 RGD:8655638, RGD:8655979 NCBI chr11:30,363,282...30,368,858
Ensembl chr11:30,363,280...30,368,862 		JBrowse link
G Tlr2 toll-like receptor 2 ISO mRNA:increased expression:sciatic nerve: RGD PMID:21125644 RGD:8553062 NCBI chr 2:182,840,171...182,846,061
Ensembl chr 2:182,840,727...182,846,061 		JBrowse link
G Tlr4 toll-like receptor 4 IEP
ISO
IMP		 mRNA,protein:increased expression:spinal cord:
mRNA:increased expression:spinal cord:		 RGD PMID:22173123, PMID:18615568, PMID:22173123 RGD:7364836, RGD:7815041, RGD:7364836 NCBI chr 5:82,587,424...82,601,056
Ensembl chr 5:82,587,420...82,601,052 		JBrowse link
G Tnf tumor necrosis factor treatment IEP RGD PMID:22173123 RGD:7364836 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000 		JBrowse link
G Tnfrsf1a TNF receptor superfamily member 1A ISO
IEP		 protein:increased expression:dorsal root ganglia (rat) RGD PMID:9582261, PMID:11240015 RGD:5130898, RGD:5130963 NCBI chr 4:157,864,905...157,877,634
Ensembl chr 4:157,864,969...157,877,633 		JBrowse link
G Tnfrsf1b TNF receptor superfamily member 1B IEP protein:increased expression:dorsal root ganglia (rat) RGD PMID:11240015 RGD:5130963 NCBI chr 5:163,136,390...163,167,299
Ensembl chr 5:163,136,390...163,167,299 		JBrowse link
Sciatica term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bloc1s2 biogenesis of lysosomal organelles complex-1, subunit 2 IMP RGD PMID:16176350 RGD:2302154 NCBI chr 1:263,913,901...263,920,989
Ensembl chr 1:263,913,854...263,920,962 		JBrowse link
G Tnfrsf1b TNF receptor superfamily member 1B treatment IDA RGD PMID:22425187 RGD:7245944 NCBI chr 5:163,136,390...163,167,299
Ensembl chr 5:163,136,390...163,167,299 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 16122
    disease of anatomical entity 15369
      nervous system disease 10977
        peripheral nervous system disease 2430
          mononeuropathy 140
            mononeuritis 139
              mononeuritis of lower limb 129
                lesion of sciatic nerve 129
                  sciatic neuropathy 126
                    Piriformis Muscle Syndrome + 0
                    Sciatica + 2
Path 2
Term Annotations click to browse term
  disease 16122
    disease of anatomical entity 15369
      nervous system disease 10977
        peripheral nervous system disease 2430
          neuropathy 2245
            mononeuropathy 140
              mononeuritis 139
                mononeuritis of lower limb 129
                  lesion of sciatic nerve 129
                    sciatic neuropathy 126
                      Piriformis Muscle Syndrome + 0
                      Sciatica + 2
paths to the root