RGD DISEASE ONTOLOGY - ANNOTATIONS
RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term: Lung Injury
Accession: DOID:9000310
browse the term
Definition: Damage to any compartment of the lung caused by physical, chemical, or biological agents which characteristically elicit inflammatory reaction. These inflammatory reactions can either be acute and dominated by NEUTROPHILS, or chronic and dominated by LYMPHOCYTES and MACROPHAGES.
Synonyms: exact_synonym: Chronic Lung Injuries; Chronic Lung Injury; Lung Injuries; Pulmonary Injuries; Pulmonary Injury
primary_id: MESH:D055370 ; RDO:0006082
For additional species annotation, visit the
Alliance of Genome Resources .
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Ace
angiotensin I converting enzyme
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:16001071
NCBI chr10:94,170,766...94,213,831
Ensembl chr10:94,170,766...94,187,822
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Ace2
angiotensin I converting enzyme 2
ISO
CTD Direct Evidence: marker/mechanism|therapeutic
CTD
PMID:16001071 PMID:19864379 PMID:20484496
NCBI chr X:32,050,734...32,095,860
Ensembl chr X:32,049,931...32,096,016
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Ager
advanced glycosylation end product-specific receptor
IEP
associated with Hyperoxia; mRNA, protein:increased expression:lung (rat)
RGD
PMID:22093994
RGD:7245945
NCBI chr20:4,363,152...4,366,079
Ensembl chr20:4,363,152...4,366,079
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Ahr
aryl hydrocarbon receptor
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:25831079
NCBI chr 6:54,963,990...55,001,806
Ensembl chr 6:54,963,990...55,001,464
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Alb
albumin
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:30953400
NCBI chr14:19,176,275...19,191,793
Ensembl chr14:19,176,277...19,191,863
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Ccl2
C-C motif chemokine ligand 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:19762220
NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870
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Ccl3
C-C motif chemokine ligand 3
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:19762220
NCBI chr10:70,869,516...70,871,066
Ensembl chr10:70,869,513...70,871,066
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Ccl4
C-C motif chemokine ligand 4
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:19762220
NCBI chr10:70,870,926...70,886,357
Ensembl chr10:70,884,531...70,886,355
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Csf3
colony stimulating factor 3
ISO
RGD
PMID:14585735
RGD:11039441
NCBI chr10:86,616,785...86,619,160
Ensembl chr10:86,616,785...86,619,157
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Cxcr2
C-X-C motif chemokine receptor 2
IMP
RGD
PMID:15347560
RGD:7257705
NCBI chr 9:81,427,275...81,435,065
Ensembl chr 9:81,427,730...81,434,102
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Cxcr3
C-X-C motif chemokine receptor 3
ISO
RGD
PMID:17086735
RGD:5135486
NCBI chr X:71,614,346...71,616,997
Ensembl chr X:71,614,346...71,616,997
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Cyp1a1
cytochrome P450, family 1, subfamily a, polypeptide 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:24893714 PMID:25703676
NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
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Cyp1a2
cytochrome P450, family 1, subfamily a, polypeptide 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25703676
NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301
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Elf3
E74 like ETS transcription factor 3
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:21709667
NCBI chr13:52,083,873...52,088,798
Ensembl chr13:52,083,859...52,088,780
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Esr2
estrogen receptor 2
IDA
associated with Shock, Hemorrhagic
RGD
PMID:20195535
RGD:4892252
NCBI chr 6:99,163,953...99,214,711
Ensembl chr 6:99,164,357...99,214,251
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Fgf7
fibroblast growth factor 7
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:18385170
NCBI chr 3:118,315,859...118,368,464
Ensembl chr 3:118,317,761...118,366,872
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Fis1
fission, mitochondrial 1
IEP
protein:increased expression:lung (rat)
RGD
PMID:25560372
RGD:12437080
NCBI chr12:22,750,485...22,765,324
Ensembl chr12:22,750,485...22,765,308
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Foxp3
forkhead box P3
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:28630656
NCBI chr X:15,753,175...15,768,648
Ensembl chr X:15,753,175...15,768,522
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Gsr
glutathione-disulfide reductase
treatment
IEP
RGD
PMID:24479952
RGD:10401875
NCBI chr16:62,197,617...62,239,987
Ensembl chr16:62,197,617...62,241,361
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Hmox1
heme oxygenase 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:17365036
NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
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Icam1
intercellular adhesion molecule 1
treatment
ISO
associated with Bacteremia;
RGD
PMID:24891762
RGD:11354979
NCBI chr 8:22,035,287...22,047,049
Ensembl chr 8:22,035,256...22,047,059
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Igf2
insulin-like growth factor 2
IEP
RGD
PMID:9160836
RGD:5509974
NCBI chr 1:215,828,102...215,839,081
Ensembl chr 1:215,828,102...215,846,911
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Il6
interleukin 6
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:19762220
NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
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Ltf
lactotransferrin
ISO
RGD
PMID:16905637
RGD:7243109
NCBI chr 8:119,290,416...119,313,261
Ensembl chr 8:119,290,416...119,313,261
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Mme
membrane metallo-endopeptidase
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:21114838
NCBI chr 2:153,799,203...153,880,910
Ensembl chr 2:153,803,349...153,880,738
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Mt2A
metallothionein 2A
ISO
mRNA:increased expression:lung (mouse) CTD Direct Evidence: therapeutic
CTD
PMID:18528683 , PMID:17215068
RGD:6483842
NCBI chr19:11,307,966...11,308,740
Ensembl chr19:11,307,967...11,308,740
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Mtor
mechanistic target of rapamycin kinase
ISO
RGD
PMID:22483544
RGD:7245567
NCBI chr 5:165,263,813...165,373,967
Ensembl chr 5:165,263,800...165,373,967
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Nfkbia
NFKB inhibitor alpha
IEP
associated with Reperfusion Injury
RGD
PMID:19321049
RGD:10413876
NCBI chr 6:76,267,227...76,270,457
Ensembl chr 6:76,267,228...76,270,457
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Ngf
nerve growth factor
ISO
protein:increased expression:respiratory system fluid/secretion CTD Direct Evidence: therapeutic
CTD
PMID:20075049 , PMID:20075049
RGD:5144062
NCBI chr 2:204,886,158...204,939,523
Ensembl chr 2:204,886,202...204,940,453
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Ngfr
nerve growth factor receptor
ISO
RGD
PMID:17673270
RGD:5144065
NCBI chr10:83,389,828...83,408,061
Ensembl chr10:83,389,847...83,408,061
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Nqo1
NAD(P)H quinone dehydrogenase 1
IEP
associated with Diabetes Mellitus, Experimental;protein:decreased expression:lung (rat)
RGD
PMID:27888691
RGD:13442477
NCBI chr19:38,422,210...38,437,103
Ensembl chr19:38,422,164...38,437,180
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Ntrk1
neurotrophic receptor tyrosine kinase 1
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:20075049
NCBI chr 2:187,143,568...187,160,373
Ensembl chr 2:187,143,568...187,160,373
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Parp1
poly (ADP-ribose) polymerase 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:16127429
NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
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Pdgfd
platelet derived growth factor D
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25280005
NCBI chr 8:4,441,010...4,666,754
Ensembl chr 8:4,440,876...4,669,014
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Pecam1
platelet and endothelial cell adhesion molecule 1
ISO
protein:increased tyrosine phosphorylation:lung (mouse)
RGD
PMID:22806890
RGD:6771215
NCBI chr10:94,850,971...94,913,202
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Plau
plasminogen activator, urokinase
IEP
associated with Hyperoxia
RGD
PMID:19099788
RGD:4143526
NCBI chr15:3,644,296...3,650,765
Ensembl chr15:3,644,769...3,650,819
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Plaur
plasminogen activator, urokinase receptor
ISO
associated with Hyperoxia
RGD
PMID:19435793
RGD:6483820
NCBI chr 1:81,328,171...81,344,954
Ensembl chr 1:81,328,183...81,344,708
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Por
cytochrome p450 oxidoreductase
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:33033841
NCBI chr12:23,998,411...24,017,063
Ensembl chr12:23,998,411...24,046,814
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Sirt1
sirtuin 1
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:24633890
NCBI chr20:26,831,971...26,851,587
Ensembl chr20:26,833,357...26,852,199
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Slc11a2
solute carrier family 11 member 2
ISO
RGD
PMID:20336479
RGD:5688724
NCBI chr 7:142,025,812...142,062,892
Ensembl chr 7:142,025,815...142,063,212
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Tacr1
tachykinin receptor 1
ISO
RGD
PMID:17565047
RGD:5147820
NCBI chr 4:113,247,236...113,416,139
Ensembl chr 4:113,247,795...113,414,504
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Tgfa
transforming growth factor alpha
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:11919079
NCBI chr 4:117,961,877...118,045,923
Ensembl chr 4:117,962,319...118,046,344
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Tlr4
toll-like receptor 4
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:22300504
NCBI chr 5:82,587,424...82,601,056
Ensembl chr 5:82,587,420...82,601,052
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Tnc
tenascin C
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:18978301
NCBI chr 5:79,789,686...79,874,555
Ensembl chr 5:79,789,671...79,874,671
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Tnf
tumor necrosis factor
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:2518282 PMID:26243812
NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000 Ensembl chr20:5,189,390...5,192,000
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Tnfrsf1a
TNF receptor superfamily member 1A
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:10781441
NCBI chr 4:157,864,905...157,877,634
Ensembl chr 4:157,864,969...157,877,633
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Ace
angiotensin I converting enzyme
treatment
ISO
associated wit Escherichia coli Infections
RGD
PMID:29990483
RGD:40400897
NCBI chr10:94,170,766...94,213,831
Ensembl chr10:94,170,766...94,187,822
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Ace2
angiotensin I converting enzyme 2
severity treatment
ISO
CTD Direct Evidence: therapeutic associated with Escherichia coli Infections associated with avian influenza;protein:decreased expression:lung (mouse) human protein in a mouse model
CTD
PMID:27302421 , PMID:16001071 , PMID:29990483 , PMID:25391767 , PMID:16001071
RGD:32716389 , RGD:40400897 , RGD:40818412 , RGD:32716389
NCBI chr X:32,050,734...32,095,860
Ensembl chr X:32,049,931...32,096,016
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Acvr1
activin A receptor type 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:21297076
NCBI chr 3:44,432,476...44,539,680
Ensembl chr 3:44,432,471...44,522,930
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Adar
adenosine deaminase, RNA-specific
treatment
IMP
RGD
PMID:18520702
RGD:10755331
NCBI chr 2:189,045,551...189,085,448
Ensembl chr 2:189,062,443...189,083,236
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Adipoq
adiponectin, C1Q and collagen domain containing
treatment
ISO
associated with Sepsis
RGD
PMID:22156343 , PMID:23522481
RGD:5686380 , RGD:8695940
NCBI chr11:81,330,845...81,344,488
Ensembl chr11:81,330,293...81,344,488
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Adra2a
adrenoceptor alpha 2A
IEP
RGD
PMID:21542970
RGD:6480481
NCBI chr 1:274,766,283...274,769,083
Ensembl chr 1:274,766,283...274,769,081
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Ager
advanced glycosylation end product-specific receptor
IEP
associated with Hyperoxia; protein:decreased expression:bronchoalveolar lavage fluid (rat)
RGD
PMID:23576805
RGD:7244254
NCBI chr20:4,363,152...4,366,079
Ensembl chr20:4,363,152...4,366,079
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Akap12
A-kinase anchoring protein 12
IEP
mRNA,protein:increased expression:lung
RGD
PMID:23912647
RGD:14348970
NCBI chr 1:40,816,130...40,906,582
Ensembl chr 1:40,816,107...40,906,581
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Akt1
AKT serine/threonine kinase 1
severity
ISO
RGD
PMID:23904165
RGD:38676478
NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
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Alb
albumin
IDA
RGD
PMID:22592748
RGD:6483494
NCBI chr14:19,176,275...19,191,793
Ensembl chr14:19,176,277...19,191,863
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Alox15
arachidonate 15-lipoxygenase
ISO
RGD
PMID:19752233
RGD:5509626
NCBI chr10:56,953,692...56,962,145
Ensembl chr10:56,953,691...56,962,161
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Apoa1
apolipoprotein A1
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:20972769
NCBI chr 8:50,525,091...50,526,875
Ensembl chr 8:50,525,091...50,526,875
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Aqp5
aquaporin 5
IEP
associated with Disseminated Intravascular Coagulation;mRNA,protein:decreased expression:lung:
RGD
PMID:24806323
RGD:11553933
NCBI chr 7:141,249,044...141,252,576
Ensembl chr 7:141,249,044...141,252,578
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Ascl1
achaete-scute family bHLH transcription factor 1
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:20554700
NCBI chr 7:28,038,662...28,040,504
Ensembl chr 7:28,038,662...28,040,510
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Bax
BCL2 associated X, apoptosis regulator
IEP
associated with Endotoxemia
RGD
PMID:20663300
RGD:10054109
NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
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Bcl2
BCL2, apoptosis regulator
IEP
associated with Endotoxemia
RGD
PMID:20663300
RGD:10054109
NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
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C3
complement C3
treatment
IEP
RGD
PMID:22763771
RGD:11040808
NCBI chr 9:9,721,137...9,747,084
Ensembl chr 9:9,721,105...9,747,167
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Casp12
caspase 12
treatment
IEP
associated with Crush Injuries
RGD
PMID:30465396
RGD:34901874
NCBI chr 8:2,658,892...2,686,160
Ensembl chr 8:2,659,865...2,686,160
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Casp3
caspase 3
treatment
IEP
RGD
PMID:29755641
RGD:13782288
NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
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Casp8
caspase 8
treatment
IEP
RGD
PMID:29755641
RGD:13782288
NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106
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Cat
catalase
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:15612528
NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
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Cav1
caveolin 1
treatment
IEP
RGD
PMID:24919947
RGD:10045573
NCBI chr 4:44,597,123...44,630,206
Ensembl chr 4:44,597,123...44,630,200
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Ccl2
C-C motif chemokine ligand 2
IEP
mRNA, protein:increased expression:lung
RGD
PMID:21767135
RGD:6480432
NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870
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Ccl4
C-C motif chemokine ligand 4
IMP IEP ISO
mRNA, protein:increased expression:lung protein:increased expression:respiratory system fluid/secretion
RGD
PMID:10679105 , PMID:21767135 , PMID:21906407
RGD:68880 , RGD:6480432 , RGD:5683874
NCBI chr10:70,870,926...70,886,357
Ensembl chr10:70,884,531...70,886,355
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Ccr1
C-C motif chemokine receptor 1
ISO
associated with Pancreatitis
RGD
PMID:17312463
RGD:5688151
NCBI chr 8:132,996,646...133,002,201
Ensembl chr 8:132,996,649...133,002,201
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Cd36
CD36 molecule
ISO
associated with Malaria
RGD
PMID:18483551
RGD:6893505
NCBI chr 4:14,150,309...14,191,498
Ensembl chr 4:14,001,761...14,249,749
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Cxcl1
C-X-C motif chemokine ligand 1
ISO
associated with Sepsis;mRNA:increased expression:lung
RGD
PMID:10069420
RGD:5135253
NCBI chr14:18,743,678...18,745,457
Ensembl chr14:18,743,685...18,745,457
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Cxcl2
C-X-C motif chemokine ligand 2
ISO IEP
mRNA, protein:increased expression:lung CTD Direct Evidence: marker/mechanism protein:increased expression:respiratory system fluid/secretion associated with Sepsis;mRNA:increased expression:lung
CTD
PMID:27525872 , PMID:15557650 , PMID:19106808 , PMID:10069420
RGD:5135247 , RGD:5147925 , RGD:5135253
NCBI chr14:18,731,346...18,733,391
Ensembl chr14:18,731,378...18,733,391
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Cxcl6
C-X-C motif chemokine ligand 6
ISO IMP
mRNA, protein:increased expression:lung associated with Reperfusion Injury
RGD
PMID:15557650 , PMID:7814607
RGD:5135247 , RGD:5135256
NCBI chr14:18,860,201...18,920,839
Ensembl chr14:18,860,264...18,862,407
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Cxcr2
C-X-C motif chemokine receptor 2
treatment
ISO
associated with Pancreatitis
RGD
PMID:17014919
RGD:7257703
NCBI chr 9:81,427,275...81,435,065
Ensembl chr 9:81,427,730...81,434,102
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Cyp1a1
cytochrome P450, family 1, subfamily a, polypeptide 1
ISO IEP
mRNA:increased expression:lung
RGD
PMID:18367723 , PMID:16882535
RGD:5135235 , RGD:5147744
NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
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Cyp2b1
cytochrome P450, family 2, subfamily b, polypeptide 1
IEP
RGD
PMID:16882535
RGD:5147744
NCBI chr 7:99,142,431...99,183,540
Ensembl chr 7:99,142,450...99,181,783
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Cysltr1
cysteinyl leukotriene receptor 1
treatment
ISO
associated with Endotoxemia
RGD
PMID:27703200
RGD:40903067
NCBI chr X:77,671,028...77,700,491
Ensembl chr X:77,674,150...77,700,269
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Ddit3
DNA-damage inducible transcript 3
treatment
IEP
associated with Crush Injuries
RGD
PMID:30465396
RGD:34901874
NCBI chr 7:70,578,564...70,585,074
Ensembl chr 7:70,580,198...70,585,084
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Edn1
endothelin 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:16625121
NCBI chr17:22,136,814...22,143,745
Ensembl chr17:22,137,324...22,143,324
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Egfr
epidermal growth factor receptor
ISO
RGD
PMID:20935109
RGD:5131862
NCBI chr14:99,919,485...100,104,136
Ensembl chr14:99,919,485...100,098,796
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Elane
elastase, neutrophil expressed
treatment
IMP IEP
associated with Shock, Hemorrhagic; protein:increased expression:perfusate:
RGD
PMID:15257085 , PMID:17203197 , PMID:18283562
RGD:10450548 , RGD:10450587 , RGD:10450585
NCBI chr 7:12,638,320...12,640,168
Ensembl chr 7:12,638,322...12,640,232
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Ephx1
epoxide hydrolase 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:26840748
NCBI chr13:99,271,390...99,300,580
Ensembl chr13:99,271,366...99,300,579
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Ephx2
epoxide hydrolase 2
IDA
RGD
PMID:22051199
RGD:5688354
NCBI chr15:42,757,241...42,794,211
Ensembl chr15:42,757,235...42,794,279
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Ern1
endoplasmic reticulum to nucleus signaling 1
treatment
IEP
associated with Crush Injuries
RGD
PMID:30465396
RGD:34901874
NCBI chr10:94,588,555...94,682,072
Ensembl chr10:94,588,555...94,681,914
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F2
coagulation factor II
IDA
RGD
PMID:22804886
RGD:7387313
NCBI chr 3:80,529,468...80,542,993
Ensembl chr 3:80,529,428...80,543,031
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F3
coagulation factor III, tissue factor
IEP
protein:increased expression: respiratory system fluid/secretion
RGD
PMID:21964405
RGD:11341740
NCBI chr 2:225,310,686...225,322,281
Ensembl chr 2:225,310,624...225,322,272
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Fadd
Fas associated via death domain
treatment
IEP
associated with Shock, Hemorrhagic
RGD
PMID:24122010
RGD:11341811
NCBI chr 1:217,746,176...217,748,581
Ensembl chr 1:217,742,929...217,748,628
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Fas
Fas cell surface death receptor
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:11778176
NCBI chr 1:252,589,785...252,624,790
Ensembl chr 1:252,589,785...252,624,790
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Faslg
Fas ligand
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:11778176
NCBI chr13:79,696,811...79,717,581
Ensembl chr13:79,698,445...79,705,705
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Fcgr1a
Fc fragment of IgG receptor Ia
IMP
RGD
PMID:19106808
RGD:5147925
NCBI chr 2:198,430,536...198,439,453
Ensembl chr 2:198,430,530...198,458,041
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Fcgr2a
Fc fragment of IgG receptor IIa
IMP
RGD
PMID:19106808
RGD:5147925
NCBI chr13:91,146,878...91,163,691
Ensembl chr13:91,168,973...91,198,036 Ensembl chr13:91,168,973...91,198,036
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Fcgr2b
Fc fragment of IgG receptor IIb
treatment
IMP
RGD
PMID:19106808
RGD:5147925
NCBI chr13:89,329,298...89,343,916
Ensembl chr13:89,327,794...89,433,815
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Fga
fibrinogen alpha chain
IEP
protein:increased expression:blood (rat)
RGD
PMID:22804886
RGD:7387313
NCBI chr 2:181,997,562...182,013,726
Ensembl chr 2:182,006,242...182,013,763
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Flt1
Fms related receptor tyrosine kinase 1
IMP
associated with Endotoxemia
RGD
PMID:21528367
RGD:5684427
NCBI chr12:9,033,993...9,205,886
Ensembl chr12:9,034,308...9,205,905
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Gja1
gap junction protein, alpha 1
treatment
IEP
RGD
PMID:23576849
RGD:8662452
NCBI chr20:37,876,650...37,889,097
Ensembl chr20:37,876,650...37,889,089
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Got1
glutamic-oxaloacetic transaminase 1
IEP
protein:decreased expression:lung (rat)
RGD
PMID:25581610
RGD:13504847
NCBI chr 1:263,246,248...263,269,762
Ensembl chr 1:263,246,248...263,269,762
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Gsr
glutathione-disulfide reductase
IEP
RGD
PMID:7896613
RGD:7257562
NCBI chr16:62,197,617...62,239,987
Ensembl chr16:62,197,617...62,241,361
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Gzmb
granzyme B
ISO
RGD
PMID:20018616
RGD:5135517
NCBI chr15:35,413,862...35,417,293
Ensembl chr15:35,413,793...35,417,316
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Hmgb1
high mobility group box 1
treatment
IEP
associated with Endotoxemia associated with Crush Injuries associated with Burns
RGD
PMID:19766246 , PMID:30465396 , PMID:23874764
RGD:4892587 , RGD:34901874 , RGD:10402098
NCBI chr12:7,082,529...7,090,246
Ensembl chr16:37,500,017...37,502,237
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Hmgcr
3-hydroxy-3-methylglutaryl-CoA reductase
ISO
RGD
PMID:16922808
RGD:5508470
NCBI chr 2:27,480,224...27,500,654
Ensembl chr 2:27,480,226...27,500,654
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Hmox1
heme oxygenase 1
treatment
IMP IEP
associated with Reperfusion Injury
RGD
PMID:20850789 , PMID:20360627
RGD:4145326 , RGD:4140418
NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
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Hnrnpc
heterogeneous nuclear ribonucleoprotein C
ISO
protein:altered localization:lung (mouse)
RGD
PMID:19029002
RGD:10054390
NCBI chr15:28,486,605...28,517,353
Ensembl chr15:28,486,617...28,517,353
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Hspa5
heat shock protein family A (Hsp70) member 5
treatment
IEP
associated with Crush Injuries
RGD
PMID:30465396
RGD:34901874
NCBI chr 3:13,838,304...13,842,763
Ensembl chr 3:13,838,304...13,842,762
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Icam1
intercellular adhesion molecule 1
treatment
IEP ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:17973899 PMID:27525872 , PMID:20569121
RGD:8547719
NCBI chr 8:22,035,287...22,047,049
Ensembl chr 8:22,035,256...22,047,059
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Ido1
indoleamine 2,3-dioxygenase 1
treatment
ISO
RGD
PMID:25278421
RGD:39939031
NCBI chr16:72,216,326...72,228,098
Ensembl chr16:72,216,326...72,228,098
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Ifng
interferon gamma
IEP
RGD
PMID:21767135
RGD:6480432
NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419
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Il10
interleukin 10
treatment no_association
IDA ISO IEP
DNA:SNP:promoter:rs3021097 (human) DNA:SNP:promoter:-1082G>A (rs1800896) (human) associated with Reperfusion Injury;protein:increased expression:lung, plasma
RGD
PMID:23902576 , PMID:30412745 , PMID:30412745 , PMID:23801594
RGD:7364984 , RGD:14975158 , RGD:14975158 , RGD:7365008
NCBI chr13:47,738,933...47,743,392
Ensembl chr13:47,739,526...47,743,392
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Il13
interleukin 13
IEP
mRNA:increased expression:lung
RGD
PMID:15461830
RGD:4145512
NCBI chr10:38,982,909...38,985,466
Ensembl chr10:38,982,909...38,985,466
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Il17a
interleukin 17A
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:28600744
NCBI chr 9:26,841,299...26,844,786
Ensembl chr 9:26,841,299...26,844,786
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Il18
interleukin 18
treatment
IEP
associated with Myocardial Reperfusion Injury
RGD
PMID:24223666
RGD:8655952
NCBI chr 8:55,009,666...55,016,286
Ensembl chr 8:54,993,859...55,016,299
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Il1b
interleukin 1 beta
ISO IDA IEP
protein:increased expression:lung mRNA, protein:increased expression:lung protein:increased expression:serum
RGD
PMID:20153312 , PMID:22982561 , PMID:21767135 , PMID:20663306 , PMID:8613550
RGD:4142807 , RGD:7204498 , RGD:6480432 , RGD:4142531 , RGD:4143193
NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
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Il1rl1
interleukin 1 receptor-like 1
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:21352201 , PMID:21352201
RGD:5144222
NCBI chr 9:47,133,483...47,184,316
Ensembl chr 9:47,134,034...47,182,170
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Il1rn
interleukin 1 receptor antagonist
IMP IEP
mRNA:increased expression:lung
RGD
PMID:8613550 , PMID:15970097
RGD:4143193 , RGD:4143168
NCBI chr 3:1,449,778...1,468,624
Ensembl chr 3:1,452,644...1,468,614
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Il2
interleukin 2
IEP
protein:increased expression:respiratory system fluid/secretion
RGD
PMID:21767135
RGD:6480432
NCBI chr 2:123,847,150...123,851,854
Ensembl chr 2:123,847,150...123,851,854
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Il22
interleukin 22
ISO
RGD
PMID:20498020
RGD:4888524
NCBI chr 7:61,236,037...61,240,502
Ensembl chr 7:61,236,037...61,240,502
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Il4
interleukin 4
treatment
IEP
RGD
PMID:24681349
RGD:10402798
NCBI chr10:38,963,979...38,969,531
Ensembl chr10:38,963,979...38,969,531
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Il6
interleukin 6
IEP
protein:increased expression:bronchoalveolar lavage, blood, lung (rat)
RGD
PMID:19995278
RGD:11062103
NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
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Irak3
interleukin-1 receptor-associated kinase 3
ISO
mRNA, protein:increased expression:lung (mouse)
RGD
PMID:21577093
RGD:36049795
NCBI chr 7:64,922,830...64,982,224
Ensembl chr 7:64,923,615...64,982,281
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Itgb2
integrin subunit beta 2
IMP
RGD
PMID:1374449
RGD:6482199
NCBI chr20:11,777,773...11,815,647
Ensembl chr20:11,777,783...11,815,647
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Jak3
Janus kinase 3
ISO
RGD
PMID:22359619
RGD:11531100
NCBI chr16:20,107,471...20,120,678
Ensembl chr16:20,109,200...20,120,668
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Kdr
kinase insert domain receptor
IEP
associated with Endotoxemia;mRNA, protein:decreased expression:lung
RGD
PMID:21528367
RGD:5684427
NCBI chr14:34,727,677...34,787,127
Ensembl chr14:34,727,623...34,787,183
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Ltb4r2
leukotriene B4 receptor 2
severity
ISO
associated with Endotoxemia
RGD
PMID:27703200
RGD:40903067
NCBI chr15:34,446,478...34,448,220
Ensembl chr15:34,446,878...34,447,954
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Mfn1
mitofusin 1
IEP
mRNA, protein:altered expression:lung (rat)
RGD
PMID:25560372
RGD:12437080
NCBI chr 2:118,929,738...118,971,689
Ensembl chr 2:118,929,738...118,973,698
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Mfn2
mitofusin 2
IEP
mRNA, protein:increased expression:lung (rat)
RGD
PMID:25560372
RGD:12437080
NCBI chr 5:164,684,244...164,715,414
Ensembl chr 5:164,684,509...164,714,145
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Mir155
microRNA 155
treatment
ISO IMP
associated with sepsis;miRNA:increased expression:lung associated with Sepsis
RGD
PMID:30220274 , PMID:27371731 , PMID:27371731 , PMID:28125526 , PMID:31949845
RGD:21066348 , RGD:11566124 , RGD:11566124 , RGD:24922218 , RGD:21408593
NCBI chr11:24,176,603...24,176,667
Ensembl chr11:24,176,603...24,176,667
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Mir21
microRNA 21
IEP
RNA:increased expression:lung
RGD
PMID:30542412
RGD:41410885
NCBI chr10:73,902,210...73,902,301
Ensembl chr10:73,902,210...73,902,301
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Mir223
microRNA 223
severity treatment
ISO IEP
RGD
PMID:28931657 , PMID:32226458
RGD:21408568 , RGD:26884341
NCBI chr X:65,367,812...65,367,921
Ensembl chr X:65,367,812...65,367,921
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Mir330
microRNA 330
IEP
associated with Disseminated Intravascular Coagulation;RNA:increased expression:lung:
RGD
PMID:24806323
RGD:11553933
NCBI chr 1:80,092,681...80,092,777
Ensembl chr 1:80,092,681...80,092,777
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Mir96
microRNA 96
IEP
associated with Disseminated Intravascular Coagulation;RNA:increased expression:lung:
RGD
PMID:24806323
RGD:11553933
NCBI chr 4:57,463,366...57,463,471
Ensembl chr 4:57,463,366...57,463,471
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Mmp2
matrix metallopeptidase 2
IEP
RGD
PMID:23040778
RGD:13207316
NCBI chr19:15,542,771...15,570,589
Ensembl chr19:15,542,765...15,570,611
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Mmp7
matrix metallopeptidase 7
IEP
associated with Sepsis
RGD
PMID:21567117
RGD:9685338
NCBI chr 8:5,893,253...5,900,965
Ensembl chr 8:5,893,249...5,901,049
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Mmp9
matrix metallopeptidase 9
IEP
RGD
PMID:23040778
RGD:13207316
NCBI chr 3:161,413,410...161,421,473
Ensembl chr 3:161,413,298...161,421,520
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Mpo
myeloperoxidase
ISO
associated with Kidney Reperfusion Injury; protein:increased expression:lung
RGD
PMID:22092133
RGD:6909173
NCBI chr10:75,087,892...75,098,260
Ensembl chr10:75,087,892...75,098,260
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Mt1
metallothionein 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:16166738
NCBI chr19:11,301,991...11,303,007
Ensembl chr17:78,793,336...78,793,724
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Mt2A
metallothionein 2A
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:16166738
NCBI chr19:11,307,966...11,308,740
Ensembl chr19:11,307,967...11,308,740
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Mylk
myosin light chain kinase
ISO
associated with Sepsis CTD Direct Evidence: marker/mechanism
CTD
PMID:19374788 , PMID:16399953
RGD:1581052
NCBI chr11:69,013,060...69,260,039
Ensembl chr11:69,013,050...69,223,158
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Nfe2l2
nuclear factor, erythroid 2-like 2
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:24812154
NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
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Ngf
nerve growth factor
ISO
RGD
PMID:17673270
RGD:5144065
NCBI chr 2:204,886,158...204,939,523
Ensembl chr 2:204,886,202...204,940,453
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Nod2
nucleotide-binding oligomerization domain containing 2
treatment
IDA
associated with Sepsis
RGD
PMID:22575870
RGD:8547530
NCBI chr19:19,342,061...19,389,366
Ensembl chr19:19,332,594...19,377,492
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Nos2
nitric oxide synthase 2
IMP
RGD
PMID:16882535
RGD:5147744
NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
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Nppa
natriuretic peptide A
ISO
RGD
PMID:23422200
RGD:7247713
NCBI chr 5:164,808,407...164,809,716
Ensembl chr 5:164,808,323...164,809,705
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Nqo1
NAD(P)H quinone dehydrogenase 1
treatment
IEP IDA
RGD
PMID:24669282 , PMID:28065220
RGD:11035223 , RGD:13442501
NCBI chr19:38,422,210...38,437,103
Ensembl chr19:38,422,164...38,437,180
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Opa1
OPA1, mitochondrial dynamin like GTPase
IEP
mRNA, protein:altered expression:lung (rat)
RGD
PMID:25560372
RGD:12437080
NCBI chr11:74,717,600...74,793,902
Ensembl chr11:74,720,254...74,793,803
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P2ry12
purinergic receptor P2Y12
IMP
associated with Shock, Hemorrhagic
RGD
PMID:21841533
RGD:6480522
NCBI chr 2:149,440,807...149,482,592
Ensembl chr 2:149,441,598...149,444,548
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Pak1
p21 (RAC1) activated kinase 1
IDA
DNA:hypermethylation
RGD
PMID:23546543
RGD:11533951
NCBI chr 1:162,768,156...162,883,356
Ensembl chr 1:162,768,156...162,883,355
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Parp1
poly (ADP-ribose) polymerase 1
ISO
associated with Pancreatitis, Experimental, Acute
RGD
PMID:16127429
RGD:11075069
NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
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Pawr
pro-apoptotic WT1 regulator
IEP
mRNA,protein:increased expression:lung,blood vessel:
RGD
PMID:17136598
RGD:9835397
NCBI chr 7:51,273,764...51,353,700
Ensembl chr 7:51,273,771...51,353,068
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Pecam1
platelet and endothelial cell adhesion molecule 1
IDA
RGD
PMID:22592748
RGD:6483494
NCBI chr10:94,850,971...94,913,202
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Pfkfb3
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
ISO
associated with Endotoxemia;mRNA, protein:increased expression:lung (mouse)
RGD
PMID:31167111
RGD:41410778
NCBI chr17:70,632,778...70,713,736
Ensembl chr17:70,684,134...70,713,726
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Pik3cg
phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma
ISO
associated with endotoxemia
RGD
PMID:22198681 , PMID:11714830
RGD:6482677 , RGD:38599213
NCBI chr 6:51,465,696...51,501,234
Ensembl chr 6:51,465,908...51,498,337
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Pla2g2a
phospholipase A2 group IIA
severity
IEP
RGD
PMID:19235614
RGD:6482722
NCBI chr 5:157,282,650...157,285,295
Ensembl chr 5:157,282,669...157,285,328
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Plau
plasminogen activator, urokinase
treatment
IDA
associated with Endotoxemia
RGD
PMID:21473829 , PMID:23324284
RGD:5147760 , RGD:7241552
NCBI chr15:3,644,296...3,650,765
Ensembl chr15:3,644,769...3,650,819
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Pparg
peroxisome proliferator-activated receptor gamma
IEP ISO
protein:decreased expression:lung (rat) CTD Direct Evidence: therapeutic
CTD
PMID:21153920 , PMID:16083301
RGD:8553030
NCBI chr 4:147,274,055...147,399,383
Ensembl chr 4:147,274,107...147,399,380
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Prkaa1
protein kinase AMP-activated catalytic subunit alpha 1
ISO
RGD
PMID:21595935
RGD:6484539
NCBI chr 2:54,857,688...54,893,404
Ensembl chr 2:54,857,688...54,893,404
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Proc
protein C, inactivator of coagulation factors Va and VIIIa
treatment
ISO
associated with Pseudomonas Infections associated with Intestinal Reperfusion Injury
RGD
PMID:16553944 , PMID:18367148
RGD:11100043 , RGD:11250405
NCBI chr18:24,918,402...24,928,822
Ensembl chr18:24,918,398...24,929,091
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Procr
protein C receptor
treatment
IEP
RGD
PMID:20095324
RGD:13515130
NCBI chr 3:151,285,321...151,289,581
Ensembl chr 3:151,285,249...151,289,595
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Ptgs2
prostaglandin-endoperoxide synthase 2
ISO IEP
protein:increased expression:lung
RGD
PMID:20926798 , PMID:19567182
RGD:5135287 , RGD:5135496
NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
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Scgb1a1
secretoglobin family 1A member 1
IEP ISO
protein:decreased expression:lung
RGD
PMID:18420837 , PMID:16226776
RGD:5143982 , RGD:5144142
NCBI chr 1:225,279,698...225,283,246
Ensembl chr 1:225,279,676...225,283,326
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Serpinc1
serpin family C member 1
treatment
ISO
associated with Endotoxemia
RGD
PMID:17940748
RGD:11035256
NCBI chr13:78,806,107...78,820,375
Ensembl chr13:78,805,347...78,833,192
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Serpine1
serpin family E member 1
treatment
IDA IEP
associated with Shock, Hemorrhagic;mRNA:increased expression:lung (rat) associated with Sepsis
RGD
PMID:25934465 , PMID:10745022 , PMID:18182560
RGD:11075078 , RGD:11080967 , RGD:11080962
NCBI chr12:22,641,104...22,651,482
Ensembl chr12:22,641,104...22,651,482
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Serping1
serpin family G member 1
treatment
ISO
RGD
PMID:11685347
RGD:8661650
NCBI chr 3:72,161,230...72,171,109
Ensembl chr 3:72,161,189...72,171,078
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Sftpa1
surfactant protein A1
ISO
mRNA, protein:increased expression:pneumocyte
RGD
PMID:8569184
RGD:4143451
NCBI chr16:18,716,019...18,719,404
Ensembl chr16:18,716,019...18,719,403
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Sftpd
surfactant protein D
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:30060251
NCBI chr16:18,753,535...18,766,100
Ensembl chr16:18,745,458...18,766,174
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Slpi
secretory leukocyte peptidase inhibitor
severity treatment
IMP IEP
associated with Endotoxemia
RGD
PMID:10092827 , PMID:25466948
RGD:9999422 , RGD:9999425
NCBI chr 3:160,799,979...160,802,228
Ensembl chr 3:160,799,981...160,802,433
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Tac1
tachykinin, precursor 1
ISO
RGD
PMID:19797759
RGD:5147812
NCBI chr 4:33,638,853...33,646,819
Ensembl chr 4:33,638,709...33,646,819
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Tacr1
tachykinin receptor 1
ISO
mRNA:increased expression:lung
RGD
PMID:18523300
RGD:5147819
NCBI chr 4:113,247,236...113,416,139
Ensembl chr 4:113,247,795...113,414,504
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Tff1
trefoil factor 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:19880587
NCBI chr20:9,892,124...9,895,984
Ensembl chr20:9,892,124...9,895,984
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Tff2
trefoil factor 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:19880587
NCBI chr20:9,872,669...9,876,008
Ensembl chr20:9,872,680...9,876,008
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Tgfb1
transforming growth factor, beta 1
treatment
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:16100012 , PMID:25278421
RGD:39939031
NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199
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Thbd
thrombomodulin
treatment
ISO IEP
associated with Endotoxemia
RGD
PMID:19342415 , PMID:20095324 , PMID:19536047
RGD:5131887 , RGD:13515130 , RGD:5685372
NCBI chr 3:142,748,673...142,752,325
Ensembl chr 3:142,748,674...142,752,325
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Timp2
TIMP metallopeptidase inhibitor 2
severity
IMP
RGD
PMID:10092827
RGD:9999422
NCBI chr10:107,338,465...107,386,072
Ensembl chr10:107,338,465...107,386,072
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Tlr4
toll-like receptor 4
IEP
RGD
PMID:19567182
RGD:5135496
NCBI chr 5:82,587,424...82,601,056
Ensembl chr 5:82,587,420...82,601,052
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Tnf
tumor necrosis factor
treatment no_association
IEP ISO
mRNA, protein:increased expression:lung associated with Liver Reperfusion Injury DNA:SNP:promoter:rs1799964 (human) DNA:SNP:promoter:-308G>A (rs1800629) (human) protein:increased expression:respiratory system fluid/secretion
RGD
PMID:21767135 , PMID:11129814 , PMID:30412745 , PMID:30412745 , PMID:19106808
RGD:6480432 , RGD:14995473 , RGD:14975158 , RGD:14975158 , RGD:5147925
NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000 Ensembl chr20:5,189,390...5,192,000
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Tnfaip6
TNF alpha induced protein 6
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:26313688
NCBI chr 3:37,545,238...37,564,704
Ensembl chr 3:37,545,238...37,564,699
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Txn1
thioredoxin 1
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:16298680
NCBI chr 5:75,049,735...75,057,731
Ensembl chr 5:75,049,747...75,057,752
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Vegfa
vascular endothelial growth factor A
IEP
associated with Endotoxemia;mRNA, protein:altered expression:lung, plasma
RGD
PMID:21528367
RGD:5684427
NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681
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Vip
vasoactive intestinal peptide
IDA ISO
associated with Endotoxemia CTD Direct Evidence: therapeutic
CTD
PMID:8643465 , PMID:20441697
RGD:4145303
NCBI chr 1:42,169,307...42,177,582
Ensembl chr 1:42,169,501...42,177,582
G
Xdh
xanthine dehydrogenase
treatment
IEP
RGD
PMID:9655743
RGD:13209002
NCBI chr 6:25,149,570...25,211,273
Ensembl chr 6:25,149,235...25,211,494
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Zc3h12a
zinc finger CCCH type containing 12A
severity
ISO
associated with toxic shock syndrome
RGD
PMID:23422584
RGD:39938961
NCBI chr 5:143,111,342...143,120,131
Ensembl chr 5:143,111,074...143,120,165
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Atp1a4
ATPase Na+/K+ transporting subunit alpha 4
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:29394417
NCBI chr13:90,605,792...90,642,032
Ensembl chr13:90,605,794...90,641,772
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Flacc1
flagellum associated containing coiled-coil domains 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:29394417
NCBI chr 9:65,665,663...65,693,822
Ensembl chr 9:65,665,664...65,693,822
G
Il1a
interleukin 1 alpha
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:20005085
NCBI chr 3:121,824,712...121,836,122
Ensembl chr 3:121,825,412...121,836,086
G
Il1b
interleukin 1 beta
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:20005085
NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
G
Il1rn
interleukin 1 receptor antagonist
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:20005085
NCBI chr 3:1,449,778...1,468,624
Ensembl chr 3:1,452,644...1,468,614
G
Rbm26
RNA binding motif protein 26
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:29394417
NCBI chr15:89,262,683...89,339,323
Ensembl chr15:89,266,710...89,339,323
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Tnf
tumor necrosis factor
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:20005085
NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000 Ensembl chr20:5,189,390...5,192,000
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Arg1
arginase 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:26699812
NCBI chr 1:21,525,421...21,537,872
Ensembl chr 1:21,525,421...21,537,863
G
Atf6
activating transcription factor 6
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25324550
NCBI chr13:89,053,457...89,242,531
Ensembl chr13:89,055,983...89,242,443
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Cfd
complement factor D
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:22832039
NCBI chr 7:12,634,216...12,635,939
Ensembl chr 7:12,634,216...12,635,943
G
Clca1
chloride channel accessory 1
ISO
mRNA, protein:increased expression:lung
RGD
PMID:17637221
RGD:4145655
NCBI chr 2:250,897,980...250,923,711
Ensembl chr 2:250,897,969...250,923,744
G
Cyp2e1
cytochrome P450, family 2, subfamily e, polypeptide 1
ISO
mRNA:decreased expression:leukocyte
RGD
PMID:20514434
RGD:4892076
NCBI chr 1:213,511,892...213,522,195
Ensembl chr 1:213,511,874...213,535,542
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Ddit3
DNA-damage inducible transcript 3
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25324550
NCBI chr 7:70,578,564...70,585,074
Ensembl chr 7:70,580,198...70,585,084
G
Ephx1
epoxide hydrolase 1
susceptibility
ISO
DNA:SNP:exon:p.Y113H (rs1051740) (human)
RGD
PMID:17159790
RGD:4889408
NCBI chr13:99,271,390...99,300,580
Ensembl chr13:99,271,366...99,300,579
G
Gstm1
glutathione S-transferase mu 1
susceptibility
ISO
DNA:deletion: :
RGD
PMID:9055949
RGD:5490588
NCBI chr 2:210,803,869...210,809,461
Ensembl chr 2:210,803,869...210,809,306
G
Gstt1
glutathione S-transferase theta 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:17563610
NCBI chr20:13,799,102...13,816,527
Ensembl chr20:13,799,102...13,816,526
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Hspa5
heat shock protein family A (Hsp70) member 5
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25324550
NCBI chr 3:13,838,304...13,842,763
Ensembl chr 3:13,838,304...13,842,762
G
Il1b
interleukin 1 beta
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:8473757
NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
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Nlrp3
NLR family, pyrin domain containing 3
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:24142982
NCBI chr10:45,884,324...45,918,290
Ensembl chr10:45,893,018...45,918,254
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Nos2
nitric oxide synthase 2
ISO IEP
CTD Direct Evidence: marker/mechanism mRNA,protein:increased expression:lung
CTD
PMID:12160931 , PMID:12160931 , PMID:12051993
RGD:4891441 , RGD:4891438
NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
G
Prdx1
peroxiredoxin 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:22537621
NCBI chr 5:135,536,413...135,551,986
Ensembl chr 5:135,536,413...135,551,990
G
Prdx2
peroxiredoxin 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:22537621
NCBI chr19:26,084,816...26,090,095
Ensembl chr19:26,084,903...26,090,094
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Serpina1
serpin family A member 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:12368052
NCBI chr 6:127,610,241...127,632,265
Ensembl chr 6:127,610,243...127,632,265
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Spp1
secreted phosphoprotein 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:16221779 PMID:21514415
NCBI chr14:6,673,686...6,679,965
Ensembl chr14:6,673,686...6,679,901
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Tnc
tenascin C
ISO
protein:increased expression:pleura
RGD
PMID:10950882
RGD:4889594
NCBI chr 5:79,789,686...79,874,555
Ensembl chr 5:79,789,671...79,874,671
G
Tnf
tumor necrosis factor
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:8473757 PMID:20486865
NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000 Ensembl chr20:5,189,390...5,192,000
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Tpm4
tropomyosin 4
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:22537621
NCBI chr16:19,385,810...19,399,851
Ensembl chr16:19,385,736...19,399,903
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Ace
angiotensin I converting enzyme
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:10194187
NCBI chr10:94,170,766...94,213,831
Ensembl chr10:94,170,766...94,187,822
G
Btnl2
butyrophilin-like 2
susceptibility
ISO
DNA:SNP: :rs3117099(human) CTD Direct Evidence: marker/mechanism
CTD
PMID:17927685 , PMID:17927685
RGD:9685029
NCBI chr20:4,140,184...4,156,365
Ensembl chr20:4,141,878...4,154,978
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Ccr5
C-C motif chemokine receptor 5
disease_progression
ISO
DNA:polymorphisms:5' utr:multiple (human)
RGD
PMID:20075058
RGD:4892065
NCBI chr 8:133,192,398...133,215,599
Ensembl chr 8:133,197,032...133,215,614
G
Cd28
Cd28 molecule
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:12952926
NCBI chr 9:67,546,408...67,573,858
Ensembl chr 9:67,546,408...67,571,871
G
Gclm
glutamate cysteine ligase, modifier subunit
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:16766924
NCBI chr 2:225,827,504...225,847,876
Ensembl chr 2:225,827,504...225,847,874
G
Hmox1
heme oxygenase 1
ISO
protein:increased activity:sputum
RGD
PMID:19453654
RGD:4145349
NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
G
Il2ra
interleukin 2 receptor subunit alpha
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:8977230
NCBI chr17:70,500,672...70,547,929
Ensembl chr17:70,499,083...70,548,071
G
Il6
interleukin 6
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:8428540
NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
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RT1-Db1
RT1 class II, locus Db1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:16272364 PMID:17927685
NCBI chr20:4,087,621...4,097,190
Ensembl chr20:4,087,618...4,097,190
G
Tgfb1
transforming growth factor, beta 1
severity
ISO
DNA:polymorphisms: :-509C>T (human) CTD Direct Evidence: marker/mechanism
CTD
PMID:15750822 PMID:17785866 , PMID:17785866
RGD:4145294
NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199
G
Tnf
tumor necrosis factor
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:8428540 PMID:12449171 PMID:15127972 PMID:16980557
NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000 Ensembl chr20:5,189,390...5,192,000
G
Bax
BCL2 associated X, apoptosis regulator
IEP
RGD
PMID:26431790
RGD:11537057
NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
G
Bid
BH3 interacting domain death agonist
IEP
RGD
PMID:26431790
RGD:11537057
NCBI chr 4:153,439,812...153,465,247
Ensembl chr 4:153,442,218...153,465,203
G
Casp3
caspase 3
IEP
RGD
PMID:26431790
RGD:11537057
NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
G
Casp8
caspase 8
IEP
RGD
PMID:26431790
RGD:11537057
NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106
G
Casp9
caspase 9
IEP
RGD
PMID:26431790
RGD:11537057
NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
G
Cat
catalase
IDA
RGD
PMID:19693467
RGD:5130750
NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
G
Ccl7
C-C motif chemokine ligand 7
ISO
RGD
PMID:16888287
RGD:5130981
NCBI chr10:69,423,083...69,424,933
Ensembl chr10:69,423,086...69,424,979
G
Cd209
CD209 molecule
ISO
RGD
PMID:20050784
RGD:5131185
NCBI chr12:2,406,879...2,413,324
Ensembl chr12:2,406,879...2,413,324
G
Cd209c
CD209c molecule
ISO
RGD
PMID:20050784
RGD:5131185
NCBI chr12:2,837,991...2,846,709
Ensembl chr12:2,838,128...2,843,772
G
Chi3l1
chitinase 3 like 1
ISO
protein:decreased secretion:lung, secretion (human)
RGD
PMID:20558631
RGD:4892651
NCBI chr13:51,022,844...51,030,797
Ensembl chr13:51,022,681...51,030,802
G
Cxcl1
C-X-C motif chemokine ligand 1
IEP
RGD
PMID:19951473
RGD:5134972
NCBI chr14:18,743,678...18,745,457
Ensembl chr14:18,743,685...18,745,457
G
Dag1
dystroglycan 1
ISO
DNA:SNP: :p.N494H (human)
RGD
PMID:17196572
RGD:11537474
NCBI chr 8:116,980,501...116,993,182
Ensembl chr 8:116,980,497...116,993,193
G
Edn1
endothelin 1
IEP
protein:increased expression:lung (rat)
RGD
PMID:20647310
RGD:4144841
NCBI chr17:22,136,814...22,143,745
Ensembl chr17:22,137,324...22,143,324
G
Epas1
endothelial PAS domain protein 1
treatment
IEP
RGD
PMID:23065129
RGD:10395385
NCBI chr 6:10,306,508...10,385,239
Ensembl chr 6:10,306,405...10,387,265
G
Flt1
Fms related receptor tyrosine kinase 1
ISO
RGD
PMID:22003089
RGD:10402122
NCBI chr12:9,033,993...9,205,886
Ensembl chr12:9,034,308...9,205,905
G
Gstm1
glutathione S-transferase mu 1
susceptibility
ISO
DNA:deletion, haplotype:: (human)
RGD
PMID:24120392
RGD:12792215
NCBI chr 2:210,803,869...210,809,461
Ensembl chr 2:210,803,869...210,809,306
G
Gstp1
glutathione S-transferase pi 1
susceptibility
ISO
DNA:polymorphism:exon:p.I105V (human)
RGD
PMID:14726935
RGD:4142520
NCBI chr 1:219,291,679...219,294,147
Ensembl chr 1:219,291,679...219,294,147
G
Gstt1
glutathione S-transferase theta 1
susceptibility
ISO
DNA:deletion, haplotype:: (human)
RGD
PMID:24120392
RGD:12792215
NCBI chr20:13,799,102...13,816,527
Ensembl chr20:13,799,102...13,816,526
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Hif1a
hypoxia inducible factor 1 subunit alpha
treatment
IEP
RGD
PMID:23065129 , PMID:26431790
RGD:10395385 , RGD:11537057
NCBI chr 6:96,810,868...96,856,303
Ensembl chr 6:96,810,907...96,856,052
G
Il1b
interleukin 1 beta
ISO
protein:increased expression:lung CTD Direct Evidence: marker/mechanism
CTD
PMID:16813970 , PMID:15539764
RGD:4143172
NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
G
Il1rn
interleukin 1 receptor antagonist
susceptibility
ISO
protein:increased expression:lung associated with Premature Birth;DNA:polymorphism::
RGD
PMID:15539764 , PMID:22882323
RGD:4143172 , RGD:12910846
NCBI chr 3:1,449,778...1,468,624
Ensembl chr 3:1,452,644...1,468,614
G
Mbl2
mannose binding lectin 2
susceptibility
ISO
associated with Premature Birth;DNA:polymorphism:exon:
RGD
PMID:22882323
RGD:12910846
NCBI chr 1:248,435,069...248,442,669
Ensembl chr 1:248,723,397...248,729,962
G
Mif
macrophage migration inhibitory factor
ISO
associated with Respiratory Distress Syndrome, Newborn; protein:increased expression:lung
RGD
PMID:18097062
RGD:4891007
NCBI chr20:13,715,219...13,732,980
Ensembl chr20:13,732,198...13,732,859
G
Mmp9
matrix metallopeptidase 9
ISO
RGD
PMID:19097983
RGD:5129685
NCBI chr 3:161,413,410...161,421,473
Ensembl chr 3:161,413,298...161,421,520
G
Muc1
mucin 1, cell surface associated
severity
ISO
protein:increased expression:cord plasma
RGD
PMID:18025794
RGD:5131170
NCBI chr 2:188,543,137...188,547,874
Ensembl chr 2:188,543,137...188,547,874
G
Postn
periostin
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:22363622
NCBI chr 2:143,656,820...143,688,087
Ensembl chr 2:143,656,793...143,688,087
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Scgb1a1
secretoglobin family 1A member 1
ISO
RGD
PMID:11435254
RGD:5144211
NCBI chr 1:225,279,698...225,283,246
Ensembl chr 1:225,279,676...225,283,326
G
Serpine1
serpin family E member 1
ISO
associated with Premature Birth;protein:increased expression:blood:
RGD
PMID:25140773
RGD:13208551
NCBI chr12:22,641,104...22,651,482
Ensembl chr12:22,641,104...22,651,482
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Sftpa1
surfactant protein A1
susceptibility
ISO
DNA:snps, haplotypes:multiple (human) DNA:polymorphisms, haplotype: (human)
RGD
PMID:17264398 , PMID:11105614
RGD:4143384 , RGD:4144876
NCBI chr16:18,716,019...18,719,404
Ensembl chr16:18,716,019...18,719,403
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Sftpb
surfactant protein B
susceptibility
ISO
DNA:deletion:intron (human) DNA:polymorphism:intron (human)
RGD
PMID:15102713 , PMID:17264398 , PMID:12424586
RGD:4143405 , RGD:4143384 , RGD:4143418
NCBI chr 4:100,166,855...100,175,941
Ensembl chr 4:100,166,863...100,175,938
G
Sftpd
surfactant protein D
ISO
RGD
PMID:17264398
RGD:4143384
NCBI chr16:18,753,535...18,766,100
Ensembl chr16:18,745,458...18,766,174
G
Tnf
tumor necrosis factor
severity no_association
ISO
DNA:SNP:promoter:-238A>G (human) DNA:SNP:promoter:-308G>A (human)
RGD
PMID:15286263 , PMID:15286263
RGD:12904049 , RGD:12904049
NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000 Ensembl chr20:5,189,390...5,192,000
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Tp53
tumor protein p53
IEP
RGD
PMID:26431790
RGD:11537057
NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
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Txn1
thioredoxin 1
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:20812253
NCBI chr 5:75,049,735...75,057,731
Ensembl chr 5:75,049,747...75,057,752
G
Vdr
vitamin D receptor
susceptibility
ISO
associated with Premature Birth;DNA:SNPs: :rs2228570,rs731236(human)
RGD
PMID:24796371
RGD:13432055
NCBI chr 7:139,344,452...139,394,138
Ensembl chr 7:139,342,063...139,394,166
G
Epas1
endothelial PAS domain protein 1
IEP
mRNA:increased expression:lung
RGD
PMID:22305384
RGD:10395369
NCBI chr 6:10,306,508...10,385,239
Ensembl chr 6:10,306,405...10,387,265
G
Cyp1a1
cytochrome P450, family 1, subfamily a, polypeptide 1
treatment
IDA ISO
RGD
PMID:15958656 , PMID:21745492 , PMID:24893714
RGD:4892072 , RGD:11576318 , RGD:11576306
NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
G
Elane
elastase, neutrophil expressed
treatment
IMP
RGD
PMID:11104832
RGD:10450581
NCBI chr 7:12,638,320...12,640,168
Ensembl chr 7:12,638,322...12,640,232
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Fgf2
fibroblast growth factor 2
IMP
RGD
PMID:12626345
RGD:11567262
NCBI chr 2:124,081,072...124,134,133
Ensembl chr 2:124,081,072...124,134,681
G
Hmox1
heme oxygenase 1
treatment
IEP
RGD
PMID:23475767
RGD:10755753
NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
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Mir21
microRNA 21
exacerbates ameliorates
IMP IDA
RGD
PMID:28627345 , PMID:31537223
RGD:41404708 , RGD:41404709
NCBI chr10:73,902,210...73,902,301
Ensembl chr10:73,902,210...73,902,301
G
Mmp9
matrix metallopeptidase 9
treatment
ISO
RGD
PMID:25760549
RGD:13204816
NCBI chr 3:161,413,410...161,421,473
Ensembl chr 3:161,413,298...161,421,520
G
Nqo1
NAD(P)H quinone dehydrogenase 1
ISO
RGD
PMID:16678022
RGD:10769360
NCBI chr19:38,422,210...38,437,103
Ensembl chr19:38,422,164...38,437,180
G
Nqo2
N-ribosyldihydronicotinamide:quinone reductase 2
ISO
RGD
PMID:16678022
RGD:10769360
NCBI chr17:32,131,847...32,158,559
Ensembl chr17:32,132,347...32,158,538
G
Pdgfb
platelet derived growth factor subunit B
IEP
mRNA:increased expression:lung:
RGD
PMID:2696512
RGD:10449500
NCBI chr 7:121,215,458...121,233,092
Ensembl chr 7:121,214,628...121,232,741
G
Ptch1
patched 1
IEP
mRNA, protein:increased expression:lung
RGD
PMID:22641469
RGD:12859031
NCBI chr17:1,032,242...1,085,885
Ensembl chr17:1,029,048...1,093,873
G
Shh
sonic hedgehog signaling molecule
IEP
mRNA, protein:increased expression:lung
RGD
PMID:22641469
RGD:12859031
NCBI chr 4:718,538...727,691
Ensembl chr 4:718,538...727,691
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Xdh
xanthine dehydrogenase
IEP
RGD
PMID:2549869
RGD:13209004
NCBI chr 6:25,149,570...25,211,273
Ensembl chr 6:25,149,235...25,211,494
G
Fam189a1
family with sequence similarity 189, member A1
ISO
ClinVar Annotator: match by term: Lung damage, immunodeficiency and chromosome breakage syndrome
ClinVar
PMID:20864041 PMID:27427983
NCBI chr 1:125,552,990...125,967,984
Ensembl chr 1:125,553,439...125,967,756
G
Nsmce3
NSE3 homolog, SMC5-SMC6 complex component
ISO
ClinVar Annotator: match by term: Lung disease, immunodeficiency, and chromosome breakage syndrome
ClinVar OMIM
PMID:20864041 PMID:27427983
NCBI chr 1:125,663,987...125,665,314
G
Bax
BCL2 associated X, apoptosis regulator
treatment
IEP
RGD
PMID:23953793
RGD:10054119
NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
G
Bcl2
BCL2, apoptosis regulator
treatment
IEP
RGD
PMID:23953793
RGD:10054119
NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
G
Casp3
caspase 3
treatment
IEP
RGD
PMID:23953793
RGD:10054119
NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
G
Egr1
early growth response 1
treatment
IMP IEP
RGD
PMID:22878149 , PMID:23232597
RGD:10395282 , RGD:10395299
NCBI chr18:27,657,903...27,660,101
Ensembl chr18:27,657,628...27,661,429
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Elane
elastase, neutrophil expressed
treatment
IMP
RGD
PMID:17888675
RGD:10450582
NCBI chr 7:12,638,320...12,640,168
Ensembl chr 7:12,638,322...12,640,232
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Hmgb1
high mobility group box 1
IEP
protein:increased expression:lung
RGD
PMID:22115333
RGD:10402095
NCBI chr12:7,082,529...7,090,246
Ensembl chr16:37,500,017...37,502,237
G
Hmox1
heme oxygenase 1
IEP
protein:increased expression:lung
RGD
PMID:21227458
RGD:10755577
NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
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Icam1
intercellular adhesion molecule 1
treatment
IEP
RGD
PMID:22503847
RGD:7240537
NCBI chr 8:22,035,287...22,047,049
Ensembl chr 8:22,035,256...22,047,059
G
Il1b
interleukin 1 beta
IDA IEP
protein:increased expression:lung (rat)
RGD
PMID:23142117 , PMID:23122581
RGD:7183185 , RGD:7204125
NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
G
Il4
interleukin 4
treatment
IDA
RGD
PMID:24365768
RGD:10402797
NCBI chr10:38,963,979...38,969,531
Ensembl chr10:38,963,979...38,969,531
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Mmp9
matrix metallopeptidase 9
IEP
protein:increased activity:lung
RGD
PMID:18694576
RGD:5129703
NCBI chr 3:161,413,410...161,421,473
Ensembl chr 3:161,413,298...161,421,520
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Myc
MYC proto-oncogene, bHLH transcription factor
treatment
IEP
RGD
PMID:22503847
RGD:7240537
NCBI chr 7:102,586,313...102,591,240
Ensembl chr 7:102,586,313...102,591,240
G
Nos3
nitric oxide synthase 3
IMP ISO
mRNA:increased expression:lung (mouse)
RGD
PMID:20815765 , PMID:25382268
RGD:4892012 , RGD:11533932
NCBI chr 4:7,321,908...7,342,404
Ensembl chr 4:7,320,668...7,342,410
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Nqo1
NAD(P)H quinone dehydrogenase 1
treatment
IEP
RGD
PMID:21781312
RGD:6771212
NCBI chr19:38,422,210...38,437,103
Ensembl chr19:38,422,164...38,437,180
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Pecam1
platelet and endothelial cell adhesion molecule 1
IDA IEP
protein:increased expression:alveolar macrophage (rat)
RGD
PMID:21781312 , PMID:16449942
RGD:6771212 , RGD:11541083
NCBI chr10:94,850,971...94,913,202
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Proc
protein C, inactivator of coagulation factors Va and VIIIa
treatment
ISO
RGD
PMID:19782612
RGD:11100035
NCBI chr18:24,918,402...24,928,822
Ensembl chr18:24,918,398...24,929,091
G
Serpine1
serpin family E member 1
treatment
ISO IDA
protein:increased expression:plasma (human)
RGD
PMID:17846288 , PMID:11606484
RGD:8547720 , RGD:11080966
NCBI chr12:22,641,104...22,651,482
Ensembl chr12:22,641,104...22,651,482
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Tlr4
toll-like receptor 4
treatment
IEP
RGD
PMID:22115333
RGD:10402095
NCBI chr 5:82,587,424...82,601,056
Ensembl chr 5:82,587,420...82,601,052
G
Tnf
tumor necrosis factor
IMP
RGD
PMID:17294835
RGD:4143397
NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000 Ensembl chr20:5,189,390...5,192,000
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Agt
angiotensinogen
IEP
mRNA:increased expression:lung
RGD
PMID:14605247
RGD:11039054
NCBI chr19:57,321,594...57,333,460
Ensembl chr19:57,321,640...57,333,433
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Agtr2
angiotensin II receptor, type 2
treatment
IMP
RGD
PMID:14605247
RGD:11039054
NCBI chr X:119,389,480...119,393,845
Ensembl chr X:119,390,013...119,393,842
G
Atf2
activating transcription factor 2
ISS
MouseDO
NCBI chr 3:60,721,137...60,795,951
Ensembl chr 3:60,721,135...60,795,951
G
Scgb1a1
secretoglobin family 1A member 1
ISO
protein:increased expression:broncho-alveolar lavage fluid, meconium
RGD
PMID:21567110
RGD:5144123
NCBI chr 1:225,279,698...225,283,246
Ensembl chr 1:225,279,676...225,283,326
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Acan
aggrecan
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25445010
NCBI chr 1:140,762,758...140,824,441
Ensembl chr 1:140,762,758...140,824,441
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Atr
ATR serine/threonine kinase
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25445010
NCBI chr 8:103,673,578...103,770,886
Ensembl chr 8:103,673,411...103,770,947
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Ca3
carbonic anhydrase 3
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25445010
NCBI chr 2:88,126,519...88,136,063
Ensembl chr 2:88,126,667...88,135,410
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Car1
carbonic anhydrase 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25445010
NCBI chr 2:88,185,204...88,227,486
Ensembl chr 2:88,217,188...88,227,479
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Cat
catalase
ISO
protein:increased expression:respiratory system fluid/secretion
RGD
PMID:19273541
RGD:5130756
NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
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Cdh23
cadherin-related 23
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25445010
NCBI chr20:29,857,018...30,263,758
Ensembl chr20:29,857,637...29,990,111
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H3f4
H3.4 histone
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25445010
NCBI chr10:45,304,696...45,305,106
G
Hs3st6
heparan sulfate-glucosamine 3-sulfotransferase 6
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25445010
NCBI chr10:14,122,856...14,128,984
Ensembl chr10:14,122,878...14,128,983
G
Il27ra
interleukin 27 receptor subunit alpha
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25445010
NCBI chr19:25,151,835...25,163,995
Ensembl chr19:25,149,897...25,164,086
G
Il4
interleukin 4
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:21857939
NCBI chr10:38,963,979...38,969,531
Ensembl chr10:38,963,979...38,969,531
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Mdm4
MDM4 regulator of p53
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25445010
NCBI chr13:49,786,776...49,828,780
Ensembl chr13:49,792,794...49,828,720
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Ptprz1
protein tyrosine phosphatase, receptor type Z1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25445010
NCBI chr 4:49,941,046...50,140,764
Ensembl chr 4:49,941,304...50,140,762
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RT1-Bb
RT1 class II, locus Bb
susceptibility
ISO
DNA:polymorphisms:cds:HLA-DQB1*06, HLA-DQB1*08, HLA-DQB1*09 (human)
RGD
PMID:16188098
RGD:7421557
NCBI chr20:4,043,726...4,049,367
Ensembl chr20:4,039,413...4,049,711
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Ticam1
toll-like receptor adaptor molecule 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25445010
NCBI chr 9:10,780,185...10,790,280
G
Tmprss3
transmembrane serine protease 3
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25445010
NCBI chr20:9,910,522...9,929,705
Ensembl chr20:9,910,522...9,929,705
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Gc
GC, vitamin D binding protein
ISO
protein:increased expression:bronchoalveolar fluid:
RGD
PMID:21136918
RGD:5509873
NCBI chr14:20,267,023...20,302,577
Ensembl chr14:20,266,891...20,302,581
G
Ccl2
C-C motif chemokine ligand 2
IEP
protein:increased expression:alveolar system (rat)
RGD
PMID:16044083
RGD:11060268
NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870
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Il6
interleukin 6
IEP
protein:increased expression:bronchoalveolar lavage fluid (rat)
RGD
PMID:16044083
RGD:11060268
NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
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Alox5
arachidonate 5-lipoxygenase
IMP
RGD
PMID:1886988
RGD:4890434
NCBI chr 4:148,398,004...148,446,308
Ensembl chr 4:148,398,892...148,446,303
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C3
complement C3
ISO
Protein: increased expression: plasma
RGD
PMID:20510197
RGD:5129484
NCBI chr 9:9,721,137...9,747,084
Ensembl chr 9:9,721,105...9,747,167
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C4bpa
complement component 4 binding protein, alpha
ISO
Protein: increased expression: plasma
RGD
PMID:20510197
RGD:5129484
NCBI chr13:47,342,090...47,377,580
Ensembl chr13:47,342,079...47,377,703
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Ccl17
C-C motif chemokine ligand 17
IEP
mRNA, protein:increased expression:lung, alveolar macrophage
RGD
PMID:15293604
RGD:4145517
NCBI chr19:10,619,220...10,620,671
Ensembl chr19:10,619,220...10,620,671
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Ccl22
C-C motif chemokine ligand 22
IEP
mRNA, protein:increased expression:lung, alveolar macrophage
RGD
PMID:15293604
RGD:4145517
NCBI chr19:10,674,189...10,681,145
Ensembl chr19:10,674,189...10,681,145
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Il13
interleukin 13
susceptibility
ISO
associated with carcinoma, non-small-cell lung; DNA:SNPs: :rs20541, rs180925 (human)
RGD
PMID:20811626
RGD:5131286
NCBI chr10:38,982,909...38,985,466
Ensembl chr10:38,982,909...38,985,466
G
Il1a
interleukin 1 alpha
susceptibility
ISO
associated with carcinoma, non-small-cell lung: DNA:SNPs: :rs1800587,rs17561(human)
RGD
PMID:20811626
RGD:5131286
NCBI chr 3:121,824,712...121,836,122
Ensembl chr 3:121,825,412...121,836,086
G
Mif
macrophage migration inhibitory factor
susceptibility
ISO
associated with carcinoma, non-small-cell lung; DNA:SNP: :rs755622(human)
RGD
PMID:20811626
RGD:5131286
NCBI chr20:13,715,219...13,732,980
Ensembl chr20:13,732,198...13,732,859
G
Nos3
nitric oxide synthase 3
susceptibility
ISO
associated with carcinoma, non-small-cell lung;DNA:SNP:cds:c.894G>T rs1799983 (human)
RGD
PMID:20811626
RGD:5131286
NCBI chr 4:7,321,908...7,342,404
Ensembl chr 4:7,320,668...7,342,410
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Sftpd
surfactant protein D
susceptibility
ISO
RGD
PMID:20459699
RGD:4143486
NCBI chr16:18,753,535...18,766,100
Ensembl chr16:18,745,458...18,766,174
G
Tgfb1
transforming growth factor, beta 1
susceptibility
ISO IMP
protein:increased expression:blood DNA:SNP:exon:869T>C (rs1982073) (human)
RGD
PMID:19943923 , PMID:18411002 , PMID:19380441
RGD:4145121 , RGD:4145278 , RGD:4145136
NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199
G
Tnf
tumor necrosis factor
susceptibility
ISO
associated with carcinoma, non-small-cell lung: DNA:SNPs: :rs1799724(human)
RGD
PMID:20811626
RGD:5131286
NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000 Ensembl chr20:5,189,390...5,192,000
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Tnfrsf1a
TNF receptor superfamily member 1A
ISO
RGD
PMID:18347190
RGD:5131153
NCBI chr 4:157,864,905...157,877,634
Ensembl chr 4:157,864,969...157,877,633
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Vtn
vitronectin
ISO
Protein: increased expression: plasma
RGD
PMID:20510197
RGD:5129484
NCBI chr10:65,767,960...65,771,040
Ensembl chr10:65,767,053...65,771,038
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Ahr
aryl hydrocarbon receptor
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:22273745
NCBI chr 6:54,963,990...55,001,806
Ensembl chr 6:54,963,990...55,001,464
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Arg1
arginase 1
IEP ISO
mRNA:increased expression:lung (rat) CTD Direct Evidence: marker/mechanism
CTD
PMID:15292275 , PMID:17365572
RGD:4143368
NCBI chr 1:21,525,421...21,537,872
Ensembl chr 1:21,525,421...21,537,863
G
Arpc2
actin related protein 2/3 complex, subunit 2
IEP
mRNA:altered expression:lung (rat)
RGD
PMID:18685790
RGD:4893904
NCBI chr 9:81,518,163...81,548,871
Ensembl chr 9:81,518,176...81,548,871
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C3
complement C3
ISO
DNA:polymorphism (human)
RGD
PMID:12096683
RGD:5129516
NCBI chr 9:9,721,137...9,747,084
Ensembl chr 9:9,721,105...9,747,167
G
Ccl2
C-C motif chemokine ligand 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:26163174
NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870
G
Ccl7
C-C motif chemokine ligand 7
IEP
RGD
PMID:21830856
RGD:6483764
NCBI chr10:69,423,083...69,424,933
Ensembl chr10:69,423,086...69,424,979
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Cd36
CD36 molecule
treatment
IMP
RGD
PMID:24053919
RGD:11041147
NCBI chr 4:14,150,309...14,191,498
Ensembl chr 4:14,001,761...14,249,749
G
Chia
chitinase, acidic
IEP
mRNA:increased expression:lung (rat)
RGD
PMID:18685790
RGD:4893904
NCBI chr 2:208,750,348...208,797,388
Ensembl chr 2:208,749,996...208,797,402
G
Cpm
carboxypeptidase M
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:24986923
NCBI chr 7:60,654,350...60,714,620
Ensembl chr 7:60,654,350...60,714,620
G
Csf2
colony stimulating factor 2
IEP
protein:increased expression:serum:
RGD
PMID:21505002
RGD:10450467
NCBI chr10:39,602,089...39,604,070
Ensembl chr10:39,602,089...39,604,070
G
Ctla4
cytotoxic T-lymphocyte-associated protein 4
ISO
RGD
PMID:16831302
RGD:4891515
NCBI chr 9:67,699,397...67,706,068
Ensembl chr 9:67,699,379...67,706,065
G
Egr1
early growth response 1
IEP
protein:increased expression:lung, epithelial cell, macrophage (rat)
RGD
PMID:15033019
RGD:5131937
NCBI chr18:27,657,903...27,660,101
Ensembl chr18:27,657,628...27,661,429
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Eln
elastin
IEP
protein:increased expression:lung connective tissue:
RGD
PMID:7573374
RGD:9585691
NCBI chr12:24,978,478...25,021,864
Ensembl chr12:24,978,483...25,021,863
G
Hmox1
heme oxygenase 1
ISO
protein:increased expression:serum, lung
RGD
PMID:16858012
RGD:4145384
NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
G
Hnrnpa3
heterogeneous nuclear ribonucleoprotein A3
IEP
protein:increased expression:lung
RGD
PMID:19534998
RGD:10059658
NCBI chr 3:62,481,222...62,491,356
Ensembl chr 3:62,481,323...62,487,227
G
Il17a
interleukin 17A
ISO
mRNA, protein:increased expression:lung
RGD
PMID:20421647
RGD:4888525
NCBI chr 9:26,841,299...26,844,786
Ensembl chr 9:26,841,299...26,844,786
G
Il1b
interleukin 1 beta
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:23640035
NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
G
Il1rn
interleukin 1 receptor antagonist
susceptibility treatment
ISO IDA
DNA:SNP (human)
RGD
PMID:11264025 , PMID:23842733
RGD:4142816 , RGD:8551847
NCBI chr 3:1,449,778...1,468,624
Ensembl chr 3:1,452,644...1,468,614
G
Il2ra
interleukin 2 receptor subunit alpha
ISO
RGD
PMID:21072213
RGD:4891500
NCBI chr17:70,500,672...70,547,929
Ensembl chr17:70,499,083...70,548,071
G
Jun
Jun proto-oncogene, AP-1 transcription factor subunit
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:27621875
NCBI chr 5:114,011,184...114,014,277
Ensembl chr 5:114,011,189...114,014,277
G
Marco
macrophage receptor with collagenous structure
treatment
IMP
RGD
PMID:30391304
RGD:41412200
NCBI chr16:85,115,199...85,147,683
Ensembl chr16:85,115,201...85,135,859
G
Mmp13
matrix metallopeptidase 13
IEP
mRNA:increased expression:lung, fibroblast
RGD
PMID:9614183
RGD:10043156
NCBI chr 8:5,522,739...5,533,018
Ensembl chr 8:5,522,739...5,533,018
G
Nos2
nitric oxide synthase 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:15292275 , PMID:15205031
RGD:4891445
NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
G
Pdzrn4
PDZ domain containing RING finger 4
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:24986923
NCBI chr 7:133,856,101...134,004,250
Ensembl chr 7:133,856,101...134,004,250
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Prkcb
protein kinase C, beta
IDA
protein:increased activation:alveolar macrophage
RGD
PMID:14680365
RGD:1625527
NCBI chr 1:192,233,569...192,575,339
Ensembl chr 1:192,233,910...192,574,831
G
Pten
phosphatase and tensin homolog
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:27621875
NCBI chr 1:251,421,814...251,487,634
Ensembl chr 1:251,421,596...251,487,832
G
RT1-Bb
RT1 class II, locus Bb
ISO
DNA:polymorphism: :HLA-DQB1*0402(human)
RGD
PMID:11776400
RGD:36049758
NCBI chr20:4,043,726...4,049,367
Ensembl chr20:4,039,413...4,049,711
G
Tnf
tumor necrosis factor
treatment
ISO IEP
DNA:polymorphisms: :
RGD
PMID:11264025 , PMID:25199287
RGD:4142816 , RGD:10450591
NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000 Ensembl chr20:5,189,390...5,192,000
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Tnfrsf1a
TNF receptor superfamily member 1A
ISO
RGD
PMID:11208652
RGD:5131150
NCBI chr 4:157,864,905...157,877,634
Ensembl chr 4:157,864,969...157,877,633
G
Tnfrsf1b
TNF receptor superfamily member 1B
ISO
RGD
PMID:11208652
RGD:5131150
NCBI chr 5:163,136,390...163,167,299
Ensembl chr 5:163,136,390...163,167,299
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Sting1
stimulator of interferon response cGAMP interactor 1
severity
ISO
RGD
PMID:31141689
RGD:39128194
NCBI chr18:28,529,537...28,535,828
Ensembl chr18:28,529,576...28,535,828
G
Akt1
AKT serine/threonine kinase 1
ISO
RGD
PMID:19124556
RGD:5509080
NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
G
Atp1a2
ATPase Na+/K+ transporting subunit alpha 2
IMP
RGD
PMID:18424620
RGD:6903342
NCBI chr13:90,651,682...90,676,629
Ensembl chr13:90,651,686...90,676,629
G
Elane
elastase, neutrophil expressed
ISO
RGD
PMID:18276796
RGD:10450549
NCBI chr 7:12,638,320...12,640,168
Ensembl chr 7:12,638,322...12,640,232
G
Gadd45a
growth arrest and DNA-damage-inducible, alpha
ISO
RGD
PMID:19124556
RGD:5509080
NCBI chr 4:97,782,512...97,784,814
Ensembl chr 4:97,782,512...97,784,842
G
Hmgb1
high mobility group box 1
treatment
IMP
associated with Endotoxemia
RGD
PMID:24058610
RGD:10402091
NCBI chr12:7,082,529...7,090,246
Ensembl chr16:37,500,017...37,502,237
G
Il10
interleukin 10
treatment
IDA
RGD
PMID:23890086 , PMID:22106021
RGD:7364989 , RGD:11049495
NCBI chr13:47,738,933...47,743,392
Ensembl chr13:47,739,526...47,743,392
G
Il1b
interleukin 1 beta
ISO IDA IMP
protein:increased expression:lung
RGD
PMID:20574227 , PMID:22007788 , PMID:20452617
RGD:4142534 , RGD:6482672 , RGD:4142537
NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
G
Il1r1
interleukin 1 receptor type 1
ISO
RGD
PMID:17901159
RGD:2311107
NCBI chr 9:46,962,291...47,038,139
Ensembl chr 9:46,962,288...47,036,670
G
Il1rn
interleukin 1 receptor antagonist
IEP
mRNA:increased expression:lung (rat)
RGD
PMID:22782699
RGD:6909178
NCBI chr 3:1,449,778...1,468,624
Ensembl chr 3:1,452,644...1,468,614
G
Il22
interleukin 22
ISO
RGD
PMID:20463292
RGD:5147406
NCBI chr 7:61,236,037...61,240,502
Ensembl chr 7:61,236,037...61,240,502
G
Map3k5
mitogen-activated protein kinase kinase kinase 5
IEP
protein:hyperphosphorylation:lung:
RGD
PMID:24126891
RGD:10412643
NCBI chr 1:15,412,603...15,613,752
Ensembl chr 1:15,412,603...15,613,746
G
Mmp7
matrix metallopeptidase 7
IEP
RGD
PMID:21567117 , PMID:21935365
RGD:9685338 , RGD:9685370
NCBI chr 8:5,893,253...5,900,965
Ensembl chr 8:5,893,249...5,901,049
G
Mmp9
matrix metallopeptidase 9
ISO
RGD
PMID:18223162
RGD:5130156
NCBI chr 3:161,413,410...161,421,473
Ensembl chr 3:161,413,298...161,421,520
G
Nfkbia
NFKB inhibitor alpha
IEP
RGD
PMID:20199666
RGD:10413863
NCBI chr 6:76,267,227...76,270,457
Ensembl chr 6:76,267,228...76,270,457
G
Pik3cg
phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma
ISO
RGD
PMID:16374167
RGD:6482697
NCBI chr 6:51,465,696...51,501,234
Ensembl chr 6:51,465,908...51,498,337
G
Ptgs2
prostaglandin-endoperoxide synthase 2
IMP
RGD
PMID:21048090
RGD:5134956
NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
G
Scgb1a1
secretoglobin family 1A member 1
ISO
RGD
PMID:15608088
RGD:5144143
NCBI chr 1:225,279,698...225,283,246
Ensembl chr 1:225,279,676...225,283,326
G
Serpine1
serpin family E member 1
IEP
associated with Pneumonia, Pneumococcal;protein:increased expression:bronchoalveolar lavage fluid (rat)
RGD
PMID:18768578
RGD:11081010
NCBI chr12:22,641,104...22,651,482
Ensembl chr12:22,641,104...22,651,482
G
Tacr1
tachykinin receptor 1
IMP
RGD
PMID:20176632
RGD:5147811
NCBI chr 4:113,247,236...113,416,139
Ensembl chr 4:113,247,795...113,414,504
Term paths to the root one shortest all shortest one longest all longest one shortest and longest all