RGD DISEASE ONTOLOGY - ANNOTATIONS
RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term: Drug Eruptions
Accession: DOID:9005236
browse the term
Definition: Adverse cutaneous reactions caused by ingestion, parenteral use, or local application of a drug. These may assume various morphologic patterns and produce various types of lesions.
Synonyms: exact_synonym: Dermatitis Medicamentosa; Dermatitis, Adverse Drug Reaction; Drug Eruption; Maculopapular Drug Eruption; Maculopapular Drug Eruptions; Maculopapular Exanthem; Maculopapular Exanthems; Morbilliform Drug Reaction; Morbilliform Drug Reactions; Morbilliform Exanthem; Morbilliform Exanthems
primary_id: MESH:D003875 ; RDO:0005346
For additional species annotation, visit the
Alliance of Genome Resources .
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Alox5
arachidonate 5-lipoxygenase
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:16502481
NCBI chr 4:148,398,004...148,446,308
Ensembl chr 4:148,398,892...148,446,303
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Apoa1
apolipoprotein A1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:21055120
NCBI chr 8:50,525,091...50,526,875
Ensembl chr 8:50,525,091...50,526,875
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Apoc2
apolipoprotein C2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:21055120
NCBI chr 1:80,589,023...80,593,991
Ensembl chr 1:80,589,023...80,594,136
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Apoc3
apolipoprotein C3
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:21055120
NCBI chr 8:50,529,318...50,531,498
Ensembl chr 8:50,529,318...50,531,498
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Bdnf
brain-derived neurotrophic factor
ISO
mRNA:increased expression:lymph node, ear:
RGD
PMID:19904815
RGD:8657071
NCBI chr 3:100,768,637...100,819,216
Ensembl chr 3:100,768,637...100,819,210
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C4b
complement C4B (Chido blood group)
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:21055120
NCBI chr20:4,302,344...4,316,752
Ensembl chr20:4,302,344...4,316,715
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Cyp1a1
cytochrome P450, family 1, subfamily a, polypeptide 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:19351467
NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
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Cyp2c6v1
cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1
susceptibility treatment
ISO
DNA:SNP: :Rs4244285(human) associated with tuberculosis; DNA.polymorphism, haplotype:cds:p.W212X (human)
RGD
PMID:23551241 , PMID:20941486
RGD:11352742 , RGD:124713543
NCBI chr 1:147,713,879...147,814,410
Ensembl chr 1:147,713,892...147,888,007
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Cyp2e1
cytochrome P450, family 2, subfamily e, polypeptide 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:19351467
NCBI chr 1:213,511,892...213,522,195
Ensembl chr 1:213,511,874...213,535,542
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Fcer1a
Fc fragment of IgE receptor Ia
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:16502481
NCBI chr13:91,727,253...91,737,106
Ensembl chr13:91,730,925...91,737,053
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Ifng
interferon gamma
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:31150805
NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419
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Il17a
interleukin 17A
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:31150805
NCBI chr 9:26,841,299...26,844,786
Ensembl chr 9:26,841,299...26,844,786
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Il18
interleukin 18
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:18204966
NCBI chr 8:55,009,666...55,016,286
Ensembl chr 8:54,993,859...55,016,299
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Il2
interleukin 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:31150805
NCBI chr 2:123,847,150...123,851,854
Ensembl chr 2:123,847,150...123,851,854
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Il4
interleukin 4
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:19351467
NCBI chr10:38,963,979...38,969,531
Ensembl chr10:38,963,979...38,969,531
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Kng2
kininogen 2
ISO
CTD Direct Evidence: marker/mechanism|therapeutic
CTD
PMID:1371395 PMID:3034372
NCBI chr11:81,509,185...81,516,759
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Mpo
myeloperoxidase
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:18204966
NCBI chr10:75,087,892...75,098,260
Ensembl chr10:75,087,892...75,098,260
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Mthfr
methylenetetrahydrofolate reductase
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:14723717
NCBI chr 5:164,844,642...164,864,360
Ensembl chr 5:164,845,925...164,860,910
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Rela
RELA proto-oncogene, NF-kB subunit
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:31150805
NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
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RT1-Ba
RT1 class II, locus Ba
susceptibility
ISO
DNA:polymorphisms:exon:
RGD
PMID:16836882
RGD:8547665
NCBI chr20:4,066,133...4,070,726
Ensembl chr20:4,066,132...4,070,721
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RT1-Bb
RT1 class II, locus Bb
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:16502481
NCBI chr20:4,043,726...4,049,367
Ensembl chr20:4,039,413...4,049,711
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Tac1
tachykinin, precursor 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:1371395
NCBI chr 4:33,638,853...33,646,819
Ensembl chr 4:33,638,709...33,646,819
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Tnf
tumor necrosis factor
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:31150805
NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000 Ensembl chr20:5,189,390...5,192,000
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Ttr
transthyretin
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:21055120
NCBI chr18:15,532,963...15,542,180
Ensembl chr18:15,532,963...15,540,177
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Hspa1l
heat shock protein family A (Hsp70) member 1 like
ISO
DNA:polymorphism, haplotype: :p.M493T (human)
RGD
PMID:15024131
RGD:8662461
NCBI chr20:4,879,998...4,965,191
Ensembl chr20:4,959,294...4,964,963
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Il1b
interleukin 1 beta
ISO
DNA:SNP:promoter:-511C>T (rs 16944) (human)
RGD
PMID:23461376
RGD:11051970
NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
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Il1rn
interleukin 1 receptor antagonist
ISO
DNA:SNP:intron:rs2234663 (human)
RGD
PMID:23461376
RGD:11051970
NCBI chr 3:1,449,778...1,468,624
Ensembl chr 3:1,452,644...1,468,614
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C3
complement C3
ISO
associated with Leprosy
RGD
PMID:2783924
RGD:7421527
NCBI chr 9:9,721,137...9,747,084
Ensembl chr 9:9,721,105...9,747,167
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Cfb
complement factor B
ISO
associated with Leprosy
RGD
PMID:2783924
RGD:7421527
NCBI chr20:4,536,206...4,542,073
Ensembl chr20:4,536,203...4,561,066 Ensembl chr20:4,536,203...4,561,066
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Gstm1
glutathione S-transferase mu 1
susceptibility
ISO
associated with Behcet Syndrome;DNA:deletion:: (human)
RGD
PMID:22766250
RGD:7794848
NCBI chr 2:210,803,869...210,809,461
Ensembl chr 2:210,803,869...210,809,306
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Lta
lymphotoxin alpha
ISO
associated with Sarcoidosis;DNA:polymorphism:intron
RGD
PMID:19225544
RGD:8548773
NCBI chr20:4,851,889...4,854,677
Ensembl chr20:4,852,496...4,854,677
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RT1-CE13
RT1 class I, locus CE13
ISO
associated with Inflammatory Bowel Diseases; DNA:polymorphisms:cds:multiple (human)
RGD
PMID:12198697
RGD:7364926
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Tnf
tumor necrosis factor
susceptibility
ISO
associated with Inflammatory Bowel Diseases;DNA:polymorphisms: :-1031T>C(human)
RGD
PMID:12198697
RGD:7364926
NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000 Ensembl chr20:5,189,390...5,192,000
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Vdr
vitamin D receptor
susceptibility
ISO
associated with Behcet Syndrome;DNA:polymorphism: : rs7975232(human)
RGD
PMID:24880677
RGD:13217417
NCBI chr 7:139,344,452...139,394,138
Ensembl chr 7:139,342,063...139,394,166
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Kdr
kinase insert domain receptor
treatment
ISO
DNA:polymorphism:cds:p.H472Q(human)
RGD
PMID:20630084
RGD:8552374
NCBI chr14:34,727,677...34,787,127
Ensembl chr14:34,727,623...34,787,183
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Alb
albumin
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:350256 PMID:9380243
NCBI chr14:19,176,275...19,191,793
Ensembl chr14:19,176,277...19,191,863
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Alb
albumin
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:12239465
NCBI chr14:19,176,275...19,191,793
Ensembl chr14:19,176,277...19,191,863
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Cav1
caveolin 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25811541
NCBI chr 4:44,597,123...44,630,206
Ensembl chr 4:44,597,123...44,630,200
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Celf2
CUGBP, Elav-like family member 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25811541
NCBI chr17:75,259,269...75,660,154
Ensembl chr17:75,352,389...75,654,951
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Clu
clusterin
ISO
mRNA:decreased expression:conjunctiva
RGD
PMID:12036968
RGD:8699507
NCBI chr15:42,626,612...42,665,858
Ensembl chr15:42,640,146...42,665,857
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Cops5
COP9 signalosome subunit 5
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25811541
NCBI chr 5:8,876,090...8,894,345
Ensembl chr 5:8,876,044...8,894,339
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Csf3
colony stimulating factor 3
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:11321886
NCBI chr10:86,616,785...86,619,160
Ensembl chr10:86,616,785...86,619,157
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Ctnnb1
catenin beta 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25811541
NCBI chr 8:129,601,511...129,628,378
Ensembl chr 8:129,617,812...129,627,372
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Cul1
cullin 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25811541
NCBI chr 4:77,211,814...77,283,369
Ensembl chr 4:77,211,692...77,280,250
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Cul4a
cullin 4A
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25811541
NCBI chr16:81,718,784...81,756,653
Ensembl chr16:81,719,028...81,756,654
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Derl1
derlin 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25811541
NCBI chr 7:97,737,176...97,759,852
Ensembl chr 7:97,737,178...97,759,852
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Elmo1
engulfment and cell motility 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25811541
NCBI chr17:46,352,102...46,888,788
Ensembl chr17:46,353,330...46,794,845
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Ep300
E1A binding protein p300
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25811541
NCBI chr 7:122,818,194...122,889,055
Ensembl chr 7:122,818,975...122,861,296
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Fbxo6
F-box protein 6
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25811541
NCBI chr 5:164,956,285...164,962,075
Ensembl chr 5:164,956,280...164,959,851
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Gstm1
glutathione S-transferase mu 1
ISO
RGD
PMID:28689274
RGD:14700974
NCBI chr 2:210,803,869...210,809,461
Ensembl chr 2:210,803,869...210,809,306
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Ifng
interferon gamma
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25811541
NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419
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Mif
macrophage migration inhibitory factor
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:9372356
NCBI chr20:13,715,219...13,732,980
Ensembl chr20:13,732,198...13,732,859
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Nedd4
NEDD4 E3 ubiquitin protein ligase
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25811541
NCBI chr 8:79,323,408...79,408,842
Ensembl chr 8:79,323,408...79,408,833
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Nfkbiz
NFKB inhibitor zeta
ISS
MouseDO
NCBI chr11:47,243,342...47,271,487
Ensembl chr11:47,243,342...47,271,487
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Nos2
nitric oxide synthase 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:10620138
NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
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Nucb1
nucleobindin 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25811541
NCBI chr 1:101,480,160...101,511,029
Ensembl chr 1:101,480,145...101,500,850
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Parp1
poly (ADP-ribose) polymerase 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25811541
NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
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Pml
PML nuclear body scaffold
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25811541
NCBI chr 8:63,002,515...63,034,310
Ensembl chr 8:63,004,870...63,034,226
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Psmc5
proteasome 26S subunit, ATPase 5
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25811541
NCBI chr10:94,445,877...94,451,811
Ensembl chr10:94,445,877...94,451,811
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Ptger3
prostaglandin E receptor 3
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:21966456
NCBI chr 2:263,895,093...263,979,682
Ensembl chr 2:263,895,241...263,979,698
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Ptgis
prostaglandin I2 synthase
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25811541
NCBI chr 3:163,950,746...163,986,129
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Rb1
RB transcriptional corepressor 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25811541
NCBI chr15:55,081,582...55,209,060
Ensembl chr15:55,083,140...55,209,342
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Rbx1
ring-box 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25811541
NCBI chr 7:122,700,849...122,710,907
Ensembl chr 7:122,700,854...122,709,935
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RT1-Bb
RT1 class II, locus Bb
susceptibility
ISO
DNA:polymorphism:cds:HLA-DQB1*0601 (human)
RGD
PMID:8841298
RGD:7483570
NCBI chr20:4,043,726...4,049,367
Ensembl chr20:4,039,413...4,049,711
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RT1-CE13
RT1 class I, locus CE13
susceptibility
ISO
DNA:polymorphisms:cds:HLA-B*5801 (human, Japanese) DNA:polymorphisms:cds:HLA-B*15:02, HLA-B*40:01, HLA-B*58:02 (human)
RGD
PMID:19018717 , PMID:23692434
RGD:7364874 , RGD:7365090
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Tnf
tumor necrosis factor
ISO
protein:increased expression:blister:
RGD
PMID:9852250
RGD:7401184
NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000 Ensembl chr20:5,189,390...5,192,000
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Vcp
valosin-containing protein
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25811541
NCBI chr 5:58,426,548...58,445,953
Ensembl chr 5:58,426,549...58,445,953
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