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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.

Term:Metabolic Side Effects of Drugs and Substances
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Accession:DOID:9007639 term browser browse the term
Definition:Specific effects of drugs and substances on metabolic pathways such as those occurring through the CYTOCHROME P-450 ENZYME SYSTEM. These include effects that often result in DRUG INTERACTIONS; FOOD-DRUG INTERACTIONS; and HERB-DRUG INTERACTIONS.
Synonyms:exact_synonym: Drug Effects on Metabolism;   Metabolic Side Effects of Drugs;   Metabolic Side Effects of Substances;   Substance Effects on Metabolism
 primary_id: MESH:D065606;   RDO:0015974



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Metabolic Side Effects of Drugs and Substances term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 IEP Associated with incense smoke exposure;mRNA:increased expression:heart (rat) RGD PMID:25687613 RGD:401900684 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 treatment IEP associated with nitrate tolerance
associated with nitrate tolerance; protein:decreased expression:thoracic aorta (rat)
Associated with incense smoke exposure;mRNA:increased expression:heart (rat)
RGD PMID:16520233 PMID:12688525 PMID:25687613 RGD:401900296, RGD:401900656, RGD:401900684 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 susceptibility ISO DNA:SNP: :CYP2B6*6 (516G>T,785A>G) ((human) RGD PMID:27289271 RGD:401901173 NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143
JBrowse link
G Myh7 myosin heavy chain 7 IEP Associated with incense smoke exposure;mRNA:increased expression:heart (rat) RGD PMID:25687613 RGD:401900684 NCBI chr15:28,446,550...28,469,888
Ensembl chr15:28,446,550...28,468,217
JBrowse link
G Nppa natriuretic peptide A IEP Associated with incense smoke exposure;mRNA:increased expression:heart (rat) RGD PMID:25687613 RGD:401900684 NCBI chr 5:158,429,042...158,430,351
Ensembl chr 5:158,429,042...158,430,351
JBrowse link
G Nppb natriuretic peptide B IEP Associated with incense smoke exposure;mRNA:increased expression:heart (rat) RGD PMID:25687613 RGD:401900684 NCBI chr 5:158,416,813...158,418,175
Ensembl chr 5:158,416,866...158,418,168
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  disease 21128
    Chemically-Induced Disorders 1385
      Drug-Related Side Effects and Adverse Reactions 660
        Metabolic Side Effects of Drugs and Substances 6
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