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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:graft-versus-host disease
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Accession:DOID:0081267 term browser browse the term
Definition:An immune system disease that is characterized by recognition by mature donor T cells, that contaminate the allogeneic bone marrow, of the recipient's tissue as foreign, causing a severe inflammatory disease characterized by rashes, diarrhea, and liver disease, and that has_material_basis_in an associated with variation in the interleukin-10 gene (IL10) on chromosome 1q32. (DO)
Synonyms:exact_synonym: GVHD;   GVHDS;   Graft vs Host Disease;   Graft-Versus-Host Diseases;   Graft-vs-Host Diseases;   Homologous Wasting Disease;   Runt Disease
 related_synonym: PLATELET-ENDOTHELIAL CELL ADHESION MOLECULE 1 POLYMORPHISM;   graft-versus-host disease, resistance to;   graft-versus-host disease, susceptibility to
 primary_id: MESH:D006086
 alt_id: DOID:9006073;   MIM:614395
 xref: ICD11:4B24;   ORDO:39812


show annotations for term's descendants           Sort by:
graft-versus-host disease term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abo ABO, alpha 1-3-N-acetylgalactosaminyltransferase and alpha 1-3-galactosyltransferase ISO RGD PMID:3289150 RGD:11100006 NCBI chr 3:10,162,087...10,182,835
Ensembl chr 3:10,162,096...10,191,423 		JBrowse link
G Adipoq adiponectin, C1Q and collagen domain containing severity ISO protein:increased expression:serum RGD PMID:21258011 RGD:5686893 NCBI chr11:77,721,912...77,735,644
Ensembl chr11:77,721,912...77,735,564 		JBrowse link
G Apoa4 apolipoprotein A4 ISO protein:increased expression:blood serum (human) RGD PMID:19379511 RGD:5685691 NCBI chr 8:46,539,083...46,541,464
Ensembl chr 8:46,539,082...46,541,469 		JBrowse link
G Ccr1 C-C motif chemokine receptor 1 severity ISO RGD PMID:17641205 RGD:5688177 NCBI chr 8:123,556,286...123,561,841 JBrowse link
G Ccr5 C-C motif chemokine receptor 5 ISO mRNA:increased expression:lung, liver, intestine (mouse) RGD PMID:19571824 RGD:4892067 NCBI chr 8:123,752,423...123,757,538
Ensembl chr 8:123,752,325...123,759,260 		JBrowse link
G Cd40 CD40 molecule treatment ISO RGD PMID:18981161 RGD:7248735 NCBI chr 3:153,790,372...153,805,279
Ensembl chr 3:153,790,449...153,805,534 		JBrowse link
G Cd40lg CD40 ligand ISO RGD PMID:12970789 RGD:11352269 NCBI chr  X:135,127,052...135,138,768
Ensembl chr  X:135,126,969...135,138,306 		JBrowse link
G Ctla4 cytotoxic T-lymphocyte-associated protein 4 treatment ISO CTD Direct Evidence: therapeutic CTD
RGD		 PMID:14642129 PMID:7515723 RGD:11344912 NCBI chr 9:62,318,874...62,325,978
Ensembl chr 9:62,319,312...62,324,963 		JBrowse link
G Cx3cr1 C-X3-C motif chemokine receptor 1 severity ISO RGD PMID:17264819 RGD:4892014 NCBI chr 8:119,785,726...119,799,431
Ensembl chr 8:119,782,595...119,800,014 		JBrowse link
G Cxcl10 C-X-C motif chemokine ligand 10 ISO mRNA, protein:increased expression:intestine, liver, lung RGD PMID:19218194 RGD:5135435 NCBI chr14:15,704,772...15,706,969
Ensembl chr14:15,704,758...15,706,975 		JBrowse link
G Cxcl11 C-X-C motif chemokine ligand 11 ISO protein:increased expression:intestine, liver, lung RGD PMID:19218194 RGD:5135435 NCBI chr14:15,689,432...15,692,207
Ensembl chr14:15,689,424...15,692,271 		JBrowse link
G Cxcl9 C-X-C motif chemokine ligand 9 ISO mRNA, protein:increased expression:intestine, liver, lung RGD PMID:19218194 RGD:5135435 NCBI chr14:15,722,868...15,727,779
Ensembl chr14:15,722,908...15,728,435 		JBrowse link
G Cxcr3 C-X-C motif chemokine receptor 3 ISO RGD PMID:19218194 RGD:5135435 NCBI chr  X:66,844,318...66,846,969
Ensembl chr  X:66,844,318...66,846,969 		JBrowse link
G F3 coagulation factor III, tissue factor treatment ISO RGD PMID:20037809 RGD:11340209 NCBI chr 2:209,827,061...209,838,666
Ensembl chr 2:209,826,959...209,838,668 		JBrowse link
G Fas Fas cell surface death receptor ISO RGD PMID:9404931 RGD:11049160 NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591 		JBrowse link
G Faslg Fas ligand ISO
IEP		 mRNA,protein:increased expression:liver: RGD PMID:9404931 PMID:10452880 RGD:11049160, RGD:14700681 NCBI chr13:74,151,519...74,172,760
Ensembl chr13:74,154,954...74,162,215 		JBrowse link
G Fcgr3a Fc gamma receptor 3A ISO DNA:polymorphism:cds:p. V158F(rs396991)(human) RGD PMID:20400988 RGD:11040884 NCBI chr13:83,249,905...83,259,921
Ensembl chr13:83,249,872...83,259,921 		JBrowse link
G Foxp3 forkhead box P3 treatment IEP RGD PMID:22344929 RGD:38599140 NCBI chr  X:14,908,494...14,924,994
Ensembl chr  X:14,908,494...14,923,838 		JBrowse link
G Gstm1 glutathione S-transferase mu 1 susceptibility ISO associated with Hemoglobinopathies; RGD PMID:20672371 RGD:10450879 NCBI chr 2:195,649,845...195,655,402
Ensembl chr 2:195,649,845...195,655,411 		JBrowse link
G Hgf hepatocyte growth factor treatment ISO RGD PMID:11390418 RGD:8548544 NCBI chr 4:18,673,736...18,745,582
Ensembl chr 4:18,677,101...18,745,409 		JBrowse link
G Hspa1a heat shock protein family A (Hsp70) member 1A severity IEP mRNA:increased expression:skin RGD PMID:18580475 RGD:8662845 NCBI chr20:3,870,765...3,873,221
Ensembl chr20:3,856,006...3,873,227 		JBrowse link
G Hspa1b heat shock protein family A (Hsp70) member 1B severity IEP mRNA:increased expression:skin RGD PMID:18580475 RGD:8662845 NCBI chr20:3,855,104...3,859,148
Ensembl chr20:3,856,006...3,873,240
Ensembl chr20:3,856,006...3,873,240 		JBrowse link
G Hspa8 heat shock protein family A (Hsp70) member 8 IEP RGD PMID:9557158 RGD:7242787 NCBI chr 8:41,183,397...41,187,260
Ensembl chr 8:41,183,264...41,187,259 		JBrowse link
G Icam1 intercellular adhesion molecule 1 ISO protein:increased expression:liver,bile duct: RGD PMID:10051478 RGD:11520783 NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438 		JBrowse link
G Ifng interferon gamma susceptibility ISO DNA:repeats:intron:
associated with Cytomegalovirus Infections; DNA:repeats:intron:
CTD Direct Evidence: marker/mechanism		 CTD
RGD		 PMID:22077062 PMID:16409297 PMID:19747638 RGD:10755684, RGD:10755687 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375 		JBrowse link
G Il10 interleukin 10 treatment
disease_progression
no_association
severity		 ISO DNA:SNP: :rs1800872 (human)
DNA:polymorphisms
DNA:repeat:promoter
DNA:SNPs, haplotypes:promoter:-1082G>A (rs1800896), -819C>T (rs1800871), -592C>A (rs1800872) (human)
protein:decreased expression:serum
CTD Direct Evidence: marker/mechanism
ClinVar Annotator: match by term: Graft-versus-host disease, resistance to | ClinVar Annotator: match by term: Graft-versus-host disease, susceptibility to		 CTD
ClinVar
OMIM
RGD		 PMID:11121048 PMID:14657422 PMID:14657427 PMID:18550579 PMID:25741868 More... RGD:11041897, RGD:11046269, RGD:11049171, RGD:11049177, RGD:2316565, RGD:11049180, RGD:11049455 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313 		JBrowse link
G Il10rb interleukin 10 receptor subunit beta disease_progression ISO DNA:SNP: :rs28341676 (human) RGD PMID:19409109 RGD:11046269 NCBI chr11:30,646,494...30,668,081
Ensembl chr11:30,652,096...30,668,074 		JBrowse link
G Il17a interleukin 17A ISO CTD Direct Evidence: marker/mechanism CTD PMID:22077062 NCBI chr 9:23,144,402...23,147,889
Ensembl chr 9:23,144,402...23,147,889 		JBrowse link
G Il19 interleukin 19 ISO ClinVar Annotator: match by term: Graft-versus-host disease, resistance to | ClinVar Annotator: match by term: Graft-versus-host disease, susceptibility to ClinVar PMID:11121048 PMID:14657422 PMID:14657427 PMID:18550579 PMID:25741868 More... NCBI chr13:42,397,715...42,411,637
Ensembl chr13:42,399,138...42,405,473 		JBrowse link
G Il1a interleukin 1 alpha ISO DNA:SNP:promoter:-889T>C (rs1800587) (human) RGD PMID:23645090 RGD:11049180 NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822 		JBrowse link
G Il1rn interleukin 1 receptor antagonist ISO RGD PMID:8049450 RGD:6909143 NCBI chr 3:7,111,567...7,127,451
Ensembl chr 3:7,111,550...7,127,445 		JBrowse link
G Il2 interleukin 2 ISO RGD PMID:21734238 PMID:8704686 RGD:5147911, RGD:8662974 NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566 		JBrowse link
G Il21r interleukin 21 receptor ISO RGD PMID:21596854 RGD:6892927 NCBI chr 1:180,168,028...180,195,690
Ensembl chr 1:180,168,097...180,195,522 		JBrowse link
G Itga2 integrin subunit alpha 2 treatment ISO RGD PMID:11489992 RGD:8693305 NCBI chr 2:46,520,345...46,621,487
Ensembl chr 2:46,523,948...46,621,481 		JBrowse link
G Jak3 Janus kinase 3 treatment ISO
IMP		 RGD PMID:12010825 PMID:11781254 RGD:11531124, RGD:1600262 NCBI chr16:18,386,330...18,398,542
Ensembl chr16:18,386,405...18,398,536 		JBrowse link
G Lst1 leukocyte specific transcript 1 ISO DNA:repeat:intron:IVS3dupGA (human) RGD PMID:9808588 RGD:2316565 NCBI chr20:3,634,680...3,639,731
Ensembl chr20:3,634,749...3,637,997 		JBrowse link
G Mir146a microRNA 146a ameliorates ISO RGD PMID:28853768 RGD:126925178 NCBI chr10:27,848,516...27,848,610
Ensembl chr10:27,848,516...27,848,610 		JBrowse link
G Mki67 marker of proliferation Ki-67 ISO RGD PMID:21440078 RGD:6483534 NCBI chr 1:190,496,319...190,522,983
Ensembl chr 1:190,496,319...190,522,762 		JBrowse link
G Mthfr methylenetetrahydrofolate reductase treatment ISO DNA:transition:cds:g.677C>T (human)
CTD Direct Evidence: marker/mechanism		 CTD
RGD		 PMID:16518429 PMID:19005482 RGD:6893635 NCBI chr 5:158,465,248...158,484,999
Ensembl chr 5:158,465,296...158,483,797 		JBrowse link
G Nod2 nucleotide-binding oligomerization domain containing 2 severity ISO DNA:snps, insertion:exons:p.R675W, p.G1881R, c.2936_2937insC (human) RGD PMID:15090455 RGD:8158050 NCBI chr19:18,382,369...18,422,817
Ensembl chr19:18,382,439...18,417,177 		JBrowse link
G Pdgfb platelet derived growth factor subunit B ISO RGD PMID:21211989 RGD:6482796 NCBI chr 7:111,539,444...111,557,984
Ensembl chr 7:111,540,345...111,557,984 		JBrowse link
G Pecam1 platelet and endothelial cell adhesion molecule 1 ISO ClinVar Annotator: match by term: PLATELET-ENDOTHELIAL CELL ADHESION MOLECULE 1 POLYMORPHISM ClinVar PMID:8532023 NCBI chr10:91,590,521...91,652,279
Ensembl chr10:91,590,521...91,652,116 		JBrowse link
G Pik3cg phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma ISO RGD PMID:21402770 RGD:6482681 NCBI chr 6:48,766,778...48,802,098
Ensembl chr 6:48,766,864...48,802,043 		JBrowse link
G Ptpn22 protein tyrosine phosphatase, non-receptor type 22 susceptibility ISO DNA:snp:promoter:g.-1123G>C (rs2488457) (human) RGD PMID:23025987 RGD:11534005 NCBI chr 2:191,366,761...191,414,782
Ensembl chr 2:191,366,808...191,414,779 		JBrowse link
G RT1-A1 RT1 class Ia, locus A1 IDA RGD PMID:11045643 RGD:2313505 NCBI chr20:4,905,309...4,914,593 JBrowse link
G RT1-Hb-ps1 RT1 class II, locus Hb, pseudogene 1 severity ISO DNA:polymorphsims: :multiple (human) RGD PMID:12774051 RGD:150429809 NCBI chr20:4,775,598...4,779,590
Ensembl chr20:4,774,650...4,780,618 		JBrowse link
G Sell selectin L ISO RGD PMID:21635226 RGD:5685693 NCBI chr13:76,416,969...76,436,444
Ensembl chr13:76,416,915...76,436,456 		JBrowse link
G Serpine1 serpin family E member 1 Treatment ISO RGD PMID:26414805 RGD:11343779 NCBI chr12:19,601,272...19,611,657
Ensembl chr12:19,601,272...19,611,657 		JBrowse link
G Tfpi tissue factor pathway inhibitor treatment ISO RGD PMID:20037809 RGD:11340209 NCBI chr 3:69,533,156...69,582,547
Ensembl chr 3:69,533,156...69,576,880 		JBrowse link
G Tnfrsf8 TNF receptor superfamily member 8 ISO CTD Direct Evidence: marker/mechanism CTD PMID:15322151 NCBI chr 5:157,123,183...157,168,421
Ensembl chr 5:157,123,185...157,168,421 		JBrowse link
G Tnfsf8 TNF superfamily member 8 ISO CTD Direct Evidence: marker/mechanism CTD PMID:15322151 NCBI chr 5:77,250,942...77,277,364
Ensembl chr 5:77,251,373...77,277,421 		JBrowse link
G Tp53 tumor protein p53 ISO protein:increased expression:epithelium RGD PMID:16393253 RGD:8547841 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
G Ugt2b1 UDP glucuronosyltransferase 2 family, polypeptide B1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19935662 NCBI chr14:21,024,035...21,035,784
Ensembl chr14:21,024,006...21,035,986 		JBrowse link
G Vegfa vascular endothelial growth factor A ISO protein:decreased expression:serum: RGD PMID:25759146 RGD:11079181 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 19047
    disease of anatomical entity 18381
      immune system disease 4931
        graft-versus-host disease 54
          Bronchiolitis Obliterans Syndrome 0
Path 2
Term Annotations click to browse term
  disease 19047
    disease of anatomical entity 18381
      Immune & Inflammatory Diseases 5742
        immune system disease 4931
          graft-versus-host disease 54
            Bronchiolitis Obliterans Syndrome 0
paths to the root