RGD DISEASE ONTOLOGY - ANNOTATIONS
RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term: Hypotension
Accession: DOID:9006024
browse the term
Definition: Abnormally low BLOOD PRESSURE that can result in inadequate blood flow to the brain and other vital organs. Common symptom is DIZZINESS but greater negative impacts on the body occur when there is prolonged depravation of oxygen and nutrients.
Synonyms: exact_synonym: Low Blood Pressure; Vascular Hypotension
primary_id: MESH:D007022 ; RDO:0005869
For additional species annotation, visit the
Alliance of Genome Resources .
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Ace
angiotensin I converting enzyme
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:3544871
NCBI chr10:94,170,766...94,213,831
Ensembl chr10:94,170,766...94,187,822
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Adk
adenosine kinase
IMP
RGD
PMID:9435554
RGD:6482668
NCBI chr15:3,033,535...3,435,888
Ensembl chr15:3,033,495...3,435,888
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Adora1
adenosine A1 receptor
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:15641640 PMID:18313046
NCBI chr13:51,042,111...51,076,913
Ensembl chr13:51,042,248...51,076,852
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Adora2a
adenosine A2a receptor
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:1592228 PMID:15641640 PMID:18313046
NCBI chr20:14,265,251...14,282,873
Ensembl chr20:14,265,252...14,282,873
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Adra1a
adrenoceptor alpha 1A
IDA
RGD
PMID:12433595
RGD:1625780
NCBI chr15:43,296,997...43,398,314
Ensembl chr15:43,298,794...43,392,451
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Adra1b
adrenoceptor alpha 1B
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:11278430
NCBI chr10:29,392,762...29,450,644
Ensembl chr10:29,392,762...29,450,644
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Adra2a
adrenoceptor alpha 2A
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:16595736 PMID:18849358
NCBI chr 1:274,766,283...274,769,083
Ensembl chr 1:274,766,283...274,769,081
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Agt
angiotensinogen
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:3078272 PMID:8527259 PMID:9323291 , PMID:9466969
RGD:737778
NCBI chr19:57,321,594...57,333,460
Ensembl chr19:57,321,640...57,333,433
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Akr1c1
aldo-keto reductase family 1, member C1
ISO
ClinVar Annotator: match by term: Hypotension
ClinVar
PMID:28492532
NCBI chr17:69,441,253...69,460,334
Ensembl chr17:69,441,223...69,460,321
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Alb
albumin
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:4463119 PMID:11229087
NCBI chr14:19,176,275...19,191,793
Ensembl chr14:19,176,277...19,191,863
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Avp
arginine vasopressin
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:2485266 PMID:3544871 PMID:11171655 PMID:12019395 PMID:17357383
NCBI chr 3:123,117,482...123,119,460
Ensembl chr 3:123,117,492...123,119,460
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Bdkrb2
bradykinin receptor B2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:1334354 PMID:16321614 , PMID:9039147
RGD:4891024
NCBI chr 6:129,399,468...129,429,676
Ensembl chr 6:129,399,468...129,429,676
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Bnc2
basonuclin 2
ISO
ClinVar Annotator: match by term: Hypotension
ClinVar
PMID:24033266 PMID:28492532
NCBI chr 5:102,407,508...102,807,389
Ensembl chr 5:102,415,847...102,786,331
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Cat
catalase
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:15612528
NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
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Cnr1
cannabinoid receptor 1
IMP ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:9888857 , PMID:19295473
RGD:2314676
NCBI chr 5:49,307,584...49,333,064
Ensembl chr 5:49,311,030...49,333,056
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Crh
corticotropin releasing hormone
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:1320258 PMID:6093200
NCBI chr 2:104,459,999...104,461,863
Ensembl chr 2:104,459,999...104,461,863
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Crhr2
corticotropin releasing hormone receptor 2
IDA
RGD
PMID:11036160
RGD:1581302
NCBI chr 4:85,286,371...85,329,374
Ensembl chr 4:85,286,372...85,329,362
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Ctf1
cardiotrophin 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:11304496
NCBI chr 1:199,162,319...199,168,296
Ensembl chr 1:199,163,086...199,168,296
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Dbh
dopamine beta-hydroxylase
ISO
RGD
PMID:12969876
RGD:5129693
NCBI chr 3:5,709,236...5,731,895
Ensembl chr 3:5,709,236...5,731,898
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Drd1
dopamine receptor D1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:1724532 PMID:12946566
NCBI chr17:11,099,736...11,104,352
Ensembl chr17:11,101,306...11,103,541
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Drd2
dopamine receptor D2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:1724532 PMID:9917201 PMID:10626749 PMID:12946566
NCBI chr 8:53,678,777...53,743,643
Ensembl chr 8:53,678,777...53,743,642
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Edn1
endothelin 1
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:1309933 PMID:10399635 , PMID:20516397
RGD:4144881
NCBI chr17:22,136,814...22,143,745
Ensembl chr17:22,137,324...22,143,324
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Edn2
endothelin 2
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:1309933
NCBI chr 5:139,098,472...139,106,396
Ensembl chr 5:139,100,898...139,105,792
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Edn3
endothelin 3
ISO
CTD Direct Evidence: marker/mechanism|therapeutic
CTD
PMID:1309933 PMID:7982458
NCBI chr 3:172,856,730...172,879,276
Ensembl chr 3:172,856,733...172,880,450
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Fgf1
fibroblast growth factor 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:9233905
NCBI chr18:32,273,830...32,359,831
Ensembl chr18:32,273,770...32,359,824
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Gcg
glucagon
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:3277781 PMID:8517581
NCBI chr 3:48,442,635...48,451,650
Ensembl chr 3:48,442,635...48,451,650
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Gria1
glutamate ionotropic receptor AMPA type subunit 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:18639534
NCBI chr10:42,441,723...42,760,200
Ensembl chr10:42,614,713...42,760,200
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Grin2b
glutamate ionotropic receptor NMDA type subunit 2B
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:18639534
NCBI chr 4:169,541,620...170,000,216
Ensembl chr 4:169,560,387...169,999,873
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Gstm1
glutathione S-transferase mu 1
IEP
mRNA:increased expression:kidney (rat)
RGD
PMID:15942020
RGD:1625563
NCBI chr 2:210,803,869...210,809,461
Ensembl chr 2:210,803,869...210,809,306
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Hrh1
histamine receptor H 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:2105067
NCBI chr 4:146,374,596...146,458,148
Ensembl chr 4:146,455,332...146,457,074
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Htr1b
5-hydroxytryptamine receptor 1B
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:9109356
NCBI chr 8:89,113,984...89,130,830
Ensembl chr 8:89,129,453...89,130,991
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Htr1d
5-hydroxytryptamine receptor 1D
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:9109356
NCBI chr 5:154,780,958...154,801,505
Ensembl chr 5:154,800,226...154,801,350
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Ifng
interferon gamma
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:3091246
NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419
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Il1a
interleukin 1 alpha
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:15384034
NCBI chr 3:121,824,712...121,836,122
Ensembl chr 3:121,825,412...121,836,086
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Il1b
interleukin 1 beta
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:1884014 PMID:15384034
NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
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Il2
interleukin 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:8635092
NCBI chr 2:123,847,150...123,851,854
Ensembl chr 2:123,847,150...123,851,854
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Il6
interleukin 6
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:15217654 PMID:15384034
NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
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Ins2
insulin 2
ISO
CTD Direct Evidence: marker/mechanism|therapeutic
CTD
PMID:48835 PMID:1324617 PMID:7418494
NCBI chr 1:215,856,967...215,858,034
Ensembl chr 1:215,856,971...215,858,034
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Klf6
Kruppel-like factor 6
ISO
ClinVar Annotator: match by term: Hypotension
ClinVar
PMID:28492532
NCBI chr17:67,887,939...67,945,052
Ensembl chr17:67,887,939...67,945,037
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Kng2
kininogen 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:1334354 PMID:2404862 PMID:6675575 PMID:9249246 PMID:10805402 PMID:14744816 PMID:16321614 PMID:18084312 PMID:21420289
NCBI chr11:81,509,185...81,516,759
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Ltf
lactotransferrin
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:14563657
NCBI chr 8:119,290,416...119,313,261
Ensembl chr 8:119,290,416...119,313,261
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Maoa
monoamine oxidase A
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:11834493
NCBI chr X:6,554,698...6,620,722
Ensembl chr X:6,554,698...6,620,722
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Maob
monoamine oxidase B
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:11834493
NCBI chr X:6,430,694...6,533,520
Ensembl chr X:6,430,594...6,533,534
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Nisch
nischarin
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:11486246 PMID:22613216
NCBI chr16:7,254,372...7,290,670
Ensembl chr16:7,254,974...7,290,561
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Nppa
natriuretic peptide A
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:2951327 PMID:2961279
NCBI chr 5:164,808,407...164,809,716
Ensembl chr 5:164,808,323...164,809,705
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Nppb
natriuretic peptide B
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:9194512 PMID:20339970
NCBI chr 5:164,796,176...164,797,538
Ensembl chr 5:164,796,185...164,797,531
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Oxt
oxytocin/neurophysin I prepropeptide
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:11171655
NCBI chr 3:123,106,694...123,107,534
Ensembl chr 3:123,106,694...123,107,534
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Pdyn
prodynorphin
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:1676337 PMID:2536002 PMID:2566129 PMID:6131355
NCBI chr 3:122,194,327...122,206,671
Ensembl chr 3:122,194,329...122,206,671
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Plat
plasminogen activator, tissue type
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:1492007
NCBI chr16:74,098,263...74,122,897
Ensembl chr16:74,098,260...74,122,889
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Plau
plasminogen activator, urokinase
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:10392865
NCBI chr15:3,644,296...3,650,765
Ensembl chr15:3,644,769...3,650,819
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Plcd1
phospholipase C, delta 1
susceptibility
IAGP
DNA:missense mutation
RGD
PMID:1358065
RGD:2300422
NCBI chr 8:127,753,514...127,782,070
Ensembl chr 8:127,753,539...127,782,070
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Pnoc
prepronociceptin
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:10794074
NCBI chr15:48,805,841...48,833,071
Ensembl chr15:48,805,228...48,833,285
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Pomc
proopiomelanocortin
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:1676337 PMID:2536002 PMID:2566129 PMID:2636709
NCBI chr 6:28,382,937...28,388,771
Ensembl chr 6:28,382,962...28,388,967
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Por
cytochrome p450 oxidoreductase
IEP
mRNA:increased expression:kidney (rat)
RGD
PMID:15942020
RGD:1625563
NCBI chr12:23,998,411...24,017,063
Ensembl chr12:23,998,411...24,046,814
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Prl
prolactin
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:71628 PMID:6350720
NCBI chr17:39,814,236...39,824,299
Ensembl chr17:39,814,244...39,824,299
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Ptafr
platelet-activating factor receptor
treatment
IMP
RGD
PMID:3011900
RGD:10043179
NCBI chr 5:150,746,284...150,775,675
Ensembl chr 5:150,754,021...150,775,672
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Ptger4
prostaglandin E receptor 4
IDA
RGD
PMID:15201706
RGD:1581283
NCBI chr 2:54,951,625...54,966,470
Ensembl chr 2:54,952,821...54,963,448
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Ren
renin
ISO
CTD Direct Evidence: marker/mechanism|therapeutic
CTD
PMID:3536153 PMID:6251761 PMID:11171655
NCBI chr13:50,502,724...50,513,953
Ensembl chr13:50,502,724...50,514,151
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S100b
S100 calcium binding protein B
IEP
protein:increased expression:serum
RGD
PMID:17944636
RGD:5508837
NCBI chr20:13,130,633...13,142,856
Ensembl chr20:13,130,636...13,142,856
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Scnn1g
sodium channel epithelial 1 subunit gamma
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:11463765
NCBI chr 1:191,704,397...191,738,271
Ensembl chr 1:191,704,311...191,738,268
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Slc9a3
solute carrier family 9 member A3
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:26564064
NCBI chr 1:31,731,652...31,777,144
Ensembl chr 1:31,734,327...31,777,070
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Sod1
superoxide dismutase 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:9024144
NCBI chr11:30,363,282...30,368,858
Ensembl chr11:30,363,280...30,368,862
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Sult1a1
sulfotransferase family 1A member 1
IEP
mRNA:increased expression:kidney
RGD
PMID:15942020
RGD:1625563
NCBI chr 1:198,100,586...198,104,106
Ensembl chr 1:198,100,586...198,104,109
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Tac1
tachykinin, precursor 1
IMP ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:2445440 PMID:20138590 , PMID:18337316
RGD:2304320
NCBI chr 4:33,638,853...33,646,819
Ensembl chr 4:33,638,709...33,646,819
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Tacr1
tachykinin receptor 1
IDA IMP
RGD
PMID:19261870 , PMID:18337316
RGD:2304250 , RGD:2304320
NCBI chr 4:113,247,236...113,416,139
Ensembl chr 4:113,247,795...113,414,504
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Tacr3
tachykinin receptor 3
IMP
RGD
PMID:18650316
RGD:2305929
NCBI chr 2:240,021,152...240,118,971
Ensembl chr 2:240,021,152...240,118,971
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test
test1
onset MODEL: induced
IDA TAS IAGP IMP IEP
fr str61106wastas fr str628908 iep fr bp338 iep fr Bp337 fr bp339 no qual fr Bp336 as compared to SHR/OlaIpcv - from shr-18 iep fr str 2306894 fr str 2306893 iep fr str 2306892 iep fr str 2306895
RGD
PMID:9453331 , PMID:9453331 , PMID:19126752 , PMID:19126752 , PMID:19126752 , PMID:19126752 , PMID:19620519 , PMID:19126752 , PMID:19126752 , PMID:19126752 , PMID:19126752
RGD:619652 , RGD:619652 , RGD:2306880 , RGD:2306880 , RGD:2306880 , RGD:2306880 , RGD:2312571 , RGD:2306880 , RGD:2306880 , RGD:2306880 , RGD:2306880
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Tnf
tumor necrosis factor
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:10379864 PMID:15384034
NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000 Ensembl chr20:5,189,390...5,192,000
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Ucn
urocortin
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:10213916
NCBI chr 6:26,602,144...26,602,974
Ensembl chr 6:26,602,144...26,602,974
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Vip
vasoactive intestinal peptide
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:9881641
NCBI chr 1:42,169,307...42,177,582
Ensembl chr 1:42,169,501...42,177,582
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Xdh
xanthine dehydrogenase
IEP
protein:alternative form:ileum
RGD
PMID:9895379
RGD:13209132
NCBI chr 6:25,149,570...25,211,273
Ensembl chr 6:25,149,235...25,211,494
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Dbh
dopamine beta-hydroxylase
ISO
ClinVar Annotator: match by term: Orthostatic hypotension 1 ClinVar Annotator: match by term: Dopamine beta hydroxylase deficiency ClinVar Annotator: match by OMIM:223360
OMIM ClinVar
PMID:11857564 PMID:14598346 PMID:15060114 PMID:21209083 PMID:21471955 PMID:22028891 PMID:24033266 PMID:25450229 PMID:25741868 PMID:26762739 PMID:27778639 PMID:28492532
NCBI chr 3:5,709,236...5,731,895
Ensembl chr 3:5,709,236...5,731,898
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Hspa5
heat shock protein family A (Hsp70) member 5
ISO
RGD
PMID:21209083
RGD:5685690
NCBI chr 3:13,838,304...13,842,763
Ensembl chr 3:13,838,304...13,842,762
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Abcb1a
ATP binding cassette subfamily B member 1A
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:12082591
NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515
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Gnas
GNAS complex locus
sussceptibility
ISO
DNA:SNP: : 393T>C(human)
RGD
PMID:11910300
RGD:1580406
NCBI chr 3:172,374,957...172,434,988
Ensembl chr 3:172,374,957...172,428,483 Ensembl chr 3:172,374,957...172,428,483
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Gnb3
G protein subunit beta 3
susceptibility
ISO
DNA:SNP: : 825C>T (human)
RGD
PMID:11910300
RGD:1580406
NCBI chr 4:157,352,558...157,359,237
Ensembl chr 4:157,352,372...157,358,262
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Mt-nd2
mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 2
ISO
RGD
PMID:10449650
RGD:1581056
NCBI chr MT:3,904...4,942
Ensembl chr MT:3,904...4,942
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Oprd1
opioid receptor, delta 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:2981652
NCBI chr 5:150,288,126...150,323,063
Ensembl chr 5:150,288,126...150,323,063
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Oprm1
opioid receptor, mu 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:2981652
NCBI chr 1:43,454,803...43,704,948
Ensembl chr 1:43,454,803...43,704,948
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Cyb561
cytochrome b-561
ISO
ClinVar Annotator: match by term: ORTHOSTATIC HYPOTENSION 2
ClinVar OMIM
NCBI chr10:94,136,993...94,147,567
Ensembl chr10:94,136,993...94,147,621
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Avp
arginine vasopressin
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:6850280
NCBI chr 3:123,117,482...123,119,460
Ensembl chr 3:123,117,492...123,119,460
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