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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:Ventricular Remodeling
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Accession:DOID:9007174 term browser browse the term
Definition:The geometric and structural changes that the HEART VENTRICLES undergo, usually following MYOCARDIAL INFARCTION. It comprises expansion of the infarct and dilatation of the healthy ventricle segments. While most prevalent in the left ventricle, it can also occur in the right ventricle.
Synonyms:exact_synonym: Left Ventricle Remodeling;   Left Ventricle Remodelings;   Left Ventricular Remodeling;   Left Ventricular Remodelings;   Ventricle Remodeling;   Ventricle Remodelings;   Ventricular Cardiac Remodeling;   Ventricular Cardiac Remodelings;   Ventricular Myocardial Remodeling;   Ventricular Myocardial Remodelings;   Ventricular Remodelings
 primary_id: MESH:D020257


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Ventricular Remodeling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ace angiotensin I converting enzyme treatment IDA associated with Acute Kidney Injury RGD PMID:18223026 RGD:9685440 NCBI chr10:91,410,129...91,430,246
Ensembl chr10:91,409,819...91,430,942 		JBrowse link
G Ace2 angiotensin converting enzyme 2 treatment ISO
IEP 		associated with Diabetic Cardiomyopathies
associated with Myocardial Infarction
associated with Acute Kidney Injury 		RGD PMID:22340266 PMID:20507236 PMID:18223026 RGD:9685428, RGD:9685439, RGD:9685440 NCBI chr  X:33,925,458...33,972,851
Ensembl chr  X:33,925,458...33,971,596 		JBrowse link
G Adra1a adrenoceptor alpha 1A ISO CTD Direct Evidence: marker/mechanism CTD PMID:20668454 NCBI chr15:45,005,648...45,111,416
Ensembl chr15:45,005,799...45,102,534 		JBrowse link
G Agt angiotensinogen ISO CTD Direct Evidence: marker/mechanism CTD PMID:29353218 NCBI chr19:69,426,540...69,447,017
Ensembl chr19:69,421,638...69,446,944 		JBrowse link
G Agtr1a angiotensin II receptor, type 1a IEP RGD PMID:18252761 RGD:10047108 NCBI chr17:34,383,397...34,435,523
Ensembl chr17:34,381,467...34,435,660 		JBrowse link
G Ahr aryl hydrocarbon receptor IEP associated with diesel exhaust particulates exposure; protein:increased expression:heart left ventricle (rat) RGD PMID:23887904 RGD:401794424 NCBI chr 6:57,961,423...57,998,901
Ensembl chr 6:57,961,423...57,998,901 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 treatment IEP
ISO 		CTD Direct Evidence: therapeutic CTD
RGD		 PMID:39477182 PMID:18656339 RGD:407419882 NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:137,535,390...137,552,610 		JBrowse link
G Axin2 axin 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:29394407 NCBI chr10:94,393,379...94,426,579
Ensembl chr10:94,395,909...94,426,575 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator ameliorates ISO associated with myocardial infarction RGD PMID:25726944 RGD:11252030 NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:105,076,473...105,086,429 		JBrowse link
G Bcl2 BCL2, apoptosis regulator ameliorates ISO associated with myocardial infarction RGD PMID:25726944 RGD:11252030 NCBI chr13:23,204,464...23,366,900
Ensembl chr13:23,204,464...23,366,900 		JBrowse link
G Casp3 caspase 3 ameliorates ISO associated with myocardial infarction RGD PMID:25726944 RGD:11252030 NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732 		JBrowse link
G Ctnnb1 catenin beta 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:29394407 NCBI chr 8:129,517,576...129,544,661
Ensembl chr 8:129,517,545...129,544,662 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 IEP associated with diesel exhaust particulates exposure; protein:increased expression:heart left ventricle (rat) RGD PMID:23887904 RGD:401794424 NCBI chr 8:66,991,940...66,998,014
Ensembl chr 8:66,991,970...66,998,012 		JBrowse link
G Dstn destrin, actin depolymerizing factor ISO CTD Direct Evidence: marker/mechanism CTD PMID:29394407 NCBI chr 3:151,737,711...151,764,752
Ensembl chr 3:151,737,849...151,764,769 		JBrowse link
G Fis1 fission, mitochondrial 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20886221 NCBI chr12:25,345,239...25,360,135
Ensembl chr12:25,345,239...25,349,335 		JBrowse link
G Gata4 GATA binding protein 4 ISO CTD Direct Evidence: marker/mechanism CTD PMID:29394407 NCBI chr15:41,635,572...41,707,252
Ensembl chr15:41,635,572...41,681,609 		JBrowse link
G Gdf1 growth differentiation factor 1 ameliorates ISO associated with myocardial infarction RGD PMID:25726944 RGD:11252030 NCBI chr16:19,131,271...19,146,480
Ensembl chr16:19,131,276...19,146,480 		JBrowse link
G Gsn gelsolin ameliorates ISO RGD PMID:19246681 RGD:329333014 NCBI chr 3:38,982,605...39,035,849
Ensembl chr 3:38,982,671...39,035,850 		JBrowse link
G Hand2 heart and neural crest derivatives expressed 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:29394407 NCBI chr16:37,928,145...37,931,488
Ensembl chr16:37,928,145...37,931,488 		JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha IEP associated with diesel exhaust particulates exposure; protein:decreased expression:heart left ventricle (rat) RGD PMID:23887904 RGD:401794424 NCBI chr 6:98,357,788...98,405,068
Ensembl chr 6:98,359,910...98,405,323 		JBrowse link
G Kcnn4 potassium calcium-activated channel subfamily N member 4 ameliorates ISO associated with myocardial infarction RGD PMID:26160442 RGD:329969895 NCBI chr 1:89,084,306...89,102,279
Ensembl chr 1:89,086,814...89,102,275 		JBrowse link
G Lep leptin ISO CTD Direct Evidence: marker/mechanism CTD PMID:38906502 NCBI chr 4:58,626,529...58,640,663
Ensembl chr 4:58,626,523...58,640,661 		JBrowse link
G Ltbp2 latent transforming growth factor beta binding protein 2 ISO mRNA:increased expression:heart (mouse) RGD PMID:31364721 RGD:213230159 NCBI chr 6:104,429,947...104,530,498
Ensembl chr 6:110,161,029...110,257,298 		JBrowse link
G Map3k5 mitogen-activated protein kinase kinase kinase 5 ISO protein:increased activity:heart: RGD PMID:14665690 RGD:10412322 NCBI chr 1:16,505,387...16,723,899
Ensembl chr 1:16,505,596...16,723,898 		JBrowse link
G Mfn2 mitofusin 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20886221 NCBI chr 5:163,587,463...163,617,363
Ensembl chr 5:163,587,463...163,618,495 		JBrowse link
G Mir140 microRNA 140 ameliorates IEP RGD PMID:28922712 RGD:329347824 NCBI chr19:52,375,293...52,375,391
Ensembl chr19:52,375,293...52,375,391 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 ISO CTD Direct Evidence: therapeutic CTD PMID:29353218 NCBI chr 3:81,001,529...81,031,165
Ensembl chr 3:81,001,529...81,029,090 		JBrowse link
G Nos1 nitric oxide synthase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16344403 NCBI chr12:44,276,011...44,456,371
Ensembl chr12:44,287,614...44,371,837 		JBrowse link
G Nppa natriuretic peptide A ameliorates ISO CTD Direct Evidence: marker/mechanism
associated with myocardial infarction 		CTD
RGD		 PMID:20886221 PMID:25726944 RGD:11252030 NCBI chr 5:163,712,184...163,713,493
Ensembl chr 5:163,712,184...163,713,493 		JBrowse link
G Nppb natriuretic peptide B ameliorates ISO CTD Direct Evidence: marker/mechanism
associated with myocardial infarction 		CTD
RGD		 PMID:29394407 PMID:25726944 RGD:11252030 NCBI chr 5:163,699,955...163,701,314
Ensembl chr 5:163,699,839...163,701,310 		JBrowse link
G Opa1 OPA1, mitochondrial dynamin like GTPase ISO CTD Direct Evidence: marker/mechanism CTD PMID:20886221 NCBI chr11:84,612,943...84,690,025
Ensembl chr11:84,615,340...84,689,955 		JBrowse link
G Rock2 Rho-associated coiled-coil containing protein kinase 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:29394407 NCBI chr 6:45,407,823...45,502,773
Ensembl chr 6:45,407,965...45,502,771 		JBrowse link
G Sirt6 sirtuin 6 ISO CTD Direct Evidence: therapeutic CTD PMID:34713381 NCBI chr 7:8,733,056...8,738,543
Ensembl chr 7:8,732,974...8,738,542 		JBrowse link
G Slc9a1 solute carrier family 9 member A1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20886221 NCBI chr 5:150,859,412...150,913,525
Ensembl chr 5:150,860,228...150,913,517 		JBrowse link
G Smad2 SMAD family member 2 ameliorates ISO CTD Direct Evidence: marker/mechanism
associated with myocardial infarction 		CTD
RGD		 PMID:16635409 PMID:25726944 RGD:11252030 NCBI chr18:72,124,792...72,193,345
Ensembl chr18:72,124,863...72,187,388 		JBrowse link
G Smad3 SMAD family member 3 ameliorates ISO CTD Direct Evidence: marker/mechanism
associated with myocardial infarction 		CTD
RGD		 PMID:16635409 PMID:25726944 RGD:11252030 NCBI chr 8:73,022,204...73,132,324
Ensembl chr 8:73,024,760...73,132,324 		JBrowse link
G Tbx20 T-box transcription factor 20 ISO CTD Direct Evidence: marker/mechanism CTD PMID:29394407 NCBI chr 8:31,475,963...31,534,051
Ensembl chr 8:31,475,963...31,534,009 		JBrowse link
G Tcf7l2 transcription factor 7 like 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:29394407 NCBI chr 1:264,791,335...264,984,225
Ensembl chr 1:264,791,335...264,984,225 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16635409 NCBI chr 1:90,324,312...90,340,627
Ensembl chr 1:90,324,046...90,340,899 		JBrowse link
G Tnnt2 troponin T2, cardiac type IEP associated with diesel exhaust particulates exposure; protein:increased expression:heart left ventricle (rat) RGD PMID:23887904 RGD:401794424 NCBI chr13:49,819,123...49,837,125
Ensembl chr13:49,822,304...49,837,125 		JBrowse link
G Vegfa vascular endothelial growth factor A IEP associated with diesel exhaust particulates exposure; protein:decreased expression:heart left ventricle (rat) RGD PMID:23887904 RGD:401794424 NCBI chr 9:22,452,854...22,468,194
Ensembl chr 9:22,439,392...22,468,194 		JBrowse link
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  disease 19167
    Pathological Conditions, Signs and Symptoms 13667
      Anatomical Pathological Conditions 2873
        Ventricular Remodeling 41
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