RGD Reference Report - Antalarmin blockade of corticotropin releasing hormone-induced hypertension in rats. - Rat Genome Database

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Antalarmin blockade of corticotropin releasing hormone-induced hypertension in rats.

Authors: Briscoe, RJ  Cabrera, CL  Baird, TJ  Rice, KC  Woods, JH 
Citation: Briscoe RJ, etal., Brain Res. 2000 Oct 27;881(2):204-7.
RGD ID: 1581302
Pubmed: PMID:11036160   (View Abstract at PubMed)

Central administration of CRH results in endocrinological, cardiovascular, and behavioral effects that suggest stress or anxiety. Among these is a marked pressor response. Parenteral administration of CRH, however, results in hypotension. We used parenteral administration of antalarmin, a novel, small molecule CRH1 receptor antagonist, and alpha-helical CRH(9-41), a peptidic CRHR1/CRHR2 antagonist to attempt to determine the receptor mechanisms through which CRH is acting in both of these situations. Our results suggest that the hypertension produced by central CRH administration is mediated through central CRHR1 receptors, whereas the hypotension produced by parenteral CRH administration is mediated through peripheral CRHR2 receptors.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
CRHR1Humanhypertension  ISOCrhr1 (Rattus norvegicus)corticotropin releasing hormone-inducedRGD 
Crhr1Rathypertension  IDA corticotropin releasing hormone-inducedRGD 
Crhr1Mousehypertension  ISOCrhr1 (Rattus norvegicus)corticotropin releasing hormone-inducedRGD 
CRHR2HumanHypotension  ISOCrhr2 (Rattus norvegicus) RGD 
Crhr2RatHypotension  IDA  RGD 
Crhr2MouseHypotension  ISOCrhr2 (Rattus norvegicus) RGD 

Objects Annotated

Genes (Rattus norvegicus)
Crhr1  (corticotropin releasing hormone receptor 1)
Crhr2  (corticotropin releasing hormone receptor 2)

Genes (Mus musculus)
Crhr1  (corticotropin releasing hormone receptor 1)
Crhr2  (corticotropin releasing hormone receptor 2)

Genes (Homo sapiens)
CRHR1  (corticotropin releasing hormone receptor 1)
CRHR2  (corticotropin releasing hormone receptor 2)


Additional Information