RGD DISEASE ONTOLOGY - ANNOTATIONS
RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term: Ventricular Remodeling
Accession: DOID:9007174
browse the term
Definition: The geometric and structural changes that the HEART VENTRICLES undergo, usually following MYOCARDIAL INFARCTION. It comprises expansion of the infarct and dilatation of the healthy ventricle segments. While most prevalent in the left ventricle, it can also occur in the right ventricle.
Synonyms: exact_synonym: Left Ventricle Remodeling; Left Ventricle Remodelings; Left Ventricular Remodeling; Left Ventricular Remodelings; Ventricle Remodeling; Ventricle Remodelings; Ventricular Cardiac Remodeling; Ventricular Cardiac Remodelings; Ventricular Myocardial Remodeling; Ventricular Myocardial Remodelings; Ventricular Remodelings
primary_id: MESH:D020257 ; RDO:0007377
For additional species annotation, visit the
Alliance of Genome Resources .
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Ace
angiotensin I converting enzyme
treatment
IDA
associated with Acute Kidney Injury
RGD
PMID:18223026
RGD:9685440
NCBI chr10:90,910,316...90,930,437
Ensembl chr10:90,910,316...90,931,131
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Ace2
angiotensin I converting enzyme 2
treatment
ISO IEP
associated with Diabetic Cardiomyopathies associated with Myocardial Infarction associated with Acute Kidney Injury
RGD
PMID:22340266 PMID:20507236 PMID:18223026
RGD:9685428 , RGD:9685439 , RGD:9685440
NCBI chr X:30,293,597...30,340,961
Ensembl chr X:30,293,589...30,340,977
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Adra1a
adrenoceptor alpha 1A
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:20668454
NCBI chr15:40,830,125...40,935,902
Ensembl chr15:40,832,534...40,927,500
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Agt
angiotensinogen
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:29353218
NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977
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Agtr1a
angiotensin II receptor, type 1a
IEP
RGD
PMID:18252761
RGD:10047108
NCBI chr17:34,173,446...34,226,892
Ensembl chr17:34,174,429...34,226,946
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Axin2
axin 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:29394407
NCBI chr10:93,893,830...93,927,042
Ensembl chr10:93,899,245...93,926,231
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Ctnnb1
catenin beta 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:29394407
NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111
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Dstn
destrin, actin depolymerizing factor
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:29394407
NCBI chr 3:131,284,647...131,311,361
Ensembl chr 3:131,284,648...131,311,379
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Fis1
fission, mitochondrial 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:20886221
NCBI chr12:19,708,558...19,723,392
Ensembl chr12:19,708,558...19,723,377
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Gata4
GATA binding protein 4
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:29394407
NCBI chr15:37,459,601...37,531,291
Ensembl chr15:37,459,601...37,505,636
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Hand2
heart and neural crest derivatives expressed 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:29394407
NCBI chr16:32,917,826...32,919,880
Ensembl chr16:32,917,823...32,919,891
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Map3k5
mitogen-activated protein kinase kinase kinase 5
ISO
protein:increased activity:heart:
RGD
PMID:14665690
RGD:10412322
NCBI chr 1:14,685,776...14,904,935
Ensembl chr 1:14,685,492...14,904,800
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Mfn2
mitofusin 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:20886221
NCBI chr 5:158,304,285...158,335,502
Ensembl chr 5:158,304,287...158,335,342
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Nfe2l2
NFE2 like bZIP transcription factor 2
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:29353218
NCBI chr 3:60,594,239...60,621,785
Ensembl chr 3:60,594,242...60,621,737
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Nos1
nitric oxide synthase 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:16344403
NCBI chr12:38,615,111...38,795,492
Ensembl chr12:38,626,714...38,710,945
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Nppa
natriuretic peptide A
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:20886221
NCBI chr 5:158,429,042...158,430,351
Ensembl chr 5:158,429,042...158,430,351
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Nppb
natriuretic peptide B
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:29394407
NCBI chr 5:158,416,813...158,418,175
Ensembl chr 5:158,416,866...158,418,168
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Opa1
OPA1, mitochondrial dynamin like GTPase
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:20886221
NCBI chr11:71,108,100...71,185,170
Ensembl chr11:71,109,873...71,185,109
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Rock2
Rho-associated coiled-coil containing protein kinase 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:29394407
NCBI chr 6:39,679,116...39,774,033
Ensembl chr 6:39,679,082...39,774,031
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Sirt6
sirtuin 6
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:34713381
NCBI chr 7:8,082,312...8,087,776
Ensembl chr 7:8,082,364...8,098,914
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Slc9a1
solute carrier family 9 member A1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:20886221
NCBI chr 5:145,576,341...145,629,630
Ensembl chr 5:145,576,334...145,629,624
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Smad2
SMAD family member 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:16635409
NCBI chr18:69,849,884...69,918,926
Ensembl chr18:69,850,377...69,912,323
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Smad3
SMAD family member 3
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:16635409
NCBI chr 8:64,126,829...64,236,960
Ensembl chr 8:64,110,039...64,236,960
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Tbx20
T-box transcription factor 20
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:29394407
NCBI chr 8:23,200,104...23,258,218
Ensembl chr 8:23,204,507...23,258,175
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Tcf7l2
transcription factor 7 like 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:29394407
NCBI chr 1:254,785,956...254,978,967
Ensembl chr 1:254,786,091...254,978,967
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Tgfb1
transforming growth factor, beta 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:16635409
NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
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