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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:Hypotension
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Accession:DOID:9006024 term browser browse the term
Definition:Abnormally low BLOOD PRESSURE that can result in inadequate blood flow to the brain and other vital organs. Common symptom is DIZZINESS but greater negative impacts on the body occur when there is prolonged depravation of oxygen and nutrients.
Synonyms:exact_synonym: Low Blood Pressure;   Vascular Hypotension
 primary_id: MESH:D007022;   RDO:0005869
For additional species annotation, visit the Alliance of Genome Resources.

show annotations for term's descendants           Sort by:
 
Hypotension term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ace angiotensin I converting enzyme ISO CTD Direct Evidence: therapeutic CTD PMID:3544871 NCBI chr10:94,170,766...94,213,831
Ensembl chr10:94,170,766...94,187,822 		JBrowse link
G Adk adenosine kinase IMP RGD PMID:9435554 RGD:6482668 NCBI chr15:3,033,535...3,435,888
Ensembl chr15:3,033,495...3,435,888 		JBrowse link
G Adora1 adenosine A1 receptor ISO CTD Direct Evidence: marker/mechanism CTD PMID:15641640 PMID:18313046 NCBI chr13:51,042,111...51,076,913
Ensembl chr13:51,042,248...51,076,852 		JBrowse link
G Adora2a adenosine A2a receptor ISO CTD Direct Evidence: marker/mechanism CTD PMID:1592228 PMID:15641640 PMID:18313046 NCBI chr20:14,265,251...14,282,873
Ensembl chr20:14,265,252...14,282,873 		JBrowse link
G Adra1a adrenoceptor alpha 1A IDA RGD PMID:12433595 RGD:1625780 NCBI chr15:43,296,997...43,398,314
Ensembl chr15:43,298,794...43,392,451 		JBrowse link
G Adra1b adrenoceptor alpha 1B ISO CTD Direct Evidence: marker/mechanism CTD PMID:11278430 NCBI chr10:29,392,762...29,450,644
Ensembl chr10:29,392,762...29,450,644 		JBrowse link
G Adra2a adrenoceptor alpha 2A ISO CTD Direct Evidence: marker/mechanism CTD PMID:16595736 PMID:18849358 NCBI chr 1:274,766,283...274,769,083
Ensembl chr 1:274,766,283...274,769,081 		JBrowse link
G Agt angiotensinogen ISO CTD Direct Evidence: therapeutic CTD PMID:3078272 PMID:8527259 PMID:9323291, PMID:9466969 RGD:737778 NCBI chr19:57,321,594...57,333,460
Ensembl chr19:57,321,640...57,333,433 		JBrowse link
G Akr1c1 aldo-keto reductase family 1, member C1 ISO ClinVar Annotator: match by term: Hypotension ClinVar PMID:28492532 NCBI chr17:69,441,253...69,460,334
Ensembl chr17:69,441,223...69,460,321 		JBrowse link
G Alb albumin ISO CTD Direct Evidence: marker/mechanism CTD PMID:4463119 PMID:11229087 NCBI chr14:19,176,275...19,191,793
Ensembl chr14:19,176,277...19,191,863 		JBrowse link
G Avp arginine vasopressin ISO CTD Direct Evidence: therapeutic CTD PMID:2485266 PMID:3544871 PMID:11171655 PMID:12019395 PMID:17357383 NCBI chr 3:123,117,482...123,119,460
Ensembl chr 3:123,117,492...123,119,460 		JBrowse link
G Bdkrb2 bradykinin receptor B2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:1334354 PMID:16321614, PMID:9039147 RGD:4891024 NCBI chr 6:129,399,468...129,429,676
Ensembl chr 6:129,399,468...129,429,676 		JBrowse link
G Bnc2 basonuclin 2 ISO ClinVar Annotator: match by term: Hypotension ClinVar PMID:24033266 PMID:28492532 NCBI chr 5:102,407,508...102,807,389
Ensembl chr 5:102,415,847...102,786,331 		JBrowse link
G Cat catalase ISO CTD Direct Evidence: therapeutic CTD PMID:15612528 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058 		JBrowse link
G Cnr1 cannabinoid receptor 1 IMP
ISO		 CTD Direct Evidence: marker/mechanism CTD PMID:9888857, PMID:19295473 RGD:2314676 NCBI chr 5:49,307,584...49,333,064
Ensembl chr 5:49,311,030...49,333,056 		JBrowse link
G Crh corticotropin releasing hormone ISO CTD Direct Evidence: marker/mechanism CTD PMID:1320258 PMID:6093200 NCBI chr 2:104,459,999...104,461,863
Ensembl chr 2:104,459,999...104,461,863 		JBrowse link
G Crhr2 corticotropin releasing hormone receptor 2 IDA RGD PMID:11036160 RGD:1581302 NCBI chr 4:85,286,371...85,329,374
Ensembl chr 4:85,286,372...85,329,362 		JBrowse link
G Ctf1 cardiotrophin 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:11304496 NCBI chr 1:199,162,319...199,168,296
Ensembl chr 1:199,163,086...199,168,296 		JBrowse link
G Dbh dopamine beta-hydroxylase ISO RGD PMID:12969876 RGD:5129693 NCBI chr 3:5,709,236...5,731,895
Ensembl chr 3:5,709,236...5,731,898 		JBrowse link
G Drd1 dopamine receptor D1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:1724532 PMID:12946566 NCBI chr17:11,099,736...11,104,352
Ensembl chr17:11,101,306...11,103,541 		JBrowse link
G Drd2 dopamine receptor D2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:1724532 PMID:9917201 PMID:10626749 PMID:12946566 NCBI chr 8:53,678,777...53,743,643
Ensembl chr 8:53,678,777...53,743,642 		JBrowse link
G Edn1 endothelin 1 ISO CTD Direct Evidence: therapeutic CTD PMID:1309933 PMID:10399635, PMID:20516397 RGD:4144881 NCBI chr17:22,136,814...22,143,745
Ensembl chr17:22,137,324...22,143,324 		JBrowse link
G Edn2 endothelin 2 ISO CTD Direct Evidence: therapeutic CTD PMID:1309933 NCBI chr 5:139,098,472...139,106,396
Ensembl chr 5:139,100,898...139,105,792 		JBrowse link
G Edn3 endothelin 3 ISO CTD Direct Evidence: marker/mechanism|therapeutic CTD PMID:1309933 PMID:7982458 NCBI chr 3:172,856,730...172,879,276
Ensembl chr 3:172,856,733...172,880,450 		JBrowse link
G Fgf1 fibroblast growth factor 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:9233905 NCBI chr18:32,273,830...32,359,831
Ensembl chr18:32,273,770...32,359,824 		JBrowse link
G Gcg glucagon ISO CTD Direct Evidence: therapeutic CTD PMID:3277781 PMID:8517581 NCBI chr 3:48,442,635...48,451,650
Ensembl chr 3:48,442,635...48,451,650 		JBrowse link
G Gria1 glutamate ionotropic receptor AMPA type subunit 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18639534 NCBI chr10:42,441,723...42,760,200
Ensembl chr10:42,614,713...42,760,200 		JBrowse link
G Grin2b glutamate ionotropic receptor NMDA type subunit 2B ISO CTD Direct Evidence: marker/mechanism CTD PMID:18639534 NCBI chr 4:169,541,620...170,000,216
Ensembl chr 4:169,560,387...169,999,873 		JBrowse link
G Gstm1 glutathione S-transferase mu 1 IEP mRNA:increased expression:kidney (rat) RGD PMID:15942020 RGD:1625563 NCBI chr 2:210,803,869...210,809,461
Ensembl chr 2:210,803,869...210,809,306 		JBrowse link
G Hrh1 histamine receptor H 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:2105067 NCBI chr 4:146,374,596...146,458,148
Ensembl chr 4:146,455,332...146,457,074 		JBrowse link
G Htr1b 5-hydroxytryptamine receptor 1B ISO CTD Direct Evidence: marker/mechanism CTD PMID:9109356 NCBI chr 8:89,113,984...89,130,830
Ensembl chr 8:89,129,453...89,130,991 		JBrowse link
G Htr1d 5-hydroxytryptamine receptor 1D ISO CTD Direct Evidence: marker/mechanism CTD PMID:9109356 NCBI chr 5:154,780,958...154,801,505
Ensembl chr 5:154,800,226...154,801,350 		JBrowse link
G Ifng interferon gamma ISO CTD Direct Evidence: marker/mechanism CTD PMID:3091246 NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419 		JBrowse link
G Il1a interleukin 1 alpha ISO CTD Direct Evidence: marker/mechanism CTD PMID:15384034 NCBI chr 3:121,824,712...121,836,122
Ensembl chr 3:121,825,412...121,836,086 		JBrowse link
G Il1b interleukin 1 beta ISO CTD Direct Evidence: marker/mechanism CTD PMID:1884014 PMID:15384034 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726 		JBrowse link
G Il2 interleukin 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:8635092 NCBI chr 2:123,847,150...123,851,854
Ensembl chr 2:123,847,150...123,851,854 		JBrowse link
G Il6 interleukin 6 ISO CTD Direct Evidence: marker/mechanism CTD PMID:15217654 PMID:15384034 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807 		JBrowse link
G Ins2 insulin 2 ISO CTD Direct Evidence: marker/mechanism|therapeutic CTD PMID:48835 PMID:1324617 PMID:7418494 NCBI chr 1:215,856,967...215,858,034
Ensembl chr 1:215,856,971...215,858,034 		JBrowse link
G Klf6 Kruppel-like factor 6 ISO ClinVar Annotator: match by term: Hypotension ClinVar PMID:28492532 NCBI chr17:67,887,939...67,945,052
Ensembl chr17:67,887,939...67,945,037 		JBrowse link
G Kng2 kininogen 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:1334354 PMID:2404862 PMID:6675575 PMID:9249246 PMID:10805402 PMID:14744816 PMID:16321614 PMID:18084312 PMID:21420289 NCBI chr11:81,509,185...81,516,759 JBrowse link
G Ltf lactotransferrin ISO CTD Direct Evidence: marker/mechanism CTD PMID:14563657 NCBI chr 8:119,290,416...119,313,261
Ensembl chr 8:119,290,416...119,313,261 		JBrowse link
G Maoa monoamine oxidase A ISO CTD Direct Evidence: marker/mechanism CTD PMID:11834493 NCBI chr  X:6,554,698...6,620,722
Ensembl chr  X:6,554,698...6,620,722 		JBrowse link
G Maob monoamine oxidase B ISO CTD Direct Evidence: marker/mechanism CTD PMID:11834493 NCBI chr  X:6,430,694...6,533,520
Ensembl chr  X:6,430,594...6,533,534 		JBrowse link
G Nisch nischarin ISO CTD Direct Evidence: marker/mechanism CTD PMID:11486246 PMID:22613216 NCBI chr16:7,254,372...7,290,670
Ensembl chr16:7,254,974...7,290,561 		JBrowse link
G Nppa natriuretic peptide A ISO CTD Direct Evidence: marker/mechanism CTD PMID:2951327 PMID:2961279 NCBI chr 5:164,808,407...164,809,716
Ensembl chr 5:164,808,323...164,809,705 		JBrowse link
G Nppb natriuretic peptide B ISO CTD Direct Evidence: marker/mechanism CTD PMID:9194512 PMID:20339970 NCBI chr 5:164,796,176...164,797,538
Ensembl chr 5:164,796,185...164,797,531 		JBrowse link
G Oxt oxytocin/neurophysin I prepropeptide ISO CTD Direct Evidence: marker/mechanism CTD PMID:11171655 NCBI chr 3:123,106,694...123,107,534
Ensembl chr 3:123,106,694...123,107,534 		JBrowse link
G Pdyn prodynorphin ISO CTD Direct Evidence: marker/mechanism CTD PMID:1676337 PMID:2536002 PMID:2566129 PMID:6131355 NCBI chr 3:122,194,327...122,206,671
Ensembl chr 3:122,194,329...122,206,671 		JBrowse link
G Plat plasminogen activator, tissue type ISO CTD Direct Evidence: marker/mechanism CTD PMID:1492007 NCBI chr16:74,098,263...74,122,897
Ensembl chr16:74,098,260...74,122,889 		JBrowse link
G Plau plasminogen activator, urokinase ISO CTD Direct Evidence: marker/mechanism CTD PMID:10392865 NCBI chr15:3,644,296...3,650,765
Ensembl chr15:3,644,769...3,650,819 		JBrowse link
G Plcd1 phospholipase C, delta 1 susceptibility IAGP DNA:missense mutation RGD PMID:1358065 RGD:2300422 NCBI chr 8:127,753,514...127,782,070
Ensembl chr 8:127,753,539...127,782,070 		JBrowse link
G Pnoc prepronociceptin ISO CTD Direct Evidence: marker/mechanism CTD PMID:10794074 NCBI chr15:48,805,841...48,833,071
Ensembl chr15:48,805,228...48,833,285 		JBrowse link
G Pomc proopiomelanocortin ISO CTD Direct Evidence: marker/mechanism CTD PMID:1676337 PMID:2536002 PMID:2566129 PMID:2636709 NCBI chr 6:28,382,937...28,388,771
Ensembl chr 6:28,382,962...28,388,967 		JBrowse link
G Por cytochrome p450 oxidoreductase IEP mRNA:increased expression:kidney (rat) RGD PMID:15942020 RGD:1625563 NCBI chr12:23,998,411...24,017,063
Ensembl chr12:23,998,411...24,046,814 		JBrowse link
G Prl prolactin ISO CTD Direct Evidence: marker/mechanism CTD PMID:71628 PMID:6350720 NCBI chr17:39,814,236...39,824,299
Ensembl chr17:39,814,244...39,824,299 		JBrowse link
G Ptafr platelet-activating factor receptor treatment IMP RGD PMID:3011900 RGD:10043179 NCBI chr 5:150,746,284...150,775,675
Ensembl chr 5:150,754,021...150,775,672 		JBrowse link
G Ptger4 prostaglandin E receptor 4 IDA RGD PMID:15201706 RGD:1581283 NCBI chr 2:54,951,625...54,966,470
Ensembl chr 2:54,952,821...54,963,448 		JBrowse link
G Ren renin ISO CTD Direct Evidence: marker/mechanism|therapeutic CTD PMID:3536153 PMID:6251761 PMID:11171655 NCBI chr13:50,502,724...50,513,953
Ensembl chr13:50,502,724...50,514,151 		JBrowse link
G S100b S100 calcium binding protein B IEP protein:increased expression:serum RGD PMID:17944636 RGD:5508837 NCBI chr20:13,130,633...13,142,856
Ensembl chr20:13,130,636...13,142,856 		JBrowse link
G Scnn1g sodium channel epithelial 1 subunit gamma ISO CTD Direct Evidence: marker/mechanism CTD PMID:11463765 NCBI chr 1:191,704,397...191,738,271
Ensembl chr 1:191,704,311...191,738,268 		JBrowse link
G Slc9a3 solute carrier family 9 member A3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:26564064 NCBI chr 1:31,731,652...31,777,144
Ensembl chr 1:31,734,327...31,777,070 		JBrowse link
G Sod1 superoxide dismutase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:9024144 NCBI chr11:30,363,282...30,368,858
Ensembl chr11:30,363,280...30,368,862 		JBrowse link
G Sult1a1 sulfotransferase family 1A member 1 IEP mRNA:increased expression:kidney RGD PMID:15942020 RGD:1625563 NCBI chr 1:198,100,586...198,104,106
Ensembl chr 1:198,100,586...198,104,109 		JBrowse link
G Tac1 tachykinin, precursor 1 IMP
ISO		 CTD Direct Evidence: marker/mechanism CTD PMID:2445440 PMID:20138590, PMID:18337316 RGD:2304320 NCBI chr 4:33,638,853...33,646,819
Ensembl chr 4:33,638,709...33,646,819 		JBrowse link
G Tacr1 tachykinin receptor 1 IDA
IMP		 RGD PMID:19261870, PMID:18337316 RGD:2304250, RGD:2304320 NCBI chr 4:113,247,236...113,416,139
Ensembl chr 4:113,247,795...113,414,504 		JBrowse link
G Tacr3 tachykinin receptor 3 IMP RGD PMID:18650316 RGD:2305929 NCBI chr 2:240,021,152...240,118,971
Ensembl chr 2:240,021,152...240,118,971 		JBrowse link
G test test1 onset
MODEL: induced		 IDA
TAS
IAGP
IMP
IEP		 fr str61106wastas
fr str628908
iep fr bp338
iep fr Bp337
fr bp339 no qual
fr Bp336
as compared to SHR/OlaIpcv - from shr-18
iep fr str 2306894
fr str 2306893
iep fr str 2306892
iep fr str 2306895		 RGD PMID:9453331, PMID:9453331, PMID:19126752, PMID:19126752, PMID:19126752, PMID:19126752, PMID:19620519, PMID:19126752, PMID:19126752, PMID:19126752, PMID:19126752 RGD:619652, RGD:619652, RGD:2306880, RGD:2306880, RGD:2306880, RGD:2306880, RGD:2312571, RGD:2306880, RGD:2306880, RGD:2306880, RGD:2306880
G Tnf tumor necrosis factor ISO CTD Direct Evidence: marker/mechanism CTD PMID:10379864 PMID:15384034 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
Ensembl chr20:5,189,390...5,192,000 		JBrowse link
G Ucn urocortin ISO CTD Direct Evidence: marker/mechanism CTD PMID:10213916 NCBI chr 6:26,602,144...26,602,974
Ensembl chr 6:26,602,144...26,602,974 		JBrowse link
G Vip vasoactive intestinal peptide ISO CTD Direct Evidence: marker/mechanism CTD PMID:9881641 NCBI chr 1:42,169,307...42,177,582
Ensembl chr 1:42,169,501...42,177,582 		JBrowse link
G Xdh xanthine dehydrogenase IEP protein:alternative form:ileum RGD PMID:9895379 RGD:13209132 NCBI chr 6:25,149,570...25,211,273
Ensembl chr 6:25,149,235...25,211,494 		JBrowse link
dopamine beta-hydroxylase deficiency term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dbh dopamine beta-hydroxylase ISO ClinVar Annotator: match by term: Orthostatic hypotension 1
ClinVar Annotator: match by term: Dopamine beta hydroxylase deficiency
ClinVar Annotator: match by OMIM:223360		 OMIM
ClinVar		 PMID:11857564 PMID:14598346 PMID:15060114 PMID:21209083 PMID:21471955 PMID:22028891 PMID:24033266 PMID:25450229 PMID:25741868 PMID:26762739 PMID:27778639 PMID:28492532 NCBI chr 3:5,709,236...5,731,895
Ensembl chr 3:5,709,236...5,731,898 		JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 ISO RGD PMID:21209083 RGD:5685690 NCBI chr 3:13,838,304...13,842,763
Ensembl chr 3:13,838,304...13,842,762 		JBrowse link
Orthostatic Hypotension term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A ISO CTD Direct Evidence: marker/mechanism CTD PMID:12082591 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515 		JBrowse link
G Gnas GNAS complex locus sussceptibility ISO DNA:SNP: : 393T>C(human) RGD PMID:11910300 RGD:1580406 NCBI chr 3:172,374,957...172,434,988
Ensembl chr 3:172,374,957...172,428,483
Ensembl chr 3:172,374,957...172,428,483 		JBrowse link
G Gnb3 G protein subunit beta 3 susceptibility ISO DNA:SNP: : 825C>T (human) RGD PMID:11910300 RGD:1580406 NCBI chr 4:157,352,558...157,359,237
Ensembl chr 4:157,352,372...157,358,262 		JBrowse link
G Mt-nd2 mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 2 ISO RGD PMID:10449650 RGD:1581056 NCBI chr MT:3,904...4,942
Ensembl chr MT:3,904...4,942 		JBrowse link
G Oprd1 opioid receptor, delta 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:2981652 NCBI chr 5:150,288,126...150,323,063
Ensembl chr 5:150,288,126...150,323,063 		JBrowse link
G Oprm1 opioid receptor, mu 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:2981652 NCBI chr 1:43,454,803...43,704,948
Ensembl chr 1:43,454,803...43,704,948 		JBrowse link
Orthostatic Hypotension 2 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyb561 cytochrome b-561 ISO ClinVar Annotator: match by term: ORTHOSTATIC HYPOTENSION 2 ClinVar
OMIM		 NCBI chr10:94,136,993...94,147,567
Ensembl chr10:94,136,993...94,147,621 		JBrowse link
Shy-Drager Syndrome term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Avp arginine vasopressin ISO CTD Direct Evidence: marker/mechanism CTD PMID:6850280 NCBI chr 3:123,117,482...123,119,460
Ensembl chr 3:123,117,492...123,119,460 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 16909
    disease of anatomical entity 16281
      cardiovascular system disease 4395
        vascular disease 3322
          Hypotension 147
            Orthostatic Hypotension + 9
            Post-Exercise Hypotension 0
            Shy-Drager Syndrome 1
paths to the root