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RGD uses the Human Disease Ontology (DO, for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.

Term:Cardiac Fibrosis
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Accession:DOID:9003139 term browser browse the term
Definition:A pathological condition where fibrous connective tissue invades the heart, usually as a consequence of inflammation or other injury.
Synonyms:exact_synonym: heart fibrosis
 related_synonym: atrial fibrosis;   myocardial fibrosis
 primary_id: RDO:9000045
For additional species annotation, visit the Alliance of Genome Resources.

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Cardiac Fibrosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ace2 angiotensin I converting enzyme 2 treatment IEP associated with Hypertension RGD PMID:21148624 RGD:9685434 NCBI chr  X:32,050,734...32,095,860
Ensembl chr  X:32,049,931...32,096,016
JBrowse link
G Ager advanced glycosylation end product-specific receptor treatment IEP associated with Diabetes Mellitus, Experimental; protein:increased expression:cardiac atrium (rat) RGD PMID:21802905, PMID:24630381 RGD:7245957, RGD:8696003 NCBI chr20:4,363,152...4,366,079
Ensembl chr20:4,363,152...4,366,079
JBrowse link
G Col1a1 collagen type I alpha 1 chain treatment IEP
associated with Hypertension;mRNA:increased expression:heart RGD PMID:21769867, PMID:19019833 RGD:5688337, RGD:8552780 NCBI chr10:82,745,801...82,762,790
Ensembl chr10:82,745,801...82,762,789
JBrowse link
G Csf3 colony stimulating factor 3 ISO associated with Myocardial Infarction; RGD PMID:18676396 RGD:11039480 NCBI chr10:86,616,785...86,619,160
Ensembl chr10:86,616,785...86,619,157
JBrowse link
G Dmd dystrophin IMP RGD PMID:25310701 RGD:12880034 NCBI chr  X:51,149,358...53,519,271
Ensembl chr  X:51,286,737...53,519,259
JBrowse link
G Dmdem1Ang dystrophin; TALEN-induced mutant1, Ang IMP RGD PMID:25310701 RGD:12880034
G Edn1 endothelin 1 treatment IDA RGD PMID:11430925 RGD:8662299 NCBI chr17:22,136,814...22,143,745
Ensembl chr17:22,137,324...22,143,324
JBrowse link
G F3 coagulation factor III, tissue factor ISO RGD PMID:12426405 RGD:11341691 NCBI chr 2:225,310,686...225,322,281
Ensembl chr 2:225,310,624...225,322,272
JBrowse link
G Fbn1 fibrillin 1 IEP associated with Hypertension;protein:increased expression:myocardium RGD PMID:15849235 RGD:1601147 NCBI chr 3:117,569,708...117,766,160
Ensembl chr 3:117,569,697...117,766,120
JBrowse link
G Fn1 fibronectin 1 IEP mRNA, protein:increased expression:heart: RGD PMID:23383330 RGD:10402158 NCBI chr 9:78,900,111...78,969,018
Ensembl chr 9:78,900,103...78,969,078
JBrowse link
G Ghrl ghrelin and obestatin prepropeptide disease_progression
mRNA,protein:increased expression:plasma,myocardia: RGD PMID:16626506, PMID:16626506 RGD:12907503, RGD:12907503 NCBI chr 4:145,674,157...145,678,066
Ensembl chr 4:145,674,157...145,678,066
JBrowse link
G Ghsr growth hormone secretagogue receptor IEP mRNA,protein:increased expression,increased activity:myocardia: RGD PMID:16626506 RGD:12907503 NCBI chr 2:113,065,953...113,071,265
Ensembl chr 2:113,066,885...113,070,261
JBrowse link
G Gja1 gap junction protein, alpha 1 IEP protein:decreased expression:myocardium RGD PMID:23906405 RGD:8662459 NCBI chr20:37,876,650...37,889,097
Ensembl chr20:37,876,650...37,889,089
JBrowse link
G Hrc histidine rich calcium binding protein severity ISO associated with Heart Failure RGD PMID:22952658 RGD:9685495 NCBI chr 1:101,324,788...101,328,391
Ensembl chr 1:101,324,652...101,328,435
JBrowse link
G Mfn2 mitofusin 2 IEP protein:decreased expression:heart (rat) RGD PMID:26692091 RGD:11557238 NCBI chr 5:164,684,244...164,715,414
Ensembl chr 5:164,684,509...164,714,145
JBrowse link
G Mir221 microRNA 221 severity ISO associated with dilated cardiomyopathy; RGD PMID:29255073 RGD:18337269 NCBI chr  X:3,684,480...3,684,588
Ensembl chr  X:3,684,480...3,684,588
JBrowse link
G Mir223 microRNA 223 treatment IMP associated with acute myocardial infarction; RGD PMID:29689569 RGD:25823140 NCBI chr  X:65,367,812...65,367,921
Ensembl chr  X:65,367,812...65,367,921
JBrowse link
G Mir433 microRNA 433 treatment ISO associated with myocardial infarction RGD PMID:27698941, PMID:27698941 RGD:14700802, RGD:14700802 NCBI chr 6:133,712,334...133,712,426
Ensembl chr 6:133,712,334...133,712,426
JBrowse link
G Mmp7 matrix metallopeptidase 7 IEP associated with Heart Failure RGD PMID:12875773 RGD:9685341 NCBI chr 8:5,893,253...5,900,965
Ensembl chr 8:5,893,249...5,901,049
JBrowse link
G Mmp9 matrix metallopeptidase 9 ISO
associated with Cardiomegaly;mRNA:increased expression:heart
associated with Arthritis, Experimental
RGD PMID:23144938, PMID:23905389 RGD:13204817, RGD:13204857 NCBI chr 3:161,413,410...161,421,473
Ensembl chr 3:161,413,298...161,421,520
JBrowse link
G Nfkbia NFKB inhibitor alpha treatment IEP associated with Hypertension RGD PMID:20231522 RGD:10413875 NCBI chr 6:76,267,227...76,270,457
Ensembl chr 6:76,267,228...76,270,457
JBrowse link
G Nod1 nucleotide-binding oligomerization domain containing 1 ISO RGD PMID:23028889 RGD:9831166 NCBI chr 4:85,123,965...85,175,206
Ensembl chr 4:85,123,960...85,174,951
JBrowse link
G Pak1 p21 (RAC1) activated kinase 1 ISO RGD PMID:22082674 RGD:11533929 NCBI chr 1:162,768,156...162,883,356
Ensembl chr 1:162,768,156...162,883,355
JBrowse link
G Plekha7 pleckstrin homology domain containing A7 IMP RGD PMID:25136115 RGD:11079199 NCBI chr 1:185,427,600...185,493,985
Ensembl chr 1:185,356,975...185,538,694
JBrowse link
G Plekha7em4Mcwi pleckstrin homology domain containing, family A member 7; zinc finger nuclease induced mutant 4, Medical College of Wisconsin IMP RGD PMID:25136115 RGD:11079199
G Serpine1 serpin family E member 1 treatment IEP
associated with Hypertension;mRNA, protein:increased expression:heart left ventricle (rat)
associated with Metabolic Syndrome X
RGD PMID:11961044, PMID:15604340 RGD:8547914, RGD:8547923 NCBI chr12:22,641,104...22,651,482
Ensembl chr12:22,641,104...22,651,482
JBrowse link
G Tgfb1 transforming growth factor, beta 1 ISO
protein:increased expression:heart: RGD PMID:22134166, PMID:27108788 RGD:11073617, RGD:11073667 NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  disease 16023
    Pathological Conditions, Signs and Symptoms 8754
      Pathologic Processes 6130
        Fibrosis 1419
          Cardiac Fibrosis 31
paths to the root


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.