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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml).
Term:methionine cycle/metabolic pathway
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Accession:PW:0000048 term browser browse the term
Definition:Those metabolic reactions involved in the synthesis (remethylation), utilization and/or degradation of methionine, an essential amino acid for humans. The cycle produces S-adenosylmethionine (AdoMet), the major methyl donor for proteins, nucleic acids, lipids and other small molecules. The cycle also produces homocysteine (Hcy) which either regenerates methionine via the remethylation pathway or leads to the synthesis of cysteine and derivatives via the transsulfuration pathway. Homocysteine and folate metabolic pathways are intimately related to the methionine cycle.
Synonyms:related_synonym: SMP:00033
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show annotations for term's descendants           Sort by:
methionine cycle/metabolic pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahcy adenosylhomocysteinase TAS
ISO
IMP		 SMPDB
RGD		 PMID:11741948 PMID:23073625 PMID:2292587 SMP:00033, RGD:730275, RGD:7242425, RGD:7242932 NCBI chr 3:143,569,134...143,584,359
Ensembl chr 3:143,569,094...143,584,393 		JBrowse link
G Amd1 adenosylmethionine decarboxylase 1 ISO
IMP		 SMPDB
RGD		 PMID:23073625 PMID:2292587 SMP:00033, RGD:7242425, RGD:7242932 NCBI chr20:43,695,783...43,711,476
Ensembl chr20:43,697,237...43,711,476 		JBrowse link
G As3mt arsenite methyltransferase TAS RGD PMID:11790780 RGD:625365 NCBI chr 1:245,595,939...245,628,921
Ensembl chr 1:245,596,108...245,627,872 		JBrowse link
G Asmt acetylserotonin O-methyltransferase IDA RGD PMID:12198599 RGD:1359073 NCBI chr12:16,304,719...16,309,568
Ensembl chr12:16,304,719...16,309,568 		JBrowse link
G Bhmt betaine-homocysteine S-methyltransferase IDA
ISO		 SMPDB
RGD		 PMID:15845641 PMID:23073625 SMP:00033, RGD:1359026, RGD:7242425 NCBI chr 2:24,859,871...24,879,449
Ensembl chr 2:24,859,873...24,879,742 		JBrowse link
G Carm1 coactivator-associated arginine methyltransferase 1 ISO RGD PMID:15866169 PMID:21074527 RGD:1359044, RGD:7242552 NCBI chr 8:20,097,262...20,141,950
Ensembl chr 8:20,097,254...20,147,689 		JBrowse link
G Cbs cystathionine beta synthase ISO SMPDB SMP:00033 NCBI chr20:9,708,089...9,732,623
Ensembl chr20:9,708,090...9,732,764 		JBrowse link
G Chdh choline dehydrogenase ISO SMPDB SMP:00033 NCBI chr16:5,194,269...5,225,541
Ensembl chr16:5,194,269...5,225,537 		JBrowse link
G Comt catechol-O-methyltransferase TAS RGD PMID:12584150 RGD:1359089 NCBI chr11:82,568,052...82,587,642
Ensembl chr11:82,568,025...82,587,642 		JBrowse link
G Cth cystathionine gamma-lyase ISO SMPDB SMP:00033 NCBI chr 2:246,975,888...247,002,234
Ensembl chr 2:246,975,894...247,002,234 		JBrowse link
G Dnmt1 DNA methyltransferase 1 TAS
ISO		 SMPDB
RGD		 PMID:12473678 PMID:22342103 SMP:00033, RGD:1359078, RGD:7242551 NCBI chr 8:19,440,611...19,486,659
Ensembl chr 8:19,440,611...19,486,659 		JBrowse link
G Dnmt3a DNA methyltransferase 3 alpha ISO RGD PMID:22342103 RGD:7242551 NCBI chr 6:26,791,517...26,902,161
Ensembl chr 6:26,822,609...26,896,687 		JBrowse link
G Dnmt3b DNA methyltransferase 3 beta ISO RGD PMID:22342103 RGD:7242551 NCBI chr 3:142,130,588...142,169,128
Ensembl chr 3:142,130,592...142,169,124 		JBrowse link
G Dot1l DOT1 like histone lysine methyltransferase ISO RGD PMID:12628190 PMID:22194015 RGD:1359080, RGD:7242554 NCBI chr 7:8,918,764...8,959,474
Ensembl chr 7:8,917,786...8,956,475 		JBrowse link
G Ezh2 enhancer of zeste 2 polycomb repressive complex 2 subunit ISO RGD PMID:22194015 RGD:7242554 NCBI chr 4:76,624,399...76,687,362
Ensembl chr 4:76,624,399...76,687,362 		JBrowse link
G Gamt guanidinoacetate N-methyltransferase IDA RGD PMID:15533043 RGD:1359081 NCBI chr 7:9,448,590...9,451,413
Ensembl chr 7:9,448,628...9,451,778 		JBrowse link
G Gnmt glycine N-methyltransferase IDA
ISO		 RGD PMID:15347642 PMID:23073625 PMID:22342103 RGD:1359070, RGD:7242425, RGD:7242551 NCBI chr 9:14,254,675...14,258,028
Ensembl chr 9:14,254,675...14,258,434 		JBrowse link
G Hnmt histamine N-methyltransferase ISS RGD PMID:11566133 RGD:1359041 NCBI chr 3:6,591,804...6,623,821
Ensembl chr 3:6,591,463...6,624,012 		JBrowse link
G Icmt isoprenylcysteine carboxyl methyltransferase ISS RGD PMID:15625008 RGD:1359083 NCBI chr 5:162,804,368...162,811,129
Ensembl chr 5:162,804,368...162,811,128 		JBrowse link
G Il4i1 interleukin 4 induced 1 ISO SMPDB SMP:00033 NCBI chr 1:95,299,457...95,324,564
Ensembl chr 1:95,295,601...95,324,562 		JBrowse link
G Kmt5a lysine methyltransferase 5A ISO RGD PMID:22194015 RGD:7242554 NCBI chr12:32,139,353...32,167,777
Ensembl chr12:32,139,178...32,162,711 		JBrowse link
G Mars1 methionyl-tRNA synthetase 1 ISO SMPDB SMP:00033 NCBI chr 7:63,121,142...63,138,550
Ensembl chr 7:63,121,142...63,138,495 		JBrowse link
G Mat1a methionine adenosyltransferase 1A IDA
ISO
IMP		 RGD PMID:9202427 PMID:23073625 PMID:2292587 RGD:1359039, RGD:7242425, RGD:7242932 NCBI chr16:16,983,084...17,001,284
Ensembl chr16:16,983,022...17,001,274 		JBrowse link
G Mat2a methionine adenosyltransferase 2A TAS
ISO		 SMPDB
RGD		 PMID:11099469 PMID:23073625 SMP:00033, RGD:1359040, RGD:7242425 NCBI chr 4:104,489,877...104,495,447
Ensembl chr 4:104,488,466...104,495,493 		JBrowse link
G Mat2b methionine adenosyltransferase 2 non-catalytic beta subunit ISO SMPDB
RGD		 PMID:23073625 SMP:00033, RGD:7242425 NCBI chr10:25,106,928...25,122,982
Ensembl chr10:25,106,930...25,122,777 		JBrowse link
G Mrm2 mitochondrial rRNA methyltransferase 2 ISO RGD PMID:11827451 RGD:1359074 NCBI chr12:14,309,556...14,314,759
Ensembl chr12:14,251,941...14,314,118 		JBrowse link
G Msrb2 methionine sulfoxide reductase B2 ISO SMPDB SMP:00033 NCBI chr17:81,974,378...82,000,044
Ensembl chr17:81,974,196...82,000,043 		JBrowse link
G Msrb3 methionine sulfoxide reductase B3 ISO SMPDB SMP:00033 NCBI chr 7:56,260,985...56,426,004
Ensembl chr 7:56,303,308...56,425,496 		JBrowse link
G Mtap methylthioadenosine phosphorylase ISO
IMP		 SMPDB
RGD		 PMID:23073625 PMID:2292587 SMP:00033, RGD:7242425, RGD:7242932 NCBI chr 5:103,874,460...103,920,684
Ensembl chr 5:103,873,020...103,939,406 		JBrowse link
G Mtfmt mitochondrial methionyl-tRNA formyltransferase ISO SMPDB SMP:00033 NCBI chr 8:65,953,787...65,971,841
Ensembl chr 8:65,953,767...65,971,841 		JBrowse link
G Mthfr methylenetetrahydrofolate reductase ISO SMPDB
RGD		 PMID:11933257 SMP:00033, RGD:1535021 NCBI chr 5:158,465,248...158,484,999
Ensembl chr 5:158,465,296...158,483,797 		JBrowse link
G Mtr 5-methyltetrahydrofolate-homocysteine methyltransferase IDA
ISO		 SMPDB
RGD		 PMID:15845641 PMID:23073625 PMID:20814827 SMP:00033, RGD:1359026, RGD:7242425, RGD:7242426 NCBI chr17:58,219,998...58,308,560
Ensembl chr17:58,220,071...58,304,822 		JBrowse link
G Mtrr 5-methyltetrahydrofolate-homocysteine methyltransferase reductase ISO RGD PMID:15979034 PMID:20814827 RGD:1359037, RGD:7242426 NCBI chr 1:34,866,991...34,899,425
Ensembl chr 1:34,867,089...34,899,425 		JBrowse link
G Nnmt nicotinamide N-methyltransferase ISO RGD PMID:15922112 RGD:1359084 NCBI chr 8:48,928,663...48,947,734
Ensembl chr 8:48,933,598...48,946,655 		JBrowse link
G Pcmt1 protein-L-isoaspartate (D-aspartate) O-methyltransferase 1 IDA RGD PMID:8263531 RGD:729481 NCBI chr 1:2,111,756...2,160,354
Ensembl chr 1:2,111,763...2,159,201 		JBrowse link
G Pemt phosphatidylethanolamine N-methyltransferase IDA RGD PMID:8344945 RGD:729486 NCBI chr10:44,775,910...44,849,990
Ensembl chr10:44,775,911...44,850,013 		JBrowse link
G Pnmt phenylethanolamine-N-methyltransferase TAS RGD PMID:12438084 RGD:1359087 NCBI chr10:83,383,019...83,386,557
Ensembl chr10:83,384,923...83,386,556 		JBrowse link
G Prmt1 protein arginine methyltransferase 1 ISS
ISO		 RGD PMID:15866169 PMID:21074527 RGD:1359044, RGD:7242552 NCBI chr 1:95,458,853...95,468,176
Ensembl chr 1:95,458,850...95,468,345 		JBrowse link
G Prmt2 protein arginine methyltransferase 2 ISO RGD PMID:21074527 RGD:7242552 NCBI chr20:12,394,748...12,420,643
Ensembl chr20:12,394,798...12,420,643 		JBrowse link
G Prmt3 protein arginine methyltransferase 3 ISS
ISO		 RGD PMID:15866169 PMID:21074527 RGD:1359044, RGD:7242552 NCBI chr 1:99,492,712...99,581,774
Ensembl chr 1:99,492,724...99,579,435 		JBrowse link
G Prmt5 protein arginine methyltransferase 5 ISO RGD PMID:15866169 PMID:21074527 RGD:1359044, RGD:7242552 NCBI chr15:27,968,893...27,978,291
Ensembl chr15:27,968,910...27,978,296 		JBrowse link
G Prmt6 protein arginine methyltransferase 6 ISO RGD PMID:15866169 PMID:21074527 RGD:1359044, RGD:7242552 NCBI chr 2:197,927,750...197,932,760
Ensembl chr 2:197,927,220...197,933,648 		JBrowse link
G Prmt7 protein arginine methyltransferase 7 ISO RGD PMID:21074527 RGD:7242552 NCBI chr19:34,110,724...34,161,531
Ensembl chr19:34,110,747...34,162,577 		JBrowse link
G Rnmt RNA (guanine-7-) methyltransferase ISO RGD PMID:11472630 RGD:1359071 NCBI chr18:61,886,230...61,909,775
Ensembl chr18:61,886,292...61,909,775 		JBrowse link
G Setd7 SET domain containing 7, histone lysine methyltransferase ISO RGD PMID:22194015 RGD:7242554 NCBI chr 2:135,562,683...135,605,468
Ensembl chr 2:135,562,683...135,605,468 		JBrowse link
G Setdb1 SET domain bifurcated histone lysine methyltransferase 1 ISO RGD PMID:11959841 RGD:1359072 NCBI chr 2:182,898,738...182,930,283
Ensembl chr 2:182,898,738...182,930,506 		JBrowse link
G Shmt1 serine hydroxymethyltransferase 1 ISO SMPDB SMP:00033 NCBI chr10:45,468,698...45,490,833
Ensembl chr10:45,468,700...45,497,820 		JBrowse link
G Sms spermine synthase ISO RGD PMID:23073625 RGD:7242425 NCBI chr  X:37,516,949...37,572,657
Ensembl chr  X:37,516,931...37,570,822 		JBrowse link
G Smyd2 SET and MYND domain containing 2 ISO RGD PMID:22194015 RGD:7242554 NCBI chr13:101,425,270...101,466,576
Ensembl chr13:101,425,273...101,466,576 		JBrowse link
G Srm spermidine synthase ISO SMPDB
RGD		 PMID:23073625 SMP:00033, RGD:7242425 NCBI chr 5:159,025,875...159,029,076
Ensembl chr 5:159,025,873...159,029,405 		JBrowse link
G Suv39h1 SUV39H1 histone lysine methyltransferase ISO RGD PMID:22194015 RGD:7242554 NCBI chr  X:14,421,028...14,433,993
Ensembl chr  X:14,421,109...14,433,982 		JBrowse link
G Suv39h1-ps1 SUV39H1 histone lysine methyltransferase, pseudogene 1 ISO RGD PMID:22194015 RGD:7242554 NCBI chr  X:141,792,589...141,795,257 JBrowse link
G Suv39h2 SUV39H2 histone lysine methyltransferase ISO RGD PMID:11094092 PMID:22194015 RGD:1359810, RGD:7242554 NCBI chr17:74,756,290...74,775,332
Ensembl chr17:74,756,306...74,775,332 		JBrowse link
G Trdmt1 tRNA aspartic acid methyltransferase 1 ISO RGD PMID:12794065 RGD:1359088 NCBI chr17:76,601,966...76,646,104
Ensembl chr17:76,610,543...76,645,439 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 6092
    classic metabolic pathway 1854
      amino acid metabolic pathway 308
        hydrophobic amino acid metabolic pathway 130
          methionine cycle/metabolic pathway 54
            altered methionine cycle/metabolic pathway 0
            methionine biosynthetic pathway 0
            methionine degradation pathway 0
Path 2
Term Annotations click to browse term
  pathway 6092
    regulatory pathway 3867
      homeostasis pathway 1773
        organic chemical homeostasis pathway 438
          S-adenosylmethionine homeostasis pathway 289
            methionine cycle/metabolic pathway 54
              altered methionine cycle/metabolic pathway 0
              methionine biosynthetic pathway 0
              methionine degradation pathway 0
paths to the root