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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:graft-versus-host disease
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Accession:DOID:0081267 term browser browse the term
Definition:An immune system disease that is characterized by recognition by mature donor T cells, that contaminate the allogeneic bone marrow, of the recipient's tissue as foreign, causing a severe inflammatory disease characterized by rashes, diarrhea, and liver disease, and that has_material_basis_in an associated with variation in the interleukin-10 gene (IL10) on chromosome 1q32. (DO)
Synonyms:exact_synonym: GVHD;   GVHDS;   Graft vs Host Disease;   Graft-Versus-Host Diseases;   Graft-vs-Host Diseases;   Homologous Wasting Disease;   Runt Disease
 related_synonym: PECAM1 POLYMORPHISM;   PLATELET-ENDOTHELIAL CELL ADHESION MOLECULE 1 POLYMORPHISM;   graft-versus-host disease, resistance to;   graft-versus-host disease, susceptibility to
 primary_id: MESH:D006086
 alt_id: DOID:9006073;   MIM:614395
 xref: ICD11:4B24;   ORDO:39812


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graft-versus-host disease term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abo ABO, alpha 1-3-N-acetylgalactosaminyltransferase and alpha 1-3-galactosyltransferase ISO RGD PMID:3289150 RGD:11100006 NCBI chr 3:30,560,172...30,604,758 JBrowse link
G Adipoq adiponectin, C1Q and collagen domain containing severity ISO protein:increased expression:serum RGD PMID:21258011 RGD:5686893 NCBI chr11:91,226,524...91,240,244
Ensembl chr11:91,226,180...91,240,169 		JBrowse link
G Apoa4 apolipoprotein A4 ISO protein:increased expression:blood serum (human) RGD PMID:19379511 RGD:5685691 NCBI chr 8:55,435,779...55,438,160
Ensembl chr 8:55,434,168...55,438,164 		JBrowse link
G Ccr1 C-C motif chemokine receptor 1 severity ISO RGD PMID:17641205 RGD:5688177 NCBI chr 8:132,433,711...132,439,266
Ensembl chr 8:132,431,592...132,439,374 		JBrowse link
G Ccr5 C-C motif chemokine receptor 5 ISO mRNA:increased expression:lung, liver, intestine (mouse) RGD PMID:19571824 RGD:4892067 NCBI chr 8:132,629,097...132,660,980
Ensembl chr 8:132,629,683...132,637,594 		JBrowse link
G Cd40 CD40 molecule treatment ISO RGD PMID:18981161 RGD:7248735 NCBI chr 3:174,209,113...174,224,592
Ensembl chr 3:174,209,719...174,224,847 		JBrowse link
G Cd40lg CD40 ligand ISO RGD PMID:12970789 RGD:11352269 NCBI chr  X:140,164,341...140,176,057
Ensembl chr  X:140,164,302...140,176,475 		JBrowse link
G Ctla4 cytotoxic T-lymphocyte-associated protein 4 treatment ISO CTD Direct Evidence: therapeutic CTD
RGD		 PMID:14642129 PMID:7515723 RGD:11344912 NCBI chr 9:69,812,859...69,819,959
Ensembl chr 9:69,813,265...69,819,973 		JBrowse link
G Cx3cr1 C-X3-C motif chemokine receptor 1 severity ISO RGD PMID:17264819 RGD:4892014 NCBI chr 8:128,661,294...128,679,048
Ensembl chr 8:128,654,833...128,685,983 		JBrowse link
G Cxcl10 C-X-C motif chemokine ligand 10 ISO mRNA, protein:increased expression:intestine, liver, lung RGD PMID:19218194 RGD:5135435 NCBI chr14:15,989,066...15,991,263
Ensembl chr14:15,989,018...15,991,261 		JBrowse link
G Cxcl11 C-X-C motif chemokine ligand 11 ISO protein:increased expression:intestine, liver, lung RGD PMID:19218194 RGD:5135435 NCBI chr14:15,973,728...15,976,503
Ensembl chr14:15,973,720...15,976,567 		JBrowse link
G Cxcl9 C-X-C motif chemokine ligand 9 ISO mRNA, protein:increased expression:intestine, liver, lung RGD PMID:19218194 RGD:5135435 NCBI chr14:16,007,166...16,012,077
Ensembl chr14:16,007,204...16,014,299 		JBrowse link
G Cxcr3 C-X-C motif chemokine receptor 3 ISO RGD PMID:19218194 RGD:5135435 NCBI chr  X:70,884,293...70,886,944
Ensembl chr  X:70,883,958...70,886,871 		JBrowse link
G F3 coagulation factor III, tissue factor treatment ISO RGD PMID:20037809 RGD:11340209 NCBI chr 2:212,511,675...212,523,375
Ensembl chr 2:212,511,680...212,523,369 		JBrowse link
G Fas Fas cell surface death receptor ISO RGD PMID:9404931 RGD:11049160 NCBI chr 1:241,212,155...241,245,774
Ensembl chr 1:241,205,935...241,246,104 		JBrowse link
G Faslg Fas ligand ISO
IEP 		mRNA,protein:increased expression:liver: RGD PMID:9404931 PMID:10452880 RGD:11049160, RGD:14700681 NCBI chr13:76,680,885...76,706,042
Ensembl chr13:76,688,243...76,695,503 		JBrowse link
G Fcgr3a Fc gamma receptor 3A ISO DNA:polymorphism:cds:p. V158F(rs396991)(human) RGD PMID:20400988 RGD:11040884 NCBI chr13:85,782,636...85,792,656
Ensembl chr13:85,782,490...85,792,651 		JBrowse link
G Foxp3 forkhead box P3 treatment IEP RGD PMID:22344929 RGD:38599140 NCBI chr  X:17,580,380...17,601,181
Ensembl chr  X:17,580,380...17,595,894 		JBrowse link
G Gstm1 glutathione S-transferase mu 1 susceptibility ISO associated with Hemoglobinopathies; RGD PMID:20672371 RGD:10450879 NCBI chr 2:198,338,005...198,346,007
Ensembl chr 2:198,338,008...198,343,569 		JBrowse link
G Hgf hepatocyte growth factor treatment ISO RGD PMID:11390418 RGD:8548544 NCBI chr 4:19,628,902...19,700,467
Ensembl chr 4:19,632,267...19,700,851 		JBrowse link
G Hspa1a heat shock protein family A (Hsp70) member 1A severity IEP mRNA:increased expression:skin RGD PMID:18580475 RGD:8662845 NCBI chr20:3,875,411...3,877,866
Ensembl chr20:3,855,780...3,877,979 		JBrowse link
G Hspa1b heat shock protein family A (Hsp70) member 1B severity IEP mRNA:increased expression:skin RGD PMID:18580475 RGD:8662845 NCBI chr20:3,859,756...3,863,800
Ensembl chr20:3,855,780...3,877,979 		JBrowse link
G Hspa8 heat shock protein family A (Hsp70) member 8 IEP RGD PMID:9557158 RGD:7242787 NCBI chr 8:50,080,514...50,084,376
Ensembl chr 8:50,080,199...50,084,372 		JBrowse link
G Icam1 intercellular adhesion molecule 1 ISO protein:increased expression:liver,bile duct: RGD PMID:10051478 RGD:11520783 NCBI chr 8:27,829,688...27,841,618
Ensembl chr 8:27,829,161...27,841,617 		JBrowse link
G Ifng interferon gamma susceptibility ISO DNA:repeats:intron:
associated with Cytomegalovirus Infections; DNA:repeats:intron:
CTD Direct Evidence: marker/mechanism 		CTD
RGD		 PMID:22077062 PMID:16409297 PMID:19747638 RGD:10755684, RGD:10755687 NCBI chr 7:55,789,180...55,793,216
Ensembl chr 7:55,761,736...55,793,216 		JBrowse link
G Il10 interleukin 10 treatment
disease_progression
no_association
severity 		ISO DNA:SNP: :rs1800872 (human)
DNA:polymorphisms
DNA:repeat:promoter
DNA:SNPs, haplotypes:promoter:-1082G>A (rs1800896), -819C>T (rs1800871), -592C>A (rs1800872) (human)
protein:decreased expression:serum
CTD Direct Evidence: marker/mechanism
ClinVar Annotator: match by term: Graft-versus-host disease, resistance to | ClinVar Annotator: match by term: Graft-versus-host disease, susceptibility to 		CTD
ClinVar
OMIM
RGD		 PMID:11121048 PMID:14657422 PMID:14657427 PMID:18550579 PMID:25741868 More... RGD:11041897, RGD:11046269, RGD:11049171, RGD:11049177, RGD:2316565, RGD:11049180, RGD:11049455 NCBI chr13:45,024,921...45,029,586
Ensembl chr13:45,025,087...45,029,580 		JBrowse link
G Il10rb interleukin 10 receptor subunit beta disease_progression ISO DNA:SNP: :rs28341676 (human) RGD PMID:19409109 RGD:11046269 NCBI chr11:44,132,471...44,154,062
Ensembl chr11:44,132,189...44,154,053 		JBrowse link
G Il17a interleukin 17A ISO CTD Direct Evidence: marker/mechanism CTD PMID:22077062 NCBI chr 9:30,640,844...30,644,331
Ensembl chr 9:30,640,844...30,644,331 		JBrowse link
G Il19 interleukin 19 ISO ClinVar Annotator: match by term: Graft-versus-host disease, resistance to | ClinVar Annotator: match by term: Graft-versus-host disease, susceptibility to ClinVar PMID:11121048 PMID:14657422 PMID:14657427 PMID:18550579 PMID:25741868 More... NCBI chr13:44,949,989...44,958,714
Ensembl chr13:44,949,989...44,958,714 		JBrowse link
G Il1a interleukin 1 alpha ISO DNA:SNP:promoter:-889T>C (rs1800587) (human) RGD PMID:23645090 RGD:11049180 NCBI chr 3:136,979,804...136,990,236
Ensembl chr 3:136,979,805...136,998,013 		JBrowse link
G Il1rn interleukin 1 receptor antagonist ISO RGD PMID:8049450 RGD:6909143 NCBI chr 3:27,509,836...27,525,738
Ensembl chr 3:27,509,798...27,525,732 		JBrowse link
G Il2 interleukin 2 ISO RGD PMID:21734238 PMID:8704686 RGD:5147911, RGD:8662974 NCBI chr 2:121,932,968...121,937,672
Ensembl chr 2:121,932,968...121,937,672 		JBrowse link
G Il21r interleukin 21 receptor ISO RGD PMID:21596854 RGD:6892927 NCBI chr 1:189,598,682...189,626,340
Ensembl chr 1:189,598,558...189,626,342 		JBrowse link
G Itga2 integrin subunit alpha 2 treatment ISO RGD PMID:11489992 RGD:8693305 NCBI chr 2:48,253,412...48,354,509
Ensembl chr 2:48,253,412...48,354,509 		JBrowse link
G Jak3 Janus kinase 3 treatment ISO
IMP 		RGD PMID:12010825 PMID:11781254 RGD:11531124, RGD:1600262 NCBI chr16:18,418,807...18,432,515
Ensembl chr16:18,420,415...18,433,222 		JBrowse link
G Lst1 leukocyte specific transcript 1 ISO DNA:repeat:intron:IVS3dupGA (human) RGD PMID:9808588 RGD:2316565 NCBI chr20:3,639,353...3,644,399
Ensembl chr20:3,639,341...3,642,669 		JBrowse link
G Mir146a microRNA 146a ameliorates ISO RGD PMID:28853768 RGD:126925178 NCBI chr10:28,349,996...28,350,090 JBrowse link
G Mki67 marker of proliferation Ki-67 ISO RGD PMID:21440078 RGD:6483534 NCBI chr 1:199,926,150...199,952,847
Ensembl chr 1:199,926,150...199,952,593 		JBrowse link
G Mthfr methylenetetrahydrofolate reductase treatment ISO DNA:transition:cds:g.677C>T (human)
CTD Direct Evidence: marker/mechanism 		CTD
RGD		 PMID:16518429 PMID:19005482 RGD:6893635 NCBI chr 5:163,748,346...163,768,141
Ensembl chr 5:163,748,321...163,768,105 		JBrowse link
G Nod2 nucleotide-binding oligomerization domain containing 2 severity ISO DNA:snps, insertion:exons:p.R675W, p.G1881R, c.2936_2937insC (human) RGD PMID:15090455 RGD:8158050 NCBI chr19:34,555,832...34,596,281
Ensembl chr19:34,555,832...34,722,846 		JBrowse link
G Pdgfb platelet derived growth factor subunit B ISO RGD PMID:21211989 RGD:6482796 NCBI chr 7:113,419,882...113,438,343
Ensembl chr 7:113,420,710...113,438,343 		JBrowse link
G Pecam1 platelet and endothelial cell adhesion molecule 1 ISO ClinVar Annotator: match by term: PECAM1 POLYMORPHISM ClinVar PMID:8532023 NCBI chr10:92,090,263...92,152,002
Ensembl chr10:92,090,235...92,151,839 		JBrowse link
G Pik3cg phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma ISO RGD PMID:21402770 RGD:6482681 NCBI chr 6:54,494,247...54,529,563
Ensembl chr 6:54,478,603...54,529,509 		JBrowse link
G Ptpn22 protein tyrosine phosphatase, non-receptor type 22 susceptibility ISO DNA:snp:promoter:g.-1123G>C (rs2488457) (human) RGD PMID:23025987 RGD:11534005 NCBI chr 2:194,055,165...194,103,209
Ensembl chr 2:194,045,746...194,103,209 		JBrowse link
G RT1-A1 RT1 class Ia, locus A1 IDA RGD PMID:11045643 RGD:2313505 NCBI chr20:4,907,139...4,910,798 JBrowse link
G RT1-Hb-ps1 RT1 class II, locus Hb, pseudogene 1 severity ISO DNA:polymorphsims: :multiple (human) RGD PMID:12774051 RGD:150429809 NCBI chr20:4,777,494...4,781,486
Ensembl chr20:4,776,547...4,781,574 		JBrowse link
G Sell selectin L ISO RGD PMID:21635226 RGD:5685693 NCBI chr13:78,950,100...78,969,604
Ensembl chr13:78,950,015...78,969,600 		JBrowse link
G Serpine1 serpin family E member 1 Treatment ISO RGD PMID:26414805 RGD:11343779 NCBI chr12:25,237,977...25,248,356
Ensembl chr12:25,237,952...25,248,357 		JBrowse link
G Tfpi tissue factor pathway inhibitor treatment ISO RGD PMID:20037809 RGD:11340209 NCBI chr 3:89,939,862...89,989,253
Ensembl chr 3:89,939,868...89,980,742 		JBrowse link
G Tnfrsf8 TNF receptor superfamily member 8 ISO CTD Direct Evidence: marker/mechanism CTD PMID:15322151 NCBI chr 5:162,406,387...162,451,620
Ensembl chr 5:162,406,387...162,451,620 		JBrowse link
G Tnfsf8 TNF superfamily member 8 ISO CTD Direct Evidence: marker/mechanism CTD PMID:15322151 NCBI chr 5:82,266,436...82,292,858
Ensembl chr 5:82,266,436...82,292,858 		JBrowse link
G Tp53 tumor protein p53 ISO protein:increased expression:epithelium RGD PMID:16393253 RGD:8547841 NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,798,851...54,810,299 		JBrowse link
G Ugt2b1 UDP glucuronosyltransferase 2 family, polypeptide B1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19935662 NCBI chr14:21,378,882...21,390,631
Ensembl chr14:21,378,853...21,392,331 		JBrowse link
G Vegfa vascular endothelial growth factor A ISO protein:decreased expression:serum: RGD PMID:25759146 RGD:11079181 NCBI chr 9:22,452,854...22,468,194
Ensembl chr 9:22,439,392...22,468,194 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 19167
    disease of anatomical entity 18473
      immune system disease 5094
        graft-versus-host disease 54
          Bronchiolitis Obliterans Syndrome 0
Path 2
Term Annotations click to browse term
  disease 19167
    disease of anatomical entity 18473
      Immune & Inflammatory Diseases 5781
        immune system disease 5094
          graft-versus-host disease 54
            Bronchiolitis Obliterans Syndrome 0
paths to the root