Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Behavioral & Substance Use Disorder Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)

RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:Hodgkin's lymphoma
go back to main search page
Accession:DOID:8567 term browser browse the term
Definition:A lymphoma that is marked by the presence of a type of cell called the Reed-Sternberg cell. (DO)
Synonyms:exact_synonym: CHL;   HL;   Hodgkin disease;   Hodgkin lymphoma;   Hodgkin's Disease;   Hodgkin's sarcoma;   Hodgkins Disease;   Hodgkins Lymphoma;   LYMPHOMA, HODGKIN, CLASSIC;   Lymphocyte Depletion Hodgkin's Lymphoma;   Lymphocyte Rich Classical Hodgkin's Lymphoma;   Malignant Granuloma;   Malignant Granulomas;   malignant lymphogranuloma;   malignant lymphogranulomas;   nodular lymphocyte predominant Hodgkin's lymphoma;   nodular sclerosing Hodgkin's lymphoma
 narrow_synonym: Splenic Hodgkin Lymphoma;   adult Hodgkin lymphoma;   classical Hodgkin's lymphoma;   stage I subdiaphragmatic Hodgkin lymphoma;   stage II subdiaphragmatic Hodgkin lymphoma
 broad_synonym: KLHDC8B-related condition
 xref: EFO:0000183;   EFO:0000346;   EFO:1000548;   GARD:2714;   ICD10CM:C81;   ICD9CM:201;   MESH:D006689;   MIM:236000;   MONDO:0004952;   NCI:C9357;   ORDO:98293
For additional species annotation, visit the Alliance of Genome Resources.


show annotations for term's descendants           Sort by:
Hodgkin's lymphoma term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd40 CD40 molecule ISO CTD Direct Evidence: marker/mechanism CTD PMID:7621881 NCBI chr 3:174,209,113...174,224,592
Ensembl chr 3:174,209,719...174,224,847 		JBrowse link
G Cd40lg CD40 ligand ISO CTD Direct Evidence: marker/mechanism CTD PMID:7621881 PMID:8656679 NCBI chr  X:140,164,341...140,176,057
Ensembl chr  X:140,164,302...140,176,475 		JBrowse link
G Cd68 Cd68 molecule severity ISO associated with Epstein-Barr Virus Infections;protein:increased expression:tumor(human)
protein:increased expression:tumor (human) 		RGD PMID:21071500 PMID:23045593 RGD:40925944, RGD:40925946 NCBI chr10:54,880,562...54,882,441
Ensembl chr10:54,880,563...54,882,540 		JBrowse link
G Cflar CASP8 and FADD-like apoptosis regulator ISO CTD Direct Evidence: marker/mechanism CTD PMID:17659339 NCBI chr 9:67,679,502...67,747,226
Ensembl chr 9:67,679,559...67,726,434 		JBrowse link
G Csf3 colony stimulating factor 3 ISO CTD Direct Evidence: therapeutic CTD PMID:17562247 NCBI chr10:84,157,485...84,159,860
Ensembl chr10:84,157,211...84,159,860 		JBrowse link
G Fgfr3 fibroblast growth factor receptor 3 ISO ClinVar Annotator: match by term: Classic Hodgkin lymphoma ClinVar PMID:28492532 PMID:32934698 NCBI chr14:81,211,800...81,227,215
Ensembl chr14:81,211,800...81,227,209 		JBrowse link
G Fgfr4 fibroblast growth factor receptor 4 ISO ClinVar Annotator: match by term: Classic Hodgkin lymphoma ClinVar PMID:32934698 NCBI chr17:9,466,686...9,481,423
Ensembl chr17:9,466,692...9,481,389 		JBrowse link
G Gata3 GATA binding protein 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:21037568 NCBI chr17:73,544,234...73,575,670
Ensembl chr17:73,553,548...73,575,670 		JBrowse link
G Gstm1 glutathione S-transferase mu 1 disease_progression ISO RGD PMID:21916526 RGD:10450802 NCBI chr 2:198,338,005...198,346,007
Ensembl chr 2:198,338,008...198,343,569 		JBrowse link
G Gstp1 glutathione S-transferase pi 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:11406608 NCBI chr 1:210,767,237...210,770,242
Ensembl chr 1:210,767,237...210,769,705 		JBrowse link
G Gstt1 glutathione S-transferase theta 1 disease_progression ISO RGD PMID:21916526 RGD:10450802 NCBI chr20:12,856,068...12,873,020
Ensembl chr20:12,856,083...12,873,019 		JBrowse link
G Icam1 intercellular adhesion molecule 1 ISO protein:increased expression:serum:
CTD Direct Evidence: marker/mechanism 		CTD
RGD		 PMID:7621881 PMID:8656679 PMID:7686390 RGD:11520780 NCBI chr 8:27,829,688...27,841,618
Ensembl chr 8:27,829,161...27,841,617 		JBrowse link
G Il10 interleukin 10 treatment ISO RGD PMID:21466366 RGD:11049168 NCBI chr13:45,024,921...45,029,586
Ensembl chr13:45,025,087...45,029,580 		JBrowse link
G Il6 interleukin 6 treatment ISO DNA:SNPs: :multiple RGD PMID:19573080 PMID:21466366 RGD:11049165, RGD:11049168 NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610 		JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit ISO RGD PMID:12145210 RGD:1549449 NCBI chr 5:115,009,900...115,012,993
Ensembl chr 5:114,973,151...115,013,285 		JBrowse link
G Junb JunB proto-oncogene, AP-1 transcription factor subunit ISO RGD PMID:12145210 RGD:1549449 NCBI chr19:40,081,126...40,082,910
Ensembl chr19:40,073,541...40,085,218 		JBrowse link
G Klhdc8b kelch domain containing 8B susceptibility ISO CTD Direct Evidence: marker/mechanism
ClinVar Annotator: match by term: Classic Hodgkin lymphoma | ClinVar Annotator: match by term: KLHDC8B-related condition 		OMIM
CTD
ClinVar		 PMID:19706467 PMID:25741868 PMID:28492532 NCBI chr 8:118,020,136...118,025,102
Ensembl chr 8:118,020,376...118,025,102 		JBrowse link
G Kras KRAS proto-oncogene, GTPase ISO ClinVar Annotator: match by term: Classic Hodgkin lymphoma ClinVar PMID:20147967 PMID:20570890 PMID:25251940 PMID:25741868 PMID:26110767 More... NCBI chr 4:179,916,255...179,949,613
Ensembl chr 4:179,919,802...179,949,320 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:7545087 NCBI chr11:97,462,025...97,529,193
Ensembl chr11:97,462,025...97,527,825 		JBrowse link
G Met MET proto-oncogene, receptor tyrosine kinase ISO ClinVar Annotator: match by term: Classic Hodgkin lymphoma ClinVar PMID:14559814 PMID:21970370 PMID:22703879 PMID:23806086 PMID:24088041 More... NCBI chr 4:46,756,823...46,864,041
Ensembl chr 4:46,756,506...46,870,821 		JBrowse link
G Mthfd2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase ISO CTD Direct Evidence: marker/mechanism CTD PMID:24688052 NCBI chr 4:117,368,833...117,380,350
Ensembl chr 4:117,368,835...117,380,350 		JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor ISO ClinVar Annotator: match by term: Classic Hodgkin lymphoma ClinVar PMID:25741868 PMID:32934698 NCBI chr 7:95,483,105...95,488,031
Ensembl chr 7:95,483,105...95,488,028 		JBrowse link
G Nfkbia NFKB inhibitor alpha ISO CTD Direct Evidence: marker/mechanism CTD
RGD		 PMID:19223558 PMID:10340377 PMID:10556199 RGD:2298893, RGD:2298894 NCBI chr 6:78,593,844...78,597,307
Ensembl chr 6:78,593,847...78,597,072 		JBrowse link
G Pramex1 PRAME like, X-linked 1 severity ISO mRNA:increased expression:lymphoid tissue (human) RGD PMID:26044287 RGD:11060455 NCBI chr  X:102,862,457...102,867,725
Ensembl chr  X:102,861,881...102,870,708 		JBrowse link
G Ptpn1 protein tyrosine phosphatase, non-receptor type 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:24531327 NCBI chr 3:177,056,588...177,106,424
Ensembl chr 3:177,057,659...177,106,416 		JBrowse link
G Pvt1 Pvt1 oncogene ISO CTD Direct Evidence: marker/mechanism CTD PMID:21037568 NCBI chr 7:95,545,916...95,769,306 JBrowse link
G Rel REL proto-oncogene, NF-kB subunit ISO CTD Direct Evidence: marker/mechanism CTD PMID:21037568 NCBI chr14:101,891,238...101,922,324
Ensembl chr14:101,891,243...101,921,938 		JBrowse link
G Sdc1 syndecan 1 ISO protein:altered expression:tumor (human) RGD PMID:9746758 RGD:9743928 NCBI chr 6:37,282,041...37,304,503
Ensembl chr 6:37,297,010...37,304,500 		JBrowse link
G Tnfrsf8 TNF receptor superfamily member 8 ISO CTD Direct Evidence: marker/mechanism CTD PMID:7621881 PMID:8701986 PMID:10908157 PMID:12358914 PMID:12453859 More... NCBI chr 5:162,406,387...162,451,620
Ensembl chr 5:162,406,387...162,451,620 		JBrowse link
G Tnfsf8 TNF superfamily member 8 ISO CTD Direct Evidence: marker/mechanism CTD PMID:7621881 PMID:8656679 PMID:8701986 PMID:8896393 PMID:9058727 More... NCBI chr 5:82,266,436...82,292,858
Ensembl chr 5:82,266,436...82,292,858 		JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18768784 NCBI chr 9:96,249,143...96,256,264
Ensembl chr 9:96,144,786...96,256,264 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 19167
    disease of cellular proliferation 7905
      Neoplasms by Histologic Type 5351
        lymphoma 580
          Hodgkin's lymphoma 31
            Hodgkin Disease, X-Linked Pseudoautosomal 0
            Hodgkin Disease, Y-Linked Pseudoautosomal 0
            Hodgkin's granuloma 0
            Hodgkin's lymphoma, lymphocytic depletion 0
            Hodgkin's lymphoma, lymphocytic-histiocytic predominance 0
            Hodgkin's lymphoma, mixed cellularity 0
            Hodgkin's lymphoma, nodular sclerosis 0
            Hodgkin's paragranuloma 0
Path 2
Term Annotations click to browse term
  disease 19167
    disease of anatomical entity 18473
      Immune & Inflammatory Diseases 5781
        immune system disease 5094
          lymphatic system disease 1751
            lymphatic system cancer 664
              lymphoma 580
                Hodgkin's lymphoma 31
                  Hodgkin Disease, X-Linked Pseudoautosomal 0
                  Hodgkin Disease, Y-Linked Pseudoautosomal 0
                  Hodgkin's granuloma 0
                  Hodgkin's lymphoma, lymphocytic depletion 0
                  Hodgkin's lymphoma, lymphocytic-histiocytic predominance 0
                  Hodgkin's lymphoma, mixed cellularity 0
                  Hodgkin's lymphoma, nodular sclerosis 0
                  Hodgkin's paragranuloma 0
paths to the root