RGD DISEASE ONTOLOGY - ANNOTATIONS
RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term: Ventricular Remodeling
Accession: DOID:9007174
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Definition: The geometric and structural changes that the HEART VENTRICLES undergo, usually following MYOCARDIAL INFARCTION. It comprises expansion of the infarct and dilatation of the healthy ventricle segments. While most prevalent in the left ventricle, it can also occur in the right ventricle.
Synonyms: exact_synonym: Left Ventricle Remodeling; Left Ventricle Remodelings; Left Ventricular Remodeling; Left Ventricular Remodelings; Ventricle Remodeling; Ventricle Remodelings; Ventricular Cardiac Remodeling; Ventricular Cardiac Remodelings; Ventricular Myocardial Remodeling; Ventricular Myocardial Remodelings; Ventricular Remodelings
primary_id: MESH:D020257
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Ace
angiotensin I converting enzyme
treatment
IDA
associated with Acute Kidney Injury
RGD
PMID:18223026
RGD:9685440
NCBI chr10:91,410,129...91,430,246
Ensembl chr10:91,409,819...91,430,942
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Ace2
angiotensin converting enzyme 2
treatment
ISO IEP
associated with Diabetic Cardiomyopathies associated with Myocardial Infarction associated with Acute Kidney Injury
RGD
PMID:22340266 PMID:20507236 PMID:18223026
RGD:9685428 , RGD:9685439 , RGD:9685440
NCBI chr X:33,925,458...33,972,851
Ensembl chr X:33,925,458...33,971,596
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Adra1a
adrenoceptor alpha 1A
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:20668454
NCBI chr15:45,005,648...45,111,416
Ensembl chr15:45,005,799...45,102,534
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Agt
angiotensinogen
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:29353218
NCBI chr19:69,426,540...69,447,017
Ensembl chr19:69,421,638...69,446,944
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Agtr1a
angiotensin II receptor, type 1a
IEP
RGD
PMID:18252761
RGD:10047108
NCBI chr17:34,383,397...34,435,523
Ensembl chr17:34,381,467...34,435,660
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Ahr
aryl hydrocarbon receptor
IEP
associated with diesel exhaust particulates exposure; protein:increased expression:heart left ventricle (rat)
RGD
PMID:23887904
RGD:401794424
NCBI chr 6:57,961,423...57,998,901
Ensembl chr 6:57,961,423...57,998,901
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Akt1
AKT serine/threonine kinase 1
treatment
IEP ISO
CTD Direct Evidence: therapeutic
CTD RGD
PMID:39477182 PMID:18656339
RGD:407419882
NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:137,535,390...137,552,610
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Axin2
axin 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:29394407
NCBI chr10:94,393,379...94,426,579
Ensembl chr10:94,395,909...94,426,575
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Bax
BCL2 associated X, apoptosis regulator
ameliorates
ISO
associated with myocardial infarction
RGD
PMID:25726944
RGD:11252030
NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:105,076,473...105,086,429
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Bcl2
BCL2, apoptosis regulator
ameliorates
ISO
associated with myocardial infarction
RGD
PMID:25726944
RGD:11252030
NCBI chr13:23,204,464...23,366,900
Ensembl chr13:23,204,464...23,366,900
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Casp3
caspase 3
ameliorates
ISO
associated with myocardial infarction
RGD
PMID:25726944
RGD:11252030
NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732
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Ctnnb1
catenin beta 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:29394407
NCBI chr 8:129,517,576...129,544,661
Ensembl chr 8:129,517,545...129,544,662
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Cyp1a1
cytochrome P450, family 1, subfamily a, polypeptide 1
IEP
associated with diesel exhaust particulates exposure; protein:increased expression:heart left ventricle (rat)
RGD
PMID:23887904
RGD:401794424
NCBI chr 8:66,991,940...66,998,014
Ensembl chr 8:66,991,970...66,998,012
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Dstn
destrin, actin depolymerizing factor
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:29394407
NCBI chr 3:151,737,711...151,764,752
Ensembl chr 3:151,737,849...151,764,769
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Fis1
fission, mitochondrial 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:20886221
NCBI chr12:25,345,239...25,360,135
Ensembl chr12:25,345,239...25,349,335
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Gata4
GATA binding protein 4
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:29394407
NCBI chr15:41,635,572...41,707,252
Ensembl chr15:41,635,572...41,681,609
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Gdf1
growth differentiation factor 1
ameliorates
ISO
associated with myocardial infarction
RGD
PMID:25726944
RGD:11252030
NCBI chr16:19,131,271...19,146,480
Ensembl chr16:19,131,276...19,146,480
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Gsn
gelsolin
ameliorates
ISO
RGD
PMID:19246681
RGD:329333014
NCBI chr 3:38,982,605...39,035,849
Ensembl chr 3:38,982,671...39,035,850
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Hand2
heart and neural crest derivatives expressed 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:29394407
NCBI chr16:37,928,145...37,931,488
Ensembl chr16:37,928,145...37,931,488
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Hif1a
hypoxia inducible factor 1 subunit alpha
IEP
associated with diesel exhaust particulates exposure; protein:decreased expression:heart left ventricle (rat)
RGD
PMID:23887904
RGD:401794424
NCBI chr 6:98,357,788...98,405,068
Ensembl chr 6:98,359,910...98,405,323
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Kcnn4
potassium calcium-activated channel subfamily N member 4
ameliorates
ISO
associated with myocardial infarction
RGD
PMID:26160442
RGD:329969895
NCBI chr 1:89,084,306...89,102,279
Ensembl chr 1:89,086,814...89,102,275
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Lep
leptin
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:38906502
NCBI chr 4:58,626,529...58,640,663
Ensembl chr 4:58,626,523...58,640,661
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Ltbp2
latent transforming growth factor beta binding protein 2
ISO
mRNA:increased expression:heart (mouse)
RGD
PMID:31364721
RGD:213230159
NCBI chr 6:104,429,947...104,530,498
Ensembl chr 6:110,161,029...110,257,298
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Map3k5
mitogen-activated protein kinase kinase kinase 5
ISO
protein:increased activity:heart:
RGD
PMID:14665690
RGD:10412322
NCBI chr 1:16,505,387...16,723,899
Ensembl chr 1:16,505,596...16,723,898
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Mfn2
mitofusin 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:20886221
NCBI chr 5:163,587,463...163,617,363
Ensembl chr 5:163,587,463...163,618,495
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Mir140
microRNA 140
ameliorates
IEP
RGD
PMID:28922712
RGD:329347824
NCBI chr19:52,375,293...52,375,391
Ensembl chr19:52,375,293...52,375,391
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Nfe2l2
NFE2 like bZIP transcription factor 2
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:29353218
NCBI chr 3:81,001,529...81,031,165
Ensembl chr 3:81,001,529...81,029,090
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Nos1
nitric oxide synthase 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:16344403
NCBI chr12:44,276,011...44,456,371
Ensembl chr12:44,287,614...44,371,837
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Nppa
natriuretic peptide A
ameliorates
ISO
CTD Direct Evidence: marker/mechanism associated with myocardial infarction
CTD RGD
PMID:20886221 PMID:25726944
RGD:11252030
NCBI chr 5:163,712,184...163,713,493
Ensembl chr 5:163,712,184...163,713,493
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Nppb
natriuretic peptide B
ameliorates
ISO
CTD Direct Evidence: marker/mechanism associated with myocardial infarction
CTD RGD
PMID:29394407 PMID:25726944
RGD:11252030
NCBI chr 5:163,699,955...163,701,314
Ensembl chr 5:163,699,839...163,701,310
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Opa1
OPA1, mitochondrial dynamin like GTPase
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:20886221
NCBI chr11:84,612,943...84,690,025
Ensembl chr11:84,615,340...84,689,955
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Rock2
Rho-associated coiled-coil containing protein kinase 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:29394407
NCBI chr 6:45,407,823...45,502,773
Ensembl chr 6:45,407,965...45,502,771
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Sirt6
sirtuin 6
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:34713381
NCBI chr 7:8,733,056...8,738,543
Ensembl chr 7:8,732,974...8,738,542
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Slc9a1
solute carrier family 9 member A1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:20886221
NCBI chr 5:150,859,412...150,913,525
Ensembl chr 5:150,860,228...150,913,517
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Smad2
SMAD family member 2
ameliorates
ISO
CTD Direct Evidence: marker/mechanism associated with myocardial infarction
CTD RGD
PMID:16635409 PMID:25726944
RGD:11252030
NCBI chr18:72,124,792...72,193,345
Ensembl chr18:72,124,863...72,187,388
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Smad3
SMAD family member 3
ameliorates
ISO
CTD Direct Evidence: marker/mechanism associated with myocardial infarction
CTD RGD
PMID:16635409 PMID:25726944
RGD:11252030
NCBI chr 8:73,022,204...73,132,324
Ensembl chr 8:73,024,760...73,132,324
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Tbx20
T-box transcription factor 20
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:29394407
NCBI chr 8:31,475,963...31,534,051
Ensembl chr 8:31,475,963...31,534,009
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Tcf7l2
transcription factor 7 like 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:29394407
NCBI chr 1:264,791,335...264,984,225
Ensembl chr 1:264,791,335...264,984,225
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Tgfb1
transforming growth factor, beta 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:16635409
NCBI chr 1:90,324,312...90,340,627
Ensembl chr 1:90,324,046...90,340,899
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Tnnt2
troponin T2, cardiac type
IEP
associated with diesel exhaust particulates exposure; protein:increased expression:heart left ventricle (rat)
RGD
PMID:23887904
RGD:401794424
NCBI chr13:49,819,123...49,837,125
Ensembl chr13:49,822,304...49,837,125
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Vegfa
vascular endothelial growth factor A
IEP
associated with diesel exhaust particulates exposure; protein:decreased expression:heart left ventricle (rat)
RGD
PMID:23887904
RGD:401794424
NCBI chr 9:22,452,854...22,468,194
Ensembl chr 9:22,439,392...22,468,194
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